                               SEQUENCE LISTING

<110> MARVELBIOME, INC.
 
<120> MICROBIAL COMPOSITIONS COMPRISING ELLAGITANNIN AND METHODS OF USE

<130> 2013404-0018

<140> PCT/US2019/059724
<141> 2019-11-04

<150> 62/909,736
<151> 2019-10-02

<150> 62/755,880
<151> 2018-11-05

<160> 9     

<170> PatentIn version 3.5

<210> 1
<211> 1410
<212> DNA
<213> Lactobacillus plantarum

<400> 1
atgagtaacc gattgatttt tgatgctgac tggctggtgc cggaacaggt ccaagttgcc       60

gggcaggcta ttcaatatta tgctgcccgt aatattcagt acgttcagca tccagtcgca      120

gcgattcagg tcctaaacgt ttttgtacca gccgcatact tgcatggcag ttcagtcaat      180

ggttatcagc gggcaacggc gccaattctg atgccgaata cggtcggcgg ttatttgcca      240

ggaccggcgg atgatccgca acgtgtcact tggccgacga atgcagggac gattcaacag      300

gcacttaaac gcggttacgt tgtggtggcc gctggaattc gcggtcgtac gacggttgat      360

aagtctgggc aacgggtcgg gcaagcgccg gcttttatcg tagatatgaa ggcggcaatc      420

cgttacgtta agtataatca gggccggctg ccaggtgaca cgaaccggat catcacgaat      480

ggaacgagtg ctgggggtgc cacttcggct ttagcgggtg cgagtggcaa ttcggcttat      540

tttgaaccag ccttaactgc gctcggggca gcaccggcga ctgacgatat ctttgcggtg      600

tcagcttact gcccgattca taatctggaa cacgcagaca tggcctacga gtggcagttt      660

aatggtatta atgactggca ccgttatcag cctgttgcgg ggacgaccaa gaatgggcga      720

ccaaaatttg aaccggttag tggtcagctc acagttgaag aacaggccct ttcgttggcg      780

ttaaaagccc agttcagtac ctacttgaac cagttgaaac tcacggccag tgacgggacg      840

cacttgacgc ttaatgaggc gggaatgggt tcatttcgtg atgttgttcg ccaattattg      900

atatcatctg ctcagacggc attcgatcaa gggacggata ttcataagta cgcaggcttt      960

gtcgttactg gaaatcaggt gacggacttg gatttatcag cttatttgaa gtcgttaact     1020

cgcatgaaag ccgtcccggc gtttgaccaa ttagatttga cgagtccaga gaataatttg     1080

tttggcgatg caacggcgaa agccaagcac tttacggcct tggcacagac gcgaagtacg     1140

gtgacggcac aactagcgga cgctgagctg attcaggcga ttaatccgct cagttactta     1200

acgacaactt cgtcacgagt tgctaagcac tggcggattc gccacggtgc ggccgaccga     1260

gatacgagtt ttgcaatccc gattattcta gcaataatgt tagaaaatca tggttatggc     1320

attgattttg cgctaccgtg ggatattccc cacagtggtg actatgattt aggcgattta     1380

ttttcctgga ttgatggctt gtgccaatga                                      1410


<210> 2
<211> 469
<212> PRT
<213> Lactobacillus plantarum

<400> 2
Met Ser Asn Arg Leu Ile Phe Asp Ala Asp Trp Leu Val Pro Glu Gln 
1               5                   10                  15      


Val Gln Val Ala Gly Gln Ala Ile Gln Tyr Tyr Ala Ala Arg Asn Ile 
            20                  25                  30          


Gln Tyr Val Gln His Pro Val Ala Ala Ile Gln Val Leu Asn Val Phe 
        35                  40                  45              


Val Pro Ala Ala Tyr Leu His Gly Ser Ser Val Asn Gly Tyr Gln Arg 
    50                  55                  60                  


Ala Thr Ala Pro Ile Leu Met Pro Asn Thr Val Gly Gly Tyr Leu Pro 
65                  70                  75                  80  


Gly Pro Ala Asp Asp Pro Gln Arg Val Thr Trp Pro Thr Asn Ala Gly 
                85                  90                  95      


Thr Ile Gln Gln Ala Leu Lys Arg Gly Tyr Val Val Val Ala Ala Gly 
            100                 105                 110         


Ile Arg Gly Arg Thr Thr Val Asp Lys Ser Gly Gln Arg Val Gly Gln 
        115                 120                 125             


Ala Pro Ala Phe Ile Val Asp Met Lys Ala Ala Ile Arg Tyr Val Lys 
    130                 135                 140                 


Tyr Asn Gln Gly Arg Leu Pro Gly Asp Thr Asn Arg Ile Ile Thr Asn 
145                 150                 155                 160 


Gly Thr Ser Ala Gly Gly Ala Thr Ser Ala Leu Ala Gly Ala Ser Gly 
                165                 170                 175     


Asn Ser Ala Tyr Phe Glu Pro Ala Leu Thr Ala Leu Gly Ala Ala Pro 
            180                 185                 190         


Ala Thr Asp Asp Ile Phe Ala Val Ser Ala Tyr Cys Pro Ile His Asn 
        195                 200                 205             


Leu Glu His Ala Asp Met Ala Tyr Glu Trp Gln Phe Asn Gly Ile Asn 
    210                 215                 220                 


Asp Trp His Arg Tyr Gln Pro Val Ala Gly Thr Thr Lys Asn Gly Arg 
225                 230                 235                 240 


Pro Lys Phe Glu Pro Val Ser Gly Gln Leu Thr Val Glu Glu Gln Ala 
                245                 250                 255     


Leu Ser Leu Ala Leu Lys Ala Gln Phe Ser Thr Tyr Leu Asn Gln Leu 
            260                 265                 270         


Lys Leu Thr Ala Ser Asp Gly Thr His Leu Thr Leu Asn Glu Ala Gly 
        275                 280                 285             


Met Gly Ser Phe Arg Asp Val Val Arg Gln Leu Leu Ile Ser Ser Ala 
    290                 295                 300                 


Gln Thr Ala Phe Asp Gln Gly Thr Asp Ile His Lys Tyr Ala Gly Phe 
305                 310                 315                 320 


Val Val Thr Gly Asn Gln Val Thr Asp Leu Asp Leu Ser Ala Tyr Leu 
                325                 330                 335     


Lys Ser Leu Thr Arg Met Lys Ala Val Pro Ala Phe Asp Gln Leu Asp 
            340                 345                 350         


Leu Thr Ser Pro Glu Asn Asn Leu Phe Gly Asp Ala Thr Ala Lys Ala 
        355                 360                 365             


Lys His Phe Thr Ala Leu Ala Gln Thr Arg Ser Thr Val Thr Ala Gln 
    370                 375                 380                 


Leu Ala Asp Ala Glu Leu Ile Gln Ala Ile Asn Pro Leu Ser Tyr Leu 
385                 390                 395                 400 


Thr Thr Thr Ser Ser Arg Val Ala Lys His Trp Arg Ile Arg His Gly 
                405                 410                 415     


Ala Ala Asp Arg Asp Thr Ser Phe Ala Ile Pro Ile Ile Leu Ala Ile 
            420                 425                 430         


Met Leu Glu Asn His Gly Tyr Gly Ile Asp Phe Ala Leu Pro Trp Asp 
        435                 440                 445             


Ile Pro His Ser Gly Asp Tyr Asp Leu Gly Asp Leu Phe Ser Trp Ile 
    450                 455                 460                 


Asp Gly Leu Cys Gln 
465                 


<210> 3
<211> 1473
<212> DNA
<213> Lactobacillus plantarum

<400> 3
atggcagaac aaccatggga tttgcgtcgc gtgcttgatg agatcaagga tgatccaaag       60

aactatcatg aaactgacgt cgaagttgat ccaaatgcgg aactttctgg tgtttatcgg      120

tatatcggtg ctggtgggac cgttcaacgg ccaacgcaag agggtccagc aatgatgttt      180

aacaacgtta aggggtttcc tgatacgcgg gtcttgactg gattgatggc gagtcgccgg      240

cgcgttggta agatgttcca ccacgattat cagacgttag ggcaatactt gaacgaagca      300

gtctctaatc cagtggcgcc agaaacggtt gctgaagcgg atgcgccagc tcacgatgtc      360

gtttataaag cgacggatga aggctttgat attcgtaagt tagtggcagc accaacgaat      420

acgccccaag atgctggacc atatattacg gtcggtgtgg tgtttggctc aagcatggac      480

aagtctaaga gtgatgtgac gattcaccga atggtccttg aagataagga taagttaggg      540

atttatatca tgcctggcgg tcggcacatt ggtgcgtttg cggaagagta tgagaaagct      600

aacaagccaa tgccaattac aattaatatt ggtttggatc cagccattac gattggtgca      660

actttcgaac caccgaccac gccattcggt tataacgaat taggtgttgc tggtgcgatt      720

cggaaccaag ctgttcaatt agttgacggg gtgaccgtcg atgaaaaggc gattgcgcgt      780

tctgaatata cgcttgaggg gtacattatg cctaacgaac gtattcagga agatatcaat      840

acgcatacgg gcaaggcgat gcctgaattc ccgggttatg atggtgacgc caacccagct      900

ttacaagtga ttaaggtgac ggcggtgact catcggaaga atgccatcat gcaaagcgtg      960

attggaccat ccgaagaaca tgtcagcatg gcgggaattc caactgaagc tagtatctta     1020

caattggtta accgtgccat tcctggtaaa gtgacgaatg tttataatcc gccggctggt     1080

ggtggtaagt tgatgaccat catgcagatt cacaaggata atgaagcgga tgaaggaatt     1140

caacggcaag ctgccttgct tgcgttctca gcctttaagg aattgaagac tgttatcctg     1200

gttgatgaag atgttgatat ttttgatatg aatgatgtga tttggacgat gaatacccgt     1260

ttccaagccg atcaggactt gatggtctta tcaggcatgc ggaatcatcc gttggaccca     1320

tcggaacgcc cacaatatga tccaaagtcg attcgtttcc gtgggatgag ttctaaacta     1380

gtgattgatg gcaccgtacc attcgatatg aaggaccaat ttgaacgggc ccaattcatg     1440

aaagtggctg actgggagaa gtatttgaag taa                                  1473


<210> 4
<211> 490
<212> PRT
<213> Lactobacillus plantarum

<400> 4
Met Ala Glu Gln Pro Trp Asp Leu Arg Arg Val Leu Asp Glu Ile Lys 
1               5                   10                  15      


Asp Asp Pro Lys Asn Tyr His Glu Thr Asp Val Glu Val Asp Pro Asn 
            20                  25                  30          


Ala Glu Leu Ser Gly Val Tyr Arg Tyr Ile Gly Ala Gly Gly Thr Val 
        35                  40                  45              


Gln Arg Pro Thr Gln Glu Gly Pro Ala Met Met Phe Asn Asn Val Lys 
    50                  55                  60                  


Gly Phe Pro Asp Thr Arg Val Leu Thr Gly Leu Met Ala Ser Arg Arg 
65                  70                  75                  80  


Arg Val Gly Lys Met Phe His His Asp Tyr Gln Thr Leu Gly Gln Tyr 
                85                  90                  95      


Leu Asn Glu Ala Val Ser Asn Pro Val Ala Pro Glu Thr Val Ala Glu 
            100                 105                 110         


Ala Asp Ala Pro Ala His Asp Val Val Tyr Lys Ala Thr Asp Glu Gly 
        115                 120                 125             


Phe Asp Ile Arg Lys Leu Val Ala Ala Pro Thr Asn Thr Pro Gln Asp 
    130                 135                 140                 


Ala Gly Pro Tyr Ile Thr Val Gly Val Val Phe Gly Ser Ser Met Asp 
145                 150                 155                 160 


Lys Ser Lys Ser Asp Val Thr Ile His Arg Met Val Leu Glu Asp Lys 
                165                 170                 175     


Asp Lys Leu Gly Ile Tyr Ile Met Pro Gly Gly Arg His Ile Gly Ala 
            180                 185                 190         


Phe Ala Glu Glu Tyr Glu Lys Ala Asn Lys Pro Met Pro Ile Thr Ile 
        195                 200                 205             


Asn Ile Gly Leu Asp Pro Ala Ile Thr Ile Gly Ala Thr Phe Glu Pro 
    210                 215                 220                 


Pro Thr Thr Pro Phe Gly Tyr Asn Glu Leu Gly Val Ala Gly Ala Ile 
225                 230                 235                 240 


Arg Asn Gln Ala Val Gln Leu Val Asp Gly Val Thr Val Asp Glu Lys 
                245                 250                 255     


Ala Ile Ala Arg Ser Glu Tyr Thr Leu Glu Gly Tyr Ile Met Pro Asn 
            260                 265                 270         


Glu Arg Ile Gln Glu Asp Ile Asn Thr His Thr Gly Lys Ala Met Pro 
        275                 280                 285             


Glu Phe Pro Gly Tyr Asp Gly Asp Ala Asn Pro Ala Leu Gln Val Ile 
    290                 295                 300                 


Lys Val Thr Ala Val Thr His Arg Lys Asn Ala Ile Met Gln Ser Val 
305                 310                 315                 320 


Ile Gly Pro Ser Glu Glu His Val Ser Met Ala Gly Ile Pro Thr Glu 
                325                 330                 335     


Ala Ser Ile Leu Gln Leu Val Asn Arg Ala Ile Pro Gly Lys Val Thr 
            340                 345                 350         


Asn Val Tyr Asn Pro Pro Ala Gly Gly Gly Lys Leu Met Thr Ile Met 
        355                 360                 365             


Gln Ile His Lys Asp Asn Glu Ala Asp Glu Gly Ile Gln Arg Gln Ala 
    370                 375                 380                 


Ala Leu Leu Ala Phe Ser Ala Phe Lys Glu Leu Lys Thr Val Ile Leu 
385                 390                 395                 400 


Val Asp Glu Asp Val Asp Ile Phe Asp Met Asn Asp Val Ile Trp Thr 
                405                 410                 415     


Met Asn Thr Arg Phe Gln Ala Asp Gln Asp Leu Met Val Leu Ser Gly 
            420                 425                 430         


Met Arg Asn His Pro Leu Asp Pro Ser Glu Arg Pro Gln Tyr Asp Pro 
        435                 440                 445             


Lys Ser Ile Arg Phe Arg Gly Met Ser Ser Lys Leu Val Ile Asp Gly 
    450                 455                 460                 


Thr Val Pro Phe Asp Met Lys Asp Gln Phe Glu Arg Ala Gln Phe Met 
465                 470                 475                 480 


Lys Val Ala Asp Trp Glu Lys Tyr Leu Lys 
                485                 490 


<210> 5
<211> 564
<212> DNA
<213> Lactobacillus plantarum

<400> 5
atgaaacgaa ttgttgtggg aatcacggga gcgtccggta cgatttacgc ggtcgactta       60

ttagaaaagt tacatcagcg gccagatgtt gaagttcatc tggtaatgag tgcgtgggct      120

aaaaaaaact tggagttaga gactgattac tcgctcgcgc agctgacggc gctcgcggat      180

gctacttatc gggctaatga ccaaggcgca gcgattgcca gcggttcgtt tttgaatgac      240

ggaatggtca ttgtcccagc tagtatgaag acggtagcag ggattgcgta cggcttcggt      300

gataatttaa tatcgcgggc tgctgatgtc acgattaaag aacaacgtaa acttgtgatt      360

gttccacgtg aaacaccgtt aagcgtgatt catttagaaa atctaacgaa gttggcaaaa      420

ctcggtgccc aaattattcc accgattccc gcgttttata atcatccgca atccattcag      480

gatctggtca atcatcaaac catgaaaatt ttagatgcgt ttcatattca taatgaaact      540

gatcgccgtt gggaggggga ttaa                                             564


<210> 6
<211> 187
<212> PRT
<213> Lactobacillus plantarum

<400> 6
Met Lys Arg Ile Val Val Gly Ile Thr Gly Ala Ser Gly Thr Ile Tyr 
1               5                   10                  15      


Ala Val Asp Leu Leu Glu Lys Leu His Gln Arg Pro Asp Val Glu Val 
            20                  25                  30          


His Leu Val Met Ser Ala Trp Ala Lys Lys Asn Leu Glu Leu Glu Thr 
        35                  40                  45              


Asp Tyr Ser Leu Ala Gln Leu Thr Ala Leu Ala Asp Ala Thr Tyr Arg 
    50                  55                  60                  


Ala Asn Asp Gln Gly Ala Ala Ile Ala Ser Gly Ser Phe Leu Asn Asp 
65                  70                  75                  80  


Gly Met Val Ile Val Pro Ala Ser Met Lys Thr Val Ala Gly Ile Ala 
                85                  90                  95      


Tyr Gly Phe Gly Asp Asn Leu Ile Ser Arg Ala Ala Asp Val Thr Ile 
            100                 105                 110         


Lys Glu Gln Arg Lys Leu Val Ile Val Pro Arg Glu Thr Pro Leu Ser 
        115                 120                 125             


Val Ile His Leu Glu Asn Leu Thr Lys Leu Ala Lys Leu Gly Ala Gln 
    130                 135                 140                 


Ile Ile Pro Pro Ile Pro Ala Phe Tyr Asn His Pro Gln Ser Ile Gln 
145                 150                 155                 160 


Asp Leu Val Asn His Gln Thr Met Lys Ile Leu Asp Ala Phe His Ile 
                165                 170                 175     


His Asn Glu Thr Asp Arg Arg Trp Glu Gly Asp 
            180                 185         


<210> 7
<211> 411
<212> DNA
<213> Lactobacillus plantarum

<400> 7
atggcaactt ttacgactga gcaggccggg tatcaaatgc aagcaatact ccaagtgatt       60

ggatatgact tgttgatcgt cgttaccggt gggaccaatc cccatattgg tgacgtgacc      120

acactaactg ccagcacggt tcccgaaacg gttaagtttc ccagccatga tggtcgcttc      180

cacaaagata actttatttc ggaacgaatg gccaagcgga ttcagcgtta tctagctgga      240

agctgtacaa ttactgcggg aattcatgtc aaccaaatta ctaaagcaca aatagcagct      300

gcggcaccaa tgacggatga cctcagccgc cagattatta gctggttaca ggcccatccc      360

gtccaggctg aaaagccgga atattatgga caagacgagc aaccgcggta g               411


<210> 8
<211> 136
<212> PRT
<213> Lactobacillus plantarum

<400> 8
Met Ala Thr Phe Thr Thr Glu Gln Ala Gly Tyr Gln Met Gln Ala Ile 
1               5                   10                  15      


Leu Gln Val Ile Gly Tyr Asp Leu Leu Ile Val Val Thr Gly Gly Thr 
            20                  25                  30          


Asn Pro His Ile Gly Asp Val Thr Thr Leu Thr Ala Ser Thr Val Pro 
        35                  40                  45              


Glu Thr Val Lys Phe Pro Ser His Asp Gly Arg Phe His Lys Asp Asn 
    50                  55                  60                  


Phe Ile Ser Glu Arg Met Ala Lys Arg Ile Gln Arg Tyr Leu Ala Gly 
65                  70                  75                  80  


Ser Cys Thr Ile Thr Ala Gly Ile His Val Asn Gln Ile Thr Lys Ala 
                85                  90                  95      


Gln Ile Ala Ala Ala Ala Pro Met Thr Asp Asp Leu Ser Arg Gln Ile 
            100                 105                 110         


Ile Ser Trp Leu Gln Ala His Pro Val Gln Ala Glu Lys Pro Glu Tyr 
        115                 120                 125             


Tyr Gly Gln Asp Glu Gln Pro Arg 
    130                 135     


<210> 9
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40  


