                         SEQUENCE LISTING

<110>  UROVANT SCIENCES GMBH
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF SMOOTH MUSCLE 
       DYSFUNCTION

<130>  3987.026PC02

<150>  US62/767,457
<151>  2018-11-14
<150>  US62/873,064
<151>  2019-07-11

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human cytomegalovirus

<400>  1
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 priming site

<400>  2
taatacgact cactataggg                                                   20


<210>  3
<211>  239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGH polyA

<400>  3
agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc       60

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc      120

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg      180

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta gtgggctct       239


<210>  4
<211>  679
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC origin of replication

<400>  4
ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct       60

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa      120

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag      180

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc      240

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg      300

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca      360

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat      420

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg      480

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc      540

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc      600

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctgggc ttttgctggc      660

cttttgctca catgttctt                                                   679


<210>  5
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kanamycin resistance marker

<400>  5
ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc       60

tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc      120

tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg      180

aactgcaaga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag      240

ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg      300

ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg      360

caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac      420

atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg      480

acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgagcatgc      540

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg      600

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc      660

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc      720

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc      780

ttcttgacga gttcttctga                                                  800


<210>  6
<211>  3779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild type human Maxi-K alpha subunit (Slo)

<400>  6
atggcaaacg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggcgga       60

ggcagcggtc ttagaatgag cagcaatatc cacgcgaacc atctcagcct agacgcgtcc      120

tcctcctcct cctcctcctc ttcctcttct tcttcttcct cctcctcttc ctcctcgtcc      180

tcggtccacg agcccaagat ggatgcgctc atcatcccgg tgaccatgga ggtgccgtgc      240

gacagccggg gccaacgcat gtggtgggct ttcctggcct cctccatggt gactttcttc      300

gggggcctct tcatcatctt gctctggcgg acgctcaagt acctgtggac cgtgtgctgc      360

cactgcgggg gcaagacgaa ggaggcccag aagattaaca atggctcaag ccaggcggat      420

ggcactctca aaccagtgga tgaaaaagag gaggcagtgg ccgccgaggt cggctggatg      480

acctccgtga aggactgggc gggggtgatg atatccgccc agacactgac tggcagagtc      540

ctggttgtct tagtctttgc tctcagcatc ggtgcacttg taatatactt catagattca      600

tcaaacccaa tagaatcctg ccagaatttc tacaaagatt tcacattaca gatcgacatg      660

gctttcaacg tgttcttcct tctctacttt ggcttgcggt ttattgcagc caacgataaa      720

ttgtggttct ggctggaagt gaactctgta gtggatttct tcacggtgcc ccccgtgttt      780

gtgtctgtgt acttaaacag aagttggctt ggtttgagat ttttaagagc tctgagactg      840

atacagtttt cagaaatttt gcagtttctg aatattctta aaacaagtaa ttccatcaag      900

ctggtgaatc tgctctccat atttatcagc acgtggctga ctgcagctgg gttcatccat      960

ttggtggaga attcagggga cccatgggaa aatttccaaa acaaccaggc tctcacctac     1020

tgggaatgtg tcatttactc atggtcacaa tgtccaccgt tggttatggg gatgtttatg     1080

caaaaaccac acttcggcgc ctcttcatgg tcttcttcat cctcggggga ctggccatgt     1140

ttgccagcta cgtccctgaa atcatagagt taataggaaa ccgcaagaaa tacgggggct     1200

cctatagtgc ggttagtgga agaaagcaca ttgtggtctg cggacacatc actctggaga     1260

gtgtttccaa cttcctgaag gactttctgc acaaggaccg ggatgacgtc aatgtggaga     1320

tcgtttttct tcacaacatc tcccccaacc tggagcttga agctctgttc aaacgacatt     1380

ttactcaggt ggaattttat cagggttccg tcctcaatcc acatgatctt gcaagagtca     1440

agatagagtc agcagatgca tgcctgatcc ttgccaacaa gtactgcgct gacccggatg     1500

cggaggatgc ctcgaatatc atgagagtaa tctccataaa gaactaccat ccgaagataa     1560

gaatcatcac tcaaatgctg cagtatcaca acaaggccca tctgctaaac atccgagctg     1620

gaattggaaa gaaggtgatg acgcaatctg cctcgcagag ttgaagttgg gcttcatagc     1680

ccagagctgc ctggctcaag gcctctccac catgcttgcc aaccttctcc atgaggtcat     1740

tcataaagat tgaggaagac acatggcaga aatactactt ggaaggagtc tcaaatcaaa     1800

tgtacacaga atatctctcc agtgccttcg tgggtctgtc cttccctact gtttgtgagc     1860

tgtgttttgt gaagctcaag ctcctaatga tagccattga gtacaagtct gccaaccgag     1920

agagccgtat attaattaat cctggaaacc attttaagat ccaagaaggt actttaggat     1980

ttttcatcgc aagtgatgcc aaagaagtta aaagggcatt tttttactgc aaggcctgtc     2040

atgatgacat cacagatccc aaaagaataa aaaaatgtgg ctgcaaacgg cttgaagatg     2100

agcagccgtc aacactatca ccaaaaaaaa agcaacggaa tggaggcatg cggaactcac     2160

ccaacacctc gcctaagctg atgaggcatg accccttgtt aattcctggc aatgatcaga     2220

ttgacaacat ggactccaat gtgaagaagt acgactctac tgggatgttt cactggtgtg     2280

cacccaagga gatagagaaa gtcatcctga ctcgaagtga agctgccatg accgtcctga     2340

gtggccatgt cgtggtctgc atctttggcg acgtcagctc agccctgatc ggcctccgga     2400

acctggtgat gccgctccgt gccagcaact ttcattacca tgagctcaag cacattgtgt     2460

ttgtgggctc tattgagtac ctcaagcggg aatgggagac gcttcataac ttccccaaag     2520

tgtccatatt gcctggtacg ccattaagtc gggctgattt aagggctgtc aacatcaacc     2580

tctgtgacat gtgcgttatc ctgtcagcca atcagaataa tattgatgat acttcgctgc     2640

aggacaagga atgcatcttg gcgtcactca acatcaaatc tatgcagttt gatgacagca     2700

tcggagtctt gcaggctaat tcccaagggt tcacacctcc aggaatggat agatcctctc     2760

cagataacag cccagtgcac gggatgttac gtcaaccatc catcacaact ggggtcaaca     2820

tccccatcat cactgaacta gtgaacgata ctaatgttca gtttttggac caagacgatg     2880

atgatgaccc tgatacagaa ctgtacctca cgcagccctt tgcctgtggg acagcatttg     2940

ccgtcagtgt cctggactca ctcatgagcg cgacgtactt caatgacaat atcctcaccc     3000

tgatacggac cctggtgacc ggaggagcca cgccggagct ggaggctctg attgctgagg     3060

aaaacgccct tagaggtggc tacagcaccc cgcagacact ggccaatagg gaccgctgcc     3120

gcgtggccca gttagctctg ctcgatgggc catttgcgga cttaggggat ggtggttgtt     3180

atggtgatct gttctgcaaa gctctgaaaa catataatat gctttgtttt ggaatttacc     3240

ggctgagaga tgctcacctc agcaccccca gtcagtgcac aaagaggtat gtcatcacca     3300

acccgcccta tgagtttgag ctcgtgccga cggacctgat cttctgctta atgcagtttg     3360

accacaatgc cggccagtcc cgggccagcc tgtcccattc ctcccactcg tcgcagtcct     3420

ccagcaagaa gagctcctct gttcactcca tcccatccac agcaaaccga cagaaccggc     3480

ccaagtccag ggagtcccgg gacaaacaga agtacgtgca ggaagagcgg ctttgatatg     3540

tgtatccacc gccactgtgt gaaactgtat ctgccactca tttccccagt tggtgtttcc     3600

aacaaagtaa ctttccctgt tttcccctgt agtccccccc ttttttttta cacatatttg     3660

catatgtatg atagtgtgca tgtggttgtc atttttattt caccaccata aaacccttga     3720

gcacaacagc aaataagcag acgggctccg gaattcctgc agcccggggg atccactag      3779


<210>  7
<211>  3533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hSlo ORF, NA; wild type human Maxi-K alpha subunit (Slo)

<400>  7
atggcaaatg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggaggc       60

agcagtctta gaatgagtag caatatccac gcgaaccatc tcagcctaga cgtgtcctcc      120

tcctcctcct cctcctcttc ctcttcttct tcttcctcct cctcttcctc ctcgtcctcg      180

gtccacgagc ccaagatgga tgcgctcatc atcccggtga ccatggaggt gccgtgcgac      240

agccggggcc aacgcatgtg gtgggctttc ctggcctcct ccatggtgac tttcttcggg      300

ggcctcttca tcatcttgct ctggcggacg ctcaagtacc tgtggaccgt gtgctgccac      360

tgcgggggca agacgaagga ggcccagaag attaacaatg gctcaagcca ggcggatggc      420

actctcaaac cagtggatga aaaagaggag gcagtggccg ccgaggtcgg ctggatgacc      480

tccgtgaagg actgggcggg ggtgatgata tccgcccaga cactgactgg cagagtcctg      540

gttgtcttag tctttgctct cagcatcggt gcacttgtaa tatacttcat agattcatca      600

aacccaatag aatcctgcca gaatttctac aaagatttca cattacagat cgacatggct      660

ttcaacgtgt tcttccttct ctacttcggc ttgcggttta ttgcagccaa cgataaattg      720

tggttctggc tggaagtgaa ctctgtagtg gatttcttca cggtgccccc cgtgtttgtg      780

tctgtgtact taaacagaag ttggcttggt ttgagatttt taagagctct gagactgata      840

cagttttcag aaattttgca gtttctgaat attcttaaaa caagtaattc catcaagctg      900

gtgaatctgc tctccatatt tatcagcacg tggctgactg cagccgggtt catccatttg      960

gtggagaatt caggggaccc atgggaaaat ttccaaaaca accaggctct cacctactgg     1020

gaatgtgtct atttactcat ggtcacaatg tccaccgttg gttatgggga tgtttatgca     1080

aaaaccacac ttgggcgcct cttcatggtc ttcttcatcc tcgggggact ggccatgttt     1140

gccagctacg tccctgaaat catagagtta ataggaaacc gcaagaaata cgggggctcc     1200

tatagtgcgg ttagtggaag aaagcacatt gtggtctgcg gacacatcac tctggagagt     1260

gtttccaact tcctgaagga ctttctgcac aaggaccggg atgacgtcaa tgtggagatc     1320

gtttttcttc acaacatctc ccccaacctg gagcttgaag ctctgttcaa acgacatttt     1380

actcaggtgg aattttatca gggttccgtc ctcaatccac atgatcttgc aagagtcaag     1440

atagagtcag cagatgcatg cctgatcctt gccaacaagt actgcgctga cccggatgcg     1500

gaggatgcct cgaatatcat gagagtaatc tccataaaga actaccatcc gaagataaga     1560

atcatcactc aaatgctgca gtatcacaac aaggcccatc tgctaaacat cccgagctgg     1620

aattggaaag aaggtgatga cgcaatctgc ctcgcagagt tgaagttggg cttcatagcc     1680

cagagctgcc tggctcaagg cctctccacc atgcttgcca acctcttctc catgaggtca     1740

ttcataaaga ttgaggaaga cacatggcag aaatactact tggaaggagt ctcaaatgaa     1800

atgtacacag aatatctctc cagtgccttc gtgggtctgt ccttccctac tgtttgtgag     1860

ctgtgttttg tgaagctcaa gctcctaatg atagccattg agtacaagtc tgccaaccga     1920

gagagccgta tattaattaa tcctggaaac catcttaaga tccaagaagg tactttagga     1980

tttttcatcg caagtgatgc caaagaagtt aaaagggcat ttttttactg caaggcctgt     2040

catgatgaca tcacagatcc caaaagaata aaaaaatgtg gctgcaaacg gcttgaagag     2100

agcagccgtc aacactatca ccaaaaaaaa agcaacggaa tggaggcatg cggaactcac     2160

ccaacacctc gcctaagctg atgaggcatg accccttgtt aattcctggc aatgatcaga     2220

ttgacaacat ggactccaat gtgaagaagt acgactctac tgggatgttt cactggtgtg     2280

cacccaagga gatagagaaa gtcatcctga ctcgaagtga agctgccatg accgtcctga     2340

gtggccatgt cgtggtctgc atctttggcg acgtcagctc agccctgatc ggcctccgga     2400

acctggtgat gccgctccgt gccagcaact ttcattacca tgagctcaag cacattgtgt     2460

ttgtgggctc tattgagtac ctcaagcggg aatgggagac gcttcataac ttccccaaag     2520

tgtccatatt gcctggtacg ccattaagtc gggctgattt aagggctgtc aacatcaacc     2580

tctgtgacat gtgcgttatc ctgtcagcca atcagaataa tattgatgat acttcgctgc     2640

aggacaagga atgcatcttg gcgtcactca acatcaaatc tatgcagttt gatgacagca     2700

tcggagtctt gcaggctaat tcccaagggt tcacacctcc aggaatggat agatcctctc     2760

cagataacag cccagtgcac gggatgttac gtcaaccatc catcacaact ggggtcaaca     2820

tccccatcat cactgaacta gtgaacgata ctaatgttca gtttttggac caagacgatg     2880

atgatgaccc tgatacagaa ctgtacctca cgcagccctt tgcctgtggg acagcatttg     2940

ccgtcagtgt cctggactca ctcatgagcg cgacgtactt caatgacaat atcctcaccc     3000

tgatacggac cctggtgacc ggaggagcca cgccggagct ggaggctctg attgctgagg     3060

aaaacgccct tagaggtggc tacagcaccc cgcagacact ggccaatagg gaccgctgcc     3120

gcgtggccca gttagctctg ctcgatgggc catttgcgga cttaggggat ggtggttgtt     3180

atggtgatct gttctgcaaa gctctgaaaa catataatat gctttgtttt ggaatttacc     3240

ggctgagaga tgctcacctc agcaccccca gtcagtgcac aaagaggtat gtcatcacca     3300

acccgcccta tgagtttgag ctcgtgccga cggacctgat cttctgctta atgcagtttg     3360

accacaatgc cggccagtcc cgggccagcc tgtcccattc ctcccactcg tcgcagtcct     3420

ccagcaagaa gagctcctct gttcactcca tcccatccac agcaaaccga cagaaccggc     3480

ccaagtccag ggagtcccgg gacaaacaga agtacgtgca ggaagagcgg ctt            3533


<210>  8
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hSlo T352S mutant

<400>  8

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Val Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser 
    690                 695                 700                 


Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser 
705                 710                 715                 720 


Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro 
                725                 730                 735     


Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp 
            740                 745                 750         


Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val 
        755                 760                 765             


Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val 
    770                 775                 780                 


Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg 
785                 790                 795                 800 


Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu 
                805                 810                 815     


Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp 
            820                 825                 830         


Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro 
        835                 840                 845             


Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met 
    850                 855                 860                 


Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu 
865                 870                 875                 880 


Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln 
                885                 890                 895     


Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr 
            900                 905                 910         


Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly 
        915                 920                 925             


Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile Ile 
    930                 935                 940                 


Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp 
945                 950                 955                 960 


Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala Cys 
                965                 970                 975     


Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala Thr 
            980                 985                 990         


Tyr Phe Asn Asp Asn Ile Leu Thr  Leu Ile Arg Thr Leu  Val Thr Gly 
        995                 1000                 1005             


Gly Ala  Thr Pro Glu Leu Glu  Ala Leu Ile Ala Glu  Glu Asn Ala 
    1010                 1015                 1020             


Leu Arg  Gly Gly Tyr Ser Thr  Pro Gln Thr Leu Ala  Asn Arg Asp 
    1025                 1030                 1035             


Arg Cys  Arg Val Ala Gln Leu  Ala Leu Leu Asp Gly  Pro Phe Ala 
    1040                 1045                 1050             


Asp Leu  Gly Asp Gly Gly Cys  Tyr Gly Asp Leu Phe  Cys Lys Ala 
    1055                 1060                 1065             


Leu Lys  Thr Tyr Asn Met Leu  Cys Phe Gly Ile Tyr  Arg Leu Arg 
    1070                 1075                 1080             


Asp Ala  His Leu Ser Thr Pro  Ser Gln Cys Thr Lys  Arg Tyr Val 
    1085                 1090                 1095             


Ile Thr  Asn Pro Pro Tyr Glu  Phe Glu Leu Val Pro  Thr Asp Leu 
    1100                 1105                 1110             


Ile Phe  Cys Leu Met Gln Phe  Asp His Asn Ala Gly  Gln Ser Arg 
    1115                 1120                 1125             


Ala Ser  Leu Ser His Ser Ser  His Ser Ser Gln Ser  Ser Ser Lys 
    1130                 1135                 1140             


Lys Ser  Ser Ser Val His Ser  Ile Pro Ser Thr Ala  Asn Arg Gln 
    1145                 1150                 1155             


Asn Arg  Pro Lys Ser Arg Glu  Ser Arg Asp Lys Gln  Lys Tyr Val 
    1160                 1165                 1170             


Gln Glu  Glu Arg Leu 
    1175             


<210>  9
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SM22alpha promoter sequence

<400>  9
gaattcagga cgtaatcagt ggctggaaag caagagctct agaggagctc tgacccttcc       60

ttcagatgcc acaaggaggt gctggagttc tatgcaccaa cagccaggct ggctgtagtg      120

gattgagcgt ctgaggctgc acctctctgg gttctgggtg agactgaccc tgcctgaggg      180

ttctctcctt ccctctctct ccctctccct ctccctctct ctgtttcctg aggtttccag      240

gattggggat gacaccacta aagccttacc ttttaagaag ttgcattcag tgagtgtgtg      300

cagatagggg cagaggagag ctggttctgt ctccactgtg tttggtcttg tcagaccatc      360

aggtgtgata gcagttgtct ttaaccctaa ccctgagcct tcccttccca agaccactga      420

agctaggtgc aagataagtg gggacccttt aggatctttc acgataagga ctattttgaa      480

gggagggagg gtgacactgt ttaccctagt gtctccagcc ttgccaggcc ttaaacatcc      540

gcccattgtc aaggggccag ggttgacttg ctgctaaaca aggcactccc tagagaagca      600

gcataccata cctgtgggca ggatgaccca tgttctgcca cgcacttggt aggccacttt      660

gaacctcaat tttctcaact gttaaatggg gtggtaactg ataaagggga acgtgaaagg      720

aaggcgtttg catagtgcct ggttgtgcag gtcaagacta gttcccacca actcgatttt      780

aaagccttgc aagaaggtgg ccttgcaggt tcctttgtcg ggccaaactc tagaatgcct      840

ccccctttct agagcagacc caagtccggg taacaaggaa gggtttcagg gtcctgccca      900

ttcccggccg ccctcagcac cgccccgccc cgacccccgc agcatctcca cagcttatta      960

tagcttaaac cctgcagcca actcctttct gggactcaga agacatagca ggtactgaac     1020

gtctcacctg ctgaggtggt cctagtcctc acccgctcta gcccgctaga agccttggaa     1080

ctatctcata ccaggctgca cttgtttgtc ttctcattga taaaaggttt aagcatgcag     1140

agaatgtctc cggctgcccc cgacagactg ctccaacttg gtgtctttcc ccaaatatgg     1200

agcctgtgtg gagtgagtgg ggcggcccgg ggtggtgagc caagcagact tccatgggca     1260

gggaggggcg ccagcggacg gcagaggggt gacatcactg cctaggcggc ctttaaaccc     1320

ctcacccagc cggcgcccca gcccgtctgc cccagcccag acaccgaagc tactctcctt     1380

ccagtccaca aacgaccaag ccttgtaagt gcaagtcat                            1419


<210>  10
<211>  2999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVAX vector

<400>  10
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta      840

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca      900

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc      960

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     1020

gcaggcatgc tggggatgcg gtgggctcta tggcttctac tgggcggttt tatggacagc     1080

aagcgaaccg gaattgccag ctggggcgcc ctctggtaag gttgggaagc cctgcaaagt     1140

aaactggatg gctttctcgc cgccaaggat ctgatggcgc aggggatcaa gctctgatca     1200

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc     1260

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc     1320

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga     1380

cctgtccggt gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac     1440

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct     1500

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa     1560

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc     1620

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct     1680

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc     1740

caggctcaag gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg     1800

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct     1860

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct     1920

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca     1980

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga attattaacg cttacaattt     2040

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacaggtggc     2100

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     2160

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa     2220

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     2280

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     2340

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     2400

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     2460

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     2520

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     2580

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     2640

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     2700

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     2760

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     2820

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     2880

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     2940

agcaacgcgg cctttttacg gttcctgggc ttttgctggc cttttgctca catgttctt      2999


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated Slo subsequence

<400>  11
atggtcacaa tgtcctccgt tggttatggg gat                                    33


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to generate mutant

<400>  12
atggtcacaa tgtcctccgt tggttatggg gat                                    33


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to generate mutant

<400>  13
atccccataa ccaacggagg acattgtgac cat                                    33


<210>  14
<211>  3534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild type SLO, NA

<400>  14
atggcaaatg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggaggc       60

agcagtctta gaatgagtag caatatccac gcgaaccatc tcagcctaga cgtgtcctcc      120

tcctcctcct cctcctcttc ctcttcttct tcttcctcct cctcttcctc ctcgtcctcg      180

gtccacgagc ccaagatgga tgcgctcatc atcccggtga ccatggaggt gccgtgcgac      240

agccggggcc aacgcatgtg gtgggctttc ctggcctcct ccatggtgac tttcttcggg      300

ggcctcttca tcatcttgct ctggcggacg ctcaagtacc tgtggaccgt gtgctgccac      360

tgcgggggca agacgaagga ggcccagaag attaacaatg gctcaagcca ggcggatggc      420

actctcaaac cagtggatga aaaagaggag gcagtggccg ccgaggtcgg ctggatgacc      480

tccgtgaagg actgggcggg ggtgatgata tccgcccaga cactgactgg cagagtcctg      540

gttgtcttag tctttgctct cagcatcggt gcacttgtaa tatacttcat agattcatca      600

aacccaatag aatcctgcca gaatttctac aaagatttca cattacagat cgacatggct      660

ttcaacgtgt tcttccttct ctacttcggc ttgcggttta ttgcagccaa cgataaattg      720

tggttctggc tggaagtgaa ctctgtagtg gatttcttca cggtgccccc cgtgtttgtg      780

tctgtgtact taaacagaag ttggcttggt ttgagatttt taagagctct gagactgata      840

cagttttcag aaattttgca gtttctgaat attcttaaaa caagtaattc catcaagctg      900

gtgaatctgc tctccatatt tatcagcacg tggctgactg cagccgggtt catccatttg      960

gtggagaatt caggggaccc atgggaaaat ttccaaaaca accaggctct cacctactgg     1020

gaatgtgtct atttactcat ggtcacaatg tccaccgttg gttatgggga tgtttatgca     1080

aaaaccacac ttgggcgcct cttcatggtc ttcttcatcc tcgggggact ggccatgttt     1140

gccagctacg tccctgaaat catagagtta ataggaaacc gcaagaaata cgggggctcc     1200

tatagtgcgg ttagtggaag aaagcacatt gtggtctgcg gacacatcac tctggagagt     1260

gtttccaact tcctgaagga ctttctgcac aaggaccggg atgacgtcaa tgtggagatc     1320

gtttttcttc acaacatctc ccccaacctg gagcttgaag ctctgttcaa acgacatttt     1380

actcaggtgg aattttatca gggttccgtc ctcaatccac atgatcttgc aagagtcaag     1440

atagagtcag cagatgcatg cctgatcctt gccaacaagt actgcgctga cccggatgcg     1500

gaggatgcct cgaatatcat gagagtaatc tccataaaga actaccatcc gaagataaga     1560

atcatcactc aaatgctgca gtatcacaac aaggcccatc tgctaaacat cccgagctgg     1620

aattggaaag aaggtgatga cgcaatctgc ctcgcagagt tgaagttggg cttcatagcc     1680

cagagctgcc tggctcaagg cctctccacc atgcttgcca acctcttctc catgaggtca     1740

ttcataaaga ttgaggaaga cacatggcag aaatactact tggaaggagt ctcaaatgaa     1800

atgtacacag aatatctctc cagtgccttc gtgggtctgt ccttccctac tgtttgtgag     1860

ctgtgttttg tgaagctcaa gctcctaatg atagccattg agtacaagtc tgccaaccga     1920

gagagccgta tattaattaa tcctggaaac catcttaaga tccaagaagg tactttagga     1980

tttttcatcg caagtgatgc caaagaagtt aaaagggcat ttttttactg caaggcctgt     2040

catgatgaca tcacagatcc caaaagaata aaaaaatgtg gctgcaaacg gcttgaagat     2100

gagcagccgt caacactatc accaaaaaaa aagcaacgga atggaggcat gcggaactca     2160

cccaacacct cgcctaagct gatgaggcat gaccccttgt taattcctgg caatgatcag     2220

attgacaaca tggactccaa tgtgaagaag tacgactcta ctgggatgtt tcactggtgt     2280

gcacccaagg agatagagaa agtcatcctg actcgaagtg aagctgccat gaccgtcctg     2340

agtggccatg tcgtggtctg catctttggc gacgtcagct cagccctgat cggcctccgg     2400

aacctggtga tgccgctccg tgccagcaac tttcattacc atgagctcaa gcacattgtg     2460

tttgtgggct ctattgagta cctcaagcgg gaatgggaga cgcttcataa cttccccaaa     2520

gtgtccatat tgcctggtac gccattaagt cgggctgatt taagggctgt caacatcaac     2580

ctctgtgaca tgtgcgttat cctgtcagcc aatcagaata atattgatga tacttcgctg     2640

caggacaagg aatgcatctt ggcgtcactc aacatcaaat ctatgcagtt tgatgacagc     2700

atcggagtct tgcaggctaa ttcccaaggg ttcacacctc caggaatgga tagatcctct     2760

ccagataaca gcccagtgca cgggatgtta cgtcaaccat ccatcacaac tggggtcaac     2820

atccccatca tcactgaact agtgaacgat actaatgttc agtttttgga ccaagacgat     2880

gatgatgacc ctgatacaga actgtacctc acgcagccct ttgcctgtgg gacagcattt     2940

gccgtcagtg tcctggactc actcatgagc gcgacgtact tcaatgacaa tatcctcacc     3000

ctgatacgga ccctggtgac cggaggagcc acgccggagc tggaggctct gattgctgag     3060

gaaaacgccc ttagaggtgg ctacagcacc ccgcagacac tggccaatag ggaccgctgc     3120

cgcgtggccc agttagctct gctcgatggg ccatttgcgg acttagggga tggtggttgt     3180

tatggtgatc tgttctgcaa agctctgaaa acatataata tgctttgttt tggaatttac     3240

cggctgagag atgctcacct cagcaccccc agtcagtgca caaagaggta tgtcatcacc     3300

aacccgccct atgagtttga gctcgtgccg acggacctga tcttctgctt aatgcagttt     3360

gaccacaatg ccggccagtc ccgggccagc ctgtcccatt cctcccactc gtcgcagtcc     3420

tccagcaaga agagctcctc tgttcactcc atcccatcca cagcaaaccg acagaaccgg     3480

cccaagtcca gggagtcccg ggacaaacag aagtacgtgc aggaagagcg gctt           3534


<210>  15
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild type SLO, Protein

<400>  15

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Val Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser 
    690                 695                 700                 


Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser 
705                 710                 715                 720 


Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro 
                725                 730                 735     


Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp 
            740                 745                 750         


Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val 
        755                 760                 765             


Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val 
    770                 775                 780                 


Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg 
785                 790                 795                 800 


Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu 
                805                 810                 815     


Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp 
            820                 825                 830         


Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro 
        835                 840                 845             


Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met 
    850                 855                 860                 


Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu 
865                 870                 875                 880 


Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln 
                885                 890                 895     


Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr 
            900                 905                 910         


Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly 
        915                 920                 925             


Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile Ile 
    930                 935                 940                 


Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp 
945                 950                 955                 960 


Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala Cys 
                965                 970                 975     


Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala Thr 
            980                 985                 990         


Tyr Phe Asn Asp Asn Ile Leu Thr  Leu Ile Arg Thr Leu  Val Thr Gly 
        995                 1000                 1005             


Gly Ala  Thr Pro Glu Leu Glu  Ala Leu Ile Ala Glu  Glu Asn Ala 
    1010                 1015                 1020             


Leu Arg  Gly Gly Tyr Ser Thr  Pro Gln Thr Leu Ala  Asn Arg Asp 
    1025                 1030                 1035             


Arg Cys  Arg Val Ala Gln Leu  Ala Leu Leu Asp Gly  Pro Phe Ala 
    1040                 1045                 1050             


Asp Leu  Gly Asp Gly Gly Cys  Tyr Gly Asp Leu Phe  Cys Lys Ala 
    1055                 1060                 1065             


Leu Lys  Thr Tyr Asn Met Leu  Cys Phe Gly Ile Tyr  Arg Leu Arg 
    1070                 1075                 1080             


Asp Ala  His Leu Ser Thr Pro  Ser Gln Cys Thr Lys  Arg Tyr Val 
    1085                 1090                 1095             


Ile Thr  Asn Pro Pro Tyr Glu  Phe Glu Leu Val Pro  Thr Asp Leu 
    1100                 1105                 1110             


Ile Phe  Cys Leu Met Gln Phe  Asp His Asn Ala Gly  Gln Ser Arg 
    1115                 1120                 1125             


Ala Ser  Leu Ser His Ser Ser  His Ser Ser Gln Ser  Ser Ser Lys 
    1130                 1135                 1140             


Lys Ser  Ser Ser Val His Ser  Ile Pro Ser Thr Ala  Asn Arg Gln 
    1145                 1150                 1155             


Asn Arg  Pro Lys Ser Arg Glu  Ser Arg Asp Lys Gln  Lys Tyr Val 
    1160                 1165                 1170             


Gln Glu  Glu Arg Leu 
    1175             


<210>  16
<211>  6880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVAX/hSlo1 WT

<400>  16
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gcttcttgtt ctttttgcag aagctcagaa taaacgctca actttggcag      840

aatcgataag cttgatcgag cccctgcgcc tgccgcccat tgctagctat ggcaaacggt      900

ggcggcggcg gcggcggcag cagcggcggc ggcggcggcg gcggcggagg cagcggtctt      960

agaatgagca gcaatatcca cgcgaaccat ctcagcctag acgcgtcctc ctcctcctcc     1020

tcctcctctt cctcttcttc ttcttcctcc tcctcttcct cctcgtcctc ggtccacgag     1080

cccaagatgg atgcgctcat catcccggtg accatggagg tgccgtgcga cagccggggc     1140

caacgcatgt ggtgggcttt cctggcctcc tccatggtga ctttcttcgg gggcctcttc     1200

atcatcttgc tctggcggac gctcaagtac ctgtggaccg tgtgctgcca ctgcgggggc     1260

aagacgaagg aggcccagaa gattaacaat ggctcaagcc aggcggatgg cactctcaaa     1320

ccagtggatg aaaaagagga ggcagtggcc gccgaggtcg gctggatgac ctccgtgaag     1380

gactgggcgg gggtgatgat atccgcccag acactgactg gcagagtcct ggttgtctta     1440

gtctttgctc tcagcatcgg tgcacttgta atatacttca tagattcatc aaacccaata     1500

gaatcctgcc agaatttcta caaagatttc acattacaga tcgacatggc tttcaacgtg     1560

ttcttccttc tctactttgg cttgcggttt attgcagcca acgataaatt gtggttctgg     1620

ctggaagtga actctgtagt ggatttcttc acggtgcccc ccgtgtttgt gtctgtgtac     1680

ttaaacagaa gttggcttgg tttgagattt ttaagagctc tgagactgat acagttttca     1740

gaaattttgc agtttctgaa tattcttaaa acaagtaatt ccatcaagct ggtgaatctg     1800

ctctccatat ttatcagcac gtggctgact gcagctgggt tcatccattt ggtggagaat     1860

tcaggggacc catgggaaaa tttccaaaac aaccaggctc tcacctactg ggaatgtgtc     1920

tatttactca tggtcacaat gtccaccgtt ggttatgggg atgtttatgc aaaaaccaca     1980

cttcggcgcc tcttcatggt cttcttcatc ctcgggggac tggccatgtt tgccagctac     2040

gtccctgaaa tcatagagtt aataggaaac cgcaagaaat acgggggctc ctatagtgcg     2100

gttagtggaa gaaagcacat tgtggtctgc ggacacatca ctctggagag tgtttccaac     2160

ttcctgaagg actttctgca caaggaccgg gatgacgtca atgtggagat cgtttttctt     2220

cacaacatct cccccaacct ggagcttgaa gctctgttca aacgacattt tactcaggtg     2280

gaattttatc agggttccgt cctcaatcca catgatcttg caagagtcaa gatagagtca     2340

gcagatgcat gcctgatcct tgccaacaag tactgcgctg acccggatgc ggaggatgcc     2400

tcgaatatca tgagagtaat ctccataaag aactaccatc cgaagataag aatcatcact     2460

caaatgctgc agtatcacaa caaggcccat ctgctaaaca tcccgagctg gaattggaaa     2520

gaaggtgatg acgcaatctg cctcgcagag ttgaagttgg gcttcatagc ccagagctgc     2580

ctggctcaag gcctctccac catgcttgcc aacctcttct ccatgaggtc attcataaag     2640

attgaggaag acacatggca gaaatactac ttggaaggag tctcaaatga aatgtacaca     2700

gaatatctct ccagtgcctt cgtgggtctg tccttcccta ctgtttgtga gctgtgtttt     2760

gtgaagctca agctcctaat gatagccatt gagtacaagt ctgccaaccg agagagccgt     2820

atattaatta atcctggaaa ccatcttaag atccaagaag gtactttagg atttttcatc     2880

gcaagtgatg ccaaagaagt taaaagggca tttttttact gcaaggcctg tcatgatgac     2940

atcacagatc ccaaaagaat aaaaaaatgt ggctgcaaac ggcttgaaga tgagcagccg     3000

tcaacactat caccaaaaaa aaagcaacgg aatggaggca tgcggaactc acccaacacc     3060

tcgcctaagc tgatgaggca tgaccccttg ttaattcctg gcaatgatca gattgacaac     3120

atggactcca atgtgaagaa gtacgactct actgggatgt ttcactggtg tgcacccaag     3180

gagatagaga aagtcatcct gactcgaagt gaagctgcca tgaccgtcct gagtggccat     3240

gtcgtggtct gcatctttgg cgacgtcagc tcagccctga tcggcctccg gaacctggtg     3300

atgccgctcc gtgccagcaa ctttcattac catgagctca agcacattgt gtttgtgggc     3360

tctattgagt acctcaagcg ggaatgggag acgcttcata acttccccaa agtgtccata     3420

ttgcctggta cgccattaag tcgggctgat ttaagggctg tcaacatcaa cctctgtgac     3480

atgtgcgtta tcctgtcagc caatcagaat aatattgatg atacttcgct gcaggacaag     3540

gaatgcatct tggcgtcact caacatcaaa tctatgcagt ttgatgacag catcggagtc     3600

ttgcaggcta attcccaagg gttcacacct ccaggaatgg atagatcctc tccagataac     3660

agcccagtgc acgggatgtt acgtcaacca tccatcacaa ctggggtcaa catccccatc     3720

atcactgaac tagtgaacga tactaatgtt cagtttttgg accaagacga tgatgatgac     3780

cctgatacag aactgtacct cacgcagccc tttgcctgtg ggacagcatt tgccgtcagt     3840

gtcctggact cactcatgag cgcgacgtac ttcaatgaca atatcctcac cctgatacgg     3900

accctggtga ccggaggagc cacgccggag ctggaggctc tgattgctga ggaaaacgcc     3960

cttagaggtg gctacagcac cccgcagaca ctggccaata gggaccgctg ccgcgtggcc     4020

cagttagctc tgctcgatgg gccatttgcg gacttagggg atggtggttg ttatggtgat     4080

ctgttctgca aagctctgaa aacatataat atgctttgtt ttggaattta ccggctgaga     4140

gatgctcacc tcagcacccc cagtcagtgc acaaagaggt atgtcatcac caacccgccc     4200

tatgagtttg agctcgtgcc gacggacctg atcttctgct taatgcagtt tgaccacaat     4260

gccggccagt cccgggccag cctgtcccat tcctcccact cgtcgcagtc ctccagcaag     4320

aagagctcct ctgttcactc catcccatcc acagcaaacc gacagaaccg gcccaagtcc     4380

agggagtccc gggacaaaca gaagtacgtg caggaagagc ggctttgata tgtgtatcca     4440

ccgccactgt gtgaaactgt atctgccact catttcccca gttggtgttt ccaacaaagt     4500

aactttccct gttttcccct gtagtccccc cccttttttt ttacacatat ttgcatatgt     4560

atgatagtgt gcatgtggtt gtcattttta tttcaccacc ataaaaccct tgagcacaac     4620

agcaaataag cagacgggct ccggaattct gcagcccggg ggatccacta gttctagagg     4680

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     4740

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     4800

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     4860

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     4920

ggtgggctct atggcttcta ctgggcggtt ttatggacag caagcgaacc ggaattgcca     4980

gctggggcgc cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttctcg     5040

ccgccaagga tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg     5100

tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg     5160

ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg     5220

ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat     5280

gaactgcaag acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca     5340

gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg     5400

gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat     5460

gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa     5520

catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg     5580

gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg     5640

cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg     5700

gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat     5760

caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac     5820

cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc     5880

cttcttgacg agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc     5940

cttacgcatc tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc     6000

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     6060

aataaccctg ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa     6120

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     6180

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     6240

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     6300

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     6360

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     6420

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     6480

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     6540

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     6600

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     6660

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     6720

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     6780

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     6840

ggttcctggc cttttgctgg ccttttgctc acatgttctt                           6880


<210>  17
<211>  1236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 1

<400>  17

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Pro Lys Met Ser Ile Tyr Lys 
    690                 695                 700                 


Arg Met Arg Arg Ala Cys Cys Phe Asp Cys Gly Arg Ser Glu Arg Asp 
705                 710                 715                 720 


Cys Ser Cys Met Ser Gly Arg Val Arg Gly Asn Val Asp Thr Leu Glu 
                725                 730                 735     


Arg Ala Phe Pro Leu Ser Ser Val Ser Val Asn Asp Cys Ser Thr Ser 
            740                 745                 750         


Phe Arg Ala Phe Glu Asp Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys 
        755                 760                 765             


Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn Thr Ser Pro Lys 
    770                 775                 780                 


Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp 
785                 790                 795                 800 


Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr Gly Met Phe His 
                805                 810                 815     


Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu Thr Arg Ser Glu 
            820                 825                 830         


Ala Ala Met Thr Val Leu Ser Gly His Val Val Val Cys Ile Phe Gly 
        835                 840                 845             


Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val Met Pro Leu 
    850                 855                 860                 


Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile Val Phe Val 
865                 870                 875                 880 


Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu His Asn Phe 
                885                 890                 895     


Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu 
            900                 905                 910         


Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile Leu Ser Ala 
        915                 920                 925             


Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile 
    930                 935                 940                 


Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp Ser Ile Gly 
945                 950                 955                 960 


Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly Met Asp Arg 
                965                 970                 975     


Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg Gln Pro Ser 
            980                 985                 990         


Ile Thr Thr Gly Val Asn Ile Pro  Ile Ile Thr Glu Leu  Val Asn Asp 
        995                 1000                 1005             


Thr Asn  Val Gln Phe Leu Asp  Gln Asp Asp Asp Asp  Asp Pro Asp 
    1010                 1015                 1020             


Thr Glu  Leu Tyr Leu Thr Gln  Pro Phe Ala Cys Gly  Thr Ala Phe 
    1025                 1030                 1035             


Ala Val  Ser Val Leu Asp Ser  Leu Met Ser Ala Thr  Tyr Phe Asn 
    1040                 1045                 1050             


Asp Asn  Ile Leu Thr Leu Ile  Arg Thr Leu Val Thr  Gly Gly Ala 
    1055                 1060                 1065             


Thr Pro  Glu Leu Glu Ala Leu  Ile Ala Glu Glu Asn  Ala Leu Arg 
    1070                 1075                 1080             


Gly Gly  Tyr Ser Thr Pro Gln  Thr Leu Ala Asn Arg  Asp Arg Cys 
    1085                 1090                 1095             


Arg Val  Ala Gln Leu Ala Leu  Leu Asp Gly Pro Phe  Ala Asp Leu 
    1100                 1105                 1110             


Gly Asp  Gly Gly Cys Tyr Gly  Asp Leu Phe Cys Lys  Ala Leu Lys 
    1115                 1120                 1125             


Thr Tyr  Asn Met Leu Cys Phe  Gly Ile Tyr Arg Leu  Arg Asp Ala 
    1130                 1135                 1140             


His Leu  Ser Thr Pro Ser Gln  Cys Thr Lys Arg Tyr  Val Ile Thr 
    1145                 1150                 1155             


Asn Pro  Pro Tyr Glu Phe Glu  Leu Val Pro Thr Asp  Leu Ile Phe 
    1160                 1165                 1170             


Cys Leu  Met Gln Phe Asp His  Asn Ala Gly Gln Ser  Arg Ala Ser 
    1175                 1180                 1185             


Leu Ser  His Ser Ser His Ser  Ser Gln Ser Ser Ser  Lys Lys Ser 
    1190                 1195                 1200             


Ser Ser  Val His Ser Ile Pro  Ser Thr Ala Asn Arg  Gln Asn Arg 
    1205                 1210                 1215             


Pro Lys  Ser Arg Glu Ser Arg  Asp Lys Gln Lys Tyr  Val Gln Glu 
    1220                 1225                 1230             


Glu Arg  Leu 
    1235     


<210>  18
<211>  1219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 2

<400>  18

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser 
    690                 695                 700                 


Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser 
705                 710                 715                 720 


Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro 
                725                 730                 735     


Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp 
            740                 745                 750         


Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val 
        755                 760                 765             


Ile Leu Val Thr Gly Trp Met Pro Tyr Leu Gly Pro Arg Val Leu Met 
    770                 775                 780                 


Thr Cys Leu Asp Ile Gly Val Val Cys Met Pro Thr Asp Ile Gln Ser 
785                 790                 795                 800 


Thr Ser Pro Ala Ser Ile Lys Lys Phe Lys Glu Thr Arg Ser Glu Ala 
                805                 810                 815     


Ala Met Thr Val Leu Ser Gly His Val Val Val Cys Ile Phe Gly Asp 
            820                 825                 830         


Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val Met Pro Leu Arg 
        835                 840                 845             


Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile Val Phe Val Gly 
    850                 855                 860                 


Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu His Asn Phe Pro 
865                 870                 875                 880 


Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu Arg 
                885                 890                 895     


Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile Leu Ser Ala Asn 
            900                 905                 910         


Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile Leu 
        915                 920                 925             


Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp Ser Ile Gly Val 
    930                 935                 940                 


Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly Met Asp Arg Ser 
945                 950                 955                 960 


Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg Gln Pro Ser Ile 
                965                 970                 975     


Thr Thr Gly Val Asn Ile Pro Ile Ile Thr Glu Leu Val Asn Asp Thr 
            980                 985                 990         


Asn Val Gln Phe Leu Asp Gln Asp  Asp Asp Asp Asp Pro  Asp Thr Glu 
        995                 1000                 1005             


Leu Tyr  Leu Thr Gln Pro Phe  Ala Cys Gly Thr Ala  Phe Ala Val 
    1010                 1015                 1020             


Ser Val  Leu Asp Ser Leu Met  Ser Ala Thr Tyr Phe  Asn Asp Asn 
    1025                 1030                 1035             


Ile Leu  Thr Leu Ile Arg Thr  Leu Val Thr Gly Gly  Ala Thr Pro 
    1040                 1045                 1050             


Glu Leu  Glu Ala Leu Ile Ala  Glu Glu Asn Ala Leu  Arg Gly Gly 
    1055                 1060                 1065             


Tyr Ser  Thr Pro Gln Thr Leu  Ala Asn Arg Asp Arg  Cys Arg Val 
    1070                 1075                 1080             


Ala Gln  Leu Ala Leu Leu Asp  Gly Pro Phe Ala Asp  Leu Gly Asp 
    1085                 1090                 1095             


Gly Gly  Cys Tyr Gly Asp Leu  Phe Cys Lys Ala Leu  Lys Thr Tyr 
    1100                 1105                 1110             


Asn Met  Leu Cys Phe Gly Ile  Tyr Arg Leu Arg Asp  Ala His Leu 
    1115                 1120                 1125             


Ser Thr  Pro Ser Gln Cys Thr  Lys Arg Tyr Val Ile  Thr Asn Pro 
    1130                 1135                 1140             


Pro Tyr  Glu Phe Glu Leu Val  Pro Thr Asp Leu Ile  Phe Cys Leu 
    1145                 1150                 1155             


Met Gln  Phe Asp His Asn Ala  Gly Gln Ser Arg Ala  Ser Leu Ser 
    1160                 1165                 1170             


His Ser  Ser His Ser Ser Gln  Ser Ser Ser Lys Lys  Ser Ser Ser 
    1175                 1180                 1185             


Val His  Ser Ile Pro Ser Thr  Ala Asn Arg Gln Asn  Arg Pro Lys 
    1190                 1195                 1200             


Ser Arg  Glu Ser Arg Asp Lys  Gln Lys Tyr Val Gln  Glu Glu Arg 
    1205                 1210                 1215             


Leu 
    


<210>  19
<211>  1240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 3

<400>  19

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ser Arg Lys Arg Ile Leu Ile Asn Pro Gly Asn His Leu 
                645                 650                 655     


Lys Ile Gln Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys 
            660                 665                 670         


Glu Val Lys Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile 
        675                 680                 685             


Thr Asp Pro Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Pro Lys Met 
    690                 695                 700                 


Ser Ile Tyr Lys Arg Met Arg Arg Ala Cys Cys Phe Asp Cys Gly Arg 
705                 710                 715                 720 


Ser Glu Arg Asp Cys Ser Cys Met Ser Gly Arg Val Arg Gly Asn Val 
                725                 730                 735     


Asp Thr Leu Glu Arg Ala Phe Pro Leu Ser Ser Val Ser Val Asn Asp 
            740                 745                 750         


Cys Ser Thr Ser Phe Arg Ala Phe Glu Asp Glu Gln Pro Ser Thr Leu 
        755                 760                 765             


Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn 
    770                 775                 780                 


Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn 
785                 790                 795                 800 


Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr 
                805                 810                 815     


Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu 
            820                 825                 830         


Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val Val Val 
        835                 840                 845             


Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu 
    850                 855                 860                 


Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His 
865                 870                 875                 880 


Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr 
                885                 890                 895     


Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser 
            900                 905                 910         


Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val 
        915                 920                 925             


Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp 
    930                 935                 940                 


Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp 
945                 950                 955                 960 


Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro 
                965                 970                 975     


Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu 
            980                 985                 990         


Arg Gln Pro Ser Ile Thr Thr Gly  Val Asn Ile Pro Ile  Ile Thr Glu 
        995                 1000                 1005             


Leu Val  Asn Asp Thr Asn Val  Gln Phe Leu Asp Gln  Asp Asp Asp 
    1010                 1015                 1020             


Asp Asp  Pro Asp Thr Glu Leu  Tyr Leu Thr Gln Pro  Phe Ala Cys 
    1025                 1030                 1035             


Gly Thr  Ala Phe Ala Val Ser  Val Leu Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Thr Tyr  Phe Asn Asp Asn Ile  Leu Thr Leu Ile Arg  Thr Leu Val 
    1055                 1060                 1065             


Thr Gly  Gly Ala Thr Pro Glu  Leu Glu Ala Leu Ile  Ala Glu Glu 
    1070                 1075                 1080             


Asn Ala  Leu Arg Gly Gly Tyr  Ser Thr Pro Gln Thr  Leu Ala Asn 
    1085                 1090                 1095             


Arg Asp  Arg Cys Arg Val Ala  Gln Leu Ala Leu Leu  Asp Gly Pro 
    1100                 1105                 1110             


Phe Ala  Asp Leu Gly Asp Gly  Gly Cys Tyr Gly Asp  Leu Phe Cys 
    1115                 1120                 1125             


Lys Ala  Leu Lys Thr Tyr Asn  Met Leu Cys Phe Gly  Ile Tyr Arg 
    1130                 1135                 1140             


Leu Arg  Asp Ala His Leu Ser  Thr Pro Ser Gln Cys  Thr Lys Arg 
    1145                 1150                 1155             


Tyr Val  Ile Thr Asn Pro Pro  Tyr Glu Phe Glu Leu  Val Pro Thr 
    1160                 1165                 1170             


Asp Leu  Ile Phe Cys Leu Met  Gln Phe Asp His Asn  Ala Gly Gln 
    1175                 1180                 1185             


Ser Arg  Ala Ser Leu Ser His  Ser Ser His Ser Ser  Gln Ser Ser 
    1190                 1195                 1200             


Ser Lys  Lys Ser Ser Ser Val  His Ser Ile Pro Ser  Thr Ala Asn 
    1205                 1210                 1215             


Arg Gln  Asn Arg Pro Lys Ser  Arg Glu Ser Arg Asp  Lys Gln Lys 
    1220                 1225                 1230             


Tyr Val  Gln Glu Glu Arg Leu  
    1235                 1240 


<210>  20
<211>  1207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 4

<400>  20

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Lys Val Ala Ala Arg Ser 
    690                 695                 700                 


Arg Tyr Ser Lys Asp Pro Phe Glu Phe Lys Lys Glu Thr Pro Asn Ser 
705                 710                 715                 720 


Arg Leu Val Thr Glu Pro Val Glu Asp Glu Gln Pro Ser Thr Leu Ser 
                725                 730                 735     


Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn Thr 
            740                 745                 750         


Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn Asp 
        755                 760                 765             


Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr Gly 
    770                 775                 780                 


Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu Thr 
785                 790                 795                 800 


Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val Val Val Cys 
                805                 810                 815     


Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val 
            820                 825                 830         


Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile 
        835                 840                 845             


Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu 
    850                 855                 860                 


His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg 
865                 870                 875                 880 


Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile 
                885                 890                 895     


Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys 
            900                 905                 910         


Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp 
        915                 920                 925             


Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly 
    930                 935                 940                 


Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg 
945                 950                 955                 960 


Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile Ile Thr Glu Leu 
                965                 970                 975     


Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp Asp Asp Asp 
            980                 985                 990         


Pro Asp Thr Glu Leu Tyr Leu Thr  Gln Pro Phe Ala Cys  Gly Thr Ala 
        995                 1000                 1005             


Phe Ala  Val Ser Val Leu Asp  Ser Leu Met Ser Ala  Thr Tyr Phe 
    1010                 1015                 1020             


Asn Asp  Asn Ile Leu Thr Leu  Ile Arg Thr Leu Val  Thr Gly Gly 
    1025                 1030                 1035             


Ala Thr  Pro Glu Leu Glu Ala  Leu Ile Ala Glu Glu  Asn Ala Leu 
    1040                 1045                 1050             


Arg Gly  Gly Tyr Ser Thr Pro  Gln Thr Leu Ala Asn  Arg Asp Arg 
    1055                 1060                 1065             


Cys Arg  Val Ala Gln Leu Ala  Leu Leu Asp Gly Pro  Phe Ala Asp 
    1070                 1075                 1080             


Leu Gly  Asp Gly Gly Cys Tyr  Gly Asp Leu Phe Cys  Lys Ala Leu 
    1085                 1090                 1095             


Lys Thr  Tyr Asn Met Leu Cys  Phe Gly Ile Tyr Arg  Leu Arg Asp 
    1100                 1105                 1110             


Ala His  Leu Ser Thr Pro Ser  Gln Cys Thr Lys Arg  Tyr Val Ile 
    1115                 1120                 1125             


Thr Asn  Pro Pro Tyr Glu Phe  Glu Leu Val Pro Thr  Asp Leu Ile 
    1130                 1135                 1140             


Phe Cys  Leu Met Gln Phe Asp  His Asn Ala Gly Gln  Ser Arg Ala 
    1145                 1150                 1155             


Ser Leu  Ser His Ser Ser His  Ser Ser Gln Ser Ser  Ser Lys Lys 
    1160                 1165                 1170             


Ser Ser  Ser Val His Ser Ile  Pro Ser Thr Ala Asn  Arg Gln Asn 
    1175                 1180                 1185             


Arg Pro  Lys Ser Arg Glu Ser  Arg Asp Lys Gln Lys  Tyr Val Gln 
    1190                 1195                 1200             


Glu Glu  Arg Leu 
    1205         


<210>  21
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 5

<400>  21

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser 
    690                 695                 700                 


Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser 
705                 710                 715                 720 


Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro 
                725                 730                 735     


Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp 
            740                 745                 750         


Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val 
        755                 760                 765             


Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val 
    770                 775                 780                 


Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg 
785                 790                 795                 800 


Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu 
                805                 810                 815     


Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp 
            820                 825                 830         


Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro 
        835                 840                 845             


Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met 
    850                 855                 860                 


Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu 
865                 870                 875                 880 


Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln 
                885                 890                 895     


Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr 
            900                 905                 910         


Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly 
        915                 920                 925             


Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile Ile 
    930                 935                 940                 


Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp 
945                 950                 955                 960 


Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala Cys 
                965                 970                 975     


Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala Thr 
            980                 985                 990         


Tyr Phe Asn Asp Asn Ile Leu Thr  Leu Ile Arg Thr Leu  Val Thr Gly 
        995                 1000                 1005             


Gly Ala  Thr Pro Glu Leu Glu  Ala Leu Ile Ala Glu  Glu Asn Ala 
    1010                 1015                 1020             


Leu Arg  Gly Gly Tyr Ser Thr  Pro Gln Thr Leu Ala  Asn Arg Asp 
    1025                 1030                 1035             


Arg Cys  Arg Val Ala Gln Leu  Ala Leu Leu Asp Gly  Pro Phe Ala 
    1040                 1045                 1050             


Asp Leu  Gly Asp Gly Gly Cys  Tyr Gly Asp Leu Phe  Cys Lys Ala 
    1055                 1060                 1065             


Leu Lys  Thr Tyr Asn Met Leu  Cys Phe Gly Ile Tyr  Arg Leu Arg 
    1070                 1075                 1080             


Asp Ala  His Leu Ser Thr Pro  Ser Gln Cys Thr Lys  Arg Tyr Val 
    1085                 1090                 1095             


Ile Thr  Asn Pro Pro Tyr Glu  Phe Glu Leu Val Pro  Thr Asp Leu 
    1100                 1105                 1110             


Ile Phe  Cys Leu Met Gln Phe  Asp His Asn Ala Gly  Gln Ser Arg 
    1115                 1120                 1125             


Ala Ser  Leu Ser His Ser Ser  His Ser Ser Gln Ser  Ser Ser Lys 
    1130                 1135                 1140             


Lys Ser  Ser Ser Val His Ser  Ile Pro Ser Thr Ala  Asn Arg Gln 
    1145                 1150                 1155             


Asn Arg  Pro Lys Ser Arg Glu  Ser Arg Asp Lys Gln  Lys Tyr Val 
    1160                 1165                 1170             


Gln Glu  Glu Arg Leu 
    1175             


<210>  22
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 6

<400>  22

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Ala Thr 
        115                 120                 125             


His Phe Gly Ser Pro Glu Met Pro Pro Ala Ala Arg Ser Trp Ser Gly 
    130                 135                 140                 


Ser Pro Pro Glu Ala Ala Val Leu Arg Gly Ala Ser Ser Leu Ala Leu 
145                 150                 155                 160 


Glu Val Ala Arg Cys Arg Arg Leu 
                165             


<210>  23
<211>  1239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K alpha subunit (Slo), isoform 7

<400>  23

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Arg Trp Glu Glu His Cys Ser 
    690                 695                 700                 


Leu Trp Arg Leu Glu Ser Lys Gly Asn Val Arg Arg Leu Asn Tyr Cys 
705                 710                 715                 720 


Arg Gly Gln Gln Thr Phe Ser Val Lys Val Lys Val Ala Ala Arg Ser 
                725                 730                 735     


Arg Tyr Ser Lys Asp Pro Phe Glu Phe Lys Lys Glu Thr Pro Asn Ser 
            740                 745                 750         


Arg Leu Val Thr Glu Pro Val Glu Asp Glu Gln Pro Ser Thr Leu Ser 
        755                 760                 765             


Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn Thr 
    770                 775                 780                 


Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn Asp 
785                 790                 795                 800 


Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr Gly 
                805                 810                 815     


Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu Thr 
            820                 825                 830         


Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val Val Val Cys 
        835                 840                 845             


Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val 
    850                 855                 860                 


Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile 
865                 870                 875                 880 


Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu 
                885                 890                 895     


His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg 
            900                 905                 910         


Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile 
        915                 920                 925             


Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys 
    930                 935                 940                 


Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp 
945                 950                 955                 960 


Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly 
                965                 970                 975     


Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg 
            980                 985                 990         


Gln Pro Ser Ile Thr Thr Gly Val  Asn Ile Pro Ile Ile  Thr Glu Leu 
        995                 1000                 1005             


Val Asn  Asp Thr Asn Val Gln  Phe Leu Asp Gln Asp  Asp Asp Asp 
    1010                 1015                 1020             


Asp Pro  Asp Thr Glu Leu Tyr  Leu Thr Gln Pro Phe  Ala Cys Gly 
    1025                 1030                 1035             


Thr Ala  Phe Ala Val Ser Val  Leu Asp Ser Leu Met  Ser Ala Thr 
    1040                 1045                 1050             


Tyr Phe  Asn Asp Asn Ile Leu  Thr Leu Ile Arg Thr  Leu Val Thr 
    1055                 1060                 1065             


Gly Gly  Ala Thr Pro Glu Leu  Glu Ala Leu Ile Ala  Glu Glu Asn 
    1070                 1075                 1080             


Ala Leu  Arg Gly Gly Tyr Ser  Thr Pro Gln Thr Leu  Ala Asn Arg 
    1085                 1090                 1095             


Asp Arg  Cys Arg Val Ala Gln  Leu Ala Leu Leu Asp  Gly Pro Phe 
    1100                 1105                 1110             


Ala Asp  Leu Gly Asp Gly Gly  Cys Tyr Gly Asp Leu  Phe Cys Lys 
    1115                 1120                 1125             


Ala Leu  Lys Thr Tyr Asn Met  Leu Cys Phe Gly Ile  Tyr Arg Leu 
    1130                 1135                 1140             


Arg Asp  Ala His Leu Ser Thr  Pro Ser Gln Cys Thr  Lys Arg Tyr 
    1145                 1150                 1155             


Val Ile  Thr Asn Pro Pro Tyr  Glu Phe Glu Leu Val  Pro Thr Asp 
    1160                 1165                 1170             


Leu Ile  Phe Cys Leu Met Gln  Phe Asp His Asn Ala  Gly Gln Ser 
    1175                 1180                 1185             


Arg Ala  Ser Leu Ser His Ser  Ser His Ser Ser Gln  Ser Ser Ser 
    1190                 1195                 1200             


Lys Lys  Ser Ser Ser Val His  Ser Ile Pro Ser Thr  Ala Asn Arg 
    1205                 1210                 1215             


Gln Asn  Arg Pro Lys Ser Arg  Glu Ser Arg Asp Lys  Gln Lys Tyr 
    1220                 1225                 1230             


Val Gln  Glu Glu Arg Leu 
    1235                 


<210>  24
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 1 subunit (Slo), isoform 1

<400>  24

Met Val Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala 
1               5                   10                  15      


Leu Cys Leu Gly Val Thr Met Val Val Cys Ala Val Ile Thr Tyr Tyr 
            20                  25                  30          


Ile Leu Val Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr 
        35                  40                  45              


Gln Glu Ser Lys Cys His Leu Ile Glu Thr Asn Ile Arg Asp Gln Glu 
    50                  55                  60                  


Glu Leu Lys Gly Lys Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn 
65                  70                  75                  80  


Val Ser Ala Ala Gly Arg Trp Ala Val Leu Tyr His Thr Glu Asp Thr 
                85                  90                  95      


Arg Asp Gln Asn Gln Gln Cys Ser Tyr Ile Pro Gly Ser Val Asp Asn 
            100                 105                 110         


Tyr Gln Thr Ala Arg Ala Asp Val Glu Lys Val Arg Ala Lys Phe Gln 
        115                 120                 125             


Glu Gln Gln Val Phe Tyr Cys Phe Ser Ala Pro Arg Gly Asn Glu Thr 
    130                 135                 140                 


Ser Val Leu Phe Gln Arg Leu Tyr Gly Pro Gln Ala Leu Leu Phe Ser 
145                 150                 155                 160 


Leu Phe Trp Pro Thr Phe Leu Leu Thr Gly Gly Leu Leu Ile Ile Ala 
                165                 170                 175     


Met Val Lys Ser Asn Gln Tyr Leu Ser Ile Leu Ala Ala Gln Lys 
            180                 185                 190     


<210>  25
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 1 subunit (Slo), isoform 2

<400>  25

Met Val Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala 
1               5                   10                  15      


Leu Cys Leu Gly Val Thr Met Val Val Cys Ala Val Ile Thr Tyr Tyr 
            20                  25                  30          


Ile Leu Val Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr 
        35                  40                  45              


Gln Glu Ser Lys Cys His Leu Ile Glu Thr Asn Ile Arg Asp Gln Glu 
    50                  55                  60                  


Glu Leu Lys Gly Lys Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn 
65                  70                  75                  80  


Val Ser Ala Ala Gly Arg Trp Ala Val Leu Tyr His Thr Glu Asp Thr 
                85                  90                  95      


Arg Asp Gln Asn Gln Gln Val Leu Asn Trp Arg Asp Gly Asp Thr Ser 
            100                 105                 110         


Leu Tyr Pro Cys Gln Val Cys Glu Pro Val Pro Asn Cys Pro Cys Pro 
        115                 120                 125             


Arg Gly 
    130 


<210>  26
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 2 subunit (Slo)

<400>  26

Met Phe Ile Trp Thr Ser Gly Arg Thr Ser Ser Ser Tyr Arg His Asp 
1               5                   10                  15      


Glu Lys Arg Asn Ile Tyr Gln Lys Ile Arg Asp His Asp Leu Leu Asp 
            20                  25                  30          


Lys Arg Lys Thr Val Thr Ala Leu Lys Ala Gly Glu Asp Arg Ala Ile 
        35                  40                  45              


Leu Leu Gly Leu Ala Met Met Val Cys Ser Ile Met Met Tyr Phe Leu 
    50                  55                  60                  


Leu Gly Ile Thr Leu Leu Arg Ser Tyr Met Gln Ser Val Trp Thr Glu 
65                  70                  75                  80  


Glu Ser Gln Cys Thr Leu Leu Asn Ala Ser Ile Thr Glu Thr Phe Asn 
                85                  90                  95      


Cys Ser Phe Ser Cys Gly Pro Asp Cys Trp Lys Leu Ser Gln Tyr Pro 
            100                 105                 110         


Cys Leu Gln Val Tyr Val Asn Leu Thr Ser Ser Gly Glu Lys Leu Leu 
        115                 120                 125             


Leu Tyr His Thr Glu Glu Thr Ile Lys Ile Asn Gln Lys Cys Ser Tyr 
    130                 135                 140                 


Ile Pro Lys Cys Gly Lys Asn Phe Glu Glu Ser Met Ser Leu Val Asn 
145                 150                 155                 160 


Val Val Met Glu Asn Phe Arg Lys Tyr Gln His Phe Ser Cys Tyr Ser 
                165                 170                 175     


Asp Pro Glu Gly Asn Gln Lys Ser Val Ile Leu Thr Lys Leu Tyr Ser 
            180                 185                 190         


Ser Asn Val Leu Phe His Ser Leu Phe Trp Pro Thr Cys Met Met Ala 
        195                 200                 205             


Gly Gly Val Ala Ile Val Ala Met Val Lys Leu Thr Gln Tyr Leu Ser 
    210                 215                 220                 


Leu Leu Cys Glu Arg Ile Gln Arg Ile Asn Arg 
225                 230                 235 


<210>  27
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 3 subunit (Slo), isoform 1

<400>  27

Met Asp Phe Ser Pro Ser Ser Glu Leu Gly Phe His Phe Val Ala Phe 
1               5                   10                  15      


Ile Leu Leu Thr Arg His Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys 
            20                  25                  30          


Arg Glu Thr Asp Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg 
        35                  40                  45              


Leu Pro Ser Ser Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala 
    50                  55                  60                  


Met Met Gly Phe Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile 
65                  70                  75                  80  


Leu Lys Pro Phe Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr 
                85                  90                  95      


Ala Ile His Thr Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr 
            100                 105                 110         


Cys Gly Val His Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val 
        115                 120                 125             


Phe Val Asn Leu Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn 
    130                 135                 140                 


Glu Glu Ala Val Gln Ile Asn Pro Lys Cys Phe Tyr Thr Pro Lys Cys 
145                 150                 155                 160 


His Gln Asp Arg Asn Asp Leu Leu Asn Ser Ala Leu Asp Ile Lys Glu 
                165                 170                 175     


Phe Phe Asp His Lys Asn Gly Thr Pro Phe Ser Cys Phe Tyr Ser Pro 
            180                 185                 190         


Ala Ser Gln Ser Glu Asp Val Ile Leu Ile Lys Lys Tyr Asp Gln Met 
        195                 200                 205             


Ala Ile Phe His Cys Leu Phe Trp Pro Ser Leu Thr Leu Leu Gly Gly 
    210                 215                 220                 


Ala Leu Ile Val Gly Met Val Arg Leu Thr Gln His Leu Ser Leu Leu 
225                 230                 235                 240 


Cys Glu Lys Tyr Ser Thr Val Val Arg Asp Glu Val Gly Gly Lys Val 
                245                 250                 255     


Pro Tyr Ile Glu Gln His Gln Phe Lys Leu Cys Ile Met Arg Arg Ser 
            260                 265                 270         


Lys Gly Arg Ala Glu Lys Ser 
        275                 


<210>  28
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 3 subunit (Slo), isoform 2

<400>  28

Met Gln Pro Phe Ser Ile Pro Val Gln Ile Thr Leu Gln Gly Ser Arg 
1               5                   10                  15      


Arg Arg Gln Gly Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu 
            20                  25                  30          


Thr Asp Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro 
        35                  40                  45              


Ser Ser Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met 
    50                  55                  60                  


Gly Phe Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys 
65                  70                  75                  80  


Pro Phe Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile 
                85                  90                  95      


His Thr Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly 
            100                 105                 110         


Val His Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val 
        115                 120                 125             


Asn Leu Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu 
    130                 135                 140                 


Ala Val Gln Ile Asn Pro Lys Cys Phe Tyr Thr Pro Lys Cys His Gln 
145                 150                 155                 160 


Asp Arg Asn Asp Leu Leu Asn Ser Ala Leu Asp Ile Lys Glu Phe Phe 
                165                 170                 175     


Asp His Lys Asn Gly Thr Pro Phe Ser Cys Phe Tyr Ser Pro Ala Ser 
            180                 185                 190         


Gln Ser Glu Asp Val Ile Leu Ile Lys Lys Tyr Asp Gln Met Ala Ile 
        195                 200                 205             


Phe His Cys Leu Phe Trp Pro Ser Leu Thr Leu Leu Gly Gly Ala Leu 
    210                 215                 220                 


Ile Val Gly Met Val Arg Leu Thr Gln His Leu Ser Leu Leu Cys Glu 
225                 230                 235                 240 


Lys Tyr Ser Thr Val Val Arg Asp Glu Val Gly Gly Lys Val Pro Tyr 
                245                 250                 255     


Ile Glu Gln His Gln Phe Lys Leu Cys Ile Met Arg Arg Ser Lys Gly 
            260                 265                 270         


Arg Ala Glu Lys Ser 
        275         


<210>  29
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 3 subunit (Slo), isoform 3

<400>  29

Met Phe Pro Leu Leu Tyr Glu Leu Thr Ala Val Ser Pro Ser Pro Phe 
1               5                   10                  15      


Pro Gln Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu Thr Asp 
            20                  25                  30          


Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro Ser Ser 
        35                  40                  45              


Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met Gly Phe 
    50                  55                  60                  


Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys Pro Phe 
65                  70                  75                  80  


Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile His Thr 
                85                  90                  95      


Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly Val His 
            100                 105                 110         


Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val Asn Leu 
        115                 120                 125             


Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu Ala Val 
    130                 135                 140                 


Gln Ile Asn Pro Lys Cys Phe Tyr Thr Pro Lys Cys His Gln Asp Arg 
145                 150                 155                 160 


Asn Asp Leu Leu Asn Ser Ala Leu Asp Ile Lys Glu Phe Phe Asp His 
                165                 170                 175     


Lys Asn Gly Thr Pro Phe Ser Cys Phe Tyr Ser Pro Ala Ser Gln Ser 
            180                 185                 190         


Glu Asp Val Ile Leu Ile Lys Lys Tyr Asp Gln Met Ala Ile Phe His 
        195                 200                 205             


Cys Leu Phe Trp Pro Ser Leu Thr Leu Leu Gly Gly Ala Leu Ile Val 
    210                 215                 220                 


Gly Met Val Arg Leu Thr Gln His Leu Ser Leu Leu Cys Glu Lys Tyr 
225                 230                 235                 240 


Ser Thr Val Val Arg Asp Glu Val Gly Gly Lys Val Pro Tyr Ile Glu 
                245                 250                 255     


Gln His Gln Phe Lys Leu Cys Ile Met Arg Arg Ser Lys Gly Arg Ala 
            260                 265                 270         


Glu Lys Ser 
        275 


<210>  30
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 3 subunit (Slo), isoform 4

<400>  30

Met Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu Thr Asp Tyr Ser 
1               5                   10                  15      


Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro Ser Ser Ala Gly 
            20                  25                  30          


Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met Gly Phe Ser Val 
        35                  40                  45              


Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys Pro Phe Met Leu 
    50                  55                  60                  


Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile His Thr Asp Ile 
65                  70                  75                  80  


Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly Val His Cys His 
                85                  90                  95      


Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val Asn Leu Ser His 
            100                 105                 110         


Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu Ala Val Gln Ile 
        115                 120                 125             


Asn Pro Lys Cys Phe Tyr Thr Pro Lys Cys His Gln Asp Arg Asn Asp 
    130                 135                 140                 


Leu Leu Asn Ser Ala Leu Asp Ile Lys Glu Phe Phe Asp His Lys Asn 
145                 150                 155                 160 


Gly Thr Pro Phe Ser Cys Phe Tyr Ser Pro Ala Ser Gln Ser Glu Asp 
                165                 170                 175     


Val Ile Leu Ile Lys Lys Tyr Asp Gln Met Ala Ile Phe His Cys Leu 
            180                 185                 190         


Phe Trp Pro Ser Leu Thr Leu Leu Gly Gly Ala Leu Ile Val Gly Met 
        195                 200                 205             


Val Arg Leu Thr Gln His Leu Ser Leu Leu Cys Glu Lys Tyr Ser Thr 
    210                 215                 220                 


Val Val Arg Asp Glu Val Gly Gly Lys Val Pro Tyr Ile Glu Gln His 
225                 230                 235                 240 


Gln Phe Lys Leu Cys Ile Met Arg Arg Ser Lys Gly Arg Ala Glu Lys 
                245                 250                 255     


Ser 
    


<210>  31
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 3 subunit (Slo), isoform 5

<400>  31

Met Gln Pro Phe Ser Ile Pro Val Gln Ile Thr Leu Gln Gly Ser Arg 
1               5                   10                  15      


Arg Arg Gln Gly Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu 
            20                  25                  30          


Thr Asp Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro 
        35                  40                  45              


Ser Ser Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met 
    50                  55                  60                  


Gly Phe Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys 
65                  70                  75                  80  


Pro Phe Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile 
                85                  90                  95      


His Thr Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly 
            100                 105                 110         


Val His Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val 
        115                 120                 125             


Asn Leu Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu 
    130                 135                 140                 


Ala Val Gln Ile Asn Pro Lys Arg Asp Val Thr Asp Cys Arg Val Lys 
145                 150                 155                 160 


Glu Lys Gln Thr Leu Thr Val Ser Asp Glu His Lys Gln 
                165                 170             


<210>  32
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maxi-K beta 4 subunit (Slo)

<400>  32

Met Ala Lys Leu Arg Val Ala Tyr Glu Tyr Thr Glu Ala Glu Asp Lys 
1               5                   10                  15      


Ser Ile Arg Leu Gly Leu Phe Leu Ile Ile Ser Gly Val Val Ser Leu 
            20                  25                  30          


Phe Ile Phe Gly Phe Cys Trp Leu Ser Pro Ala Leu Gln Asp Leu Gln 
        35                  40                  45              


Ala Thr Glu Ala Asn Cys Thr Val Leu Ser Val Gln Gln Ile Gly Glu 
    50                  55                  60                  


Val Phe Glu Cys Thr Phe Thr Cys Gly Ala Asp Cys Arg Gly Thr Ser 
65                  70                  75                  80  


Gln Tyr Pro Cys Val Gln Val Tyr Val Asn Asn Ser Glu Ser Asn Ser 
                85                  90                  95      


Arg Ala Leu Leu His Ser Asp Glu His Gln Leu Leu Thr Asn Pro Lys 
            100                 105                 110         


Cys Ser Tyr Ile Pro Pro Cys Lys Arg Glu Asn Gln Lys Asn Leu Glu 
        115                 120                 125             


Ser Val Met Asn Trp Gln Gln Tyr Trp Lys Asp Glu Ile Gly Ser Gln 
    130                 135                 140                 


Pro Phe Thr Cys Tyr Phe Asn Gln His Gln Arg Pro Asp Asp Val Leu 
145                 150                 155                 160 


Leu His Arg Thr His Asp Glu Ile Val Leu Leu His Cys Phe Leu Trp 
                165                 170                 175     


Pro Leu Val Thr Phe Val Val Gly Val Leu Ile Val Val Leu Thr Ile 
            180                 185                 190         


Cys Ala Lys Ser Leu Ala Val Lys Ala Glu Ala Met Lys Lys Arg Lys 
        195                 200                 205             


Phe Ser 
    210 


<210>  33
<211>  3711
<212>  DNA
<213>  Homo sapiens

<400>  33
atggcaaatg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggaggc       60

agcagtctta gaatgagtag caatatccac gcgaaccatc tcagcctaga cgcgtcctcc      120

tcctcctcct cctcctcttc ctcttcttct tcttcctcct cctcttcctc ctcgtcctcg      180

gtccacgagc ccaagatgga tgcgctcatc atcccggtga ccatggaggt gccgtgcgac      240

agccggggcc aacgcatgtg gtgggctttc ctggcctcct ccatggtgac tttcttcggg      300

ggcctcttca tcatcttgct ctggcggacg ctcaagtacc tgtggaccgt gtgctgccac      360

tgcgggggca agacgaagga ggcccagaag attaacaatg gctcaagcca ggcggatggc      420

actctcaaac cagtggatga aaaagaggag gcagtggccg ccgaggtcgg ctggatgacc      480

tccgtgaagg actgggcggg ggtgatgata tccgcccaga cactgactgg cagagtcctg      540

gttgtcttag tctttgctct cagcatcggt gcacttgtaa tatacttcat agattcatca      600

aacccaatag aatcctgcca gaatttctac aaagatttca cattacagat cgacatggct      660

ttcaacgtgt tcttccttct ctacttcggc ttgcggttta ttgcagccaa cgataaattg      720

tggttctggc tggaagtgaa ctctgtagtg gatttcttca cggtgccccc cgtgtttgtg      780

tctgtgtact taaacagaag ttggcttggt ttgagatttt taagagctct gagactgata      840

cagttttcag aaattttgca gtttctgaat attcttaaaa caagtaattc catcaagctg      900

gtgaatctgc tctccatatt tatcagcacg tggctgactg cagccgggtt catccatttg      960

gtggagaatt caggggaccc atgggaaaat ttccaaaaca accaggctct cacctactgg     1020

gaatgtgtct atttactcat ggtcacaatg tccaccgttg gttatgggga tgtttatgca     1080

aaaaccacac ttgggcgcct cttcatggtc ttcttcatcc tcgggggact ggccatgttt     1140

gccagctacg tccctgaaat catagagtta ataggaaacc gcaagaaata cgggggctcc     1200

tatagtgcgg ttagtggaag aaagcacatt gtggtctgcg gacacatcac tctggagagt     1260

gtttccaact tcctgaagga ctttctgcac aaggaccggg atgacgtcaa tgtggagatc     1320

gtttttcttc acaacatctc ccccaacctg gagcttgaag ctctgttcaa acgacatttt     1380

actcaggtgg aattttatca gggttccgtc ctcaatccac atgatcttgc aagagtcaag     1440

atagagtcag cagatgcatg cctgatcctt gccaacaagt actgcgctga cccggatgcg     1500

gaggatgcct cgaatatcat gagagtaatc tccataaaga actaccatcc gaagataaga     1560

atcatcactc aaatgctgca gtatcacaac aaggcccatc tgctaaacat cccgagctgg     1620

aattggaaag aaggtgatga cgcaatctgc ctcgcagagt tgaagttggg cttcatagcc     1680

cagagctgcc tggctcaagg cctctccacc atgcttgcca acctcttctc catgaggtca     1740

ttcataaaga ttgaggaaga cacatggcag aaatactact tggaaggagt ctcaaatgaa     1800

atgtacacag aatatctctc cagtgccttc gtgggtctgt ccttccctac tgtttgtgag     1860

ctgtgttttg tgaagctcaa gctcctaatg atagccattg agtacaagtc tgccaaccga     1920

gagagccgta tattaattaa tcctggaaac catcttaaga tccaagaagg tactttagga     1980

tttttcatcg caagtgatgc caaagaagtt aaaagggcat ttttttactg caaggcctgt     2040

catgatgaca tcacagatcc caaaagaata aaaaaatgtg gctgcaaacg gcccaagatg     2100

tccatctaca agagaatgag acgggcatgt tgttttgatt gcggacgttc tgagcgtgac     2160

tgctcatgca tgtcaggccg tgtgcgtggt aacgtggaca cccttgagag agccttccca     2220

ctttcttctg tctctgttaa tgattgctcc accagtttcc gtgcctttga agatgagcag     2280

ccgtcaacac tatcaccaaa aaaaaagcaa cggaatggag gcatgcggaa ctcacccaac     2340

acctcgccta agctgatgag gcatgacccc ttgttaattc ctggcaatga tcagattgac     2400

aacatggact ccaatgtgaa gaagtacgac tctactggga tgtttcactg gtgtgcaccc     2460

aaggagatag agaaagtcat cctgactcga agtgaagctg ccatgaccgt cctgagtggc     2520

catgtcgtgg tctgcatctt tggcgacgtc agctcagccc tgatcggcct ccggaacctg     2580

gtgatgccgc tccgtgccag caactttcat taccatgagc tcaagcacat tgtgtttgtg     2640

ggctctattg agtacctcaa gcgggaatgg gagacgcttc ataacttccc caaagtgtcc     2700

atattgcctg gtacgccatt aagtcgggct gatttaaggg ctgtcaacat caacctctgt     2760

gacatgtgcg ttatcctgtc agccaatcag aataatattg atgatacttc gctgcaggac     2820

aaggaatgca tcttggcgtc actcaacatc aaatctatgc agtttgatga cagcatcgga     2880

gtcttgcagg ctaattccca agggttcaca cctccaggaa tggatagatc ctctccagat     2940

aacagcccag tgcacgggat gttacgtcaa ccatccatca caactggggt caacatcccc     3000

atcatcactg aactagtgaa cgatactaat gttcagtttt tggaccaaga cgatgatgat     3060

gaccctgata cagaactgta cctcacgcag ccctttgcct gtgggacagc atttgccgtc     3120

agtgtcctgg actcactcat gagcgcgacg tacttcaatg acaatatcct caccctgata     3180

cggaccctgg tgaccggagg agccacgccg gagctggagg ctctgattgc tgaggaaaac     3240

gcccttagag gtggctacag caccccgcag acactggcca atagggaccg ctgccgcgtg     3300

gcccagttag ctctgctcga tgggccattt gcggacttag gggatggtgg ttgttatggt     3360

gatctgttct gcaaagctct gaaaacatat aatatgcttt gttttggaat ttaccggctg     3420

agagatgctc acctcagcac ccccagtcag tgcacaaaga ggtatgtcat caccaacccg     3480

ccctatgagt ttgagctcgt gccgacggac ctgatcttct gcttaatgca gtttgaccac     3540

aatgccggcc agtcccgggc cagcctgtcc cattcctccc actcgtcgca gtcctccagc     3600

aagaagagct cctctgttca ctccatccca tccacagcaa accgacagaa ccggcccaag     3660

tccagggagt cccgggacaa acagaagtac gtgcaggaag agcggctttg a              3711


<210>  34
<211>  3660
<212>  DNA
<213>  Homo sapiens

<400>  34
atggcaaatg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggaggc       60

agcagtctta gaatgagtag caatatccac gcgaaccatc tcagcctaga cgcgtcctcc      120

tcctcctcct cctcctcttc ctcttcttct tcttcctcct cctcttcctc ctcgtcctcg      180

gtccacgagc ccaagatgga tgcgctcatc atcccggtga ccatggaggt gccgtgcgac      240

agccggggcc aacgcatgtg gtgggctttc ctggcctcct ccatggtgac tttcttcggg      300

ggcctcttca tcatcttgct ctggcggacg ctcaagtacc tgtggaccgt gtgctgccac      360

tgcgggggca agacgaagga ggcccagaag attaacaatg gctcaagcca ggcggatggc      420

actctcaaac cagtggatga aaaagaggag gcagtggccg ccgaggtcgg ctggatgacc      480

tccgtgaagg actgggcggg ggtgatgata tccgcccaga cactgactgg cagagtcctg      540

gttgtcttag tctttgctct cagcatcggt gcacttgtaa tatacttcat agattcatca      600

aacccaatag aatcctgcca gaatttctac aaagatttca cattacagat cgacatggct      660

ttcaacgtgt tcttccttct ctacttcggc ttgcggttta ttgcagccaa cgataaattg      720

tggttctggc tggaagtgaa ctctgtagtg gatttcttca cggtgccccc cgtgtttgtg      780

tctgtgtact taaacagaag ttggcttggt ttgagatttt taagagctct gagactgata      840

cagttttcag aaattttgca gtttctgaat attcttaaaa caagtaattc catcaagctg      900

gtgaatctgc tctccatatt tatcagcacg tggctgactg cagccgggtt catccatttg      960

gtggagaatt caggggaccc atgggaaaat ttccaaaaca accaggctct cacctactgg     1020

gaatgtgtct atttactcat ggtcacaatg tccaccgttg gttatgggga tgtttatgca     1080

aaaaccacac ttgggcgcct cttcatggtc ttcttcatcc tcgggggact ggccatgttt     1140

gccagctacg tccctgaaat catagagtta ataggaaacc gcaagaaata cgggggctcc     1200

tatagtgcgg ttagtggaag aaagcacatt gtggtctgcg gacacatcac tctggagagt     1260

gtttccaact tcctgaagga ctttctgcac aaggaccggg atgacgtcaa tgtggagatc     1320

gtttttcttc acaacatctc ccccaacctg gagcttgaag ctctgttcaa acgacatttt     1380

actcaggtgg aattttatca gggttccgtc ctcaatccac atgatcttgc aagagtcaag     1440

atagagtcag cagatgcatg cctgatcctt gccaacaagt actgcgctga cccggatgcg     1500

gaggatgcct cgaatatcat gagagtaatc tccataaaga actaccatcc gaagataaga     1560

atcatcactc aaatgctgca gtatcacaac aaggcccatc tgctaaacat cccgagctgg     1620

aattggaaag aaggtgatga cgcaatctgc ctcgcagagt tgaagttggg cttcatagcc     1680

cagagctgcc tggctcaagg cctctccacc atgcttgcca acctcttctc catgaggtca     1740

ttcataaaga ttgaggaaga cacatggcag aaatactact tggaaggagt ctcaaatgaa     1800

atgtacacag aatatctctc cagtgccttc gtgggtctgt ccttccctac tgtttgtgag     1860

ctgtgttttg tgaagctcaa gctcctaatg atagccattg agtacaagtc tgccaaccga     1920

gagagccgta tattaattaa tcctggaaac catcttaaga tccaagaagg tactttagga     1980

tttttcatcg caagtgatgc caaagaagtt aaaagggcat ttttttactg caaggcctgt     2040

catgatgaca tcacagatcc caaaagaata aaaaaatgtg gctgcaaacg gcttgaagat     2100

gagcagccgt caacactatc accaaaaaaa aagcaacgga atggaggcat gcggaactca     2160

cccaacacct cgcctaagct gatgaggcat gaccccttgt taattcctgg caatgatcag     2220

attgacaaca tggactccaa tgtgaagaag tacgactcta ctgggatgtt tcactggtgt     2280

gcacccaagg agatagagaa agtcatcctg gtcacaggct ggatgccgta tctgggacct     2340

agggttttaa tgacttgcct ggatattggt gtagtatgca tgccaactga tattcaatca     2400

acatctcctg ccagcataaa aaagtttaag gagactcgaa gtgaagctgc catgaccgtc     2460

ctgagtggcc atgtcgtggt ctgcatcttt ggcgacgtca gctcagccct gatcggcctc     2520

cggaacctgg tgatgccgct ccgtgccagc aactttcatt accatgagct caagcacatt     2580

gtgtttgtgg gctctattga gtacctcaag cgggaatggg agacgcttca taacttcccc     2640

aaagtgtcca tattgcctgg tacgccatta agtcgggctg atttaagggc tgtcaacatc     2700

aacctctgtg acatgtgcgt tatcctgtca gccaatcaga ataatattga tgatacttcg     2760

ctgcaggaca aggaatgcat cttggcgtca ctcaacatca aatctatgca gtttgatgac     2820

agcatcggag tcttgcaggc taattcccaa gggttcacac ctccaggaat ggatagatcc     2880

tctccagata acagcccagt gcacgggatg ttacgtcaac catccatcac aactggggtc     2940

aacatcccca tcatcactga actagtgaac gatactaatg ttcagttttt ggaccaagac     3000

gatgatgatg accctgatac agaactgtac ctcacgcagc cctttgcctg tgggacagca     3060

tttgccgtca gtgtcctgga ctcactcatg agcgcgacgt acttcaatga caatatcctc     3120

accctgatac ggaccctggt gaccggagga gccacgccgg agctggaggc tctgattgct     3180

gaggaaaacg cccttagagg tggctacagc accccgcaga cactggccaa tagggaccgc     3240

tgccgcgtgg cccagttagc tctgctcgat gggccatttg cggacttagg ggatggtggt     3300

tgttatggtg atctgttctg caaagctctg aaaacatata atatgctttg ttttggaatt     3360

taccggctga gagatgctca cctcagcacc cccagtcagt gcacaaagag gtatgtcatc     3420

accaacccgc cctatgagtt tgagctcgtg ccgacggacc tgatcttctg cttaatgcag     3480

tttgaccaca atgccggcca gtcccgggcc agcctgtccc attcctccca ctcgtcgcag     3540

tcctccagca agaagagctc ctctgttcac tccatcccat ccacagcaaa ccgacagaac     3600

cggcccaagt ccagggagtc ccgggacaaa cagaagtacg tgcaggaaga gcggctttga     3660


<210>  35
<211>  3537
<212>  DNA
<213>  Homo sapiens

<400>  35
atggcaaatg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggaggc       60

agcagtctta gaatgagtag caatatccac gcgaaccatc tcagcctaga cgcgtcctcc      120

tcctcctcct cctcctcttc ctcttcttct tcttcctcct cctcttcctc ctcgtcctcg      180

gtccacgagc ccaagatgga tgcgctcatc atcccggtga ccatggaggt gccgtgcgac      240

agccggggcc aacgcatgtg gtgggctttc ctggcctcct ccatggtgac tttcttcggg      300

ggcctcttca tcatcttgct ctggcggacg ctcaagtacc tgtggaccgt gtgctgccac      360

tgcgggggca agacgaagga ggcccagaag attaacaatg gctcaagcca ggcggatggc      420

actctcaaac cagtggatga aaaagaggag gcagtggccg ccgaggtcgg ctggatgacc      480

tccgtgaagg actgggcggg ggtgatgata tccgcccaga cactgactgg cagagtcctg      540

gttgtcttag tctttgctct cagcatcggt gcacttgtaa tatacttcat agattcatca      600

aacccaatag aatcctgcca gaatttctac aaagatttca cattacagat cgacatggct      660

ttcaacgtgt tcttccttct ctacttcggc ttgcggttta ttgcagccaa cgataaattg      720

tggttctggc tggaagtgaa ctctgtagtg gatttcttca cggtgccccc cgtgtttgtg      780

tctgtgtact taaacagaag ttggcttggt ttgagatttt taagagctct gagactgata      840

cagttttcag aaattttgca gtttctgaat attcttaaaa caagtaattc catcaagctg      900

gtgaatctgc tctccatatt tatcagcacg tggctgactg cagccgggtt catccatttg      960

gtggagaatt caggggaccc atgggaaaat ttccaaaaca accaggctct cacctactgg     1020

gaatgtgtct atttactcat ggtcacaatg tccaccgttg gttatgggga tgtttatgca     1080

aaaaccacac ttgggcgcct cttcatggtc ttcttcatcc tcgggggact ggccatgttt     1140

gccagctacg tccctgaaat catagagtta ataggaaacc gcaagaaata cgggggctcc     1200

tatagtgcgg ttagtggaag aaagcacatt gtggtctgcg gacacatcac tctggagagt     1260

gtttccaact tcctgaagga ctttctgcac aaggaccggg atgacgtcaa tgtggagatc     1320

gtttttcttc acaacatctc ccccaacctg gagcttgaag ctctgttcaa acgacatttt     1380

actcaggtgg aattttatca gggttccgtc ctcaatccac atgatcttgc aagagtcaag     1440

atagagtcag cagatgcatg cctgatcctt gccaacaagt actgcgctga cccggatgcg     1500

gaggatgcct cgaatatcat gagagtaatc tccataaaga actaccatcc gaagataaga     1560

atcatcactc aaatgctgca gtatcacaac aaggcccatc tgctaaacat cccgagctgg     1620

aattggaaag aaggtgatga cgcaatctgc ctcgcagagt tgaagttggg cttcatagcc     1680

cagagctgcc tggctcaagg cctctccacc atgcttgcca acctcttctc catgaggtca     1740

ttcataaaga ttgaggaaga cacatggcag aaatactact tggaaggagt ctcaaatgaa     1800

atgtacacag aatatctctc cagtgccttc gtgggtctgt ccttccctac tgtttgtgag     1860

ctgtgttttg tgaagctcaa gctcctaatg atagccattg agtacaagtc tgccaaccga     1920

gagagccgta tattaattaa tcctggaaac catcttaaga tccaagaagg tactttagga     1980

tttttcatcg caagtgatgc caaagaagtt aaaagggcat ttttttactg caaggcctgt     2040

catgatgaca tcacagatcc caaaagaata aaaaaatgtg gctgcaaacg gcttgaagat     2100

gagcagccgt caacactatc accaaaaaaa aagcaacgga atggaggcat gcggaactca     2160

cccaacacct cgcctaagct gatgaggcat gaccccttgt taattcctgg caatgatcag     2220

attgacaaca tggactccaa tgtgaagaag tacgactcta ctgggatgtt tcactggtgt     2280

gcacccaagg agatagagaa agtcatcctg actcgaagtg aagctgccat gaccgtcctg     2340

agtggccatg tcgtggtctg catctttggc gacgtcagct cagccctgat cggcctccgg     2400

aacctggtga tgccgctccg tgccagcaac tttcattacc atgagctcaa gcacattgtg     2460

tttgtgggct ctattgagta cctcaagcgg gaatgggaga cgcttcataa cttccccaaa     2520

gtgtccatat tgcctggtac gccattaagt cgggctgatt taagggctgt caacatcaac     2580

ctctgtgaca tgtgcgttat cctgtcagcc aatcagaata atattgatga tacttcgctg     2640

caggacaagg aatgcatctt ggcgtcactc aacatcaaat ctatgcagtt tgatgacagc     2700

atcggagtct tgcaggctaa ttcccaaggg ttcacacctc caggaatgga tagatcctct     2760

ccagataaca gcccagtgca cgggatgtta cgtcaaccat ccatcacaac tggggtcaac     2820

atccccatca tcactgaact agtgaacgat actaatgttc agtttttgga ccaagacgat     2880

gatgatgacc ctgatacaga actgtacctc acgcagccct ttgcctgtgg gacagcattt     2940

gccgtcagtg tcctggactc actcatgagc gcgacgtact tcaatgacaa tatcctcacc     3000

ctgatacgga ccctggtgac cggaggagcc acgccggagc tggaggctct gattgctgag     3060

gaaaacgccc ttagaggtgg ctacagcacc ccgcagacac tggccaatag ggaccgctgc     3120

cgcgtggccc agttagctct gctcgatggg ccatttgcgg acttagggga tggtggttgt     3180

tatggtgatc tgttctgcaa agctctgaaa acatataata tgctttgttt tggaatttac     3240

cggctgagag atgctcacct cagcaccccc agtcagtgca caaagaggta tgtcatcacc     3300

aacccgccct atgagtttga gctcgtgccg acggacctga tcttctgctt aatgcagttt     3360

gaccacaatg ccggccagtc ccgggccagc ctgtcccatt cctcccactc gtcgcagtcc     3420

tccagcaaga agagctcctc tgttcactcc atcccatcca cagcaaaccg acagaaccgg     3480

cccaagtcca gggagtcccg ggacaaacag aagtacgtgc aggaagagcg gctttga        3537


<210>  36
<211>  507
<212>  DNA
<213>  Homo sapiens

<400>  36
atggcaaatg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggaggc       60

agcagtctta gaatgagtag caatatccac gcgaaccatc tcagcctaga cgcgtcctcc      120

tcctcctcct cctcctcttc ctcttcttct tcttcctcct cctcttcctc ctcgtcctcg      180

gtccacgagc ccaagatgga tgcgctcatc atcccggtga ccatggaggt gccgtgcgac      240

agccggggcc aacgcatgtg gtgggctttc ctggcctcct ccatggtgac tttcttcggg      300

ggcctcttca tcatcttgct ctggcggacg ctcaagtacc tgtggaccgt gtgctgccac      360

tgcgggggca agacgaaggc cacccacttt gggtccccgg aaatgccacc agcagcgcgg      420

agctggagcg ggagtccgcc tgaggccgcg gttttacgcg gagcgtcttc cctggcgctc      480

gaggtggcta gatgtcgtcg gctttag                                          507


<210>  37
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  37
atggtgaaga agctggtgat ggcccagaag cggggagaga cacgagccct ttgcctgggt       60

gtaaccatgg tggtgtgtgc cgtcatcacc tactacatcc tggtcacgac tgtgctgccc      120

ctctaccaga aaagcgtgtg gacccaggaa tccaagtgcc acctgattga gaccaacatc      180

agggaccagg aggagctgaa gggcaagaag gtgccccagt acccatgcct gtgggtcaac      240

gtgtcagctg ccggcaggtg ggctgtgctg taccacacgg aggacactcg ggaccagaac      300

cagcagtgct cctacatccc aggcagcgtg gacaattacc agacggcccg ggccgacgtg      360

gagaaggtca gagccaaatt ccaagagcag caggtcttct actgcttctc cgcacctcgg      420

gggaacgaaa ccagcgtcct attccagcgc ctctacgggc cccaggccct cctcttctcc      480

ctcttctggc ccaccttcct gctgaccggt ggcctcctca ttatcgccat ggtgaagagc      540

aaccagtacc tgtccatcct ggcggcccag aagtag                                576


<210>  38
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  38
atgtttatat ggaccagtgg ccggacctct tcatcttata gacatgatga aaaaagaaat       60

atttaccaga aaatcaggga ccatgacctc ctggacaaaa ggaaaacagt cacagcactg      120

aaggcaggag aggaccgagc tattctcctg ggactggcta tgatggtgtg ctccatcatg      180

atgtattttc tgctgggaat cacactcctg cgctcataca tgcagagcgt gtggaccgaa      240

gagtctcaat gcaccttgct gaatgcgtcc atcacggaaa catttaattg ctccttcagc      300

tgtggtccag actgctggaa actttctcag tacccctgcc tccaggtgta cgttaacctg      360

acttcttccg gggaaaagct cctcctctac cacacagaag agacaataaa aatcaatcag      420

aagtgctcct atatacctaa atgtggaaaa aattttgaag aatccatgtc cctggtgaat      480

gttgtcatgg aaaacttcag gaagtatcaa cacttctcct gctattctga cccagaagga      540

aaccagaaga gtgttatcct aacaaaactc tacagttcca acgtgctgtt ccattcactc      600

ttctggccaa cctgtatgat ggctgggggt gtggcaattg ttgccatggt gaaacttaca      660

cagtacctct ccctactatg tgagaggatc caacggatca atagataa                   708


<210>  39
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  39
atggactttt caccaagctc tgaactggga tttcattttg ttgcattcat cctgctcacg       60

agacacagga cagcctttcc tgcctcaggg aagaagagag agacagacta cagtgatgga      120

gacccactag atgtgcacaa gaggctgcca tccagtgctg gagaggaccg agccgtgatg      180

ctggggtttg ccatgatggg cttctcagtc ctaatgttct tcttgctcgg aacaaccatt      240

ctaaagcctt ttatgctcag cattcagaga gaagaatcga cctgcactgc catccacaca      300

gatatcatgg acgactggct ggactgtgcc ttcacctgtg gtgtgcactg ccacggtcag      360

gggaagtacc cgtgtcttca ggtgtttgtg aacctcagcc atccaggtca gaaagctctc      420

ctacattata atgaagaggc tgtccagata aatcccaagt gcttttacac acctaagtgc      480

caccaagata gaaatgattt gctcaacagt gctctggaca taaaagaatt cttcgatcac      540

aaaaatggaa cccccttttc atgcttctac agtccagcca gccaatctga agatgtcatt      600

cttataaaaa agtatgacca aatggctatc ttccactgtt tattttggcc ttcactgact      660

ctgctaggtg gtgccctgat tgttggcatg gtgagattaa cacaacacct gtccttactg      720

tgtgaaaaat atagcactgt agtcagagat gaggtaggtg gaaaagtacc ttatatagaa      780

cagcatcagt tcaaactgtg cattatgagg aggagcaaag gaagagcaga gaaatcttaa      840


<210>  40
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  40
atgcagccct tcagcatccc cgtgcaaatc acacttcagg gcagccggag gcgccagggg       60

aggacagcct ttcctgcctc agggaagaag agagagacag actacagtga tggagaccca      120

ctagatgtgc acaagaggct gccatccagt gctggagagg accgagccgt gatgctgggg      180

tttgccatga tgggcttctc agtcctaatg ttcttcttgc tcggaacaac cattctaaag      240

ccttttatgc tcagcattca gagagaagaa tcgacctgca ctgccatcca cacagatatc      300

atggacgact ggctggactg tgccttcacc tgtggtgtgc actgccacgg tcaggggaag      360

tacccgtgtc ttcaggtgtt tgtgaacctc agccatccag gtcagaaagc tctcctacat      420

tataatgaag aggctgtcca gataaatccc aagtgctttt acacacctaa gtgccaccaa      480

gatagaaatg atttgctcaa cagtgctctg gacataaaag aattcttcga tcacaaaaat      540

ggaaccccct tttcatgctt ctacagtcca gccagccaat ctgaagatgt cattcttata      600

aaaaagtatg accaaatggc tatcttccac tgtttatttt ggccttcact gactctgcta      660

ggtggtgccc tgattgttgg catggtgaga ttaacacaac acctgtcctt actgtgtgaa      720

aaatatagca ctgtagtcag agatgaggta ggtggaaaag taccttatat agaacagcat      780

cagttcaaac tgtgcattat gaggaggagc aaaggaagag cagagaaatc ttaa            834


<210>  41
<211>  828
<212>  DNA
<213>  Homo sapiens

<400>  41
atgttccccc ttctttatga gctcactgca gtatctcctt ctccctttcc ccaaaggaca       60

gcctttcctg cctcagggaa gaagagagag acagactaca gtgatggaga cccactagat      120

gtgcacaaga ggctgccatc cagtgctgga gaggaccgag ccgtgatgct ggggtttgcc      180

atgatgggct tctcagtcct aatgttcttc ttgctcggaa caaccattct aaagcctttt      240

atgctcagca ttcagagaga agaatcgacc tgcactgcca tccacacaga tatcatggac      300

gactggctgg actgtgcctt cacctgtggt gtgcactgcc acggtcaggg gaagtacccg      360

tgtcttcagg tgtttgtgaa cctcagccat ccaggtcaga aagctctcct acattataat      420

gaagaggctg tccagataaa tcccaagtgc ttttacacac ctaagtgcca ccaagataga      480

aatgatttgc tcaacagtgc tctggacata aaagaattct tcgatcacaa aaatggaacc      540

cccttttcat gcttctacag tccagccagc caatctgaag atgtcattct tataaaaaag      600

tatgaccaaa tggctatctt ccactgttta ttttggcctt cactgactct gctaggtggt      660

gccctgattg ttggcatggt gagattaaca caacacctgt ccttactgtg tgaaaaatat      720

agcactgtag tcagagatga ggtaggtgga aaagtacctt atatagaaca gcatcagttc      780

aaactgtgca ttatgaggag gagcaaagga agagcagaga aatcttaa                   828


<210>  42
<211>  774
<212>  DNA
<213>  Homo sapiens

<400>  42
atgacagcct ttcctgcctc agggaagaag agagagacag actacagtga tggagaccca       60

ctagatgtgc acaagaggct gccatccagt gctggagagg accgagccgt gatgctgggg      120

tttgccatga tgggcttctc agtcctaatg ttcttcttgc tcggaacaac cattctaaag      180

ccttttatgc tcagcattca gagagaagaa tcgacctgca ctgccatcca cacagatatc      240

atggacgact ggctggactg tgccttcacc tgtggtgtgc actgccacgg tcaggggaag      300

tacccgtgtc ttcaggtgtt tgtgaacctc agccatccag gtcagaaagc tctcctacat      360

tataatgaag aggctgtcca gataaatccc aagtgctttt acacacctaa gtgccaccaa      420

gatagaaatg atttgctcaa cagtgctctg gacataaaag aattcttcga tcacaaaaat      480

ggaaccccct tttcatgctt ctacagtcca gccagccaat ctgaagatgt cattcttata      540

aaaaagtatg accaaatggc tatcttccac tgtttatttt ggccttcact gactctgcta      600

ggtggtgccc tgattgttgg catggtgaga ttaacacaac acctgtcctt actgtgtgaa      660

aaatatagca ctgtagtcag agatgaggta ggtggaaaag taccttatat agaacagcat      720

cagttcaaac tgtgcattat gaggaggagc aaaggaagag cagagaaatc ttaa            774


<210>  43
<211>  522
<212>  DNA
<213>  Homo sapiens

<400>  43
atgcagccct tcagcatccc cgtgcaaatc acacttcagg gcagccggag gcgccagggg       60

aggacagcct ttcctgcctc agggaagaag agagagacag actacagtga tggagaccca      120

ctagatgtgc acaagaggct gccatccagt gctggagagg accgagccgt gatgctgggg      180

tttgccatga tgggcttctc agtcctaatg ttcttcttgc tcggaacaac cattctaaag      240

ccttttatgc tcagcattca gagagaagaa tcgacctgca ctgccatcca cacagatatc      300

atggacgact ggctggactg tgccttcacc tgtggtgtgc actgccacgg tcaggggaag      360

tacccgtgtc ttcaggtgtt tgtgaacctc agccatccag gtcagaaagc tctcctacat      420

tataatgaag aggctgtcca gataaatccc aagcgtgatg ttacagactg cagagttaaa      480

gaaaagcaga cattgacagt ttctgatgag cataaacagt aa                         522


<210>  44
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  44
atggcgaagc tccgggtggc ttacgagtac acggaagccg aggacaagag catccggctc       60

ggcttgtttc tcatcatctc cggcgtcgtg tcgctcttca tcttcggctt ctgctggctg      120

agtcccgcgc tgcaggatct gcaagccacg gaggccaatt gcacggtgct gtcggtgcag      180

cagatcggcg aggtgttcga gtgcaccttc acctgtggcg ccgactgcag gggcacctcg      240

cagtacccct gcgtccaggt ctacgtgaac aactctgagt ccaactctag ggcgctgctg      300

cacagcgacg agcaccagct cctgaccaac cccaagtgct cctatatccc tccctgtaag      360

agagaaaatc agaagaattt ggaaagtgtc atgaattggc aacagtactg gaaagatgag      420

attggttccc agccatttac ttgctatttt aatcaacatc aaagaccaga tgatgtgctt      480

ctgcatcgca ctcatgatga gattgtcctc ctgcattgct tcctctggcc cctggtgaca      540

tttgtggtgg gcgttctcat tgtggtcctg accatctgtg ccaagagctt ggcggtcaag      600

gcggaagcca tgaagaagcg caagttctct taa                                   633


<210>  45
<211>  6880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVAX-hSlo1-C911A

<400>  45
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gcttcttgtt ctttttgcag aagctcagaa taaacgctca actttggcag      840

aatcgataag cttgatcgag cccctgcgcc tgccgcccat tgctagctat ggcaaacggt      900

ggcggcggcg gcggcggcag cagcggcggc ggcggcggcg gcggcggagg cagcggtctt      960

agaatgagca gcaatatcca cgcgaaccat ctcagcctag acgcgtcctc ctcctcctcc     1020

tcctcctctt cctcttcttc ttcttcctcc tcctcttcct cctcgtcctc ggtccacgag     1080

cccaagatgg atgcgctcat catcccggtg accatggagg tgccgtgcga cagccggggc     1140

caacgcatgt ggtgggcttt cctggcctcc tccatggtga ctttcttcgg gggcctcttc     1200

atcatcttgc tctggcggac gctcaagtac ctgtggaccg tgtgctgcca ctgcgggggc     1260

aagacgaagg aggcccagaa gattaacaat ggctcaagcc aggcggatgg cactctcaaa     1320

ccagtggatg aaaaagagga ggcagtggcc gccgaggtcg gctggatgac ctccgtgaag     1380

gactgggcgg gggtgatgat atccgcccag acactgactg gcagagtcct ggttgtctta     1440

gtctttgctc tcagcatcgg tgcacttgta atatacttca tagattcatc aaacccaata     1500

gaatcctgcc agaatttcta caaagatttc acattacaga tcgacatggc tttcaacgtg     1560

ttcttccttc tctactttgg cttgcggttt attgcagcca acgataaatt gtggttctgg     1620

ctggaagtga actctgtagt ggatttcttc acggtgcccc ccgtgtttgt gtctgtgtac     1680

ttaaacagaa gttggcttgg tttgagattt ttaagagctc tgagactgat acagttttca     1740

gaaattttgc agtttctgaa tattcttaaa acaagtaatt ccatcaagct ggtgaatctg     1800

ctctccatat ttatcagcac gtggctgact gcagctgggt tcatccattt ggtggagaat     1860

tcaggggacc catgggaaaa tttccaaaac aaccaggctc tcacctactg ggaatgtgtc     1920

tatttactca tggtcacaat gtccaccgtt ggttatgggg atgtttatgc aaaaaccaca     1980

cttcggcgcc tcttcatggt cttcttcatc ctcgggggac tggccatgtt tgccagctac     2040

gtccctgaaa tcatagagtt aataggaaac cgcaagaaat acgggggctc ctatagtgcg     2100

gttagtggaa gaaagcacat tgtggtctgc ggacacatca ctctggagag tgtttccaac     2160

ttcctgaagg actttctgca caaggaccgg gatgacgtca atgtggagat cgtttttctt     2220

cacaacatct cccccaacct ggagcttgaa gctctgttca aacgacattt tactcaggtg     2280

gaattttatc agggttccgt cctcaatcca catgatcttg caagagtcaa gatagagtca     2340

gcagatgcat gcctgatcct tgccaacaag tactgcgctg acccggatgc ggaggatgcc     2400

tcgaatatca tgagagtaat ctccataaag aactaccatc cgaagataag aatcatcact     2460

caaatgctgc agtatcacaa caaggcccat ctgctaaaca tcccgagctg gaattggaaa     2520

gaaggtgatg acgcaatctg cctcgcagag ttgaagttgg gcttcatagc ccagagctgc     2580

ctggctcaag gcctctccac catgcttgcc aacctcttct ccatgaggtc attcataaag     2640

attgaggaag acacatggca gaaatactac ttggaaggag tctcaaatga aatgtacaca     2700

gaatatctct ccagtgcctt cgtgggtctg tccttcccta ctgtttgtga gctgtgtttt     2760

gtgaagctca agctcctaat gatagccatt gagtacaagt ctgccaaccg agagagccgt     2820

atattaatta atcctggaaa ccatcttaag atccaagaag gtactttagg atttttcatc     2880

gcaagtgatg ccaaagaagt taaaagggca tttttttact gcaaggcctg tcatgatgac     2940

atcacagatc ccaaaagaat aaaaaaatgt ggctgcaaac ggcttgaaga tgagcagccg     3000

tcaacactat caccaaaaaa aaagcaacgg aatggaggca tgcggaactc acccaacacc     3060

tcgcctaagc tgatgaggca tgaccccttg ttaattcctg gcaatgatca gattgacaac     3120

atggactcca atgtgaagaa gtacgactct actgggatgt ttcactggtg tgcacccaag     3180

gagatagaga aagtcatcct gactcgaagt gaagctgcca tgaccgtcct gagtggccat     3240

gtcgtggtct gcatctttgg cgacgtcagc tcagccctga tcggcctccg gaacctggtg     3300

atgccgctcc gtgccagcaa ctttcattac catgagctca agcacattgt gtttgtgggc     3360

tctattgagt acctcaagcg ggaatgggag acgcttcata acttccccaa agtgtccata     3420

ttgcctggta cgccattaag tcgggctgat ttaagggctg tcaacatcaa cctctgtgac     3480

atgtgcgtta tcctgtcagc caatcagaat aatattgatg atacttcgct gcaggacaag     3540

gaatgcatct tggcgtcact caacatcaaa tctatgcagt ttgatgacag catcggagtc     3600

ttgcaggcta attcccaagg gttcacacct ccaggaatgg atagatcctc tccagataac     3660

agcccagtgc acgggatgtt acgtcaacca tccatcacaa ctggggtcaa catccccatc     3720

atcactgaac tagtgaacga tactaatgtt cagtttttgg accaagacga tgatgatgac     3780

cctgatacag aactgtacct cacgcagccc tttgccgctg ggacagcatt tgccgtcagt     3840

gtcctggact cactcatgag cgcgacgtac ttcaatgaca atatcctcac cctgatacgg     3900

accctggtga ccggaggagc cacgccggag ctggaggctc tgattgctga ggaaaacgcc     3960

cttagaggtg gctacagcac cccgcagaca ctggccaata gggaccgctg ccgcgtggcc     4020

cagttagctc tgctcgatgg gccatttgcg gacttagggg atggtggttg ttatggtgat     4080

ctgttctgca aagctctgaa aacatataat atgctttgtt ttggaattta ccggctgaga     4140

gatgctcacc tcagcacccc cagtcagtgc acaaagaggt atgtcatcac caacccgccc     4200

tatgagtttg agctcgtgcc gacggacctg atcttctgct taatgcagtt tgaccacaat     4260

gccggccagt cccgggccag cctgtcccat tcctcccact cgtcgcagtc ctccagcaag     4320

aagagctcct ctgttcactc catcccatcc acagcaaacc gacagaaccg gcccaagtcc     4380

agggagtccc gggacaaaca gaagtacgtg caggaagagc ggctttgata tgtgtatcca     4440

ccgccactgt gtgaaactgt atctgccact catttcccca gttggtgttt ccaacaaagt     4500

aactttccct gttttcccct gtagtccccc cccttttttt ttacacatat ttgcatatgt     4560

atgatagtgt gcatgtggtt gtcattttta tttcaccacc ataaaaccct tgagcacaac     4620

agcaaataag cagacgggct ccggaattct gcagcccggg ggatccacta gttctagagg     4680

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     4740

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     4800

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     4860

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     4920

ggtgggctct atggcttcta ctgggcggtt ttatggacag caagcgaacc ggaattgcca     4980

gctggggcgc cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttctcg     5040

ccgccaagga tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg     5100

tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg     5160

ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg     5220

ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat     5280

gaactgcaag acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca     5340

gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg     5400

gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat     5460

gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa     5520

catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg     5580

gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg     5640

cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg     5700

gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat     5760

caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac     5820

cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc     5880

cttcttgacg agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc     5940

cttacgcatc tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc     6000

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     6060

aataaccctg ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa     6120

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     6180

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     6240

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     6300

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     6360

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     6420

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     6480

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     6540

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     6600

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     6660

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     6720

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     6780

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     6840

ggttcctggc cttttgctgg ccttttgctc acatgttctt                           6880


<210>  46
<211>  6591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVAX-hSlo1-deltaNX

<400>  46
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gaccaccatg gatgcgctca tcatcccggt gaccatggag gtgccgtgcg      840

acagccgggg ccaacgcatg tggtgggctt tcctggcctc ctccatggtg actttcttcg      900

ggggcctctt catcatcttg ctctggcgga cgctcaagta cctgtggacc gtgtgctgcc      960

actgcggggg caagacgaag gaggcccaga agattaacaa tggctcaagc caggcggatg     1020

gcactctcaa accagtggat gaaaaagagg aggcagtggc cgccgaggtc ggctggatga     1080

cctccgtgaa ggactgggcg ggggtgatga tatccgccca gacactgact ggcagagtcc     1140

tggttgtctt agtctttgct ctcagcatcg gtgcacttgt aatatacttc atagattcat     1200

caaacccaat agaatcctgc cagaatttct acaaagattt cacattacag atcgacatgg     1260

ctttcaacgt gttcttcctt ctctactttg gcttgcggtt tattgcagcc aacgataaat     1320

tgtggttctg gctggaagtg aactctgtag tggatttctt cacggtgccc cccgtgtttg     1380

tgtctgtgta cttaaacaga agttggcttg gtttgagatt tttaagagct ctgagactga     1440

tacagttttc agaaattttg cagtttctga atattcttaa aacaagtaat tccatcaagc     1500

tggtgaatct gctctccata tttatcagca cgtggctgac tgcagctggg ttcatccatt     1560

tggtggagaa ttcaggggac ccatgggaaa atttccaaaa caaccaggct ctcacctact     1620

gggaatgtgt ctatttactc atggtcacaa tgtccaccgt tggttatggg gatgtttatg     1680

caaaaaccac acttcggcgc ctcttcatgg tcttcttcat cctcggggga ctggccatgt     1740

ttgccagcta cgtccctgaa atcatagagt taataggaaa ccgcaagaaa tacgggggct     1800

cctatagtgc ggttagtgga agaaagcaca ttgtggtctg cggacacatc actctggaga     1860

gtgtttccaa cttcctgaag gactttctgc acaaggaccg ggatgacgtc aatgtggaga     1920

tcgtttttct tcacaacatc tcccccaacc tggagcttga agctctgttc aaacgacatt     1980

ttactcaggt ggaattttat cagggttccg tcctcaatcc acatgatctt gcaagagtca     2040

agatagagtc agcagatgca tgcctgatcc ttgccaacaa gtactgcgct gacccggatg     2100

cggaggatgc ctcgaatatc atgagagtaa tctccataaa gaactaccat ccgaagataa     2160

gaatcatcac tcaaatgctg cagtatcaca acaaggccca tctgctaaac atcccgagct     2220

ggaattggaa agaaggtgat gacgcaatct gcctcgcaga gttgaagttg ggcttcatag     2280

cccagagctg cctggctcaa ggcctctcca ccatgcttgc caacctcttc tccatgaggt     2340

cattcataaa gattgaggaa gacacatggc agaaatacta cttggaagga gtctcaaatg     2400

aaatgtacac agaatatctc tccagtgcct tcgtgggtct gtccttccct actgtttgtg     2460

agctgtgttt tgtgaagctc aagctcctaa tgatagccat tgagtacaag tctgccaacc     2520

gagagagccg tatattaatt aatcctggaa accatcttaa gatccaagaa ggtactttag     2580

gatttttcat cgcaagtgat gccaaagaag ttaaaagggc atttttttac tgcaaggcct     2640

gtcatgatga catcacagat cccaaaagaa taaaaaaatg tggctgcaaa cggcttgaag     2700

atgagcagcc gtcaacacta tcaccaaaaa aaaagcaacg gaatggaggc atgcggaact     2760

cacccaacac ctcgcctaag ctgatgaggc atgacccctt gttaattcct ggcaatgatc     2820

agattgacaa catggactcc aatgtgaaga agtacgactc tactgggatg tttcactggt     2880

gtgcacccaa ggagatagag aaagtcatcc tgactcgaag tgaagctgcc atgaccgtcc     2940

tgagtggcca tgtcgtggtc tgcatctttg gcgacgtcag ctcagccctg atcggcctcc     3000

ggaacctggt gatgccgctc cgtgccagca actttcatta ccatgagctc aagcacattg     3060

tgtttgtggg ctctattgag tacctcaagc gggaatggga gacgcttcat aacttcccca     3120

aagtgtccat attgcctggt acgccattaa gtcgggctga tttaagggct gtcaacatca     3180

acctctgtga catgtgcgtt atcctgtcag ccaatcagaa taatattgat gatacttcgc     3240

tgcaggacaa ggaatgcatc ttggcgtcac tcaacatcaa atctatgcag tttgatgaca     3300

gcatcggagt cttgcaggct aattcccaag ggttcacacc tccaggaatg gatagatcct     3360

ctccagataa cagcccagtg cacgggatgt tacgtcaacc atccatcaca actggggtca     3420

acatccccat catcactgaa ctagtgaacg atactaatgt tcagtttttg gaccaagacg     3480

atgatgatga ccctgataca gaactgtacc tcacgcagcc ctttgcctgt gggacagcat     3540

ttgccgtcag tgtcctggac tcactcatga gcgcgacgta cttcaatgac aatatcctca     3600

ccctgatacg gaccctggtg accggaggag ccacgccgga gctggaggct ctgattgctg     3660

aggaaaacgc ccttagaggt ggctacagca ccccgcagac actggccaat agggaccgct     3720

gccgcgtggc ccagttagct ctgctcgatg ggccatttgc ggacttaggg gatggtggtt     3780

gttatggtga tctgttctgc aaagctctga aaacatataa tatgctttgt tttggaattt     3840

accggctgag agatgctcac ctcagcaccc ccagtcagtg cacaaagagg tatgtcatca     3900

ccaacccgcc ctatgagttt gagctcgtgc cgacggacct gatcttctgc ttaatgcagt     3960

ttgaccacaa tgccggccag tcccgggcca gcctgtccca ttcctcccac tcgtcgcagt     4020

cctccagcaa gaagagctcc tctgttcact ccatcccatc cacagcaaac cgacagaacc     4080

ggcccaagtc cagggagtcc cgggacaaac agaagtacgt gcaggaagag cggctttgat     4140

atgtgtatcc accgccactg tgtgaaactg tatctgccac tcatttcccc agttggtgtt     4200

tccaacaaag taactttccc tgttttcccc tgtagtcccc cccctttttt tttacacata     4260

tttgcatatg tatgatagtg tgcatgtggt tgtcattttt atttcaccac cataaaaccc     4320

ttgagcacaa cagcaaataa gcagacgggc tccggaattc tgcagcccgg gggatccact     4380

agttctagag ggcccgttta aacccgctga tcagcctcga ctgtgccttc tagttgccag     4440

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact     4500

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt     4560

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat     4620

gctggggatg cggtgggctc tatggcttct actgggcggt tttatggaca gcaagcgaac     4680

cggaattgcc agctggggcg ccctctggta aggttgggaa gccctgcaaa gtaaactgga     4740

tggctttctc gccgccaagg atctgatggc gcaggggatc aagctctgat caagagacag     4800

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt     4860

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg     4920

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg     4980

gtgccctgaa tgaactgcaa gacgaggcag cgcggctatc gtggctggcc acgacgggcg     5040

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg     5100

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca     5160

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc     5220

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc     5280

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca     5340

aggcgagcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga     5400

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg     5460

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg     5520

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg     5580

ccttctatcg ccttcttgac gagttcttct gaattattaa cgcttacaat ttcctgatgc     5640

ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacaggtg gcacttttcg     5700

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc     5760

gctcatgaga caataaccct gataaatgct tcaataatag cacgtgctaa aacttcattt     5820

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     5880

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     5940

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     6000

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     6060

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     6120

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     6180

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     6240

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     6300

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     6360

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     6420

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     6480

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     6540

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct t              6591


<210>  47
<211>  1113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hSlo encoded by deltaNX

<400>  47

Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp Ser 
1               5                   10                  15      


Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val Thr 
            20                  25                  30          


Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys Tyr 
        35                  40                  45              


Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala Gln 
    50                  55                  60                  


Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro Val 
65                  70                  75                  80  


Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr Ser 
                85                  90                  95      


Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr Gly 
            100                 105                 110         


Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu Val 
        115                 120                 125             


Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn Phe 
    130                 135                 140                 


Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe Phe 
145                 150                 155                 160 


Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu Trp 
                165                 170                 175     


Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro Pro 
            180                 185                 190         


Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg Phe 
        195                 200                 205             


Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe Leu 
    210                 215                 220                 


Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu Ser 
225                 230                 235                 240 


Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu Val 
                245                 250                 255     


Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala Leu 
            260                 265                 270         


Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr Val 
        275                 280                 285             


Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Arg Arg Leu Phe Met 
    290                 295                 300                 


Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val Pro 
305                 310                 315                 320 


Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser Tyr 
                325                 330                 335     


Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile Thr 
            340                 345                 350         


Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp Arg 
        355                 360                 365             


Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro Asn 
    370                 375                 380                 


Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu Phe 
385                 390                 395                 400 


Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys Ile 
                405                 410                 415     


Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala Asp 
            420                 425                 430         


Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile Lys 
        435                 440                 445             


Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr His 
    450                 455                 460                 


Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu Gly 
465                 470                 475                 480 


Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala Gln 
                485                 490                 495     


Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe Ser 
            500                 505                 510         


Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr Tyr 
        515                 520                 525             


Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser Ala 
    530                 535                 540                 


Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val Lys 
545                 550                 555                 560 


Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg Glu 
                565                 570                 575     


Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu Gly 
            580                 585                 590         


Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg Ala 
        595                 600                 605             


Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys Arg 
    610                 615                 620                 


Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser Thr 
625                 630                 635                 640 


Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro 
                645                 650                 655     


Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly 
            660                 665                 670         


Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser 
        675                 680                 685             


Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile 
    690                 695                 700                 


Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val Val 
705                 710                 715                 720 


Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn 
                725                 730                 735     


Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys 
            740                 745                 750         


His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu 
        755                 760                 765             


Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu 
    770                 775                 780                 


Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys 
785                 790                 795                 800 


Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln 
                805                 810                 815     


Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe 
            820                 825                 830         


Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro 
        835                 840                 845             


Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly Met 
    850                 855                 860                 


Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile Ile Thr 
865                 870                 875                 880 


Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp Asp 
                885                 890                 895     


Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala Cys Gly 
            900                 905                 910         


Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala Thr Tyr 
        915                 920                 925             


Phe Asn Asp Asn Ile Leu Thr Leu Ile Arg Thr Leu Val Thr Gly Gly 
    930                 935                 940                 


Ala Thr Pro Glu Leu Glu Ala Leu Ile Ala Glu Glu Asn Ala Leu Arg 
945                 950                 955                 960 


Gly Gly Tyr Ser Thr Pro Gln Thr Leu Ala Asn Arg Asp Arg Cys Arg 
                965                 970                 975     


Val Ala Gln Leu Ala Leu Leu Asp Gly Pro Phe Ala Asp Leu Gly Asp 
            980                 985                 990         


Gly Gly Cys Tyr Gly Asp Leu Phe  Cys Lys Ala Leu Lys  Thr Tyr Asn 
        995                 1000                 1005             


Met Leu  Cys Phe Gly Ile Tyr  Arg Leu Arg Asp Ala  His Leu Ser 
    1010                 1015                 1020             


Thr Pro  Ser Gln Cys Thr Lys  Arg Tyr Val Ile Thr  Asn Pro Pro 
    1025                 1030                 1035             


Tyr Glu  Phe Glu Leu Val Pro  Thr Asp Leu Ile Phe  Cys Leu Met 
    1040                 1045                 1050             


Gln Phe  Asp His Asn Ala Gly  Gln Ser Arg Ala Ser  Leu Ser His 
    1055                 1060                 1065             


Ser Ser  His Ser Ser Gln Ser  Ser Ser Lys Lys Ser  Ser Ser Val 
    1070                 1075                 1080             


His Ser  Ile Pro Ser Thr Ala  Asn Arg Gln Asn Arg  Pro Lys Ser 
    1085                 1090                 1095             


Arg Glu  Ser Arg Asp Lys Gln  Lys Tyr Val Gln Glu  Glu Arg Leu 
    1100                 1105                 1110             


<210>  48
<211>  11730
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSMAA-hSlo

<400>  48
acatgtgcac agttcagaag cactcccaga atccatccaa aatatctcta tcgtgaatgg       60

aatcagaacc ttggcttgca ggaggaaagt acagaaatgt aaagtcactg actgtccatc      120

aaagccaacg atctgatgcc tttgaagaat gatagggtca cttgaggtca cttgatctct      180

gtttctgtcc agtgggctca tagtcatgga ggagagtgag caggcttcat ttcaacattt      240

caaatttctt ttacaaagtt tttttttttt atttttttat gacagggtga ctggtgatct      300

ctgtgggcaa aggatggtcc ttaatcatgc tgttaagggt cagtaaaaag ccagcaacat      360

gcggaatgtt aagggttaaa gcagttacag tgattctgac ttctaagtta ctctttgggc      420

aacacaggct ggttaatcct cactacatac ttcagttcct ggtttcatta ctacaacaca      480

aagacacaat gtataagtac aatgtagctt ccataaaaac atgactcctc tgcatattta      540

tgggtgactc gaagcatctt ttgatctagg ctaccttttg caacagtgtt gcttaaaaat      600

cgcagctagt cagagacagg cccttcctta tccaagtcct cagctaatgg cccaaaagac      660

tagccagaca ggggctggca tcttctgagg aatgtgcaaa ccgtgcctgc gtctgtccca      720

tgacactagc ccagtgtctg ggcatttgag cagttgttct gagggcttag gatgtttatc      780

cccataagca gctgagctgc ctcctgtttc gggagcagaa cagaggaatg cagtggaaga      840

gacccaggcc tctggccacc cagattagag agttttgtgc tgaggtccct atatggttgt      900

gttagagtga acggccagct tcagcccgtc tttgctcctt gtttgggaag cgagtgggag      960

gggatcagag caaggggcta tataaccctt cagcgttcag cctcccggga caccacccac     1020

ccagagtgga gaagcccagc cagtcgctgt cagggtaagt agccccagcc cagggatatg     1080

acttcgagtt ttcccaggct cttttatcat ccaatgtagc cagacattgt ctgtgggaat     1140

ctgaatgact cacgtgtttt gaatttttga ataaagattt atactgttaa aatgattgta     1200

gctttttagc ttgcatgatt ttacatccga atagggctga tttactggaa acaacgcttg     1260

atttactgga aaaggaaatg gatagaaaat taaagtttgt tcatgtgtgt catctgcaaa     1320

acctgtttac actaaaccaa ctgctctgat cccgcagcgt actgtagggg tggagtctag     1380

ctgtatgtgg taaattatac gtttgtttct acttaggcaa aagttggaaa cttttggatg     1440

tatcatgatg tagcatgagg tatttagtgc agctgaggta actggaagtg aatatcagga     1500

atgaactgag gtagttgcct gctctctgat gttggctgag tggacgcatt gcttctgggt     1560

ttccggggct ctaagagctg gtgtcctatg ctggaaatgt gtatcttgtg agtgtgttgg     1620

tgcccttaca agtcagacct atgccattgg tcatttgcag catagcatag cttttctact     1680

ttctgcaaag aaaggaggaa gtgtctcatc caggggagat ctgatttgca tttctctgcc     1740

tcacgtgtcc ctcagccgct aagtatctgt ggaaccagcc ttgccacccc acattgtaac     1800

tcagggctcg gtagcttcat cagggaatgg agttttctcg ataagatttt cctcctgttt     1860

tgtgattcat gactaaatat ggtttgcatt tgagactcat aagctgggaa gggtactgtc     1920

ctttcctccc ctcccccctc cccccaacaa ttcatttttg gcaccagatg agctccactg     1980

ggctgcacca aactccccgc cccggtgcag ttccaaaagc agaggctgga gcccagtgtg     2040

ttttacctaa ttaggaaatg ctccccgctt caaaccgagc tgctcattca ggttagataa     2100

gagttgcaaa ccacagcggc tgcgtcctct ggaaacacac agacttcttc tccagtgaca     2160

acgctccttt cagagcttaa taagacaatt ttttcctgga tatttttgat gaaatagaaa     2220

tacatcttta cggaatttga cagtattttt tcctgcattt ttttaaaaac caggtagctt     2280

atttttctga atatactaag gcacaacctt aagccatcct gcccaacaaa aagttaatat     2340

gagggttatc cttccccatt ttcagagggt atcctagttc caagtggctt atcccattgt     2400

cggggggggt actaagtatg gaaaacaggc ttagtggaca cacagactct gtgttggtcc     2460

tttggggttt cggcatatac cagtcacctg gattctgtgc ctcctggtgg tgtgaacctt     2520

tcttctgagt ccttatcatg cactggaaag gaagtaagca taaatcagag gcatagtgga     2580

aagaggaaag atcaagtgct gaagaaaccc attttcccat tcttgcaagg ggaacacatt     2640

gaagatttca ctatgatttt ggggacagag gttgaaagaa aaccaagatc gcaaacagaa     2700

tctttgggta ggaataatag ttacttgatg atatccacgc acaatgcttg ttcaacacta     2760

tggatgtcca tgggagctct caaaaatcca agcttaaatg tcaattcctt aaattgttgt     2820

taaaaacaac cctaaggggt atatactcag ttaatcaagc ttagaagaag ataccagagc     2880

tcagggaaga aaaaaagtct acaaaagctg atgcttgcca cttcaaaaga atcctagtaa     2940

acattttgga cagaataagt aagctttggg ggtagaggaa caactcacat tttattaagg     3000

tcatattctg tctctttctg taacttatca gtcttaaaca agaatagctc tcagcaacct     3060

gttgggtttt cagcttaaca gtgactttaa taaatgaaga aatgttataa ctcgtaaaat     3120

ttcaaacacc atatttggaa atttctatcc aagtttccat attagaccag ctccttaact     3180

tgtgatcctc ctgcctcagc ctcccaagtg ctaggatcat aggtgtacat catcacaccc     3240

agccttgatt catatttaat acctcaccgg ctcacaagtc tttagagcca aaagttttct     3300

cttttaaaca tttaatatga gtaaacattt taacattttc aaattctcac atgctgccca     3360

ttccttgaaa atctaccttt ggtggggggg ggggggggac tatatatata tatgtcccta     3420

tagaactctg ctctctacac tgcatctctc atctgtgctc tatgatctat tcacacacta     3480

atgctctgac cagcttgaga gtgttaatag agcgagtgac actcccgcta ttggtgctga     3540

ggacttgtgg tgttaacctg gaagtcaggg tttcggatca tcaaagtctt tacagcatag     3600

tgaaagcatt tcaagataaa gggtgttagt tgagaactgt ggagagcctc cagctaaaat     3660

aacccaacag gtccaagaac cctgtctgtg ggtggagtga ataggctata gccaaaagct     3720

atgcgttaca gtagcatttc gctcgaagtc tctgcagaac cctgaggcgc tggatcctct     3780

agtccagtgg ggtggaattc tgcagatatc cagcacagtg gcggccgctc gagcttcttg     3840

ttctttttgc agaagctcag aataaacgct caactttggc agaatcgata agcttgatcg     3900

agcccctgcg cctgccgccc attgctagct atggcaaacg gtggcggcgg cggcggcggc     3960

agcagcggcg gcggcggcgg cggcggcgga ggcagcggtc ttagaatgag cagcaatatc     4020

cacgcgaacc atctcagcct agacgcgtcc tcctcctcct cctcctcctc ttcctcttct     4080

tcttcttcct cctcctcttc ctcctcgtcc cggtccacga gcccaagatg gatgcgctca     4140

tcatcccggt gaccatggag gtgccgtgcg acagccgggg ccaacgcatg tggtgggctt     4200

tcctggcctc ctccatggtg actttcttcg ggggcctctt catcatcttg ctctggcgga     4260

cgctcaagta cctgtggacc gtgtgctgcc actgcggggg caagacgaag gaggcccaga     4320

agattaacaa tggctcaagc caggcggatg gcactctcaa accagtggat gaaaaagagg     4380

aggcagtggc cgccgaggtc ggctggatga cctccgtgaa ggactgggcg ggggtgatga     4440

tatccgccca gacactgact ggcagagtcc tggttgtctt agtctttgct ctcagcatcg     4500

gtgcacttgt aatatacttc atagattcat caaacccaat agaatcctgc cagaatttct     4560

acaaagattt cacattacag atcgacatgg ctttcaacgt gttcttcctt ctctactttg     4620

gcttgcggtt tattgcagcc aacgataaat tgtggttctg gctggaagtg aactctgtag     4680

tggatttctt cacggtgccc cccgtgtttg tgtctgtgta cttaaacaga agttggcttg     4740

gtttgagatt tttaagagct ctgagactga tacagttttc agaaattttg cagtttctga     4800

atattcttaa aacaagtaat tccatcaagc tggtgaatct gctctccata tttatcagca     4860

cgtggctgac tgcagctggg ttcatccatt tggtggagaa ttcaggggac ccatgggaaa     4920

atttccaaaa caaccaggct ctcacctact gggaatgtgt ctatttactc atggtcacaa     4980

tgtccaccgt tggttatggg gatgtttatg caaaaaccac acttgggcgc ctcttcatgg     5040

tcttcttcat cctcggggga ctggccatgt ttgccagcta cgtccctgaa atcatagagt     5100

taataggaaa ccgcaagaaa tacgggggct cctatagtgc ggttagtgga agaaagcaca     5160

ttgtggtctg cggacacatc actctggaga gtgtttccaa cttcctgaag gactttctgc     5220

acaaggaccg ggatgacgtc aatgtggaga tcgtttttct tcacaacatc tcccccaacc     5280

tggagcttga agctctgttc aaacgacatt ttactcaggt ggaattttat cagggttccg     5340

tcctcaatcc acatgatctt gcaagagtca agatagagtc agcagatgca tgcctgatcc     5400

ttgccaacaa gtactgcgct gacccggatg cggaggatgc ctcgaatatc atgagagtaa     5460

tctccataaa gaactaccat ccgaagataa gaatcatcac tcaaatgctg cagtatcaca     5520

acaaggccca tctgctaaac atcccgagct ggaattggaa agaaggtgat gacgcaatct     5580

gcctcgcaga gttgaagttg ggcttcatag cccagagctg cctggctcaa ggcctctcca     5640

ccatgcttgc caacctcttc tccatgaggt cattcataaa gattgaggaa gacacatggc     5700

agaaatacta cttggaagga gtctcaaatg aaatgtacac agaatatctc tccagtgcct     5760

tcgtgggtct gtccttccct actgtttgtg agctgtgttt tgtgaagctc aagctcctaa     5820

tgatagccat tgagtacaag tctgccaacc gagagagccg tatattaatt aatcctggaa     5880

accatcttaa gatccaagaa ggtactttag gatttttcat cgcaagtgat gccaaagaag     5940

ttaaaagggc atttttttac tgcaaggcct gtcatgatga catcacagat cccaaaagaa     6000

taaaaaaatg tggctgcaaa cggcttgaag atgagcagcc gtcaacacta tcaccaaaaa     6060

aaaagcaacg gaatggaggc atgcggaact cacccaacac ctcgcctaag ctgatgaggc     6120

atgacccctt gttaattcct ggcaatgatc agattgacaa catggactcc aatgtgaaga     6180

agtacgactc tactgggatg tttcactggt gtgcacccaa ggagatagag aaagtcatcc     6240

tgactcgaag tgaagctgcc atgaccgtcc tgagtggcca tgtcgtggtc tgcatctttg     6300

gcgacgtcag ctcagccctg atcggcctcc ggaacctggt gatgccgctc cgtgccagca     6360

actttcatta ccatgagctc aagcacattg tgtttgtggg ctctattgag tacctcaagc     6420

gggaatggga gacgcttcat aacttcccca aagtgtccat attgcctggt acgccattaa     6480

gtcgggctga tttaagggct gtcaacatca acctctgtga catgtgcgtt atcctgtcag     6540

ccaatcagaa taatattgat gatacttcgc tgcaggacaa ggaatgcatc ttggcgtcac     6600

tcaacatcaa atctatgcag tttgatgaca gcatcggagt cttgcaggct aattcccaag     6660

ggttcacacc tccaggaatg gatagatcct ctccagataa cagcccagtg cacgggatgt     6720

tacgtcaacc atccatcaca actggggtca acatccccat catcactgaa ctagtgaacg     6780

atactaatgt tcagtttttg gaccaagacg atgatgatga ccctgataca gaactgtacc     6840

tcacgcagcc ctttgcctgt gggacagcat ttgccgtcag tgtcctggac tcactcatga     6900

gcgcgacgta cttcaatgac aatatcctca ccctgatacg gaccctggtg accggaggag     6960

ccacgccgga gctggaggct ctgattgctg aggaaaacgc ccttagaggt ggctacagca     7020

ccccgcagac actggccaat agggaccgct gccgcgtggc ccagttagct ctgctcgatg     7080

ggccatttgc ggacttaggg gatggtggtt gttatggtga tctgttctgc aaagctctga     7140

aaacatataa tatgctttgt tttggaattt accggctgag agatgcgcac ctcagcaccc     7200

ccagtcagtg cacaaagagg tatgtcatca ccaacccgcc ctatgagttt gagctcgtgc     7260

cgacggacct gatcttctgc ttaatgcagt ttgaccacaa tgccggccag tcccgggcca     7320

gcctgtccca ttcctcccac tcgtcgcagt cctccagcaa gaagagctcc tctgttcact     7380

ccatcccatc cacagcaaac cgacagaacc ggcccaagtc cagggagtcc cgggacaaac     7440

agaagtacgt gcaggaagag cggctttgat atgtgtatcc accgccactg tgtgaaactg     7500

tatctgccac tcatttcccc agttggtgtt tccaacaaag taactttccc tgttttcccc     7560

tgtagtcccc cccctttttt tttacacata tttgcatatg tatgatagtg tgcatgtggt     7620

tgtcattttt atttcaccac cataaaaccc ttgagcacaa cagcaaataa gcagacgggc     7680

tccggaattc tgcagtcgac ggtaccgcgg gcccgggatc caccggtcgc caccatggtg     7740

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     7800

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     7860

ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     7920

accaccctga cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac     7980

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     8040

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     8100

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     8160

gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc     8220

aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac     8280

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     8340

agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     8400

gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaaagcggc     8460

cgcgactcta gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa     8520

acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact     8580

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata     8640

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttaag     8700

gcgtaaattg taagcgttaa tattttgtta aaattcgcgt taaatttttg ttaaatcagc     8760

tcatttttta accaataggc cgaaatcggc aaaatccctt ataaatcaaa agaatagacc     8820

gagatagggt tgagtgttgt tccagtttgg aacaagagtc cactattaaa gaacgtggac     8880

tccaacgtca aagggcgaaa aaccgtctat cagggcgatg gcccactacg tgaaccatca     8940

ccctaatcaa gttttttggg gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg     9000

agcccccgat ttagagcttg acggggaaag ccggcgaacg tggcgagaaa ggaagggaag     9060

aaagcgaaag gagcgggcgc tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc     9120

accacacccg ccgcgcttaa tgcgccgcta cagggcgcgt caggtggcac ttttcgggga     9180

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     9240

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tcctgaggcg     9300

gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag     9360

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt ggaaagtccc     9420

caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag     9480

tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc     9540

cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc     9600

tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa gatcgatcaa     9660

gagacaggat gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg     9720

gccgcttggg tggagaggct attcggctat gactgggcac aacagacaat cggctgctct     9780

gatgccgccg tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac     9840

ctgtccggtg ccctgaatga actgcaagac gaggcagcgc ggctatcgtg gctggccacg     9900

acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg     9960

ctattgggcg aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa    10020

gtatccatca tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca    10080

ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt    10140

gtcgatcagg atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc    10200

aggctcaagg cgagcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc    10260

ttgccgaata tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg    10320

ggtgtggcgg accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt    10380

ggcggcgaat gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag    10440

cgcatcgcct tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa    10500

tgaccgacca agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct    10560

atgaaaggtt gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg    10620

gggatctcat gctggagttc ttcgcccacc ctagggggag gctaactgaa acacggaagg    10680

agacaatacc ggaaggaacc cgcgctatga cggcaataaa aagacagaat aaaacgcacg    10740

gtgttgggtc gtttgttcat aaacgcgggg ttcggtccca gggctggcac tctgtcgata    10800

ccccaccgag accccattgg ggccaatacg cccgcgtttc ttccttttcc ccaccccacc    10860

ccccaagttc gggtgaaggc ccagggctcg cagccaacgt cggggcggca ggccctgcca    10920

tagcctcagg ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa    10980

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt    11040

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt    11100

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt    11160

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga    11220

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag    11280

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata    11340

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg    11400

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga    11460

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca    11520

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa    11580

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt    11640

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac    11700

ggttcctggc cttttgctgg ccttttgctc                                     11730


<210>  49
<211>  6880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVax-hSlo Variant 1

<400>  49
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gcttcttgtt ctttttgcag aagctcagaa taaacgctca actttggcag      840

aatcgataag cttgatcgag cccctgcgcc tgccgcccat tgctagctat ggcaaacggt      900

ggcggcggcg gcggcggcag cagcggcggc ggcggcggcg gcggcggagg cagcagtctt      960

agaatgagta gcaatatcca cgcgaaccat ctcagcctag acgcgtcctc ctcctcctcc     1020

tcctcctctt cctcttcttc ttcttcctcc tcctcttcct cctcgtcctc ggtccacgag     1080

cccaagatgg atgcgctcat catcccggtg accatggagg tgccgtgcga cagccggggc     1140

caacgcatgt ggtgggcttt cctggcctcc tccatggtga ctttcttcgg gggcctcttc     1200

atcatcttgc tctggcggac gctcaagtac ctgtggaccg tgtgctgcca ctgcgggggc     1260

aagacgaagg aggcccagaa gattaacaat ggctcaagcc aggcggatgg cactctcaaa     1320

ccagtggatg aaaaagagga ggcagtggcc gccgaggtcg gctggatgac ctccgtgaag     1380

gactgggcgg gggtgatgat atccgcccag acactgactg gcagagtcct ggttgtctta     1440

gtctttgctc tcagcatcgg tgcacttgta atatacttca tagattcatc aaacccaata     1500

gaatcctgcc agaatttcta caaagatttc acattacaga tcgacatggc tttcaacgtg     1560

ttcttccttc tctacttcgg cttgcggttt attgcagcca acgataaatt gtggttctgg     1620

ctggaagtga actctgtagt ggatttcttc acggtgcccc ccgtgtttgt gtctgtgtac     1680

ttaaacagaa gttggcttgg tttgagattt ttaagagctc tgagactgat acagttttca     1740

gaaattttgc agtttctgaa tattcttaaa acaagtaatt ccatcaagct ggtgaatctg     1800

ctctccatat ttatcagcac gtggctgact gcagccgggt tcatccattt ggtggagaat     1860

tcaggggacc catgggaaaa tttccaaaac aaccaggctc tcacctactg ggaatgtgtc     1920

tatttactca tggtcacaat gtccaccgtt ggttatgggg atgtttatgc aaaaaccaca     1980

cttgggcgcc tcttcatggt cttcttcatc ctcgggggac tggccatgtt tgccagctac     2040

gtccctgaaa tcatagagtt aataggaaac cgcaagaaat acgggggctc ctatagtgcg     2100

gttagtggaa gaaagcacat tgtggtctgc ggacacatca ctctggagag tgtttccaac     2160

ttcctgaagg actttctgca caaggaccgg gatgacgtca atgtggagat cgtttttctt     2220

cacaacatct cccccaacct ggagcttgaa gctctgttca aacgacattt tactcaggtg     2280

gaattttatc agggttccgt cctcaatcca catgatcttg caagagtcaa gatagagtca     2340

gcagatgcat gcctgatcct tgccaacaag tactgcgctg acccggatgc ggaggatgcc     2400

tcgaatatca tgagagtaat ctccataaag aactaccatc cgaagataag aatcatcact     2460

caaatgctgc agtatcacaa caaggcccat ctgctaaaca tcccgagctg gaattggaaa     2520

gaaggtgatg acgcaatctg cctcgcagag ttgaagttgg gcttcatagc ccagagctgc     2580

ctggctcaag gcctctccac catgcttgcc aacctcttct ccatgaggtc attcataaag     2640

attgaggaag acacatggca gaaatactac ttggaaggag tctcaaatga aatgtacaca     2700

gaatatctct ccagtgcctt cgtgggtctg tccttcccta ctgtttgtga gctgtgtttt     2760

gtgaagctca agctcctaat gatagccatt gagtacaagt ctgccaaccg agagagccgt     2820

atattaatta atcctggaaa ccatcttaag atccaagaag gtactttagg atttttcatc     2880

gcaagtgatg ccaaagaagt taaaagggca tttttttact gcaaggcctg tcatgatgac     2940

atcacagatc ccaaaagaat aaaaaaatgt ggctgcaaac ggcttgaaga tgagcagccg     3000

tcaacactat caccaaaaaa aaagcaacgg aatggaggca tgcggaactc acccaacacc     3060

tcgcctaagc tgatgaggca tgaccccttg ttaattcctg gcaatgatca gattgacaac     3120

atggactcca atgtgaagaa gtacgactct actgggatgt ttcactggtg tgcacccaag     3180

gagatagaga aagtcatcct gactcgaagt gaagctgcca tgaccgtcct gagtggccat     3240

gtcgtggtct gcatctttgg cgacgtcagc tcagccctga tcggcctccg gaacctggtg     3300

atgccgctcc gtgccagcaa ctttcattac catgagctca agcacattgt gtttgtgggc     3360

tctattgagt acctcaagcg ggaatgggag acgcttcata acttccccaa agtgtccata     3420

ttgcctggta cgccattaag tcgggctgat ttaagggctg tcaacatcaa cctctgtgac     3480

atgtgcgtta tcctgtcagc caatcagaat aatattgatg atacttcgct gcaggacaag     3540

gaatgcatct tggcgtcact caacatcaaa tctatgcagt ttgatgacag catcggagtc     3600

ttgcaggcta attcccaagg gttcacacct ccaggaatgg atagatcctc tccagataac     3660

agcccagtgc acgggatgtt acgtcaacca tccatcacaa ctggggtcaa catccccatc     3720

atcactgaac tagtgaacga tactaatgtt cagtttttgg accaagacga tgatgatgac     3780

cctgatacag aactgtacct cacgcagccc tttgcctgtg ggacagcatt tgccgtcagt     3840

gtcctggact cactcatgag cgcgacgtac ttcaatgaca atatcctcac cctgatacgg     3900

accctggtga ccggaggagc cacgccggag ctggaggctc tgattgctga ggaaaacgcc     3960

cttagaggtg gctacagcac cccgcagaca ctggccaata gggaccgctg ccgcgtggcc     4020

cagttagctc tgctcgatgg gccatttgcg gacttagggg atggtggttg ttatggtgat     4080

ctgttctgca aagctctgaa aacatataat atgctttgtt ttggaattta ccggctgaga     4140

gatgctcacc tcagcacccc cagtcagtgc acaaagaggt atgtcatcac caacccgccc     4200

tatgagtttg agctcgtgcc gacggacctg atcttctgct taatgcagtt tgaccacaat     4260

gccggccagt cccgggccag cctgtcccat tcctcccact cgtcgcagtc ctccagcaag     4320

aagagctcct ctgttcactc catcccatcc acagcaaacc gacagaaccg gcccaagtcc     4380

agggagtccc gggacaaaca gaagtacgtg caggaagagc ggctttgata tgtgtatcca     4440

ccgccactgt gtgaaactgt atctgccact catttcccca gttggtgttt ccaacaaagt     4500

aactttcccc gttttcccct gtagtccccc cccttttttt ttacacatat ttgcatatgt     4560

atgatagtgt gcatgtggtt gtcattttta tttcaccacc ataaaaccct tgagcacaac     4620

agcaaataag cagacgggct ccggaattct gcagcccggg ggatccacta gttctagagg     4680

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     4740

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     4800

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     4860

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     4920

ggtgggctct atggcttcta ctgggcggtt ttatggacag caagcgaacc ggaattgcca     4980

gctggggcgc cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttctcg     5040

ccgccaagga tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg     5100

tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg     5160

ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg     5220

ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat     5280

gaactgcaag acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca     5340

gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg     5400

gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat     5460

gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa     5520

catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg     5580

gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg     5640

cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg     5700

gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat     5760

caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac     5820

cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc     5880

cttcttgacg agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc     5940

cttacgcatc tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc     6000

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     6060

aataaccctg ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa     6120

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     6180

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     6240

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     6300

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     6360

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     6420

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     6480

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     6540

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     6600

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     6660

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     6720

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     6780

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     6840

ggttcctggg cttttgctgg ccttttgctc acatgttctt                           6880


<210>  50
<211>  6879
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVax-hSlo Variant 2

<400>  50
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gcttcttgtt ctttttgcag aagctcagaa taaacgctca actttggcag      840

aatcgataag cttgatcgag cccctgcgcc tgccgcccat tgctagctat ggcaaacggt      900

ggcggcggcg gcggcggcag cagcggcggc ggcggcggcg gcggcggagg cagcggtctt      960

agaatgagca gcaatatcca cgcgaaccat ctcagcctag acgcgtcctc ctcctcctcc     1020

tcctcctctt cctcttcttc ttcttcctcc tcctcttcct cctcgtcctc ggtccacgag     1080

cccaagatgg atgcgctcat catcccggtg accatggagg tgccgtgcga cagccggggc     1140

caacgcatgt ggtgggcttt cctggcctcc tccatggtga ctttcttcgg gggcctcttc     1200

atcatcttgc tctggcggac gctcaagtac ctgtggaccg tgtgctgcca ctgcgggggc     1260

aagacgaagg aggcccagaa gattaacaat ggctcaagcc aggcggatgg cactctcaaa     1320

ccagtggatg aaaaagagga ggcagtggcc gccgaggtcg gctggatgac ctccgtgaag     1380

gactgggcgg gggtgatgat atccgcccag acactgactg gcagagtcct ggttgtctta     1440

gtctttgctc tcagcatcgg tgcacttgta atatacttca tagattcatc aaacccaata     1500

gaatcctgcc agaatttcta caaagatttc acattacaga tcgacatggc tttcaacgtg     1560

ttcttccttc tctacttcgg cttgcggttt attgcagcca acgataaatt gtggttctgg     1620

ctggaagtga actctgtagt ggatttcttc acggtgcccc ccgtgtttgt gtctgtgtac     1680

ttaaacagaa gttggcttgg tttgagattt ttaagagctc tgagactgat acagttttca     1740

gaaattttgc agtttctgaa tattcttaaa acaagtaatt ccatcaagct ggtgaatctg     1800

ctctccatat ttatcagcac gtggctgact gcagctgggt tcatccattt ggtggagaat     1860

tcaggggacc catgggaaaa tttccaaaac aaccaggctc tcacctactg ggaatgtgtc     1920

tatttactca tggtcacaat gtccaccgtt ggttatgggg atgtttatgc aaaaaccaca     1980

cttgggcgcc tcttcatggt cttcttcatc ctcgggggac tggccatgtt tgccagctac     2040

gtccctgaaa tcatagagtt aataggaaac cgcaagaaat acgggggctc ctatagtgcg     2100

gttagtggaa gaaagcacat tgtggtctgc ggacacatca ctctggagag tgtttccaac     2160

ttcctgaagg actttctgca caaggaccgg gatgacgtca atgtggagat cgtttttctt     2220

cacaacatct cccccaacct ggagcttgaa gctctgttca aacgacattt tactcaggtg     2280

gaattttatc agggttccgt cctcaatcca catgatcttg caagagtcaa gatagagtca     2340

gcagatgcat gcctgatcct tgccaacaag tactgcgctg acccggatgc ggaggatgcc     2400

tcgaatatca tgagagtaat ctccataaag aactaccatc cgaagataag aatcatcact     2460

caaatgctgc agtatcacaa caaggcccat ctgctaaaca tcccgagctg gaattggaaa     2520

gaaggtgatg acgcaatctg cctcgcagag ttgaagttgg gcttcatagc ccagagctgc     2580

ctggctcaag gcctctccac catgcttgcc aacctcttct ccatgaggtc attcataaag     2640

attgaggaag acacatggca gaaatactac ttggaaggag tctcaaatga aatgtacaca     2700

gaatatctct ccagtgcctt cgtgggtctg tccttcccta ctgtttgtga gctgtgtttt     2760

gtgaagctca agctcctaat gatagccatt gagtacaagt ctgccaaccg agagagccgt     2820

atattaatta atcctggaaa ccatcttaag atccaagaag gtactttagg atttttcatc     2880

gcaagtgatg ccaaagaagt taaaagggca tttttttact gcaaggcctg tcatgatgac     2940

atcacagatc ccaaaagaat aaaaaaatgt ggctgcaaac ggcttgaaga tgagcagccg     3000

tcaacactat caccaaaaaa aaagcaacgg aatggaggca tgcggaactc acccaacacc     3060

tcgcctaagc tgatgaggca tgaccccttg ttaattcctg gcaatgatca gattgacaac     3120

atggactcca atgtgaagaa gtacgactct actgggatgt ttcactggtg tgcacccaag     3180

gagatagaga aagtcatcct gactcgaagt gaagctgcca tgaccgtcct gagtggccat     3240

gtcgtggtct gcatctttgg cgacgtcagc tcagccctga tcggcctccg gaacctggtg     3300

atgccgctcc gtgccagcaa ctttcattac catgagctca agcacattgt gtttgtgggc     3360

tctattgagt acctcaagcg ggaatgggag acgcttcata acttccccaa agtgtccata     3420

ttgcctggta cgccattaag tcgggctgat ttaagggctg tcaacatcaa cctctgtgac     3480

atgtgcgtta tcctgtcagc caatcagaat aatattgatg atacttcgct gcaggacaag     3540

gaatgcatct tggcgtcact caacatcaaa tctatgcagt ttgatgacag catcggagtc     3600

ttgcaggcta attcccaagg gttcacacct ccaggaatgg atagatcctc tccagataac     3660

agcccagtgc acgggatgtt acgtcaacca tccatcacaa ctggggtcaa catccccatc     3720

atcactgaac tagtgaacga tactaatgtt cagtttttgg accaagacga tgatgatgac     3780

cctgatacag aactgtacct cacgcagccc tttgcctgtg ggacagcatt tgccgtcagt     3840

gtcctggact cactcatgag cgcgacgtac ttcaatgaca atatcctcac cctgatacgg     3900

accctggtga ccggaggagc cacgccggag ctggaggctc tgattgctga ggaaaacgcc     3960

cttagaggtg gctacagcac cccgcagaca ctggccaata gggaccgctg ccgcgtggcc     4020

cagttagctc tgctcgatgg gccatttgcg gacttagggg atggtggttg ttatggtgat     4080

ctgttctgca aagctctgaa aacatataat atgctttgtt ttggaattta ccggctgaga     4140

gatgctcacc tcagcacccc cagtcagtgc acaaagaggt atgtcatcac caacccgccc     4200

tatgagtttg agctcgtgcc gacggacctg atcttctgct taatgcagtt tgaccacaat     4260

gccggccagt cccgggccag cctgtcccat tcctcccact cgtcgcagtc ctccagcaag     4320

aagagctcct ctgttcactc catcccatcc acagcaaacc gacagaaccg gcccaagtcc     4380

agggagtccc gggacaaaca gaagtacgtg caggaagagc ggctttgata tgtgtatcca     4440

ccgccactgt gtgaaactgt atctgccact catttcccca gttggtgttt ccaacaaagt     4500

aactttccct gttttcccct gtagtccccc cctttttttt tacacatatt tgcatatgta     4560

tgatagtgtg catgtggttg tcatttttat ttcaccacca taaaaccctt gagcacaaca     4620

gcaaataagc agacgggctc cggaattcct gcagcccggg ggatccacta gttctagagg     4680

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     4740

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     4800

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     4860

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     4920

ggtgggctct atggcttcta ctgggcggtt ttatggacag caagcgaacc ggaattgcca     4980

gctggggcgc cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttcttg     5040

ccgccaagga tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg     5100

tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg     5160

ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg     5220

ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat     5280

gaactgcaag acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca     5340

gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg     5400

gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat     5460

gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa     5520

catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg     5580

gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg     5640

cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg     5700

gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat     5760

caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac     5820

cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc     5880

cttcttgacg agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc     5940

cttacgcatc tgtgcggtat ttcacaccgc atcaggtggc acttttcggg gaaatgtgcg     6000

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     6060

ataaccctga taaatgcttc aataatagca cgtgctaaaa cttcattttt aatttaaaag     6120

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     6180

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     6240

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     6300

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     6360

accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     6420

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     6480

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     6540

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     6600

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag     6660

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     6720

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     6780

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     6840

gttcctggcc ttttgctggc cttttgctca catgttctt                            6879


<210>  51
<211>  3538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVax-hSlo ORF

<400>  51
atggcaaacg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggcgga       60

ggcagcggtc ttagaatgag cagcaatatc cacgcgaacc atctcagcct agacgcgtcc      120

tcctcctcct cctcctcctc ttcctcttct tcttcttcct cctcctcttc ctcctcgtcc      180

tcggtccacg agcccaagat ggatgcgctc atcatcccgg tgaccatgga ggtgccgtgc      240

gacagccggg gccaacgcat gtggtgggct ttcctggcct cctccatggt gactttcttc      300

gggggcctct tcatcatctt gctctggcgg acgctcaagt acctgtggac cgtgtgctgc      360

cactgcgggg gcaagacgaa ggaggcccag aagattaaca atggctcaag ccaggcggat      420

ggcactctca aaccagtgga tgaaaaagag gaggcagtgg ccgccgaggt cggctggatg      480

acctccgtga aggactgggc gggggtgatg atatccgccc agacactgac tggcagagtc      540

ctggttgtct tagtctttgc tctcagcatc ggtgcacttg taatatactt catagattca      600

tcaaacccaa tagaatcctg ccagaatttc tacaaagatt tcacattaca gatcgacatg      660

gctttcaacg tgttcttcct tctctacttt ggcttgcggt ttattgcagc caacgataaa      720

ttgtggttct ggctggaagt gaactctgta gtggatttct tcacggtgcc ccccgtgttt      780

gtgtctgtgt acttaaacag aagttggctt ggtttgagat ttttaagagc tctgagactg      840

atacagtttt cagaaatttt gcagtttctg aatattctta aaacaagtaa ttccatcaag      900

ctggtgaatc tgctctccat atttatcagc acgtggctga ctgcagctgg gttcatccat      960

ttggtggaga attcagggga cccatgggaa aatttccaaa acaaccaggc tctcacctac     1020

tgggaatgtg tctatttact catggtcaca atgtccaccg ttggttatgg ggatgtttat     1080

gcaaaaacca cacttcggcg cctcttcatg gtcttcttca tcctcggggg actggccatg     1140

tttgccagct acgtccctga aatcatagag ttaataggaa accgcaagaa atacgggggc     1200

tcctatagtg cggttagtgg aagaaagcac attgtggtct gcggacacat cactctggag     1260

agtgtttcca acttcctgaa ggactttctg cacaaggacc gggatgacgt caatgtggag     1320

atcgtttttc ttcacaacat ctcccccaac ctggagcttg aagctctgtt caaacgacat     1380

tttactcagg tggaatttta tcagggttcc gtcctcaatc cacatgatct tgcaagagtc     1440

aagatagagt cagcagatgc atgcctgatc cttgccaaca agtactgcgc tgacccggat     1500

gcggaggatg cctcgaatat catgagagta atctccataa agaactacca tccgaagata     1560

agaatcatca ctcaaatgct gcagtatcac aacaaggccc atctgctaaa catcccgagc     1620

tggaattgga aagaaggtga tgacgcaatc tgcctcgcag agttgaagtt gggcttcata     1680

gcccagagct gcctggctca aggcctctcc accatgcttg ccaacctctt ctccatgagg     1740

tcattcataa agattgagga agacacatgg cagaaatact acttggaagg agtctcaaat     1800

gaaatgtaca cagaatatct ctccagtgcc ttcgtgggtc tgtccttccc tactgtttgt     1860

gagctgtgtt ttgtgaagct caagctccta atgatagcca ttgagtacaa gtctgccaac     1920

cgagagagcc gtatattaat taatcctgga aaccatctta agatccaaga aggtacttta     1980

ggatttttca tcgcaagtga tgccaaagaa gttaaaaggg cattttttta ctgcaaggcc     2040

tgtcatgatg acatcacaga tcccaaaaga ataaaaaaat gtggctgcaa acggcttgaa     2100

gatgagcagc cgtcaacact atcaccaaaa aaaaagcaac ggaatggagg catgcggaac     2160

tcacccaaca cctcgcctaa gctgatgagg catgacccct tgttaattcc tggcaatgat     2220

cagattgaca acatggactc caatgtgaag aagtacgact ctactgggat gtttcactgg     2280

tgtgcaccca aggagataga gaaagtcatc ctgactcgaa gtgaagctgc catgaccgtc     2340

ctgagtggcc atgtcgtggt ctgcatcttt ggcgacgtca gctcagccct gatcggcctc     2400

cggaacctgg tgatgccgct ccgtgccagc aactttcatt accatgagct caagcacatt     2460

gtgtttgtgg gctctattga gtacctcaag cgggaatggg agacgcttca taacttcccc     2520

aaagtgtcca tattgcctgg tacgccatta agtcgggctg atttaagggc tgtcaacatc     2580

aacctctgtg acatgtgcgt tatcctgtca gccaatcaga ataatattga tgatacttcg     2640

ctgcaggaca aggaatgcat cttggcgtca ctcaacatca aatctatgca gtttgatgac     2700

agcatcggag tcttgcaggc taattcccaa gggttcacac ctccaggaat ggatagatcc     2760

tctccagata acagcccagt gcacgggatg ttacgtcaac catccatcac aactggggtc     2820

aacatcccca tcatcactga actagtgaac gatactaatg ttcagttttt ggaccaagac     2880

gatgatgatg accctgatac agaactgtac ctcacgcagc cctttgcctg tgggacagca     2940

tttgccgtca gtgtcctgga ctcactcatg agcgcgacgt acttcaatga caatatcctc     3000

accctgatac ggaccctggt gaccggagga gccacgccgg agctggaggc tctgattgct     3060

gaggaaaacg cccttagagg tggctacagc accccgcaga cactggccaa tagggaccgc     3120

tgccgcgtgg cccagttagc tctgctcgat gggccatttg cggacttagg ggatggtggt     3180

tgttatggtg atctgttctg caaagctctg aaaacatata atatgctttg ttttggaatt     3240

taccggctga gagatgctca cctcagcacc cccagtcagt gcacaaagag gtatgtcatc     3300

accaacccgc cctatgagtt tgagctcgtg ccgacggacc tgatcttctg cttaatgcag     3360

tttgaccaca atgccggcca gtcccgggcc agcctgtccc attcctccca ctcgtcgcag     3420

tcctccagca agaagagctc ctctgttcac tccatcccat ccacagcaaa ccgacagaac     3480

cggcccaagt ccagggagtc ccgggacaaa cagaagtacg tgcaggaaga gcggcttt       3538


<210>  52
<211>  3538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVax-hSlo ORF

<400>  52
atggcaaacg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggcgga       60

ggcagcagtc ttagaatgag tagcaatatc cacgcgaacc atctcagcct agacgcgtcc      120

tcctcctcct cctcctcctc ttcctcttct tcttcttcct cctcctcttc ctcctcgtcc      180

tcggtccacg agcccaagat ggatgcgctc atcatcccgg tgaccatgga ggtgccgtgc      240

gacagccggg gccaacgcat gtggtgggct ttcctggcct cctccatggt gactttcttc      300

gggggcctct tcatcatctt gctctggcgg acgctcaagt acctgtggac cgtgtgctgc      360

cactgcgggg gcaagacgaa ggaggcccag aagattaaca atggctcaag ccaggcggat      420

ggcactctca aaccagtgga tgaaaaagag gaggcagtgg ccgccgaggt cggctggatg      480

acctccgtga aggactgggc gggggtgatg atatccgccc agacactgac tggcagagtc      540

ctggttgtct tagtctttgc tctcagcatc ggtgcacttg taatatactt catagattca      600

tcaaacccaa tagaatcctg ccagaatttc tacaaagatt tcacattaca gatcgacatg      660

gctttcaacg tgttcttcct tctctacttc ggcttgcggt ttattgcagc caacgataaa      720

ttgtggttct ggctggaagt gaactctgta gtggatttct tcacggtgcc ccccgtgttt      780

gtgtctgtgt acttaaacag aagttggctt ggtttgagat ttttaagagc tctgagactg      840

atacagtttt cagaaatttt gcagtttctg aatattctta aaacaagtaa ttccatcaag      900

ctggtgaatc tgctctccat atttatcagc acgtggctga ctgcagccgg gttcatccat      960

ttggtggaga attcagggga cccatgggaa aatttccaaa acaaccaggc tctcacctac     1020

tgggaatgtg tctatttact catggtcaca atgtccaccg ttggttatgg ggatgtttat     1080

gcaaaaacca cacttgggcg cctcttcatg gtcttcttca tcctcggggg actggccatg     1140

tttgccagct acgtccctga aatcatagag ttaataggaa accgcaagaa atacgggggc     1200

tcctatagtg cggttagtgg aagaaagcac attgtggtct gcggacacat cactctggag     1260

agtgtttcca acttcctgaa ggactttctg cacaaggacc gggatgacgt caatgtggag     1320

atcgtttttc ttcacaacat ctcccccaac ctggagcttg aagctctgtt caaacgacat     1380

tttactcagg tggaatttta tcagggttcc gtcctcaatc cacatgatct tgcaagagtc     1440

aagatagagt cagcagatgc atgcctgatc cttgccaaca agtactgcgc tgacccggat     1500

gcggaggatg cctcgaatat catgagagta atctccataa agaactacca tccgaagata     1560

agaatcatca ctcaaatgct gcagtatcac aacaaggccc atctgctaaa catcccgagc     1620

tggaattgga aagaaggtga tgacgcaatc tgcctcgcag agttgaagtt gggcttcata     1680

gcccagagct gcctggctca aggcctctcc accatgcttg ccaacctctt ctccatgagg     1740

tcattcataa agattgagga agacacatgg cagaaatact acttggaagg agtctcaaat     1800

gaaatgtaca cagaatatct ctccagtgcc ttcgtgggtc tgtccttccc tactgtttgt     1860

gagctgtgtt ttgtgaagct caagctccta atgatagcca ttgagtacaa gtctgccaac     1920

cgagagagcc gtatattaat taatcctgga aaccatctta agatccaaga aggtacttta     1980

ggatttttca tcgcaagtga tgccaaagaa gttaaaaggg cattttttta ctgcaaggcc     2040

tgtcatgatg acatcacaga tcccaaaaga ataaaaaaat gtggctgcaa acggcttgaa     2100

gatgagcagc cgtcaacact atcaccaaaa aaaaagcaac ggaatggagg catgcggaac     2160

tcacccaaca cctcgcctaa gctgatgagg catgacccct tgttaattcc tggcaatgat     2220

cagattgaca acatggactc caatgtgaag aagtacgact ctactgggat gtttcactgg     2280

tgtgcaccca aggagataga gaaagtcatc ctgactcgaa gtgaagctgc catgaccgtc     2340

ctgagtggcc atgtcgtggt ctgcatcttt ggcgacgtca gctcagccct gatcggcctc     2400

cggaacctgg tgatgccgct ccgtgccagc aactttcatt accatgagct caagcacatt     2460

gtgtttgtgg gctctattga gtacctcaag cgggaatggg agacgcttca taacttcccc     2520

aaagtgtcca tattgcctgg tacgccatta agtcgggctg atttaagggc tgtcaacatc     2580

aacctctgtg acatgtgcgt tatcctgtca gccaatcaga ataatattga tgatacttcg     2640

ctgcaggaca aggaatgcat cttggcgtca ctcaacatca aatctatgca gtttgatgac     2700

agcatcggag tcttgcaggc taattcccaa gggttcacac ctccaggaat ggatagatcc     2760

tctccagata acagcccagt gcacgggatg ttacgtcaac catccatcac aactggggtc     2820

aacatcccca tcatcactga actagtgaac gatactaatg ttcagttttt ggaccaagac     2880

gatgatgatg accctgatac agaactgtac ctcacgcagc cctttgcctg tgggacagca     2940

tttgccgtca gtgtcctgga ctcactcatg agcgcgacgt acttcaatga caatatcctc     3000

accctgatac ggaccctggt gaccggagga gccacgccgg agctggaggc tctgattgct     3060

gaggaaaacg cccttagagg tggctacagc accccgcaga cactggccaa tagggaccgc     3120

tgccgcgtgg cccagttagc tctgctcgat gggccatttg cggacttagg ggatggtggt     3180

tgttatggtg atctgttctg caaagctctg aaaacatata atatgctttg ttttggaatt     3240

taccggctga gagatgctca cctcagcacc cccagtcagt gcacaaagag gtatgtcatc     3300

accaacccgc cctatgagtt tgagctcgtg ccgacggacc tgatcttctg cttaatgcag     3360

tttgaccaca atgccggcca gtcccgggcc agcctgtccc attcctccca ctcgtcgcag     3420

tcctccagca agaagagctc ctctgttcac tccatcccat ccacagcaaa ccgacagaac     3480

cggcccaagt ccagggagtc ccgggacaaa cagaagtacg tgcaggaaga gcggcttt       3538


<210>  53
<211>  3538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVax-hSlo ORF

<400>  53
atggcaaacg gtggcggcgg cggcggcggc agcagcggcg gcggcggcgg cggcggcgga       60

ggcagcggtc ttagaatgag cagcaatatc cacgcgaacc atctcagcct agacgcgtcc      120

tcctcctcct cctcctcctc ttcctcttct tcttcttcct cctcctcttc ctcctcgtcc      180

tcggtccacg agcccaagat ggatgcgctc atcatcccgg tgaccatgga ggtgccgtgc      240

gacagccggg gccaacgcat gtggtgggct ttcctggcct cctccatggt gactttcttc      300

gggggcctct tcatcatctt gctctggcgg acgctcaagt acctgtggac cgtgtgctgc      360

cactgcgggg gcaagacgaa ggaggcccag aagattaaca atggctcaag ccaggcggat      420

ggcactctca aaccagtgga tgaaaaagag gaggcagtgg ccgccgaggt cggctggatg      480

acctccgtga aggactgggc gggggtgatg atatccgccc agacactgac tggcagagtc      540

ctggttgtct tagtctttgc tctcagcatc ggtgcacttg taatatactt catagattca      600

tcaaacccaa tagaatcctg ccagaatttc tacaaagatt tcacattaca gatcgacatg      660

gctttcaacg tgttcttcct tctctacttc ggcttgcggt ttattgcagc caacgataaa      720

ttgtggttct ggctggaagt gaactctgta gtggatttct tcacggtgcc ccccgtgttt      780

gtgtctgtgt acttaaacag aagttggctt ggtttgagat ttttaagagc tctgagactg      840

atacagtttt cagaaatttt gcagtttctg aatattctta aaacaagtaa ttccatcaag      900

ctggtgaatc tgctctccat atttatcagc acgtggctga ctgcagctgg gttcatccat      960

ttggtggaga attcagggga cccatgggaa aatttccaaa acaaccaggc tctcacctac     1020

tgggaatgtg tctatttact catggtcaca atgtccaccg ttggttatgg ggatgtttat     1080

gcaaaaacca cacttgggcg cctcttcatg gtcttcttca tcctcggggg actggccatg     1140

tttgccagct acgtccctga aatcatagag ttaataggaa accgcaagaa atacgggggc     1200

tcctatagtg cggttagtgg aagaaagcac attgtggtct gcggacacat cactctggag     1260

agtgtttcca acttcctgaa ggactttctg cacaaggacc gggatgacgt caatgtggag     1320

atcgtttttc ttcacaacat ctcccccaac ctggagcttg aagctctgtt caaacgacat     1380

tttactcagg tggaatttta tcagggttcc gtcctcaatc cacatgatct tgcaagagtc     1440

aagatagagt cagcagatgc atgcctgatc cttgccaaca agtactgcgc tgacccggat     1500

gcggaggatg cctcgaatat catgagagta atctccataa agaactacca tccgaagata     1560

agaatcatca ctcaaatgct gcagtatcac aacaaggccc atctgctaaa catcccgagc     1620

tggaattgga aagaaggtga tgacgcaatc tgcctcgcag agttgaagtt gggcttcata     1680

gcccagagct gcctggctca aggcctctcc accatgcttg ccaacctctt ctccatgagg     1740

tcattcataa agattgagga agacacatgg cagaaatact acttggaagg agtctcaaat     1800

gaaatgtaca cagaatatct ctccagtgcc ttcgtgggtc tgtccttccc tactgtttgt     1860

gagctgtgtt ttgtgaagct caagctccta atgatagcca ttgagtacaa gtctgccaac     1920

cgagagagcc gtatattaat taatcctgga aaccatctta agatccaaga aggtacttta     1980

ggatttttca tcgcaagtga tgccaaagaa gttaaaaggg cattttttta ctgcaaggcc     2040

tgtcatgatg acatcacaga tcccaaaaga ataaaaaaat gtggctgcaa acggcttgaa     2100

gatgagcagc cgtcaacact atcaccaaaa aaaaagcaac ggaatggagg catgcggaac     2160

tcacccaaca cctcgcctaa gctgatgagg catgacccct tgttaattcc tggcaatgat     2220

cagattgaca acatggactc caatgtgaag aagtacgact ctactgggat gtttcactgg     2280

tgtgcaccca aggagataga gaaagtcatc ctgactcgaa gtgaagctgc catgaccgtc     2340

ctgagtggcc atgtcgtggt ctgcatcttt ggcgacgtca gctcagccct gatcggcctc     2400

cggaacctgg tgatgccgct ccgtgccagc aactttcatt accatgagct caagcacatt     2460

gtgtttgtgg gctctattga gtacctcaag cgggaatggg agacgcttca taacttcccc     2520

aaagtgtcca tattgcctgg tacgccatta agtcgggctg atttaagggc tgtcaacatc     2580

aacctctgtg acatgtgcgt tatcctgtca gccaatcaga ataatattga tgatacttcg     2640

ctgcaggaca aggaatgcat cttggcgtca ctcaacatca aatctatgca gtttgatgac     2700

agcatcggag tcttgcaggc taattcccaa gggttcacac ctccaggaat ggatagatcc     2760

tctccagata acagcccagt gcacgggatg ttacgtcaac catccatcac aactggggtc     2820

aacatcccca tcatcactga actagtgaac gatactaatg ttcagttttt ggaccaagac     2880

gatgatgatg accctgatac agaactgtac ctcacgcagc cctttgcctg tgggacagca     2940

tttgccgtca gtgtcctgga ctcactcatg agcgcgacgt acttcaatga caatatcctc     3000

accctgatac ggaccctggt gaccggagga gccacgccgg agctggaggc tctgattgct     3060

gaggaaaacg cccttagagg tggctacagc accccgcaga cactggccaa tagggaccgc     3120

tgccgcgtgg cccagttagc tctgctcgat gggccatttg cggacttagg ggatggtggt     3180

tgttatggtg atctgttctg caaagctctg aaaacatata atatgctttg ttttggaatt     3240

taccggctga gagatgctca cctcagcacc cccagtcagt gcacaaagag gtatgtcatc     3300

accaacccgc cctatgagtt tgagctcgtg ccgacggacc tgatcttctg cttaatgcag     3360

tttgaccaca atgccggcca gtcccgggcc agcctgtccc attcctccca ctcgtcgcag     3420

tcctccagca agaagagctc ctctgttcac tccatcccat ccacagcaaa ccgacagaac     3480

cggcccaagt ccagggagtc ccgggacaaa cagaagtacg tgcaggaaga gcggcttt       3538


<210>  54
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hSlo - Translated ORF

<400>  54

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ser Gly Leu Arg Met Ser Ser Asn Ile His Ala 
            20                  25                  30          


Asn His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu 
    50                  55                  60                  


Pro Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys 
65                  70                  75                  80  


Asp Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met 
                85                  90                  95      


Val Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu 
            100                 105                 110         


Lys Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu 
        115                 120                 125             


Ala Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys 
    130                 135                 140                 


Pro Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met 
145                 150                 155                 160 


Thr Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu 
                165                 170                 175     


Thr Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala 
            180                 185                 190         


Leu Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln 
        195                 200                 205             


Asn Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val 
    210                 215                 220                 


Phe Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys 
225                 230                 235                 240 


Leu Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val 
                245                 250                 255     


Pro Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu 
            260                 265                 270         


Arg Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln 
        275                 280                 285             


Phe Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu 
    290                 295                 300                 


Leu Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His 
305                 310                 315                 320 


Leu Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln 
                325                 330                 335     


Ala Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser 
            340                 345                 350         


Thr Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Arg Arg Leu 
        355                 360                 365             


Phe Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr 
    370                 375                 380                 


Val Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly 
385                 390                 395                 400 


Ser Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His 
                405                 410                 415     


Ile Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys 
            420                 425                 430         


Asp Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser 
        435                 440                 445             


Pro Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val 
    450                 455                 460                 


Glu Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val 
465                 470                 475                 480 


Lys Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys 
                485                 490                 495     


Ala Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser 
            500                 505                 510         


Ile Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln 
        515                 520                 525             


Tyr His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys 
    530                 535                 540                 


Glu Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile 
545                 550                 555                 560 


Ala Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu 
                565                 570                 575     


Phe Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys 
            580                 585                 590         


Tyr Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser 
        595                 600                 605             


Ser Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe 
    610                 615                 620                 


Val Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn 
625                 630                 635                 640 


Arg Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln 
                645                 650                 655     


Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys 
            660                 665                 670         


Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro 
        675                 680                 685             


Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro 
    690                 695                 700                 


Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn 
705                 710                 715                 720 


Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile 
                725                 730                 735     


Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr 
            740                 745                 750         


Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys 
        755                 760                 765             


Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His 
    770                 775                 780                 


Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu 
785                 790                 795                 800 


Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu 
                805                 810                 815     


Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu 
            820                 825                 830         


Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr 
        835                 840                 845             


Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp 
    850                 855                 860                 


Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser 
865                 870                 875                 880 


Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met 
                885                 890                 895     


Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe 
            900                 905                 910         


Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His 
        915                 920                 925             


Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile 
    930                 935                 940                 


Ile Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp 
945                 950                 955                 960 


Asp Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala 
                965                 970                 975     


Cys Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala 
            980                 985                 990         


Thr Tyr Phe Asn Asp Asn Ile Leu  Thr Leu Ile Arg Thr  Leu Val Thr 
        995                 1000                 1005             


Gly Gly  Ala Thr Pro Glu Leu  Glu Ala Leu Ile Ala  Glu Glu Asn 
    1010                 1015                 1020             


Ala Leu  Arg Gly Gly Tyr Ser  Thr Pro Gln Thr Leu  Ala Asn Arg 
    1025                 1030                 1035             


Asp Arg  Cys Arg Val Ala Gln  Leu Ala Leu Leu Asp  Gly Pro Phe 
    1040                 1045                 1050             


Ala Asp  Leu Gly Asp Gly Gly  Cys Tyr Gly Asp Leu  Phe Cys Lys 
    1055                 1060                 1065             


Ala Leu  Lys Thr Tyr Asn Met  Leu Cys Phe Gly Ile  Tyr Arg Leu 
    1070                 1075                 1080             


Arg Asp  Ala His Leu Ser Thr  Pro Ser Gln Cys Thr  Lys Arg Tyr 
    1085                 1090                 1095             


Val Ile  Thr Asn Pro Pro Tyr  Glu Phe Glu Leu Val  Pro Thr Asp 
    1100                 1105                 1110             


Leu Ile  Phe Cys Leu Met Gln  Phe Asp His Asn Ala  Gly Gln Ser 
    1115                 1120                 1125             


Arg Ala  Ser Leu Ser His Ser  Ser His Ser Ser Gln  Ser Ser Ser 
    1130                 1135                 1140             


Lys Lys  Ser Ser Ser Val His  Ser Ile Pro Ser Thr  Ala Asn Arg 
    1145                 1150                 1155             


Gln Asn  Arg Pro Lys Ser Arg  Glu Ser Arg Asp Lys  Gln Lys Tyr 
    1160                 1165                 1170             


Val Gln  Glu Glu Arg Leu 
    1175                 


<210>  55
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hSlo - Translated ORF

<400>  55

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala 
            20                  25                  30          


Asn His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu 
    50                  55                  60                  


Pro Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys 
65                  70                  75                  80  


Asp Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met 
                85                  90                  95      


Val Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu 
            100                 105                 110         


Lys Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu 
        115                 120                 125             


Ala Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys 
    130                 135                 140                 


Pro Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met 
145                 150                 155                 160 


Thr Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu 
                165                 170                 175     


Thr Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala 
            180                 185                 190         


Leu Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln 
        195                 200                 205             


Asn Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val 
    210                 215                 220                 


Phe Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys 
225                 230                 235                 240 


Leu Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val 
                245                 250                 255     


Pro Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu 
            260                 265                 270         


Arg Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln 
        275                 280                 285             


Phe Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu 
    290                 295                 300                 


Leu Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His 
305                 310                 315                 320 


Leu Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln 
                325                 330                 335     


Ala Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser 
            340                 345                 350         


Thr Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu 
        355                 360                 365             


Phe Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr 
    370                 375                 380                 


Val Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly 
385                 390                 395                 400 


Ser Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His 
                405                 410                 415     


Ile Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys 
            420                 425                 430         


Asp Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser 
        435                 440                 445             


Pro Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val 
    450                 455                 460                 


Glu Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val 
465                 470                 475                 480 


Lys Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys 
                485                 490                 495     


Ala Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser 
            500                 505                 510         


Ile Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln 
        515                 520                 525             


Tyr His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys 
    530                 535                 540                 


Glu Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile 
545                 550                 555                 560 


Ala Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu 
                565                 570                 575     


Phe Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys 
            580                 585                 590         


Tyr Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser 
        595                 600                 605             


Ser Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe 
    610                 615                 620                 


Val Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn 
625                 630                 635                 640 


Arg Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln 
                645                 650                 655     


Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys 
            660                 665                 670         


Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro 
        675                 680                 685             


Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro 
    690                 695                 700                 


Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn 
705                 710                 715                 720 


Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile 
                725                 730                 735     


Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr 
            740                 745                 750         


Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys 
        755                 760                 765             


Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His 
    770                 775                 780                 


Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu 
785                 790                 795                 800 


Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu 
                805                 810                 815     


Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu 
            820                 825                 830         


Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr 
        835                 840                 845             


Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp 
    850                 855                 860                 


Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser 
865                 870                 875                 880 


Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met 
                885                 890                 895     


Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe 
            900                 905                 910         


Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His 
        915                 920                 925             


Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile 
    930                 935                 940                 


Ile Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp 
945                 950                 955                 960 


Asp Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala 
                965                 970                 975     


Cys Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala 
            980                 985                 990         


Thr Tyr Phe Asn Asp Asn Ile Leu  Thr Leu Ile Arg Thr  Leu Val Thr 
        995                 1000                 1005             


Gly Gly  Ala Thr Pro Glu Leu  Glu Ala Leu Ile Ala  Glu Glu Asn 
    1010                 1015                 1020             


Ala Leu  Arg Gly Gly Tyr Ser  Thr Pro Gln Thr Leu  Ala Asn Arg 
    1025                 1030                 1035             


Asp Arg  Cys Arg Val Ala Gln  Leu Ala Leu Leu Asp  Gly Pro Phe 
    1040                 1045                 1050             


Ala Asp  Leu Gly Asp Gly Gly  Cys Tyr Gly Asp Leu  Phe Cys Lys 
    1055                 1060                 1065             


Ala Leu  Lys Thr Tyr Asn Met  Leu Cys Phe Gly Ile  Tyr Arg Leu 
    1070                 1075                 1080             


Arg Asp  Ala His Leu Ser Thr  Pro Ser Gln Cys Thr  Lys Arg Tyr 
    1085                 1090                 1095             


Val Ile  Thr Asn Pro Pro Tyr  Glu Phe Glu Leu Val  Pro Thr Asp 
    1100                 1105                 1110             


Leu Ile  Phe Cys Leu Met Gln  Phe Asp His Asn Ala  Gly Gln Ser 
    1115                 1120                 1125             


Arg Ala  Ser Leu Ser His Ser  Ser His Ser Ser Gln  Ser Ser Ser 
    1130                 1135                 1140             


Lys Lys  Ser Ser Ser Val His  Ser Ile Pro Ser Thr  Ala Asn Arg 
    1145                 1150                 1155             


Gln Asn  Arg Pro Lys Ser Arg  Glu Ser Arg Asp Lys  Gln Lys Tyr 
    1160                 1165                 1170             


Val Gln  Glu Glu Arg Leu 
    1175                 


<210>  56
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hSlo - Translated ORF

<400>  56

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ser Gly Leu Arg Met Ser Ser Asn Ile His Ala 
            20                  25                  30          


Asn His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu 
    50                  55                  60                  


Pro Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys 
65                  70                  75                  80  


Asp Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met 
                85                  90                  95      


Val Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu 
            100                 105                 110         


Lys Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu 
        115                 120                 125             


Ala Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys 
    130                 135                 140                 


Pro Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met 
145                 150                 155                 160 


Thr Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu 
                165                 170                 175     


Thr Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala 
            180                 185                 190         


Leu Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln 
        195                 200                 205             


Asn Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val 
    210                 215                 220                 


Phe Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys 
225                 230                 235                 240 


Leu Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val 
                245                 250                 255     


Pro Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu 
            260                 265                 270         


Arg Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln 
        275                 280                 285             


Phe Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu 
    290                 295                 300                 


Leu Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His 
305                 310                 315                 320 


Leu Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln 
                325                 330                 335     


Ala Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser 
            340                 345                 350         


Thr Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu 
        355                 360                 365             


Phe Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr 
    370                 375                 380                 


Val Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly 
385                 390                 395                 400 


Ser Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His 
                405                 410                 415     


Ile Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys 
            420                 425                 430         


Asp Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser 
        435                 440                 445             


Pro Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val 
    450                 455                 460                 


Glu Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val 
465                 470                 475                 480 


Lys Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys 
                485                 490                 495     


Ala Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser 
            500                 505                 510         


Ile Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln 
        515                 520                 525             


Tyr His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys 
    530                 535                 540                 


Glu Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile 
545                 550                 555                 560 


Ala Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu 
                565                 570                 575     


Phe Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys 
            580                 585                 590         


Tyr Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser 
        595                 600                 605             


Ser Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe 
    610                 615                 620                 


Val Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn 
625                 630                 635                 640 


Arg Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln 
                645                 650                 655     


Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys 
            660                 665                 670         


Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro 
        675                 680                 685             


Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro 
    690                 695                 700                 


Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn 
705                 710                 715                 720 


Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile 
                725                 730                 735     


Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr 
            740                 745                 750         


Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys 
        755                 760                 765             


Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His 
    770                 775                 780                 


Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu 
785                 790                 795                 800 


Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu 
                805                 810                 815     


Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu 
            820                 825                 830         


Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr 
        835                 840                 845             


Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp 
    850                 855                 860                 


Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser 
865                 870                 875                 880 


Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met 
                885                 890                 895     


Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe 
            900                 905                 910         


Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His 
        915                 920                 925             


Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile 
    930                 935                 940                 


Ile Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp 
945                 950                 955                 960 


Asp Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala 
                965                 970                 975     


Cys Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala 
            980                 985                 990         


Thr Tyr Phe Asn Asp Asn Ile Leu  Thr Leu Ile Arg Thr  Leu Val Thr 
        995                 1000                 1005             


Gly Gly  Ala Thr Pro Glu Leu  Glu Ala Leu Ile Ala  Glu Glu Asn 
    1010                 1015                 1020             


Ala Leu  Arg Gly Gly Tyr Ser  Thr Pro Gln Thr Leu  Ala Asn Arg 
    1025                 1030                 1035             


Asp Arg  Cys Arg Val Ala Gln  Leu Ala Leu Leu Asp  Gly Pro Phe 
    1040                 1045                 1050             


Ala Asp  Leu Gly Asp Gly Gly  Cys Tyr Gly Asp Leu  Phe Cys Lys 
    1055                 1060                 1065             


Ala Leu  Lys Thr Tyr Asn Met  Leu Cys Phe Gly Ile  Tyr Arg Leu 
    1070                 1075                 1080             


Arg Asp  Ala His Leu Ser Thr  Pro Ser Gln Cys Thr  Lys Arg Tyr 
    1085                 1090                 1095             


Val Ile  Thr Asn Pro Pro Tyr  Glu Phe Glu Leu Val  Pro Thr Asp 
    1100                 1105                 1110             


Leu Ile  Phe Cys Leu Met Gln  Phe Asp His Asn Ala  Gly Gln Ser 
    1115                 1120                 1125             


Arg Ala  Ser Leu Ser His Ser  Ser His Ser Ser Gln  Ser Ser Ser 
    1130                 1135                 1140             


Lys Lys  Ser Ser Ser Val His  Ser Ile Pro Ser Thr  Ala Asn Arg 
    1145                 1150                 1155             


Gln Asn  Arg Pro Lys Ser Arg  Glu Ser Arg Asp Lys  Gln Lys Tyr 
    1160                 1165                 1170             


Val Gln  Glu Glu Arg Leu 
    1175                 


