                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Frank, David
       Nelson, Erik
 
<120>  TARGETING THE TRANSCRIPTION FACTOR NF-KB WITH HARMINE

<130>  52095-547001WO

<140>  PCT/US19/60260
<141>  2019-11-07

<150>   US 62/757,314
<151>  2018-11-08

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  1
caggcatgaa ccaccgcgcc cggcctccaa taaacattta ttgggcacct acggtgttcc       60

aggcgctggt ctaggcgttg gggttacaac aacgcacaaa acataaattc tgaagctgac      120

acgctagctt taaacgttcc ttaaatatct tcatcctcaa tttacggttg aggaaactga      180

ggtgtagcga gaccttggag gtttccgaaa tattattatg gatggcaggt gtagagccct      240

gccaacctct                                                             250


<210>  2
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ser Cys Tyr Asn Pro Gly Leu Asp Gly Ile Ile Glu Tyr Asp 
1               5                   10                  15      


Asp Phe Lys Leu Asn Ser Ser Ile Val Glu Pro Lys Glu Pro Ala Pro 
            20                  25                  30          


Glu Thr Ala Asp Gly Pro Tyr Leu Val Ile Val Glu Gln Pro Lys Gln 
        35                  40                  45              


Arg Gly Phe Arg Phe Arg Tyr Gly Cys Glu Gly Pro Ser His Gly Gly 
    50                  55                  60                  


Leu Pro Gly Ala Ser Ser Glu Lys Gly Arg Lys Thr Tyr Pro Thr Val 
65                  70                  75                  80  


Lys Ile Cys Asn Tyr Glu Gly Pro Ala Lys Ile Glu Val Asp Leu Val 
                85                  90                  95      


Thr His Ser Asp Pro Pro Arg Ala His Ala His Ser Leu Val Gly Lys 
            100                 105                 110         


Gln Cys Ser Glu Leu Gly Ile Cys Ala Val Ser Val Gly Pro Lys Asp 
        115                 120                 125             


Met Thr Ala Gln Phe Asn Asn Leu Gly Val Leu His Val Thr Lys Lys 
    130                 135                 140                 


Asn Met Met Gly Thr Met Ile Gln Lys Leu Gln Arg Gln Arg Leu Arg 
145                 150                 155                 160 


Ser Arg Pro Gln Gly Leu Thr Glu Ala Glu Gln Arg Glu Leu Glu Gln 
                165                 170                 175     


Glu Ala Lys Glu Leu Lys Lys Val Met Asp Leu Ser Ile Val Arg Leu 
            180                 185                 190         


Arg Phe Ser Ala Phe Leu Arg Ala Ser Asp Gly Ser Phe Ser Leu Pro 
        195                 200                 205             


Leu Lys Pro Val Thr Ser Gln Pro Ile His Asp Ser Lys Ser Pro Gly 
    210                 215                 220                 


Ala Ser Asn Leu Lys Ile Ser Arg Met Asp Lys Thr Ala Gly Ser Val 
225                 230                 235                 240 


Arg Gly Gly Asp Glu Val Tyr Leu Leu Cys Asp Lys Val Gln Lys Asp 
                245                 250                 255     


Asp Ile Glu Val Arg Phe Tyr Glu Asp Asp Glu Asn Gly Trp Gln Ala 
            260                 265                 270         


Phe Gly Asp Phe Ser Pro Thr Asp Val His Lys Gln Tyr Ala Ile Val 
        275                 280                 285             


Phe Arg Thr Pro Pro Tyr His Lys Met Lys Ile Glu Arg Pro Val Thr 
    290                 295                 300                 


Val Phe Leu Gln Leu Lys Arg Lys Arg Gly Gly Asp Val Ser Asp Ser 
305                 310                 315                 320 


Lys Gln Phe Thr Tyr Tyr Pro Leu Val Glu Asp Lys Glu Glu Val Gln 
                325                 330                 335     


Arg Lys Arg Arg Lys Ala Leu Pro Thr Phe Ser Gln Pro Phe Gly Gly 
            340                 345                 350         


Gly Ser His Met Gly Gly Gly Ser Gly Gly Ala Ala Gly Gly Tyr Gly 
        355                 360                 365             


Gly Ala Gly Gly Gly Glu Gly Val Leu Met Glu Gly Gly Val Lys Val 
    370                 375                 380                 


Arg Glu Ala Val Glu Glu Lys Asn Leu Gly Glu Ala Gly Arg Gly Leu 
385                 390                 395                 400 


His Ala Cys Asn Pro Ala Phe Gly Arg Pro Arg Gln Ala Val Thr 
                405                 410                 415 


<210>  3
<211>  3001
<212>  DNA
<213>  Homo sapiens

<400>  3
actttcctgc cccttccccg gccaagccca actccggatc tcgctctcca ccggatctca       60

cccgccacac ccggacaggc ggctggagga ggcgggcgtc taaaattctg ggaagcagaa      120

cctggccgga gccactagac agagccgggc ctagcccaga gacatggaga gttgctacaa      180

cccaggtctg gatggtatta ttgaatatga tgatttcaaa ttgaactcct ccattgtgga      240

acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc      300

taagcagaga ggcttccgat ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc      360

cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga      420

gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc      480

ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc      540

caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat      600

gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct      660

tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga      720

tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctccttctc      780

cctgcccctg aagccagtca cctcccagcc catccatgat agcaaatctc cgggggcatc      840

aaacctgaag atttctcgaa tggacaagac agcaggctct gtgcggggtg gagatgaagt      900

ttatctgctt tgtgacaagg tgcagaaaga tgacattgag gttcggttct atgaggatga      960

tgagaatgga tggcaggcct ttggggactt ctctcccaca gatgtgcata aacagtatgc     1020

cattgtgttc cggacacccc cctatcacaa gatgaagatt gagcggcctg taacagtgtt     1080

tctgcaactg aaacgcaagc gaggagggga cgtgtctgat tccaaacagt tcacctatta     1140

ccctctggtg gaagacaagg aagaggtgca gcggaagcgg aggaaggcct tgcccacctt     1200

ctcccagccc ttcgggggtg gctcccacat gggtggaggc tctgggggtg cagccggggg     1260

ctacggagga gctggaggag gtggcagcct cggtttcttc ccctcctccc tggcctacag     1320

cccctaccag tccggcgcgg gccccatgcg gtgctacccg ggaggcgggg gcggggcgca     1380

gatggccgcc acggtgccca gcagggactc cggggaggaa gccgcggagc cgagcgcccc     1440

ctccaggacc ccccagtgcg agccgcaggc cccggagatg ctgcagcgag ctcgagagta     1500

caacgcgcgc ctgttcggcc tggcgcacgc agccccgagc cctactcgac tactgcgtca     1560

ccgcggacgc cgcgcgctgc tggcgggaca gcgccacctg ctgacggcgc aggacgagaa     1620

cggagacaca ccactgcacc tagccatcat ccacgggcag accagtgtca ttgagcagat     1680

agtctatgtc atccaccacg cccaggacct cggcgttgtc aacctcacca accacctgca     1740

ccagacgccc ctgcacctgg cggtgatcac ggggcagacg agtgtggtga gctttctgct     1800

gcgggtaggt gcagacccag ctctgctgga tcggcatgga gactcagcca tgcatctggc     1860

gctgcgggca ggcgctggtg ctcctgagct gctgcgtgca ctgcttcaga gtggagctcc     1920

tgctgtgccc cagctgttgc atatgcctga ctttgaggga ctgtatccag tacacctggc     1980

ggtccgagcc cgaagccctg agtgcctgga tctgctggtg gacagtgggg ctgaagtgga     2040

ggccacagag cggcaggggg gacgaacagc cttgcatcta gccacagaga tggaggagct     2100

ggggttggtc acccatctgg tcaccaagct ccgggccaac gtgaacgctc gcacctttgc     2160

gggaaacaca cccctgcacc tggcagctgg actggggtac ccgaccctca cccgcctcct     2220

tctgaaggct ggtgctgaca tccatgctga aaacgaggag cccctgtgcc cactgccttc     2280

accccctacc tctgatagcg actcggactc tgaagggcct gagaaggaca cccgaagcag     2340

cttccggggc cacacgcctc ttgacctcac ttgcagcacc ttggtgaaga ccttgctgct     2400

aaatgctgct cagaacacca tggagccacc cctgaccccg cccagcccag cagggccggg     2460

actgtcactt ggtgatacag ctctgcagaa cctggagcag ctgctagacg ggccagaagc     2520

ccagggcagc tgggcagagc tggcagagcg tctggggctg cgcagcctgg tagacacgta     2580

ccgacagaca acctcaccca gtggcagcct cctgcgcagc tacgagctgg ctggcgggga     2640

cctggcaggt ctactggagg ccctgtctga catgggccta gaggagggag tgaggctgct     2700

gaggggtcca gaaacccgag acaagctgcc cagcacagag gtgaaggaag acagtgcgta     2760

cgggagccag tcagtggagc aggaggcaga gaagctgggc ccaccccctg agccaccagg     2820

agggctctcg cacgggcacc cccagcctca ggtgactgac ctgctgcctg cccccagccc     2880

ccttcccgga ccccctgtac agcgtcccca cctatttcaa atcttattta acaccccaca     2940

cccacccctc agttgggaca aataaaggat tctcatggga aggggaggac cccgaattcc     3000

t                                                                     3001


<210>  4
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser 
1               5                   10                  15      


Ala Asn Thr Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg 
            20                  25                  30          


Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
        35                  40                  45              


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
    50                  55                  60                  


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Thr Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val 
                85                  90                  95      


Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Thr Ser Gln Pro Thr 
            100                 105                 110         


Phe Pro Ser Ser Val Thr Asn Ser Thr His Ser Leu Leu Pro Gly Thr 
        115                 120                 125             


Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn 
    130                 135                 140                 


Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser 
145                 150                 155                 160 


Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Thr Phe 
                165                 170                 175     


Gln Thr Trp Pro Leu Thr Phe Leu Ser Pro Thr Asp Leu Ala Lys Ala 
            180                 185                 190         


Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys 
        195                 200                 205             


Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu 
    210                 215                 220                 


His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln 
225                 230                 235                 240 


Asp Thr Ser Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala 
                245                 250                 255     


Ala Arg Phe Lys Thr Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn 
            260                 265                 270         


Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp 
        275                 280                 285             


Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser 
    290                 295                 300                 


Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu 
305                 310                 315                 320 


Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala 
                325                 330                 335     


Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Ser Pro 
            340                 345                 350         


Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu 
        355                 360                 365             


Asp His Ser Glu Asp Ala Ile Met Met Asn Thr Pro Val Ile Asn Ala 
    370                 375                 380                 


Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Thr Val Gln 
385                 390                 395                 400 


Arg Lys Ile Leu Ala Thr Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu 
                405                 410                 415     


Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg 
            420                 425                 430         


Glu Arg Ala Thr Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg 
        435                 440                 445             


Lys Asn Arg Met Ala Leu Phe Gln His Leu Thr Cys Val Ile Pro Ile 
    450                 455                 460                 


Leu Asp Ser Leu Leu Thr Ala Gly Ile Ile Asn Glu Gln Glu His Asp 
465                 470                 475                 480 


Val Ile Lys Gln Lys Thr Gln Thr Ser Leu Gln Ala Arg Glu Leu Ile 
                485                 490                 495     


Asp Thr Ile Leu Val Lys Gly Asn Ile Ala Ala Thr Val Phe Arg Asn 
            500                 505                 510         


Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln 
        515                 520                 525             


Gln Asp Ile Lys Tyr Ile Pro Thr Glu Asp Val Ser Asp Leu Pro Val 
    530                 535                 540                 


Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys 
545                 550                 555                 560 


Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val 
                565                 570                 575     


Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg 
            580                 585                 590         


Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
        595                 600                 


<210>  5
<211>  6932
<212>  DNA
<213>  Homo sapiens

<400>  5
gcatttaaaa gacagcgtga gactcgcgcc ctccggcacg gaaaaggcca ggcgacaggt       60

gtcgcttgaa aagactgggc ttgtccttgc tggtgcatgc gtcgtcggcc tctgggcagc      120

aggtttacaa aggaggaaaa cgacttcttc tagatttttt tttcagtttc ttctataaat      180

caaaacatct caaaatggag acctaaaatc cttaaaggga cttagtctaa tctcgggagg      240

tagttttgtg catgggtaaa caaattaagt attaactggt gttttactat ccaaagaatg      300

ctaattttat aaacatgatc gagttatata aggtatacca taatgagttt gattttgaat      360

ttgatttgtg gaaataaagg aaaagtgatt ctagctgggg catattgtta aagcattttt      420

ttcagagttg gccaggcagt ctcctactgg cacattctcc cattatgtag aatagaaata      480

gtacctgtgt ttgggaaaga ttttaaaatg agtgacagtt atttggaaca aagagctaat      540

aatcaatcca ctgcaaatta aagaaacatg cagatgaaag ttttgacaca ttaaaatact      600

tctacagtga caaagaaaaa tcaagaacaa agctttttga tatgtgcaac aaatttagag      660

gaagtaaaaa gataaatgtg atgattggtc aagaaattat ccagttattt acaaggccac      720

tgatatttta aacgtccaaa agtttgttta aatgggctgt taccgctgag aatgatgagg      780

atgagaatga tggttgaagg ttacatttta ggaaatgaag aaacttagaa aattaatata      840

aagacagtga tgaatacaaa gaagattttt ataacaatgt gtaaaatttt tggccaggga      900

aaggaatatt gaagttagat acaattactt acctttgagg gaaataattg ttggtaatga      960

gatgtgatgt ttctcctgcc acctggaaac aaagcattga agtctgcagt tgaaaagccc     1020

aacgtctgtg agatccagga aaccatgctt gcaaaccact ggtaaaaaaa aaaaaaaaaa     1080

aaaaaaaaag ccacagtgac ttgcttattg gtcattgcta gtattatcga ctcagaacct     1140

ctttactaat ggctagtaaa tcataattga gaaattctga attttgacaa ggtctctgct     1200

gttgaaatgg taaatttatt attttttttg tcatgataaa ttctggttca aggtatgcta     1260

tccatgaaat aatttctgac caaaactaaa ttgatgcaat ttgattatcc atcttagcct     1320

acagatggca tctggtaact tttgactgtt ttaaaaaata aatccactat cagagtagat     1380

ttgatgttgg cttcagaaac atttagaaaa acaaaagttc aaaaatgttt tcaggaggtg     1440

ataagttgaa taactctaca atgttagttc tttgaggggg acaaaaaatt taaaatcttt     1500

gaaaggtctt attttacagc catatctaaa ttatcttaag aaaattttta acaaagggaa     1560

tgaaatatat atcatgattc tgtttttcca aaagtaacct gaatatagca atgaagttca     1620

gttttgttat tggtagtttg ggcagagtct ctttttgcag cacctgttgt ctaccataat     1680

tacagaggac atttccatgt tctagccaag tatactatta gaataaaaaa acttaacatt     1740

gagttgcttc aacagcatga aactgagtcc aaaagaccaa atgaacaaac acattaatct     1800

ctgattattt attttaaata gaatatttaa ttgtgtaaga tctaatagta tcattatact     1860

taagcaatca tattcctgat gatctatggg aaataactat tatttaatta atattgaaac     1920

caggttttaa gatgtgttag ccagtcctgt tactagtaaa tctctttatt tggagagaaa     1980

ttttagattg ttttgttctc cttattagaa ggattgtaga aagaaaaaaa tgactaattg     2040

gagaaaaatt ggggatatat catatttcac tgaattcaaa atgtcttcag ttgtaaatct     2100

taccattatt ttacgtacct ctaagaaata aaagtgcttc taattaaaat atgatgtcat     2160

taattatgaa atacttcttg ataacagaag ttttaaaata gccatcttag aatcagtgaa     2220

atatggtaat gtattatttt cctcctttga gttaggtctt gtgctttttt ttcctggcca     2280

ctaaatttca caatttccaa aaagcaaaat aaacatattc tgaatatttt tgctgtgaaa     2340

cacttgacag cagagctttc caccatgaaa agaagcttca tgagtcacac attacatctt     2400

tgggttgatt gaatgccact gaaacattct agtagcctgg agaagttgac ctacctgtgg     2460

agatgcctgc cattaaatgg catcctgatg gcttaataca catcactctt ctgtgaaggg     2520

ttttaatttt caacacagct tactctgtag catcatgttt acattgtatg tataaagatt     2580

atacaaaggt gcaattgtgt atttcttcct taaaatgtat cagtatagga tttagaatct     2640

ccatgttgaa actctaaatg catagaaata aaaataataa aaaatttttc attttggctt     2700

ttcagcctag tattaaaact gataaaagca aagccatgca caaaactacc tccctagaga     2760

aaggctagtc ccttttcttc cccattcatt tcattatgaa catagtagaa aacagcatat     2820

tcttatcaaa tttgatgaaa agcgccaaca cgtttgaact gaaatacgac ttgtcatgtg     2880

aactgtaccg aatgtctacg tattccactt ttcctgctgg ggttcctgtc tcagaaagga     2940

gtcttgctcg tgctggtttc tattacactg gtgtgaatga caaggtcaaa tgcttctgtt     3000

gtggcctgat gctggataac tggaaaagag gagacagtcc tactgaaaag cataaaaagt     3060

tgtatcctag ctgcagattc gttcagagtc taaattccgt taacaacttg gaagctacct     3120

ctcagcctac ttttccttct tcagtaacaa attccacaca ctcattactt ccgggtacag     3180

aaaacagtgg atatttccgt ggctcttatt caaactctcc atcaaatcct gtaaactcca     3240

gagcaaatca agatttttct gccttgatga gaagttccta ccactgtgca atgaataacg     3300

aaaatgccag attacttact tttcagacat ggccattgac ttttctgtcg ccaacagatc     3360

tggcaaaagc aggcttttac tacataggac ctggagacag agtggcttgc tttgcctgtg     3420

gtggaaaatt gagcaattgg gaaccgaagg ataatgctat gtcagaacac ctgagacatt     3480

ttcccaaatg cccatttata gaaaatcagc ttcaagacac ttcaagatac acagtttcta     3540

atctgagcat gcagacacat gcagcccgct ttaaaacatt ctttaactgg ccctctagtg     3600

ttctagttaa tcctgagcag cttgcaagtg cgggttttta ttatgtgggt aacagtgatg     3660

atgtcaaatg cttttgctgt gatggtggac tcaggtgttg ggaatctgga gatgatccat     3720

gggttcaaca tgccaagtgg tttccaaggt gtgagtactt gataagaatt aaaggacagg     3780

agttcatccg tcaagttcaa gccagttacc ctcatctact tgaacagctg ctatccacat     3840

cagacagccc aggagatgaa aatgcagagt catcaattat ccattttgaa cctggagaag     3900

accattcaga agatgcaatc atgatgaata ctcctgtgat taatgctgcc gtggaaatgg     3960

gctttagtag aagcctggta aaacagacag ttcagagaaa aatcctagca actggagaga     4020

attatagact agtcaatgat cttgtgttag acttactcaa tgcagaagat gaaataaggg     4080

aagaggagag agaaagagca actgaggaaa aagaatcaaa tgatttatta ttaatccgga     4140

agaatagaat ggcacttttt caacatttga cttgtgtaat tccaatcctg gatagtctac     4200

taactgccgg aattattaat gaacaagaac atgatgttat taaacagaag acacagacgt     4260

ctttacaagc aagagaactg attgatacga ttttagtaaa aggaaatatt gcagccactg     4320

tattcagaaa ctctctgcaa gaagctgaag ctgtgttata tgagcattta tttgtgcaac     4380

aggacataaa atatattccc acagaagatg tttcagatct accagtggaa gaacaattgc     4440

ggagactaca agaagaaaga acatgtaaag tgtgtatgga caaagaagtg tccatagtgt     4500

ttattccttg tggtcatcta gtagtatgca aagattgtgc tccttcttta agaaagtgtc     4560

ctatttgtag gagtacaatc aagggtacag ttcgtacatt tctttcatga agaagaacca     4620

aaacatcgtc taaactttag aattaattta ttaaatgtat tataacttta acttttatcc     4680

taatttggtt tccttaaaat ttttatttat ttacaactca aaaaacattg ttttgtgtaa     4740

catatttata tatgtatcta aaccatatga acatatattt tttagaaact aagagaatga     4800

taggcttttg ttcttatgaa cgaaaaagag gtagcactac aaacacaata ttcaatcaaa     4860

atttcagcat tattgaaatt gtaagtgaag taaaacttaa gatatttgag ttaaccttta     4920

agaattttaa atattttggc attgtactaa taccgggaac atgaagccag gtgtggtggt     4980

atgtgcctgt agtcccaggc tgaggcaaga gaattacttg agcccaggag tttgaatcca     5040

tcctgggcag catactgaga ccctgccttt aaaaacaaac agaacaaaaa caaaacacca     5100

gggacacatt tctctgtctt ttttgatcag tgtcctatac atcgaaggtg tgcatatatg     5160

ttgaatgaca ttttagggac atggtgtttt tataaagaat tctgtgagaa aaaatttaat     5220

aaagcaacaa aaattactct tattcttcat tgctttattt caatgacatt ggatagttta     5280

gtcactccca gactctttcc ataccttctt aaagcctctc aaatattgaa ctacagttta     5340

tactccttcc cataagatgc ttcttcattg acacttgtag aacacggggt caacacatca     5400

taaaatctat tatggaatgc ctgagacaag aatcaaacag tccctttagt aagtttgttt     5460

attcacttct ctattgattc attcaagaag tctcatgcca gccccaccta ttggaagaag     5520

gtctgagttt tattcttatc tctttggtat taattctgaa acttagaaag tacactggtt     5580

agcaatgctt gggaccaaca ggttgttctg gtaaataaat ctgtttcata ttgtcagtgc     5640

aacaaaatgt ccccctctgc attatgttat tggtactcaa cacgtccgag tcataactct     5700

gtcctttgct tcttatagag gtattaggtc ttcaagagca gaagtaagac tgtaataggg     5760

aatactcagg ggaaggcagg caaaggctag tcatctaaac cagttctaga tgtctgtata     5820

ggggcagatg gctctgtaag ggcagaaggg aaagacccct tcataagggt cacagctgac     5880

aatcctataa caaaagacag gttaacaaga gaaaaactta acaaatttat ttaatcacag     5940

atttacatca ccggggagcc ttcgtaatga agatccaaaa ttacagggga aactgtgcat     6000

ttttatgctt aggtttgata atgaatggac agccctgaag aatagtgatt ggaaaaaaag     6060

gatatgatct aatgggaata gacacaggtt ggggacccag caaggcctgt ctgttcagat     6120

tattcttggt ctctgtgcag cattccttcc tcctggatat agggcagggc ctgtatggga     6180

tggggatatt ataacctgct atcaagcaag gtaggtcaga gaatttattt atggccagct     6240

cttacatagt taggtgagga aagattagag tactatcttt aagatgtaag tctggcattg     6300

tggaaagatg gttccagttt ctatgaccta ccttggggaa gaggaattca agtttctgtg     6360

gcttgccttc agggagaatg aggctgagac aggagggcag gataacatca gagaaaaact     6420

ttgcttctga ggccttcact ttgggttttc tgagccccaa catctgctag tgttgtaaag     6480

agaacaatta gggaccaagt gaggggagga aagaatccat ctctgcattc tgatgctggg     6540

agacttattt ccttgaaatg caattgattt tgcctctgct aagaggctct gctggctacc     6600

catgtactag ccagtgtcct gcatgggtgc taggctgaat tatttgtaat tgtgcttagg     6660

tgatttgtaa ctcaggtata gggtatttaa atagtaggca ccctttttgc accatgtgtt     6720

ttttttttta tctagttctt gtatactaca gataatattt gaactttgtc atctcactgt     6780

aaaacttttg ttcatttctc attatggtaa taaatagcta ttataaccaa cccatttatt     6840

caaatatgtt atttccctaa gtgttatttt gacattttgt tttggaaaaa ataaatcacc     6900

atagataata aaaaaaaaaa aaaaaaaaaa aa                                   6932


<210>  6
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  7
<211>  1605
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ala Ala Gly Ala Ala Ala Cys Cys Ala Cys Cys Gly Gly Ala Ala 
1               5                   10                  15      


Gly Gly Ala Ala Cys Cys Ala Thr Cys Thr Cys Ala Cys Thr Gly Thr 
            20                  25                  30          


Gly Thr Gly Thr Ala Ala Ala Cys Ala Thr Gly Ala Cys Thr Thr Cys 
        35                  40                  45              


Cys Ala Ala Gly Cys Thr Gly Gly Cys Cys Gly Thr Gly Gly Cys Thr 
    50                  55                  60                  


Cys Thr Cys Thr Thr Gly Gly Cys Ala Gly Cys Cys Thr Thr Cys Cys 
65                  70                  75                  80  


Thr Gly Ala Thr Thr Thr Cys Thr Gly Cys Ala Gly Cys Thr Cys Thr 
                85                  90                  95      


Gly Thr Gly Thr Gly Ala Ala Gly Gly Thr Gly Cys Ala Gly Thr Thr 
            100                 105                 110         


Thr Thr Gly Cys Cys Ala Ala Gly Gly Ala Gly Thr Gly Cys Thr Ala 
        115                 120                 125             


Ala Ala Gly Ala Ala Cys Thr Thr Ala Gly Ala Thr Gly Thr Cys Ala 
    130                 135                 140                 


Gly Thr Gly Cys Ala Thr Ala Ala Ala Gly Ala Cys Ala Thr Ala Cys 
145                 150                 155                 160 


Thr Cys Cys Ala Ala Ala Cys Cys Thr Thr Thr Cys Cys Ala Cys Cys 
                165                 170                 175     


Cys Cys Ala Ala Ala Thr Thr Thr Ala Thr Cys Ala Ala Ala Gly Ala 
            180                 185                 190         


Ala Cys Thr Gly Ala Gly Ala Gly Thr Gly Ala Thr Thr Gly Ala Gly 
        195                 200                 205             


Ala Gly Thr Gly Gly Ala Cys Cys Ala Cys Ala Cys Thr Gly Cys Gly 
    210                 215                 220                 


Cys Cys Ala Ala Cys Ala Cys Ala Gly Ala Ala Ala Thr Thr Ala Thr 
225                 230                 235                 240 


Thr Gly Thr Ala Ala Ala Gly Cys Thr Thr Thr Cys Thr Gly Ala Thr 
                245                 250                 255     


Gly Gly Ala Ala Gly Ala Gly Ala Gly Cys Thr Cys Thr Gly Thr Cys 
            260                 265                 270         


Thr Gly Gly Ala Cys Cys Cys Cys Ala Ala Gly Gly Ala Ala Ala Ala 
        275                 280                 285             


Cys Thr Gly Gly Gly Thr Gly Cys Ala Gly Ala Gly Gly Gly Thr Thr 
    290                 295                 300                 


Gly Thr Gly Gly Ala Gly Ala Ala Gly Thr Thr Thr Thr Thr Gly Ala 
305                 310                 315                 320 


Ala Gly Ala Gly Gly Gly Cys Thr Gly Ala Gly Ala Ala Thr Thr Cys 
                325                 330                 335     


Ala Thr Ala Ala Ala Ala Ala Ala Ala Thr Thr Cys Ala Thr Thr Cys 
            340                 345                 350         


Thr Cys Thr Gly Thr Gly Gly Thr Ala Thr Cys Cys Ala Ala Gly Ala 
        355                 360                 365             


Ala Thr Cys Ala Gly Thr Gly Ala Ala Gly Ala Thr Gly Cys Cys Ala 
    370                 375                 380                 


Gly Thr Gly Ala Ala Ala Cys Thr Thr Cys Ala Ala Gly Cys Ala Ala 
385                 390                 395                 400 


Ala Thr Cys Thr Ala Cys Thr Thr Cys Ala Ala Cys Ala Cys Thr Thr 
                405                 410                 415     


Cys Ala Thr Gly Thr Ala Thr Thr Gly Thr Gly Thr Gly Gly Gly Thr 
            420                 425                 430         


Cys Thr Gly Thr Thr Gly Thr Ala Gly Gly Gly Thr Thr Gly Cys Cys 
        435                 440                 445             


Ala Gly Ala Thr Gly Cys Ala Ala Thr Ala Cys Ala Ala Gly Ala Thr 
    450                 455                 460                 


Thr Cys Cys Thr Gly Gly Thr Thr Ala Ala Ala Thr Thr Thr Gly Ala 
465                 470                 475                 480 


Ala Thr Thr Thr Cys Ala Gly Thr Ala Ala Ala Cys Ala Ala Thr Gly 
                485                 490                 495     


Ala Ala Thr Ala Gly Thr Thr Thr Thr Thr Cys Ala Thr Thr Gly Thr 
            500                 505                 510         


Ala Cys Cys Ala Thr Gly Ala Ala Ala Thr Ala Thr Cys Cys Ala Gly 
        515                 520                 525             


Ala Ala Cys Ala Thr Ala Cys Thr Thr Ala Thr Ala Thr Gly Thr Ala 
    530                 535                 540                 


Ala Ala Gly Thr Ala Thr Thr Ala Thr Thr Thr Ala Thr Thr Thr Gly 
545                 550                 555                 560 


Ala Ala Thr Cys Thr Ala Cys Ala Ala Ala Ala Ala Ala Cys Ala Ala 
                565                 570                 575     


Cys Ala Ala Ala Thr Ala Ala Thr Thr Thr Thr Thr Ala Ala Ala Thr 
            580                 585                 590         


Ala Thr Ala Ala Gly Gly Ala Thr Thr Thr Thr Cys Cys Thr Ala Gly 
        595                 600                 605             


Ala Thr Ala Thr Thr Gly Cys Ala Cys Gly Gly Gly Ala Gly Ala Ala 
    610                 615                 620                 


Thr Ala Thr Ala Cys Ala Ala Ala Thr Ala Gly Cys Ala Ala Ala Ala 
625                 630                 635                 640 


Thr Thr Gly Ala Gly Gly Cys Cys Ala Ala Gly Gly Gly Cys Cys Ala 
                645                 650                 655     


Ala Gly Ala Gly Ala Ala Thr Ala Thr Cys Cys Gly Ala Ala Cys Thr 
            660                 665                 670         


Thr Thr Ala Ala Thr Thr Thr Cys Ala Gly Gly Ala Ala Thr Thr Gly 
        675                 680                 685             


Ala Ala Thr Gly Gly Gly Thr Thr Thr Gly Cys Thr Ala Gly Ala Ala 
    690                 695                 700                 


Thr Gly Thr Gly Ala Thr Ala Thr Thr Thr Gly Ala Ala Gly Cys Ala 
705                 710                 715                 720 


Thr Cys Ala Cys Ala Thr Ala Ala Ala Ala Ala Thr Gly Ala Thr Gly 
                725                 730                 735     


Gly Gly Ala Cys Ala Ala Thr Ala Ala Ala Thr Thr Thr Thr Gly Cys 
            740                 745                 750         


Cys Ala Thr Ala Ala Ala Gly Thr Cys Ala Ala Ala Thr Thr Thr Ala 
        755                 760                 765             


Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys Cys Thr Gly Gly Ala Thr 
    770                 775                 780                 


Thr Thr Thr Thr Thr Thr Cys Thr Gly Thr Thr Ala Ala Ala Thr Cys 
785                 790                 795                 800 


Thr Gly Gly Cys Ala Ala Cys Cys Cys Thr Ala Gly Thr Cys Thr Gly 
                805                 810                 815     


Cys Thr Ala Gly Cys Cys Ala Gly Gly Ala Thr Cys Cys Ala Cys Ala 
            820                 825                 830         


Ala Gly Thr Cys Cys Thr Thr Gly Thr Thr Cys Cys Ala Cys Thr Gly 
        835                 840                 845             


Thr Gly Cys Cys Thr Thr Gly Gly Thr Thr Thr Cys Thr Cys Cys Thr 
    850                 855                 860                 


Thr Thr Ala Thr Thr Thr Cys Thr Ala Ala Gly Thr Gly Gly Ala Ala 
865                 870                 875                 880 


Ala Ala Ala Gly Thr Ala Thr Thr Ala Gly Cys Cys Ala Cys Cys Ala 
                885                 890                 895     


Thr Cys Thr Thr Ala Cys Cys Thr Cys Ala Cys Ala Gly Thr Gly Ala 
            900                 905                 910         


Thr Gly Thr Thr Gly Thr Gly Ala Gly Gly Ala Cys Ala Thr Gly Thr 
        915                 920                 925             


Gly Gly Ala Ala Gly Cys Ala Cys Thr Thr Thr Ala Ala Gly Thr Thr 
    930                 935                 940                 


Thr Thr Thr Thr Cys Ala Thr Cys Ala Thr Ala Ala Cys Ala Thr Ala 
945                 950                 955                 960 


Ala Ala Thr Thr Ala Thr Thr Thr Thr Cys Ala Ala Gly Thr Gly Thr 
                965                 970                 975     


Ala Ala Cys Thr Thr Ala Thr Thr Ala Ala Cys Cys Thr Ala Thr Thr 
            980                 985                 990         


Thr Ala Thr Thr Ala Thr Thr Thr  Ala Thr Gly Thr Ala  Thr Thr Thr 
        995                 1000                 1005             


Ala Thr  Thr Thr Ala Ala Gly  Cys Ala Thr Cys Ala  Ala Ala Thr 
    1010                 1015                 1020             


Ala Thr  Thr Thr Gly Thr Gly  Cys Ala Ala Gly Ala  Ala Thr Thr 
    1025                 1030                 1035             


Thr Gly  Gly Ala Ala Ala Ala  Ala Thr Ala Gly Ala  Ala Gly Ala 
    1040                 1045                 1050             


Thr Gly  Ala Ala Thr Cys Ala  Thr Thr Gly Ala Thr  Thr Gly Ala 
    1055                 1060                 1065             


Ala Thr  Ala Gly Thr Thr Ala  Thr Ala Ala Ala Gly  Ala Thr Gly 
    1070                 1075                 1080             


Thr Thr  Ala Thr Ala Gly Thr  Ala Ala Ala Thr Thr  Thr Ala Thr 
    1085                 1090                 1095             


Thr Thr  Thr Ala Thr Thr Thr  Thr Ala Gly Ala Thr  Ala Thr Thr 
    1100                 1105                 1110             


Ala Ala  Ala Thr Gly Ala Thr  Gly Thr Thr Thr Thr  Ala Thr Thr 
    1115                 1120                 1125             


Ala Gly  Ala Thr Ala Ala Ala  Thr Thr Thr Cys Ala  Ala Thr Cys 
    1130                 1135                 1140             


Ala Gly  Gly Gly Thr Thr Thr  Thr Thr Ala Gly Ala  Thr Thr Ala 
    1145                 1150                 1155             


Ala Ala  Cys Ala Ala Ala Cys  Ala Ala Ala Cys Ala  Ala Thr Thr 
    1160                 1165                 1170             


Gly Gly  Gly Thr Ala Cys Cys  Cys Ala Gly Thr Thr  Ala Ala Ala 
    1175                 1180                 1185             


Thr Thr  Thr Thr Cys Ala Thr  Thr Thr Cys Ala Gly  Ala Thr Ala 
    1190                 1195                 1200             


Ala Ala  Cys Ala Ala Cys Ala  Ala Ala Thr Ala Ala  Thr Thr Thr 
    1205                 1210                 1215             


Thr Thr  Thr Ala Gly Thr Ala  Thr Ala Ala Gly Thr  Ala Cys Ala 
    1220                 1225                 1230             


Thr Thr  Ala Thr Thr Gly Thr  Thr Thr Ala Thr Cys  Thr Gly Ala 
    1235                 1240                 1245             


Ala Ala  Thr Thr Thr Thr Ala  Ala Thr Thr Gly Ala  Ala Cys Thr 
    1250                 1255                 1260             


Ala Ala  Cys Ala Ala Thr Cys  Cys Thr Ala Gly Thr  Thr Thr Gly 
    1265                 1270                 1275             


Ala Thr  Ala Cys Thr Cys Cys  Cys Ala Gly Thr Cys  Thr Thr Gly 
    1280                 1285                 1290             


Thr Cys  Ala Thr Thr Gly Cys  Cys Ala Gly Cys Thr  Gly Thr Gly 
    1295                 1300                 1305             


Thr Thr  Gly Gly Thr Ala Gly  Thr Gly Cys Thr Gly  Thr Gly Thr 
    1310                 1315                 1320             


Thr Gly  Ala Ala Thr Thr Ala  Cys Gly Gly Ala Ala  Thr Ala Ala 
    1325                 1330                 1335             


Thr Gly  Ala Gly Thr Thr Ala  Gly Ala Ala Cys Thr  Ala Thr Thr 
    1340                 1345                 1350             


Ala Ala  Ala Ala Cys Ala Gly  Cys Cys Ala Ala Ala  Ala Cys Thr 
    1355                 1360                 1365             


Cys Cys  Ala Cys Ala Gly Thr  Cys Ala Ala Thr Ala  Thr Thr Ala 
    1370                 1375                 1380             


Gly Thr  Ala Ala Thr Thr Thr  Cys Thr Thr Gly Cys  Thr Gly Gly 
    1385                 1390                 1395             


Thr Thr  Gly Ala Ala Ala Cys  Thr Thr Gly Thr Thr  Thr Ala Thr 
    1400                 1405                 1410             


Thr Ala  Thr Gly Thr Ala Cys  Ala Ala Ala Thr Ala  Gly Ala Thr 
    1415                 1420                 1425             


Thr Cys  Thr Thr Ala Thr Ala  Ala Thr Ala Thr Thr  Ala Thr Thr 
    1430                 1435                 1440             


Thr Ala  Ala Ala Thr Gly Ala  Cys Thr Gly Cys Ala  Thr Thr Thr 
    1445                 1450                 1455             


Thr Thr  Ala Ala Ala Thr Ala  Cys Ala Ala Gly Gly  Cys Thr Thr 
    1460                 1465                 1470             


Thr Ala  Thr Ala Thr Thr Thr  Thr Thr Ala Ala Cys  Thr Thr Thr 
    1475                 1480                 1485             


Ala Ala  Gly Ala Thr Gly Thr  Thr Thr Thr Thr Ala  Thr Gly Thr 
    1490                 1495                 1500             


Gly Cys  Thr Cys Thr Cys Cys  Ala Ala Ala Thr Thr  Thr Thr Thr 
    1505                 1510                 1515             


Thr Thr  Thr Ala Cys Thr Gly  Thr Thr Thr Cys Thr  Gly Ala Thr 
    1520                 1525                 1530             


Thr Gly  Thr Ala Thr Gly Gly  Ala Ala Ala Thr Ala  Thr Ala Ala 
    1535                 1540                 1545             


Ala Ala  Gly Thr Ala Ala Ala  Thr Ala Thr Gly Ala  Ala Ala Cys 
    1550                 1555                 1560             


Ala Thr  Thr Thr Ala Ala Ala  Ala Thr Ala Thr Ala  Ala Thr Thr 
    1565                 1570                 1575             


Thr Gly  Thr Thr Gly Thr Cys  Ala Ala Ala Gly Thr  Ala Ala Ala 
    1580                 1585                 1590             


Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala Ala Ala  
    1595                 1600                 1605 


<210>  8
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210>  9
<211>  4753
<212>  DNA
<213>  Homo sapiens

<400>  9
ctttggaaag tcccgtggaa atccccgggc ctacaacccg catacaactg aaacggggca       60

aagcagactg cgcagtctgc agtcttcgtg gcgggccaag cgagcttgga gcccgcgggg      120

gcggagcggt gagagcggcc gccaagagag atcacacccc cagccgaccc tgccagcgag      180

cgagcccgac cccaggcgtc catggagcgt cgcctccgcc cggtccctgc cccgaccccc      240

gcctgcggcg cgctcctgcc ttgaccagga cttgggactt tgcgaaagga tcgcggggcc      300

cggagaggta accgccgcgc ctcccggaga ggtaaccgcc gcgcctcccg gagaggtgtt      360

ggagagcaca atggctgaac aagtccttcc tcaggctttg tatttgagca atatgcggaa      420

agctgtgaag atacgggaga gaactccaga agacattttt aaacctacta atgggatcat      480

tcatcatttt aaaaccatgc accgatacac actggaaatg ttcagaactt gccagttttg      540

tcctcagttt cgggagatca tccacaaagc cctcatcgac agaaacatcc aggccaccct      600

ggaaagccag aagaaactca actggtgtcg agaagtccgg aagcttgtgg cgctgaaaac      660

gaacggtgac ggcaattgcc tcatgcatgc cacttctcag tacatgtggg gcgttcagga      720

cacagacttg gtactgagga aggcgctgtt cagcacgctc aaggaaacag acacacgcaa      780

ctttaaattc cgctggcaac tggagtctct caaatctcag gaatttgttg aaacggggct      840

ttgctatgat actcggaact ggaatgatga atgggacaat cttatcaaaa tggcttccac      900

agacacaccc atggcccgaa gtggacttca gtacaactca ctggaagaaa tacacatatt      960

tgtcctttgc aacatcctca gaaggccaat cattgtcatt tcagacaaaa tgctaagaag     1020

tttggaatca ggttccaatt tcgccccttt gaaagtgggt ggaatttact tgcctctcca     1080

ctggcctgcc caggaatgct acagataccc cattgttctc ggctatgaca gccatcattt     1140

tgtacccttg gtgaccctga aggacagtgg gcctgaaatc cgagctgttc cacttgttaa     1200

cagagaccgg ggaagatttg aagacttaaa agttcacttt ttgacagatc ctgaaaatga     1260

gatgaaggag aagctcttaa aagagtactt aatggtgata gaaatccccg tccaaggctg     1320

ggaccatggc acaactcatc tcatcaatgc cgcaaagttg gatgaagcta acttaccaaa     1380

agaaatcaat ctggtagatg attactttga acttgttcag catgagtaca agaaatggca     1440

ggaaaacagc gagcagggga ggagagaggg gcacgcccag aatcccatgg aaccttccgt     1500

gccccagctt tctctcatgg atgtaaaatg tgaaacgccc aactgcccct tcttcatgtc     1560

tgtgaacacc cagcctttat gccatgagtg ctcagagagg cggcaaaaga atcaaaacaa     1620

actcccaaag ctgaactcca agccgggccc tgaggggctc cctggcatgg cgctcggggc     1680

ctctcgggga gaagcctatg agcccttggc gtggaaccct gaggagtcca ctggggggcc     1740

tcattcggcc ccaccgacag cacccagccc ttttctgttc agtgagacca ctgccatgaa     1800

gtgcaggagc cccggctgcc ccttcacact gaatgtgcag cacaacggat tttgtgaacg     1860

ttgccacaac gcccggcaac ttcacgccag ccacgcccca gaccacacaa ggcacttgga     1920

tcccgggaag tgccaagcct gcctccagga tgttaccagg acatttaatg ggatctgcag     1980

tacttgcttc aaaaggacta cagcagaggc ctcctccagc ctcagcacca gcctccctcc     2040

ttcctgtcac cagcgttcca agtcagatcc ctcgcggctc gtccggagcc cctccccgca     2100

ttcttgccac agagctggaa acgacgcccc tgctggctgc ctgtctcaag ctgcacggac     2160

tcctggggac aggacgggga cgagcaagtg cagaaaagcc ggctgcgtgt attttgggac     2220

tccagaaaac aagggctttt gcacactgtg tttcatcgag tacagagaaa acaaacattt     2280

tgctgctgcc tcagggaaag tcagtcccac agcgtccagg ttccagaaca ccattccgtg     2340

cctggggagg gaatgcggca cccttggaag caccatgttt gaaggatact gccagaagtg     2400

tttcattgaa gctcagaatc agagatttca tgaggccaaa aggacagaag agcaactgag     2460

atcgagccag cgcagagatg tgcctcgaac cacacaaagc acctcaaggc ccaagtgcgc     2520

ccgggcctcc tgcaagaaca tcctggcctg ccgcagcgag gagctctgca tggagtgtca     2580

gcatcccaac cagaggatgg gccctggggc ccaccggggt gagcctgccc ccgaagaccc     2640

ccccaagcag cgttgccggg cccccgcctg tgatcatttt ggcaatgcca agtgcaacgg     2700

ctactgcaac gaatgctttc agttcaagca gatgtatggc taaccggaaa caggtgggtc     2760

acctcctgca agaagtgggg cctcgagctg tcagtcatca tggtgctatc ctctgaaccc     2820

ctcagctgcc actgcaacag tgggcttaag ggtgtctgag caggagagga aagataagct     2880

cttcgtggtg cccacgatgc tcaggtttgg taacccggga gtgttcccag gtggccttag     2940

aaagcaaagc ttgtaactgg caagggatga tgtcagattc agcccaaggt tcctcctctc     3000

ctaccaagca ggaggccagg aacttctttg gacttggaag gtgtgcgggg actggccgag     3060

gcccctgcac cctgcgcatc aggactgctt catcgtcttg gctgagaaag ggaaaagaca     3120

cacaagtcgc gtgggttgga gaagccagag ccattccacc tcccctcccc cagcatctct     3180

cagagatgtg aagccagatc ctcatggcag cgaggccctc tgcaagaagc tcaaggaagc     3240

tcagggaaaa tggacgtatt cagagagtgt ttgtagttca tggtttttcc ctacctgccc     3300

ggttcctttc ctgaggaccc ggcagaaatg cagaaccatc catggactgt gattctgagg     3360

ctgctgagac tgaacatgtt cacattgaca gaaaaacaag ctgctcttta taatatgcac     3420

cttttaaaaa attagaatat tttactggga agacgtgtaa ctctttgggt tattactgtc     3480

tttacttcta aagaagttag cttgaactga ggagtaaaag tgtgtacata tataatatac     3540

ccttacatta tgtatgaggg atttttttaa attatattga aatgctgccc tagaagtaca     3600

ataggaaggc taaataataa taacctgttt tctggttgtt gttggggcat gagcttgtgt     3660

atacactgct tgcataaact caaccagctg cctttttaaa gggagctcta gtcctttttg     3720

tgtaattcac tttatttatt ttattacaaa cttcaagatt atttaagtga agatatttct     3780

tcagctctgg ggaaaatgcc acagtgttct cctgagagaa catccttgct ttgagtcagg     3840

ctgtgggcaa gttcctgacc acagggagta aattggcctc tttgatacac ttttgcttgc     3900

ctccccagga aagaaggaat tgcatccaag gtatacatac atattcatcg atgtttcgtg     3960

cttctcctta tgaaactcca gctatgtaat aaaaaactat actctgtgtt ctgttaatgc     4020

ctctgagtgt cctacctcct tggagatgag atagggaagg agcagggatg agactggcaa     4080

tggtcacagg gaaagatgtg gccttttgtg atggttttat tttctgttaa cactgtgtcc     4140

tgggggggct gggaagtccc ctgcatccca tggtaccctg gtattgggac agcaaaagcc     4200

agtaaccatg agtatgagga aatctctttc tgttgctggc ttacagtttc tctgtgtgct     4260

ttgtggttgc tgtcatattt gctctagaag aaaaaaaaaa aaggagggga aatgcatttt     4320

ccccagagat aaaggctgcc attttggggg tctgtactta tggcctgaaa atatttgtga     4380

tccataactc tacacagcct ttactcatac tattaggcac actttcccct tagagccccc     4440

taagtttttc ccagacgaat ctttataatt tctttccaaa gataccaaat aaacttcagt     4500

gttttcatct aattctctta aagttgatat cttaatattt tgtgttgatc attatttcca     4560

ttcttaatgt gaaaaaaagt aattatttat acttattata aaaagtattt gaaatttgca     4620

catttaattg tccctaatag aaagccacct attctttgtt ggatttcttc aagtttttct     4680

aaataaatgt aacttttcac aagagtcaac attaaaaaat aaattattta agaacagaaa     4740

aaaaaaaaaa aaa                                                        4753


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  10
tccctggaga agagctacga                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  11
agcactgtgt tggcgtacag                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  12
gaacgtcttg ctcgagatgt g                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  13
ccagcaggtc agcaaagaat t                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  14
aatcccatca ccatcttcca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  15
tggactccac gacgtactca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  16
ccttggaagc accatgtttg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  17
ttgtgtggtt cgaggcacat                                                   20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  18
gggaagagga gagagaaaga gc                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  19
tccaggattg gaattacaca ag                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  20
tcctgatttc tgcagctctg t                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  21
aatttctgtg ttggcgcagt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  22
tctgcttcca ggtgacagtg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  23
atcttgagct cggcagtgtt                                                   20


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  24
agcatccttg gggagagc                                                     18


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  25
aggcagtcac ctccacctc                                                    19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  26
gagaagccaa tggagattgc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  27
gacatcctga aggtgctgct                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  28
cctctggtga acctgcctac                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  29
taccctgcac cacagcaata                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  30
ggtattggtg agtcggatcg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  31
tgctgcattg ttcccataga                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  32
tcaagacctt cagctccaag                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  33
tgacgctgag cgtgaagaag                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  34
caacctctcg atcctgaagc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  35
atcacgcctt acccattgag                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  36
gaaaactttc gtcatactcc g                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  37
gaaagtttgt gccttatgga g                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  38
cacgagcaat gaagcaaatg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  39
gtgcactggt gctttccttt                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  40
ctataatttg cgccgctgac                                                   20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  41
tttccttggg tcattgactt t                                                 21


