                         SEQUENCE LISTING

<110>  S-Biomedic N.V.
 
<120>  COMPOSITIONS FOR TREATING OXIDATIVE STRESS-ASSOCIATED SKIN 
       DISEASES AND SKIN AGEING AND DIAGNOSIS OF OXIDATIVE 
       STRESS-ASSOCIATED SKIN DISEASES

<130>  SBIO-001-PCT

<150>  18206646.4
<151>  2018-11-16

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  161
<212>  PRT
<213>  Cutibacterium acnes

<400>  1

Met Phe Val Gln Ile Ala Ala Ser Leu Ala Ala Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Gly Ile Pro Gly Ala Ala Thr Pro Ile Asp Glu Ser Gln Leu Pro 
            20                  25                  30          


Val Gly Pro Gln Val Ser Val Thr Asp Ser Ala Gln His Thr Gly Pro 
        35                  40                  45              


Phe Ala Ala Ser Ser Pro Leu Thr Ile Thr Val Lys Pro Gly Ala Pro 
    50                  55                  60                  


Cys Val Arg Ala Asp Gly Tyr Gln Glu Ser Met Val Thr Arg Val Leu 
65                  70                  75                  80  


Asp Asp Lys Gly His Gln Val Trp Thr Gly Thr Phe Asp Glu Ser Lys 
                85                  90                  95      


Leu Ile Gly Gly Thr Gly Leu Gly Thr Ala Thr Phe His Val Gly Ser 
            100                 105                 110         


Pro Ala Ala Ala Phe Asn Phe His Gly Ser Glu Arg Thr Thr Tyr Arg 
        115                 120                 125             


Thr Leu Ser Tyr Cys Ala Tyr Pro His Tyr Val Asn Gly Thr Arg Glu 
    130                 135                 140                 


Arg Leu Ser Gln Val Ser Val Lys Thr Phe Met Val Asp Pro Ala Leu 
145                 150                 155                 160 


Asn 
    


<210>  2
<211>  161
<212>  PRT
<213>  Cutibacterium acnes

<400>  2

Met Phe Val Gln Ile Ala Ala Ser Leu Ala Ala Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Gly Ile Pro Gly Ala Ala Thr Pro Ile Asp Glu Ser Gln Leu Pro 
            20                  25                  30          


Val Gly Pro Gln Val Ser Val Thr Asp Ser Ala Gln His Thr Gly Pro 
        35                  40                  45              


Phe Ala Ala Ser Ser Pro Leu Thr Ile Thr Val Lys Pro Gly Ala Pro 
    50                  55                  60                  


Cys Val Arg Ala Asp Gly Tyr Gln Glu Ser Met Val Thr Arg Val Leu 
65                  70                  75                  80  


Asp Asp Lys Gly His Gln Val Trp Thr Gly Thr Phe Asp Glu Ser Lys 
                85                  90                  95      


Leu Ile Gly Gly Thr Gly Leu Gly Thr Ala Thr Phe His Val Gly Ser 
            100                 105                 110         


Pro Ala Ala Ala Phe Asn Phe His Gly Ser Glu Arg Thr Thr Tyr Arg 
        115                 120                 125             


Thr Leu Ser Tyr Cys Ala Tyr Pro His Tyr Val Asn Gly Thr Arg Glu 
    130                 135                 140                 


Arg Leu Ser Gln Val Ser Val Lys Thr Phe Met Val Asp Pro Thr Leu 
145                 150                 155                 160 


Asn 
    


<210>  3
<211>  161
<212>  PRT
<213>  Cutibacterium acnes

<400>  3

Met Phe Val Gln Ile Ala Ala Ser Leu Ala Ala Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Gly Met Pro Gly Ala Ala Thr Pro Ile Asp Glu Ser Gln Leu Pro 
            20                  25                  30          


Val Gly Pro Gln Val Ser Val Thr Asp Ser Ala Gln His Thr Gly Pro 
        35                  40                  45              


Phe Ala Ala Ser Ser Pro Leu Ala Ile Thr Val Lys Pro Gly Ala Pro 
    50                  55                  60                  


Cys Val Arg Ala Asp Gly Tyr Gln Glu Ser Met Val Thr Arg Val Leu 
65                  70                  75                  80  


Asp Asp Lys Gly His Gln Val Trp Thr Gly Thr Phe Asp Glu Ser Lys 
                85                  90                  95      


Leu Ile Gly Gly Thr Gly Leu Gly Thr Ala Thr Phe His Val Glu Ser 
            100                 105                 110         


Pro Ala Ala Ala Phe Asn Phe His Gly Asn Glu Arg Thr Thr Tyr Arg 
        115                 120                 125             


Thr Leu Ser Tyr Cys Ala Tyr Pro His Tyr Val Asn Gly Thr Arg Glu 
    130                 135                 140                 


Arg Leu Ser Gln Val Ser Val Lys Thr Phe Met Val Asp Pro Ala Leu 
145                 150                 155                 160 


Asn 
    


<210>  4
<211>  161
<212>  PRT
<213>  Cutibacterium acnes

<400>  4

Met Phe Val Gln Ile Ala Ala Ser Leu Ala Ala Ala Ser Thr Ile Ala 
1               5                   10                  15      


Leu Gly Val Pro Gly Ala Ala Thr Pro Leu Asn Gly Ser Gln Leu Pro 
            20                  25                  30          


Thr Gly Pro Gln Val Ser Val Thr Asp Pro Ala Gln His Thr Gly Pro 
        35                  40                  45              


Phe Ser Thr Ala Thr Pro Leu Thr Ile Lys Val Lys Pro Ser Ala Pro 
    50                  55                  60                  


Cys Val Arg Ala Asp Gly Arg Gln Gln Ser Leu Val Ala Arg Val Leu 
65                  70                  75                  80  


Asp Asp Lys Gly His Gln Val Trp Ser Gly Thr Phe Asp Glu Ser Gln 
                85                  90                  95      


Leu Ile Gly Gly Thr Gly Arg Gly Thr Ala Thr Phe His Val Gly Ser 
            100                 105                 110         


Ala Ala Ala Ala Phe Asn Phe His Gly Gly Lys Arg Thr Thr Tyr Arg 
        115                 120                 125             


Ala Leu Gly Tyr Cys Ala Tyr Pro His Tyr Val Asn Gly Thr Arg Glu 
    130                 135                 140                 


Arg Leu Ser Gln Val Ser Val Lys Thr Phe Thr Val Asp Pro Ala Ile 
145                 150                 155                 160 


Asn 
    


<210>  5
<211>  142
<212>  DNA
<213>  Cutibacterium acnes

<400>  5
aagccggaag gcagataaac ctctacccgg gacgccgtcg tctccaacac cttagtgaca       60

ctatgcagtg ctatgctcca aacgaaagtc taaatgattt tcgctaattt ccatacgtac      120

gacatatcgg gagaccatca tg                                               142


<210>  6
<211>  142
<212>  DNA
<213>  Cutibacterium acnes

<400>  6
aagccggaag gcagataaac ctctacccgg gacgccgtcg tctccaacac cttagtgaca       60

ctatgcagtg ctatgctcca aacgaaagtc taaatgattt tcgctaattt ccatacgtac      120

gacatatcgg gagaccatca tg                                               142


<210>  7
<211>  143
<212>  DNA
<213>  Cutibacterium acnes

<400>  7
aaaccgaaag gcaaacccac cccctaccgg gcctaccgtt gccgccggca cgtcgatgac       60

actatgcagt gctacgctct agcagaaaat tcatatgatt ttcgtcaatt cccatacgta      120

cgacatatca ggagatcgtc atg                                              143


<210>  8
<211>  143
<212>  DNA
<213>  Cutibacterium acnes

<400>  8
aaaccgaaag acagacccac cccctaccgg acataccgtt gccgccaaca cttcaatgac       60

actatgcagt gctacgctct agtcgagaat ctatatgatt ttcgtcaatt cccatacgta      120

cgacatatcg ggagatcgtc atg                                              143


<210>  9
<211>  143
<212>  DNA
<213>  Cutibacterium acnes

<400>  9
aaaccgaaag gcagacccac cccctaccgg gcataccgtt gccgccgaca cttcgatgac       60

actatgcagt gctatacttc agctgaaagt ctatatgatt ttcgtcaatt cccatacgta      120

cgacatatcg ggagatcgtc atg                                              143


<210>  10
<211>  143
<212>  DNA
<213>  Cutibacterium acnes

<400>  10
aaaccgaaag gcagacccac cccctaccgg gcataccgtt gccgccgaca cttcgatgac       60

actatgcagt gctatacttc agctgaaaat ctatatgatt ttcgtcaatt cccatacgta      120

cgacatatcg ggagatcgtc atg                                              143


<210>  11
<211>  143
<212>  DNA
<213>  Cutibacterium acnes

<400>  11
aaaccgaaag gcagacccac cccctaccgg gcataccgtt gccgccgaca cttcgatgac       60

actatgcagt gctacacttc aactgaaaat ctatatgatt ttcgtcaatt cccatacgta      120

cgacatatcg ggagatcgtc atg                                              143


<210>  12
<211>  143
<212>  DNA
<213>  Cutibacterium acnes

<400>  12
aaaccgaaag gcagacccac cccctaccgg gcataccgtt gccgccgaca cttcgatgac       60

actatgcagt gctacacttc aactgaaaat ctatatgatt ttcgtcaatt cccatacgta      120

cgacacatcg ggagatcgtc atg                                              143


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  13
gcatctagcc ctctcaccat                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  14
ctgagagtcc ggtaggtggt                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  15
gcatcatgac taccgtccac                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  16
cggtggtctc cttagaggtc                                                   20


<210>  17
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  17
ggctgaagct gaattcacac ccatcgatga gagccaac                               38


<210>  18
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  18
gatgatgatg gtcgactcct gctgcgccgt tgagggcggg atccacc                     47


<210>  19
<211>  161
<212>  PRT
<213>  Cutibacterium acnes

<400>  19

Met Phe Val Gln Ile Ala Ala Ser Leu Ala Ala Ala Ser Thr Ile Ala 
1               5                   10                  15      


Leu Gly Val Pro Gly Ala Ala Thr Pro Leu Asn Gly Ser Gln Leu Pro 
            20                  25                  30          


Thr Gly Pro Gln Val Ser Val Thr Asp Pro Ala Gln His Thr Gly Pro 
        35                  40                  45              


Phe Ser Thr Ala Thr Pro Leu Thr Ile Lys Val Lys Pro Ser Ala Pro 
    50                  55                  60                  


Cys Val Arg Ala Asp Gly Arg Gln Gln Ser Leu Val Ala Arg Val Leu 
65                  70                  75                  80  


Asp Asp Lys Gly His Gln Val Trp Ser Gly Thr Phe Asp Glu Ser Gln 
                85                  90                  95      


Leu Ile Gly Gly Thr Gly Arg Gly Thr Ala Thr Phe His Val Gly Ser 
            100                 105                 110         


Ala Ala Ala Ala Phe Asn Phe His Gly Gly Lys Arg Thr Thr Tyr Arg 
        115                 120                 125             


Ala Leu Gly Tyr Cys Ala Tyr Pro His Tyr Val Asn Gly Thr Arg Glu 
    130                 135                 140                 


Arg Leu Ser Gln Val Ser Val Lys Thr Phe Thr Val Asp Pro Ala Ile 
145                 150                 155                 160 


Asn 
    


<210>  20
<211>  18
<212>  PRT
<213>  Cutibacterium acnes

<400>  20

Val Arg Ala Asp Gly Tyr Gln Glu Ser Met Val Thr Arg Val Leu Asp 
1               5                   10                  15      


Asp Lys 
        


<210>  21
<211>  13
<212>  PRT
<213>  Cutibacterium acnes

<400>  21

Arg Thr Leu Ser Tyr Cys Ala Tyr Pro His Tyr Val Asn 
1               5                   10              


