                         SEQUENCE LISTING

<110>  ҩҵϺɷ޹˾
 
<120>  HER2/PD1˫Կ

<130>  SH363-19P422635

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Composite

<400>  1

Ser Tyr Asp Met Ser 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  Composite

<400>  2

Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


<210>  3
<211>  8
<212>  PRT
<213>  Composite

<400>  3

Pro Tyr Gly Gly Tyr Phe Asp Val 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Composite

<400>  4

Arg Ala Ser Gln Ser Ile Ser Asn Phe Leu His 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Composite

<400>  5

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Composite

<400>  6

Gln Gln Ser Asn Ser Trp Pro His Thr 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Composite

<400>  7

Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Composite

<400>  8

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  11
<212>  PRT
<213>  Composite

<400>  9

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Composite

<400>  10

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Composite

<400>  11

Ser Ala Ser Phe Leu Tyr Ser Gly 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Composite

<400>  12

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  13
<211>  117
<212>  PRT
<213>  Composite

<400>  13

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser His Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  107
<212>  PRT
<213>  Composite

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Phe 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  120
<212>  PRT
<213>  Composite

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  107
<212>  PRT
<213>  Composite

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  20
<212>  PRT
<213>  Composite

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  18
<211>  15
<212>  PRT
<213>  Composite

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  244
<212>  PRT
<213>  Composite

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Phe 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr Asp 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ala 
                165                 170                 175     


Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser His Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Ser Pro Tyr Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  20
<211>  709
<212>  PRT
<213>  Composite

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn 
                485                 490                 495     


Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
            500                 505                 510         


Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser 
        515                 520                 525             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
    530                 535                 540                 


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro 
545                 550                 555                 560 


His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        595                 600                 605             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
    610                 615                 620                 


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
625                 630                 635                 640 


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Thr Val 
                645                 650                 655     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser His Tyr 
            660                 665                 670         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
        675                 680                 685             


Ala Ser Pro Tyr Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
    690                 695                 700                 


Val Thr Val Ser Ser 
705                 


<210>  21
<211>  214
<212>  PRT
<213>  Composite

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  22
<211>  2127
<212>  DNA
<213>  Composite

<400>  22
gaggtccaac tggtggagtc cggaggagga ctggtgcaac ccggcggatc cctccggctg       60

tcttgtgctg ctagcggctt taacatcaag gatacctata tccattgggt taggcaagct      120

cccggtaagg gcttagaatg ggtcgctagg atctacccca ccaatggcta tactcgttac      180

gccgacagcg tgaagggtcg gttcaccatc tccgctgaca cctccaagaa cacagcttac      240

ctccaaatga actctttacg ggccgaggac acagccgtgt actactgttc ccggtgggga      300

ggcgacggct tctatgctat ggattactgg ggccaaggta ctttagtgac agtgtccagc      360

gccagcacaa aaggaccttc cgtcttccct ctggctccct cctccaagag caccagcggc      420

ggaacagctg ctctcggctg tctggtgaag gactacttcc ccgaacccgt taccgtgtct      480

tggaattccg gcgctttaac ctccggcgtg cacacctttc ccgctgtttt acagagcagc      540

ggcctctatt ctttaagctc cgtggtcaca gtgcctagca gctctttagg cacccagacc      600

tacatctgca acgtgaacca taagcccagc aataccaagg tcgacaagaa ggtggagccc      660

aagagctgcg ataagaccca cacatgtcct ccttgtcccg ctcccgaact gctgggagga      720

cccagcgtgt ttttattccc ccccaaaccc aaagacaccc tcatgatcag ccggaccccc      780

gaggtcacat gcgtggtggt ggacgtctcc cacgaagacc ccgaagtcaa gttcaactgg      840

tacgtggacg gagtcgaggt gcataacgcc aagacaaaac cccgggagga gcaatacaac      900

tccacctatc gtgtggtgag cgtgctcacc gtgctgcatc aagattggct gaatggcaag      960

gagtacaagt gcaaggtcag caacaaggct ctgcccgctc ctatcgagaa gacaatcagc     1020

aaagccaaag gccaaccccg ggagccccaa gtgtatactt tacccccctc ccgggaagag     1080

atgaccaaga accaagtttc tttaacatgt ttagtgaaag gcttttaccc ctccgacatc     1140

gccgtcgagt gggagtccaa tggccagccc gaaaataact acaagacaac cccccccgtg     1200

ctcgattccg atggatcctt ctttttatac agcaagctca cagtggataa gtcccggtgg     1260

cagcaaggaa acgtgttttc ttgttccgtc atgcacgagg ccctccataa ccactacacc     1320

cagaaatccc tctctctcag ccccggtaaa ggcggaggag gatccggcgg cggcggaagc     1380

ggaggaggcg gctccgagat cgtgctgacc cagtcccccg ctacactgtc cctctctccc     1440

ggtgaacggg ctactttaag ctgtcgtgcc agccaaagca tcagcaactt tttacactgg     1500

taccaacaga aacccggcca agctccccgg ctgctgatca agtacgcttc ccagagcatc     1560

agcggcattc ccgctaggtt ctccggcagc ggcagcggaa ccgatttcac tttaaccatc     1620

agctctttag agcccgagga cttcgccgtc tacttctgcc aacagagcaa tagctggcct     1680

cacacattcg gccaaggtac aaaggtcgag atcaaaggtg gaggtggcag cggtggcggc     1740

ggcagcggtg gtggtggaag cggaggcgga ggctccgagg tgaagctcgt ggaatctggc     1800

ggaggtttag tgcagcccgg tggctcttta aggctgagct gtgctgccag cggctttgcc     1860

tttagctcct acgacatgag ctgggtgcgt caagctcccg gaaagaggct ggagtgggtg     1920

gccacaatct ccggcggtgg tcgttatacc tattaccccg acaccgtcaa aggccggttt     1980

accatcagcc gggacaacgc taagaacagc cattacctcc agatgaattc tttacgggct     2040

gaggacaccg ctgtgtattt ctgtgctagc ccctacggcg gctactttga tgtctgggga     2100

caaggtaccc tcgtgaccgt gagctcc                                         2127


<210>  23
<211>  642
<212>  DNA
<213>  Composite

<400>  23
gacatccaga tgacacagag cccctcctct ttatccgctt ccgtgggaga tcgtgtcacc       60

atcacttgtc gtgcctccca agatgtgaac accgctgtgg cttggtacca gcagaagccc      120

ggtaaggctc ccaagctgct gatctactcc gccagctttt tatactccgg cgtgccctct      180

cgtttctccg gatctcgttc cggcaccgac ttcactttaa ccatcagctc tttacagccc      240

gaggacttcg ccacctacta ctgccagcag cactacacca ccccccctac cttcggacaa      300

ggtaccaagg tggagatcaa gaggaccgtg gccgccccct ccgtcttcat ctttccccct      360

tccgacgagc agctgaagtc cggcacagcc tccgtggtgt gtttactgaa taacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gataacgctt tacagtccgg caacagccaa      480

gaaagcgtga ccgaacaaga tagcaaggac tccacctact ctttatcctc cactttaact      540

ttaagcaagg ccgactacga gaagcataag gtgtacgctt gtgaggtgac ccatcaaggt      600

ttaagcagcc ccgtgaccaa gtccttcaac cggggcgaat gc                         642


<210>  24
<211>  244
<212>  PRT
<213>  Composite

<400>  24

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser His Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Asn Phe Leu His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Ser Asn Ser Trp Pro His Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  25
<211>  709
<212>  PRT
<213>  Composite

<400>  25

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser His Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Asn Phe Leu His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Ser Asn Ser Trp Pro His Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        275                 280                 285             


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        355                 360                 365             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    370                 375                 380                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
385                 390                 395                 400 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                405                 410                 415     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            420                 425                 430         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        435                 440                 445             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    450                 455                 460                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
465                 470                 475                 480 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                485                 490                 495     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            500                 505                 510         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        515                 520                 525             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    530                 535                 540                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
545                 550                 555                 560 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                565                 570                 575     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            580                 585                 590         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        595                 600                 605             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    610                 615                 620                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
625                 630                 635                 640 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                645                 650                 655     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            660                 665                 670         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        675                 680                 685             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    690                 695                 700                 


Leu Ser Pro Gly Lys 
705                 


<210>  26
<211>  2127
<212>  DNA
<213>  Composite

<400>  26
gaggtgaagc tggtggagtc cggcggcggc ctggtgcagc ctggcggctc cctgaggctg       60

tcctgcgccg cctccggctt cgccttctcc tcctacgaca tgtcctgggt gaggcaggcc      120

cctggcaaga ggctggagtg ggtggccacc atctccggcg gcggcaggta cacctactac      180

cctgacaccg tgaagggcag gttcaccatc tccagggaca acgccaagaa ctcccactac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt acttctgcgc ctccccttac      300

ggcggctact tcgacgtgtg gggccagggc accctggtga ccgtgtcctc cggcggcggc      360

ggctccggcg gcggcggctc cggcggcggc ggctccggcg gcggcggctc cgagatcgtg      420

ctgacccagt cccctgccac cctgtccctg tcccctggcg agagggccac cctgtcctgc      480

agggcctccc agtccatctc caacttcctg cactggtacc agcagaagcc tggccaggcc      540

cctaggctgc tgatcaagta cgcctcccag tccatctccg gcatccctgc caggttctcc      600

ggctccggct ccggcaccga cttcaccctg accatctcct ccctggagcc tgaggacttc      660

gccgtgtact tctgccagca gtccaactcc tggcctcaca ccttcggcca gggcaccaag      720

gtggagatca agggcggcgg cggctccggc ggcggcggct ccggcggcgg cggctccgag      780

gtccaactgg tggagtccgg aggaggactg gtgcaacccg gcggatccct ccggctgtct      840

tgtgctgcta gcggctttaa catcaaggat acctatatcc attgggttag gcaagctccc      900

ggtaagggct tagaatgggt cgctaggatc taccccacca atggctatac tcgttacgcc      960

gacagcgtga agggtcggtt caccatctcc gctgacacct ccaagaacac agcttacctc     1020

caaatgaact ctttacgggc cgaggacaca gccgtgtact actgttcccg gtggggaggc     1080

gacggcttct atgctatgga ttactggggc caaggtactt tagtgacagt gtccagcgcc     1140

agcacaaaag gaccttccgt cttccctctg gctccctcct ccaagagcac cagcggcgga     1200

acagctgctc tcggctgtct ggtgaaggac tacttccccg aacccgttac cgtgtcttgg     1260

aattccggcg ctttaacctc cggcgtgcac acctttcccg ctgttttaca gagcagcggc     1320

ctctattctt taagctccgt ggtcacagtg ccttcctcct ccctgggcac ccagacctac     1380

atctgcaacg tgaaccacaa gccttccaac accaaggtgg acaagaaggt ggagcctaag     1440

tcctgcgaca agacccacac ctgccctcct tgccctgccc ctgagctgct gggcggccct     1500

tccgtgttcc tgttccctcc taagcctaag gacaccctga tgatctccag gacccctgag     1560

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aggtgaagtt caactggtac     1620

gtggacggcg tggaggtgca caacgccaag accaagccta gggaggagca gtacaactcc     1680

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag     1740

tacaagtgca aggtgtccaa caaggccctg cctgccccta tcgagaagac catctccaag     1800

gccaagggcc agcctaggga gcctcaggtg tacaccctgc ctccttccag ggaggagatg     1860

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctacccttc cgacatcgcc     1920

gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg     1980

gactccgacg gctccttctt cctgtactcc aagctgaccg tggacaagtc caggtggcag     2040

cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     2100

aagtccctgt ccctgtcccc tggcaag                                         2127


