                               SEQUENCE LISTING

<110> SANGAMO THERAPEUTICS, INC.
 
<120> IDENTIFICATION OF MOLECULES FOR INHIBITION OF NK-MEDIATED CELL 
      KILLING

<130> 8325-0186.40

<140> PCT/US2019/060045
<141> 2019-11-06

<150> 62/756,411> 
<151> 2018-11-06

<160> 21    

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Val Met Ala Pro Arg Thr Leu Phe Leu 
1               5                   


<210> 2
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Val Ala Pro Trp Asn Ser Phe Ala Leu 
1               5                   


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Arg Gly Pro Pro Gln Arg Pro Lys Leu 
1               5                   


<210> 4
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      'LAGLIDADG' family motif peptide

<400> 4
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 5
<211> 592
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210> 6
<211> 424
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
gatatcattg gtcaattgca gcagacatgt ctcttgtggt gtaaagcctc atagcatctt       60

cctgctggag tccacctggc agcccaaagc ctcagcaagt gctggggaca gagagataga      120

aaggctttgc tgtggctcaa ctcagttgta ctttctcaag ctccttttgg ttatctgctc      180

tgtctatgta gttgcttcct ggaaaatggt taaagtcaaa cctcctctgt ttggggcagc      240

acaaaatgtt gctaaggcgt tagaagacaa cataggagca gttaaaccac agccagtttt      300

tgctcgcttt cgaaagacca cagctattag acagaaaacc tcctgtactg gaagtggccc      360

tgaaacagca tctgtgctga cagacactgg gcttgctatg gttgctgctc atcatgctca      420

gctg                                                                   424


<210> 7
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ctcccatttc catgacgtca tggttaaacc tcttttacct gctttaaccc tttgaagctc       60

tcccgcagaa gccacatcct ctg                                               83


<210> 8
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu 
    210                 215                 220                 


Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met 
        435                 440                 445             


Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala 
    450                 455                 460                 


Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
465                 470                 475         


<210> 9
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met 
        195                 200                 205             


Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp 
    210                 215                 220                 


Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn 
225                 230                 235                 240 


Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly Arg Phe 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu 
                325                 330                 335     


Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly 
    370                 375                 380                 


Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val 
        435                 440                 445             


Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala 
    450                 455                 460                 


Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly 
465                 470                 475                 480 


Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu 
                485                 490                 495     


Ser His Ser Leu 
            500 


<210> 10
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu 
    210                 215                 220                 


Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Ala Asn 
225                 230                 235                 240 


Leu Ala Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met 
        435                 440                 445             


Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala 
    450                 455                 460                 


Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
465                 470                 475         


<210> 11
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Ala Pro Trp Asn Ser Phe Ala Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu 
    210                 215                 220                 


Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met 
        435                 440                 445             


Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala 
    450                 455                 460                 


Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
465                 470                 475         


<210> 12
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Arg Gly Pro Pro Gln Arg Pro Lys Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu 
    210                 215                 220                 


Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met 
        435                 440                 445             


Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala 
    450                 455                 460                 


Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
465                 470                 475         


<210> 13
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Ala Pro Trp Asn Ser Phe Ala Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu 
    210                 215                 220                 


Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Ala Asn 
225                 230                 235                 240 


Leu Ala Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met 
        435                 440                 445             


Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala 
    450                 455                 460                 


Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
465                 470                 475         


<210> 14
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Arg Gly Pro Pro Gln Arg Pro Lys Leu Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu 
    210                 215                 220                 


Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Ala Asn 
225                 230                 235                 240 


Leu Ala Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His 
                245                 250                 255     


Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu 
            260                 265                 270         


Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala 
        275                 280                 285             


Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
    290                 295                 300                 


Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
            340                 345                 350         


Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro 
            420                 425                 430         


Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met 
        435                 440                 445             


Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala 
    450                 455                 460                 


Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
465                 470                 475         


<210> 15
<211> 323
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210> 16
<211> 1745> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
tccacggggt tggggttgcg ccttttccaa ggcagccctg ggtttgcgca gggacgcggc       60

tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc      120

acgtccgttc gcagcgtcac ccggatcttc gccgctaccc ttgtgggccc cccggcgacg      180

cttcctgctc cgcccctaag tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga      240

caaacggaag ccgcacgtct cactagtacc ctcgcagacg gacagcgcca gggagcaatg      300

gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct gctcagcagg gcgcgccgag      360

agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg      420

ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc      480

tccctcgttg accgaatcac cgacctctct ccccaggggg atcctctgcc gccaccatgt      540

ggccactcgt cgccgcctta cttcttggat cagcttgctg tggatcagcc caactcctct      600

ttaacaagac caagtccgtg gagttcactt tctgcaacga caccgtggtc atcccgtgct      660

tcgtgactaa catggaagcg cagaacacca ctgaagtcta cgtgaagtgg aagttcaagg      720

gtcgcgatat ctatacgttt gacggcgccc tgaacaagtc caccgtgccc accgacttct      780

cgtccgcgaa gattgaagtg tcccagctgc tgaagggcga cgctagcctg aagatggata      840

agagcgacgc cgtgtctcac accgggaact acacctgtga agtgaccgag ctcactcgcg      900

agggcgaaac catcatcgag ctgaaatacc gggtcgtgtc ctggttctcc ccgaacgaaa      960

acatcctgat cgtgattttc cctatcttcg ccatcctgtt gttctgggga cagttcggca     1020

tcaagaccct gaagtacaga agcggcggaa tggacgaaaa gaccattgca ctcctggtgg     1080

ccggtttggt gatcactgtg atcgtgatcg tgggagcgat tctgtttgtg ccgggagagt     1140

actcgctcaa aaatgccacc ggtctgggac tgatcgtgac tagcaccggg atactcattc     1200

tgctgcatta ctacgtgttc tcgactgcca tcggcctcac ctccttcgtg attgccatcc     1260

tggtcatcca agtcattgcc tacatcctcg ccgtggtcgg actgagcctg tgcattgccg     1320

cgtgcatccc tatgcacggg ccccttttga tttccggact gtccattctg gcactggctc     1380

agctgctggg cctggtgtac atgaaattcg tggcgtcgaa tcaaaagaca atccagcccc     1440

cgcggaaggc agtcgaggaa cctctgaacg ccttcaagga atccaagggg atgatgaacg     1500

atgagtgata gggggtcgac ctgtgccttc tagttgccag ccatctgttg tttgcccctc     1560

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     1620

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     1680

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     1740

tatgg                                                                 1745


<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Arg Gly Gly Pro Pro Gln Arg Pro Lys Leu 
1               5                   10  


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Gly Gly Gly Ser 
1               5   


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Arg Gly Pro Pro Gln Arg Lys Leu 
1               5               


