                         SEQUENCE LISTING

<110>  XYPHOS BIOSCIENCES INC.
 
<120>  NON-NATURAL NKG2D RECEPTORS THAT DO NOT DIRECTLY SIGNAL THE CELLS
        TO WHICH THEY ARE ATTACHED

<130>  A251193

<150>  US 62/755,776
<151>  2018-11-05

<160>  202   

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide MICA alpha1-alpha2 domain

<400>  1

Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp 
1               5                   10                  15      


Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly 
            20                  25                  30          


Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln 
        35                  40                  45              


Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu 
    50                  55                  60                  


Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala 
65                  70                  75                  80  


His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg 
                85                  90                  95      


Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe 
            100                 105                 110         


Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu 
        115                 120                 125             


Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val 
    130                 135                 140                 


Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His 
145                 150                 155                 160 


Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser 
                165                 170                 175     


Gly Val Val Leu Arg Arg Thr 
            180             


<210>  2
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide MICB alpha1-alpha2 domain

<400>  2

Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp 
1               5                   10                  15      


Glu Ser Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr 
    50                  55                  60                  


Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val 
                85                  90                  95      


Cys Glu Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala 
145                 150                 155                 160 


Met Gln Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ala Ile Arg Arg Thr 
            180         


<210>  3
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP1 alpha1-alpha2 domain

<400>  3

Ala Ala Glu Pro His Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys 
1               5                   10                  15      


Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly Leu Val Asp Glu 
            20                  25                  30          


Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys Ala Lys Ala Phe 
        35                  40                  45              


Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr Trp Glu Glu Gln 
    50                  55                  60                  


Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys Gly Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln 
                85                  90                  95      


Ala Arg Met Ser Cys Glu His Glu Ala His Gly His Gly Arg Gly Ser 
            100                 105                 110         


Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn 
        115                 120                 125             


Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys Lys Met Thr Glu 
    130                 135                 140                 


Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe Gln Lys Ile Ser 
145                 150                 155                 160 


Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu 
                165                 170                 175     


Gln Met Leu Asp Pro Thr Lys Pro Pro Met Val 
            180                 185         


<210>  4
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP2 alpha1-alpha2 domain

<400>  4

Ala Ala Glu Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys 
1               5                   10                  15      


Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu 
            20                  25                  30          


Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val 
        35                  40                  45              


Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln 
    50                  55                  60                  


Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Arg 
65                  70                  75                  80  


Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln 
                85                  90                  95      


Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser 
            100                 105                 110         


Trp Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu 
        115                 120                 125             


Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu 
    130                 135                 140                 


Lys Trp Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe Ser 
145                 150                 155                 160 


Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp 
                165                 170                 175     


Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Pro Met Val 
            180                 185                 


<210>  5
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP3 alpha1-alpha2 domain

<400>  5

Ala Ala Glu Pro His Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu 
1               5                   10                  15      


Pro Arg His Gly Gln Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln 
            20                  25                  30          


Lys Asn Phe Leu Ser Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met 
        35                  40                  45              


Gly His Leu Glu Glu Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln 
    50                  55                  60                  


Leu Glu Met Leu Arg Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala 
65                  70                  75                  80  


Asp Thr Glu Leu Glu Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln 
                85                  90                  95      


Val Arg Met Ser Cys Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser 
            100                 105                 110         


Trp Gln Phe Ser Phe Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn 
        115                 120                 125             


Asn Arg Lys Trp Thr Val Val His Ala Gly Ala Arg Arg Met Lys Glu 
    130                 135                 140                 


Lys Trp Glu Lys Asp Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser 
145                 150                 155                 160 


Met Arg Asp Cys Lys Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys 
                165                 170                 175     


Lys Arg Leu Glu Pro Thr Ala Pro Pro Met Val 
            180                 185         


<210>  6
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP4 alpha1-alpha2 domain

<400>  6

Ala Ala Glu Pro His Ser Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu 
1               5                   10                  15      


Ser Arg Pro Gly Gln Pro Trp Cys Glu Ala Gln Val Phe Leu Asn Lys 
            20                  25                  30          


Asn Leu Phe Leu Gln Tyr Asn Ser Asp Asn Asn Met Val Lys Pro Leu 
        35                  40                  45              


Gly Leu Leu Gly Lys Lys Val Tyr Ala Thr Ser Thr Trp Gly Glu Leu 
    50                  55                  60                  


Thr Gln Thr Leu Gly Glu Val Gly Arg Asp Leu Arg Met Leu Leu Cys 
65                  70                  75                  80  


Asp Ile Lys Pro Gln Ile Lys Thr Ser Asp Pro Ser Thr Leu Gln Val 
                85                  90                  95      


Glu Met Phe Cys Gln Arg Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp 
            100                 105                 110         


Gln Phe Ala Thr Asn Gly Glu Lys Ser Leu Leu Phe Asp Ala Met Asn 
        115                 120                 125             


Met Thr Trp Thr Val Ile Asn His Glu Ala Ser Lys Ile Lys Glu Thr 
    130                 135                 140                 


Trp Lys Lys Asp Arg Gly Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys 
145                 150                 155                 160 


Gly Asp Cys Asp His Trp Leu Arg Glu Phe Leu Gly His Trp Glu Ala 
                165                 170                 175     


Met Pro Glu Pro Thr Val Ser Pro Pro Met Val 
            180                 185         


<210>  7
<211>  198
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP5 alpha1-alpha2 domain

<400>  7

Gly Leu Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Ser Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Ile Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Gly Ser Gly 
            100                 105                 110         


Ser Trp Gln Leu Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Asn Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Met Thr Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Thr Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Pro Thr Met Ser Ser 
            180                 185                 190         


Gly Thr Ala Gln Pro Arg 
        195             


<210>  8
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP6 alpha1-alpha2 domain

<400>  8

Ala Ala Glu Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys 
1               5                   10                  15      


Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu 
            20                  25                  30          


Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val 
        35                  40                  45              


Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln 
    50                  55                  60                  


Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln 
                85                  90                  95      


Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser 
            100                 105                 110         


Trp Gln Phe Ser Ile Asp Gly Gln Thr Phe Leu Leu Phe Asp Ser Glu 
        115                 120                 125             


Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu 
    130                 135                 140                 


Lys Trp Glu Asn Asp Lys Asp Val Ala Met Ser Phe His Tyr Ile Ser 
145                 150                 155                 160 


Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp 
                165                 170                 175     


Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Pro Met Val 
            180                 185                 


<210>  9
<211>  161
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide OMCP alpha1-alpha2 domain

<400>  9

Ala Ala Ala Glu Pro His Lys Leu Ala Phe Asn Phe Asn Leu Glu Ile 
1               5                   10                  15      


Asn Gly Ser Asp Thr His Ser Thr Val Asp Val Tyr Leu Asp Asp Ser 
            20                  25                  30          


Gln Ile Ile Thr Phe Asp Gly Lys Asp Ile Arg Pro Thr Ile Pro Phe 
        35                  40                  45              


Met Ile Gly Asp Glu Ile Phe Leu Pro Phe Tyr Lys Asn Val Phe Ser 
    50                  55                  60                  


Glu Phe Phe Ser Leu Phe Arg Arg Val Pro Thr Ser Thr Pro Tyr Glu 
65                  70                  75                  80  


Asp Leu Thr Tyr Phe Tyr Glu Cys Asp Tyr Thr Asp Asn Lys Ser Thr 
                85                  90                  95      


Phe Asp Gln Phe Tyr Leu Tyr Asn Gly Glu Glu Tyr Thr Val Lys Thr 
            100                 105                 110         


Gln Glu Ala Thr Asn Lys Asn Met Trp Leu Thr Thr Ser Glu Phe Arg 
        115                 120                 125             


Leu Lys Lys Trp Phe Asp Gly Glu Asp Cys Ile Met His Leu Arg Ser 
    130                 135                 140                 


Leu Val Arg Lys Met Glu Asp Ser Lys Arg Arg Thr Val Pro Pro Met 
145                 150                 155                 160 


Val 
    


<210>  10
<211>  543
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding MICA alpha1-alpha2 domain

<400>  10
gagccccaca gtcttcgtta taacctcacg gtgctgtcct gggatggatc tgtgcagtca       60

gggtttctca ctgaggtaca tctggatggt cagcccttcc tgcgctgtga caggcagaaa      120

tgcagggcaa agccccaggg acagtgggca gaagatgtcc tgggaaataa gacatgggac      180

agagagacca gagacttgac agggaacgga aaggacctca ggatgaccct ggctcatatc      240

aaggaccaga aagaaggctt gcattccctc caggagatta gggtctgtga gatccatgaa      300

gacaacagca ccaggagctc ccagcatttc tactacgatg gggagctctt cctctcccaa      360

aacctggaga ctaaggaatg gacaatgccc cagtcctcca gagctcagac cttggccatg      420

aacgtcagga atttcttgaa ggaagatgcc atgaagacca agacacacta tcacgctatg      480

catgcagact gcctgcagga actacggcga tatctaaaat ccggcgtagt cctgaggaga      540

aca                                                                    543


<210>  11
<211>  561
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP1 alpha1-alpha2 domain

<400>  11
gctgctgagc cccactgtct ctgctacgac tttattataa ctcctaagtc aagaccagag       60

cctcagtggt gcgaagtaca aggtttggtt gacgaaaggc ctttccttca ctacgattgt      120

gtgaaccata aggcaaaggc tttcgccagc ctgggtaaga aggtaaacgt tactaagacg      180

tgggaggagc agacggaaac cctccgtgat gtggttgact ttcttaaggg tcagctcctc      240

gatatccaag tggagaattt aatccctatc gaaccgctca ctctgcaggc cagaatgtca      300

tgcgaacatg aagcacacgg tcatggaaga ggtagttggc aatttttatt taacggtcaa      360

aaattcctgc tgttcgactc aaacaaccgc aaatggactg cgctgcaccc tggagctaag      420

aagatgactg aaaaatggga gaagaacaga gacgttacca tgttcttcca gaagatttcc      480

ctgggagatt gtaagatgtg gttagaggag ttcttaatgt actgggaaca gatgctggac      540

cccacaaaac cccccatggt g                                                561


<210>  12
<211>  567
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2 alpha1-alpha2 domain

<400>  12
gctgctgagc cccatagtct gtgttacgac atcacagtta ttcccaagtt caggcccgga       60

ccgcgctggt gtgccgtgca aggacaagtc gacgaaaaaa cctttcttca ttacgattgc      120

ggaaataaga ctgtaacgcc agtctctcct ttaggtaaga agttaaacgt cactacggcg      180

tggaaggcac aaaaccccgt cctgcgcgag gtcgtcgaca tcctgactga acaattgcgc      240

gacatccagc tcgagaatta cactccaaag gagcctctta ccctgcaggc tagaatgtct      300

tgcgagcaaa aggcagaggg ccactcctcc ggcagctggc agttcagttt cgacggacaa      360

atctttctgt tattcgattc agagaagaga atgtggacta cagttcaccc cggtgcccgt      420

aaaatgaagg agaagtggga aaacgacaaa gtggtggcga tgtcattcca ctatttctcg      480

atgggagact gcatcggttg gctggaagat ttcctcatgg gtatggactc cactttggag      540

ccatcggctg gtgccccccc catggtg                                          567


<210>  13
<211>  561
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP3 alpha1-alpha2 domain

<400>  13
gctgctgagc cccacagctt gtggtacaac ttcaccatta tccacttgcc gagacatggc       60

cagcagtggt gcgaagtgca atcgcaagtc gaccaaaaaa acttcttatc atacgactgc      120

ggcagcgata aggtcttatc tatgggtcat ttggaggaac agctctacgc gaccgacgcc      180

tggggtaaac agctcgagat gctccgtgag gttggacaga ggctgagact ggaactggct      240

gacactgagc tggaagattt cacacctagt ggtccactca cattgcaagt acgcatgagc      300

tgcgagtgtg aggccgatgg atacattagg ggcagctggc agtttagctt cgacggaagg      360

aaattcctgc tcttcgacag taacaatagg aagtggactg ttgtgcatgc tggtgcgcgc      420

agaatgaagg aaaagtggga gaaagatagc ggcctgacga ccttcttcaa gatggtgtct      480

atgcgtgact gtaagagctg gctcagagat ttcctcatgc atcgcaagaa gaggttagaa      540

cctaccgctc cccccatggt g                                                561


<210>  14
<211>  561
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP4 alpha1-alpha2 domain

<400>  14
gctgctgagc cccactctct ttgcttcaac ttcaccatta aatccctgag caggcctggt       60

cagccgtggt gtgaggcgca ggtctttctt aacaagaatc tcttcctcca atacaactct      120

gataacaaca tggtaaagcc actgggtctc ctgggtaaaa aagtctatgc tacgagcact      180

tggggagaac tcacccagac tcttggcgag gtaggaagag acctgcgcat gctcctctgc      240

gatataaagc cccaaattaa gaccagtgat ccgtccactt tacaagtcga aatgttctgc      300

caaagggagg ctgaacgctg caccggagcc tcttggcagt tcgcgaccaa tggcgaaaag      360

tccctcttgt tcgatgccat gaatatgacc tggaccgtga tcaatcatga ggcctctaag      420

atcaaggaga cgtggaaaaa ggaccgcggc cttgaaaagt actttaggaa gttgtctaaa      480

ggagactgcg accattggtt acgcgagttc ctcggccatt gggaagcgat gcccgagcca      540

acggttagcc cccccatggt g                                                561


<210>  15
<211>  567
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP6 alpha1-alpha2 domain

<400>  15
gctgctgagc cccactcctt atgctatgat atcaccgtga ttccaaagtt ccgaccagga       60

ccccgatggt gcgccgtaca gggacaggtc gacgaaaaga cttttttaca ttacgactgc      120

ggtaacaaga cagtcacacc ggtaagtcct ttgggaaaaa agttaaacgt aaccactgct      180

tggaaggccc agaaccccgt ccttcgagaa gtagtggata ttttgactga acagctgctt      240

gacatccagc tggaaaacta cacacccaaa gagcccctga ctcttcaagc gcgtatgtcg      300

tgtgagcaaa aggccgaagg acacagctcc ggatcctggc agttcagtat cgacggtcag      360

accttcctcc tcttcgattc agaaaagcgc atgtggacta ctgtgcaccc cggcgctcgt      420

aagatgaagg aaaagtggga gaatgataag gacgttgcca tgagttttca ttacattagt      480

atgggagatt gcatcggttg gctggaagac ttcctgatgg gtatggatag tacccttgaa      540

cctagtgccg gagctccccc catggtg                                          567


<210>  16
<211>  483
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding OMCP alpha1-alpha2 domain

<400>  16
gctgctgctg agccccacaa gcttgcgttc aacttcaatc tggaaataaa cggttcagat       60

acccattcaa ccgtggacgt ttatttagac gattcgcaga taatcacctt tgacggcaag      120

gacatccgcc caactatccc gttcatgata ggtgacgaaa tcttccttcc tttttataag      180

aatgtgttct ctgagttctt cagtttgttc cgccgcgtcc ctacctcaac cccctacgaa      240

gacttgactt atttctatga atgcgactac accgacaaca aatctacatt cgatcaattc      300

tacctgtaca acggtgaaga gtacaccgtg aagactcaag aggctactaa caagaacatg      360

tggctgacca cttccgagtt cagactgaag aagtggttcg acggcgagga ctgtatcatg      420

caccttagaa gtttagtgag gaaaatggaa gatagcaaga gaagaacagt gccccccatg      480

gtg                                                                    483


<210>  17
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide natural NKG2D ectodomain

<400>  17

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  18
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152A ectodomain

<400>  18

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  19
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y199A ectodomain

<400>  19

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Ala Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  20
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152A/Y199A ectodomain

<400>  20

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Ala Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  21
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y199F eNKG2D1 ectodomain

<400>  21

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  22
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152S eNKG2D2 ectodomain

<400>  22

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ser His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  23
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152T eNKG2D3 ectodomain

<400>  23

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Thr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  24
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152V eNKG2D4 ectodomain

<400>  24

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Val His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  25
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152A/Y199F eNKG2D5 
       ectodomain

<400>  25

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  26
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152L/Y199F eNKG2D6 
       ectodomain

<400>  26

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Leu His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  27
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152S/Y199F eNKG2D7 
       ectodomain

<400>  27

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ser His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  28
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152T/Y199F eNKG2D8 
       ectodomain

<400>  28

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Thr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  29
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152V/Y199F eNKG2D9 
       ectodomain

<400>  29

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Val His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  30
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y199D eNKG2D10 ectodomain

<400>  30

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Asp Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  31
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y199E eNKG2D11 ectodomain

<400>  31

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Glu Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  32
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152D/Y199D eNKG2D12 
       ectodomain

<400>  32

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Asp His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Asp Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  33
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152E/Y199E eNKG2D13 
       ectodomain

<400>  33

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Glu His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Glu Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  34
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152L eNKG2D14 ectodomain

<400>  34

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Leu His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  35
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide non-natural NKG2D Y152F/Y199F eNKG2D15 
       ectodomain

<400>  35

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Phe His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 


<210>  36
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide MHCI signal sequence

<400>  36

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala 
            20              


<210>  37
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding MHCI signal sequence

<400>  37
atgggccttg gcccagtgtt tctgctgttg gcaggcattt tcccttttgc tccgcccggc       60

gccgcagcc                                                               69


<210>  38
<211>  237
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc with IEGR linker

<400>  38

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg 
225                 230                 235         


<210>  39
<211>  711
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc with IEGR linker

<400>  39
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg c               711


<210>  40
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D fusion

<400>  40

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  41
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152A fusion

<400>  41

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  42
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y199A ectodomain

<400>  42

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Ala Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  43
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152A/Y199A ectodomain

<400>  43

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Ala Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  44
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y199F eNKG2D1 fusion

<400>  44

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  45
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152S eNKG2D2 fusion

<400>  45

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  46
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152T eNKG2D3 fusion

<400>  46

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Thr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  47
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152V eNKG2D4 fusion

<400>  47

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Val His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  48
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152A/Y199F eNKG2D5 fusion

<400>  48

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  49
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152L/Y199F eNKG2D6 fusion

<400>  49

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Leu His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  50
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152S/Y199F eNKG2D7 fusion

<400>  50

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Ser His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  51
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152T/Y199F eNKG2D8 fusion

<400>  51

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Thr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  52
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152V/Y199F eNKG2D9 fusion

<400>  52

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Val His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  53
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y199D eNKG2D10 fusion

<400>  53

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Asp Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  54
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y199E eNKG2D11 fusion

<400>  54

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Glu Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  55
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152D/Y199D eNKG2D12 fusion

<400>  55

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Asp His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Asp Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  56
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152E/Y199E eNKG2D13 fusion

<400>  56

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Glu His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Glu Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  57
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152L eNKG2D14 fusion

<400>  57

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Leu His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  58
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 Fc-NKG2D Y152F/Y199F eNKG2D15 fusion

<400>  58

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Leu Asn 
225                 230                 235                 240 


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                245                 250                 255     


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            260                 265                 270         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        275                 280                 285             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    290                 295                 300                 


Leu Leu Lys Leu Val Lys Ser Phe His Trp Met Gly Leu Val His Ile 
305                 310                 315                 320 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                325                 330                 335     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            340                 345                 350         


Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        355                 360                 365             


Tyr Ile Cys Met Gln Arg Thr Val 
    370                 375     


<210>  59
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D fusion

<400>  59
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  60
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y152A 
       fusion

<400>  60
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagctcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  61
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y199A 
       ectodomain

<400>  61
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcataccatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcgctata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  62
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152A/Y199A ectodomain

<400>  62
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagctcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcgctata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  63
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y199F 
       eNKG2D1 fusion

<400>  63
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcataccatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  64
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y152S 
       eNKG2D2 fusion

<400>  64
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcataccatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  65
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y152T 
       eNKG2D3 fusion

<400>  65
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcaactcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  66
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y152V 
       eNKG2D4 fusion

<400>  66
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagtgcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  67
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152A/Y199F eNKG2D5 fusion

<400>  67
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagctcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  68
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152L/Y199F eNKG2D6 fusion

<400>  68
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcactgcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  69
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152S/Y199F eNKG2D7 fusion

<400>  69
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcaagtcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  70
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152T/Y199F eNKG2D8 fusion

<400>  70
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcaactcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  71
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152V/Y199F eNKG2D9 fusion

<400>  71
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagtgcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  72
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y199D 
       eNKG2D10 fusion

<400>  72
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcgatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  73
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y199E 
       eNKG2D11 fusion

<400>  73
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcataccatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcgagata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  74
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152D/Y199D eNKG2D12 fusion

<400>  74
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagatcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcgatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  75
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152E/Y199E eNKG2D13 fusion

<400>  75
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcagagcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcgagata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  76
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D Y152L 
       eNKG2D14 fusion

<400>  76
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcactgcatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  77
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human IgG1 Fc-NKG2D 
       Y152F/Y199F eNKG2D15 fusion

<400>  77
atggacccga aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gatgtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacaact cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cgggacgagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tggattccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaaga tcgaaggacg cttcttaaac      720

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      780

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      840

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      900

gaggaccagg atttacttaa actggtgaag tcattccatt ggatgggact agtacacatt      960

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca     1020

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggcttcata     1080

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtg                  1128


<210>  78
<211>  181
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide MICwed alpha1-alpha2

<400>  78

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Glu Thr Asp Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr 
            180     


<210>  79
<211>  543
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding MICwed alpha1-alpha2

<400>  79
gagcctcaca gcctccggta taatttgact gtactctctt gggatggctc cgtgcagtcc       60

ggctttctga ctgaagttca tctcgacggt caacctttcc tgcgctgcga ccgacaaaaa      120

tgccgcgcca agccccaagg gcagtgggcc gaagatgtac tgggaaacaa gacctgggac      180

cgggagacac gagacctgac aggctggggc aaggacttgc gcatgacact cgcccatatc      240

aaggaccaga aggaaggatt gcactctttg caagagattc gcgtgtgtga aatccacgag      300

gacaattcaa cgaggagctc ccagcacttc tattacgatg gagaactctt cttgtcacag      360

aacttggaaa ccaaggaatg gactatgcct cagagctctc gggcacagac tctcgctatg      420

aacgttagaa acttccttaa ggaggatgct atggagaccg atactcacta ccacgccatg      480

cacgccgact gcctccagga actgcggaga tatctgaagt ccggcgtggt tttgagaaga      540

acc                                                                    543


<210>  80
<211>  181
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide MIC25 alpha1-alpha2

<400>  80

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Leu Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Glu Thr Asp Thr His Tyr His Ala Met 
145                 150                 155                 160 


Arg Ala Asp Cys Leu Ser Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr 
            180     


<210>  81
<211>  543
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding MIC25 alpha1-alpha2

<400>  81
gagcctcaca gcctccggta taatttgact gtactctctt gggatggctc cgtgcagtcc       60

ggctttctga ctgaagttca tctcgacggt caacctttcc tgcgctgcga ccgacaaaaa      120

tgccgcgcca agccccaagg gcagtgggcc gaagatgtac tgggaaacaa gacctgggac      180

cgggagacac gagacctgac aggctggggc aaggacttgc gcatgacact cgcccatatc      240

aaggaccaga aggaaggatt gcactctttg caagagattc gcgtgtgtga aatccacgag      300

gacaattcaa cgaggagctc ccagcacttc tattacgatg gagaactctt cttgtcacag      360

aacttggaaa ccctcgaatg gactatgcct cagagctctc gggcacagac tctcgctatg      420

aacgttagaa acttccttaa ggaggatgct atggagaccg atactcacta ccacgccatg      480

cgcgccgact gcctctctga actgcggaga tatctgaagt ccggcgtggt tttgagaaga      540

acc                                                                    543


<210>  82
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human IgG1 heavy chain CH1-CH2-CH3 D265A/N297A

<400>  82

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  83
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human IgG1 heavy chain CH1-CH2-CH3 D265A/N297A

<400>  83
gcgtcgacca agggcccgtc agtgttcccg ctggccccgt catccaagtc cacgtctggg       60

ggcacagcag ccctgggatg cttggtcaag gactacttcc ccgagcccgt gactgtgtcc      120

tggaactccg gagcactgac ctccggagtg cacacctttc ccgcggtgct gcagtcctcc      180

ggactgtact ccctgtcgtc ggtcgtgacc gtgccgagct cctcgctcgg aacccagacc      240

tacatctgca acgtgaacca caagccctcg aacaccaaag tggacaagaa ggtcgagccc      300

aaaagctgcg acaagactca cacttgtccg ccgtgccccg cccccgaact gctgggtggc      360

ccctccgtgt tcctgttccc gcctaagcct aaggacaccc ttatgatcag ccgcacccct      420

gaagtgacct gtgtcgtcgt ggcagtgtca cacgaggacc cggaggtcaa gttcaattgg      480

tacgtggacg gcgtggaagt gcataacgca aagaccaagc ctcgggagga acagtacgcc      540

tcgacctacc gcgtggtgtc agtcctgact gtgctgcacc aggactggct gaacgggaag      600

gagtacaagt gcaaagtgtc gaacaaggcc ctgccggctc caattgaaaa gaccatcagc      660

aaggccaagg gccagccaag ggaaccacag gtgtacaccc tccctccttc ccgggacgag      720

ctgaccaaaa accaagtgtc cctgacttgc cttgtgaagg ggttctaccc ttctgacatt      780

gccgtcgaat gggaatcgaa cggacagcct gaaaacaact ataagactac cccgcccgtg      840

ctggattccg acggaagctt cttcctgtac tccaagctga ccgtggacaa gtcgagatgg      900

cagcagggaa atgtgttcag ctgctccgtg atgcatgagg cgctgcacaa ccactacacc      960

cagaagtcac tgagcctctc ccccggaaag                                       990


<210>  84
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide human kappa light chain

<400>  84

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  85
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding human kappa light chain

<400>  85
agaaccgtgg ccgccccgag cgtgttcatt ttccctccct ccgacgagca gttgaaatcg       60

ggcaccgcta gcgtggtctg ccttctcaac aatttctatc cacgggaagc caaagtgcag      120

tggaaggtcg acaacgcgct ccaatccggg aactcacagg aatccgtgac tgagcaggat      180

tccaaggact cgacctactc cctgtcatcc acgctgaccc tgagcaaggc agactacgag      240

aagcacaagg tctacgcctg cgaagtgaca caccagggac tgtccagccc cgtgaccaag      300

agcttcaaca gaggagaatg c                                                321


<210>  86
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab VH

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  87
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab VH

<400>  87
gaagtccaat tggtcgaatc aggcggtgga ctcgtgcaac ctggaggttc gttacgctta       60

tcatgtgctg caagtggatt taatattaaa gatacctaca tccactgggt acgtcaagct      120

cccggcaagg gtctcgagtg ggtcgcacgc atttacccca ccaacggata cacgcgctac      180

gccgattcag tgaagggacg tttcacaatc tctgctgata ctagcaaaaa taccgcatac      240

ctccagatga actctcttag ggccgaggac acagctgtgt actactgtag ccgttgggga      300

ggagacggtt tttacgcaat ggattactgg ggccaaggaa ccctggtcac agtttcatcg      360


<210>  88
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab VL

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  89
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab VL

<400>  89
gatatccaaa tgactcaatc accatcttca ctctccgcga gcgtgggtga tcgggtcacc       60

atcacatgta gggcgagcca agatgtgaat accgccgtcg cgtggtatca acaaaagccg      120

ggaaaagcac caaaactgct tatatactct gcatccttcc tgtactctgg ggtgccaagc      180

cggttctccg gtagtagatc tggtactgac tttacactca ctatcagcag tctgcaacct      240

gaggactttg cgacatacta ttgccagcag cactacacaa ccccacctac atttggtcag      300

gggacaaagg tggagatcaa g                                                321


<210>  90
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab VH

<400>  90

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala 
        115                 120     


<210>  91
<211>  363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab VH

<400>  91
caagttcagc ttcagcagcc gggggctgag ttggtgaaac ccggggccag tgtgaagatg       60

agctgtaaag cgagcggcta caccttcact tcttataata tgcattgggt taagcaaacg      120

ccaggaaggg ggctggagtg gatcggcgct atttacccag gtaacggtga cacatcatat      180

aaccaaaagt ttaagggaaa ggcaaccctc acagcggaca agagtagctc aaccgcatac      240

atgcaactgt caagccttac ctccgaagac agcgcagtgt actactgcgc cagaagcacc      300

tactatgggg gtgattggta cttcaacgtc tggggggctg gcaccacagt gactgtaagc      360

gca                                                                    363


<210>  92
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab VL

<400>  92

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  93
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab VL

<400>  93
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaag                                                    318


<210>  94
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab heavy chain

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  95
<211>  1350
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab heavy chain

<400>  95
gaagtccaat tggtcgaatc aggcggtgga ctcgtgcaac ctggaggttc gttacgctta       60

tcatgtgctg caagtggatt taatattaaa gatacctaca tccactgggt acgtcaagct      120

cccggcaagg gtctcgagtg ggtcgcacgc atttacccca ccaacggata cacgcgctac      180

gccgattcag tgaagggacg tttcacaatc tctgctgata ctagcaaaaa taccgcatac      240

ctccagatga actctcttag ggccgaggac acagctgtgt actactgtag ccgttgggga      300

ggagacggtt tttacgcaat ggattactgg ggccaaggaa ccctggtcac agtttcatcg      360

gcgtcgacca agggcccgtc agtgttcccg ctggccccgt catccaagtc cacgtctggg      420

ggcacagcag ccctgggatg cttggtcaag gactacttcc ccgagcccgt gactgtgtcc      480

tggaactccg gagcactgac ctccggagtg cacacctttc ccgcggtgct gcagtcctcc      540

ggactgtact ccctgtcgtc ggtcgtgacc gtgccgagct cctcgctcgg aacccagacc      600

tacatctgca acgtgaacca caagccctcg aacaccaaag tggacaagaa ggtcgagccc      660

aaaagctgcg acaagactca cacttgtccg ccgtgccccg cccccgaact gctgggtggc      720

ccctccgtgt tcctgttccc gcctaagcct aaggacaccc ttatgatcag ccgcacccct      780

gaagtgacct gtgtcgtcgt ggatgtgtca cacgaggacc cggaggtcaa gttcaattgg      840

tacgtggacg gcgtggaagt gcataacgca aagaccaagc ctcgggagga acagtacaac      900

tcgacctacc gcgtggtgtc agtcctgact gtgctgcacc aggactggct gaacgggaag      960

gagtacaagt gcaaagtgtc gaacaaggcc ctgccggctc caattgaaaa gaccatcagc     1020

aaggccaagg gccagccaag ggaaccacag gtgtacaccc tccctccttc ccgggacgag     1080

ctgaccaaaa accaagtgtc cctgacttgc cttgtgaagg ggttctaccc ttctgacatt     1140

gccgtcgaat gggaatcgaa cggacagcct gaaaacaact ataagactac cccgcccgtg     1200

ctggattccg acggaagctt cttcctgtac tccaagctga ccgtggacaa gtcgagatgg     1260

cagcagggaa atgtgttcag ctgctccgtg atgcatgagg cgctgcacaa ccactacacc     1320

cagaagtcac tgagcctctc ccccggaaag                                      1350


<210>  96
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab light chain

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  97
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab light chain

<400>  97
gatatccaaa tgactcaatc accatcttca ctctccgcga gcgtgggtga tcgggtcacc       60

atcacatgta gggcgagcca agatgtgaat accgccgtcg cgtggtatca acaaaagccg      120

ggaaaagcac caaaactgct tatatactct gcatccttcc tgtactctgg ggtgccaagc      180

cggttctccg gtagtagatc tggtactgac tttacactca ctatcagcag tctgcaacct      240

gaggactttg cgacatacta ttgccagcag cactacacaa ccccacctac atttggtcag      300

gggacaaagg tggagatcaa gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgct ag                         642


<210>  98
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab heavy chain

<400>  98

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  99
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab heavy chain

<400>  99
caagttcagc ttcagcagcc gggggctgag ttggtgaaac ccggggccag tgtgaagatg       60

agctgtaaag cgagcggcta caccttcact tcttataata tgcattgggt taagcaaacg      120

ccaggaaggg ggctggagtg gatcggcgct atttacccag gtaacggtga cacatcatat      180

aaccaaaagt ttaagggaaa ggcaaccctc acagcggaca agagtagctc aaccgcatac      240

atgcaactgt caagccttac ctccgaagac agcgcagtgt actactgcgc cagaagcacc      300

tactatgggg gtgattggta cttcaacgtc tggggggctg gcaccacagt gactgtaagc      360

gcagcgtcga ccaagggccc gtcagtgttc ccgctggccc cgtcatccaa gtccacgtct      420

gggggcacag cagccctggg atgcttggtc aaggactact tccccgagcc cgtgactgtg      480

tcctggaact ccggagcact gacctccgga gtgcacacct ttcccgcggt gctgcagtcc      540

tccggactgt actccctgtc gtcggtcgtg accgtgccga gctcctcgct cggaacccag      600

acctacatct gcaacgtgaa ccacaagccc tcgaacacca aagtggacaa gaaggtcgag      660

cccaaaagct gcgacaagac tcacacttgt ccgccgtgcc ccgcccccga actgctgggt      720

ggcccctccg tgttcctgtt cccgcctaag cctaaggaca cccttatgat cagccgcacc      780

cctgaagtga cctgtgtcgt cgtggatgtg tcacacgagg acccggaggt caagttcaat      840

tggtacgtgg acggcgtgga agtgcataac gcaaagacca agcctcggga ggaacagtac      900

aactcgacct accgcgtggt gtcagtcctg actgtgctgc accaggactg gctgaacggg      960

aaggagtaca agtgcaaagt gtcgaacaag gccctgccgg ctccaattga aaagaccatc     1020

agcaaggcca agggccagcc aagggaacca caggtgtaca ccctccctcc ttcccgggac     1080

gagctgacca aaaaccaagt gtccctgact tgccttgtga aggggttcta cccttctgac     1140

attgccgtcg aatgggaatc gaacggacag cctgaaaaca actataagac taccccgccc     1200

gtgctggatt ccgacggaag cttcttcctg tactccaagc tgaccgtgga caagtcgaga     1260

tggcagcagg gaaatgtgtt cagctgctcc gtgatgcatg aggcgctgca caaccactac     1320

acccagaagt cactgagcct ctcccccgga aag                                  1353


<210>  100
<211>  212
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab light chain

<400>  100

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  101
<211>  639
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab light chain

<400>  101
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagac cgtggccgcc ccgagcgtgt tcattttccc tccctccgac      360

gagcagttga aatcgggcac cgctagcgtg gtctgccttc tcaacaattt ctatccacgg      420

gaagccaaag tgcagtggaa ggtcgacaac gcgctccaat ccgggaactc acaggaatcc      480

gtgactgagc aggattccaa ggactcgacc tactccctgt catccacgct gaccctgagc      540

aaggcagact acgagaagca caaggtctac gcctgcgaag tgacacacca gggactgtcc      600

agccccgtga ccaagagctt caacagagga gaatgctag                             639


<210>  102
<211>  634
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab HC_MICwed

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Gly Gly Gly Ser Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val 
    450                 455                 460                 


Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His 
465                 470                 475                 480 


Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala 
                485                 490                 495     


Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp 
            500                 505                 510         


Asp Arg Glu Thr Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met 
        515                 520                 525             


Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln 
    530                 535                 540                 


Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser 
545                 550                 555                 560 


Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu 
                565                 570                 575     


Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala 
            580                 585                 590         


Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Glu Thr Asp Thr 
        595                 600                 605             


His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr 
    610                 615                 620                 


Leu Lys Ser Gly Val Val Leu Arg Arg Thr 
625                 630                 


<210>  103
<211>  1902
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab HC_MICwed

<400>  103
gaagtccaat tggtcgaatc aggcggtgga ctcgtgcaac ctggaggttc gttacgctta       60

tcatgtgctg caagtggatt taatattaaa gatacctaca tccactgggt acgtcaagct      120

cccggcaagg gtctcgagtg ggtcgcacgc atttacccca ccaacggata cacgcgctac      180

gccgattcag tgaagggacg tttcacaatc tctgctgata ctagcaaaaa taccgcatac      240

ctccagatga actctcttag ggccgaggac acagctgtgt actactgtag ccgttgggga      300

ggagacggtt tttacgcaat ggattactgg ggccaaggaa ccctggtcac agtttcatcg      360

gcgtcgacca agggcccgtc agtgttcccg ctggccccgt catccaagtc cacgtctggg      420

ggcacagcag ccctgggatg cttggtcaag gactacttcc ccgagcccgt gactgtgtcc      480

tggaactccg gagcactgac ctccggagtg cacacctttc ccgcggtgct gcagtcctcc      540

ggactgtact ccctgtcgtc ggtcgtgacc gtgccgagct cctcgctcgg aacccagacc      600

tacatctgca acgtgaacca caagccctcg aacaccaaag tggacaagaa ggtcgagccc      660

aaaagctgcg acaagactca cacttgtccg ccgtgccccg cccccgaact gctgggtggc      720

ccctccgtgt tcctgttccc gcctaagcct aaggacaccc ttatgatcag ccgcacccct      780

gaagtgacct gtgtcgtcgt ggcagtgtca cacgaggacc cggaggtcaa gttcaattgg      840

tacgtggacg gcgtggaagt gcataacgca aagaccaagc ctcgggagga acagtacgcc      900

tcgacctacc gcgtggtgtc agtcctgact gtgctgcacc aggactggct gaacgggaag      960

gagtacaagt gcaaagtgtc gaacaaggcc ctgccggctc caattgaaaa gaccatcagc     1020

aaggccaagg gccagccaag ggaaccacag gtgtacaccc tccctccttc ccgggacgag     1080

ctgaccaaaa accaagtgtc cctgacttgc cttgtgaagg ggttctaccc ttctgacatt     1140

gccgtcgaat gggaatcgaa cggacagcct gaaaacaact ataagactac cccgcccgtg     1200

ctggattccg acggaagctt cttcctgtac tccaagctga ccgtggacaa gtcgagatgg     1260

cagcagggaa atgtgttcag ctgctccgtg atgcatgagg cgctgcacaa ccactacacc     1320

cagaagtcac tgagcctctc ccccggagga ggtggcagcg agcctcacag cctccggtat     1380

aatttgactg tactctcttg ggatggctcc gtgcagtccg gctttctgac tgaagttcat     1440

ctcgacggtc aacctttcct gcgctgcgac cgacaaaaat gccgcgccaa gccccaaggg     1500

cagtgggccg aagatgtact gggaaacaag acctgggacc gggagacacg agacctgaca     1560

ggctggggca aggacttgcg catgacactc gcccatatca aggaccagaa ggaaggattg     1620

cactctttgc aagagattcg cgtgtgtgaa atccacgagg acaattcaac gaggagctcc     1680

cagcacttct attacgatgg agaactcttc ttgtcacaga acttggaaac caaggaatgg     1740

actatgcctc agagctctcg ggcacagact ctcgctatga acgttagaaa cttccttaag     1800

gaggatgcta tggagaccga tactcactac cacgccatgc acgccgactg cctccaggaa     1860

ctgcggagat atctgaagtc cggcgtggtt ttgagaagaa cc                        1902


<210>  104
<211>  634
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab HC_MIC25

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Gly Gly Gly Ser Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val 
    450                 455                 460                 


Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His 
465                 470                 475                 480 


Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala 
                485                 490                 495     


Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp 
            500                 505                 510         


Asp Arg Glu Thr Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met 
        515                 520                 525             


Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln 
    530                 535                 540                 


Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser 
545                 550                 555                 560 


Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu 
                565                 570                 575     


Thr Leu Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala 
            580                 585                 590         


Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Glu Thr Asp Thr 
        595                 600                 605             


His Tyr His Ala Met Arg Ala Asp Cys Leu Ser Glu Leu Arg Arg Tyr 
    610                 615                 620                 


Leu Lys Ser Gly Val Val Leu Arg Arg Thr 
625                 630                 


<210>  105
<211>  1902
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab HC_MIC25

<400>  105
gaagtccaat tggtcgaatc aggcggtgga ctcgtgcaac ctggaggttc gttacgctta       60

tcatgtgctg caagtggatt taatattaaa gatacctaca tccactgggt acgtcaagct      120

cccggcaagg gtctcgagtg ggtcgcacgc atttacccca ccaacggata cacgcgctac      180

gccgattcag tgaagggacg tttcacaatc tctgctgata ctagcaaaaa taccgcatac      240

ctccagatga actctcttag ggccgaggac acagctgtgt actactgtag ccgttgggga      300

ggagacggtt tttacgcaat ggattactgg ggccaaggaa ccctggtcac agtttcatcg      360

gcgtcgacca agggcccgtc agtgttcccg ctggccccgt catccaagtc cacgtctggg      420

ggcacagcag ccctgggatg cttggtcaag gactacttcc ccgagcccgt gactgtgtcc      480

tggaactccg gagcactgac ctccggagtg cacacctttc ccgcggtgct gcagtcctcc      540

ggactgtact ccctgtcgtc ggtcgtgacc gtgccgagct cctcgctcgg aacccagacc      600

tacatctgca acgtgaacca caagccctcg aacaccaaag tggacaagaa ggtcgagccc      660

aaaagctgcg acaagactca cacttgtccg ccgtgccccg cccccgaact gctgggtggc      720

ccctccgtgt tcctgttccc gcctaagcct aaggacaccc ttatgatcag ccgcacccct      780

gaagtgacct gtgtcgtcgt ggcagtgtca cacgaggacc cggaggtcaa gttcaattgg      840

tacgtggacg gcgtggaagt gcataacgca aagaccaagc ctcgggagga acagtacgcc      900

tcgacctacc gcgtggtgtc agtcctgact gtgctgcacc aggactggct gaacgggaag      960

gagtacaagt gcaaagtgtc gaacaaggcc ctgccggctc caattgaaaa gaccatcagc     1020

aaggccaagg gccagccaag ggaaccacag gtgtacaccc tccctccttc ccgggacgag     1080

ctgaccaaaa accaagtgtc cctgacttgc cttgtgaagg ggttctaccc ttctgacatt     1140

gccgtcgaat gggaatcgaa cggacagcct gaaaacaact ataagactac cccgcccgtg     1200

ctggattccg acggaagctt cttcctgtac tccaagctga ccgtggacaa gtcgagatgg     1260

cagcagggaa atgtgttcag ctgctccgtg atgcatgagg cgctgcacaa ccactacacc     1320

cagaagtcac tgagcctctc ccccggagga ggtggcagcg agcctcacag cctccggtat     1380

aatttgactg tactctcttg ggatggctcc gtgcagtccg gctttctgac tgaagttcat     1440

ctcgacggtc aacctttcct gcgctgcgac cgacaaaaat gccgcgccaa gccccaaggg     1500

cagtgggccg aagatgtact gggaaacaag acctgggacc gggagacacg agacctgaca     1560

ggctggggca aggacttgcg catgacactc gcccatatca aggaccagaa ggaaggattg     1620

cactctttgc aagagattcg cgtgtgtgaa atccacgagg acaattcaac gaggagctcc     1680

cagcacttct attacgatgg agaactcttc ttgtcacaga acttggaaac cctcgaatgg     1740

actatgcctc agagctctcg ggcacagact ctcgctatga acgttagaaa cttccttaag     1800

gaggatgcta tggagaccga tactcactac cacgccatgc gcgccgactg cctctctgaa     1860

ctgcggagat atctgaagtc cggcgtggtt ttgagaagaa cc                        1902


<210>  106
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab LC_ULBP2.wt

<400>  106

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
225                 230                 235                 240 


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
                245                 250                 255     


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
            260                 265                 270         


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
        275                 280                 285             


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile 
    290                 295                 300                 


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
305                 310                 315                 320 


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
                325                 330                 335     


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
            340                 345                 350         


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
        355                 360                 365             


Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly 
    370                 375                 380                 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
385                 390                 395                 400 


Leu Glu Pro Ser 
                


<210>  107
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab LC_ULBP2.wt

<400>  107
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagcg gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgcg cacctacctc aagctctgga      660

ggaggtggca gcgagcccca tagtctgagc tacgacatca cagttattcc caagttcagg      720

cccggaccgc gctggtgtgc cgtgcaagga caagtcgacg aaaaaacctt tcttcattac      780

gattgcggaa ataagactgt aacgccagtc tctcctttag gtaagaagtt aaacgtcact      840

acggcgtgga aggcacaaaa ccccgtcctg cgcgaggtcg tcgacatcct gactgaacaa      900

ttgcgcgaca tccagctcga gaattacact ccaaaggagc ctcttaccct gcaggctaga      960

atgtcttgcg agcaaaaggc agagggccac tcctccggca gctggcagtt cagtttcgac     1020

ggacaaatct ttctgttatt cgattcagag aagagaatgt ggactacagt tcaccccggt     1080

gcccgtaaaa tgaaggagaa gtgggaaaac gacaaagtgg tggcgatgtc attccactat     1140

ttctcgatgg gagactgcat cggttggctg gaagatttcc tcatgggtat ggactccact     1200

ttggagccat cg                                                         1212


<210>  108
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULPB2 alpha1-alpha2 variant R80W

<400>  108

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser Ala Gly Ala Pro Pro Met Val 
            180                 185         


<210>  109
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULPB2 alpha1-alpha2 variant 
       R80W

<400>  109
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgatgtcat tccactattt ctcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540


<210>  110
<211>  513
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULPB2 alpha1-alpha2 variant 
       R80W NNK library


<220>
<221>  misc_feature
<222>  (457)..(458)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (460)..(461)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (463)..(464)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (466)..(467)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (469)..(470)
<223>  n is a, c, g, or t

<400>  110
gagccccata gcctcagcta tgacattacg gtgattccca aatttcgccc aggaccacgt       60

tggtgcgccg tccagggtca ggtagatgaa aagactttcc tgcattatga ttgcggcaat      120

aaaaccgtga cgccggtatc gccgttaggc aaaaaattga atgtcacgac agcgtggaaa      180

gcacagaacc cggtgttgcg cgaggtagtc gatattttga cggaacaact ctgggacatt      240

cagctcgaga attacacccc aaaagaaccg ctgacgctgc aagcgcgtat gtcgtgcgaa      300

caaaaagcag aaggtcactc tagcgggagt tggcagtttt ccttcgatgg gcagattttt      360

ctgctgtttg attcggagaa acgcatgtgg actacagtcc acccgggtgc ccggaaaatg      420

aaagagaagt gggagaatga taaagtggtg gccactnnkn nknnknnknn ktccatgggc      480

gattgcattg gctggttaga ggattttctc atg                                   513


<210>  111
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide, ULBP2 alpha1-alpha2 variant ULBP2.C

<400>  111

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Ile Leu Trp Gln Thr Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser 
            180 


<210>  112
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2 alpha1-alpha2 variant 
       ULBP2.C

<400>  112
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactattc tgtggcagac ttcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540


<210>  113
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide, ULBP2 alpha1-alpha2 variant ULBP2.R

<400>  113

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Leu Leu Trp Gly Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser 
            180 


<210>  114
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2 alpha1-alpha2 variant 
       ULBP2.R

<400>  114
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactttgt tgtgggggtg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540


<210>  115
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide, ULBP2 alpha1-alpha2 variant ULBP2.AA

<400>  115

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Met Phe Trp Ser Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser 
            180 


<210>  116
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2 alpha1-alpha2 variant 
       ULBP2.AA

<400>  116
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactatgt tttggagttg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540


<210>  117
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide, ULBP2 alpha1-alpha2 variant ULBP2.AB

<400>  117

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Leu Met Trp Gln Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser 
            180 


<210>  118
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2 alpha1-alpha2 variant 
       ULBP2.AB

<400>  118
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactctta tgtggcagtg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540


<210>  119
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab LC_ULBP2.C

<400>  119

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
225                 230                 235                 240 


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
                245                 250                 255     


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
            260                 265                 270         


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
        275                 280                 285             


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
    290                 295                 300                 


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
305                 310                 315                 320 


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
                325                 330                 335     


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
            340                 345                 350         


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
        355                 360                 365             


Glu Asn Asp Lys Val Val Ala Thr Ile Leu Trp Gln Thr Ser Met Gly 
    370                 375                 380                 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
385                 390                 395                 400 


Leu Glu Pro Ser 
                


<210>  120
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab LC_ULBP2.C

<400>  120
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagcg gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgcg cacctacctc aagctctgga      660

ggaggtggca gcgagcccca tagtctgagc tacgacatca cagttattcc caagttcagg      720

cccggaccgc gctggtgtgc cgtgcaagga caagtcgacg aaaaaacctt tcttcattac      780

gattgcggaa ataagactgt aacgccagtc tctcctttag gtaagaagtt aaacgtcact      840

acggcgtgga aggcacaaaa ccccgtcctg cgcgaggtcg tcgacatcct gactgaacaa      900

ttgtgggaca tccagctcga gaattacact ccaaaggagc ctcttaccct gcaggctaga      960

atgtcttgcg agcaaaaggc agagggccac tcctccggca gctggcagtt cagtttcgac     1020

ggacaaatct ttctgttatt cgattcagag aagagaatgt ggactacagt tcaccccggt     1080

gcccgtaaaa tgaaggagaa gtgggaaaac gacaaagtgg tggcgactat tctgtggcag     1140

acttcgatgg gagactgcat cggttggctg gaagatttcc tcatgggtat ggactccact     1200

ttggagccat cg                                                         1212


<210>  121
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab LC_ULBP2.R

<400>  121

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
225                 230                 235                 240 


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
                245                 250                 255     


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
            260                 265                 270         


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
        275                 280                 285             


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
    290                 295                 300                 


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
305                 310                 315                 320 


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
                325                 330                 335     


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
            340                 345                 350         


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
        355                 360                 365             


Glu Asn Asp Lys Val Val Ala Thr Leu Leu Trp Gly Trp Ser Met Gly 
    370                 375                 380                 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
385                 390                 395                 400 


Leu Glu Pro Ser 
                


<210>  122
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab LC_ULBP2.R

<400>  122
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagcg gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgcg cacctacctc aagctctgga      660

ggaggtggca gcgagcccca tagtctgagc tacgacatca cagttattcc caagttcagg      720

cccggaccgc gctggtgtgc cgtgcaagga caagtcgacg aaaaaacctt tcttcattac      780

gattgcggaa ataagactgt aacgccagtc tctcctttag gtaagaagtt aaacgtcact      840

acggcgtgga aggcacaaaa ccccgtcctg cgcgaggtcg tcgacatcct gactgaacaa      900

ttgtgggaca tccagctcga gaattacact ccaaaggagc ctcttaccct gcaggctaga      960

atgtcttgcg agcaaaaggc agagggccac tcctccggca gctggcagtt cagtttcgac     1020

ggacaaatct ttctgttatt cgattcagag aagagaatgt ggactacagt tcaccccggt     1080

gcccgtaaaa tgaaggagaa gtgggaaaac gacaaagtgg tggcgacttt gttgtggggg     1140

tggtcgatgg gagactgcat cggttggctg gaagatttcc tcatgggtat ggactccact     1200

ttggagccat cg                                                         1212


<210>  123
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab LC_ULBP2.AA

<400>  123

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
225                 230                 235                 240 


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
                245                 250                 255     


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
            260                 265                 270         


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
        275                 280                 285             


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
    290                 295                 300                 


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
305                 310                 315                 320 


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
                325                 330                 335     


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
            340                 345                 350         


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
        355                 360                 365             


Glu Asn Asp Lys Val Val Ala Thr Met Phe Trp Ser Trp Ser Met Gly 
    370                 375                 380                 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
385                 390                 395                 400 


Leu Glu Pro Ser 
                


<210>  124
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab LC_ULBP2.AA

<400>  124
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagcg gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgcg cacctacctc aagctctgga      660

ggaggtggca gcgagcccca tagtctgagc tacgacatca cagttattcc caagttcagg      720

cccggaccgc gctggtgtgc cgtgcaagga caagtcgacg aaaaaacctt tcttcattac      780

gattgcggaa ataagactgt aacgccagtc tctcctttag gtaagaagtt aaacgtcact      840

acggcgtgga aggcacaaaa ccccgtcctg cgcgaggtcg tcgacatcct gactgaacaa      900

ttgtgggaca tccagctcga gaattacact ccaaaggagc ctcttaccct gcaggctaga      960

atgtcttgcg agcaaaaggc agagggccac tcctccggca gctggcagtt cagtttcgac     1020

ggacaaatct ttctgttatt cgattcagag aagagaatgt ggactacagt tcaccccggt     1080

gcccgtaaaa tgaaggagaa gtgggaaaac gacaaagtgg tggcgactat gttttggagt     1140

tggtcgatgg gagactgcat cggttggctg gaagatttcc tcatgggtat ggactccact     1200

ttggagccat cg                                                         1212


<210>  125
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab LC_ULBP2.AB

<400>  125

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
225                 230                 235                 240 


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
                245                 250                 255     


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
            260                 265                 270         


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
        275                 280                 285             


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
    290                 295                 300                 


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
305                 310                 315                 320 


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
                325                 330                 335     


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
            340                 345                 350         


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
        355                 360                 365             


Glu Asn Asp Lys Val Val Ala Thr Leu Met Trp Gln Trp Ser Met Gly 
    370                 375                 380                 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
385                 390                 395                 400 


Leu Glu Pro Ser 
                


<210>  126
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab LC_ULBP2.AB

<400>  126
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagcg gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgcg cacctacctc aagctctgga      660

ggaggtggca gcgagcccca tagtctgagc tacgacatca cagttattcc caagttcagg      720

cccggaccgc gctggtgtgc cgtgcaagga caagtcgacg aaaaaacctt tcttcattac      780

gattgcggaa ataagactgt aacgccagtc tctcctttag gtaagaagtt aaacgtcact      840

acggcgtgga aggcacaaaa ccccgtcctg cgcgaggtcg tcgacatcct gactgaacaa      900

ttgtgggaca tccagctcga gaattacact ccaaaggagc ctcttaccct gcaggctaga      960

atgtcttgcg agcaaaaggc agagggccac tcctccggca gctggcagtt cagtttcgac     1020

ggacaaatct ttctgttatt cgattcagag aagagaatgt ggactacagt tcaccccggt     1080

gcccgtaaaa tgaaggagaa gtgggaaaac gacaaagtgg tggcgactct tatgtggcag     1140

tggtcgatgg gagactgcat cggttggctg gaagatttcc tcatgggtat ggactccact     1200

ttggagccat cg                                                         1212


<210>  127
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide, ULBP2 alpha1-alpha2 variant ULBP2.S3

<400>  127

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Lys Leu Tyr Leu Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser 
            180 


<210>  128
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2 alpha1-alpha2 variant 
       ULBP2.S3

<400>  128
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactaagc tttatctttg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540


<210>  129
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab LC_ULBP2.S3

<400>  129

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
225                 230                 235                 240 


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
                245                 250                 255     


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
            260                 265                 270         


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
        275                 280                 285             


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
    290                 295                 300                 


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
305                 310                 315                 320 


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
                325                 330                 335     


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
            340                 345                 350         


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
        355                 360                 365             


Glu Asn Asp Lys Val Val Ala Thr Lys Leu Tyr Leu Trp Ser Met Gly 
    370                 375                 380                 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
385                 390                 395                 400 


Leu Glu Pro Ser 
                


<210>  130
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab LC_ULBP2.S3

<400>  130
cagatcgtgt tgtcccaatc acccgcaatt ctctctgcga gcccagggga gaaggtgacc       60

atgacttgcc gcgcttcaag ttccgtatcc tacattcact ggttccagca gaagcccgga      120

agttccccta agccctggat ctatgctaca tccaatctgg caagcggtgt tcccgttaga      180

ttttccggaa gcgggtctgg aaccagttac agtctgacta tttccagggt cgaggccgaa      240

gatgcggcta cttattattg ccaacagtgg acctctaacc cacccacatt cggcggcggc      300

actaagttgg aaattaagcg gaccgtggcc gccccgagcg tgttcatttt ccctccctcc      360

gacgagcagt tgaaatcggg caccgctagc gtggtctgcc ttctcaacaa tttctatcca      420

cgggaagcca aagtgcagtg gaaggtcgac aacgcgctcc aatccgggaa ctcacaggaa      480

tccgtgactg agcaggattc caaggactcg acctactccc tgtcatccac gctgaccctg      540

agcaaggcag actacgagaa gcacaaggtc tacgcctgcg aagtgacaca ccagggactg      600

tccagccccg tgaccaagag cttcaacaga ggagaatgcg cacctacctc aagctctgga      660

ggaggtggca gcgagcccca tagtctgagc tacgacatca cagttattcc caagttcagg      720

cccggaccgc gctggtgtgc cgtgcaagga caagtcgacg aaaaaacctt tcttcattac      780

gattgcggaa ataagactgt aacgccagtc tctcctttag gtaagaagtt aaacgtcact      840

acggcgtgga aggcacaaaa ccccgtcctg cgcgaggtcg tcgacatcct gactgaacaa      900

ttgtgggaca tccagctcga gaattacact ccaaaggagc ctcttaccct gcaggctaga      960

atgtcttgcg agcaaaaggc agagggccac tcctccggca gctggcagtt cagtttcgac     1020

ggacaaatct ttctgttatt cgattcagag aagagaatgt ggactacagt tcaccccggt     1080

gcccgtaaaa tgaaggagaa gtgggaaaac gacaaagtgg tggcgactaa gctttatctt     1140

tggtcgatgg gagactgcat cggttggctg gaagatttcc tcatgggtat ggactccact     1200

ttggagccat cg                                                         1212


<210>  131
<211>  634
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide rituximab HC_ULBP2.R80W

<400>  131

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Ser Glu Pro His Ser Leu Ser Tyr Asp Ile Thr 
    450                 455                 460                 


Val Ile Pro Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly 
465                 470                 475                 480 


Gln Val Asp Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr 
                485                 490                 495     


Val Thr Pro Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala 
            500                 505                 510         


Trp Lys Ala Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr 
        515                 520                 525             


Glu Gln Leu Trp Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro 
    530                 535                 540                 


Leu Thr Leu Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His 
545                 550                 555                 560 


Ser Ser Gly Ser Trp Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu 
                565                 570                 575     


Phe Asp Ser Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg 
            580                 585                 590         


Lys Met Lys Glu Lys Trp Glu Asn Asp Lys Val Val Ala Met Ser Phe 
        595                 600                 605             


His Tyr Phe Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu 
    610                 615                 620                 


Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
625                 630                 


<210>  132
<211>  1902
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding rituximab HC_ULBP2.R80W

<400>  132
caagttcagc ttcagcagcc gggggctgag ttggtgaaac ccggggccag tgtgaagatg       60

agctgtaaag cgagcggcta caccttcact tcttataata tgcattgggt taagcaaacg      120

ccaggaaggg ggctggagtg gatcggcgct atttacccag gtaacggtga cacatcatat      180

aaccaaaagt ttaagggaaa ggcaaccctc acagcggaca agagtagctc aaccgcatac      240

atgcaactgt caagccttac ctccgaagac agcgcagtgt actactgcgc cagaagcacc      300

tactatgggg gtgattggta cttcaacgtc tggggggctg gcaccacagt gactgtaagc      360

gcagcgtcga ccaagggccc gtcagtgttc ccgctggccc cgtcatccaa gtccacgtct      420

gggggcacag cagccctggg atgcttggtc aaggactact tccccgagcc cgtgactgtg      480

tcctggaact ccggagcact gacctccgga gtgcacacct ttcccgcggt gctgcagtcc      540

tccggactgt actccctgtc gtcggtcgtg accgtgccga gctcctcgct cggaacccag      600

acctacatct gcaacgtgaa ccacaagccc tcgaacacca aagtggacaa gaaggtcgag      660

cccaaaagct gcgacaagac tcacacttgt ccgccgtgcc ccgcccccga actgctgggt      720

ggcccctccg tgttcctgtt cccgcctaag cctaaggaca cccttatgat cagccgcacc      780

cctgaagtga cctgtgtcgt cgtggcagtg tcacacgagg acccggaggt caagttcaat      840

tggtacgtgg acggcgtgga agtgcataac gcaaagacca agcctcggga ggaacagtac      900

gcctcgacct accgcgtggt gtcagtcctg actgtgctgc accaggactg gctgaacggg      960

aaggagtaca agtgcaaagt gtcgaacaag gccctgccgg ctccaattga aaagaccatc     1020

agcaaggcca agggccagcc aagggaacca caggtgtaca ccctccctcc ttcccgggac     1080

gagctgacca aaaaccaagt gtccctgact tgccttgtga aggggttcta cccttctgac     1140

attgccgtcg aatgggaatc gaacggacag cctgaaaaca actataagac taccccgccc     1200

gtgctggatt ccgacggaag cttcttcctg tactccaagc tgaccgtgga caagtcgaga     1260

tggcagcagg gaaatgtgtt cagctgctcc gtgatgcatg aggcgctgca caaccactac     1320

acccagaagt cactgagcct ctcccccgga ggaggtggca gcgagcccca tagtctgagc     1380

tacgacatca cagttattcc caagttcagg cccggaccgc gctggtgtgc cgtgcaagga     1440

caagtcgacg aaaaaacctt tcttcattac gattgcggaa ataagactgt aacgccagtc     1500

tctcctttag gtaagaagtt aaacgtcact acggcgtgga aggcacaaaa ccccgtcctg     1560

cgcgaggtcg tcgacatcct gactgaacaa ttgtgggaca tccagctcga gaattacact     1620

ccaaaggagc ctcttaccct gcaggctaga atgtcttgcg agcaaaaggc agagggccac     1680

tcctccggca gctggcagtt cagtttcgac ggacaaatct ttctgttatt cgattcagag     1740

aagagaatgt ggactacagt tcaccccggt gcccgtaaaa tgaaggagaa gtgggaaaac     1800

gacaaagtgg tggcgatgtc attccactat ttctcgatgg gagactgcat cggttggctg     1860

gaagatttcc tcatgggtat ggactccact ttggagccat cg                        1902


<210>  133
<211>  405
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide trastuzumab LC_ULBP2.R

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Pro Thr Ser Ser Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe 
225                 230                 235                 240 


Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys 
                245                 250                 255     


Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser 
            260                 265                 270         


Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn 
        275                 280                 285             


Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp 
    290                 295                 300                 


Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala 
305                 310                 315                 320 


Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp 
                325                 330                 335     


Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys 
            340                 345                 350         


Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys 
        355                 360                 365             


Trp Glu Asn Asp Lys Val Val Ala Thr Leu Leu Trp Gly Trp Ser Met 
    370                 375                 380                 


Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser 
385                 390                 395                 400 


Thr Leu Glu Pro Ser 
                405 


<210>  134
<211>  1215
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding trastuzumab LC_ULBP2.R

<400>  134
gatatccaaa tgactcaatc accatcttca ctctccgcga gcgtgggtga tcgggtcacc       60

atcacatgta gggcgagcca agatgtgaat accgccgtcg cgtggtatca acaaaagccg      120

ggaaaagcac caaaactgct tatatactct gcatccttcc tgtactctgg ggtgccaagc      180

cggttctccg gtagtagatc tggtactgac tttacactca ctatcagcag tctgcaacct      240

gaggactttg cgacatacta ttgccagcag cactacacaa ccccacctac atttggtcag      300

gggacaaagg tggagatcaa gcggaccgtg gccgccccga gcgtgttcat tttccctccc      360

tccgacgagc agttgaaatc gggcaccgct agcgtggtct gccttctcaa caatttctat      420

ccacgggaag ccaaagtgca gtggaaggtc gacaacgcgc tccaatccgg gaactcacag      480

gaatccgtga ctgagcagga ttccaaggac tcgacctact ccctgtcatc cacgctgacc      540

ctgagcaagg cagactacga gaagcacaag gtctacgcct gcgaagtgac acaccaggga      600

ctgtccagcc ccgtgaccaa gagcttcaac agaggagaat gcgcacctac ctcaagctct      660

ggaggaggtg gcagcgagcc ccatagtctg agctacgaca tcacagttat tcccaagttc      720

aggcccggac cgcgctggtg tgccgtgcaa ggacaagtcg acgaaaaaac ctttcttcat      780

tacgattgcg gaaataagac tgtaacgcca gtctctcctt taggtaagaa gttaaacgtc      840

actacggcgt ggaaggcaca aaaccccgtc ctgcgcgagg tcgtcgacat cctgactgaa      900

caattgtggg acatccagct cgagaattac actccaaagg agcctcttac cctgcaggct      960

agaatgtctt gcgagcaaaa ggcagagggc cactcctccg gcagctggca gttcagtttc     1020

gacggacaaa tctttctgtt attcgattca gagaagagaa tgtggactac agttcacccc     1080

ggtgcccgta aaatgaagga gaagtgggaa aacgacaaag tggtggcgac tttgttgtgg     1140

gggtggtcga tgggagactg catcggttgg ctggaagatt tcctcatggg tatggactcc     1200

actttggagc catcg                                                      1215


<210>  135
<211>  156
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.wt ectodomain

<400>  135

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
145                 150                 155     


<210>  136
<211>  468
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.wt ectodomain

<400>  136
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agctaccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtg                   468


<210>  137
<211>  156
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA ectodomain

<400>  137

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
145                 150                 155     


<210>  138
<211>  468
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.YA ectodomain

<400>  138
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtg                   468


<210>  139
<211>  156
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.AF ectodomain

<400>  139

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
145                 150                 155     


<210>  140
<211>  468
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.AF ectodomain

<400>  140
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggcttcatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtg                   468


<210>  141
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide CD8alpha hinge and transmembrane domain

<400>  141

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  142
<211>  207
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding CD8alpha hinge and 
       transmembrane domain

<400>  142
accaccacac cagctcctag acctccaact cctgctccta caatcgccag ccagcctctg       60

tctctgaggc cagaagcttg tagacctgct gcaggcggag ccgtgcatac aagaggactg      120

gatttcgcct gcgacatcta catctgggcc cctctggctg gaacatgtgg cgtgctgctg      180

ctgagcctgg tcatcaccct gtactgc                                          207


<210>  143
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide 4-1BB

<400>  143

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  144
<211>  126
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 4-1BB

<400>  144
aagcggggca gaaagaagct gctgtacatc tttaagcagc ccttcatgcg gcccgtgcag       60

accacacaag aggaagatgg ctgctcctgc agattccccg aggaagaaga aggcggctgc      120

gagctg                                                                 126


<210>  145
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide CD3zeta

<400>  145

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  146
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding CD3zeta

<400>  146
agagtgaagt tcagccgttc tgccgacgct cccgcctata agcagggaca gaaccagctg       60

tacaacgagc tgaacctggg gagaagagaa gagtacgacg tgctggacaa gcggagaggc      120

agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat      180

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc      240

agaagaggca agggacacga tggactgtac cagggcctga gcaccgccac caaggatacc      300

tatgatgccc tgcacatgca ggccctgcct ccaaga                                336


<210>  147
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide EGFP

<400>  147

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  148
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding EGFP

<400>  148
atggtgtcta aaggcgagga actgttcacc ggcgtggtgc ccattctggt ggaactggac       60

ggggatgtga acggccacaa gtttagcgtt agcggcgaag gcgaagggga tgccacatac      120

ggaaagctga ccctgaagtt catctgcacc accggcaagc tgcctgtgcc ttggcctaca      180

ctggtcacca cactgacata cggcgtgcag tgctttagca gataccccga ccatatgaag      240

cagcacgact tcttcaagtc cgccatgcct gagggctacg tgcaagagcg gaccatcttc      300

tttaaggacg acggcaacta caagaccagg gccgaagtga agtttgaggg cgacaccctg      360

gtcaaccgga tcgagctgaa gggcatcgac ttcaaagagg atggcaacat cctgggccac      420

aagctcgagt acaactacaa cagccacaac gtgtacatca tggccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccggcac aacatcgagg acggcagcgt tcagctggcc      540

gatcactacc agcagaacac ccctatcgga gatggccctg tgctgctccc cgacaatcac      600

tacctgagca cacagagcgc cctgagcaag gaccccaacg agaagaggga tcacatggtg      660

ctgctggaat ttgtgaccgc cgcaggcatc accctcggca tggacgaact gtacaaa         717


<210>  149
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide CD8hingeTM_4-1BB_CD3zeta_EGFP

<400>  149

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
65                  70                  75                  80  


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                85                  90                  95      


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            100                 105                 110         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        115                 120                 125             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    130                 135                 140                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
145                 150                 155                 160 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                165                 170                 175     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            180                 185                 190         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        195                 200                 205             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    210                 215                 220                 


Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu 
225                 230                 235                 240 


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
                245                 250                 255     


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
            260                 265                 270         


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
        275                 280                 285             


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
    290                 295                 300                 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
305                 310                 315                 320 


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
                325                 330                 335     


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
            340                 345                 350         


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
        355                 360                 365             


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
    370                 375                 380                 


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
385                 390                 395                 400 


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
                405                 410                 415     


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
            420                 425                 430         


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
        435                 440                 445             


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
    450                 455                 460                 


Thr Leu Gly Met Asp Glu Leu Tyr Lys 
465                 470             


<210>  150
<211>  1419
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding CD8hingeTM_4-1BB_CD3zeta_EGFP

<400>  150
accaccacac cagctcctag acctccaact cctgctccta caatcgccag ccagcctctg       60

tctctgaggc cagaagcttg tagacctgct gcaggcggag ccgtgcatac aagaggactg      120

gatttcgcct gcgacatcta catctgggcc cctctggctg gaacatgtgg cgtgctgctg      180

ctgagcctgg tcatcaccct gtactgcagc ctgaagcggg gcagaaagaa gctgctgtac      240

atctttaagc agcccttcat gcggcccgtg cagaccacac aagaggaaga tggctgctcc      300

tgcagattcc ccgaggaaga agaaggcggc tgcgagctga gagtgaagtt cagccgttct      360

gccgacgctc ccgcctataa gcagggacag aaccagctgt acaacgagct gaacctgggg      420

agaagagaag agtacgacgt gctggacaag cggagaggca gagatcctga gatgggcggc      480

aagcccagac ggaagaatcc tcaagagggc ctgtataatg agctgcagaa agacaagatg      540

gccgaggcct acagcgagat cggaatgaag ggcgagcgca gaagaggcaa gggacacgat      600

ggactgtacc agggcctgag caccgccacc aaggatacct atgatgccct gcacatgcag      660

gccctgcctc caagatcagg ctctggttct ggcagcggca gcatggtgtc taaaggcgag      720

gaactgttca ccggcgtggt gcccattctg gtggaactgg acggggatgt gaacggccac      780

aagtttagcg ttagcggcga aggcgaaggg gatgccacat acggaaagct gaccctgaag      840

ttcatctgca ccaccggcaa gctgcctgtg ccttggccta cactggtcac cacactgaca      900

tacggcgtgc agtgctttag cagatacccc gaccatatga agcagcacga cttcttcaag      960

tccgccatgc ctgagggcta cgtgcaagag cggaccatct tctttaagga cgacggcaac     1020

tacaagacca gggccgaagt gaagtttgag ggcgacaccc tggtcaaccg gatcgagctg     1080

aagggcatcg acttcaaaga ggatggcaac atcctgggcc acaagctcga gtacaactac     1140

aacagccaca acgtgtacat catggccgac aagcagaaga acggcatcaa ggccaacttc     1200

aagatccggc acaacatcga ggacggcagc gttcagctgg ccgatcacta ccagcagaac     1260

acccctatcg gagatggccc tgtgctgctc cccgacaatc actacctgag cacacagagc     1320

gccctgagca aggaccccaa cgagaagagg gatcacatgg tgctgctgga atttgtgacc     1380

gccgcaggca tcaccctcgg catggacgaa ctgtacaaa                            1419


<210>  151
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.wt_CD8hingeTM_4-1BB_CD3zeta_EGFP complete
       chimeric antigen receptor

<400>  151

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            260                 265                 270         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        275                 280                 285             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    290                 295                 300                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
305                 310                 315                 320 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                325                 330                 335     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            340                 345                 350         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        355                 360                 365             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
385                 390                 395                 400 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                405                 410                 415     


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            420                 425                 430         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        435                 440                 445             


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
    450                 455                 460                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
465                 470                 475                 480 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                485                 490                 495     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            500                 505                 510         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        515                 520                 525             


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
    530                 535                 540                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
545                 550                 555                 560 


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                565                 570                 575     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            580                 585                 590         


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        595                 600                 605             


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
    610                 615                 620                 


Asp Glu Leu Tyr Lys 
625                 


<210>  152
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       NKG2D.wt_CD8hingeTM_4-1BB_CD3zeta_EGFP complete chimeric antigen 
       receptor

<400>  152
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agctaccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gaggaagatg gctgctcctg cagattcccc      780

gaggaagaag aaggcggctg cgagctgaga gtgaagttca gccgttctgc cgacgctccc      840

gcctataagc agggacagaa ccagctgtac aacgagctga acctggggag aagagaagag      900

tacgacgtgc tggacaagcg gagaggcaga gatcctgaga tgggcggcaa gcccagacgg      960

aagaatcctc aagagggcct gtataatgag ctgcagaaag acaagatggc cgaggcctac     1020

agcgagatcg gaatgaaggg cgagcgcaga agaggcaagg gacacgatgg actgtaccag     1080

ggcctgagca ccgccaccaa ggatacctat gatgccctgc acatgcaggc cctgcctcca     1140

agatcaggct ctggttctgg cagcggcagc atggtgtcta aaggcgagga actgttcacc     1200

ggcgtggtgc ccattctggt ggaactggac ggggatgtga acggccacaa gtttagcgtt     1260

agcggcgaag gcgaagggga tgccacatac ggaaagctga ccctgaagtt catctgcacc     1320

accggcaagc tgcctgtgcc ttggcctaca ctggtcacca cactgacata cggcgtgcag     1380

tgctttagca gataccccga ccatatgaag cagcacgact tcttcaagtc cgccatgcct     1440

gagggctacg tgcaagagcg gaccatcttc tttaaggacg acggcaacta caagaccagg     1500

gccgaagtga agtttgaggg cgacaccctg gtcaaccgga tcgagctgaa gggcatcgac     1560

ttcaaagagg atggcaacat cctgggccac aagctcgagt acaactacaa cagccacaac     1620

gtgtacatca tggccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccggcac     1680

aacatcgagg acggcagcgt tcagctggcc gatcactacc agcagaacac ccctatcgga     1740

gatggccctg tgctgctccc cgacaatcac tacctgagca cacagagcgc cctgagcaag     1800

gaccccaacg agaagaggga tcacatggtg ctgctggaat ttgtgaccgc cgcaggcatc     1860

accctcggca tggacgaact gtacaaa                                         1887


<210>  153
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_4-1BB_CD3zeta_EGFP complete
       chimeric antigen receptor

<400>  153

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            260                 265                 270         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        275                 280                 285             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    290                 295                 300                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
305                 310                 315                 320 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                325                 330                 335     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            340                 345                 350         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        355                 360                 365             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
385                 390                 395                 400 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                405                 410                 415     


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            420                 425                 430         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        435                 440                 445             


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
    450                 455                 460                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
465                 470                 475                 480 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                485                 490                 495     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            500                 505                 510         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        515                 520                 525             


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
    530                 535                 540                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
545                 550                 555                 560 


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                565                 570                 575     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            580                 585                 590         


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        595                 600                 605             


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
    610                 615                 620                 


Asp Glu Leu Tyr Lys 
625                 


<210>  154
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       NKG2D.YA_CD8hingeTM_4-1BB_CD3zeta_EGFP complete chimeric antigen 
       receptor

<400>  154
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gaggaagatg gctgctcctg cagattcccc      780

gaggaagaag aaggcggctg cgagctgaga gtgaagttca gccgttctgc cgacgctccc      840

gcctataagc agggacagaa ccagctgtac aacgagctga acctggggag aagagaagag      900

tacgacgtgc tggacaagcg gagaggcaga gatcctgaga tgggcggcaa gcccagacgg      960

aagaatcctc aagagggcct gtataatgag ctgcagaaag acaagatggc cgaggcctac     1020

agcgagatcg gaatgaaggg cgagcgcaga agaggcaagg gacacgatgg actgtaccag     1080

ggcctgagca ccgccaccaa ggatacctat gatgccctgc acatgcaggc cctgcctcca     1140

agatcaggct ctggttctgg cagcggcagc atggtgtcta aaggcgagga actgttcacc     1200

ggcgtggtgc ccattctggt ggaactggac ggggatgtga acggccacaa gtttagcgtt     1260

agcggcgaag gcgaagggga tgccacatac ggaaagctga ccctgaagtt catctgcacc     1320

accggcaagc tgcctgtgcc ttggcctaca ctggtcacca cactgacata cggcgtgcag     1380

tgctttagca gataccccga ccatatgaag cagcacgact tcttcaagtc cgccatgcct     1440

gagggctacg tgcaagagcg gaccatcttc tttaaggacg acggcaacta caagaccagg     1500

gccgaagtga agtttgaggg cgacaccctg gtcaaccgga tcgagctgaa gggcatcgac     1560

ttcaaagagg atggcaacat cctgggccac aagctcgagt acaactacaa cagccacaac     1620

gtgtacatca tggccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccggcac     1680

aacatcgagg acggcagcgt tcagctggcc gatcactacc agcagaacac ccctatcgga     1740

gatggccctg tgctgctccc cgacaatcac tacctgagca cacagagcgc cctgagcaag     1800

gaccccaacg agaagaggga tcacatggtg ctgctggaat ttgtgaccgc cgcaggcatc     1860

accctcggca tggacgaact gtacaaa                                         1887


<210>  155
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.AF_CD8hingeTM_4-1BB_CD3zeta_EGFP complete
       chimeric antigen receptor

<400>  155

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Phe Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            260                 265                 270         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        275                 280                 285             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    290                 295                 300                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
305                 310                 315                 320 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                325                 330                 335     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            340                 345                 350         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        355                 360                 365             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
385                 390                 395                 400 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                405                 410                 415     


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            420                 425                 430         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        435                 440                 445             


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
    450                 455                 460                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
465                 470                 475                 480 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                485                 490                 495     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            500                 505                 510         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        515                 520                 525             


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
    530                 535                 540                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
545                 550                 555                 560 


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                565                 570                 575     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            580                 585                 590         


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        595                 600                 605             


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
    610                 615                 620                 


Asp Glu Leu Tyr Lys 
625                 


<210>  156
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       NKG2D.AF_CD8hingeTM_4-1BB_CD3zeta_EGFP complete chimeric antigen 
       receptor

<400>  156
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggcttcatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gaggaagatg gctgctcctg cagattcccc      780

gaggaagaag aaggcggctg cgagctgaga gtgaagttca gccgttctgc cgacgctccc      840

gcctataagc agggacagaa ccagctgtac aacgagctga acctggggag aagagaagag      900

tacgacgtgc tggacaagcg gagaggcaga gatcctgaga tgggcggcaa gcccagacgg      960

aagaatcctc aagagggcct gtataatgag ctgcagaaag acaagatggc cgaggcctac     1020

agcgagatcg gaatgaaggg cgagcgcaga agaggcaagg gacacgatgg actgtaccag     1080

ggcctgagca ccgccaccaa ggatacctat gatgccctgc acatgcaggc cctgcctcca     1140

agatcaggct ctggttctgg cagcggcagc atggtgtcta aaggcgagga actgttcacc     1200

ggcgtggtgc ccattctggt ggaactggac ggggatgtga acggccacaa gtttagcgtt     1260

agcggcgaag gcgaagggga tgccacatac ggaaagctga ccctgaagtt catctgcacc     1320

accggcaagc tgcctgtgcc ttggcctaca ctggtcacca cactgacata cggcgtgcag     1380

tgctttagca gataccccga ccatatgaag cagcacgact tcttcaagtc cgccatgcct     1440

gagggctacg tgcaagagcg gaccatcttc tttaaggacg acggcaacta caagaccagg     1500

gccgaagtga agtttgaggg cgacaccctg gtcaaccgga tcgagctgaa gggcatcgac     1560

ttcaaagagg atggcaacat cctgggccac aagctcgagt acaactacaa cagccacaac     1620

gtgtacatca tggccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccggcac     1680

aacatcgagg acggcagcgt tcagctggcc gatcactacc agcagaacac ccctatcgga     1740

gatggccctg tgctgctccc cgacaatcac tacctgagca cacagagcgc cctgagcaag     1800

gaccccaacg agaagaggga tcacatggtg ctgctggaat ttgtgaccgc cgcaggcatc     1860

accctcggca tggacgaact gtacaaa                                         1887


<210>  157
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_EGFP silent chimeric 
       antigen receptor

<400>  157

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu 
225                 230                 235                 240 


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
                245                 250                 255     


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
            260                 265                 270         


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
        275                 280                 285             


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
    290                 295                 300                 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
305                 310                 315                 320 


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
                325                 330                 335     


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
            340                 345                 350         


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
        355                 360                 365             


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
    370                 375                 380                 


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
385                 390                 395                 400 


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
                405                 410                 415     


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
            420                 425                 430         


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
        435                 440                 445             


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
    450                 455                 460                 


Thr Leu Gly Met Asp Glu Leu Tyr Lys 
465                 470             


<210>  158
<211>  1419
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.YA_CD8hingeTM_EGFP 
       silent chimeric antigen receptor

<400>  158
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgctcagg ctctggttct ggcagcggca gcatggtgtc taaaggcgag      720

gaactgttca ccggcgtggt gcccattctg gtggaactgg acggggatgt gaacggccac      780

aagtttagcg ttagcggcga aggcgaaggg gatgccacat acggaaagct gaccctgaag      840

ttcatctgca ccaccggcaa gctgcctgtg ccttggccta cactggtcac cacactgaca      900

tacggcgtgc agtgctttag cagatacccc gaccatatga agcagcacga cttcttcaag      960

tccgccatgc ctgagggcta cgtgcaagag cggaccatct tctttaagga cgacggcaac     1020

tacaagacca gggccgaagt gaagtttgag ggcgacaccc tggtcaaccg gatcgagctg     1080

aagggcatcg acttcaaaga ggatggcaac atcctgggcc acaagctcga gtacaactac     1140

aacagccaca acgtgtacat catggccgac aagcagaaga acggcatcaa ggccaacttc     1200

aagatccggc acaacatcga ggacggcagc gttcagctgg ccgatcacta ccagcagaac     1260

acccctatcg gagatggccc tgtgctgctc cccgacaatc actacctgag cacacagagc     1320

gccctgagca aggaccccaa cgagaagagg gatcacatgg tgctgctgga atttgtgacc     1380

gccgcaggca tcaccctcgg catggacgaa ctgtacaaa                            1419


<210>  159
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM silent chimeric antigen 
       receptor

<400>  159

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys 
225 


<210>  160
<211>  675
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.YA_CD8hingeTM silent 
       chimeric antigen receptor

<400>  160
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgc                                                       675


<210>  161
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_4-1BBtraf2_CD3zeta_EGFP 
       complete chimeric antigen receptor

<400>  161

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Ala Ala Ala Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Ala Ala Ala Gly Gly Cys Glu Leu Arg Val Lys 
            260                 265                 270         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        275                 280                 285             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    290                 295                 300                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
305                 310                 315                 320 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                325                 330                 335     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            340                 345                 350         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        355                 360                 365             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
385                 390                 395                 400 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                405                 410                 415     


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            420                 425                 430         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        435                 440                 445             


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
    450                 455                 460                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
465                 470                 475                 480 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                485                 490                 495     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            500                 505                 510         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        515                 520                 525             


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
    530                 535                 540                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
545                 550                 555                 560 


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                565                 570                 575     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            580                 585                 590         


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        595                 600                 605             


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
    610                 615                 620                 


Asp Glu Leu Tyr Lys 
625                 


<210>  162
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       NKG2D.YA_CD8hingeTM_4-1BBtraf2_CD3zeta_EGFP complete chimeric 
       antigen receptor

<400>  162
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gccgctgcag gctgctcctg cagattcccc      780

gaggctgccg caggcggctg cgagctgaga gtgaagttca gccgttctgc cgacgctccc      840

gcctataagc agggacagaa ccagctgtac aacgagctga acctggggag aagagaagag      900

tacgacgtgc tggacaagcg gagaggcaga gatcctgaga tgggcggcaa gcccagacgg      960

aagaatcctc aagagggcct gtataatgag ctgcagaaag acaagatggc cgaggcctac     1020

agcgagatcg gaatgaaggg cgagcgcaga agaggcaagg gacacgatgg actgtaccag     1080

ggcctgagca ccgccaccaa ggatacctat gatgccctgc acatgcaggc cctgcctcca     1140

agatcaggct ctggttctgg cagcggcagc atggtgtcta aaggcgagga actgttcacc     1200

ggcgtggtgc ccattctggt ggaactggac ggggatgtga acggccacaa gtttagcgtt     1260

agcggcgaag gcgaagggga tgccacatac ggaaagctga ccctgaagtt catctgcacc     1320

accggcaagc tgcctgtgcc ttggcctaca ctggtcacca cactgacata cggcgtgcag     1380

tgctttagca gataccccga ccatatgaag cagcacgact tcttcaagtc cgccatgcct     1440

gagggctacg tgcaagagcg gaccatcttc tttaaggacg acggcaacta caagaccagg     1500

gccgaagtga agtttgaggg cgacaccctg gtcaaccgga tcgagctgaa gggcatcgac     1560

ttcaaagagg atggcaacat cctgggccac aagctcgagt acaactacaa cagccacaac     1620

gtgtacatca tggccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccggcac     1680

aacatcgagg acggcagcgt tcagctggcc gatcactacc agcagaacac ccctatcgga     1740

gatggccctg tgctgctccc cgacaatcac tacctgagca cacagagcgc cctgagcaag     1800

gaccccaacg agaagaggga tcacatggtg ctgctggaat ttgtgaccgc cgcaggcatc     1860

accctcggca tggacgaact gtacaaa                                         1887


<210>  163
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_4-1BB_CD3itam_EGFP complete
       chimeric antigen receptor

<400>  163

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            260                 265                 270         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        275                 280                 285             


Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp Val Leu 
    290                 295                 300                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
305                 310                 315                 320 


Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met 
                325                 330                 335     


Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            340                 345                 350         


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        355                 360                 365             


Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
385                 390                 395                 400 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                405                 410                 415     


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            420                 425                 430         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        435                 440                 445             


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
    450                 455                 460                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
465                 470                 475                 480 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                485                 490                 495     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            500                 505                 510         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        515                 520                 525             


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
    530                 535                 540                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
545                 550                 555                 560 


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                565                 570                 575     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            580                 585                 590         


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        595                 600                 605             


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
    610                 615                 620                 


Asp Glu Leu Tyr Lys 
625                 


<210>  164
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       NKG2D.YA_CD8hingeTM_4-1BB_CD3itam_EGFP complete chimeric antigen 
       receptor

<400>  164
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gaggaagatg gctgctcctg cagattcccc      780

gaggaagaag aaggcggctg cgagctgaga gtgaagttca gccgttctgc cgacgctccc      840

gcctataagc agggacagaa ccagctgttc aacgagctga acctggggag aagagaagag      900

ttcgacgtgc tggacaagcg gagaggcaga gatcctgaga tgggcggcaa gcccagacgg      960

aagaatcctc aagagggcct gtttaatgag ctgcagaaag acaagatggc cgaggccttc     1020

agcgagatcg gaatgaaggg cgagcgcaga agaggcaagg gacacgatgg actgttccag     1080

ggcctgagca ccgccaccaa ggataccttt gatgccctgc acatgcaggc cctgcctcca     1140

agatcaggct ctggttctgg cagcggcagc atggtgtcta aaggcgagga actgttcacc     1200

ggcgtggtgc ccattctggt ggaactggac ggggatgtga acggccacaa gtttagcgtt     1260

agcggcgaag gcgaagggga tgccacatac ggaaagctga ccctgaagtt catctgcacc     1320

accggcaagc tgcctgtgcc ttggcctaca ctggtcacca cactgacata cggcgtgcag     1380

tgctttagca gataccccga ccatatgaag cagcacgact tcttcaagtc cgccatgcct     1440

gagggctacg tgcaagagcg gaccatcttc tttaaggacg acggcaacta caagaccagg     1500

gccgaagtga agtttgaggg cgacaccctg gtcaaccgga tcgagctgaa gggcatcgac     1560

ttcaaagagg atggcaacat cctgggccac aagctcgagt acaactacaa cagccacaac     1620

gtgtacatca tggccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccggcac     1680

aacatcgagg acggcagcgt tcagctggcc gatcactacc agcagaacac ccctatcgga     1740

gatggccctg tgctgctccc cgacaatcac tacctgagca cacagagcgc cctgagcaag     1800

gaccccaacg agaagaggga tcacatggtg ctgctggaat ttgtgaccgc cgcaggcatc     1860

accctcggca tggacgaact gtacaaa                                         1887


<210>  165
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_4-1BBtraf2_CD3itam_EGFP 
       complete chimeric antigen receptor

<400>  165

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Ala Ala Ala Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Ala Ala Ala Gly Gly Cys Glu Leu Arg Val Lys 
            260                 265                 270         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        275                 280                 285             


Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp Val Leu 
    290                 295                 300                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
305                 310                 315                 320 


Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met 
                325                 330                 335     


Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            340                 345                 350         


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        355                 360                 365             


Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
385                 390                 395                 400 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                405                 410                 415     


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            420                 425                 430         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        435                 440                 445             


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
    450                 455                 460                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
465                 470                 475                 480 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                485                 490                 495     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            500                 505                 510         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        515                 520                 525             


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
    530                 535                 540                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
545                 550                 555                 560 


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                565                 570                 575     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            580                 585                 590         


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        595                 600                 605             


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
    610                 615                 620                 


Asp Glu Leu Tyr Lys 
625                 


<210>  166
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       NKG2D.YA_CD8hingeTM_4-1BBtraf2_CD3itam_EGFP complete chimeric 
       antigen receptor

<400>  166
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gccgctgcag gctgctcctg cagattcccc      780

gaggctgccg caggcggctg cgagctgaga gtgaagttca gccgttctgc cgacgctccc      840

gcctataagc agggacagaa ccagctgttc aacgagctga acctggggag aagagaagag      900

ttcgacgtgc tggacaagcg gagaggcaga gatcctgaga tgggcggcaa gcccagacgg      960

aagaatcctc aagagggcct gtttaatgag ctgcagaaag acaagatggc cgaggccttc     1020

agcgagatcg gaatgaaggg cgagcgcaga agaggcaagg gacacgatgg actgttccag     1080

ggcctgagca ccgccaccaa ggataccttt gatgccctgc acatgcaggc cctgcctcca     1140

agatcaggct ctggttctgg cagcggcagc atggtgtcta aaggcgagga actgttcacc     1200

ggcgtggtgc ccattctggt ggaactggac ggggatgtga acggccacaa gtttagcgtt     1260

agcggcgaag gcgaagggga tgccacatac ggaaagctga ccctgaagtt catctgcacc     1320

accggcaagc tgcctgtgcc ttggcctaca ctggtcacca cactgacata cggcgtgcag     1380

tgctttagca gataccccga ccatatgaag cagcacgact tcttcaagtc cgccatgcct     1440

gagggctacg tgcaagagcg gaccatcttc tttaaggacg acggcaacta caagaccagg     1500

gccgaagtga agtttgaggg cgacaccctg gtcaaccgga tcgagctgaa gggcatcgac     1560

ttcaaagagg atggcaacat cctgggccac aagctcgagt acaactacaa cagccacaac     1620

gtgtacatca tggccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccggcac     1680

aacatcgagg acggcagcgt tcagctggcc gatcactacc agcagaacac ccctatcgga     1740

gatggccctg tgctgctccc cgacaatcac tacctgagca cacagagcgc cctgagcaag     1800

gaccccaacg agaagaggga tcacatggtg ctgctggaat ttgtgaccgc cgcaggcatc     1860

accctcggca tggacgaact gtacaaa                                         1887


<210>  167
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_4-1BB_EGFP complete 
       chimeric antigen receptor

<400>  167

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ser Gly Ser 
            260                 265                 270         


Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
        275                 280                 285             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
    290                 295                 300                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
305                 310                 315                 320 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                325                 330                 335     


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
            340                 345                 350         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        355                 360                 365             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
    370                 375                 380                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
385                 390                 395                 400 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                405                 410                 415     


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
            420                 425                 430         


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
        435                 440                 445             


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    450                 455                 460                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
465                 470                 475                 480 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                485                 490                 495     


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
            500                 505                 510         


Asp Glu Leu Tyr Lys 
        515         


<210>  168
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.YA_CD8hingeTM_4-1BB_EGFP
       complete chimeric antigen receptor

<400>  168
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gaggaagatg gctgctcctg cagattcccc      780

gaggaagaag aaggcggctg cgagctgtca ggctctggtt ctggcagcgg cagcatggtg      840

tctaaaggcg aggaactgtt caccggcgtg gtgcccattc tggtggaact ggacggggat      900

gtgaacggcc acaagtttag cgttagcggc gaaggcgaag gggatgccac atacggaaag      960

ctgaccctga agttcatctg caccaccggc aagctgcctg tgccttggcc tacactggtc     1020

accacactga catacggcgt gcagtgcttt agcagatacc ccgaccatat gaagcagcac     1080

gacttcttca agtccgccat gcctgagggc tacgtgcaag agcggaccat cttctttaag     1140

gacgacggca actacaagac cagggccgaa gtgaagtttg agggcgacac cctggtcaac     1200

cggatcgagc tgaagggcat cgacttcaaa gaggatggca acatcctggg ccacaagctc     1260

gagtacaact acaacagcca caacgtgtac atcatggccg acaagcagaa gaacggcatc     1320

aaggccaact tcaagatccg gcacaacatc gaggacggca gcgttcagct ggccgatcac     1380

taccagcaga acacccctat cggagatggc cctgtgctgc tccccgacaa tcactacctg     1440

agcacacaga gcgccctgag caaggacccc aacgagaaga gggatcacat ggtgctgctg     1500

gaatttgtga ccgccgcagg catcaccctc ggcatggacg aactgtacaa a              1551


<210>  169
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide NKG2D.YA_CD8hingeTM_4-1BB complete chimeric 
       antigen receptor

<400>  169

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Ala His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
225                 230                 235                 240 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                245                 250                 255     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            260                 265                 


<210>  170
<211>  807
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding NKG2D.YA_CD8hingeTM_4-1BB 
       complete chimeric antigen receptor

<400>  170
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctctgttca atcaagaggt gcagatccct ctgaccgaga gctactgtgg cccctgtcct      120

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      180

tacgagagcc aggccagctg catgagccag aatgccagcc tgctgaaggt gtacagcaaa      240

gaggaccagg atctgctgaa gctggtcaag agcgcccact ggatgggact cgtgcacatc      300

cctacaaacg gcagctggca gtgggaggac ggctctatcc tgtctcctaa cctgctgacc      360

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagctttaa gggctacatc      420

gagaactgca gcacccctaa cacctacatc tgtatgcagc ggaccgtgac caccacacca      480

gctcctagac ctccaactcc tgctcctaca atcgccagcc agcctctgtc tctgaggcca      540

gaagcttgta gacctgctgc aggcggagcc gtgcatacaa gaggactgga tttcgcctgc      600

gacatctaca tctgggcccc tctggctgga acatgtggcg tgctgctgct gagcctggtc      660

atcaccctgt actgcagcct gaagcggggc agaaagaagc tgctgtacat ctttaagcag      720

cccttcatgc ggcccgtgca gaccacacaa gaggaagatg gctgctcctg cagattcccc      780

gaggaagaag aaggcggctg cgagctg                                          807


<210>  171
<211>  736
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide CD19scFv_CD8hingeTM_4-1BB_CD3zeta_EGFP complete
       chimeric antigen receptor

<400>  171

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            500                 505                 510         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
        515                 520                 525             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
    530                 535                 540                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
545                 550                 555                 560 


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
                565                 570                 575     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            580                 585                 590         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        595                 600                 605             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    610                 615                 620                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
625                 630                 635                 640 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
                645                 650                 655     


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
            660                 665                 670         


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        675                 680                 685             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
    690                 695                 700                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
705                 710                 715                 720 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                725                 730                 735     


<210>  172
<211>  2208
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       CD19scFv_CD8hingeTM_4-1BB_CD3zeta_EGFP complete chimeric antigen 
       receptor

<400>  172
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctgacatcc agatgaccca gacaaccagc agcctgtctg ccagcctggg cgatagagtg      120

accatcagct gtagagccag ccaggacatc agcaagtacc tgaactggta tcagcagaaa      180

cccgacggca ccgtgaagct gctgatctac cacaccagca gactgcacag cggcgtgcca      240

agcagatttt ctggcagcgg ctctggcacc gactacagcc tgacaatcag caacctggaa      300

caagaggata tcgctaccta cttctgccag caaggcaaca ccctgcctta cacctttggc      360

ggaggcacca agctggaaat cacaggcggc ggaggaagcg gaggcggagg atctggtggt      420

ggtggatctg aagtgaaact gcaagagtct ggccctggcc tggtggcccc atctcaatct      480

ctgagcgtga cctgtaccgt cagcggagtg tccctgcctg attatggcgt gtcctggatc      540

cggcagcctc ctagaaaagg cctggaatgg ctgggcgtga tctggggcag cgagacaacc      600

tactacaaca gcgccctgaa gtcccggctg accatcatca aggacaactc caagagccag      660

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatctacta ttgcgccaag      720

cactactact acggcggcag ctacgccatg gattattggg gccagggcac cagcgtgacc      780

gtttcttcta ccaccacacc agctcctaga cctccaactc ctgctcctac aatcgccagc      840

cagcctctgt ctctgaggcc agaagcttgt agacctgctg caggcggagc cgtgcataca      900

agaggactgg atttcgcctg cgacatctac atctgggccc ctctggctgg aacatgtggc      960

gtgctgctgc tgagcctggt catcaccctg tactgcagcc tgaagcgggg cagaaagaag     1020

ctgctgtaca tctttaagca gcccttcatg cggcccgtgc agaccacaca agaggaagat     1080

ggctgctcct gcagattccc cgaggaagaa gaaggcggct gcgagctgag agtgaagttc     1140

agccgttctg ccgacgctcc cgcctataag cagggacaga accagctgta caacgagctg     1200

aacctgggga gaagagaaga gtacgacgtg ctggacaagc ggagaggcag agatcctgag     1260

atgggcggca agcccagacg gaagaatcct caagagggcc tgtataatga gctgcagaaa     1320

gacaagatgg ccgaggccta cagcgagatc ggaatgaagg gcgagcgcag aagaggcaag     1380

ggacacgatg gactgtacca gggcctgagc accgccacca aggataccta tgatgccctg     1440

cacatgcagg ccctgcctcc aagatcaggc tctggttctg gcagcggcag catggtgtct     1500

aaaggcgagg aactgttcac cggcgtggtg cccattctgg tggaactgga cggggatgtg     1560

aacggccaca agtttagcgt tagcggcgaa ggcgaagggg atgccacata cggaaagctg     1620

accctgaagt tcatctgcac caccggcaag ctgcctgtgc cttggcctac actggtcacc     1680

acactgacat acggcgtgca gtgctttagc agataccccg accatatgaa gcagcacgac     1740

ttcttcaagt ccgccatgcc tgagggctac gtgcaagagc ggaccatctt ctttaaggac     1800

gacggcaact acaagaccag ggccgaagtg aagtttgagg gcgacaccct ggtcaaccgg     1860

atcgagctga agggcatcga cttcaaagag gatggcaaca tcctgggcca caagctcgag     1920

tacaactaca acagccacaa cgtgtacatc atggccgaca agcagaagaa cggcatcaag     1980

gccaacttca agatccggca caacatcgag gacggcagcg ttcagctggc cgatcactac     2040

cagcagaaca cccctatcgg agatggccct gtgctgctcc ccgacaatca ctacctgagc     2100

acacagagcg ccctgagcaa ggaccccaac gagaagaggg atcacatggt gctgctggaa     2160

tttgtgaccg ccgcaggcat caccctcggc atggacgaac tgtacaaa                  2208


<210>  173
<211>  1115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide 
       CD19scFv_CD8hingeTM_4-1BB_CD3zeta_EGFP-T2A-NKG2D.YA_CD8hingeTM

<400>  173

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            500                 505                 510         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
        515                 520                 525             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
    530                 535                 540                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
545                 550                 555                 560 


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
                565                 570                 575     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            580                 585                 590         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        595                 600                 605             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    610                 615                 620                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
625                 630                 635                 640 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
                645                 650                 655     


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
            660                 665                 670         


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        675                 680                 685             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
    690                 695                 700                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
705                 710                 715                 720 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                725                 730                 735     


Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            740                 745                 750         


Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu 
        755                 760                 765             


Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Leu Phe 
    770                 775                 780                 


Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
785                 790                 795                 800 


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
                805                 810                 815     


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
            820                 825                 830         


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
        835                 840                 845             


Leu Val Lys Ser Ala His Trp Met Gly Leu Val His Ile Pro Thr Asn 
    850                 855                 860                 


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
865                 870                 875                 880 


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
                885                 890                 895     


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
            900                 905                 910         


Met Gln Arg Thr Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
        915                 920                 925             


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
    930                 935                 940                 


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
945                 950                 955                 960 


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
                965                 970                 975     


Lys Leu Val Lys Ser Ala His Trp Met Gly Leu Val His Ile Pro Thr 
            980                 985                 990         


Asn Gly Ser Trp Gln Trp Glu Asp  Gly Ser Ile Leu Ser  Pro Asn Leu 
        995                 1000                 1005             


Leu Thr  Ile Ile Glu Met Gln  Lys Gly Asp Cys Ala  Leu Tyr Ala 
    1010                 1015                 1020             


Ser Ser  Phe Lys Gly Tyr Ile  Glu Asn Cys Ser Thr  Pro Asn Thr 
    1025                 1030                 1035             


Tyr Ile  Cys Met Gln Arg Thr  Val Thr Thr Thr Pro  Ala Pro Arg 
    1040                 1045                 1050             


Pro Pro  Thr Pro Ala Pro Thr  Ile Ala Ser Gln Pro  Leu Ser Leu 
    1055                 1060                 1065             


Arg Pro  Glu Ala Cys Arg Pro  Ala Ala Gly Gly Ala  Val His Thr 
    1070                 1075                 1080             


Arg Gly  Leu Asp Phe Ala Cys  Asp Ile Tyr Ile Trp  Ala Pro Leu 
    1085                 1090                 1095             


Ala Gly  Thr Cys Gly Val Leu  Leu Leu Ser Leu Val  Ile Thr Leu 
    1100                 1105                 1110             


Tyr Cys  
    1115 


<210>  174
<211>  3345
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding 
       CD19scFv_CD8hingeTM_4-1BB_CD3zeta_EGFP-T2A-NKG2D.YA_CD8hingeTM

<400>  174
atggcattgc ctgttacagc tctgctgctg cccctggctc tgcttctgca tgctgccaga       60

cctgacatcc agatgaccca gacaaccagc agcctgtctg ccagcctggg cgatagagtg      120

accatcagct gtagagccag ccaggacatc agcaagtacc tgaactggta tcagcagaaa      180

cccgacggca ccgtgaagct gctgatctac cacaccagca gactgcacag cggcgtgcca      240

agcagatttt ctggcagcgg ctctggcacc gactacagcc tgacaatcag caacctggaa      300

caagaggata tcgctaccta cttctgccag caaggcaaca ccctgcctta cacctttggc      360

ggaggcacca agctggaaat cacaggcggc ggaggaagcg gaggcggagg atctggtggt      420

ggtggatctg aagtgaaact gcaagagtct ggccctggcc tggtggcccc atctcaatct      480

ctgagcgtga cctgtaccgt cagcggagtg tccctgcctg attatggcgt gtcctggatc      540

cggcagcctc ctagaaaagg cctggaatgg ctgggcgtga tctggggcag cgagacaacc      600

tactacaaca gcgccctgaa gtcccggctg accatcatca aggacaactc caagagccag      660

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatctacta ttgcgccaag      720

cactactact acggcggcag ctacgccatg gattattggg gccagggcac cagcgtgacc      780

gtttcttcta ccaccacacc agctcctaga cctccaactc ctgctcctac aatcgccagc      840

cagcctctgt ctctgaggcc agaagcttgt agacctgctg caggcggagc cgtgcataca      900

agaggactgg atttcgcctg cgacatctac atctgggccc ctctggctgg aacatgtggc      960

gtgctgctgc tgagcctggt catcaccctg tactgcagcc tgaagcgggg cagaaagaag     1020

ctgctgtaca tctttaagca gcccttcatg cggcccgtgc agaccacaca agaggaagat     1080

ggctgctcct gcagattccc cgaggaagaa gaaggcggct gcgagctgag agtgaagttc     1140

agccgttctg ccgacgctcc cgcctataag cagggacaga accagctgta caacgagctg     1200

aacctgggga gaagagaaga gtacgacgtg ctggacaagc ggagaggcag agatcctgag     1260

atgggcggca agcccagacg gaagaatcct caagagggcc tgtataatga gctgcagaaa     1320

gacaagatgg ccgaggccta cagcgagatc ggaatgaagg gcgagcgcag aagaggcaag     1380

ggacacgatg gactgtacca gggcctgagc accgccacca aggataccta tgatgccctg     1440

cacatgcagg ccctgcctcc aagatcaggc tctggttctg gcagcggcag catggtgtct     1500

aaaggcgagg aactgttcac cggcgtggtg cccattctgg tggaactgga cggggatgtg     1560

aacggccaca agtttagcgt tagcggcgaa ggcgaagggg atgccacata cggaaagctg     1620

accctgaagt tcatctgcac caccggcaag ctgcctgtgc cttggcctac actggtcacc     1680

acactgacat acggcgtgca gtgctttagc agataccccg accatatgaa gcagcacgac     1740

ttcttcaagt ccgccatgcc tgagggctac gtgcaagagc ggaccatctt ctttaaggac     1800

gacggcaact acaagaccag ggccgaagtg aagtttgagg gcgacaccct ggtcaaccgg     1860

atcgagctga agggcatcga cttcaaagag gatggcaaca tcctgggcca caagctcgag     1920

tacaactaca acagccacaa cgtgtacatc atggccgaca agcagaagaa cggcatcaag     1980

gccaacttca agatccggca caacatcgag gacggcagcg ttcagctggc cgatcactac     2040

cagcagaaca cccctatcgg agatggccct gtgctgctcc ccgacaatca ctacctgagc     2100

acacagagcg ccctgagcaa ggaccccaac gagaagaggg atcacatggt gctgctggaa     2160

tttgtgaccg ccgcaggcat caccctcggc atggacgaac tgtacaaact cgagggcggc     2220

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctagg     2280

atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg     2340

atcccactgt tcaaccagga ggttcagatt ccgctgaccg aaagctactg tggaccatgt     2400

cccaagaact ggatctgcta caaaaacaat tgttatcaat ttttcgacga aagcaagaat     2460

tggtacgaaa gccaggcttc atgcatgagc caaaatgcat ccctgctgaa ggtgtacagc     2520

aaggaggacc aggacctgct gaaacttgtc aaatccgctc actggatggg actggtccat     2580

attcctacaa atggatcctg gcagtgggag gatggctcta tcctgtctcc caatctcctg     2640

actatcatag agatgcagaa gggagattgt gcattgtatg ctagttcatt caagggatac     2700

attgaaaact gctcaacacc taatacctac atatgtatgc agcgcacagt gcagatccct     2760

ctgaccgaga gctactgtgg cccctgtcct aagaactgga tctgctacaa gaacaactgc     2820

taccagttct tcgacgagag caagaattgg tacgagagcc aggccagctg catgagccag     2880

aatgccagcc tgctgaaggt gtacagcaaa gaggaccagg atctgctgaa gctggtcaag     2940

agcgcccact ggatgggact cgtgcacatc cctacaaacg gcagctggca gtgggaggac     3000

ggctctatcc tgtctcctaa cctgctgacc atcatcgaga tgcagaaggg cgactgcgcc     3060

ctgtacgcca gcagctttaa gggctacatc gagaactgca gcacccctaa cacctacatc     3120

tgtatgcagc ggaccgtgac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc     3180

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca     3240

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg     3300

acttgtgggg tccttctcct gtcactggtt atcacccttt actgc                     3345


<210>  175
<211>  161
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide FLAG_6xHis_mutIL2

<400>  175

Gly Ser Ser Gly Ser Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His 
1               5                   10                  15      


His His His His His His Gly Ser Ser Gly Ser Ser Ala Pro Thr Ser 
            20                  25                  30          


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
        35                  40                  45              


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
    50                  55                  60                  


Thr Ala Met Leu Thr Lys Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
65                  70                  75                  80  


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
                85                  90                  95      


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
            100                 105                 110         


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
        115                 120                 125             


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
    130                 135                 140                 


Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu 
145                 150                 155                 160 


Thr 
    


<210>  176
<211>  483
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding FLAG_6xHis_mutIL2

<400>  176
ggaagtagcg gtagtagtga ttacaaggac gatgacgaca agcaccacca tcatcatcat       60

caccacggta gcagcggcag cagtgccccc acctctagca gcacaaagaa gacccagctg      120

caactggaac acctcctgct ggacctgcag atgatcctga acggcatcaa caactacaag      180

aaccccaagc tgaccgccat gctgaccaaa aagttttaca tgcccaagaa ggccaccgag      240

cttaaacacc tgcaatgcct tgaggaggag ctgaagcccc tggaggaggt actgaacctg      300

gcccagagca agaactttca tctgaggccc agggacctga ttagcaacat caacgtgatc      360

gtgttggagt tgaagggcag cgagaccacg ttcatgtgcg agtacgccga cgagacggcc      420

accatagtgg agtttcttaa caggtggatc accttctcac agtctatcat cagcaccctg      480

acc                                                                    483


<210>  177
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP2.R80W_FLAG_6xHis_mutIL2

<400>  177

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser Gly Thr Gly Ser Ser Gly Ser Ser Asp Tyr Lys Asp 
            180                 185                 190         


Asp Asp Asp Lys His His His His His His His His Gly Ser Ser Gly 
        195                 200                 205             


Ser Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
    210                 215                 220                 


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
225                 230                 235                 240 


Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Lys Lys Phe Tyr Met 
                245                 250                 255     


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
            260                 265                 270         


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
        275                 280                 285             


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
    290                 295                 300                 


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
305                 310                 315                 320 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
                325                 330                 335     


Ser Ile Ile Ser Thr Leu Thr 
            340             


<210>  178
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2.R80W_FLAG_6xHis_mutIL2

<400>  178
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgatgtcat tccactattt ctcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540

ggtaccggta gtagcggtag tagtgattac aaggacgatg acgacaagca ccaccatcat      600

catcatcacc acggtagcag cggcagcagt gcccccacct ctagcagcac aaagaagacc      660

cagctgcaac tggaacacct cctgctggac ctgcagatga tcctgaacgg catcaacaac      720

tacaagaacc ccaagctgac cgccatgctg accaaaaagt tttacatgcc caagaaggcc      780

accgagctta aacacctgca atgccttgag gaggagctga agcccctgga ggaggtactg      840

aacctggccc agagcaagaa ctttcatctg aggcccaggg acctgattag caacatcaac      900

gtgatcgtgt tggagttgaa gggcagcgag accacgttca tgtgcgagta cgccgacgag      960

acggccacca tagtggagtt tcttaacagg tggatcacct tctcacagtc tatcatcagc     1020

accctgacc                                                             1029


<210>  179
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP2.S2_FLAG_6xHis_mutIL2

<400>  179

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Leu Met Arg Ile Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser Gly Thr Gly Ser Ser Gly Ser Ser Asp Tyr Lys Asp 
            180                 185                 190         


Asp Asp Asp Lys His His His His His His His His Gly Ser Ser Gly 
        195                 200                 205             


Ser Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
    210                 215                 220                 


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
225                 230                 235                 240 


Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Lys Lys Phe Tyr Met 
                245                 250                 255     


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
            260                 265                 270         


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
        275                 280                 285             


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
    290                 295                 300                 


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
305                 310                 315                 320 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
                325                 330                 335     


Ser Ile Ile Ser Thr Leu Thr 
            340             


<210>  180
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2.S2_FLAG_6xHis_mutIL2

<400>  180
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactctga tgaggatttg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540

ggtaccggta gtagcggtag tagtgattac aaggacgatg acgacaagca ccaccatcat      600

catcatcacc acggtagcag cggcagcagt gcccccacct ctagcagcac aaagaagacc      660

cagctgcaac tggaacacct cctgctggac ctgcagatga tcctgaacgg catcaacaac      720

tacaagaacc ccaagctgac cgccatgctg accaaaaagt tttacatgcc caagaaggcc      780

accgagctta aacacctgca atgccttgag gaggagctga agcccctgga ggaggtactg      840

aacctggccc agagcaagaa ctttcatctg aggcccaggg acctgattag caacatcaac      900

gtgatcgtgt tggagttgaa gggcagcgag accacgttca tgtgcgagta cgccgacgag      960

acggccacca tagtggagtt tcttaacagg tggatcacct tctcacagtc tatcatcagc     1020

accctgacc                                                             1029


<210>  181
<211>  412
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP2.R80W_Fc1

<400>  181

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        195                 200                 205             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    210                 215                 220                 


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
225                 230                 235                 240 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                245                 250                 255     


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            260                 265                 270         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        275                 280                 285             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    290                 295                 300                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
305                 310                 315                 320 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                325                 330                 335     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            340                 345                 350         


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        355                 360                 365             


Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    370                 375                 380                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
385                 390                 395                 400 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410         


<210>  182
<211>  1236
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2.R80W_Fc1

<400>  182
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgatgtcat tccactattt ctcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540

gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg      600

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      660

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      720

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      780

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      840

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      900

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      960

gacgagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct     1020

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactatga cactaccccg     1080

cccgtgctgg attccgacgg aagcttcttc ctgtactccg acctgaccgt ggacaagtcg     1140

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac     1200

tacacccaga agtcactgag cctctccccc ggaaag                               1236


<210>  183
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_mutIL2

<400>  183

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
225                 230                 235                 240 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
                245                 250                 255     


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
            260                 265                 270         


Ala Met Leu Thr Lys Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
        275                 280                 285             


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
    290                 295                 300                 


Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
305                 310                 315                 320 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
                325                 330                 335     


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
            340                 345                 350         


Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
        355                 360                 365             


<210>  184
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_mutIL2

<400>  184
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

aaggagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctga agtccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagcgcccc cacctctagc      720

agcacaaaga agacccagct gcaactggaa cacctcctgc tggacctgca gatgatcctg      780

aacggcatca acaactacaa gaaccccaag ctgaccgcca tgctgaccaa aaagttttac      840

atgcccaaga aggccaccga gcttaaacac ctgcaatgcc ttgaggagga gctgaagccc      900

ctggaggagg tactgaacct ggcccagagc aagaactttc atctgaggcc cagggacctg      960

attagcaaca tcaacgtgat cgtgttggag ttgaagggca gcgagaccac gttcatgtgc     1020

gagtacgccg acgagacggc caccatagtg gagtttctta acaggtggat caccttctca     1080

cagtctatca tcagcaccct gacc                                            1104


<210>  185
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_mutIL15

<400>  185

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
225                 230                 235                 240 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                245                 250                 255     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            260                 265                 270         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        275                 280                 285             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    290                 295                 300                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
305                 310                 315                 320 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                325                 330                 335     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            340                 345                 


<210>  186
<211>  1047
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_mutIL15

<400>  186
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

aaggagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctga agtccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagcaattg ggtgaacgtg      720

atttctgact tgaagaaaat cgaggacttg attcaaagta tgcacataga cgcaacgctc      780

tatactgaga gtgatgttca tccctcttgt aaagttaccg ctatgaagtg tttcttgctc      840

gaactccaag ttatcagtct ggagagcggt gatgcctcca tacacgatac agtcgaaaac      900

cttatcattc tcgcaaataa ctcattgagt agcaatggca atgttacaga gtctgggtgt      960

aaggaatgcg aagaacttga agagaaaaac ataaaggagt tcctccaatc attcgtgcat     1020

attgtccaga tgtttatcaa cactagc                                         1047


<210>  187
<211>  412
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP2.S2_Fc1

<400>  187

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Leu Met Arg Ile Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        195                 200                 205             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    210                 215                 220                 


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
225                 230                 235                 240 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                245                 250                 255     


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            260                 265                 270         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        275                 280                 285             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    290                 295                 300                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
305                 310                 315                 320 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                325                 330                 335     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            340                 345                 350         


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        355                 360                 365             


Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    370                 375                 380                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
385                 390                 395                 400 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410         


<210>  188
<211>  1236
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2.S2_Fc1

<400>  188
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactctga tgaggatttg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540

gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg      600

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      660

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      720

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      780

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      840

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      900

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      960

gacgagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct     1020

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactatga cactaccccg     1080

cccgtgctgg attccgacgg aagcttcttc ctgtactccg acctgaccgt ggacaagtcg     1140

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac     1200

tacacccaga agtcactgag cctctccccc ggaaag                               1236


<210>  189
<211>  412
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide ULBP2.S3_Fc1

<400>  189

Glu Pro His Ser Leu Ser Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg 
1               5                   10                  15      


Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr 
            20                  25                  30          


Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro 
        35                  40                  45              


Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro 
    50                  55                  60                  


Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu Trp Asp Ile 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg 
                85                  90                  95      


Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg 
        115                 120                 125             


Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Asn Asp Lys Val Val Ala Thr Lys Leu Tyr Leu Trp Ser Met Gly 
145                 150                 155                 160 


Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr 
                165                 170                 175     


Leu Glu Pro Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        195                 200                 205             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    210                 215                 220                 


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
225                 230                 235                 240 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                245                 250                 255     


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            260                 265                 270         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        275                 280                 285             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    290                 295                 300                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
305                 310                 315                 320 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                325                 330                 335     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            340                 345                 350         


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        355                 360                 365             


Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    370                 375                 380                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
385                 390                 395                 400 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410         


<210>  190
<211>  1236
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding ULBP2.S3_Fc1

<400>  190
gagccccata gtctgagcta cgacatcaca gttattccca agttcaggcc cggaccgcgc       60

tggtgtgccg tgcaaggaca agtcgacgaa aaaacctttc ttcattacga ttgcggaaat      120

aagactgtaa cgccagtctc tcctttaggt aagaagttaa acgtcactac ggcgtggaag      180

gcacaaaacc ccgtcctgcg cgaggtcgtc gacatcctga ctgaacaatt gtgggacatc      240

cagctcgaga attacactcc aaaggagcct cttaccctgc aggctagaat gtcttgcgag      300

caaaaggcag agggccactc ctccggcagc tggcagttca gtttcgacgg acaaatcttt      360

ctgttattcg attcagagaa gagaatgtgg actacagttc accccggtgc ccgtaaaatg      420

aaggagaagt gggaaaacga caaagtggtg gcgactaagc tttatctttg gtcgatggga      480

gactgcatcg gttggctgga agatttcctc atgggtatgg actccacttt ggagccatcg      540

gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg      600

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      660

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      720

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      780

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      840

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      900

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      960

gacgagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct     1020

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactatga cactaccccg     1080

cccgtgctgg attccgacgg aagcttcttc ctgtactccg acctgaccgt ggacaagtcg     1140

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac     1200

tacacccaga agtcactgag cctctccccc ggaaag                               1236


<210>  191
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_wtIL2 (wild-type)

<400>  191

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
225                 230                 235                 240 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
                245                 250                 255     


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
            260                 265                 270         


Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
        275                 280                 285             


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
    290                 295                 300                 


Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
305                 310                 315                 320 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
                325                 330                 335     


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
            340                 345                 350         


Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu Thr 
        355                 360                 365             


<210>  192
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_wtIL2

<400>  192
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

aaggagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctga agtccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagcgctcc aacctctagc      720

tctacgaaga aaactcaact ccagcttgag catttgcttt tggaccttca aatgatattg      780

aacgggatta acaattacaa gaaccccaaa ctgacgcgaa tgcttacatt caaattttac      840

atgccaaaga aggccaccga gctgaaacac ttgcaatgtc ttgaggaaga gctgaagcca      900

ttggaggagg tcctgaattt ggctcaaagt aagaacttcc acctgcggcc aagggatctc      960

ataagcaaca taaatgtcat tgtattggaa ctgaaaggga gcgaaaccac ctttatgtgc     1020

gagtatgcag atgaaactgc aaccatagtc gagttcctca atcgctggat aactttcgcg     1080

cagtcaatta tatcaacact cacc                                            1104


<210>  193
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_IL21.wt (wild-type)

<400>  193

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gln Gly Gln Asp Arg 
225                 230                 235                 240 


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
                245                 250                 255     


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
            260                 265                 270         


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
        275                 280                 285             


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
    290                 295                 300                 


Leu Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
305                 310                 315                 320 


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
                325                 330                 335     


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
            340                 345                 350         


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
        355                 360                 365             


<210>  194
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_IL21.wt (wild-type)

<400>  194
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

aaggagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctga agtccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagccaggg tcaagaccgc      720

catatgatcc gaatgcgaca gctcattgat attgtcgatc aattgaaaaa ttacgtgaat      780

gatcttgtac cggagttcct ccccgcaccg gaggacgttg aaacgaattg tgagtggtca      840

gcattttctt gctttcagaa ggctcaactc aagagtgcaa acacgggtaa caacgagcgc      900

attatcaatg ttctcatcaa aaagctgaaa cgaaaaccgc ctagcaccaa cgcaggcaga      960

cgacagaagc accggctcac gtgcccaagt tgcgattctt atgagaaaaa gccaccgaaa     1020

gaattcctgg agcggttcaa gtccctcttg cagaaaatga ttcatcagca tctctccagc     1080

aggacacacg gctccgagga ctcc                                            1104


<210>  195
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_IL21.D18A

<400>  195

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gln Gly Gln Asp Arg 
225                 230                 235                 240 


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Ala Gln Leu Lys 
                245                 250                 255     


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
            260                 265                 270         


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
        275                 280                 285             


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
    290                 295                 300                 


Leu Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
305                 310                 315                 320 


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
                325                 330                 335     


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
            340                 345                 350         


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
        355                 360                 365             


<210>  196
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_IL21.D18A

<400>  196
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

aaggagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctga agtccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagccaggg tcaagaccgc      720

catatgatcc gaatgcgaca gctcattgat attgtcgcac aattgaaaaa ttacgtgaat      780

gatcttgtac cggagttcct ccccgcaccg gaggacgttg aaacgaattg tgagtggtca      840

gcattttctt gctttcagaa ggctcaactc aagagtgcaa acacgggtaa caacgagcgc      900

attatcaatg ttctcatcaa aaagctgaaa cgaaaaccgc ctagcaccaa cgcaggcaga      960

cgacagaagc accggctcac gtgcccaagt tgcgattctt atgagaaaaa gccaccgaaa     1020

gaattcctgg agcggttcaa gtccctcttg cagaaaatga ttcatcagca tctctccagc     1080

aggacacacg gctccgagga ctcc                                            1104


<210>  197
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_IL21.E109R

<400>  197

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gln Gly Gln Asp Arg 
225                 230                 235                 240 


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
                245                 250                 255     


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
            260                 265                 270         


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
        275                 280                 285             


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
    290                 295                 300                 


Leu Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
305                 310                 315                 320 


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
                325                 330                 335     


Lys Pro Pro Lys Glu Phe Leu Arg Arg Phe Lys Ser Leu Leu Gln Lys 
            340                 345                 350         


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
        355                 360                 365             


<210>  198
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_IL21.E109R

<400>  198
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

aaggagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctga agtccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagccaggg tcaagaccgc      720

catatgatcc gaatgcgaca gctcattgat attgtcgatc aattgaaaaa ttacgtgaat      780

gatcttgtac cggagttcct ccccgcaccg gaggacgttg aaacgaattg tgagtggtca      840

gcattttctt gctttcagaa ggctcaactc aagagtgcaa acacgggtaa caacgagcgc      900

attatcaatg ttctcatcaa aaagctgaaa cgaaaaccgc ctagcaccaa cgcaggcaga      960

cgacagaagc accggctcac gtgcccaagt tgcgattctt atgagaaaaa gccaccgaaa     1020

gaattcctgc ggcggttcaa gtccctcttg cagaaaatga ttcatcagca tctctccagc     1080

aggacacacg gctccgagga ctcc                                            1104


<210>  199
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2_IL21.D18A.E109R

<400>  199

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gln Gly Gln Asp Arg 
225                 230                 235                 240 


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Ala Gln Leu Lys 
                245                 250                 255     


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
            260                 265                 270         


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
        275                 280                 285             


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
    290                 295                 300                 


Leu Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
305                 310                 315                 320 


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
                325                 330                 335     


Lys Pro Pro Lys Glu Phe Leu Arg Arg Phe Lys Ser Leu Leu Gln Lys 
            340                 345                 350         


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
        355                 360                 365             


<210>  200
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2_IL21.D18A.E109R

<400>  200
gagcccaaaa gctgcgacaa gactcacact tgtccgccgt gccccgcccc cgaactgctg       60

ggtggcccct ccgtgttcct gttcccgcct aagcctaagg acacccttat gatcagccgc      120

acccctgaag tgacctgtgt cgtcgtggca gtgtcacacg aggacccgga ggtcaagttc      180

aattggtacg tggacggcgt ggaagtgcat aacgcaaaga ccaagcctcg ggaggaacag      240

tacgcctcga cctaccgcgt ggtgtcagtc ctgactgtgc tgcaccagga ctggctgaac      300

gggaaggagt acaagtgcaa agtgtcgaac aaggccctgc cggctccaat tgaaaagacc      360

atcagcaagg ccaagggcca gccaagggaa ccacaggtgt acaccctccc tccttcccgg      420

gacgagctga ccaaaaacca agtgtccctg acttgccttg tgaaggggtt ctacccttct      480

gacattgccg tcgaatggga atcgaacgga cagcctgaaa acaactataa gactaccccg      540

cccgtgctgg attccgacgg aagcttcttc ctgtactcca agctgaccgt ggacaagtcg      600

agatggcagc agggaaatgt gttcagctgc tccgtgatgc atgaggcgct gcacaaccac      660

tacacccaga agtcactgag cctctccccc ggaggaggtg gcagccaggg tcaagaccgc      720

catatgatcc gaatgcgaca gctcattgat attgtcgcac aattgaaaaa ttacgtgaat      780

gatcttgtac cggagttcct ccccgcaccg gaggacgttg aaacgaattg tgagtggtca      840

gcattttctt gctttcagaa ggctcaactc aagagtgcaa acacgggtaa caacgagcgc      900

attatcaatg ttctcatcaa aaagctgaaa cgaaaaccgc ctagcaccaa cgcaggcaga      960

cgacagaagc accggctcac gtgcccaagt tgcgattctt atgagaaaaa gccaccgaaa     1020

gaattcctgc ggcggttcaa gtccctcttg cagaaaatga ttcatcagca tctctccagc     1080

aggacacacg gctccgagga ctcc                                            1104


<210>  201
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide Fc2

<400>  201

Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  202
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide, encoding Fc2

<400>  202
atggacccca aaagctgcga caagactcac acttgtccgc cgtgccccgc ccccgaactg       60

ctgggtggcc cctccgtgtt cctgttcccg cctaagccta aggacaccct tatgatcagc      120

cgcacccctg aagtgacctg tgtcgtcgtg gcagtgtcac acgaggaccc ggaggtcaag      180

ttcaattggt acgtggacgg cgtggaagtg cataacgcaa agaccaagcc tcgggaggaa      240

cagtacgcct cgacctaccg cgtggtgtca gtcctgactg tgctgcacca ggactggctg      300

aacgggaagg agtacaagtg caaagtgtcg aacaaggccc tgccggctcc aattgaaaag      360

accatcagca aggccaaggg ccagccaagg gaaccacagg tgtacaccct ccctccttcc      420

cggaaggagc tgaccaaaaa ccaagtgtcc ctgacttgcc ttgtgaaggg gttctaccct      480

tctgacattg ccgtcgaatg ggaatcgaac ggacagcctg aaaacaacta taagactacc      540

ccgcccgtgc tgaagtccga cggaagcttc ttcctgtact ccaagctgac cgtggacaag      600

tcgagatggc agcagggaaa tgtgttcagc tgctccgtga tgcatgaggc gctgcacaac      660

cactacaccc agaagtcact gagcctctcc cccggaaag                             699


