                               SEQUENCE LISTING

<110> THE BROAD INSTITUTE, INC.
 
<120> IDENTIFICATION OF PDE3 MODULATOR RESPONSIVE CANCERS

<130> 167741.019402/PCT 

<140>
<141>

<150> 62/901,090
<151> 2019-09-16

<150> 62/754,290
<151> 2018-11-01

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 7319
<212> DNA
<213> Homo sapiens

<400> 1
gggggccact gggaattcag tgaagagggc accctatacc atggcagtgc ccggcgacgc       60

tgcacgagtc agggacaagc ccgtccacag tggggtgagt caagccccca cggcgggccg      120

ggactgccac catcgtgcgg accccgcatc gccgcgggac tcgggctgcc gtggctgctg      180

gggagacctg gtgctgcagc cgctccggag ctctcggaaa ctttcctccg cgctgtgcgc      240

gggctccctg tcctttctgc tggcgctgct ggtgaggctg gtccgcgggg aggtcggctg      300

tgacctggag cagtgtaagg aggcggcggc ggcggaggag gaggaagcag ccccgggagc      360

agaagggggc gtcttcccgg ggcctcgggg aggtgctccc gggggcggtg cgcggctcag      420

cccctggctg cagccctcgg cgctgctctt cagtctcctg tgtgccttct tctggatggg      480

cttgtacctc ctgcgcgccg gggtgcgcct gcctctggct gtcgcgctgc tggccgcctg      540

ctgcgggggg gaagcgctcg tccagattgg gctgggcgtc ggggaggatc acttactctc      600

actccccgcc gcgggggtgg tgctcagctg cttggccgcc gcgacatggc tggtgctgag      660

gctgaggctg ggcgtcctca tgatcgcctt gactagcgcg gtcaggaccg tgtccctcat      720

ttccttagag aggttcaagg tcgcctggag accttacctg gcgtacctgg ccggcgtgct      780

ggggatcctc ttggccaggt acgtggaaca aatcttgccg cagtccgcgg aggcggctcc      840

aagggagcat ttggggtccc agctgattgc tgggaccaag gaagatatcc cggtgtttaa      900

gaggaggagg cggtccagct ccgtcgtgtc cgccgagatg tccggctgca gcagcaagtc      960

ccatcggagg acctccctgc cctgtatacc gagggaacag ctcatggggc attcagaatg     1020

ggaccacaaa cgagggccaa gaggatcaca gtcttcagga accagtatta ctgtggacat     1080

cgccgtcatg ggcgaggccc acggcctcat taccgacctc ctggcagacc cttctcttcc     1140

accaaacgtg tgcacatcct tgagagccgt gagcaacttg ctcagcacac agctcacctt     1200

ccaggccatt cacaagccca gagtgaatcc cgtcacttcg ctcagtgaaa actatacctg     1260

ttctgactct gaagagagct ctgaaaaaga caagcttgct attccaaagc gcctgagaag     1320

gagtttgcct cctggcttgt tgagacgagt ttcttccact tggaccacca ccacctcggc     1380

cacaggtcta cccaccttgg agcctgcacc agtacggaga gaccgcagca ccagcatcaa     1440

actgcaggaa gcaccttcat ccagtcctga ttcttggaat aatccagtga tgatgaccct     1500

caccaaaagc agatccttta cttcatccta tgctatttct gcagctaacc atgtaaaggc     1560

taaaaagcaa agtcgaccag gtgccctcgc taaaatttca cctctttcat cgccctgctc     1620

ctcacctctc caagggactc ctgccagcag cctggtcagc aaaatttctg cagtgcagtt     1680

tccagaatct gctgacacaa ctgccaaaca aagcctaggt tctcacaggg ccttaactta     1740

cactcagagt gccccagacc tatcccctca aatcctgact ccacctgtta tatgtagcag     1800

ctgtggcaga ccatattccc aagggaatcc tgctgatgag cccctggaga gaagtggggt     1860

agccactcgg acaccaagta gaacagatga cactgctcaa gttacctctg attatgaaac     1920

caataacaac agtgacagca gtgacattgt acagaatgaa gatgaaacag agtgcctgag     1980

agagcctctg aggaaagcat cggcttgcag cacctatgct cctgagacca tgatgtttct     2040

ggacaaacca attcttgctc ccgaacctct tgtcatggat aacctggact caattatgga     2100

gcagctaaat acttggaatt ttccaatttt tgatttagtg gaaaatatag gaagaaaatg     2160

tggccgtatt cttagtcagg tatcttacag actttttgaa gacatgggcc tctttgaagc     2220

ttttaaaatt ccaattaggg aatttatgaa ttattttcat gctttggaga ttggatatag     2280

ggatattcct tatcataaca gaatccatgc cactgatgtt ttacatgctg tttggtatct     2340

tactacacag cctattccag gcctctcaac tgtgattaat gatcatggtt caaccagtga     2400

ttcagattct gacagtggat ttacacatgg acatatggga tatgtattct caaaaacgta     2460

taatgtgaca gatgataaat acggatgtct gtctgggaat atccctgcct tggagttgat     2520

ggcgctgtat gtggctgcag ccatgcacga ttatgatcat ccaggaagga ctaatgcttt     2580

cctggttgca actagtgctc ctcaggcggt gctatataac gatcgttcag ttttggagaa     2640

tcatcacgca gctgctgcat ggaatctttt catgtcccgg ccagagtata acttcttaat     2700

taaccttgac catgtggaat ttaagcattt ccgtttcctt gtcattgaag caattttggc     2760

cactgacctg aagaaacact ttgacttcgt agccaaattt aatggcaagg taaatgatga     2820

tgttggaata gattggacca atgaaaatga tcgtctactg gtttgtcaaa tgtgtataaa     2880

gttggctgat atcaatggtc cagctaaatg taaagaactc catcttcagt ggacagatgg     2940

tattgtcaat gaattttatg aacagggtga tgaagaggcc agccttggat tacccataag     3000

ccccttcatg gatcgttctg ctcctcagct ggccaacctt caggaatcct tcatctctca     3060

cattgtgggg cctctgtgca actcctatga ttcagcagga ctaatgcctg gaaaatgggt     3120

ggaagacagc gatgagtcag gagatactga tgacccagaa gaagaggagg aagaagcacc     3180

agcaccaaat gaagaggaaa cctgtgaaaa taatgaatct ccaaaaaaga agactttcaa     3240

aaggagaaaa atctactgcc aaataactca gcacctctta cagaaccaca agatgtggaa     3300

gaaagtcatt gaagaggagc aacggttggc aggcatagaa aatcaatccc tggaccagac     3360

ccctcagtcg cactcttcag aacagatcca ggctatcaag gaagaagaag aagagaaagg     3420

gaaaccaaga ggcgaggaga taccaaccca aaagccagac cagtgacaat ggatagaatg     3480

ggctgtgttt ccaaacagat tgacttgtca aagactctct tcaagccagc acaacattta     3540

gacacaacac tgtagaaatt tgagatgggc aaatggctat tgcattttgg gattcttcgc     3600

attttgtgtg tatattttta cagtgaggta cattgttaaa aactttttgc tcaaagaagc     3660

tttcacattg caacaccagc ttctaaggat tttttaagga gggaatatat atgtgtgtgt     3720

gtatataagc tcccacatag atacatgtaa aacatattca cacccatgca cgcacacaca     3780

tacacactga aggccacgat tgctggctcc acaatttagt aacatttata ttaagatata     3840

tatatagtgg tcactgtgat ataataaatc ataaaggaaa ccaaatcaca aaggagatgg     3900

tgtggcttag caaggaaaca gtgcaggaaa tgtaggttac caactaagca gcttttgctc     3960

ttagtactga gggatgaaag ttccagagca ttatttgaat tctgatacat cctgccaaca     4020

ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgaaaga gagacagaag     4080

ggaatggttt gagagggtgc ttgtgtgcat gtgtgtgcat atgtaaagag atttttgtgg     4140

tttaagtaac tcagaatagc tgtagcaaat gactgaatac atgtgaacaa acagaaggaa     4200

gttcactctg gagtgtcttt gggaggcagc cattccaaat gccctcctcc atttagcttc     4260

aataaagggc cttttgctga tggagggcac tcaagggctg ggtgagaggg ccacgtgttt     4320

ggtattacat tactgctatg caccacttga aggagctcta tcaccagcct caaacccgaa     4380

agactgaggc attttccagt ctacttgcct aatgaatgta taggaactgt ctatgagtat     4440

ggatgtcact caactaagat caaatcacca tttaagggga tggcattctt tatacctaaa     4500

cacctaagag ctgaagtcag gtcttttaat caggttagaa ttctaaatga tgccagagaa     4560

ggcttgggaa attgtacttc agcgtgatag cctgtgtctt cttaatttgc tgcaaaatat     4620

gtggtagaga aagaaaagga aacagaaaaa tcactctggg ttatatagca agagatgaag     4680

gagaatattt caacacaggg tttttgtgtt gacataggaa aagcctgatt cttggcaact     4740

gttgtagttt gtctttcagg ggtgaaggtc ccactgacaa cccctgttgt ggtgttccac     4800

acgctgtttg ttggggtagc ttccatcggc agtctggccc attgtcagtc atgcttcttc     4860

tggccgggga gattatagag agattgtttg aagattgggt tattattgaa agtctttttt     4920

tttgtttgtt ttgttttggt ttgtttgttt atctacactt gtttatgctg tgagccaaac     4980

ctctatttaa aaagttgata ctcactttca atattttatt tcatattatt atatatgtca     5040

tgatagttat cttgatgtaa atatgaagat ttttttgttt ctgtagatag taaactcttt     5100

ttttaaaaaa ggaaaaggga aacattttta taaagttata ttttaatcac catttttata     5160

cattgtagtt ctctccaagc ccagtaagag aatgatgatt catttgcatg gaggtcgatg     5220

gacaaccaat catctacctt ttctaattta aatgataatc tgatatagtt ttattgccag     5280

ttaaatgagg atgctgcaaa gcatgttttt tcactagtaa cttttgctaa ctgaatgaat     5340

tctgggtcca tatctcccag atgaaaaact gttaaccaat accatatttt atagttggtg     5400

tccatttctt tccaacactg tttgttatga ttcttccttg agtacttata tacagacctg     5460

ctcattatct aaacaatctt accttctaag taaaccttga ttgtgatttc cagtttttat     5520

tttctctgac gtagtagaaa ggaatgttta cattaaaaat acttttgttt ctcataaatg     5580

gatattgtac tccccccttt caaagcatta ttttacaata attcatggca ttttaaaaaa     5640

taaggcaaag ataatacgac aaaaaatata catggtttca aggcaaattc tccaataagt     5700

tggaaaatgt aaaaaggatc aagtggatgc agcctctacc taaataatta aaatatattt     5760

cagtatattt ctgaattaac accaggtctt cattatttag aacttactaa attgttttca     5820

ttttcttagt tttacctgtg tatctccatg tttgcaaaaa ttactataag tcaaattttg     5880

ccagtgaatt taactatttt tctttccttg caattaaggg gaaaaaagca tttatcttat     5940

cttctcatac cccttgcatc taagtactta gcaaagtcaa tattttccca ttttccaaat     6000

gcgtccatct ctaacataaa tattaattga acatagagct atgtttggag tgagtggact     6060

ggcaggacag ttggaagtcc atcacagtct attgacagtt tcatcaaagc tgtatagtcc     6120

aactagtggg gcagcttggc tactatggtg gaagtctcag caaactgcct ggttttgttt     6180

gtttgttttg ttttaaggta caggaaataa gaggaataat agtggccaaa gcaattagaa     6240

catcttcatt ccagaactgt gttcagcaat ccaggcagat tgatacattt ttctttaaaa     6300

ataaattgct attacagcta gacgtcaatt gggataaata aagggatgaa gatccactaa     6360

gtttgtgact ttcatacaca cccagtacat ctcaaaggat gctaagggac attttctgcc     6420

agtagagttc tccccctttt tggtgacagc aatattatta tgttcacatc taactccaga     6480

gcttacttcc tgtggtgcca atgtatttgt tgcaatttac tacattttta tatgagccta     6540

tttataggtg ccattaaact caggtctttc aaatgaaaga gtttctagcc cacttaggga     6600

aaaagataat tgtttagaaa accataaaat caatggtagg aaaagttgga actggttacc     6660

tggatgccat ggttctctgt taaataaagt aagagaccag gtgtattctg agtgtcatca     6720

gtgttatttt cagcatgcta ataaatgtct ttccggttat atatctatct aaattaacct     6780

ttaaaatatt ggtttccttg ataaaagcac cacttttgct tttgttagct gtaatatttt     6840

ttgtcattta gataagacct ggtttggctc tcaataaaag atgaagacag tagctctgta     6900

cagggatata tctatattag tcttcatctg atgaatgaag aaattttctc atattatgtt     6960

caagaaagta tttacttcct aaaaatagaa ttcccgattc tgtctatttt ggttgaatac     7020

cagaacaaat ctttccgttg caatcccagt aaaacgaaag aaaaggaata tcttacagac     7080

tgttcatatt agatgtatgt agactgttaa tttgcaattt ccccatattt cctgcctatc     7140

ttacccagat aactttcttt gaaggtaaaa gctgtgcaaa aggcatgaga ctcaggccta     7200

ctctttgttt aaatgatgga aaaatataaa ttattttcta agtaataaaa gtataaaaat     7260

tatcattata aataaagtct aaagtttgaa attattaatt taaaaaaaaa aaaaaaaaa      7319


<210> 2
<211> 1141
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Val Pro Gly Asp Ala Ala Arg Val Arg Asp Lys Pro Val His 
1               5                   10                  15      


Ser Gly Val Ser Gln Ala Pro Thr Ala Gly Arg Asp Cys His His Arg 
            20                  25                  30          


Ala Asp Pro Ala Ser Pro Arg Asp Ser Gly Cys Arg Gly Cys Trp Gly 
        35                  40                  45              


Asp Leu Val Leu Gln Pro Leu Arg Ser Ser Arg Lys Leu Ser Ser Ala 
    50                  55                  60                  


Leu Cys Ala Gly Ser Leu Ser Phe Leu Leu Ala Leu Leu Val Arg Leu 
65                  70                  75                  80  


Val Arg Gly Glu Val Gly Cys Asp Leu Glu Gln Cys Lys Glu Ala Ala 
                85                  90                  95      


Ala Ala Glu Glu Glu Glu Ala Ala Pro Gly Ala Glu Gly Gly Val Phe 
            100                 105                 110         


Pro Gly Pro Arg Gly Gly Ala Pro Gly Gly Gly Ala Arg Leu Ser Pro 
        115                 120                 125             


Trp Leu Gln Pro Ser Ala Leu Leu Phe Ser Leu Leu Cys Ala Phe Phe 
    130                 135                 140                 


Trp Met Gly Leu Tyr Leu Leu Arg Ala Gly Val Arg Leu Pro Leu Ala 
145                 150                 155                 160 


Val Ala Leu Leu Ala Ala Cys Cys Gly Gly Glu Ala Leu Val Gln Ile 
                165                 170                 175     


Gly Leu Gly Val Gly Glu Asp His Leu Leu Ser Leu Pro Ala Ala Gly 
            180                 185                 190         


Val Val Leu Ser Cys Leu Ala Ala Ala Thr Trp Leu Val Leu Arg Leu 
        195                 200                 205             


Arg Leu Gly Val Leu Met Ile Ala Leu Thr Ser Ala Val Arg Thr Val 
    210                 215                 220                 


Ser Leu Ile Ser Leu Glu Arg Phe Lys Val Ala Trp Arg Pro Tyr Leu 
225                 230                 235                 240 


Ala Tyr Leu Ala Gly Val Leu Gly Ile Leu Leu Ala Arg Tyr Val Glu 
                245                 250                 255     


Gln Ile Leu Pro Gln Ser Ala Glu Ala Ala Pro Arg Glu His Leu Gly 
            260                 265                 270         


Ser Gln Leu Ile Ala Gly Thr Lys Glu Asp Ile Pro Val Phe Lys Arg 
        275                 280                 285             


Arg Arg Arg Ser Ser Ser Val Val Ser Ala Glu Met Ser Gly Cys Ser 
    290                 295                 300                 


Ser Lys Ser His Arg Arg Thr Ser Leu Pro Cys Ile Pro Arg Glu Gln 
305                 310                 315                 320 


Leu Met Gly His Ser Glu Trp Asp His Lys Arg Gly Pro Arg Gly Ser 
                325                 330                 335     


Gln Ser Ser Gly Thr Ser Ile Thr Val Asp Ile Ala Val Met Gly Glu 
            340                 345                 350         


Ala His Gly Leu Ile Thr Asp Leu Leu Ala Asp Pro Ser Leu Pro Pro 
        355                 360                 365             


Asn Val Cys Thr Ser Leu Arg Ala Val Ser Asn Leu Leu Ser Thr Gln 
    370                 375                 380                 


Leu Thr Phe Gln Ala Ile His Lys Pro Arg Val Asn Pro Val Thr Ser 
385                 390                 395                 400 


Leu Ser Glu Asn Tyr Thr Cys Ser Asp Ser Glu Glu Ser Ser Glu Lys 
                405                 410                 415     


Asp Lys Leu Ala Ile Pro Lys Arg Leu Arg Arg Ser Leu Pro Pro Gly 
            420                 425                 430         


Leu Leu Arg Arg Val Ser Ser Thr Trp Thr Thr Thr Thr Ser Ala Thr 
        435                 440                 445             


Gly Leu Pro Thr Leu Glu Pro Ala Pro Val Arg Arg Asp Arg Ser Thr 
    450                 455                 460                 


Ser Ile Lys Leu Gln Glu Ala Pro Ser Ser Ser Pro Asp Ser Trp Asn 
465                 470                 475                 480 


Asn Pro Val Met Met Thr Leu Thr Lys Ser Arg Ser Phe Thr Ser Ser 
                485                 490                 495     


Tyr Ala Ile Ser Ala Ala Asn His Val Lys Ala Lys Lys Gln Ser Arg 
            500                 505                 510         


Pro Gly Ala Leu Ala Lys Ile Ser Pro Leu Ser Ser Pro Cys Ser Ser 
        515                 520                 525             


Pro Leu Gln Gly Thr Pro Ala Ser Ser Leu Val Ser Lys Ile Ser Ala 
    530                 535                 540                 


Val Gln Phe Pro Glu Ser Ala Asp Thr Thr Ala Lys Gln Ser Leu Gly 
545                 550                 555                 560 


Ser His Arg Ala Leu Thr Tyr Thr Gln Ser Ala Pro Asp Leu Ser Pro 
                565                 570                 575     


Gln Ile Leu Thr Pro Pro Val Ile Cys Ser Ser Cys Gly Arg Pro Tyr 
            580                 585                 590         


Ser Gln Gly Asn Pro Ala Asp Glu Pro Leu Glu Arg Ser Gly Val Ala 
        595                 600                 605             


Thr Arg Thr Pro Ser Arg Thr Asp Asp Thr Ala Gln Val Thr Ser Asp 
    610                 615                 620                 


Tyr Glu Thr Asn Asn Asn Ser Asp Ser Ser Asp Ile Val Gln Asn Glu 
625                 630                 635                 640 


Asp Glu Thr Glu Cys Leu Arg Glu Pro Leu Arg Lys Ala Ser Ala Cys 
                645                 650                 655     


Ser Thr Tyr Ala Pro Glu Thr Met Met Phe Leu Asp Lys Pro Ile Leu 
            660                 665                 670         


Ala Pro Glu Pro Leu Val Met Asp Asn Leu Asp Ser Ile Met Glu Gln 
        675                 680                 685             


Leu Asn Thr Trp Asn Phe Pro Ile Phe Asp Leu Val Glu Asn Ile Gly 
    690                 695                 700                 


Arg Lys Cys Gly Arg Ile Leu Ser Gln Val Ser Tyr Arg Leu Phe Glu 
705                 710                 715                 720 


Asp Met Gly Leu Phe Glu Ala Phe Lys Ile Pro Ile Arg Glu Phe Met 
                725                 730                 735     


Asn Tyr Phe His Ala Leu Glu Ile Gly Tyr Arg Asp Ile Pro Tyr His 
            740                 745                 750         


Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu Thr 
        755                 760                 765             


Thr Gln Pro Ile Pro Gly Leu Ser Thr Val Ile Asn Asp His Gly Ser 
    770                 775                 780                 


Thr Ser Asp Ser Asp Ser Asp Ser Gly Phe Thr His Gly His Met Gly 
785                 790                 795                 800 


Tyr Val Phe Ser Lys Thr Tyr Asn Val Thr Asp Asp Lys Tyr Gly Cys 
                805                 810                 815     


Leu Ser Gly Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val Ala 
            820                 825                 830         


Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe Leu 
        835                 840                 845             


Val Ala Thr Ser Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser Val 
    850                 855                 860                 


Leu Glu Asn His His Ala Ala Ala Ala Trp Asn Leu Phe Met Ser Arg 
865                 870                 875                 880 


Pro Glu Tyr Asn Phe Leu Ile Asn Leu Asp His Val Glu Phe Lys His 
                885                 890                 895     


Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys Lys 
            900                 905                 910         


His Phe Asp Phe Val Ala Lys Phe Asn Gly Lys Val Asn Asp Asp Val 
        915                 920                 925             


Gly Ile Asp Trp Thr Asn Glu Asn Asp Arg Leu Leu Val Cys Gln Met 
    930                 935                 940                 


Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Cys Lys Glu Leu 
945                 950                 955                 960 


His Leu Gln Trp Thr Asp Gly Ile Val Asn Glu Phe Tyr Glu Gln Gly 
                965                 970                 975     


Asp Glu Glu Ala Ser Leu Gly Leu Pro Ile Ser Pro Phe Met Asp Arg 
            980                 985                 990         


Ser Ala Pro Gln Leu Ala Asn Leu  Gln Glu Ser Phe Ile  Ser His Ile 
        995                 1000                 1005             


Val Gly  Pro Leu Cys Asn Ser  Tyr Asp Ser Ala Gly  Leu Met Pro 
    1010                 1015                 1020             


Gly Lys  Trp Val Glu Asp Ser  Asp Glu Ser Gly Asp  Thr Asp Asp 
    1025                 1030                 1035             


Pro Glu  Glu Glu Glu Glu Glu  Ala Pro Ala Pro Asn  Glu Glu Glu 
    1040                 1045                 1050             


Thr Cys  Glu Asn Asn Glu Ser  Pro Lys Lys Lys Thr  Phe Lys Arg 
    1055                 1060                 1065             


Arg Lys  Ile Tyr Cys Gln Ile  Thr Gln His Leu Leu  Gln Asn His 
    1070                 1075                 1080             


Lys Met  Trp Lys Lys Val Ile  Glu Glu Glu Gln Arg  Leu Ala Gly 
    1085                 1090                 1095             


Ile Glu  Asn Gln Ser Leu Asp  Gln Thr Pro Gln Ser  His Ser Ser 
    1100                 1105                 1110             


Glu Gln  Ile Gln Ala Ile Lys  Glu Glu Glu Glu Glu  Lys Gly Lys 
    1115                 1120                 1125             


Pro Arg  Gly Glu Glu Ile Pro  Thr Gln Lys Pro Asp  Gln 
    1130                 1135                 1140     


<210> 3
<211> 819
<212> PRT
<213> Homo sapiens

<400> 3
Met Val Thr Ile Phe Ser Lys Ser Trp Ser Phe Tyr Trp Glu Lys Ser 
1               5                   10                  15      


Ser Gly Thr Ser Ile Thr Val Asp Ile Ala Val Met Gly Glu Ala His 
            20                  25                  30          


Gly Leu Ile Thr Asp Leu Leu Ala Asp Pro Ser Leu Pro Pro Asn Val 
        35                  40                  45              


Cys Thr Ser Leu Arg Ala Val Ser Asn Leu Leu Ser Thr Gln Leu Thr 
    50                  55                  60                  


Phe Gln Ala Ile His Lys Pro Arg Val Asn Pro Val Thr Ser Leu Ser 
65                  70                  75                  80  


Glu Asn Tyr Thr Cys Ser Asp Ser Glu Glu Ser Ser Glu Lys Asp Lys 
                85                  90                  95      


Leu Ala Ile Pro Lys Arg Leu Arg Arg Ser Leu Pro Pro Gly Leu Leu 
            100                 105                 110         


Arg Arg Val Ser Ser Thr Trp Thr Thr Thr Thr Ser Ala Thr Gly Leu 
        115                 120                 125             


Pro Thr Leu Glu Pro Ala Pro Val Arg Arg Asp Arg Ser Thr Ser Ile 
    130                 135                 140                 


Lys Leu Gln Glu Ala Pro Ser Ser Ser Pro Asp Ser Trp Asn Asn Pro 
145                 150                 155                 160 


Val Met Met Thr Leu Thr Lys Ser Arg Ser Phe Thr Ser Ser Tyr Ala 
                165                 170                 175     


Ile Ser Ala Ala Asn His Val Lys Ala Lys Lys Gln Ser Arg Pro Gly 
            180                 185                 190         


Ala Leu Ala Lys Ile Ser Pro Leu Ser Ser Pro Cys Ser Ser Pro Leu 
        195                 200                 205             


Gln Gly Thr Pro Ala Ser Ser Leu Val Ser Lys Ile Ser Ala Val Gln 
    210                 215                 220                 


Phe Pro Glu Ser Ala Asp Thr Thr Ala Lys Gln Ser Leu Gly Ser His 
225                 230                 235                 240 


Arg Ala Leu Thr Tyr Thr Gln Ser Ala Pro Asp Leu Ser Pro Gln Ile 
                245                 250                 255     


Leu Thr Pro Pro Val Ile Cys Ser Ser Cys Gly Arg Pro Tyr Ser Gln 
            260                 265                 270         


Gly Asn Pro Ala Asp Glu Pro Leu Glu Arg Ser Gly Val Ala Thr Arg 
        275                 280                 285             


Thr Pro Ser Arg Thr Asp Asp Thr Ala Gln Val Thr Ser Asp Tyr Glu 
    290                 295                 300                 


Thr Asn Asn Asn Ser Asp Ser Ser Asp Ile Val Gln Asn Glu Asp Glu 
305                 310                 315                 320 


Thr Glu Cys Leu Arg Glu Pro Leu Arg Lys Ala Ser Ala Cys Ser Thr 
                325                 330                 335     


Tyr Ala Pro Glu Thr Met Met Phe Leu Asp Lys Pro Ile Leu Ala Pro 
            340                 345                 350         


Glu Pro Leu Val Met Asp Asn Leu Asp Ser Ile Met Glu Gln Leu Asn 
        355                 360                 365             


Thr Trp Asn Phe Pro Ile Phe Asp Leu Val Glu Asn Ile Gly Arg Lys 
    370                 375                 380                 


Cys Gly Arg Ile Leu Ser Gln Val Ser Tyr Arg Leu Phe Glu Asp Met 
385                 390                 395                 400 


Gly Leu Phe Glu Ala Phe Lys Ile Pro Ile Arg Glu Phe Met Asn Tyr 
                405                 410                 415     


Phe His Ala Leu Glu Ile Gly Tyr Arg Asp Ile Pro Tyr His Asn Arg 
            420                 425                 430         


Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu Thr Thr Gln 
        435                 440                 445             


Pro Ile Pro Gly Leu Ser Thr Val Ile Asn Asp His Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Asp Ser Asp Ser Gly Phe Thr His Gly His Met Gly Tyr Val 
465                 470                 475                 480 


Phe Ser Lys Thr Tyr Asn Val Thr Asp Asp Lys Tyr Gly Cys Leu Ser 
                485                 490                 495     


Gly Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val Ala Ala Ala 
            500                 505                 510         


Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe Leu Val Ala 
        515                 520                 525             


Thr Ser Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser Val Leu Glu 
    530                 535                 540                 


Asn His His Ala Ala Ala Ala Trp Asn Leu Phe Met Ser Arg Pro Glu 
545                 550                 555                 560 


Tyr Asn Phe Leu Ile Asn Leu Asp His Val Glu Phe Lys His Phe Arg 
                565                 570                 575     


Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys Lys His Phe 
            580                 585                 590         


Asp Phe Val Ala Lys Phe Asn Gly Lys Val Asn Asp Asp Val Gly Ile 
        595                 600                 605             


Asp Trp Thr Asn Glu Asn Asp Arg Leu Leu Val Cys Gln Met Cys Ile 
    610                 615                 620                 


Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Cys Lys Glu Leu His Leu 
625                 630                 635                 640 


Gln Trp Thr Asp Gly Ile Val Asn Glu Phe Tyr Glu Gln Gly Asp Glu 
                645                 650                 655     


Glu Ala Ser Leu Gly Leu Pro Ile Ser Pro Phe Met Asp Arg Ser Ala 
            660                 665                 670         


Pro Gln Leu Ala Asn Leu Gln Glu Ser Phe Ile Ser His Ile Val Gly 
        675                 680                 685             


Pro Leu Cys Asn Ser Tyr Asp Ser Ala Gly Leu Met Pro Gly Lys Trp 
    690                 695                 700                 


Val Glu Asp Ser Asp Glu Ser Gly Asp Thr Asp Asp Pro Glu Glu Glu 
705                 710                 715                 720 


Glu Glu Glu Ala Pro Ala Pro Asn Glu Glu Glu Thr Cys Glu Asn Asn 
                725                 730                 735     


Glu Ser Pro Lys Lys Lys Thr Phe Lys Arg Arg Lys Ile Tyr Cys Gln 
            740                 745                 750         


Ile Thr Gln His Leu Leu Gln Asn His Lys Met Trp Lys Lys Val Ile 
        755                 760                 765             


Glu Glu Glu Gln Arg Leu Ala Gly Ile Glu Asn Gln Ser Leu Asp Gln 
    770                 775                 780                 


Thr Pro Gln Ser His Ser Ser Glu Gln Ile Gln Ala Ile Lys Glu Glu 
785                 790                 795                 800 


Glu Glu Glu Lys Gly Lys Pro Arg Gly Glu Glu Ile Pro Thr Gln Lys 
                805                 810                 815     


Pro Asp Gln 
            


<210> 4
<211> 6091
<212> DNA
<213> Homo sapiens

<400> 4
gctcgcgcgc ccaacggacc aggctggggc cgtgaggtaa ctgttgcagc cagcggaggt       60

gggaggcgac actgagtctc cagtcccgag aggtgcccga gggaaaagga ggcggcagct      120

aaactggtcc tggagagaag ccccttccgc ccctctcctc agccagcatg tcccggactc      180

cgccgctcct cagtccgcgc ggtggggacc ccgggccgtg gcggccggcg cagccctgac      240

gggttgcgaa ccagggggcg ccccgaacgc gggggttggg gtctgggagc gcgagcggcc      300

gctacggtac gagcggggtg tgctgagtcc cgtggccacc cccggcccca gccatgagga      360

gggacgagcg agacgccaaa gccatgcggt ccctgcagcc gccggatggg gccggctcgc      420

cccccgagag tctgaggaac ggctacgtga agagctgcgt gagccccttg cggcaggacc      480

ctccgcgcgg cttcttcttc cacctctgcc gcttctgcaa cgtggagctg cggccgccgc      540

cggcctctcc ccagcagccg cggcgctgct cccccttctg ccgggcgcgc ctctcgctgg      600

gcgccctggc tgcctttgtc ctcgccctgc tgctgggcgc ggaacccgag agctgggctg      660

ccggggccgc ctggctgcgg acgctgctga gcgtgtgttc gcacagcttg agccccctct      720

tcagcatcgc ctgtgccttc ttcttcctca cctgcttcct cacccggacc aagcggggac      780

ccggcccggg ccggagctgc ggctcctggt ggctgctggc gctgcccgcc tgctgttacc      840

tgggggactt cttggtgtgg cagtggtggt cttggccttg gggggatggc gacgcagggt      900

ccgcggcccc gcacacgccc ccggaggcgg cagcgggcag gttgctgctg gtgctgagct      960

gcgtagggct gctgctgacg ctcgcgcacc cgctgcggct ccggcactgc gttctggtgc     1020

tgctcctggc cagcttcgtc tggtgggtct ccttcaccag cctcgggtcg ctgccctccg     1080

ccctcaggcc gctgctctcc ggcctggtgg ggggcgctgg ctgcctgctg gccctggggt     1140

tggatcactt ctttcaaatc agggaagcgc ctcttcatcc tcgactgtcc agtgccgccg     1200

aagaaaaagt gcctgtgatc cgaccccgga ggaggtccag ctgcgtgtcg ttaggagaaa     1260

ctgcagccag ttactatggc agttgcaaaa tattcaggag accgtcgttg ccttgtattt     1320

ccagagaaca gatgattctt tgggattggg acttaaaaca atggtataag cctcattatc     1380

aaaattctgg aggtggaaat ggagttgatc tttcagtgct aaatgaggct cgcaatatgg     1440

tgtcagatct tctgactgat ccaagccttc caccacaagt catttcctct ctacggagta     1500

ttagtagctt aatgggtgct ttctcaggtt cctgtaggcc aaagattaat cctctcacac     1560

catttcctgg attttacccc tgttctgaaa tagaggaccc agctgagaaa ggggatagaa     1620

aacttaacaa gggactaaat aggaatagtt tgccaactcc acagctgagg agaagctcag     1680

gaacttcagg attgctacct gttgaacagt cttcaaggtg ggatcgtaat aatggcaaaa     1740

gacctcacca agaatttggc atttcaagtc aaggatgcta tctaaatggg ccttttaatt     1800

caaatctact gactatcccg aagcaaaggt catcttctgt atcactgact caccatgtag     1860

gtctcagaag agctggtgtt ttgtccagtc tgagtcctgt gaattcttcc aaccatggac     1920

cagtgtctac tggctctcta actaatcgat cacccataga atttcctgat actgctgatt     1980

ttcttaataa gccaagcgtt atcttgcaga gatctctggg caatgcacct aatactccag     2040

atttttatca gcaacttaga aattctgata gcaatctgtg taacagctgt ggacatcaaa     2100

tgctgaaata tgtttcaaca tctgaatcag atggtacaga ttgctgcagt ggaaaatcag     2160

gtgaagaaga aaacattttc tcgaaagaat cattcaaact tatggaaact caacaagaag     2220

aggaaacaga gaagaaagac agcagaaaat tatttcagga aggtgataag tggctaacag     2280

aagaggcaca gagtgaacag caaacaaata ttgaacagga agtatcactg gacctgattt     2340

tagtagaaga gtatgactca ttaatagaaa agatgagcaa ctggaatttt ccaatttttg     2400

aacttgtaga aaagatggga gagaaatcag gaaggattct cagtcaggtt atgtatacct     2460

tatttcaaga cactggttta ttggaaatat ttaaaattcc cactcaacaa tttatgaact     2520

attttcgtgc attagaaaat ggctatcgag acattcctta tcacaatcgt atacatgcca     2580

cagatgtgct acatgcagtt tggtatctga caacacggcc agttcctggc ttacagcaga     2640

tccacaatgg ttgtggaaca ggaaatgaaa cagattctga tggtagaatt aaccatgggc     2700

gaattgctta tatttcttcg aagagctgct ctaatcctga tgagagttat ggctgcctgt     2760

cttcaaacat tcctgcatta gaattgatgg ctctatacgt ggcagctgcc atgcatgatt     2820

atgatcaccc agggaggaca aatgcatttc tagtggctac aaatgcccct caggcagttt     2880

tatacaatga cagatctgtt ctggaaaatc atcatgctgc gtcagcttgg aatctatatc     2940

tttctcgccc agaatacaac ttccttcttc atcttgatca tgtggaattc aagcgctttc     3000

gttttttagt cattgaagca atccttgcta cggatcttaa aaagcatttt gattttctcg     3060

cagaattcaa tgccaaggca aatgatgtaa atagtaatgg catagaatgg agtaatgaaa     3120

atgatcgcct cttggtatgc caggtgtgca tcaaactggc agatataaat ggcccagcaa     3180

aagttcgaga cttgcatttg aaatggacag aaggcattgt caatgaattt tatgagcagg     3240

gagatgaaga agcaaatctt ggtctgccca tcagtccatt catggatcgt tcttctcctc     3300

aactagcaaa actccaagaa tcttttatca cccacatagt gggtcccctg tgtaactcct     3360

atgatgctgc tggtttgcta ccaggtcagt ggttagaagc agaagaggat aatgatactg     3420

aaagtggtga tgatgaagac ggtgaagaat tagatacaga agatgaagaa atggaaaaca     3480

atctaaatcc aaaaccacca agaaggaaaa gcagacggcg aatattttgt cagctaatgc     3540

accacctcac tgaaaaccac aagatatgga aggaaatcgt agaggaagaa gaaaaatgta     3600

aagctgatgg gaataaactg caggtggaga attcctcctt acctcaagca gatgagattc     3660

aggtaattga agaggcagat gaagaggaat agcgacagtt tgagtaaaag aaaagtcata     3720

ttgaagaagc ccagagggtt gtgcccaggg gcagaaatca ttgcctagtg ttcaccggct     3780

gactctcaac tgaccattcc catgtggaca ggccttaata ctgtgagagg atccttgctc     3840

tgctggcagt ttcccactcc tatgcacttt cacaggaact agaaaactat tcttaaacca     3900

aaaataccat ccgtgttgac ccatgttgca gagcccttac ttaaatcctt cactggtgta     3960

tgaatacttt gtcataatgc tgctttgctg ggtagtgagc tcttattttt cactgggggt     4020

cagctataac taaaaactca agtgacatat ttcagttacc aaagtggcca ggaacttttt     4080

gcttttatga aaatagattc atattgtatt tcccagtgtg tcttttatgt ctttgaatgt     4140

tttggagaaa agtctatgcc tgtctaaaaa tgaatccagt gttgcctttc tgagggattt     4200

ctgctcaatg caatacactg ttcagtgcta ttctcccagc taggtttatc catgaaggac     4260

tgagtgacct ttgttgtatt taacaaaatc caggtgcatc aatttctgat gctttttact     4320

attgtgtatt atctactatg tgtgttttat ttctgctgag agtattcagg tttgccatgg     4380

acatcagaag tttgaattcc agtcttatct tatgttccat ggctgaattt taaagctgtt     4440

taggtttaac aatgaaggga tttattcttt agtcaaaatt gttgttttta ctctagctca     4500

ggattcgtat ttttaaagat ttagttaata tgaacacagc acagatttgt tagaagaaaa     4560

aaaatttgct gtaataccaa aactaacctc atcaaagata cagaaaaaaa gaaatatagt     4620

gagccctaaa ggacacatac attgaataaa taattggaac atgtggttat ctttagatcc     4680

acatcttagc tgtcatttgt tcactctaaa actgatgttc atctttctgt taatttccct     4740

ctgcctaaag actacatgac agaaatgacc tatcactact tattatttct gaagcctaac     4800

tgcaagactg atttctgaga acaagtaaag aactggaata cttatttttc atataaaaat     4860

ctaaatgtgt taataaatca tttcatacaa aagtacatta ttaaataacc acattattaa     4920

aataattgca agaaaatgga ccatatttac aatgttttgt aaacttgcta gtgtgtggat     4980

atgtacccta cttgtgaaat acatttgaag atataaagag cagccaaaat gatggcaaaa     5040

tggtaggcta atattttcta ttattattgg agaacatatc atattttgga atcatgcaat     5100

tttgcacaca gtgaaaccat taattttcca aggtaattcc tttagaatat ggtattggca     5160

tgcagtttct tacttatcta gaatatttgg cttatctgaa agatatcaat ttaagatctc     5220

tggaagtgtt agaatttttg atccttcaca gtgtcaatat ttaatgaatc actaagcttt     5280

atttattaga cgtgttgagt gagtgctgag ttccttgctg ccacttttgt taccattgtc     5340

acacactatg tgtaaaccag tcccaccact tattactaat aaaattttga ctgataattt     5400

atatttgcac ttacaatata tatatcctgt ccttatattt ctctagagta cattttccat     5460

catgtttaag tgtatttctg ctattatttc ctctcctgca gaatacatac aagtgtatgt     5520

gtataaagtc atacatgtac aagcatgcat attgagattg aatcacattt ccatactgtc     5580

tgttatttta ttgggtttta tattgggttt ctttagttta tgttgttttc tcaaaagcag     5640

cattttaaat tacgaatact ggacttattg gatttaatta taaatccaat tactactgga     5700

aactcatttt tacataatat agtccttaaa ttatttaacc cttgctaagt aattgacata     5760

tgtaacaata actagcctaa agaaacccaa aaaagtatct ctcccgagct gaaacttaaa     5820

aattcgtaag tgtaagaaag aatgtgagaa tatattaaat gcacactgta ccattagatg     5880

aaatcttact tgagaaattg ccataagcca tattacagat cttactttgt tactgaatca     5940

gattaatttc ttgttataat aattttcatc ataaattttc tatttttaaa gccgctggta     6000

ctagaaatat tcttttaatg ctatatctat gtacctactg acacattttt ctccataaaa     6060

gtacttttaa aaattacttc atgatttgaa a                                    6091


<210> 5
<211> 1112
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro 
1               5                   10                  15      


Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val 
            20                  25                  30          


Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe 
        35                  40                  45              


Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala 
    50                  55                  60                  


Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu 
65                  70                  75                  80  


Ser Leu Gly Ala Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala 
                85                  90                  95      


Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu 
            100                 105                 110         


Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala 
        115                 120                 125             


Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly 
    130                 135                 140                 


Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys 
145                 150                 155                 160 


Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp 
                165                 170                 175     


Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala 
            180                 185                 190         


Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu 
        195                 200                 205             


Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu 
    210                 215                 220                 


Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu 
225                 230                 235                 240 


Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly 
                245                 250                 255     


Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala 
            260                 265                 270         


Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val 
        275                 280                 285             


Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala 
    290                 295                 300                 


Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro 
305                 310                 315                 320 


Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln 
                325                 330                 335     


Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp 
            340                 345                 350         


Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr 
        355                 360                 365             


Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser 
    370                 375                 380                 


Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro 
385                 390                 395                 400 


Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro 
                405                 410                 415     


Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser 
            420                 425                 430         


Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu 
        435                 440                 445             


Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro 
    450                 455                 460                 


His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro 
465                 470                 475                 480 


Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val 
                485                 490                 495     


Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser 
            500                 505                 510         


Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser 
        515                 520                 525             


Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu 
    530                 535                 540                 


Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn 
545                 550                 555                 560 


Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys 
                565                 570                 575     


Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser 
            580                 585                 590         


Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile 
        595                 600                 605             


Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu 
    610                 615                 620                 


Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp 
625                 630                 635                 640 


Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu 
                645                 650                 655     


Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu 
            660                 665                 670         


Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met 
        675                 680                 685             


Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe 
    690                 695                 700                 


Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe 
705                 710                 715                 720 


Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr 
                725                 730                 735     


His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu 
            740                 745                 750         


Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly 
        755                 760                 765             


Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile 
    770                 775                 780                 


Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly 
785                 790                 795                 800 


Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val 
                805                 810                 815     


Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe 
            820                 825                 830         


Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser 
        835                 840                 845             


Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser 
    850                 855                 860                 


Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys 
865                 870                 875                 880 


Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys 
                885                 890                 895     


Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val 
            900                 905                 910         


Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val 
        915                 920                 925             


Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val 
    930                 935                 940                 


Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr 
945                 950                 955                 960 


Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe 
                965                 970                 975     


Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile 
            980                 985                 990         


Thr His Ile Val Gly Pro Leu Cys  Asn Ser Tyr Asp Ala  Ala Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Gln Trp Leu Glu  Ala Glu Glu Asp Asn  Asp Thr Glu 
    1010                 1015                 1020             


Ser Gly  Asp Asp Glu Asp Gly  Glu Glu Leu Asp Thr  Glu Asp Glu 
    1025                 1030                 1035             


Glu Met  Glu Asn Asn Leu Asn  Pro Lys Pro Pro Arg  Arg Lys Ser 
    1040                 1045                 1050             


Arg Arg  Arg Ile Phe Cys Gln  Leu Met His His Leu  Thr Glu Asn 
    1055                 1060                 1065             


His Lys  Ile Trp Lys Glu Ile  Val Glu Glu Glu Glu  Lys Cys Lys 
    1070                 1075                 1080             


Ala Asp  Gly Asn Lys Leu Gln  Val Glu Asn Ser Ser  Leu Pro Gln 
    1085                 1090                 1095             


Ala Asp  Glu Ile Gln Val Ile  Glu Glu Ala Asp Glu  Glu Glu 
    1100                 1105                 1110         


<210> 6
<211> 2530
<212> DNA
<213> Homo sapiens

<400> 6
tttgtaactt cacttcagcc tcccattgat cgctttctgc aaccattcag actgatctcg       60

ggctcctatt tcatttacat tgtgtgcaca ccaagtaacc agtgggaaaa ctttagaggg      120

tacttaaacc ccagaaaatt ctgaaaccgg gctcttgagc cgctatcctc gggcctgctc      180

ccaccctgtg gagtgcactt tcgttttcaa taaatctctg cttttgttgc ttcattcttt      240

ccttgctttg tttgtgtgtt tgtccagttc tttgttcaac acgccaagaa cctggacact      300

cttcactggt aacatatttt ggcaagccaa ccaggagaaa agaatttctg cttggacact      360

gcatagctgc tgggaaaatg aacatcagtg ttgatttgga aacgaattat gccgagttgg      420

ttctagatgt gggaagagtc actcttggag agaacagtag gaaaaaaatg aaggattgta      480

aactgagaaa aaagcagaat gaaagtgtct cacgagctat gtgtgctctg ctcaattctg      540

gagggggagt gatcaaggct gaaattgaga atgaagacta tagttataca aaagatggaa      600

taggactaga tttggaaaat tcttttagta acattctgtt atttgttcct gagtacttag      660

acttcatgca gaatggtaac tactttctga tttttgtgaa gtcatggagc ttgaacacct      720

ctggtctgcg gattaccacc ttgagctcca atttgtacaa aagagatata acatctgcaa      780

aagtcatgaa tgccactgct gcactggagt tcctcaaaga catgaaaaag actagaggga      840

gattgtattt aagaccagaa ttgctggcaa agaggccctg tgttgatata caagaagaaa      900

ataacatgaa ggccttggcc ggggtttttt ttgatagaac agaacttgat cggaaagaaa      960

aattgacctt tactgaatcc acacatgttg aaattaaaaa cttctcgaca gaaaagttgt     1020

tacaacgaat taaagagatt ctccctcaat atgtttctgc atttgcaaat actgatggag     1080

gatatttgtt cattggttta aatgaagata aagaaataat tggctttaaa gcagagatga     1140

gtgacctcga tgacttagaa agagaaatcg aaaagtccat taggaagatg cctgtgcatc     1200

acttctgtat ggagaagaag aagataaatt attcatgcaa attccttgga gtatatgata     1260

aaggaagtct ttgtggatat gtctgtgcac tcagagtgga gcgcttctgc tgtgcagtgt     1320

ttgctaaaga gcctgattcc tggcatgtga aagataaccg tgtgatgcag ttgaccagga     1380

aggaatggat ccagttcatg gtggaggctg aaccaaaatt ttccagttca tatgaagagg     1440

tgatctctca aataaatacg tcattacctg ctccccacag ttggcctctt ttggaatggc     1500

aacggcagag acatcactgt ccagggctat caggaaggat aacgtatact ccagaaaacc     1560

tttgcagaaa actgttctta caacatgaag gacttaagca attaatatgt gaagaaatgg     1620

actctgtcag aaagggctca ctgatcttct ctaggagctg gtctgtggat ctgggcttgc     1680

aagagaacca caaagtcctc tgtgatgctc ttctgatttc ccaggacagt cctccagtcc     1740

tatacacctt ccacatggta caggatgagg agtttaaagg ctattctaca caaactgccc     1800

taaccttaaa gcagaagctg gcaaaaattg gtggttacac taaaaaagtg tgtgtcatga     1860

caaagatctt ctacttgagc cctgaaggca tgacaagctg ccagtatgat ttaaggtcgc     1920

aagtaattta ccctgaatcc tactatttta caagaaggaa atacttgctg aaagcccttt     1980

ttaaagcctt aaagagactc aagtctctga gagaccagtt ttcctttgca gaaaatctat     2040

accagataat cggtatagat tgctttcaga agaatgataa aaagatgttt aaatcttgtc     2100

gaaggctcac ctgatggaaa atggactggg ctactgagat atttttcatt atatatttga     2160

taacattctc taattctgtg aaaatatttc tttgaaaact ttgcaagtta agcaacttaa     2220

tgtgatgttg gataattggg ttttgtctat tttcacttct ccctaaataa tcttcacaga     2280

tattgtttga gggatattag gaaaattaat ttgttaactc gtctgtgcac agtattattt     2340

actctgtctg tagttcctga ataaattttc ttccatgctt gaactgggaa aattgcaaca     2400

cttttattct taatgacaac agtgaaaatc tcccagcata tacctagaaa acaattataa     2460

cttacaaaag attatccttg atgaaactca gaatttccac agtgggaatg aataagaagg     2520

caaaactcat                                                            2530


<210> 7
<211> 578
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn Ile Ser Val Asp Leu Glu Thr Asn Tyr Ala Glu Leu Val Leu 
1               5                   10                  15      


Asp Val Gly Arg Val Thr Leu Gly Glu Asn Ser Arg Lys Lys Met Lys 
            20                  25                  30          


Asp Cys Lys Leu Arg Lys Lys Gln Asn Glu Ser Val Ser Arg Ala Met 
        35                  40                  45              


Cys Ala Leu Leu Asn Ser Gly Gly Gly Val Ile Lys Ala Glu Ile Glu 
    50                  55                  60                  


Asn Glu Asp Tyr Ser Tyr Thr Lys Asp Gly Ile Gly Leu Asp Leu Glu 
65                  70                  75                  80  


Asn Ser Phe Ser Asn Ile Leu Leu Phe Val Pro Glu Tyr Leu Asp Phe 
                85                  90                  95      


Met Gln Asn Gly Asn Tyr Phe Leu Ile Phe Val Lys Ser Trp Ser Leu 
            100                 105                 110         


Asn Thr Ser Gly Leu Arg Ile Thr Thr Leu Ser Ser Asn Leu Tyr Lys 
        115                 120                 125             


Arg Asp Ile Thr Ser Ala Lys Val Met Asn Ala Thr Ala Ala Leu Glu 
    130                 135                 140                 


Phe Leu Lys Asp Met Lys Lys Thr Arg Gly Arg Leu Tyr Leu Arg Pro 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Arg Pro Cys Val Asp Ile Gln Glu Glu Asn Asn 
                165                 170                 175     


Met Lys Ala Leu Ala Gly Val Phe Phe Asp Arg Thr Glu Leu Asp Arg 
            180                 185                 190         


Lys Glu Lys Leu Thr Phe Thr Glu Ser Thr His Val Glu Ile Lys Asn 
        195                 200                 205             


Phe Ser Thr Glu Lys Leu Leu Gln Arg Ile Lys Glu Ile Leu Pro Gln 
    210                 215                 220                 


Tyr Val Ser Ala Phe Ala Asn Thr Asp Gly Gly Tyr Leu Phe Ile Gly 
225                 230                 235                 240 


Leu Asn Glu Asp Lys Glu Ile Ile Gly Phe Lys Ala Glu Met Ser Asp 
                245                 250                 255     


Leu Asp Asp Leu Glu Arg Glu Ile Glu Lys Ser Ile Arg Lys Met Pro 
            260                 265                 270         


Val His His Phe Cys Met Glu Lys Lys Lys Ile Asn Tyr Ser Cys Lys 
        275                 280                 285             


Phe Leu Gly Val Tyr Asp Lys Gly Ser Leu Cys Gly Tyr Val Cys Ala 
    290                 295                 300                 


Leu Arg Val Glu Arg Phe Cys Cys Ala Val Phe Ala Lys Glu Pro Asp 
305                 310                 315                 320 


Ser Trp His Val Lys Asp Asn Arg Val Met Gln Leu Thr Arg Lys Glu 
                325                 330                 335     


Trp Ile Gln Phe Met Val Glu Ala Glu Pro Lys Phe Ser Ser Ser Tyr 
            340                 345                 350         


Glu Glu Val Ile Ser Gln Ile Asn Thr Ser Leu Pro Ala Pro His Ser 
        355                 360                 365             


Trp Pro Leu Leu Glu Trp Gln Arg Gln Arg His His Cys Pro Gly Leu 
    370                 375                 380                 


Ser Gly Arg Ile Thr Tyr Thr Pro Glu Asn Leu Cys Arg Lys Leu Phe 
385                 390                 395                 400 


Leu Gln His Glu Gly Leu Lys Gln Leu Ile Cys Glu Glu Met Asp Ser 
                405                 410                 415     


Val Arg Lys Gly Ser Leu Ile Phe Ser Arg Ser Trp Ser Val Asp Leu 
            420                 425                 430         


Gly Leu Gln Glu Asn His Lys Val Leu Cys Asp Ala Leu Leu Ile Ser 
        435                 440                 445             


Gln Asp Ser Pro Pro Val Leu Tyr Thr Phe His Met Val Gln Asp Glu 
    450                 455                 460                 


Glu Phe Lys Gly Tyr Ser Thr Gln Thr Ala Leu Thr Leu Lys Gln Lys 
465                 470                 475                 480 


Leu Ala Lys Ile Gly Gly Tyr Thr Lys Lys Val Cys Val Met Thr Lys 
                485                 490                 495     


Ile Phe Tyr Leu Ser Pro Glu Gly Met Thr Ser Cys Gln Tyr Asp Leu 
            500                 505                 510         


Arg Ser Gln Val Ile Tyr Pro Glu Ser Tyr Tyr Phe Thr Arg Arg Lys 
        515                 520                 525             


Tyr Leu Leu Lys Ala Leu Phe Lys Ala Leu Lys Arg Leu Lys Ser Leu 
    530                 535                 540                 


Arg Asp Gln Phe Ser Phe Ala Glu Asn Leu Tyr Gln Ile Ile Gly Ile 
545                 550                 555                 560 


Asp Cys Phe Gln Lys Asn Asp Lys Lys Met Phe Lys Ser Cys Arg Arg 
                565                 570                 575     


Leu Thr 
        


<210> 8
<211> 8080
<212> DNA
<213> Homo sapiens

<400> 8
ttttggcttc tgccctcaac caaaatggcg ctagctcgga agctgccgag gtgctaggag       60

ttgccgaagc aagtccggaa gctaccgagc gagtccggaa gttgccgaaa gggagcagcg      120

gggaaggagg atggcggata tcatcgcaag actccgggag gacgggatcc aaaaacgtgt      180

gatacaggaa ggccgaggag agctcccgga ctttcaagat gggaccaagg ttcgtgtcta      240

ccctaccctt ctccccctct gcggcgtggt gcgcatgcga ggcgggagga ggccttaggc      300

gagaggttgc gcatgcccag agggcagcgt ccactgcccc taccgctcac atgcagaact      360

cgacgctgat tgggctgaat ttaagtaggg ggtgaattcg ggcctgtctg ccccgccccc      420

tggctcggcc ttgtagcagc attggtgggg gaggccgtca gtcatcacaa gcgggttggg      480

gttgggggtt gatctcagtg cttgggcaga ccccacgctg gaggaaaccc agggccggga      540

gtggtcctcg ggtatctggg tttcaaggct catgatcctt tgtagatgga agggccttct      600

gaaaacactt agaccaactg ccgctgttta gagtggaaaa ccaagaccct gggacgtgca      660

aagccggaga acgggcccag aggtcaggtc tcccagacag ggactcttta gcagccttcc      720

tgctgcacta ggggcttgtt gggacagatg agggttggga agtaaagaac ctcccacttt      780

tctccttttt gccaggcccc cagatccagc ccctctgccc gcttctcccc caacctacaa      840

ctccaggctt ccctgcttct cctgtagttg cctcctcccg gagtgctttt cccagctgcc      900

acttgtttgc agagtaggga acctcccagg ggcagcccct gtgcccagca gagcagtcag      960

gcaggacatg cacattgagc aaatgagcac atgccccctg gccagcaccg tgccgaatcg     1020

ggcagctaag catcctagcc cagtgcagta taagtgccct gagagcagag gggagctgca     1080

tggctggagt gatccgctgt atgaaaagat atcttctcta agaagagaca ggatgtgtgg     1140

tgtgggttca tgcccccatg tgctgggggg ttggtggcgt tggaagaagg ggctggcaag     1200

ggggatcctg gatggaacag acatcagaag gagagatgtg aacaatggca ccccaagatc     1260

agaaacaggt ggtgttaaat aaccaatcgc cagcactgat tgagtgctca ctattcgaac     1320

attgtgctac atgcttcaca cgtttatttc ctacaatgtg agataggtac tgttgttgat     1380

tccgttttac cgatgtggaa actgacttca gagatgcagc atggtgcggc agttaagagc     1440

gtgggctcct ctaaccatat cctgtcgaga gttcaatctc caaacctctt ttctctgcac     1500

ccacccccag tgttatctct aaaaactctc cctgcccgga ttactcccag atgcagctct     1560

ccagtcatta actgtctctt aaacctgata tatagctccc tactcaccat atccacctgg     1620

aagcctggtt ggcaactcac acttaacctg ctccacctga ggcttctccg tgtcagggga     1680

accaacaacc ttcccgttgt tcagggcaaa aaccttagca tctctgtggt cctcccagtc     1740

tcacatccaa catcacatcc tcaatatcca gccaggatct gagttctcac cacttctgcc     1800

atcactgctt gggtccaggc catcctcatc tccagcctgg gttactgcag cgacctctaa     1860

ctctcctgcc tcttttgtcc ctctgtggtc tgttctcgtc ccagcagccg agcccatgcc     1920

agattcaatt ccttttttgc tcggagccac tcagtggctt ccatcacaga gtgaaaaaca     1980

gaggcctcac catagcctac aggccctgtg aggtccaccc ctactgacct gggtgagctc     2040

ccctgctgac cctgtggtgt accccacccc ctccttcact ctgctctgcc acactggcat     2100

tgctgctctt gaacacatca tgcatttgaa acgggaagtt cccttgtctc cctcgcaggg     2160

cgtgcgatgg gggagtggct cgcttcttca gtgccccgct gctcagacct ctgggggagc     2220

atacagatgg gcaggctgtg ggctccgacc tcatggcagt gtctaggggt gaatatttac     2280

agctccgtgt gttctagggt gctcttttag tttgtctatg ggaggcttgt gttaaccagc     2340

tcaattagac ccccttcctt atcacaagga cagagggctt tctgtagtct ggggttttct     2400

tgccttgatg tactggagta ctggagaatt agatcacttg tgggcttgga gaatgattgc     2460

aaattttttt ttatttttta ttttattttt tttttctgag atggagtttc actcttgttg     2520

cccaggctgg agtgcaatgg cacaatctct gcctcccagg ttcaagcaat tctcctgcct     2580

cagcctccca agtagctgag attacatgtg cctgacacca ggcccggcta atttttaaaa     2640

atgtttttag tagagatggg cttttaccat gttggccaag ctggtttcaa acgccttttt     2700

tttttttttt ttttttgaga cggagtcttg ctctattgcc caagctggag tgcagtggca     2760

tgatctcggt tcactgcaac ctccaccttc tgggttcaag tgattctcct gcctcagcct     2820

cccaagtagc tgggattaca ggcacccgcc atcatggcca gctaattttt gtatttttag     2880

tagagacggg gttttgccac attggccagg ctggtcttga actcctgacc tcaggtgatc     2940

cacccgcctt ggagatggtc ttcccctggg gttgggccac ttggtggccc cacctctcct     3000

ctgactgccc cagccaaact ccgcctcttc ctgccagttg atgacctgcc agcgtgcagg     3060

tgcctgtcag tgtgatcttc tgcttcttgc tcccctgaca tcctctcaat gaccaggagc     3120

tcgtcttctg ctgatgggct cctctgacat ctggctgcct gtgggtctac cccctagggg     3180

tgttgggttt ttataggcac aggatagggg tgtggcaggc cagggtggtc ttgggaaatg     3240

caacatttgg gcaggaaatg cctgttctca cctaggtctg tgggggtgga accctaccca     3300

gggaccacgc cctcctctac ccagcacttc ccttctcccc ttccaaatta tttaacagga     3360

ccatgctcct cccttcccag cacttccata tcacattgtc ccactgcaag gcttttttac     3420

acatgctgtt cttttggcct agaaagttcc tatcccaggg tccacttggc ttgctttctt     3480

ccttactccc caacccccca ctctgtttaa tccagcccca accctcttgc cctgctgttt     3540

cccaagcacg tggcttcacc tgccatgaca tattgttttg tttgatgccc atctcctccc     3600

tctagaagcg ccatgtgagc tccagggggg cagggacttt tttgtgtttt gcttgctgcc     3660

atgttctggt gtctagcaca gagcttgggc acatagtagg tgcttagtaa atatctgttg     3720

aggaatgact ggagtcagac tgcttggact cttgttccca ctcagccacc cactagccgt     3780

gtggcttggg cctattcctc ccctccttgt ggctttgttt tctcaccagc gtgggaggat     3840

gaagccaggt gtaaggtcag gtggtgtccc cggggaagcc ccgtccctta tgccgtctgc     3900

aggccgggga ctggacttct ccttgggggt cagggtgagg gtttgtgcct ttgcctgacc     3960

tcgcatgtgg cccacaggcc acgttccact accggacgct gcacagtgac gacgagggca     4020

ccgtgctgga cgacagccgg gctcgtggca agcccatgga gctcatcatt ggcaagaagt     4080

tcaagctgcc tgtgtgggag accatcgtgt gcaccatgcg agaaggggag attgcccagt     4140

tcctctgtga catcaaggtg tctgtcctgt acctgtctgc ggtggctgtc cagccaagcc     4200

ctattcctat tccctatccc cagggctcct cctccctcca ccctctgcta gactgccacc     4260

cgctttcttt ttttttttga gatggagtct tgctctgtcg cccaggctgg agtgcagtgg     4320

tacgatctca gctcactgca ccctccacct cctgggttca agcgattctt ctgcctcagc     4380

ctcccgagta gctgggatta caaacacccg ccatgatgcc tggctaattt ttgtattttt     4440

agtagagaca gggtttcacc atgttggcca ggctggtctt gaacacctga cctcaggtga     4500

tccacccgcc ttggcctccc aaagtgctgg gattataggc gtgtgccacc gcgcccggcc     4560

cacccactct ttccagacca ccacaccagc ctgctgatgg cgtcctggcc tccattccgc     4620

cttcccctat tagccagact gaggccaggg gactcgttct caaatgcaaa tgacctgtac     4680

atccctttgt ttcaaacctc tatgactcct ggtcactgta aggatagagc acagggggtc     4740

ctcacttcat gttgctgata cattcttgga aactgtgact aagagaaaaa acatacatca     4800

ggttttttct cagccaccgt catttctctc agcaaaattt tgttagaaca ttgatgagaa     4860

gaaaaattgg tttcgttatg tattgtttcg cctacagtca cagtttccaa gaacctactt     4920

aggacgttaa gtgaggactt aaaccgtata agctatagct gctcacatag ctttttgggg     4980

gctggcccct gccgtctcac cctcttactc aacctccctg cttttccttt ccattcccct     5040

tcttagccaa gatcttccct cttccttcaa agcttattcc tgggtcacca cctctaggaa     5100

gccctccctg actgctagtg gttggctcaa ctcccatgtt tgggtcctcc aaccctcatg     5160

ccctgcatgg ccaggatctg ctcttctgcc ttgtcctagg ctattgcaga gcagggatct     5220

ggcctgttta cttctagctt tgggatgccc agcgcgagcc agtccagagc caagactcag     5280

gaaatgcccg ctgatggcag cccggcagtc agcccctgtc cagacaacag ggcagtggga     5340

ggagtgggga ggacccgggt aggaggaatc tggttatctg gttcccacca gcctagcagc     5400

tttgccaagc aagagattag aggctaggtc ccctatgcct gtctccctgt ggggtttttt     5460

tttttttgac taagtctcac tctgttgccc aggctggagt gcagtggcgt gatcttggct     5520

cactgcaacc accatctcct gggttcagct gattctctgc cttagctgcc tgagtagctg     5580

ggattacagg cacctgccat cgtgcccggc tcatttttgt attttagcag agacgcggtt     5640

tcaccatgtt ggtcaggctg gtcttgaact cctgacctca ggtgatccgc ccgccttggc     5700

ctcccgaagt gctaggatta caggcgtgag ccaccacatc cggcctccct gagggttttg     5760

aagtggctgg cctgggccca gctctgaggt aggccctcag tggggtgtgg gtggggcaga     5820

aggaggagct gctgggaaca gaatgtgggg ggccccagtt ctttgcatag tccagcaaag     5880

ggccttatcc tctggaggga gaggaggtaa gaattctact gggcctgtaa ggaccaggga     5940

gacaggggtt gatggtaggc atgtgtctgt ggtgggggtg aggagggggt taggtgctct     6000

gtttggtggc cagagaatgt ggcagaagct ggggcttcac caggagagag ggctgagcga     6060

ctggaggagt cctgaattaa aagcctcctg tgcttaaacg gagtagggtc ccagttgtca     6120

ctctctgggc cttggtgttt gttctcagat ggtggtgggg aagggggctg ggccttgtgg     6180

acccggtgac cagccagccc acggtgacag agcccccggc gcccttgcct tcccgcagca     6240

tgtggtcctg tacccgctgg tggccaagag tctccgcaac atcgcggtgg gcaaggaccc     6300

cctggagggc cagcggcact gctgcggtgt tgcacagatg cgtgaacaca gctccctggg     6360

ccatgctgac ctggacgccc tgcagcagaa cccccagccc ctcatcttcc acatggagat     6420

gctgaaggtg aggggccacc gcgcctggtc tcaccaggcc cccactgccc agcctcaggg     6480

cggcgctggc ctgtccaccc aggggtggtg ggatccgcag gtggactgct gggggagcgg     6540

acagagacaa gaaaacctgt gcaggaccct tggcagtacc ctgggtctcc tttcctcctc     6600

cttcacatct caaatgtcac ctcctccagg aaaccggccc tgcccacccg gtctcctcat     6660

tctctgtctc gcagcagctc atttccttta tagcctctgc cgcaccttga agtcccttgg     6720

aattcatgga tttccttgtc catttaggga acctgccatg cagcatgatc tctgcgaggg     6780

cagggctttt caccgtcttg ttcactgttc tattcttagc acttggcaca gtgctgggca     6840

cacaggagat gtgacatcga tgtttgatgc tttttgagtg acaagtagct ctgctgctgg     6900

tgtgtgatgt ctgggggccc agccagccca gatgtgggtc aggtctgctg ctgacggacg     6960

cagctgtggt gtccccgagc cccgctgtga tatgccccat gccctgcagg tggagagccc     7020

tggcacgtac cagcaggacc catgggccat gacagacgaa gagaaggcaa aggcagtgcc     7080

acttatccac caggagggca accggttgta ccgcgagggg catgtgaagg aggctgctgc     7140

caagtactac gatgccattg cctgcctcaa gaacctgcag atgaaggtac tgcctggagg     7200

ctgaggggga ggatggatgg aggggggtgt ggagccaggg ggcccaggtc tacagcttct     7260

ccccgctccc tgcccccata ctcccaggaa cagcctgggt cccctgaatg gatccagctg     7320

gaccagcaga tcacgccgct gctgctcaac tactgccagt gcaagctggt ggtcgaggag     7380

tactacgagg tgctggacca ctgctcttcc atcctcaaca agtacgacgg tgagcaccgg     7440

gccctgggct gccgggggct gcgagtggtc agagagtggc ctttctcctg tcactgctgg     7500

ggtcaagacc tagcctttca caacccccat tctgagctcc cacgggggcc tgactaaatg     7560

cctctactcg gcagggctgt gggccccatt gtgccaatga agcatgaatg gtgtattggg     7620

ggtggggtgg catcctcagg tcagggaggg ctctctctcc cctgtgggcc catggtgcca     7680

ggagacatga gggcaggcag ctggccagga tcccccctca tgcccttgca tgcccactgc     7740

ccactggcct cccctgcaga caacgtcaag gcctacttca agcggggcaa ggcccacgcg     7800

gccgtgtgga atgcccagga ggcccaggct gactttgcca aagtgctgga gctggaccca     7860

gccctggcgc ctgtggtgag ccgagagctg caggccctgg aggcacggat ccggcagaag     7920

gacgaagagg acaaagcccg gttccggggg atcttctccc attgacagga gcacttggcc     7980

ctgccttacc tgccaagccc actgctgcag ctgccagccc ccctgcccgt gctgcgtcat     8040

gcttctgtgt atataaaggc ctttatttat ctctctctga                           8080


<210> 9
<211> 330
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Thr 
            20                  25                  30          


Lys Ala Thr Phe His Tyr Arg Thr Leu His Ser Asp Asp Glu Gly Thr 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Thr Ile Val Cys Thr Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys His Val Val 
                85                  90                  95      


Leu Tyr Pro Leu Val Ala Lys Ser Leu Arg Asn Ile Ala Val Gly Lys 
            100                 105                 110         


Asp Pro Leu Glu Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg 
        115                 120                 125             


Glu His Ser Ser Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn 
    130                 135                 140                 


Pro Gln Pro Leu Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro 
145                 150                 155                 160 


Gly Thr Tyr Gln Gln Asp Pro Trp Ala Met Thr Asp Glu Glu Lys Ala 
                165                 170                 175     


Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu 
            180                 185                 190         


Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys 
        195                 200                 205             


Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile 
    210                 215                 220                 


Gln Leu Asp Gln Gln Ile Thr Pro Leu Leu Leu Asn Tyr Cys Gln Cys 
225                 230                 235                 240 


Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser 
                245                 250                 255     


Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg Gly 
            260                 265                 270         


Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp Phe 
        275                 280                 285             


Ala Lys Val Leu Glu Leu Asp Pro Ala Leu Ala Pro Val Val Ser Arg 
    290                 295                 300                 


Glu Leu Gln Ala Leu Glu Ala Arg Ile Arg Gln Lys Asp Glu Glu Asp 
305                 310                 315                 320 


Lys Ala Arg Phe Arg Gly Ile Phe Ser His 
                325                 330 


<210> 10
<211> 12695
<212> DNA
<213> Homo sapiens

<400> 10
cgcgccgggg cctggtgctc ggtcggcggg tgctgccgct ttaagcgggg gcgggactgc       60

gcgcggccga gcggttgcga cgagggctcg gctgggggtc gccggggtcg cgggccgggc      120

ctgcaggagc cgggccgccg aggtcggggc tggttgaact catggacctg atacttttct      180

cttgagaagc aaaccagccc aaaagaaaaa tggcgtttgt tgcaacacag ggggccacgg      240

tggttgacca gaccactttg atgaaaaagt accttcagtt tgtggcagct ctcacagatg      300

tgaatacacc tgatgaaaca aagttgaaaa tgatgcaaga agttagtgaa aattttgaga      360

atgtcacgtc atctcctcag tattctacat tcctagaaca tatcatccct cgattcctta      420

catttctcca agatggagaa gttcagtttc ttcaggagaa accagcacag caactgcgga      480

agctcgtact tgaaataatt catagaatac caaccaacga acatcttcgt cctcacacaa      540

aaaatgtttt gtctgtgatg tttcgctttt tagagacgga aaatgaagaa aatgttctta      600

tttgtctaag aataattatt gagctacaca aacagttcag gccaccgatc acacaagaaa      660

ttcatcattt tctggatttt gtgaaacaga tttacaagga gcttccaaaa gtagtgaacc      720

gctactttga gaaccctcaa gtgatccccg agaacacagt gcctccccca gaaatggttg      780

gtatgataac aacgattgct gtgaaagtca acccggagcg tgaggacagt gagactcgaa      840

cacattccat cattccgagg ggatcacttt ctctgaaagt gttggcagaa ttgcccatta      900

ttgttgtttt aatgtatcag ctctacaaac tgaacatcca caatgttgtt gctgagtttg      960

tgcccttgat catgaacacc attgccattc aggtgtctgc acaagcgagg caacataagc     1020

tttacaacaa ggagttgtat gctgacttca ttgctgctca gattaaaaca ttgtcatttt     1080

tagcttacat tatcaggatt taccaggagt tggtgactaa gtattctcag cagatggtga     1140

aaggaatgct ccagttactt tcaaattgtc cagcagagac tgcacacctc agaaaggagc     1200

ttctgattgc tgccaaacac atcctcacca cagagctgag aaaccagttc attccttgca     1260

tggacaagct gtttgatgaa tccatactaa ttggctcagg atatactgcc agagagactc     1320

taaggcccct cgcctacagc acgctggccg acctcgtgca ccatgtccgc cagcacctgc     1380

ccctcagcga cctctccctc gccgtccagc tcttcgccaa gaacatcgac gatgagtccc     1440

tgcccagcag catccagacc atgtcctgca agctcctgct gaacctggtg gactgcatcc     1500

gttccaagag cgagcaggag agtggcaatg ggagagacgt cctgatgcgg atgctggagg     1560

ttttcgttct caaattccac acaattgctc ggtaccagct ctctgccatt tttaagaagt     1620

gtaagcctca gtcagaactt ggagccgtgg aagcagctct gcctggggtg cccactgccc     1680

ctgcagctcc tggccctgct ccctccccag cccctgtccc tgccccacct ccacccccgc     1740

ccccaccccc acctgccacc cctgtgaccc cggcccccgt gcctcccttc gagaagcaag     1800

gagaaaagga caaggaagac aagcagacat tccaagtcac agactgtcga agtttggtca     1860

aaaccttggt gtgtggtgtc aagacaatca cgtggggcat aacatcatgc aaagcacctg     1920

gtgaagctca gttcattccc aacaagcagt tacaacccaa agagacacag atttacatca     1980

aacttgtgaa atatgcaatg caagctttag atatttatca ggtccagata gcaggaaatg     2040

gacagacata catccgtgtg gccaactgcc agactgtgag aatgaaagag gagaaggagg     2100

tattggagca tttcgctggt gtgttcacaa tgatgaaccc cttaacgttc aaagaaatct     2160

tccaaactac ggtcccttat atggtggaga gaatctcaaa aaattatgct cttcagattg     2220

ttgccaattc cttcttggca aatcctacta cctctgctct gtttgctacg attctggtgg     2280

aatatctcct tgatcgcctg ccagaaatgg gctccaacgt ggagctctcc aacctgtacc     2340

tcaagctgtt caagctggtc tttggctctg tctccctctt tgcagctgaa aatgaacaaa     2400

tgctgaagcc tcacttgcac aagattgtga acagctctat ggagctcgcg cagactgcca     2460

aggaacccta caactacttc ttgctgctac gggcgctgtt tcgctctatt ggtggaggta     2520

gccacgatct cttgtatcag gagttcttgc ctctccttcc aaacctcctg caagggctga     2580

acatgcttca gagtggcctg cacaagcagc acatgaagga cctctttgtg gagctgtgtc     2640

tcaccgtccc tgtgcggctg agctcgcttt tgccgtacct gcccatgctt atggatccct     2700

tggtgtctgc actcaatggg tctcagacat tggtcagcca aggcctcagg acgctggagc     2760

tgtgtgtgga caacctgcag cccgacttcc tctacgacca catccagccg gtgcgcgcag     2820

agctcatgca ggctctgtgg cgcaccttac gcaaccctgc tgacagcatc tcccacgtgg     2880

cctaccgtgt gctcggtaag tttggcggca gtaacaggaa gatgctgaag gagtcgcaga     2940

agctgcacta cgttgtgacc gaggttcagg gccccagcat cactgtggag ttttccgact     3000

gcaaagcttc tctccagctc cccatggaga aggccattga aactgctctg gactgcctga     3060

aaagcgccaa cactgagccc tactaccgga ggcaggcgtg ggaagtgatc aaatgcttcc     3120

tggtggccat gatgagcctg gaggacaaca agcacgcact ctaccagctc ctggcacacc     3180

ccaactttac agaaaagacc atccccaatg ttatcatctc acatcgctac aaagcccagg     3240

acactccagc ccggaagact tttgagcagg ccctgacagg cgccttcatg tctgctgtca     3300

ttaaggacct gcggcccagc gccctgccct ttgtcgccag cttgatccgc cactatacga     3360

tggtggcagt cgcccagcag tgtggccctt tcttgctgcc ttgctaccag gtgggcagcc     3420

agcccagcac agccatgttt cacagtgaag aaaatggctc gaaaggaatg gatcctttgg     3480

ttctcattga tgcaattgct atttgtatgg catatgaaga aaaggagctt tgcaaaatcg     3540

gggaggtggc cctagctgtg atatttgatg ttgcaagtat catcctgggc tccaaggaga     3600

gggcctgcca gctgcccctg ttttcttaca tcgtggagcg cctgtgtgca tgttgttatg     3660

aacaggcgtg gtatgcaaag ctggggggtg tggtgtctat taagtttctc atggagcggc     3720

tgcctctcac ttgggttctc cagaaccagc agacattcct gaaagcactt ctctttgtca     3780

tgatggactt aactggagag gtttccaatg gggcagtcgc tatggcaaag accacgctgg     3840

agcagcttct gatgcggtgc gcaacgcctt taaaagacga ggagagagcc gaagagatcg     3900

tggccgccca ggaaaagtct ttccaccatg tgacacacga cttggttcga gaagtcacct     3960

ctccaaactc cactgtgagg aagcaggcca tgcattcgct gcaggtgttg gcccaggtca     4020

ctgggaagag tgtcacggtg atcatggaac cccacaaaga ggtcctgcag gatatggtcc     4080

cccctaagaa gcacctgctc cgacaccagc ctgccaacgc acagattggc ctgatggagg     4140

ggaacacgtt ctgtaccacg ttgcagccca ggctcttcac aatggacctt aacgtggtgg     4200

agcataaggt gttctacaca gagctgttga atttgtgtga ggctgaagat tcagctttaa     4260

caaagctgcc ctgttataaa agccttccgt cactcgtacc tttacgaatt gcggcattaa     4320

atgcacttgc tgcctgcaat taccttcctc agtccaggga gaaaatcatc gctgcactct     4380

tcaaagccct gaattccacc aatagtgagc tccaagaggc cggagaagcc tgtatgagaa     4440

agtttttaga aggtgctacc atagaagtcg atcaaatcca cacacatatg cgacctttgc     4500

tgatgatgct gggagattac cggagcttga cgctgaatgt tgtgaatcgc ctgacttcgg     4560

tcacgaggct cttcccaaat tccttcaatg ataaattttg tgatcagatg atgcaacatc     4620

tgcgcaagtg gatggaagtg gtggtgatca cccacaaagg gggccagagg agcgacggaa     4680

acgaaagcat ttccgagtgc gggagatgtc ccttgtctcc attctgtcag tttgaggaaa     4740

tgaagatttg ctcagcaatt ataaaccttt ttcatctgat cccggctgct cctcagacac     4800

tggtgaagcc tttgctagag gttgtcatga aaacggagcg ggcgatgctg atcgaggcgg     4860

ggagtccatt ccgagagccc ctgatcaagt tcctgactcg acatccctcg cagacagtgg     4920

agctgttcat gatggaagcc acactgaacg atccccagtg gagcagaatg tttatgagtt     4980

ttttaaaaca caaagacgcc agacctctgc gggatgtgct ggctgccaac cccaacaggt     5040

tcatcaccct gctgctgccg gggggtgccc agacggctgt gcgccccggt tcgcccagca     5100

ccagcaccat gcgcctggac ctccagttcc aggccatcaa gatcataagc attatagtga     5160

aaaacgatga ctcctggctg gccagccagc actctctggt gagccagttg cgacgtgtgt     5220

gggtgagtga gaacttccaa gagaggcacc gcaaggagaa catggcagcc accaactgga     5280

aggagcccaa gctgctggcc tactgcctgc tgaactactg caaaaggaat tacggagata     5340

tagaattgct gttccagctg ctccgagcct ttactggtcg ttttctctgc aacatgacat     5400

tcttaaaaga gtatatggag gaagagattc ccaaaaatta cagcatcgct cagaaacgtg     5460

ccctgttctt tcgctttgta gacttcaacg accccaactt cggagatgaa ttaaaagcta     5520

aagttctgca gcatatcttg aatcctgctt tcttgtacag ctttgagaag ggggaaggag     5580

agcagctctt gggacctccc aatccagaag gagataaccc agaaagcatc accagtgtgt     5640

ttattaccaa ggtcctggac cccgagaagc aggcggacat gctggactcg ctgcggatct     5700

acctgctgca gtacgccacg ctgctggtgg agcacgcccc ccaccacatc catgacaaca     5760

acaagaaccg caacagcaag ctgcgccgcc tcatgacctt cgcctggccc tgcctgctct     5820

ccaaggcctg cgtggaccca gcctgcaagt acagcggaca cttgctcctg gcgcacatta     5880

tcgccaaatt cgccatacac aagaagatcg tcctgcaggt ttttcatagt ctcctcaagg     5940

ctcacgcaat ggaagctcga gcgatcgtca gacaggcgat ggccattctg accccggcgg     6000

tgccggccag gatggaggac gggcaccaga tgctgaccca ctggacccgg aagatcattg     6060

tggaggaggg gcacaccgtc ccgcagctgg tccacattct gcacctgata gtgcaacact     6120

tcaaggtgta ctacccggta cggcaccact tggtgcagca catggtgagc gccatgcaga     6180

ggctgggctt cacgcccagt gtcaccatcg agcagaggcg gctggccgtg gacctgtctg     6240

aagtcgtcat caagtgggag ctgcagagga tcaaggacca gcagccggat tcagatatgg     6300

acccaaattc cagtggagaa ggagtcaatt ctgtctcatc ctccattaag agaggcctgt     6360

ccgtggattc tgcccaggaa gtgaaacgct ttaggacggc caccggagcc atcagtgcag     6420

tctttgggag gagccagtcg ctacctggag cagactctct cctcgccaag cccattgaca     6480

agcagcacac agacactgtg gtgaacttcc ttatccgcgt ggcctgtcag gttaatgaca     6540

acaccaacac agcggggtcc cctggggagg tgctctctcg ccggtgtgtg aaccttctga     6600

agactgcgtt gcggccagac atgtggccca agtccgaact caagctgcag tggttcgaca     6660

agctgctgat gactgtggag cagccaaacc aagtgaacta tgggaatatc tgcacgggcc     6720

tagaagtgct gagcttcctg ctaactgtcc tccagtcccc agccatcctc agtagcttca     6780

aacctctgca gcgtggaatt gccgcctgca tgacatgtgg aaacaccaag gtgttgcgag     6840

ccgtccacag ccttctctcg cgcctgatga gcattttccc aacagagccg agtacttcca     6900

gtgtggcctc caaatatgaa gagctggagt gcctctacgc agccgtcgga aaggtcatct     6960

atgaagggct caccaactac gagaaggcca ccaatgccaa tccctcccag ctcttcggga     7020

cccttatgat cctcaagtct gcctgcagca acaaccccag ctacatagac aggctgatct     7080

ccgtctttat gcgctccctg cagaagatgg tccgggagca tttaaaccct caggcagcgt     7140

caggaagcac cgaagccacc tcaggtacaa gcgagctggt gatgctgagt ctggagctgg     7200

tgaagacgcg cctggcagtg atgagcatgg agatgcggaa gaacttcatc caggccatcc     7260

tgacatccct catcgaaaaa tcaccagatg ccaaaatcct ccgggctgtg gtcaaaatcg     7320

tggaagaatg ggtcaagaat aactccccaa tggcagccaa tcagacacct acactccggg     7380

agaagtccat tttgcttgtg aagatgatga cttacataga aaaacgcttt ccggaagacc     7440

ttgaattaaa tgcccagttt ttagatcttg ttaactatgt ctacagggat gagaccctct     7500

ctggcagcga gctgacggcg aaacttgagc ctgcctttct ctctgggctg cgctgtgccc     7560

agccactcat cagggcaaag tttttcgagg tttttgacaa ctccatgaaa cgtcgtgtct     7620

acgagcgctt gctctatgtg acctgttcgc agaactggga agccatgggg aaccacttct     7680

ggatcaagca gtgcattgag ctgcttctgg ccgtgtgtga gaagagcacc cccattggca     7740

ccagctgcca aggagccatg ctcccgtcca tcaccaacgt catcaacctg gccgatagcc     7800

acgaccgtgc cgccttcgcc atggtcacac atgtcaagca ggagccccgg gagcgggaga     7860

acagcgagtc caaagaggag gatgtagaga tagacatcga actagctcct ggggatcaga     7920

ccagcacgcc caaaaccaaa gaactttcag aaaaggacat tggaaaccag ctgcacatgc     7980

taaccaacag gcacgacaag tttctggaca ctctccgaga ggtgaagact ggagcgctgc     8040

tcagcgcttt cgttcagctg tgccacattt ccacgacgct ggcagagaag acgtgggtcc     8100

agcttttccc cagattgtgg aagatcctct ctgacagaca gcagcatgca ctcgcgggtg     8160

agataagtcc atttctgtgc agcggcagtc accaggtgca gcgggactgc cagcccagcg     8220

cgctgaactg ctttgtggaa gccatgtccc agtgcgtgcc gccaatcccc atccgaccct     8280

gcgtcctgaa gtacctgggg aagacacaca acctctggtt ccggtccacg ctgatgttgg     8340

agcaccaggc ttttgaaaag ggtctgagtc ttcagattaa gccgaagcaa acaacggagt     8400

tttatgagca ggagagcatc accccgccgc agcaggagat actggattcc cttgcggagc     8460

tttactccct gttacaagag gaagatatgt gggctggtct gtggcagaag cggtgcaagt     8520

actcggagac agcgactgcg attgcttacg agcagcacgg gttctttgag caggcacaag     8580

aatcctatga aaaggcaatg gataaagcca aaaaagaaca tgagaggagt aacgcctccc     8640

ctgctatttt ccctgaatac cagctctggg aagaccactg gattcgatgc tccaaggaat     8700

tgaaccagtg ggaagccctg acggagtacg gtcagtccaa aggccacatc aacccctacc     8760

tcgtcctgga gtgcgcctgg cgggtgtcca actggactgc catgaaggag gcgctggtgc     8820

aggtggaagt gagctgtccg aaggagatgg cctggaaggt gaacatgtac cgcggatacc     8880

tggccatctg ccaccccgag gagcagcagc tcagcttcat cgagcgcctg gtggagatgg     8940

ccagcagcct ggccatccgc gagtggcggc ggctgcccca cgtagtgtcc cacgtgcaca     9000

cgcctctcct acaggcagcc cagcaaatca tcgaactcca ggaagctgca caaatcaacg     9060

caggcttaca gccaaccaac ctgggaagga acaacagcct gcacgacatg aagacggtgg     9120

tgaagacctg gaggaaccga ctgcccatcg tgtctgacga cttgtcccac tggagcagca     9180

tcttcatgtg gaggcagcat cattaccagg gtaaaccgac ctggtccggc atgcattcat     9240

catcgattgt aactgcctat gagaatagct ctcagcatga tcccagttca aataacgcta     9300

tgcttggggt tcatgcatca gcttcagcga tcatccagta tggaaaaatc gcccggaaac     9360

aaggactggt caatgtagct ctggatatat taagtcggat tcatactatt ccaactgttc     9420

ctatcgtgga ttgcttccag aagattcgac agcaagttaa atgctacctc cagctggcag     9480

gcgtcatggg caaaaacgag tgcatgcagg gccttgaagt tattgaatct acaaatttaa     9540

aatacttcac aaaagagatg acagccgaat tttatgcact gaagggaatg ttcttggctc     9600

agatcaacaa gtccgaggag gcaaacaaag ccttctctgc agctgtgcag atgcacgatg     9660

tgctggtgaa agcctgggcc atgtggggcg actacctgga gaacatcttt gtgaaggagc     9720

ggcagctgca cctgggcgtg tctgccatca cctgctacct gcacgcctgc cggcatcaga     9780

acgagagcaa atcgaggaaa tacttagcca aggtgctgtg gcttttgagt tttgatgatg     9840

acaaaaacac tttggcagat gccgtcgaca agtactgcat tggtgtgcca cccatccagt     9900

ggctggcctg gatcccacag ctgctcacct gcctggttgg ctcggaggga aagctgctct     9960

tgaacctcat tagccaggtt ggacgcgtgt atccccaagc ggtctacttt cccatccgga    10020

ccctgtacct gaccctgaaa atagaacagc gggaacgcta caagagcgat ccagggccca    10080

taagagcaac agcacccatg tggcgctgca gccgaatcat gcacatgcag cgagagctcc    10140

accccaccct tctgtcttcc ctggaaggca tcgtcgatca gatggtctgg ttcagagaaa    10200

attggcatga agaggttctc aggcagctcc aacagggcct ggcgaaatgt tactccgtgg    10260

cgtttgagaa aagtggagcg gtgtccgatg ctaaaatcac cccccacact ctcaattttg    10320

tgaagaagtt ggtgagcacg tttggggtgg gcctggagaa tgtgtccaac gtctcgacca    10380

tgttctccag cgcagcctct gagtctctgg cccggcgggc gcaggccact gcacaagacc    10440

ctgtctttca gaagctgaaa ggccagttca cgacggattt tgacttcagc gttccaggat    10500

ccatgaagct tcataatctt atttctaagt tgaaaaagtg gatcaaaatc ttggaggcca    10560

agaccaagca actccccaaa ttcttcctca tagaggaaaa gtgccggttc ttgagcaatt    10620

tctcggcaca gacagctgaa gtggaaattc ctggggagtt tctgatgcca aagccaacgc    10680

attattacat caagattgca cggttcatgc cccgggtaga gattgtgcag aagcacaaca    10740

ccgcagcccg gcggctgtac atccggggac acaatggcaa gatctaccca tacctcgtca    10800

tgaacgacgc ctgcctcaca gagtcacggc gagaggagcg tgtgttgcag ctgctgcgtc    10860

tgctgaaccc ctgtttggag aagagaaagg agaccaccaa gaggcacttg tttttcacag    10920

tgccccgggt tgtggcagtt tccccacaga tgcgcctcgt ggaggacaac ccctcttcac    10980

tttcccttgt ggagatctac aagcagcgct gcgccaagaa gggcatcgag catgacaacc    11040

ccatctcccg ttactatgac cggctggcta cggtgcaggc gcggggaacc caagccagcc    11100

accaggtcct ccgcgacatc ctcaaggagg ttcagagtaa catggtgccg cgcagcatgc    11160

tcaaggagtg ggcgctgcac accttcccca atgccacgga ctactggacg ttccggaaga    11220

tgttcaccat ccagctggct ctgataggct tcgcggaatt cgtcctgcat ttaaatagac    11280

tcaaccccga gatgttacag atcgctcagg acactggcaa actgaatgtt gcctactttc    11340

gatttgacat aaacgacgcg actggagacc tggatgccaa ccgtcctgtc ccatttcgac    11400

tcacgcccaa catttctgag tttctgacca ccatcggggt ctccggcccg ttgacagcgt    11460

ccatgattgc ggtcgcccgg tgcttcgccc agccaaactt taaggtggat ggcattctga    11520

aaacggttct ccgggacgag atcattgctt ggcacaaaaa aacacaagag gacacgtcct    11580

ctcctctctc ggccgccggg cagccagaga acatggacag ccagcaactg gtgtccctgg    11640

ttcagaaagc cgtcaccgcc atcatgaccc gcctgcacaa cctcgcccag ttcgaaggcg    11700

gggaaagcaa ggtgaacacc ctggtggccg cggcaaacag cctggacaat ctgtgccgca    11760

tggaccccgc ctggcacccc tggctgtgac tgtggccgcc acggccaccc ggaatgtgaa    11820

gggcgctccg ggctctgagc ccgcagcttt tacgacttct ccctgcctcg ttccttatat    11880

tcacagaagc cccatagttt cactgggttg cggttatttt cctggtagtt tgcgtgtaag    11940

aaagggagaa tatagtttta gaggaagctg aactatgacg atgctgggcg aagcggttgg    12000

aaatggcaga gctgaaactt attccaagct ttcaaaataa tcttttaaga agccaggatt    12060

ctccggtctg gaatttctga gtgagtcctt tttttatggt gtcctccctc tgtgaatgta    12120

caggcggaac tgtacgaaca gctcccttcc atccattttt aactctttcg gaaataacac    12180

ctcacagcag cttcgtgctt ttgtacagac ctttgtaaca agtgtacaga aaactcattt    12240

tgtttgagaa acaggagttg atgaacccat catgctggtt tttctctgag cacaaagttt    12300

taggctgtac acagccagcc ttgggaatct cgttgagcgt tcggcgtgga tccacggggc    12360

caggccaccc tgcgggagcg ccacacgcat ccacttcgga ttcagtgggt gaagacagaa    12420

ctctgagagt ctgcaggcgg ctcctgtgct ttttatttct ggctcttcgg atgtcttcta    12480

gacatttact atcactgcac ctgaagaaaa aatcactttt accttcctaa tttaaaaaga    12540

caaaacagaa atgtacgttc cttcgctagc tttagtcttt ctgttcccat ttttataaat    12600

ctgagcattg ataatgttct atctaaattt gtacagtgtg attttttttt ttagaataaa    12660

tattttataa aagggttaaa aaaaaaaaaa aaaaa                               12695


<210> 11
<211> 3858
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr 
1               5                   10                  15      


Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn 
            20                  25                  30          


Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn 
        35                  40                  45              


Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His 
    50                  55                  60                  


Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile 
                85                  90                  95      


Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn 
            100                 105                 110         


Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn 
        115                 120                 125             


Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg 
    130                 135                 140                 


Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln 
145                 150                 155                 160 


Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro 
                165                 170                 175     


Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met 
            180                 185                 190         


Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu 
        195                 200                 205             


Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val 
    210                 215                 220                 


Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys 
225                 230                 235                 240 


Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn 
                245                 250                 255     


Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr 
            260                 265                 270         


Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu 
        275                 280                 285             


Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys 
    290                 295                 300                 


Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys 
305                 310                 315                 320 


Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys 
                325                 330                 335     


His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp 
            340                 345                 350         


Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg 
        355                 360                 365             


Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His 
    370                 375                 380                 


His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln 
385                 390                 395                 400 


Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln 
                405                 410                 415     


Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser 
            420                 425                 430         


Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met 
        435                 440                 445             


Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu 
    450                 455                 460                 


Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val 
465                 470                 475                 480 


Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro 
                485                 490                 495     


Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu 
        515                 520                 525             


Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr 
    530                 535                 540                 


Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile 
545                 550                 555                 560 


Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile 
                565                 570                 575     


Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu 
            580                 585                 590         


Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala 
        595                 600                 605             


Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg 
    610                 615                 620                 


Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr 
625                 630                 635                 640 


Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro 
                645                 650                 655     


Tyr Met Val Glu Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala 
            660                 665                 670         


Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile 
        675                 680                 685             


Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val 
    690                 695                 700                 


Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser 
705                 710                 715                 720 


Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu 
                725                 730                 735     


His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu 
            740                 745                 750         


Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly 
        755                 760                 765             


Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro 
    770                 775                 780                 


Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln 
785                 790                 795                 800 


His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg 
                805                 810                 815     


Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val 
            820                 825                 830         


Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr 
        835                 840                 845             


Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His 
    850                 855                 860                 


Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu 
865                 870                 875                 880 


Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly 
                885                 890                 895     


Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu 
            900                 905                 910         


His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe 
        915                 920                 925             


Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu 
    930                 935                 940                 


Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg 
945                 950                 955                 960 


Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser 
                965                 970                 975     


Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn 
            980                 985                 990         


Phe Thr Glu Lys Thr Ile Pro Asn  Val Ile Ile Ser His  Arg Tyr Lys 
        995                 1000                 1005             


Ala Gln  Asp Thr Pro Ala Arg  Lys Thr Phe Glu Gln  Ala Leu Thr 
    1010                 1015                 1020             


Gly Ala  Phe Met Ser Ala Val  Ile Lys Asp Leu Arg  Pro Ser Ala 
    1025                 1030                 1035             


Leu Pro  Phe Val Ala Ser Leu  Ile Arg His Tyr Thr  Met Val Ala 
    1040                 1045                 1050             


Val Ala  Gln Gln Cys Gly Pro  Phe Leu Leu Pro Cys  Tyr Gln Val 
    1055                 1060                 1065             


Gly Ser  Gln Pro Ser Thr Ala  Met Phe His Ser Glu  Glu Asn Gly 
    1070                 1075                 1080             


Ser Lys  Gly Met Asp Pro Leu  Val Leu Ile Asp Ala  Ile Ala Ile 
    1085                 1090                 1095             


Cys Met  Ala Tyr Glu Glu Lys  Glu Leu Cys Lys Ile  Gly Glu Val 
    1100                 1105                 1110             


Ala Leu  Ala Val Ile Phe Asp  Val Ala Ser Ile Ile  Leu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Arg Ala Cys Gln Leu  Pro Leu Phe Ser Tyr  Ile Val Glu 
    1130                 1135                 1140             


Arg Leu  Cys Ala Cys Cys Tyr  Glu Gln Ala Trp Tyr  Ala Lys Leu 
    1145                 1150                 1155             


Gly Gly  Val Val Ser Ile Lys  Phe Leu Met Glu Arg  Leu Pro Leu 
    1160                 1165                 1170             


Thr Trp  Val Leu Gln Asn Gln  Gln Thr Phe Leu Lys  Ala Leu Leu 
    1175                 1180                 1185             


Phe Val  Met Met Asp Leu Thr  Gly Glu Val Ser Asn  Gly Ala Val 
    1190                 1195                 1200             


Ala Met  Ala Lys Thr Thr Leu  Glu Gln Leu Leu Met  Arg Cys Ala 
    1205                 1210                 1215             


Thr Pro  Leu Lys Asp Glu Glu  Arg Ala Glu Glu Ile  Val Ala Ala 
    1220                 1225                 1230             


Gln Glu  Lys Ser Phe His His  Val Thr His Asp Leu  Val Arg Glu 
    1235                 1240                 1245             


Val Thr  Ser Pro Asn Ser Thr  Val Arg Lys Gln Ala  Met His Ser 
    1250                 1255                 1260             


Leu Gln  Val Leu Ala Gln Val  Thr Gly Lys Ser Val  Thr Val Ile 
    1265                 1270                 1275             


Met Glu  Pro His Lys Glu Val  Leu Gln Asp Met Val  Pro Pro Lys 
    1280                 1285                 1290             


Lys His  Leu Leu Arg His Gln  Pro Ala Asn Ala Gln  Ile Gly Leu 
    1295                 1300                 1305             


Met Glu  Gly Asn Thr Phe Cys  Thr Thr Leu Gln Pro  Arg Leu Phe 
    1310                 1315                 1320             


Thr Met  Asp Leu Asn Val Val  Glu His Lys Val Phe  Tyr Thr Glu 
    1325                 1330                 1335             


Leu Leu  Asn Leu Cys Glu Ala  Glu Asp Ser Ala Leu  Thr Lys Leu 
    1340                 1345                 1350             


Pro Cys  Tyr Lys Ser Leu Pro  Ser Leu Val Pro Leu  Arg Ile Ala 
    1355                 1360                 1365             


Ala Leu  Asn Ala Leu Ala Ala  Cys Asn Tyr Leu Pro  Gln Ser Arg 
    1370                 1375                 1380             


Glu Lys  Ile Ile Ala Ala Leu  Phe Lys Ala Leu Asn  Ser Thr Asn 
    1385                 1390                 1395             


Ser Glu  Leu Gln Glu Ala Gly  Glu Ala Cys Met Arg  Lys Phe Leu 
    1400                 1405                 1410             


Glu Gly  Ala Thr Ile Glu Val  Asp Gln Ile His Thr  His Met Arg 
    1415                 1420                 1425             


Pro Leu  Leu Met Met Leu Gly  Asp Tyr Arg Ser Leu  Thr Leu Asn 
    1430                 1435                 1440             


Val Val  Asn Arg Leu Thr Ser  Val Thr Arg Leu Phe  Pro Asn Ser 
    1445                 1450                 1455             


Phe Asn  Asp Lys Phe Cys Asp  Gln Met Met Gln His  Leu Arg Lys 
    1460                 1465                 1470             


Trp Met  Glu Val Val Val Ile  Thr His Lys Gly Gly  Gln Arg Ser 
    1475                 1480                 1485             


Asp Gly  Asn Glu Ser Ile Ser  Glu Cys Gly Arg Cys  Pro Leu Ser 
    1490                 1495                 1500             


Pro Phe  Cys Gln Phe Glu Glu  Met Lys Ile Cys Ser  Ala Ile Ile 
    1505                 1510                 1515             


Asn Leu  Phe His Leu Ile Pro  Ala Ala Pro Gln Thr  Leu Val Lys 
    1520                 1525                 1530             


Pro Leu  Leu Glu Val Val Met  Lys Thr Glu Arg Ala  Met Leu Ile 
    1535                 1540                 1545             


Glu Ala  Gly Ser Pro Phe Arg  Glu Pro Leu Ile Lys  Phe Leu Thr 
    1550                 1555                 1560             


Arg His  Pro Ser Gln Thr Val  Glu Leu Phe Met Met  Glu Ala Thr 
    1565                 1570                 1575             


Leu Asn  Asp Pro Gln Trp Ser  Arg Met Phe Met Ser  Phe Leu Lys 
    1580                 1585                 1590             


His Lys  Asp Ala Arg Pro Leu  Arg Asp Val Leu Ala  Ala Asn Pro 
    1595                 1600                 1605             


Asn Arg  Phe Ile Thr Leu Leu  Leu Pro Gly Gly Ala  Gln Thr Ala 
    1610                 1615                 1620             


Val Arg  Pro Gly Ser Pro Ser  Thr Ser Thr Met Arg  Leu Asp Leu 
    1625                 1630                 1635             


Gln Phe  Gln Ala Ile Lys Ile  Ile Ser Ile Ile Val  Lys Asn Asp 
    1640                 1645                 1650             


Asp Ser  Trp Leu Ala Ser Gln  His Ser Leu Val Ser  Gln Leu Arg 
    1655                 1660                 1665             


Arg Val  Trp Val Ser Glu Asn  Phe Gln Glu Arg His  Arg Lys Glu 
    1670                 1675                 1680             


Asn Met  Ala Ala Thr Asn Trp  Lys Glu Pro Lys Leu  Leu Ala Tyr 
    1685                 1690                 1695             


Cys Leu  Leu Asn Tyr Cys Lys  Arg Asn Tyr Gly Asp  Ile Glu Leu 
    1700                 1705                 1710             


Leu Phe  Gln Leu Leu Arg Ala  Phe Thr Gly Arg Phe  Leu Cys Asn 
    1715                 1720                 1725             


Met Thr  Phe Leu Lys Glu Tyr  Met Glu Glu Glu Ile  Pro Lys Asn 
    1730                 1735                 1740             


Tyr Ser  Ile Ala Gln Lys Arg  Ala Leu Phe Phe Arg  Phe Val Asp 
    1745                 1750                 1755             


Phe Asn  Asp Pro Asn Phe Gly  Asp Glu Leu Lys Ala  Lys Val Leu 
    1760                 1765                 1770             


Gln His  Ile Leu Asn Pro Ala  Phe Leu Tyr Ser Phe  Glu Lys Gly 
    1775                 1780                 1785             


Glu Gly  Glu Gln Leu Leu Gly  Pro Pro Asn Pro Glu  Gly Asp Asn 
    1790                 1795                 1800             


Pro Glu  Ser Ile Thr Ser Val  Phe Ile Thr Lys Val  Leu Asp Pro 
    1805                 1810                 1815             


Glu Lys  Gln Ala Asp Met Leu  Asp Ser Leu Arg Ile  Tyr Leu Leu 
    1820                 1825                 1830             


Gln Tyr  Ala Thr Leu Leu Val  Glu His Ala Pro His  His Ile His 
    1835                 1840                 1845             


Asp Asn  Asn Lys Asn Arg Asn  Ser Lys Leu Arg Arg  Leu Met Thr 
    1850                 1855                 1860             


Phe Ala  Trp Pro Cys Leu Leu  Ser Lys Ala Cys Val  Asp Pro Ala 
    1865                 1870                 1875             


Cys Lys  Tyr Ser Gly His Leu  Leu Leu Ala His Ile  Ile Ala Lys 
    1880                 1885                 1890             


Phe Ala  Ile His Lys Lys Ile  Val Leu Gln Val Phe  His Ser Leu 
    1895                 1900                 1905             


Leu Lys  Ala His Ala Met Glu  Ala Arg Ala Ile Val  Arg Gln Ala 
    1910                 1915                 1920             


Met Ala  Ile Leu Thr Pro Ala  Val Pro Ala Arg Met  Glu Asp Gly 
    1925                 1930                 1935             


His Gln  Met Leu Thr His Trp  Thr Arg Lys Ile Ile  Val Glu Glu 
    1940                 1945                 1950             


Gly His  Thr Val Pro Gln Leu  Val His Ile Leu His  Leu Ile Val 
    1955                 1960                 1965             


Gln His  Phe Lys Val Tyr Tyr  Pro Val Arg His His  Leu Val Gln 
    1970                 1975                 1980             


His Met  Val Ser Ala Met Gln  Arg Leu Gly Phe Thr  Pro Ser Val 
    1985                 1990                 1995             


Thr Ile  Glu Gln Arg Arg Leu  Ala Val Asp Leu Ser  Glu Val Val 
    2000                 2005                 2010             


Ile Lys  Trp Glu Leu Gln Arg  Ile Lys Asp Gln Gln  Pro Asp Ser 
    2015                 2020                 2025             


Asp Met  Asp Pro Asn Ser Ser  Gly Glu Gly Val Asn  Ser Val Ser 
    2030                 2035                 2040             


Ser Ser  Ile Lys Arg Gly Leu  Ser Val Asp Ser Ala  Gln Glu Val 
    2045                 2050                 2055             


Lys Arg  Phe Arg Thr Ala Thr  Gly Ala Ile Ser Ala  Val Phe Gly 
    2060                 2065                 2070             


Arg Ser  Gln Ser Leu Pro Gly  Ala Asp Ser Leu Leu  Ala Lys Pro 
    2075                 2080                 2085             


Ile Asp  Lys Gln His Thr Asp  Thr Val Val Asn Phe  Leu Ile Arg 
    2090                 2095                 2100             


Val Ala  Cys Gln Val Asn Asp  Asn Thr Asn Thr Ala  Gly Ser Pro 
    2105                 2110                 2115             


Gly Glu  Val Leu Ser Arg Arg  Cys Val Asn Leu Leu  Lys Thr Ala 
    2120                 2125                 2130             


Leu Arg  Pro Asp Met Trp Pro  Lys Ser Glu Leu Lys  Leu Gln Trp 
    2135                 2140                 2145             


Phe Asp  Lys Leu Leu Met Thr  Val Glu Gln Pro Asn  Gln Val Asn 
    2150                 2155                 2160             


Tyr Gly  Asn Ile Cys Thr Gly  Leu Glu Val Leu Ser  Phe Leu Leu 
    2165                 2170                 2175             


Thr Val  Leu Gln Ser Pro Ala  Ile Leu Ser Ser Phe  Lys Pro Leu 
    2180                 2185                 2190             


Gln Arg  Gly Ile Ala Ala Cys  Met Thr Cys Gly Asn  Thr Lys Val 
    2195                 2200                 2205             


Leu Arg  Ala Val His Ser Leu  Leu Ser Arg Leu Met  Ser Ile Phe 
    2210                 2215                 2220             


Pro Thr  Glu Pro Ser Thr Ser  Ser Val Ala Ser Lys  Tyr Glu Glu 
    2225                 2230                 2235             


Leu Glu  Cys Leu Tyr Ala Ala  Val Gly Lys Val Ile  Tyr Glu Gly 
    2240                 2245                 2250             


Leu Thr  Asn Tyr Glu Lys Ala  Thr Asn Ala Asn Pro  Ser Gln Leu 
    2255                 2260                 2265             


Phe Gly  Thr Leu Met Ile Leu  Lys Ser Ala Cys Ser  Asn Asn Pro 
    2270                 2275                 2280             


Ser Tyr  Ile Asp Arg Leu Ile  Ser Val Phe Met Arg  Ser Leu Gln 
    2285                 2290                 2295             


Lys Met  Val Arg Glu His Leu  Asn Pro Gln Ala Ala  Ser Gly Ser 
    2300                 2305                 2310             


Thr Glu  Ala Thr Ser Gly Thr  Ser Glu Leu Val Met  Leu Ser Leu 
    2315                 2320                 2325             


Glu Leu  Val Lys Thr Arg Leu  Ala Val Met Ser Met  Glu Met Arg 
    2330                 2335                 2340             


Lys Asn  Phe Ile Gln Ala Ile  Leu Thr Ser Leu Ile  Glu Lys Ser 
    2345                 2350                 2355             


Pro Asp  Ala Lys Ile Leu Arg  Ala Val Val Lys Ile  Val Glu Glu 
    2360                 2365                 2370             


Trp Val  Lys Asn Asn Ser Pro  Met Ala Ala Asn Gln  Thr Pro Thr 
    2375                 2380                 2385             


Leu Arg  Glu Lys Ser Ile Leu  Leu Val Lys Met Met  Thr Tyr Ile 
    2390                 2395                 2400             


Glu Lys  Arg Phe Pro Glu Asp  Leu Glu Leu Asn Ala  Gln Phe Leu 
    2405                 2410                 2415             


Asp Leu  Val Asn Tyr Val Tyr  Arg Asp Glu Thr Leu  Ser Gly Ser 
    2420                 2425                 2430             


Glu Leu  Thr Ala Lys Leu Glu  Pro Ala Phe Leu Ser  Gly Leu Arg 
    2435                 2440                 2445             


Cys Ala  Gln Pro Leu Ile Arg  Ala Lys Phe Phe Glu  Val Phe Asp 
    2450                 2455                 2460             


Asn Ser  Met Lys Arg Arg Val  Tyr Glu Arg Leu Leu  Tyr Val Thr 
    2465                 2470                 2475             


Cys Ser  Gln Asn Trp Glu Ala  Met Gly Asn His Phe  Trp Ile Lys 
    2480                 2485                 2490             


Gln Cys  Ile Glu Leu Leu Leu  Ala Val Cys Glu Lys  Ser Thr Pro 
    2495                 2500                 2505             


Ile Gly  Thr Ser Cys Gln Gly  Ala Met Leu Pro Ser  Ile Thr Asn 
    2510                 2515                 2520             


Val Ile  Asn Leu Ala Asp Ser  His Asp Arg Ala Ala  Phe Ala Met 
    2525                 2530                 2535             


Val Thr  His Val Lys Gln Glu  Pro Arg Glu Arg Glu  Asn Ser Glu 
    2540                 2545                 2550             


Ser Lys  Glu Glu Asp Val Glu  Ile Asp Ile Glu Leu  Ala Pro Gly 
    2555                 2560                 2565             


Asp Gln  Thr Ser Thr Pro Lys  Thr Lys Glu Leu Ser  Glu Lys Asp 
    2570                 2575                 2580             


Ile Gly  Asn Gln Leu His Met  Leu Thr Asn Arg His  Asp Lys Phe 
    2585                 2590                 2595             


Leu Asp  Thr Leu Arg Glu Val  Lys Thr Gly Ala Leu  Leu Ser Ala 
    2600                 2605                 2610             


Phe Val  Gln Leu Cys His Ile  Ser Thr Thr Leu Ala  Glu Lys Thr 
    2615                 2620                 2625             


Trp Val  Gln Leu Phe Pro Arg  Leu Trp Lys Ile Leu  Ser Asp Arg 
    2630                 2635                 2640             


Gln Gln  His Ala Leu Ala Gly  Glu Ile Ser Pro Phe  Leu Cys Ser 
    2645                 2650                 2655             


Gly Ser  His Gln Val Gln Arg  Asp Cys Gln Pro Ser  Ala Leu Asn 
    2660                 2665                 2670             


Cys Phe  Val Glu Ala Met Ser  Gln Cys Val Pro Pro  Ile Pro Ile 
    2675                 2680                 2685             


Arg Pro  Cys Val Leu Lys Tyr  Leu Gly Lys Thr His  Asn Leu Trp 
    2690                 2695                 2700             


Phe Arg  Ser Thr Leu Met Leu  Glu His Gln Ala Phe  Glu Lys Gly 
    2705                 2710                 2715             


Leu Ser  Leu Gln Ile Lys Pro  Lys Gln Thr Thr Glu  Phe Tyr Glu 
    2720                 2725                 2730             


Gln Glu  Ser Ile Thr Pro Pro  Gln Gln Glu Ile Leu  Asp Ser Leu 
    2735                 2740                 2745             


Ala Glu  Leu Tyr Ser Leu Leu  Gln Glu Glu Asp Met  Trp Ala Gly 
    2750                 2755                 2760             


Leu Trp  Gln Lys Arg Cys Lys  Tyr Ser Glu Thr Ala  Thr Ala Ile 
    2765                 2770                 2775             


Ala Tyr  Glu Gln His Gly Phe  Phe Glu Gln Ala Gln  Glu Ser Tyr 
    2780                 2785                 2790             


Glu Lys  Ala Met Asp Lys Ala  Lys Lys Glu His Glu  Arg Ser Asn 
    2795                 2800                 2805             


Ala Ser  Pro Ala Ile Phe Pro  Glu Tyr Gln Leu Trp  Glu Asp His 
    2810                 2815                 2820             


Trp Ile  Arg Cys Ser Lys Glu  Leu Asn Gln Trp Glu  Ala Leu Thr 
    2825                 2830                 2835             


Glu Tyr  Gly Gln Ser Lys Gly  His Ile Asn Pro Tyr  Leu Val Leu 
    2840                 2845                 2850             


Glu Cys  Ala Trp Arg Val Ser  Asn Trp Thr Ala Met  Lys Glu Ala 
    2855                 2860                 2865             


Leu Val  Gln Val Glu Val Ser  Cys Pro Lys Glu Met  Ala Trp Lys 
    2870                 2875                 2880             


Val Asn  Met Tyr Arg Gly Tyr  Leu Ala Ile Cys His  Pro Glu Glu 
    2885                 2890                 2895             


Gln Gln  Leu Ser Phe Ile Glu  Arg Leu Val Glu Met  Ala Ser Ser 
    2900                 2905                 2910             


Leu Ala  Ile Arg Glu Trp Arg  Arg Leu Pro His Val  Val Ser His 
    2915                 2920                 2925             


Val His  Thr Pro Leu Leu Gln  Ala Ala Gln Gln Ile  Ile Glu Leu 
    2930                 2935                 2940             


Gln Glu  Ala Ala Gln Ile Asn  Ala Gly Leu Gln Pro  Thr Asn Leu 
    2945                 2950                 2955             


Gly Arg  Asn Asn Ser Leu His  Asp Met Lys Thr Val  Val Lys Thr 
    2960                 2965                 2970             


Trp Arg  Asn Arg Leu Pro Ile  Val Ser Asp Asp Leu  Ser His Trp 
    2975                 2980                 2985             


Ser Ser  Ile Phe Met Trp Arg  Gln His His Tyr Gln  Gly Lys Pro 
    2990                 2995                 3000             


Thr Trp  Ser Gly Met His Ser  Ser Ser Ile Val Thr  Ala Tyr Glu 
    3005                 3010                 3015             


Asn Ser  Ser Gln His Asp Pro  Ser Ser Asn Asn Ala  Met Leu Gly 
    3020                 3025                 3030             


Val His  Ala Ser Ala Ser Ala  Ile Ile Gln Tyr Gly  Lys Ile Ala 
    3035                 3040                 3045             


Arg Lys  Gln Gly Leu Val Asn  Ala Leu Asp Ile Leu  Ser Arg Ile 
    3050                 3055                 3060             


His Thr  Ile Pro Thr Val Pro  Ile Val Asp Cys Phe  Gln Lys Ile 
    3065                 3070                 3075             


Arg Gln  Gln Val Lys Cys Tyr  Leu Gln Leu Ala Gly  Val Met Gly 
    3080                 3085                 3090             


Lys Asn  Glu Cys Met Gln Gly  Leu Glu Val Ile Glu  Ser Thr Asn 
    3095                 3100                 3105             


Leu Lys  Tyr Phe Thr Lys Glu  Met Thr Ala Glu Phe  Tyr Ala Leu 
    3110                 3115                 3120             


Lys Gly  Met Phe Leu Ala Gln  Ile Asn Lys Ser Glu  Glu Ala Asn 
    3125                 3130                 3135             


Lys Ala  Phe Ser Ala Ala Val  Gln Met His Asp Val  Leu Val Lys 
    3140                 3145                 3150             


Ala Trp  Ala Met Trp Gly Asp  Tyr Leu Glu Asn Ile  Phe Val Lys 
    3155                 3160                 3165             


Glu Arg  Gln Leu His Leu Gly  Val Ser Ala Ile Thr  Cys Tyr Leu 
    3170                 3175                 3180             


His Ala  Cys Arg His Gln Asn  Glu Ser Lys Ser Arg  Lys Tyr Leu 
    3185                 3190                 3195             


Ala Lys  Val Leu Trp Leu Leu  Ser Phe Asp Asp Asp  Lys Asn Thr 
    3200                 3205                 3210             


Leu Ala  Asp Ala Val Asp Lys  Tyr Cys Ile Gly Val  Pro Pro Ile 
    3215                 3220                 3225             


Gln Trp  Leu Ala Trp Ile Pro  Gln Leu Leu Thr Cys  Leu Val Gly 
    3230                 3235                 3240             


Ser Glu  Gly Lys Leu Leu Leu  Asn Leu Ile Ser Gln  Val Gly Arg 
    3245                 3250                 3255             


Val Tyr  Pro Gln Ala Val Tyr  Phe Pro Ile Arg Thr  Leu Tyr Leu 
    3260                 3265                 3270             


Thr Leu  Lys Ile Glu Gln Arg  Glu Arg Tyr Lys Ser  Asp Pro Gly 
    3275                 3280                 3285             


Pro Ile  Arg Ala Thr Ala Pro  Met Trp Arg Cys Ser  Arg Ile Met 
    3290                 3295                 3300             


His Met  Gln Arg Glu Leu His  Pro Thr Leu Leu Ser  Ser Leu Glu 
    3305                 3310                 3315             


Gly Ile  Val Asp Gln Met Val  Trp Phe Arg Glu Asn  Trp His Glu 
    3320                 3325                 3330             


Glu Val  Leu Arg Gln Leu Gln  Gln Gly Leu Ala Lys  Cys Tyr Ser 
    3335                 3340                 3345             


Val Ala  Phe Glu Lys Ser Gly  Ala Val Ser Asp Ala  Lys Ile Thr 
    3350                 3355                 3360             


Pro His  Thr Leu Asn Phe Val  Lys Lys Leu Val Ser  Thr Phe Gly 
    3365                 3370                 3375             


Val Gly  Leu Glu Asn Val Ser  Asn Val Ser Thr Met  Phe Ser Ser 
    3380                 3385                 3390             


Ala Ala  Ser Glu Ser Leu Ala  Arg Arg Ala Gln Ala  Thr Ala Gln 
    3395                 3400                 3405             


Asp Pro  Val Phe Gln Lys Leu  Lys Gly Gln Phe Thr  Thr Asp Phe 
    3410                 3415                 3420             


Asp Phe  Ser Val Pro Gly Ser  Met Lys Leu His Asn  Leu Ile Ser 
    3425                 3430                 3435             


Lys Leu  Lys Lys Trp Ile Lys  Ile Leu Glu Ala Lys  Thr Lys Gln 
    3440                 3445                 3450             


Leu Pro  Lys Phe Phe Leu Ile  Glu Glu Lys Cys Arg  Phe Leu Ser 
    3455                 3460                 3465             


Asn Phe  Ser Ala Gln Thr Ala  Glu Val Glu Ile Pro  Gly Glu Phe 
    3470                 3475                 3480             


Leu Met  Pro Lys Pro Thr His  Tyr Tyr Ile Lys Ile  Ala Arg Phe 
    3485                 3490                 3495             


Met Pro  Arg Val Glu Ile Val  Gln Lys His Asn Thr  Ala Ala Arg 
    3500                 3505                 3510             


Arg Leu  Tyr Ile Arg Gly His  Asn Gly Lys Ile Tyr  Pro Tyr Leu 
    3515                 3520                 3525             


Val Met  Asn Asp Ala Cys Leu  Thr Glu Ser Arg Arg  Glu Glu Arg 
    3530                 3535                 3540             


Val Leu  Gln Leu Leu Arg Leu  Leu Asn Pro Cys Leu  Glu Lys Arg 
    3545                 3550                 3555             


Lys Glu  Thr Thr Lys Arg His  Leu Phe Phe Thr Val  Pro Arg Val 
    3560                 3565                 3570             


Val Ala  Val Ser Pro Gln Met  Arg Leu Val Glu Asp  Asn Pro Ser 
    3575                 3580                 3585             


Ser Leu  Ser Leu Val Glu Ile  Tyr Lys Gln Arg Cys  Ala Lys Lys 
    3590                 3595                 3600             


Gly Ile  Glu His Asp Asn Pro  Ile Ser Arg Tyr Tyr  Asp Arg Leu 
    3605                 3610                 3615             


Ala Thr  Val Gln Ala Arg Gly  Thr Gln Ala Ser His  Gln Val Leu 
    3620                 3625                 3630             


Arg Asp  Ile Leu Lys Glu Val  Gln Ser Asn Met Val  Pro Arg Ser 
    3635                 3640                 3645             


Met Leu  Lys Glu Trp Ala Leu  His Thr Phe Pro Asn  Ala Thr Asp 
    3650                 3655                 3660             


Tyr Trp  Thr Phe Arg Lys Met  Phe Thr Ile Gln Leu  Ala Leu Ile 
    3665                 3670                 3675             


Gly Phe  Ala Glu Phe Val Leu  His Leu Asn Arg Leu  Asn Pro Glu 
    3680                 3685                 3690             


Met Leu  Gln Ile Ala Gln Asp  Thr Gly Lys Leu Asn  Val Ala Tyr 
    3695                 3700                 3705             


Phe Arg  Phe Asp Ile Asn Asp  Ala Thr Gly Asp Leu  Asp Ala Asn 
    3710                 3715                 3720             


Arg Pro  Val Pro Phe Arg Leu  Thr Pro Asn Ile Ser  Glu Phe Leu 
    3725                 3730                 3735             


Thr Thr  Ile Gly Val Ser Gly  Pro Leu Thr Ala Ser  Met Ile Ala 
    3740                 3745                 3750             


Val Ala  Arg Cys Phe Ala Gln  Pro Asn Phe Lys Val  Asp Gly Ile 
    3755                 3760                 3765             


Leu Lys  Thr Val Leu Arg Asp  Glu Ile Ile Ala Trp  His Lys Lys 
    3770                 3775                 3780             


Thr Gln  Glu Asp Thr Ser Ser  Pro Leu Ser Ala Ala  Gly Gln Pro 
    3785                 3790                 3795             


Glu Asn  Met Asp Ser Gln Gln  Leu Val Ser Leu Val  Gln Lys Ala 
    3800                 3805                 3810             


Val Thr  Ala Ile Met Thr Arg  Leu His Asn Leu Ala  Gln Phe Glu 
    3815                 3820                 3825             


Gly Gly  Glu Ser Lys Val Asn  Thr Leu Val Ala Ala  Ala Asn Ser 
    3830                 3835                 3840             


Leu Asp  Asn Leu Cys Arg Met  Asp Pro Ala Trp His  Pro Trp Leu 
    3845                 3850                 3855             


