                         SEQUENCE LISTING

<110>  NantKwest, Inc.
 
<120>  CHIMERIC ANTIGEN RECEPTOR-MODIFIED NK-92 CELLS

<130>  104077.0003PCT5

<150>  62/756395 and 62/756402
<151>  2018-11-06

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FceRIgamma Intracellular Domain peptide

<400>  1

Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
1               5                   10                  15      


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
            20                  25                  30          


Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40      


<210>  2
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FceRIgamma Intracellular Domain

<400>  2
ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac       60

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc      120

cag                                                                    123


<210>  3
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19CAR FceRIgamma

<400>  3

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            260                 265                 270         


Ala Ala Leu Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Phe Trp Val Leu Val Val Val 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr 
        355                 360                 365             


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
    370                 375                 380                 


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
385                 390                 395             


<210>  4
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19CAR scFv

<400>  4

Ala Ala Thr Gly Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr 
1               5                   10                  15      


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
            20                  25                  30          


Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln 
        35                  40                  45              


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg 
    50                  55                  60                  


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
65                  70                  75                  80  


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
                85                  90                  95      


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly 
            100                 105                 110         


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
    130                 135                 140                 


Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr 
145                 150                 155                 160 


Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
                165                 170                 175     


Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly 
            180                 185                 190         


Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile 
        195                 200                 205             


Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
    210                 215                 220                 


Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr 
225                 230                 235                 240 


Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  5
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19CAR FceRIgamma DNA

<400>  5
atggactgga tctggcggat cctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgctgctg ctctgttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtccg actgaagatc     1080

caggtccgaa aggccgccat caccagctac gagaagtctg atggcgtgta caccggcctg     1140

agcaccagaa accaggaaac ctacgagaca ctgaagcacg agaagccccc ccagtaa        1197


<210>  6
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 Hinge

<400>  6

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Phe Trp 
        35                  40                  45              


Val Leu Val Val Val Gly 
    50                  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane domain

<400>  7

Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
1               5                   10                  15      


Phe Trp Val Arg 
            20  


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 signaling domain

<400>  8

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB signaling domain

<400>  9

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  10

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  11
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD3 zeta (codon optimized):

<400>  11
gtgaagttta gcagatctgc cgacgcccct gcctaccagc agggacagaa tcagctgtac       60

aacgagctga acctgggcag acgggaagag tacgacgtgc tggataagag aagaggcaga      120

gatcccgaga tgggcggcaa gccccagaga agaaagaatc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagaga      240

agaagaggca agggccacga tggactgtac cagggactga gcacagccac caaggatacc      300

tacgatgccc tgcacatgca ggccctgcct ccaagataa                             339


<210>  12
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD3 zeta (non-codon optimized)

<400>  12
gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat       60

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      120

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  13
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19CAR CD3z (DNA sequence)

<400>  13
atggactgga tctggcggat cctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgctgctg ctctgttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtccg agtgaagttc     1080

agcagatccg ccgatgcccc tgcttaccag cagggccaga atcagctgta caacgagctg     1140

aacctgggca gacgggaaga gtacgacgtg ctggataaga gaagaggcag agatcccgag     1200

atgggcggca agccccagag aagaaagaat ccccaggaag gcctgtataa cgaactgcag     1260

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagag aagaagaggc     1320

aagggccacg atggactgta ccagggactg agcacagcca ccaaggatac ctacgatgcc     1380

ctgcacatgc aggccctgcc tccaagataa                                      1410


<210>  14
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19CAR CD28/CD3z (DNA sequence)

<400>  14
atggactgga tctggcggat cctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgctgctg ctctgttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtccg aagcaagcgg     1080

agcaggctgc tgcacagcga ctacatgaac atgaccccta gaaggcctgg ccccaccaga     1140

aagcactatc agccttacgc ccctcccaga gacttcgccg cctacagatc cagagtgaag     1200

ttcagcagat ctgccgacgc ccctgcttac cagcagggcc agaatcagct gtacaacgag     1260

ctgaacctgg gcagacggga agagtacgac gtgctggata agagaagagg cagagatccc     1320

gagatgggcg gcaagcccca gagaagaaag aatccccagg aaggcctgta taacgaactg     1380

cagaaagaca agatggccga ggcctacagc gagatcggca tgaagggcga gagaagaaga     1440

ggcaagggcc acgatggact gtaccaggga ctgagcacag ccaccaagga tacctacgat     1500

gccctgcaca tgcaggccct gcctccaaga taa                                  1533


<210>  15
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19CAR_4-1BB/CD3z (DNA sequence)

<400>  15
atggactgga tctggcggat cctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgctgctg ctctgttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtcaa gcggggcaga     1080

aagaagctgc tgtacatctt caagcagccc ttcatgaggc ccgtgcagac cacacaggaa     1140

gaggacggct gcagctgtag attccctgag gaagaagaag gcggctgcga gctgagagtg     1200

aagtttagca gatctgccga cgcccctgcc taccagcagg gacagaatca gctgtacaac     1260

gagctgaacc tgggcagacg ggaagagtac gacgtgctgg ataagagaag aggcagagat     1320

cccgagatgg gcggcaagcc ccagagaaga aagaatcccc aggaaggcct gtataacgaa     1380

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagagaaga     1440

agaggcaagg gccacgatgg actgtaccag ggactgagca cagccaccaa ggatacctac     1500

gatgccctgc acatgcaggc cctgcctcca agataa                               1536


<210>  16
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19CAR_CD28/4-1BB/CD3z (DNA sequence)

<400>  16
atggactgga tctggcggat cctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgctgctg ctctgttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtccg aagcaagcgg     1080

agcaggctgc tgcacagcga ctacatgaac atgaccccta gaaggcctgg ccccaccaga     1140

aagcactatc agccttacgc ccctcccaga gacttcgccg cctatagatc caagcggggc     1200

agaaagaagc tgctgtacat cttcaagcag cccttcatga ggcccgtgca gaccacacag     1260

gaagaggacg gctgcagctg tagattccct gaggaagaag aaggcggctg cgagctgaga     1320

gtgaagttta gcagatctgc cgacgcccct gcctaccagc agggacagaa tcagctgtac     1380

aacgagctga acctgggcag acgggaagag tacgacgtgc tggataagag aagaggcaga     1440

gatcccgaga tgggcggcaa gccccagaga agaaagaatc cccaggaagg cctgtataac     1500

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagaga     1560

agaagaggca agggccacga tggactgtac cagggactga gcacagccac caaggatacc     1620

tacgatgccc tgcacatgca ggccctgcct ccaagataa                            1659


<210>  17
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19CAR_4-1BB/CD3z/CD28 (DNA sequence)

<400>  17
atggactgga tctggcggat cctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgctgctg ctctgttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtcaa gcggggcaga     1080

aagaagctgc tgtacatctt caagcagccc ttcatgaggc ccgtgcagac cacacaggaa     1140

gaggacggct gcagctgtag attccctgag gaagaagaag gcggctgcga gctgagagtg     1200

aagtttagca gatctgccga cgcccctgcc taccagcagg gacagaatca gctgtacaac     1260

gagctgaacc tgggcagacg ggaagagtac gacgtgctgg ataagagaag aggcagagat     1320

cccgagatgg gcggcaagcc ccagagaaga aagaatcccc aggaaggcct gtataacgaa     1380

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagagaaga     1440

agaggcaagg gccacgatgg actgtaccag ggactgagca cagccaccaa ggatacctac     1500

gatgccctgc acatgcaggc cctgcctcca agaagaagca agagatctag actgctgcac     1560

agcgactaca tgaacatgac ccctagaagg cctggcccca ccagaaagca ctatcagcct     1620

tacgcccctc ccagagactt cgccgcctac agatcttga                            1659


<210>  18
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-Type IL-2 (amino acid sequence)

<400>  18

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  19
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2-ER (amino acid sequence)

<400>  19

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


<210>  20
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding the Low Affinity Immunoglobulin Gamma Fc 
       Region Receptor III-A

<400>  20
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagggt gctcgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcgacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaagg caggaagtat tttcatcata attctgactt ctacattcca      480

aaagccacac tcaaagacag cggctcctac ttctgcaggg ggctttttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctttc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattc gaagctcaac aagagactgg      720

aaggaccata aatttaaatg gagaaaggac cctcaagaca aatga                      765


<210>  21
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-CAR DNA sequence (murine)

<400>  21
cccgggaatt cgccaccatg gactggatct ggcggatcct gttcctcgtg ggagccgcca       60

caggcgccca ttctgcccag cccgccgaca tccagatgac ccagaccacc agcagcctga      120

gcgccagcct gggcgacaga gtgaccatca gctgccgggc cagccaggac atcagcaagt      180

acctgaactg gtatcagcag aaacccgacg gcaccgtgaa gctgctgatc taccacacca      240

gccggctgca cagcggcgtg cccagcagat tttctggcag cggcagcggc accgactaca      300

gcctgaccat ctccaacctg gaacaggaag atatcgctac ctacttctgt cagcaaggca      360

acaccctgcc ctacaccttc ggcggaggca ccaagctgga actgaagaga ggcggcggag      420

gctctggtgg aggcggatct gggggcggag gaagtggcgg gggaggatct gaagtgcagc      480

tgcagcagag cggccctggc ctggtggccc ctagccagag cctgtccgtg acctgtaccg      540

tgtccggcgt gtccctgccc gactacggcg tgtcctggat ccggcagccc cccagaaagg      600

gcctggaatg gctgggcgtg atctggggca gcgagacaac ctactacaac agcgccctga      660

agtcccggct gaccatcatc aaggacaaca gcaagagcca ggtgttcctg aagatgaaca      720

gcctgcagac cgacgacacc gccatctact actgcgccaa gcactactac tacggcggca      780

gctacgccat ggactactgg ggccagggca ccaccgtgac cgtgtccagc gccctgtcca      840

acagcatcat gtacttcagc cacttcgtgc ccgtgtttct gcccgccaag cccaccacca      900

cccctgcccc tagacctccc accccagccc caacaatcgc cagccagcct ctgtccctgc      960

ggcccgaagc tagcagacct gctgccggcg gagccgtgca caccagaggc ctggacccca     1020

agctgtgcta cctgctggac ggcatcctgt tcatctatgg cgtgatcctg accgccctgt     1080

tcctgagagt gaagttcagc agaagcgccg acgcccctgc ctaccagcag ggccagaacc     1140

agctgtacaa cgagctgaac ctgggcagac gggaagagta cgacgtgctg gacaagcgga     1200

gaggcaggga ccccgagatg ggcggcaagc ccagacggaa gaacccccag gaaggcctgt     1260

ataacgaact gcagaaagac aagatggccg aggcctacag cgagatcggc atgaagggcg     1320

agcggcggag gggcaagggc cacgatggac tgtaccaggg cctgagcacc gccaccaagg     1380

acacctacga cgccctgcac atgcaggccc tgccccccag atgacagcca gggcatttct     1440

ccctcgagcg gccgc                                                      1455


<210>  22
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-CAR amino acids sequence (murine)

<400>  22

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            260                 265                 270         


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
        275                 280                 285             


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    290                 295                 300                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
305                 310                 315                 320 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Pro Lys Leu 
                325                 330                 335     


Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr 
            340                 345                 350         


Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg 
465             


<210>  23
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CD19 scFv - DNA sequence

<400>  23
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tct                                   813


<210>  24
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 scFv - Protein sequence

<400>  24

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270     


<210>  25
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CD20 scFv - DNA sequence

<400>  25
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggcca tggcgcaagt aaaactccaa gaatctgggg cggagctggt gaaaccgggg      120

gcgtctgtga agatgagctg taaagcatca ggctacacct tcacctccta taatatgcac      180

tgggtgaaac aaacacccgg acagggcctc gaatggattg gtgccatcta tcctggaaat      240

ggtgatacct catataatca gaagtttaag ggcaaggcta cgcttactgc ggataaaagc      300

tcttccactg cttacatgca actgagcagt ctcacttcag aggactcagc cgattattat      360

tgtgcccgca gcaactacta tggtagttca tactggtttt tcgacgtttg ggggcaaggt      420

accaccgtca cggtttcttc tggtgggggc ggaagcgggg gtggaggatc tgggggcggt      480

ggttcagaca ttgaactcac ccagagccct actattctga gcgcgtctcc aggtgaaaaa      540

gttacgatga cgtgcagagc atcaagtagt gtgaattata tggattggta tcaaaagaag      600

ccaggctcat ccccaaaacc gtggatctat gcaactagca acctcgcgtc aggggtgcca      660

gcaaggtttt ccggaagtgg ttctggcaca tcttatagtc tcaccatttc ccgagtggag      720

gctgaggatg cggccactta ttactgccag caatggtcat tcaatccccc aacatttggt      780

ggcggaacaa aactcgaaat taaacgg                                          807


<210>  26
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 scFv - Protein sequence

<400>  26

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Met Ala Gln Val Lys Leu Gln Glu Ser 
            20                  25                  30          


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln 
    50                  55                  60                  


Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn 
65                  70                  75                  80  


Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly 
        115                 120                 125             


Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Thr Ile Leu Ser Ala Ser 
                165                 170                 175     


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn 
            180                 185                 190         


Tyr Met Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp 
        195                 200                 205             


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            260                 265                 


<210>  27
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CD33 scfV - DNA sequence:

<400>  27
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg acattcaaat gactcagtcc ccttccagct tgtcagcctc agtaggggac      120

cgggtcacga tcacctgtcg agcgtctgag tcagtggata actacgggat ttctttcatg      180

aactggttcc agcagaagcc cggcaaagct cctaagctcc ttatatatgc agcctcaaat      240

caggggagcg gtgttcctag tcgcttcagt ggaagcggta gcggtacgga ctttacgttg      300

acgataagta gccttcagcc agatgacttt gccacttatt attgtcagca gtctaaggaa      360

gttccttgga cgtttggcca aggaacgaag gtcgaaatca aagggggagg gggctcagga      420

gggggcggca gtggtggtgg aggctctcaa gtccaactcg tacagtctgg cgcggaggtt      480

aaaaagccgg gaagctccgt gaaagtatcc tgtaaggcaa gcggatacac ctttaccgat      540

tataacatgc actgggttag gcaggcgccc ggccaaggtc tggaatggat cggttatatt      600

tatccataca acggtggtac cggctataat cagaagttta agagtaaggc tactattaca      660

gcggatgagt caaccaatac tgcatacatg gagctctcct cactcaggag cgaagatacc      720

gcagtgtatt actgtgcccg agggagacca gccatggact actggggtca gggtaccctt      780

gtgacagtat ctagc                                                       795


<210>  28
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 scfV - Protein sequence

<400>  28

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser 
    210                 215                 220                 


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


<210>  29
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CSPG4 scfV - DNA sequence

<400>  29
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg atatcgagct cacccaatct ccaaaattca tgtccacatc agtaggagac      120

agggtcagcg tcacctgcaa ggccagtcag aatgtggata ctaatgtagc gtggtatcaa      180

caaaaaccag ggcaatctcc tgaaccactg cttttctcgg catcctaccg ttacactgga      240

gtccctgatc gcttcacagg cagtggatct gggacagatt tcactctcac catcagcaat      300

gtgcagtctg aagacttggc agagtatttc tgtcagcaat ataacagcta tcctctgacg      360

ttcggtggcg gcaccaagct ggaaatcaaa cgggctgccg cagaaggtgg aggcggttca      420

ggtggcggag gttccggcgg aggtggctct ggcggtggcg gatcggccat ggcccaggtg      480

aagctgcagc agtcaggagg gggcttggtg caacctggag gctccatgaa actctcctgt      540

gttgtctctg gattcacttt cagtaattac tggatgaact gggtccgcca gtctccagag      600

aaggggcttg agtggattgc agaaattaga ttgaaatcca ataattttgg aagatattat      660

gcggagtctg tgaaagggag gttcaccatc tcaagagatg attccaaaag tagtgcctac      720

ctgcaaatga tcaacctaag agctgaagat actggcattt attactgtac cagttatggt      780

aactacgttg ggcactattt tgaccactgg ggccaaggga ccacggtcac cgtatcgagt      840


<210>  30
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSPG4 scfV - Protein sequence

<400>  30

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Glu Leu Thr Gln Ser Pro Lys 
            20                  25                  30          


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Glu Pro Leu Leu Phe Ser Ala Ser Tyr Arg Tyr Thr Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
            100                 105                 110         


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Ala Ala Ala Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Met Ala Gln Val 
145                 150                 155                 160 


Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Met 
                165                 170                 175     


Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr Trp Met 
            180                 185                 190         


Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Ala Glu 
        195                 200                 205             


Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Ala Tyr 
225                 230                 235                 240 


Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys 
                245                 250                 255     


Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp Gly Gln 
            260                 265                 270         


Gly Thr Thr Val Thr Val Ser Ser 
        275                 280 


<210>  31
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized EGFR scFv - DNA sequence

<400>  31
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atattcttct tactcaatct cccgttattt tgtcagtatc cccaggtgag      120

cgagtcagct tctcttgtcg agcgtcacaa tccattggca ccaacataca ttggtaccaa      180

cagcgcacca acgggtctcc ccggctcttg attaagtacg catcagaaag tatttctggg      240

atacccagta ggttctcagg gagcgggagt ggcactgact ttaccctgtc cataaacagc      300

gttgagtctg aggacatcgc ggactactat tgtcagcaga acaacaattg gccgaccacg      360

tttggtgcgg gaacaaaact tgaactcaaa ggcggcggag gaagcggagg cggaggatct      420

gggggcggag gctctggcgg agggggatct caggtgcagc tcaaacagtc aggacctggc      480

ctcgttcagc caagccaatc actgagtata acgtgcacgg tgagcggctt tagcctgaca      540

aactatggtg tccactgggt ccgccaatct cctggaaaag gcttggagtg gctcggtgtt      600

atctggtccg gtggtaacac agactacaac acgccattca ccagtcgcct tagtattaac      660

aaggacaact ccaagtctca ggttttcttt aaaatgaact ctctgcagtc taatgatacc      720

gcaatttact actgtgcgag ggcactcacg tactatgact atgagttcgc gtattggggc      780

caagggactc tcgttactgt ctcagcg                                          807


<210>  32
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR scFv - Protein sequence

<400>  32

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Leu Leu Thr Gln Ser Pro Val 
            20                  25                  30          


Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn 
    50                  55                  60                  


Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 
        195                 200                 205             


Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 
                245                 250                 255     


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            260                 265                 


<210>  33
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized IGF1R scFv - DNA sequence

<400>  33
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atgttgtaat gacgcagtca cccctgtcac tcccggtcac acccggagaa      120

ccagcgtcaa ttagctgccg atctagccaa agtttgcttc attccaatgg ttacaattat      180

ctcgactggt acttgcagaa acccggccaa tcccctcagc tgctcatcta ccttgggtct      240

aatagggcat ctggggttcc cgataggttc tctggctccg ggagcggcac cgactttacg      300

ttgaaaatct ctagggttga ggcggaagac gtaggcgttt actattgcat gcaggggacc      360

cactggccgc tgaccttcgg ccagggcacc aaggttgaaa taaaaggcgg cggaggaagc      420

ggaggcggag gatctggggg cggaggctct ggcggagggg gatctcaggt acagctccag      480

gaatcaggac ccggtttggt taagccctcc gggacccttt ccctcacgtg tgcagtctca      540

ggtgggtcaa ttagttcttc caattggtgg tcttgggtgc ggcaaccacc tggtaaaggt      600

ctcgagtgga taggggaaat ttatcatagt ggctccacca attataaccc ctcactcaag      660

tccagggtta cgatatctgt ggacaaaagt aaaaaccaat tctccctcaa acttagtagt      720

gtaacagcgg cagacaccgc ggtgtactac tgcgcacggt ggacaggccg aactgatgcc      780

tttgacattt ggggacaggg aactatggtg actgtgtcat cc                         822


<210>  34
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R scFv -Protein sequence

<400>  34

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Val Val Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser 
65                  70                  75                  80  


Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Met Gln Gly Thr His Trp Pro Leu Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
145                 150                 155                 160 


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr 
                165                 170                 175     


Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp 
            180                 185                 190         


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr 
        195                 200                 205             


His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
    210                 215                 220                 


Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
225                 230                 235                 240 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Thr Gly 
                245                 250                 255     


Arg Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
            260                 265                 270         


Ser Ser 
        


<210>  35
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CD30 scFv - DNA sequence

<400>  35
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccaaat gactcaatct cctagttcac tgtcagcctc tgttggtgat      120

cgcgtgacca ttacctgcca agctagccag gatattagca actacttgaa ctggtatcag      180

cagaagcctg gcaaagcccc aaagctgttg atctacgatg taagtaactt ggaaactggc      240

gtcccaagcc gcttctctgg atctggttca ggcaccgact tcactttcac tatcagcagc      300

ctgcagcctg aagatatcgc aacctactat tgccagcagg ttgctaatgt tcctctgact      360

ttcggccaag gcaccaaggt ggagatcaag ggcggcggag gaagcggagg cggaggatct      420

gggggcggag gctctggcgg agggggatct gaagttcagc ttgtagaatc tggaggtgga      480

ttggttcaac ctggtggctc tcttcgcctg agttgtgcag cctctggttt tactttctct      540

agttactgga tgcattgggt tcgtcaggct cctgggaaag gcctggaatg ggtttcagct      600

attagttgga gtggagatag tacttactac gcagacagtg tgaaaggtcg cttcaccatc      660

agccgtgata attctaagaa cactttgtac ctgcaaatga actccttgcg cgcagaagac      720

acggctgtgt actattgtgc ccgtgatcgc tctgcgactt ggtattatct ggggcttggt      780

ttcgatgtat ggggacaagg taccctggta acggtttcta gc                         822


<210>  36
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD30 scFv - Protein sequence

<400>  36

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Val Ser Asn Leu Glu Thr Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Val Ala Asn Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Phe Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Trp Ser Gly Asp Ser Thr 
        195                 200                 205             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Ser Ala Thr Trp Tyr Tyr 
                245                 250                 255     


Leu Gly Leu Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser 
        


<210>  37
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized HER2/neu scFv - DNA sequence

<400>  37
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg acatccagat gacccagagc cccagcagcc tgagcgccag cgtgggcgac      120

agagtgacca tcacctgcag agccagccag gacgtgaaca ccgccgtggc ctggtaccag      180

cagaagcccg gcaaggcccc caagctgctg atctacagcg ccagcttcct gtacagcggc      240

gtgcccagca gattcagcgg cagcagaagc ggcaccgact tcaccctgac catcagcagc      300

ctgcagcccg aggacttcgc cacctactac tgccagcagc actacaccac cccccccacc      360

ttcggccagg gcaccaaggt ggagatcaag tcctcagggg gcgggggaag tggtgggggc      420

ggcagcggcg gagggggctc aggaggaggc ggatcaggcg gatcagaggt gcagctggtg      480

gagagcggcg gcggcctggt gcagcccggc ggcagcctga gactgagctg cgccgccagc      540

ggcttcaaca tcaaggacac ctacatccac tgggtgagac aggcccccgg caagggcctg      600

gagtgggtgg ccagaatcta ccccaccaac ggctacacca gatacgccga cagcgtgaag      660

ggcagattca ccatcagcgc cgacaccagc aagaacaccg cctacctgca gatgaacagc      720

ctgagagccg aggacaccgc cgtgtactac tgcagcagat ggggcggcga cggcttctac      780

gccatggact actggggcca gggcaccctg gtgaccgtga gcagc                      825


<210>  38
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2/neu scFv - Protein sequence

<400>  38

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
        195                 200                 205             


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
                245                 250                 255     


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser 
        275 


<210>  39
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized GD2 scFv - DNA sequence VL/VH

<400>  39
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgcca gcatcgtgat gacccagact cctaagttcc tgctggtgtc tgccggcgac      120

agagtgacca tcacctgtaa agccagccag agcgtgtcca acgacgtggc ctggtatcag      180

cagaagcctg gacagagccc caagctgctg atctacagcg ccagcaacag atacaccggc      240

gtgcccgata gattcaccgg ctctggctac ggcaccgact tcacctttac catcagcacc      300

gtgcaggccg aggatctggc cgtgtacttc tgccagcaag actacagctc tctcggcgga      360

ggcaccaagc tggaaatcaa aggcggcgga ggaagcggag gcggaggatc tgggggcgga      420

ggctctggcg gagggggatc tcaggtgcaa gtgaaagagt ctggccctgg actggtggcc      480

ccaagccagt ctctgagcat cacatgtacc gtgtccggct tcagcctgac caactatggc      540

gtgcactggg tccgacagcc tccaggcaaa ggactggaat ggctgggagt gatttgggct      600

ggcggcagca ccaactacaa cagcgccctg atgagccggc tgagcatctc caaggacaac      660

agcaagagcc aggtgttcct gaagatgaac agcctgcaga ccgacgacac cgccatgtac      720

tactgtgcta gcagaggcgg caactacggc tacgccctgg attattgggg ccagggcaca      780

agcgtgaccg tgtcatct                                                    798


<210>  40
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized GD2 scFv - DNA sequence VH/VL

<400>  40
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccc aggtgcaagt gaaagagtct ggccctggac tggtggcccc aagccagtct      120

ctgagcatca catgtaccgt gtccggcttc agcctgacca actatggcgt gcactgggtc      180

cgacagcctc caggcaaagg actggaatgg ctgggagtga tttgggctgg cggcagcacc      240

aactacaaca gcgccctgat gagccggctg agcatctcca aggacaacag caagagccag      300

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatgtacta ctgtgctagc      360

agaggcggca actacggcta cgccctggat tattggggcc agggcacaag cgtgaccgtg      420

tcatctggcg gcggaggaag cggaggcgga ggatctgggg gcggaggctc tggcggaggg      480

ggatctagca tcgtgatgac ccagactcct aagttcctgc tggtgtctgc cggcgacaga      540

gtgaccatca cctgtaaagc cagccagagc gtgtccaacg acgtggcctg gtatcagcag      600

aagcctggac agagccccaa gctgctgatc tacagcgcca gcaacagata caccggcgtg      660

cccgatagat tcaccggctc tggctacggc accgacttca cctttaccat cagcaccgtg      720

caggccgagg atctggccgt gtacttctgc cagcaagact acagctctct cggcggaggc      780

accaagctgg aaatcaaa                                                    798


<210>  41
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2 scFv - Protein sequence VL/VH

<400>  41

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Ser Ile Val Met Thr Gln Thr Pro Lys 
            20                  25                  30          


Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe 
                85                  90                  95      


Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Asp Tyr Ser Ser Leu Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Val Lys Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
                165                 170                 175     


Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser 
        195                 200                 205             


Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ser Arg Gly Gly Asn Tyr Gly Tyr Ala Leu Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265     


<210>  42
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2 scFv - Protein sequence VH/VL

<400>  42

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Gln Val Gln Val Lys Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        35                  40                  45              


Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Thr 
65                  70                  75                  80  


Asn Tyr Asn Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn 
                85                  90                  95      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly Asn Tyr Gly Tyr Ala 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser 
                165                 170                 175     


Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser 
            180                 185                 190         


Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser 
                245                 250                 255     


Leu Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265     


<210>  43
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High Affinity Variant Ig gamma FcRIII-A amino acid sequence

<400>  43

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  44
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  High Affinity Variant IgGamma FcRIII-A nucleic acid sequence

<400>  44
atgtggcagc tgctgctgcc tacagctctc ctgctgctgg tgtccgccgg catgagaacc       60

gaggatctgc ctaaggccgt ggtgttcctg gaaccccagt ggtacagagt gctggaaaag      120

gacagcgtga ccctgaagtg ccagggcgcc tacagccccg aggacaatag cacccagtgg      180

ttccacaacg agagcctgat cagcagccag gccagcagct acttcatcga cgccgccacc      240

gtggacgaca gcggcgagta tagatgccag accaacctga gcaccctgag cgaccccgtg      300

cagctggaag tgcacatcgg atggctgctg ctgcaggccc ccagatgggt gttcaaagaa      360

gaggacccca tccacctgag atgccactct tggaagaaca ccgccctgca caaagtgacc      420

tacctgcaga acggcaaggg cagaaagtac ttccaccaca acagcgactt ctacatcccc      480

aaggccaccc tgaaggactc cggctcctac ttctgcagag gcctcgtggg cagcaagaac      540

gtgtccagcg agacagtgaa catcaccatc acccagggcc tggccgtgtc taccatcagc      600

agctttttcc cacccggcta ccaggtgtcc ttctgcctcg tgatggtgct gctgttcgcc      660

gtggacaccg gcctgtactt cagcgtgaaa acaaacatca gaagcagcac ccgggactgg      720

aaggaccaca agttcaagtg gcggaaggac ccccaggaca agtga                      765


<210>  45
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 Hinge peptide (Human)

<400>  45

Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
1               5                   10                  15      


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            20                  25                  30          


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        35                  40                  45              


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    50                  55                  60      


<210>  46
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 Hinge DNA (Human)

<400>  46
ctgagcaaca gcatcatgta cttcagccac ttcgtgcctg tgttcctgcc tgccaagcct       60

acaacaacac cagcccctag acctccaacc cctgccccta caattgcctc tcagcctctg      120

tctctgaggc ccgaagcttg tagacctgct gctggcggag ctgtgcacac cagaggactg      180

gat                                                                    183


<210>  47
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human T-cell surface glycoprotein CD3 zeta

<400>  47

Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val 
1               5                   10                  15      


Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            20                  25                  30          


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        35                  40                  45              


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    50                  55                  60                  


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
65                  70                  75                  80  


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                85                  90                  95      


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            100                 105                 110         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        115                 120                 125             


Met Gln Ala Leu Pro Pro Arg 
    130                 135 


<210>  48
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized CD123 scFv DNA

<400>  48
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccc tgcccgtcct gacacagtcc gcaagtgtga gtggatcacc tggacaatca      120

attactatca gttgcacagg cacttcctca gacgtaggga ggtatgatta cgtgtcatgg      180

tatcaacagc atccaggcaa agctcctcag ctcatgattt atgatgtgtc caacagaccg      240

tccggagtat ctaatcgctt cagtggatct aaatccggta atactgcctc cctcaccata      300

tcagggctcc aggccgaaga tgaagcagac tactattgca gtagttacac tggttcaagt      360

acgctttacg tttttggcac ggggaccaag gtaacggtcc tgggccaacc caaaggcgga      420

ggagggtccg gtggcggtgg cagtggtgga gggggatcag aggtgcaatt ggttgagagc      480

ggtggtgggc tggttaaacc tggcgggtcc ctccgcttgt cttgtgccgc aagcgggttt      540

acctttagta atgcgtggat gagctgggtg cgacaagcac ccggaaaggg cctggagtgg      600

gtcggtagga ttaaaagcaa aacagatggt ggaacaaccg attatgcggc cccagtcaag      660

ggaaggttca ctatttcaag agacgattcc aagaacactc tttacctcca aatgaatagt      720

ttgaaaacag aggatacagc agtgtactat tgcacaacgg actacgactt ttggagcgga      780

tattactact gggggcaagg taccctggtc acagtttcat ca                         822


<210>  49
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 scFv Protein sequence

<400>  49

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Leu Pro Val Leu Thr Gln Ser Ala Ser 
            20                  25                  30          


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 
        35                  40                  45              


Ser Ser Asp Val Gly Arg Tyr Asp Tyr Val Ser Trp Tyr Gln Gln His 
    50                  55                  60                  


Pro Gly Lys Ala Pro Gln Leu Met Ile Tyr Asp Val Ser Asn Arg Pro 
65                  70                  75                  80  


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
                85                  90                  95      


Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
            100                 105                 110         


Cys Ser Ser Tyr Thr Gly Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly 
        115                 120                 125             


Thr Lys Val Thr Val Leu Gly Gln Pro Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Lys Ser Lys Thr 
        195                 200                 205             


Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr Asp Tyr Asp 
                245                 250                 255     


Phe Trp Ser Gly Tyr Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser 
        


<210>  50
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized PD-L1 scFv  DNA

<400>  50
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgcca acatccagat gacccagtct ccatcttctg tgtctgcatc tgtaggagac      120

agagtcacca tcacttgtcg ggcgagtcag gatattagcc gctggttagc ctggtatcag      180

cagaaaccag ggaaagcccc taaactcctg atctatgctg catccagttt gcaaagtggg      240

gtcccatcga ggttcagcgg cagtggatct gggacagatt tcgctctcac tatcagcagc      300

ctgcagcctg aagattttgc aacttactat tgtcaacagg ctgacagtcg tttctcgatc      360

accttcggcc aagggacacg actggagatt aaaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaggtgc agctggtgca gtctggggga      480

ggcttggtac agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc      540

agtagctata gcatgaactg ggtccgccag gctccaggga aggggctgga gtgggtttca      600

tacattagta gtagtagtag taccatacag tacgcagact ctgtgaaggg ccgattcacc      660

atctccagag acaatgccaa gaactcactg tatctgcaaa tgaacagcct gagagacgag      720

gacacggctg tgtattactg tgcgagaggg gactactact acggtatgga cgtctggggc      780

caagggacca cggtcaccgt gagctca                                          807


<210>  51
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 scFv Protein

<400>  51

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asn Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ala Asp Ser Arg Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr 
        195                 200                 205             


Ile Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Tyr Gly Met 
                245                 250                 255     


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 


<210>  52
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized B7-H4 scFv  DNA

<400>  52
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg aagttcagct tgtagaatct ggaggtggat tggttcaacc tggtggctct      120

cttcgcctga gttgtgcagc ctctggtttt actttcaata gttacgctat gcattgggtt      180

cgtcaggctc ctgggaaagg cctggaatgg gtttcagcta ttagtggtaa tggaggtagt      240

actcgttacg cagacagtgt gaaaggtcgc ttcaccatca gccgtgataa ttctaagaac      300

actttgtacc tgcaaatgaa ctccttgcgc gcagaagaca cggctgtgta ctattgtgcc      360

cgtgatcgct ttcggaaggt tcatggtttc gatgtatggg gacaaggtac cctggtaacg      420

gtttctagcg gaggtggtgg gagtggtgga ggcggctcgg gtggaggtgg ttcaggagga      480

ggcggagata tccaaatgac tcaatctcct agttcactgt cagcctctgt tggtgatcgc      540

gtgaccatta cctgccaagc tagccaggat attagcaact acttgaactg gtatcagcag      600

aagcctggca aagccccaaa gctgttgatc tacgatgcaa gtaacttgga aactggcgtc      660

ccaagccgct tctctggatc tggttcaggc accgacttca ctttcactat cagcagcctg      720

cagcctgaag atatcgcaac ctactattgc cagcaggatg ctacttttcc tttgactttc      780

ggccaaggca ccaaggtgga gatcaag                                          807


<210>  53
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-H4 scFv  Protein

<400>  53

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Asn Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser 
65                  70                  75                  80  


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Phe Arg Lys Val His 
        115                 120                 125             


Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                165                 170                 175     


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser 
            180                 185                 190         


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Thr Phe 
                245                 250                 255     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            260                 265                 


<210>  54
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized HIV-gp120 binding domain (CD4)  DNA

<400>  54
atgaaccggg gagtcccttt taggcacttg cttctggtgc tgcaactggc gctcctccca       60

gcagccactc agggaaagaa agtggtgctg ggcaaaaaag gggatacagt ggaactgacc      120

tgtacagctt cccagaagaa gagcatacaa ttccactgga aaaactccaa ccagataaag      180

attctgggaa atcagggctc cttcttaact aaaggtccat ccaagctgaa tgatcgcgct      240

gactcaagaa gaagcctttg ggaccaagga aactttcccc tgatcatcaa gaatcttaag      300

atagaagact cagatactta catctgtgaa gtggaggacc agaaggagga ggtgcaattg      360

ctagtgttcg gattgactgc caactctgac acccacctgc ttcaggggca gagcctgacc      420

ctgaccttgg agagcccccc tggtagtagc ccctcagtgc aatgtaggag tccaaggggt      480

aaaaacatac agggggggaa gaccctctcc gtgtctcagc tggagctcca ggatagtggc      540

acctggacat gcactgtctt gcagaaccag aagaaggtgg agttcaaaat agacatcgtg      600

gtgctagctt tccagaaggc ctccagcata gtctataaga aagaggggga acaggtggag      660

ttctccttcc cactcgcctt tacagttgaa aagctgacgg gcagtggcga gctgtggtgg      720

caggcggaga gggcttcctc ctccaagtct tggatcacct ttgacctgaa gaacaaggaa      780

gtgtctgtaa aacgggttac ccaggaccct aagctccaga tgggcaagaa gctcccgctc      840

cacctcaccc tgccccaggc cttgcctcag tatgctggct ctggaaacct caccctggcc      900

cttgaagcga aaacaggaaa gttgcatcag gaagtgaacc tggtggtgat gagagccact      960

cagctccaga aaaatttgac ctgtgaggtg tggggaccca cctcccctaa gctgatgctg     1020

agtttgaaac tggagaacaa ggaggcaaag gtctcgaagc gggagaaggc ggtgtgggtg     1080

ctgaaccctg aggcggggat gtggcagtgt ctgctgagtg actcgggaca ggtcctgctg     1140

gaatccaaca tcaaggttct gcccacatgg tccaccccgg tgcagcca                  1188


<210>  55
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIV-gp120 binding domain (CD4) Protein

<400>  55

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro 
385                 390                 395     


<210>  56
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized FAP scFv VL/VH DNA

<400>  56
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg acatcgtgat gacacagagc ccttctagcc tggccgtgtc cgtgggagag      120

aaagtgacca tgagctgcaa gagcagccag agcctgctgt actcccggaa ccagaagaac      180

tacctggcct ggttccagca gaagcccggc cagtctccta agctgctgat cttctgggcc      240

agcaccagag aaagcggcgt gcccgataga ttcaccggca gcggctttgg caccgacttc      300

aacctgacaa tcagcagcgt gcaggccgag gacctggctg tgtacgattg ccagcagtac      360

ttcagctacc ctctgacctt tggagccggc accaagctgg aactgagagg cggcggagga      420

agcggaggcg gaggatctgg gggcggaggc tctggcggag ggggatctca ggttcagctg      480

cagcagtctg gacctgagct ggttaagcct ggcgcctccg tgaagatgag ctgcaagacc      540

agccggtaca ccttcaccga gtacaccatc cactgggtcc gacagagcca cggcaagagc      600

ctggaatgga tcggcggcat caaccccaac aacggcatcc ccaactacaa ccagaagttc      660

aagggcagag ccacactgac cgtgggcaag tctagcagca ccgcctacat ggaactgcgg      720

agcctgacaa gcgaggacag cgccgtgtac ttctgcgcca gaagaagaat cgcctacggc      780

tacgatgagg gccacgccat ggattattgg ggccagggaa caagcgtgac cgtgtctagt      840


<210>  57
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized FAP scFv VH/VL DNA

<400>  57
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccc aggttcagct gcagcagtct ggacctgagc tggttaagcc tggcgcctcc      120

gtgaagatga gctgcaagac cagccggtac accttcaccg agtacaccat ccactgggtc      180

cgacagagcc acggcaagag cctggaatgg atcggcggca tcaaccccaa caacggcatc      240

cccaactaca accagaagtt caagggcaga gccacactga ccgtgggcaa gtctagcagc      300

accgcctaca tggaactgcg gagcctgaca agcgaggaca gcgccgtgta cttctgcgcc      360

agaagaagaa tcgcctacgg ctacgatgag ggccacgcca tggattattg gggccaggga      420

acaagcgtga ccgtgtctag tggcggcgga ggaagcggag gcggaggatc tgggggcgga      480

ggctctggcg gagggggatc tgacatcgtg atgacacaga gcccttctag cctggccgtg      540

tccgtgggag agaaagtgac catgagctgc aagagcagcc agagcctgct gtactcccgg      600

aaccagaaga actacctggc ctggttccag cagaagcccg gccagtctcc taagctgctg      660

atcttctggg ccagcaccag agaaagcggc gtgcccgata gattcaccgg cagcggcttt      720

ggcaccgact tcaacctgac aatcagcagc gtgcaggccg aggacctggc tgtgtacgat      780

tgccagcagt acttcagcta ccctctgacc tttggagccg gcaccaagct ggaactgaga      840


<210>  58
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP scFv  VL/VH protein

<400>  58

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Val Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
        35                  40                  45              


Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp 
    50                  55                  60                  


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Phe Trp Ala 
65                  70                  75                  80  


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Phe 
                85                  90                  95      


Gly Thr Asp Phe Asn Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
            100                 105                 110         


Ala Val Tyr Asp Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly 
        115                 120                 125             


Ala Gly Thr Lys Leu Glu Leu Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
                165                 170                 175     


Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp 
            180                 185                 190         


Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
        195                 200                 205             


Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Gly Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Arg 
                245                 250                 255     


Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Ser Val Thr Val Ser Ser 
        275                 280 


<210>  59
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP scFv  VH/VL protein

<400>  59

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
        35                  40                  45              


Arg Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ser His 
    50                  55                  60                  


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Ile 
65                  70                  75                  80  


Pro Asn Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Gly 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Arg Ile Ala Tyr Gly Tyr 
        115                 120                 125             


Asp Glu Gly His Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
                165                 170                 175     


Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
            180                 185                 190         


Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp 
        195                 200                 205             


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Phe Trp Ala 
    210                 215                 220                 


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Phe 
225                 230                 235                 240 


Gly Thr Asp Phe Asn Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
                245                 250                 255     


Ala Val Tyr Asp Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly 
            260                 265                 270         


Ala Gly Thr Lys Leu Glu Leu Arg 
        275                 280 


<210>  60
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  60
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg acatccagat gacccagagc cccagcagcc tgagcgccag cgtgggcgac      120

agagtgacca tcacctgcag agccagccag gacgtgaaca ccgccgtggc ctggtaccag      180

cagaagcccg gcaaggcccc caagctgctg atctacagcg ccagcttcct gtacagcggc      240

gtgcccagca gattcagcgg cagcagaagc ggcaccgact tcaccctgac catcagcagc      300

ctgcagcccg aggacttcgc cacctactac tgccagcagc actacaccac cccccccacc      360

ttcggccagg gcaccaaggt ggagatcaag tcctcagggg gcgggggaag tggtgggggc      420

ggcagcggcg gagggggctc aggaggaggc ggatcaggcg gatcagaggt gcagctggtg      480

gagagcggcg gcggcctggt gcagcccggc ggcagcctga gactgagctg cgccgccagc      540

ggcttcaaca tcaaggacac ctacatccac tgggtgagac aggcccccgg caagggcctg      600

gagtgggtgg ccagaatcta ccccaccaac ggctacacca gatacgccga cagcgtgaag      660

ggcagattca ccatcagcgc cgacaccagc aagaacaccg cctacctgca gatgaacagc      720

ctgagagccg aggacaccgc cgtgtactac tgcagcagat ggggcggcga cggcttctac      780

gccatggact actggggcca gggcaccctg gtgaccgtga gcagcgcggc cgcgctgagc      840

aacagcatca tgtacttcag ccacttcgtg cctgtgttcc tgcctgccaa gcctacaaca      900

acaccagccc ctagacctcc aacccctgcc cctacaattg cctctcagcc tctgtctctg      960

aggcccgaag cttgtagacc tgctgctggc ggagctgtgc acaccagagg actggatttc     1020

gcctgctttt gggtgctggt ggtcgtgggc ggagtgctgg cttgttattc tctgctggtc     1080

accgtggcct tcatcatctt ttgggtccga ctgaagatcc aggtccgaaa ggccgccatc     1140

accagctacg agaagtctga tggcgtgtac accggcctga gcaccagaaa ccaggaaacc     1200

tacgagacac tgaagcacga gaagcccccc cag                                  1233


<210>  61
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  61
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccaaat gactcaatct cctagttcac tgtcagcctc tgttggtgat      120

cgcgtgacca ttacctgcca agctagccag gatattagca actacttgaa ctggtatcag      180

cagaagcctg gcaaagcccc aaagctgttg atctacgatg taagtaactt ggaaactggc      240

gtcccaagcc gcttctctgg atctggttca ggcaccgact tcactttcac tatcagcagc      300

ctgcagcctg aagatatcgc aacctactat tgccagcagg ttgctaatgt tcctctgact      360

ttcggccaag gcaccaaggt ggagatcaag ggcggcggag gaagcggagg cggaggatct      420

gggggcggag gctctggcgg agggggatct gaagttcagc ttgtagaatc tggaggtgga      480

ttggttcaac ctggtggctc tcttcgcctg agttgtgcag cctctggttt tactttctct      540

agttactgga tgcattgggt tcgtcaggct cctgggaaag gcctggaatg ggtttcagct      600

attagttgga gtggagatag tacttactac gcagacagtg tgaaaggtcg cttcaccatc      660

agccgtgata attctaagaa cactttgtac ctgcaaatga actccttgcg cgcagaagac      720

acggctgtgt actattgtgc ccgtgatcgc tctgcgactt ggtattatct ggggcttggt      780

ttcgatgtat ggggacaagg taccctggta acggtttcta gcgcggccgc gctgagcaac      840

agcatcatgt acttcagcca cttcgtgcct gtgttcctgc ctgccaagcc tacaacaaca      900

ccagccccta gacctccaac ccctgcccct acaattgcct ctcagcctct gtctctgagg      960

cccgaagctt gtagacctgc tgctggcgga gctgtgcaca ccagaggact ggatttcgcc     1020

tgcttttggg tgctggtggt cgtgggcgga gtgctggctt gttattctct gctggtcacc     1080

gtggccttca tcatcttttg ggtccgactg aagatccagg tccgaaaggc cgccatcacc     1140

agctacgaga agtctgatgg cgtgtacacc ggcctgagca ccagaaacca ggaaacctac     1200

gagacactga agcacgagaa gcccccccag                                      1230


<210>  62
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  62
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atattcttct tactcaatct cccgttattt tgtcagtatc cccaggtgag      120

cgagtcagct tctcttgtcg agcgtcacaa tccattggca ccaacataca ttggtaccaa      180

cagcgcacca acgggtctcc ccggctcttg attaagtacg catcagaaag tatttctggg      240

atacccagta ggttctcagg gagcgggagt ggcactgact ttaccctgtc cataaacagc      300

gttgagtctg aggacatcgc ggactactat tgtcagcaga acaacaattg gccgaccacg      360

tttggtgcgg gaacaaaact tgaactcaaa ggcggcggag gaagcggagg cggaggatct      420

gggggcggag gctctggcgg agggggatct caggtgcagc tcaaacagtc aggacctggc      480

ctcgttcagc caagccaatc actgagtata acgtgcacgg tgagcggctt tagcctgaca      540

aactatggtg tccactgggt ccgccaatct cctggaaaag gcttggagtg gctcggtgtt      600

atctggtccg gtggtaacac agactacaac acgccattca ccagtcgcct tagtattaac      660

aaggacaact ccaagtctca ggttttcttt aaaatgaact ctctgcagtc taatgatacc      720

gcaatttact actgtgcgag ggcactcacg tactatgact atgagttcgc gtattggggc      780

caagggactc tcgttactgt ctcagcggcg gccgcgctga gcaacagcat catgtacttc      840

agccacttcg tgcctgtgtt cctgcctgcc aagcctacaa caacaccagc ccctagacct      900

ccaacccctg cccctacaat tgcctctcag cctctgtctc tgaggcccga agcttgtaga      960

cctgctgctg gcggagctgt gcacaccaga ggactggatt tcgcctgctt ttgggtgctg     1020

gtggtcgtgg gcggagtgct ggcttgttat tctctgctgg tcaccgtggc cttcatcatc     1080

ttttgggtcc gactgaagat ccaggtccga aaggccgcca tcaccagcta cgagaagtct     1140

gatggcgtgt acaccggcct gagcaccaga aaccaggaaa cctacgagac actgaagcac     1200

gagaagcccc cccag                                                      1215


<210>  63
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  63
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atgttgtaat gacgcagtca cccctgtcac tcccggtcac acccggagaa      120

ccagcgtcaa ttagctgccg atctagccaa agtttgcttc attccaatgg ttacaattat      180

ctcgactggt acttgcagaa acccggccaa tcccctcagc tgctcatcta ccttgggtct      240

aatagggcat ctggggttcc cgataggttc tctggctccg ggagcggcac cgactttacg      300

ttgaaaatct ctagggttga ggcggaagac gtaggcgttt actattgcat gcaggggacc      360

cactggccgc tgaccttcgg ccagggcacc aaggttgaaa taaaaggcgg cggaggaagc      420

ggaggcggag gatctggggg cggaggctct ggcggagggg gatctcaggt acagctccag      480

gaatcaggac ccggtttggt taagccctcc gggacccttt ccctcacgtg tgcagtctca      540

ggtgggtcaa ttagttcttc caattggtgg tcttgggtgc ggcaaccacc tggtaaaggt      600

ctcgagtgga taggggaaat ttatcatagt ggctccacca attataaccc ctcactcaag      660

tccagggtta cgatatctgt ggacaaaagt aaaaaccaat tctccctcaa acttagtagt      720

gtaacagcgg cagacaccgc ggtgtactac tgcgcacggt ggacaggccg aactgatgcc      780

tttgacattt ggggacaggg aactatggtg actgtgtcat ccgcggccgc gctgagcaac      840

agcatcatgt acttcagcca cttcgtgcct gtgttcctgc ctgccaagcc tacaacaaca      900

ccagccccta gacctccaac ccctgcccct acaattgcct ctcagcctct gtctctgagg      960

cccgaagctt gtagacctgc tgctggcgga gctgtgcaca ccagaggact ggatttcgcc     1020

tgcttttggg tgctggtggt cgtgggcgga gtgctggctt gttattctct gctggtcacc     1080

gtggccttca tcatcttttg ggtccgactg aagatccagg tccgaaaggc cgccatcacc     1140

agctacgaga agtctgatgg cgtgtacacc ggcctgagca ccagaaacca ggaaacctac     1200

gagacactga agcacgagaa gcccccccag                                      1230


<210>  64
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  64
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg acattcaaat gactcagtcc ccttccagct tgtcagcctc agtaggggac      120

cgggtcacga tcacctgtcg agcgtctgag tcagtggata actacgggat ttctttcatg      180

aactggttcc agcagaagcc cggcaaagct cctaagctcc ttatatatgc agcctcaaat      240

caggggagcg gtgttcctag tcgcttcagt ggaagcggta gcggtacgga ctttacgttg      300

acgataagta gccttcagcc agatgacttt gccacttatt attgtcagca gtctaaggaa      360

gttccttgga cgtttggcca aggaacgaag gtcgaaatca aagggggagg gggctcagga      420

gggggcggca gtggtggtgg aggctctcaa gtccaactcg tacagtctgg cgcggaggtt      480

aaaaagccgg gaagctccgt gaaagtatcc tgtaaggcaa gcggatacac ctttaccgat      540

tataacatgc actgggttag gcaggcgccc ggccaaggtc tggaatggat cggttatatt      600

tatccataca acggtggtac cggctataat cagaagttta agagtaaggc tactattaca      660

gcggatgagt caaccaatac tgcatacatg gagctctcct cactcaggag cgaagatacc      720

gcagtgtatt actgtgcccg agggagacca gccatggact actggggtca gggtaccctt      780

gtgacagtat ctagcgcggc cgcgctgagc aacagcatca tgtacttcag ccacttcgtg      840

cctgtgttcc tgcctgccaa gcctacaaca acaccagccc ctagacctcc aacccctgcc      900

cctacaattg cctctcagcc tctgtctctg aggcccgaag cttgtagacc tgctgctggc      960

ggagctgtgc acaccagagg actggatttc gcctgctttt gggtgctggt ggtcgtgggc     1020

ggagtgctgg cttgttattc tctgctggtc accgtggcct tcatcatctt ttgggtccga     1080

ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac     1140

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc     1200

cag                                                                   1203


<210>  65
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  65
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgcca acatccagat gacccagtct ccatcttctg tgtctgcatc tgtaggagac      120

agagtcacca tcacttgtcg ggcgagtcag gatattagcc gctggttagc ctggtatcag      180

cagaaaccag ggaaagcccc taaactcctg atctatgctg catccagttt gcaaagtggg      240

gtcccatcga ggttcagcgg cagtggatct gggacagatt tcgctctcac tatcagcagc      300

ctgcagcctg aagattttgc aacttactat tgtcaacagg ctgacagtcg tttctcgatc      360

accttcggcc aagggacacg actggagatt aaaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaggtgc agctggtgca gtctggggga      480

ggcttggtac agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc      540

agtagctata gcatgaactg ggtccgccag gctccaggga aggggctgga gtgggtttca      600

tacattagta gtagtagtag taccatacag tacgcagact ctgtgaaggg ccgattcacc      660

atctccagag acaatgccaa gaactcactg tatctgcaaa tgaacagcct gagagacgag      720

gacacggctg tgtattactg tgcgagaggg gactactact acggtatgga cgtctggggc      780

caagggacca cggtcaccgt gagctcagcg gccgcgctga gcaacagcat catgtacttc      840

agccacttcg tgcctgtgtt cctgcctgcc aagcctacaa caacaccagc ccctagacct      900

ccaacccctg cccctacaat tgcctctcag cctctgtctc tgaggcccga agcttgtaga      960

cctgctgctg gcggagctgt gcacaccaga ggactggatt tcgcctgctt ttgggtgctg     1020

gtggtcgtgg gcggagtgct ggcttgttat tctctgctgg tcaccgtggc cttcatcatc     1080

ttttgggtcc gactgaagat ccaggtccga aaggccgcca tcaccagcta cgagaagtct     1140

gatggcgtgt acaccggcct gagcaccaga aaccaggaaa cctacgagac actgaagcac     1200

gagaagcccc cccag                                                      1215


<210>  66
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  66
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg acattcaaat gactcagtcc ccttccagct tgtcagcctc agtaggggac      120

cgggtcacga tcacctgtcg agcgtctgag tcagtggata actacgggat ttctttcatg      180

aactggttcc agcagaagcc cggcaaagct cctaagctcc ttatatatgc agcctcaaat      240

caggggagcg gtgttcctag tcgcttcagt ggaagcggta gcggtacgga ctttacgttg      300

acgataagta gccttcagcc agatgacttt gccacttatt attgtcagca gtctaaggaa      360

gttccttgga cgtttggcca aggaacgaag gtcgaaatca aagggggagg gggctcagga      420

gggggcggca gtggtggtgg aggctctcaa gtccaactcg tacagtctgg cgcggaggtt      480

aaaaagccgg gaagctccgt gaaagtatcc tgtaaggcaa gcggatacac ctttaccgat      540

tataacatgc actgggttag gcaggcgccc ggccaaggtc tggaatggat cggttatatt      600

tatccataca acggtggtac cggctataat cagaagttta agagtaaggc tactattaca      660

gcggatgagt caaccaatac tgcatacatg gagctctcct cactcaggag cgaagatacc      720

gcagtgtatt actgtgcccg agggagacca gccatggact actggggtca gggtaccctt      780

gtgacagtat ctagcgcggc cgcgctgagc aacagcatca tgtacttcag ccacttcgtg      840

cctgtgttcc tgcctgccaa gcctacaaca acaccagccc ctagacctcc aacccctgcc      900

cctacaattg cctctcagcc tctgtctctg aggcccgaag cttgtagacc tgctgctggc      960

ggagctgtgc acaccagagg actggatttc gcctgctttt gggtgctggt ggtcgtgggc     1020

ggagtgctgg cttgttattc tctgctggtc accgtggcct tcatcatctt ttgggtccga     1080

ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac     1140

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc     1200

cag                                                                   1203


<210>  67
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  67
atgaaccggg gagtcccttt taggcacttg cttctggtgc tgcaactggc gctcctccca       60

gcagccactc agggaaagaa agtggtgctg ggcaaaaaag gggatacagt ggaactgacc      120

tgtacagctt cccagaagaa gagcatacaa ttccactgga aaaactccaa ccagataaag      180

attctgggaa atcagggctc cttcttaact aaaggtccat ccaagctgaa tgatcgcgct      240

gactcaagaa gaagcctttg ggaccaagga aactttcccc tgatcatcaa gaatcttaag      300

atagaagact cagatactta catctgtgaa gtggaggacc agaaggagga ggtgcaattg      360

ctagtgttcg gattgactgc caactctgac acccacctgc ttcaggggca gagcctgacc      420

ctgaccttgg agagcccccc tggtagtagc ccctcagtgc aatgtaggag tccaaggggt      480

aaaaacatac agggggggaa gaccctctcc gtgtctcagc tggagctcca ggatagtggc      540

acctggacat gcactgtctt gcagaaccag aagaaggtgg agttcaaaat agacatcgtg      600

gtgctagctt tccagaaggc ctccagcata gtctataaga aagaggggga acaggtggag      660

ttctccttcc cactcgcctt tacagttgaa aagctgacgg gcagtggcga gctgtggtgg      720

caggcggaga gggcttcctc ctccaagtct tggatcacct ttgacctgaa gaacaaggaa      780

gtgtctgtaa aacgggttac ccaggaccct aagctccaga tgggcaagaa gctcccgctc      840

cacctcaccc tgccccaggc cttgcctcag tatgctggct ctggaaacct caccctggcc      900

cttgaagcga aaacaggaaa gttgcatcag gaagtgaacc tggtggtgat gagagccact      960

cagctccaga aaaatttgac ctgtgaggtg tggggaccca cctcccctaa gctgatgctg     1020

agtttgaaac tggagaacaa ggaggcaaag gtctcgaagc gggagaaggc ggtgtgggtg     1080

ctgaaccctg aggcggggat gtggcagtgt ctgctgagtg actcgggaca ggtcctgctg     1140

gaatccaaca tcaaggttct gcccacatgg tccaccccgg tgcagccagc ggccgcgctg     1200

agcaacagca tcatgtactt cagccacttc gtgcctgtgt tcctgcctgc caagcctaca     1260

acaacaccag cccctagacc tccaacccct gcccctacaa ttgcctctca gcctctgtct     1320

ctgaggcccg aagcttgtag acctgctgct ggcggagctg tgcacaccag aggactggat     1380

ttcgcctgct tttgggtgct ggtggtcgtg ggcggagtgc tggcttgtta ttctctgctg     1440

gtcaccgtgg ccttcatcat cttttgggtc cgactgaaga tccaggtccg aaaggccgcc     1500

atcaccagct acgagaagtc tgatggcgtg tacaccggcc tgagcaccag aaaccaggaa     1560

acctacgaga cactgaagca cgagaagccc ccccag                               1596


<210>  68
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  68
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg aagttcagct tgtagaatct ggaggtggat tggttcaacc tggtggctct      120

cttcgcctga gttgtgcagc ctctggtttt actttcaata gttacgctat gcattgggtt      180

cgtcaggctc ctgggaaagg cctggaatgg gtttcagcta ttagtggtaa tggaggtagt      240

actcgttacg cagacagtgt gaaaggtcgc ttcaccatca gccgtgataa ttctaagaac      300

actttgtacc tgcaaatgaa ctccttgcgc gcagaagaca cggctgtgta ctattgtgcc      360

cgtgatcgct ttcggaaggt tcatggtttc gatgtatggg gacaaggtac cctggtaacg      420

gtttctagcg gaggtggtgg gagtggtgga ggcggctcgg gtggaggtgg ttcaggagga      480

ggcggagata tccaaatgac tcaatctcct agttcactgt cagcctctgt tggtgatcgc      540

gtgaccatta cctgccaagc tagccaggat attagcaact acttgaactg gtatcagcag      600

aagcctggca aagccccaaa gctgttgatc tacgatgcaa gtaacttgga aactggcgtc      660

ccaagccgct tctctggatc tggttcaggc accgacttca ctttcactat cagcagcctg      720

cagcctgaag atatcgcaac ctactattgc cagcaggatg ctacttttcc tttgactttc      780

ggccaaggca ccaaggtgga gatcaaggcg gccgcgctga gcaacagcat catgtacttc      840

agccacttcg tgcctgtgtt cctgcctgcc aagcctacaa caacaccagc ccctagacct      900

ccaacccctg cccctacaat tgcctctcag cctctgtctc tgaggcccga agcttgtaga      960

cctgctgctg gcggagctgt gcacaccaga ggactggatt tcgcctgctt ttgggtgctg     1020

gtggtcgtgg gcggagtgct ggcttgttat tctctgctgg tcaccgtggc cttcatcatc     1080

ttttgggtcc gactgaagat ccaggtccga aaggccgcca tcaccagcta cgagaagtct     1140

gatggcgtgt acaccggcct gagcaccaga aaccaggaaa cctacgagac actgaagcac     1200

gagaagcccc cccag                                                      1215


<210>  69
<211>  1194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  69
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg tccagctgca gcagtctgga cctgagctgg taaagcctgg ggcttcagtg      120

aagatgtcct gcaaggcttc tggatacaca ttcactagct atgttatgca ctgggtgaag      180

cagaagcctg ggcagggcct tgagtggatt ggatatatta ttccttacaa tgatgctact      240

aagtacaatg agaagttcaa aggcaaggcc acactgactt cagacaaatc ctccagcaca      300

gcctacatgg agctcagcag cctgacctct gaggactctg cggtctatta ctgtgcacgc      360

tataattacg acgggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      420

ggcggcggag gaagcggagg cggaggatct gggggcggag gctctgacat tgtgatgact      480

cagtctccag ccaccctgtc tgtgactcca ggagatagag tctctctttc ctgcagggcc      540

agccagagta ttagcgacta cttacactgg tatcaacaaa aatcacatga gtctccaagg      600

cttctcatca aatatgcttc ccaatccatc tctggaatcc cctccaggtt cagtggcagt      660

ggatcagggt cagatttcac tctcagtatc aacagtgtgg aacctgaaga tgttggagtg      720

tattactgtc aaaatggtca cagctttcct ccgacgttcg gtggaggcac caagctggaa      780

atcaaagcgg ccgcgctgag caacagcatc atgtacttca gccacttcgt gcctgtgttc      840

ctgcctgcca agcctacaac aacaccagcc cctagacctc caacccctgc ccctacaatt      900

gcctctcagc ctctgtctct gaggcccgaa gcttgtagac ctgctgctgg cggagctgtg      960

cacaccagag gactggattt cgcctgcttt tgggtgctgg tggtcgtggg cggagtgctg     1020

gcttgttatt ctctgctggt caccgtggcc ttcatcatct tttgggtccg actgaagatc     1080

caggtccgaa aggccgccat caccagctac gagaagtctg atggcgtgta caccggcctg     1140

agcaccagaa accaggaaac ctacgagaca ctgaagcacg agaagccccc ccag           1194


<210>  70
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  70
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccc aggtgcaagt gaaagagtct ggccctggac tggtggcccc aagccagtct      120

ctgagcatca catgtaccgt gtccggcttc agcctgacca actatggcgt gcactgggtc      180

cgacagcctc caggcaaagg actggaatgg ctgggagtga tttgggctgg cggcagcacc      240

aactacaaca gcgccctgat gagccggctg agcatctcca aggacaacag caagagccag      300

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatgtacta ctgtgctagc      360

agaggcggca actacggcta cgccctggat tattggggcc agggcacaag cgtgaccgtg      420

tcatctggcg gcggaggaag cggaggcgga ggatctgggg gcggaggctc tggcggaggg      480

ggatctagca tcgtgatgac ccagactcct aagttcctgc tggtgtctgc cggcgacaga      540

gtgaccatca cctgtaaagc cagccagagc gtgtccaacg acgtggcctg gtatcagcag      600

aagcctggac agagccccaa gctgctgatc tacagcgcca gcaacagata caccggcgtg      660

cccgatagat tcaccggctc tggctacggc accgacttca cctttaccat cagcaccgtg      720

caggccgagg atctggccgt gtacttctgc cagcaagact acagctctct cggcggaggc      780

accaagctgg aaatcaaagc ggccgcgctg agcaacagca tcatgtactt cagccacttc      840

gtgcctgtgt tcctgcctgc caagcctaca acaacaccag cccctagacc tccaacccct      900

gcccctacaa ttgcctctca gcctctgtct ctgaggcccg aagcttgtag acctgctgct      960

ggcggagctg tgcacaccag aggactggat ttcgcctgct tttgggtgct ggtggtcgtg     1020

ggcggagtgc tggcttgtta ttctctgctg gtcaccgtgg ccttcatcat cttttgggtc     1080

cgactgaaga tccaggtccg aaaggccgcc atcaccagct acgagaagtc tgatggcgtg     1140

tacaccggcc tgagcaccag aaaccaggaa acctacgaga cactgaagca cgagaagccc     1200

ccccag                                                                1206


<210>  71
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  71
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccc aggttcagct gcagcagtct ggacctgagc tggttaagcc tggcgcctcc      120

gtgaagatga gctgcaagac cagccggtac accttcaccg agtacaccat ccactgggtc      180

cgacagagcc acggcaagag cctggaatgg atcggcggca tcaaccccaa caacggcatc      240

cccaactaca accagaagtt caagggcaga gccacactga ccgtgggcaa gtctagcagc      300

accgcctaca tggaactgcg gagcctgaca agcgaggaca gcgccgtgta cttctgcgcc      360

agaagaagaa tcgcctacgg ctacgatgag ggccacgcca tggattattg gggccaggga      420

acaagcgtga ccgtgtctag tggcggcgga ggaagcggag gcggaggatc tgggggcgga      480

ggctctggcg gagggggatc tgacatcgtg atgacacaga gcccttctag cctggccgtg      540

tccgtgggag agaaagtgac catgagctgc aagagcagcc agagcctgct gtactcccgg      600

aaccagaaga actacctggc ctggttccag cagaagcccg gccagtctcc taagctgctg      660

atcttctggg ccagcaccag agaaagcggc gtgcccgata gattcaccgg cagcggcttt      720

ggcaccgact tcaacctgac aatcagcagc gtgcaggccg aggacctggc tgtgtacgat      780

tgccagcagt acttcagcta ccctctgacc tttggagccg gcaccaagct ggaactgaga      840

gcggccgcgc tgagcaacag catcatgtac ttcagccact tcgtgcctgt gttcctgcct      900

gccaagccta caacaacacc agcccctaga cctccaaccc ctgcccctac aattgcctct      960

cagcctctgt ctctgaggcc cgaagcttgt agacctgctg ctggcggagc tgtgcacacc     1020

agaggactgg atttcgcctg cttttgggtg ctggtggtcg tgggcggagt gctggcttgt     1080

tattctctgc tggtcaccgt ggccttcatc atcttttggg tccgactgaa gatccaggtc     1140

cgaaaggccg ccatcaccag ctacgagaag tctgatggcg tgtacaccgg cctgagcacc     1200

agaaaccagg aaacctacga gacactgaag cacgagaagc ccccccag                  1248


<210>  72
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  72
atgcgcatca gcaagcccca cctgcgcagc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac cgaggccggc atccacgtgt tcatcctggg ctgcttcagc      120

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac      240

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg      300

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag      420

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac      480

accagcggct ccgagaagga cgagctgtaa                                       510


<210>  73
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  73

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Ser Glu Lys Asp Glu Leu 
                165                 


<210>  74
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  74
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggcca tggcgcaagt aaaactccaa gaatctgggg cggagctggt gaaaccgggg      120

gcgtctgtga agatgagctg taaagcatca ggctacacct tcacctccta taatatgcac      180

tgggtgaaac aaacacccgg acagggcctc gaatggattg gtgccatcta tcctggaaat      240

ggtgatacct catataatca gaagtttaag ggcaaggcta cgcttactgc ggataaaagc      300

tcttccactg cttacatgca actgagcagt ctcacttcag aggactcagc cgattattat      360

tgtgcccgca gcaactacta tggtagttca tactggtttt tcgacgtttg ggggcaaggt      420

accaccgtca cggtttcttc tggtgggggc ggaagcgggg gtggaggatc tgggggcggt      480

ggttcagaca ttgaactcac ccagagccct actattctga gcgcgtctcc aggtgaaaaa      540

gttacgatga cgtgcagagc atcaagtagt gtgaattata tggattggta tcaaaagaag      600

ccaggctcat ccccaaaacc gtggatctat gcaactagca acctcgcgtc aggggtgcca      660

gcaaggtttt ccggaagtgg ttctggcaca tcttatagtc tcaccatttc ccgagtggag      720

gctgaggatg cggccactta ttactgccag caatggtcat tcaatccccc aacatttggt      780

ggcggaacaa aactcgaaat taaacgggcg gccgcgctga gcaacagcat catgtacttc      840

agccacttcg tgcctgtgtt cctgcctgcc aagcctacaa caacaccagc ccctagacct      900

ccaacccctg cccctacaat tgcctctcag cctctgtctc tgaggcccga agcttgtaga      960

cctgctgctg gcggagctgt gcacaccaga ggactggatt tcgcctgctt ttgggtgctg     1020

gtggtcgtgg gcggagtgct ggcttgttat tctctgctgg tcaccgtggc cttcatcatc     1080

ttttgggtcc gactgaagat ccaggtccga aaggccgcca tcaccagcta cgagaagtct     1140

gatggcgtgt acaccggcct gagcaccaga aaccaggaaa cctacgagac actgaagcac     1200

gagaagcccc cccag                                                      1215


<210>  75
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  75
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg atatcgagct cacccaatct ccaaaattca tgtccacatc agtaggagac      120

agggtcagcg tcacctgcaa ggccagtcag aatgtggata ctaatgtagc gtggtatcaa      180

caaaaaccag ggcaatctcc tgaaccactg cttttctcgg catcctaccg ttacactgga      240

gtccctgatc gcttcacagg cagtggatct gggacagatt tcactctcac catcagcaat      300

gtgcagtctg aagacttggc agagtatttc tgtcagcaat ataacagcta tcctctgacg      360

ttcggtggcg gcaccaagct ggaaatcaaa cgggctgccg cagaaggtgg aggcggttca      420

ggtggcggag gttccggcgg aggtggctct ggcggtggcg gatcggccat ggcccaggtg      480

aagctgcagc agtcaggagg gggcttggtg caacctggag gctccatgaa actctcctgt      540

gttgtctctg gattcacttt cagtaattac tggatgaact gggtccgcca gtctccagag      600

aaggggcttg agtggattgc agaaattaga ttgaaatcca ataattttgg aagatattat      660

gcggagtctg tgaaagggag gttcaccatc tcaagagatg attccaaaag tagtgcctac      720

ctgcaaatga tcaacctaag agctgaagat actggcattt attactgtac cagttatggt      780

aactacgttg ggcactattt tgaccactgg ggccaaggga ccacggtcac cgtatcgagt      840

gcggccgcgc tgagcaacag catcatgtac ttcagccact tcgtgcctgt gttcctgcct      900

gccaagccta caacaacacc agcccctaga cctccaaccc ctgcccctac aattgcctct      960

cagcctctgt ctctgaggcc cgaagcttgt agacctgctg ctggcggagc tgtgcacacc     1020

agaggactgg atttcgcctg cttttgggtg ctggtggtcg tgggcggagt gctggcttgt     1080

tattctctgc tggtcaccgt ggccttcatc atcttttggg tccgactgaa gatccaggtc     1140

cgaaaggccg ccatcaccag ctacgagaag tctgatggcg tgtacaccgg cctgagcacc     1200

agaaaccagg aaacctacga gacactgaag cacgagaagc ccccccag                  1248


<210>  76
<211>  6787
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  76
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct       60

gacgtcgacg gatcgggaga tctcccgatc ccctatggtg cactctcagt acaatctgct      120

ctgatgccgc atagttaagc cagtatctgc tccctgcttg tgtgttggag gtcgctgagt      180

agtgcgcgag caaaatttaa gctacaacaa ggcaaggctt gaccgacaat tgcatgaaga      240

atctgcttag ggttaggcgt tttgcgctgc ttcgggatcc gctgaccaaa agagcaccaa      300

aggcgccctg accttcagcc cctacctgcg ctccggtgcc cgtcagtggg cagagcgcac      360

atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag      420

aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga      480

gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg      540

gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg gcctctttac      600

gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg tgattcttga      660

tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc      720

ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg      780

gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg      840

atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct      900

gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg      960

cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc     1020

tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg     1080

ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg     1140

ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc     1200

acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga     1260

gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt     1320

aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga     1380

agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg     1440

atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt     1500

gtcgtgataa tacgactcac tatagggaga cccaagctgg aattcgccac catggactgg     1560

atctggcgga ttctgtttct cgtgggagct gccacaggcg ctcattctgc tcagcctgcc     1620

gatgttgtaa tgacgcagtc acccctgtca ctcccggtca cacccggaga accagcgtca     1680

attagctgcc gatctagcca aagtttgctt cattccaatg gttacaatta tctcgactgg     1740

tacttgcaga aacccggcca atcccctcag ctgctcatct accttgggtc taatagggca     1800

tctggggttc ccgataggtt ctctggctcc gggagcggca ccgactttac gttgaaaatc     1860

tctagggttg aggcggaaga cgtaggcgtt tactattgca tgcaggggac ccactggccg     1920

ctgaccttcg gccagggcac caaggttgaa ataaaaggcg gcggaggaag cggaggcgga     1980

ggatctgggg gcggaggctc tggcggaggg ggatctcagg tacagctcca ggaatcagga     2040

cccggtttgg ttaagccctc cgggaccctt tccctcacgt gtgcagtctc aggtgggtca     2100

attagttctt ccaattggtg gtcttgggtg cggcaaccac ctggtaaagg tctcgagtgg     2160

ataggggaaa tttatcatag tggctccacc aattataacc cctcactcaa gtccagggtt     2220

acgatatctg tggacaaaag taaaaaccaa ttctccctca aacttagtag tgtaacagcg     2280

gcagacaccg cggtgtacta ctgcgcacgg tggacaggcc gaactgatgc ctttgacatt     2340

tggggacagg gaactatggt gactgtgtca tccgcggccg cgctgagcaa cagcatcatg     2400

tacttcagcc acttcgtgcc tgtgttcctg cctgccaagc ctacaacaac accagcccct     2460

agacctccaa cccctgcccc tacaattgcc tctcagcctc tgtctctgag gcccgaagct     2520

tgtagacctg ctgctggcgg agctgtgcac accagaggac tggatttcgc ctgcttttgg     2580

gtgctggtgg tcgtgggcgg agtgctggct tgttattctc tgctggtcac cgtggccttc     2640

atcatctttt gggtccgact gaagatccag gtccgaaagg ccgccatcac cagctacgag     2700

aagtctgatg gcgtgtacac cggcctgagc accagaaacc aggaaaccta cgagacactg     2760

aagcacgaga agccccccca gggatctgga gctactaact tcagcctgct gaagcaggct     2820

ggagacgtgg aggagaaccc tggacctatg tggcagctgc tgctgcctac agctctcctg     2880

ctgctggtgt ccgccggcat gagaaccgag gatctgccta aggccgtggt gttcctggaa     2940

ccccagtggt acagagtgct ggaaaaggac agcgtgaccc tgaagtgcca gggcgcctac     3000

agccccgagg acaatagcac ccagtggttc cacaacgaga gcctgatcag cagccaggcc     3060

agcagctact tcatcgacgc cgccaccgtg gacgacagcg gcgagtatag atgccagacc     3120

aacctgagca ccctgagcga ccccgtgcag ctggaagtgc acatcggatg gctgctgctg     3180

caggccccca gatgggtgtt caaagaagag gaccccatcc acctgagatg ccactcttgg     3240

aagaacaccg ccctgcacaa agtgacctac ctgcagaacg gcaagggcag aaagtacttc     3300

caccacaaca gcgacttcta catccccaag gccaccctga aggactccgg ctcctacttc     3360

tgcagaggcc tcgtgggcag caagaacgtg tccagcgaga cagtgaacat caccatcacc     3420

cagggcctgg ccgtgtctac catcagcagc tttttcccac ccggctacca ggtgtccttc     3480

tgcctcgtga tggtgctgct gttcgccgtg gacaccggcc tgtacttcag cgtgaaaaca     3540

aacatcagaa gcagcacccg ggactggaag gaccacaagt tcaagtggcg gaaggacccc     3600

caggacaagt gaaattccgc ccctctcccc cccccccctc tccctccccc ccccctaacg     3660

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     3720

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     3780

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     3840

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     3900

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     3960

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     4020

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     4080

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     4140

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     4200

gataaccgcc accatgtacc ggatgcagct gctgagctgt atcgccctgt ctctggccct     4260

cgtgaccaac agcgccccta ccagcagcag caccaagaaa acccagctgc agctggaaca     4320

tctgctgctg gacctgcaga tgatcctgaa cggcatcaac aactacaaga accccaagct     4380

gacccggatg ctgaccttca agttctacat gcccaagaag gccaccgaac tgaaacatct     4440

gcagtgcctg gaagaggaac tgaagcccct ggaagaagtg ctgaacctgg cccagagcaa     4500

gaacttccac ctgaggccca gggacctgat cagcaacatc aacgtgatcg tgctggaact     4560

gaaaggcagc gagacaacct tcatgtgcga gtacgccgac gagacagcta ccatcgtgga     4620

atttctgaac cggtggatca ccttctgcca gagcatcatc agcaccctga ccggctccga     4680

gaaggacgag ctgtgagcgg ccgcccgctg atcagcctcg aacgagattt cgattccacc     4740

gccgccttct atgaaaggtt gggcttcgga atcgttttcc gggacgccgg ctggatgatc     4800

ctccagcgcg gggatctcat gctggagttc ttcgcccacc ccaacttgtt tattgcagct     4860

tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca     4920

ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctgtgcggtg     4980

ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta tccccggatc     5040

ctgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     5100

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     5160

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     5220

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     5280

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     5340

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     5400

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     5460

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     5520

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     5580

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     5640

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     5700

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     5760

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     5820

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     5880

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     5940

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     6000

accacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     6060

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     6120

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat     6180

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     6240

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     6300

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     6360

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     6420

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     6480

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     6540

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     6600

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     6660

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     6720

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     6780

atttgaa                                                               6787


