                         SEQUENCE LISTING

<110>  ϺĿҽҩƼ޹˾
 
<120>  һD-øͻ弰Ӧ

<130>  P19404372CF

<150>  CN201811408085.1
<151>  2018-11-23

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  PRT
<213>  Rhodotorula sp. JG-1b

<400>  1

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Phe Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  2
<211>  1116
<212>  DNA
<213>  Rhodotorula sp. JG-1b

<400>  2
atgacccaga acaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttgcgct       60

ctggctctgg ctcagaaagg ttacaaagtt cacgttgttg ctcgtgacct gccggaagac      120

accgttgctc agaccttcgc ttctccgtgg gctggtgcta actggacccc gttcatgtct      180

aaagaagctg gtccgcgtca ggctaaatgg gaagaagcta ccttcaaaca gtgggttgac      240

ttcgttccgc agggtctggc tatgtggctg aaaggtaccc gtcgtttcgc tgaaaccgaa      300

gctgacctgc tgggtcactg gtacaaagac atcgttccga actaccgtca cctgaacccg      360

tctgactgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt taacgctccg      420

aaattctgcc agtacctgca gcgtgaagct cagaaactgg gtgttacctt cgaacgtcgt      480

ctggttacct ctctggaaca gatcgctgac ggtgctgacc tgatcgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtgttgaa gaccaggaag ttgaaccgat ccgtggtcag      600

accgttctga tcaaatctaa ctgcaaacgt tgcaccatgg actcttctga cccgaaatct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacctggtt      720

ggtaactacg acctgtctgt tgacccggct accatcccgc gtatcctgaa acactgcctg      780

cgtctggacc cgtctatctc taccgacggt accctggaag gtatcgaaat cctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaactgga acgtgtttct      900

ttcccgctga aacgtggtca gtctctgctg gctctgggta ccgctaaagc tgctgaaggt      960

aaagcttctc gtaccgttcc ggttgttcac gcttacggtt tctcttctgc tggttaccag     1020

cagggttggg gtgctgctct ggaagttcgt gacctggttg accaggctat cggttcttct     1080

tcttctgctt cttctggtcg ttacctggct aaactg                               1116


<210>  3
<211>  368
<212>  PRT
<213>  Rhodosporidium toruloides

<400>  3

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Phe Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  4
<211>  1104
<212>  DNA
<213>  Rhodosporidium toruloides

<400>  4
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgcta actggacccc gttcatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt tgcaccatgg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  5
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N2DAAO(N54V-F58Q-M213S)

<400>  5

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  6
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N2DAAO(N54V-F58Q-M213S)

<400>  6
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc tgtaccagcg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  7
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213T

<400>  7

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ser Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  8
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213T

<400>  8
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc agtaccacgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  9
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213T

<400>  9

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  10
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213T

<400>  10
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gcgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  11
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213F

<400>  11

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Gly Thr Phe Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  12
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213F

<400>  12
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ggtacctttg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  13
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211M-M213R

<400>  13

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Met Thr Arg Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  14
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211M-M213R

<400>  14
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc acgacccatg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  15
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213T

<400>  15

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Gly Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  16
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213T

<400>  16
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gggaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  17
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213R

<400>  17

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Arg Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  18
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213R

<400>  18
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gctacccgag acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  19
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213S

<400>  19

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Gly Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  20
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213S

<400>  20
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gggacctcgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  21
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211D-M213V

<400>  21

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Asp Thr Val Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  22
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211D-M213V

<400>  22
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gataccgtgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  23
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211L-M213T

<400>  23

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  24
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211L-M213T

<400>  24
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  25
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211A-M213C

<400>  25

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Cys Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  26
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211A-M213C

<400>  26
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gctacctgtg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  27
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211A-M213L

<400>  27

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Leu Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  28
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211A-M213L

<400>  28
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gcgacccttg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  29
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211G-M213L

<400>  29

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Gly Thr Leu Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  30
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211G-M213L

<400>  30
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gggaccattg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  31
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211M-M213S

<400>  31

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Met Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  32
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211M-M213S

<400>  32
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc atgacctctg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  33
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211A-M213S

<400>  33

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  34
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211A-M213S

<400>  34
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gcgaccagtg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  35
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211H-M213L

<400>  35

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg His Thr Leu Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  36
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q- C211H-M213L

<400>  36
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc cataccctgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  37
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213C

<400>  37

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ser Thr Cys Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  38
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213C

<400>  38
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc tcgacctgtg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  39
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211M-M213L

<400>  39

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Met Thr Leu Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  40
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211M-M213L

<400>  40
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc atgaccctgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  41
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213L

<400>  41

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ser Thr Leu Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  42
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213L

<400>  42
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc tctaccttgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  43
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211Y-M213F

<400>  43

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Tyr Thr Phe Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  44
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211Y-M213F

<400>  44
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc tatacctttg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  45
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213V

<400>  45

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ser Thr Val Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  46
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211S-M213V

<400>  46
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc tctaccgtgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  47
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211M-M213T

<400>  47

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Met Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  48
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211M-M213T

<400>  48
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc atgaccacgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  49
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213W

<400>  49

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Gly Thr Trp Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  50
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211G-M213W

<400>  50
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gggacctggg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  51
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213A

<400>  51

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Ala Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  52
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213A

<400>  52
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gcgaccgctg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  53
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213V

<400>  53

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Ala Thr Val Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  54
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V-F58Q-C211A-M213V

<400>  54
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc gcgaccgtgg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  55
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54C- T56T- F58G-C211L-M213T

<400>  55

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Cys Trp Thr Pro Gly Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  56
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54C- T56T- F58G-C211L-M213T

<400>  56
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcat gttggacccc ggggatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  57
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54S- T56T- F58H-C211L-M213T

<400>  57

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ser Trp Thr Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  58
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54S- T56T- F58H-C211L-M213T

<400>  58
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcaa gttggacccc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  59
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54G- T56T- F58K-C211L-M213T

<400>  59

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Gly Trp Thr Pro Lys Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  60
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54G- T56T- F58K-C211L-M213T

<400>  60
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag ggtggacccc gaagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  61
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58H-C211L-M213T

<400>  61

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Thr Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  62
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58H-C211L-M213T

<400>  62
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggacccc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  63
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58K-C211L-M213T

<400>  63

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Thr Pro Lys Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  64
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58K-C211L-M213T

<400>  64
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggacccc gaagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  65
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54C- T56T- F58A-C211L-M213T

<400>  65

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Cys Trp Thr Pro Ala Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  66
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54C- T56T- F58A-C211L-M213T

<400>  66
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcat gttggacccc ggcgatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  67
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58H-C211L-M213T

<400>  67
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggacccc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  68
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54G- T56T- F58A-C211L-M213T

<400>  68

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Gly Trp Thr Pro Ala Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  69
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54G- T56T- F58A-C211L-M213T

<400>  69
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag ggtggacccc ggctatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  70
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54V- T56T- F58H-C211L-M213T

<400>  70

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  71
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54V- T56T- F58H-C211L-M213T

<400>  71
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag tttggacccc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  72
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54T- T56T- F58Q-C211L-M213T

<400>  72

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Thr Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  73
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54T- T56T- F58Q-C211L-M213T

<400>  73
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcaa cttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  74
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58H-C211L-M213T

<400>  74
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggacccc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  75
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54A- T56T- F58Q-C211L-M213T

<400>  75

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  76
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  54A- T56T- F58Q-C211L-M213T

<400>  76
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggacccc gcagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  77
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58K-C211L-M213

<400>  77
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggactcc gaagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  78
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58K-C211L-M213T

<400>  78
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggacgcc gaagatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  79
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54A- T56N- F58H-C211L-M213T

<400>  79

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  80
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56N- F58H-C211L-M213T

<400>  80
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggaatcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  81
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56N- F58H-C211L-M213T

<400>  81
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggaatcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  82
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54A- T56S- F58H-C211L-M213T

<400>  82

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Ser Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  83
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56S- F58H-C211L-M213T

<400>  83
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggtcgcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  84
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56S- F58H-C211L-M213T

<400>  84
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cttggtcgcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  85
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56S- F58H-C211L-M213T

<400>  85
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggtcgcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  86
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58H-C211L-M213T

<400>  86
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggacgcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  87
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56T- F58H-C211L-M213T

<400>  87
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggactcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  88
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56S- F58H-C211L-M213T

<400>  88
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggagtcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  89
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56N- F58H-C211L-M213T

<400>  89
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggaatcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  90
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N54A- T56L- F58H-C211L-M213T

<400>  90

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Leu Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  91
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N54A- T56L- F58H-C211L-M213T

<400>  91
atgacccaga ataagcgcgt ggttgttctg ggcagtggcg ttattggtct gagctgtgct       60

ttagctttag cccagaaggg ctataaagtg catgtggttg cccgcgatct gccggaagac      120

acagtggccc agacctttgc aagcccttgg gccggtgcag cgtggcttcc gcatatgagc      180

aaagaagctg gtccgcgtca agctaaatgg gaggaagcaa ccttcaaaca gtgggtggac      240

ttcgttccgc aaggtctggc aatgtggctg aaaggtaccc gccgctttgc agaaaccgaa      300

gccgatctgc tgggccattg gtataaggac atcgtgccga attaccgcca tctgaacccg      360

agcgattgtc cgccgggcgc aattggcgtg acctacgata ctttaagcgt taacgccccg      420

aagttctgtc agtatctgca gcgcgaagca cagaaactgg gcgtgacctt cgaacgccgt      480

ttagttacct ctttagagca gattgcagat ggcgccgatc tgatcgttaa tgcaaccggt      540

ctgggcgcca aaagcatcgc cggtgtggaa gatcaagaag tggaacctat ccgcggccaa      600

acagtgctga ttaagagcaa ctgtaaacgc ctgaccactg acagtagtga cccgaaaagc      660

ccggcctaca ttattccgcg cccgggtggt gaagtgatct gtggtggtac ctatttagtg      720

ggtaactatg atttaagcgt ggatccggcc accattccgc gcattttaaa acattgtctg      780

cgtttagacc cgagtattag caccgacggc acactggaag gcatcgaaat tttacgccat      840

aacgttggtc tgcgtcccgc tcgtcgtggt ggtccgcgtg tggaattaga acgcgtgagc      900

ttcccgctga agcgcggtca gagtctgtta gctttaggca ccgccaaagc agcagaaggt      960

aaagcaagcc gtaccgtgcc ggttgttcat gcctatggct tcagcagcgc cggttaccaa     1020

caaggttggg gcgcagcttt agaagttcgt gatctggtgg accaagctat tggtagcagc     1080

agtagtgcca gtagtggccg ttatttagcc aaactg                               1116


<210>  92
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54V-F58Q-M213S)

<400>  92

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  93
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54V-F58Q-M213S)

<400>  93
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgctg tttggacccc gcagatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt tgcacctctg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  94
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-F58H)

<400>  94

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Thr Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  95
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-F58H)

<400>  95
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgctg cttggacccc gcacatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt tgcaccatgg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  96
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-56N-F58H)

<400>  96

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  97
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-56N-F58H)

<400>  97
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgctg cttggaaccc gcacatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt tgcaccatgg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  98
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rtDAAO(C211L-M213T)

<400>  98

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Phe Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  99
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rtDAAO(C211L-M213T)

<400>  99
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgcta actggacccc gttcatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt ctgaccaccg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  100
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-F58H-C211L-M213T)

<400>  100

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Thr Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  101
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-F58H-C211L-M213T)

<400>  101
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgctg cttggacccc gcacatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt ctgaccaccg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  102
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-T56N-F58H-C211L-M213T)

<400>  102

Met His Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ala Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Leu Thr Thr Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  103
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rtDAAO(N54A-T56N-F58H-C211L-M213T)

<400>  103
atgcactctc agaaacgtgt tgttgttctg ggttctggtg ttatcggtct gtcttctgct       60

ctgatcctgg ctcgtaaagg ttactctgtt cacatcctgg ctcgtgacct gccggaagac      120

gtttcttctc agaccttcgc ttctccgtgg gctggtgctg cttggaaccc gcacatgacc      180

ctgaccgacg gtccgcgtca ggctaaatgg gaagaatcta ccttcaaaaa atgggttgaa      240

ctggttccga ccggtcacgc tatgtggctg aaaggtaccc gtcgtttcgc tcagaacgaa      300

gacggtctgc tgggtcactg gtacaaagac atcaccccga actaccgtcc gctgccgtct      360

tctgaatgcc cgccgggtgc tatcggtgtt acctacgaca ccctgtctgt tcacgctccg      420

aaatactgcc agtacctggc tcgtgaactg cagaaactgg gtgctacctt cgaacgtcgt      480

accgttacct ctctggaaca ggctttcgac ggtgctgacc tggttgttaa cgctaccggt      540

ctgggtgcta aatctatcgc tggtatcgac gaccaggctg ctgaaccgat ccgtggtcag      600

accgttctgg ttaaatctcc gtgcaaacgt ctgaccaccg actcttctga cccggcttct      660

ccggcttaca tcatcccgcg tccgggtggt gaagttatct gcggtggtac ctacggtgtt      720

ggtgactggg acctgtctgt taacccggaa accgttcagc gtatcctgaa acactgcctg      780

cgtctggacc cgaccatctc ttctgacggt accatcgaag gtatcgaagt tctgcgtcac      840

aacgttggtc tgcgtccggc tcgtcgtggt ggtccgcgtg ttgaagctga acgtatcgtt      900

ctgccgctgg accgtaccaa atctccgctg tctctgggtc gtggttctgc tcgtgctgct      960

aaagaaaaag aagttaccct ggttcacgct tacggtttct cttctgctgg ttaccagcag     1020

tcttggggtg ctgctgaaga cgttgctcag ctggttgacg aagctttcca gcgttaccac     1080

ggtgctgctc gtgaatctaa actg                                            1104


<210>  104
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  211-213


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)
<223>  k is g or t

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)
<223>  k is g or t

<400>  104
agcaactgta aacgcnnkac cnnkgacagt agtgacccg                              39


<210>  105
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  211-213


<220>
<221>  misc_feature
<222>  (16)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  105
cgggtcacta ctgtcmnngg tmnngcgttt acagttgct                              39


<210>  106
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  54-56-58


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)
<223>  k is g or t

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)
<223>  k is g or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)
<223>  k is g or t

<400>  106
cccttgggcc ggtgcnnktt gnnkcccnnk gatgagcaaa gaagc                       45


<210>  107
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  54-56-58


<220>
<221>  misc_feature
<222>  (16)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  107
gcttctttgc tcatcmnngg gmnncaamnn gcaccggccc aaggg                       45


