                         SEQUENCE LISTING

<110>  uniQure biopharma B.V.
       DRK-BLUTSPENDEDIENST BADENWURTTEMBERG-HESSEN GEMEINNUTZIGE
 
<120>  Adeno-associated virus vectors for expressing FVIII mimetics and 
       uses thereof.

<130>  402692-6 WO

<140>  PCT/EP2019/081846
<141>  2019-11-19

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  415
<212>  PRT
<213>  homo sapiens

<400>  1

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  2
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  3
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt      120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt      180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac      240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat      300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc      360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga      420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga      480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga      540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac      600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca      660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg      720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa      780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt      840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt      900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa      960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa     1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc     1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc     1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat     1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa     1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa     1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc     1380

act                                                                   1383


<210>  4
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-wt propeptide sequence codon-optimized

<400>  4
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagagcaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgccattccc atgtggcaga      540

gtgtctgtga gccagaccag caagctgacc agggctgagg ctgtgttccc tgatgtggac      600

tatgtgaaca gcactgaggc tgaaaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caagtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gcagcattgt gaatgagaag      780

tggattgtga ctgctgccca ctgtgtggag actggggtga agatcactgt ggtggctggg      840

gagcacaaca ttgaggagac tgagcacact gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagggtgttc     1080

cacaagggca ggtctgccct ggtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggggac tctgggggcc cccatgtgac tgaggtggag     1260

ggcaccagct tcctgactgg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt ctccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acc                                                                   1383


<210>  5
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature FIX-FIAV

<400>  5

Tyr Asn Ser Gly Lys Phe Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Ile Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Ala Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Val Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  6
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-FIAV propeptide

<400>  6

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Phe Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Ile Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Ala Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Val Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  7
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-FIAV

<400>  7
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagagata caactctggc aagttcgagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagagcaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgccattccc atgtggcaga      540

gtgtctgtga gccagaccag caagctgacc agggctgagg ctgtgttccc tgatgtggac      600

tatgtgaaca gcactgaggc tgaaaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccaggat cgtggggggg gaggatgcca agcctggcca gttcccctgg      720

caagtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gcagcattgt gaatgagaag      780

tggattgtga ctgctgccca ctgtgtggag actggggtga agatcactgt ggtggctggg      840

gagcacaaca ttgaggagac tgagcacact gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac gcctacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagggtgttc     1080

cacaagggca ggtctgccct ggtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggggac tctgggggcc cccatgtgac tgaggtggag     1260

ggcaccagct tcctgactgg catcgtgagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt ctccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acc                                                                   1383


<210>  8
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP1 promoter

<400>  8
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc       60

tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc      120

cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt      180

agtgtgagag gggaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc      240

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt      300

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc      360

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg      420

caccaccact gacctgggac agtgaatccg gactctaagg taaatataaa atttttaagt      480

gtataatgtg ttaaactact gattctaatt gtttctctct tttagattcc aacctttgga      540

actgaattct agaccacc                                                    558


<210>  9
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  9
aagcaaatat ttgtggttat ggattaactc gaa                                    33


<210>  10
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  10
ctgtttgccc actctatttg ccc                                               23


<210>  11
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  11
ggcgcccttt ggaccttttg caatcctgg                                         29


<210>  12
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  12
agcaaacagc aaacac                                                       16


<210>  13
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  13
ggacttagcc cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc       60

agcctc                                                                  66


<210>  14
<211>  101
<212>  DNA
<213>  Homo sapiens

<400>  14
gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac tggggtgacc       60

ttggttaata ttcaccagca gcctcccccg ttgcccctct g                          101


<210>  15
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  15
gggcatataa aacaggggca aggcacagac tcatagcaga gcaatcacca ccaagcctgg       60

aataactgca gccacc                                                       76


<210>  16
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic promoter Q1 variant 2

<400>  16
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgcccggcg       60

ccctttggac cttttgcaat cctggagcaa acagcaaaca ctcactttgc ccctatttac      120

tcctccgatg actcaggtga ctttggttaa tattcaccag cagctagggg catataaaac      180

aggggcaagg cacagactca tagcagagca atcaccacca agcctggaat aactgcagcc      240

acc                                                                    243


<210>  17
<211>  278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic promoter Q1 variant 1

<400>  17
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgcccggcg       60

ccctttggac cttttgcaat cctggagcaa acagcaaaca cgactcagat cccagccagt      120

ggacttagcc cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc      180

agcctccccc gttgcccctc tggggcatat aaaacagggg caaggcacag actcatagca      240

gagcaatcac caccaagcct ggaataactg cagccacc                              278


<210>  18
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic promoter Q1

<400>  18
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgcccggcg       60

ccctttggac cttttgcaat cctggagcaa acagcaaaca cggacttagc ccctgtttgc      120

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcggg catataaaac      180

aggggcaagg cacagactca tagcagagca atcaccacca agcctggaat aactgcagcc      240

acc                                                                    243


<210>  19
<211>  2111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP1 FIX cassette FIAV

<400>  19
cccctaaaat gggcaaacat tgcaagcagc aaacagcaaa cacacagccc tccctgcctg       60

ctgaccttgg agctggggca gaggtcagag acctctctgg gcccatgcca cctccaacat      120

ccactcgacc ccttggaatt tcggtggaga ggagcagagg ttgtcctggc gtggtttagg      180

tagtgtgaga ggggaatgac tcctttcggt aagtgcagtg gaagctgtac actgcccagg      240

caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac ttagcccctg      300

tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc tcccccgttg      360

cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc tcagcttcag      420

gcaccaccac tgacctggga cagtgaatcc ggactctaag gtaaatataa aatttttaag      480

tgtataatgt gttaaactac tgattctaat tgtttctctc ttttagattc caacctttgg      540

aactgaacta gtattctaga ccaccgctag catgcagagg gtgaacatga tcatggctga      600

gagccctggc ctgatcacca tctgcctgct gggctacctg ctgtctgctg agtgcactgt      660

gttcctggac catgagaatg ccaacaagat cctgaacagg cccaagagat acaactctgg      720

caagttcgag gagtttgtgc agggcaacct ggagagggag tgcatggagg agaagtgcag      780

ctttgaggag gccagggagg tgtttgagaa cactgagagg accactgagt tctggaagca      840

gtatgtggat ggggaccagt gtgagagcaa cccctgcctg aatgggggca gctgcaagga      900

tgacatcaac agctatgagt gctggtgccc ctttggcttt gagggcaaga actgtgagct      960

ggatgtgacc tgcaacatca agaatggcag atgtgagcag ttctgcaaga actctgctga     1020

caacaaggtg gtgtgcagct gcactgaggg ctacaggctg gctgagaacc agaagagctg     1080

tgagcctgct gtgccattcc catgtggcag agtgtctgtg agccagacca gcaagctgac     1140

cagggctgag gctgtgttcc ctgatgtgga ctatgtgaac agcactgagg ctgaaaccat     1200

cctggacaac atcacccaga gcacccagag cttcaatgac ttcaccagga tcgtgggggg     1260

ggaggatgcc aagcctggcc agttcccctg gcaagtggtg ctgaatggca aggtggatgc     1320

cttctgtggg ggcagcattg tgaatgagaa gtggattgtg actgctgccc actgtgtgga     1380

gactggggtg aagatcactg tggtggctgg ggagcacaac attgaggaga ctgagcacac     1440

tgagcagaag aggaatgtga tcaggatcat cccccaccac aactacaatg ctgccatcaa     1500

cgcctacaac catgacattg ccctgctgga gctggatgag cccctggtgc tgaacagcta     1560

tgtgaccccc atctgcattg ctgacaagga gtacaccaac atcttcctga agtttggctc     1620

tggctatgtg tctggctggg gcagggtgtt ccacaagggc aggtctgccc tggtgctgca     1680

gtacctgagg gtgcccctgg tggacagggc cacctgcctg aggagcacca agttcaccat     1740

ctacaacaac atgttctgtg ctggcttcca tgaggggggc agggacagct gccaggggga     1800

ctctgggggc ccccatgtga ctgaggtgga gggcaccagc ttcctgactg gcatcgtgag     1860

ctggggggag gagtgtgcca tgaagggcaa gtatggcatc tacaccaaag tctccagata     1920

tgtgaactgg atcaaggaga agaccaagct gacctgagcg gccgcctcga gcgatcgctg     1980

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     2040

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     2100

ggttttttaa a                                                          2111


<210>  20
<211>  1783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Q1 variant 2 - FIAV - cassette

<400>  20
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgcccggcg       60

ccctttggac cttttgcaat cctggagcaa acagcaaaca ctcactttgc ccctatttac      120

tcctccgatg actcaggtga ctttggttaa tattcaccag cagctagggg catataaaac      180

aggggcaagg cacagactca tagcagagca atcaccacca agcctggaat aactgcagcc      240

accatgcaga gggtgaacat gatcatggct gagagccctg gcctgatcac catctgcctg      300

ctgggctacc tgctgtctgc tgagtgcact gtgttcctgg accatgagaa tgccaacaag      360

atcctgaaca ggcccaagag atacaactct ggcaagttcg aggagtttgt gcagggcaac      420

ctggagaggg agtgcatgga ggagaagtgc agctttgagg aggccaggga ggtgtttgag      480

aacactgaga ggaccactga gttctggaag cagtatgtgg atggggacca gtgtgagagc      540

aacccctgcc tgaatggggg cagctgcaag gatgacatca acagctatga gtgctggtgc      600

ccctttggct ttgagggcaa gaactgtgag ctggatgtga cctgcaacat caagaatggc      660

agatgtgagc agttctgcaa gaactctgct gacaacaagg tggtgtgcag ctgcactgag      720

ggctacaggc tggctgagaa ccagaagagc tgtgagcctg ctgtgccatt cccatgtggc      780

agagtgtctg tgagccagac cagcaagctg accagggctg aggctgtgtt ccctgatgtg      840

gactatgtga acagcactga ggctgaaacc atcctggaca acatcaccca gagcacccag      900

agcttcaatg acttcaccag gatcgtgggg ggggaggatg ccaagcctgg ccagttcccc      960

tggcaagtgg tgctgaatgg caaggtggat gccttctgtg ggggcagcat tgtgaatgag     1020

aagtggattg tgactgctgc ccactgtgtg gagactgggg tgaagatcac tgtggtggct     1080

ggggagcaca acattgagga gactgagcac actgagcaga agaggaatgt gatcaggatc     1140

atcccccacc acaactacaa tgctgccatc aacgcctaca accatgacat tgccctgctg     1200

gagctggatg agcccctggt gctgaacagc tatgtgaccc ccatctgcat tgctgacaag     1260

gagtacacca acatcttcct gaagtttggc tctggctatg tgtctggctg gggcagggtg     1320

ttccacaagg gcaggtctgc cctggtgctg cagtacctga gggtgcccct ggtggacagg     1380

gccacctgcc tgaggagcac caagttcacc atctacaaca acatgttctg tgctggcttc     1440

catgaggggg gcagggacag ctgccagggg gactctgggg gcccccatgt gactgaggtg     1500

gagggcacca gcttcctgac tggcatcgtg agctgggggg aggagtgtgc catgaagggc     1560

aagtatggca tctacaccaa agtctccaga tatgtgaact ggatcaagga gaagaccaag     1620

ctgacctgag cggccgcctc gagcgatcgc tgctttattt gtgaaatttg tgatgctatt     1680

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat     1740

tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaa                       1783


<210>  21
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Q1 variant 1 - FIAV - cassette

<400>  21
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgcccggcg       60

ccctttggac cttttgcaat cctggagcaa acagcaaaca cgactcagat cccagccagt      120

ggacttagcc cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc      180

agcctccccc gttgcccctc tggggcatat aaaacagggg caaggcacag actcatagca      240

gagcaatcac caccaagcct ggaataactg cagccaccat gcagagggtg aacatgatca      300

tggctgagag ccctggcctg atcaccatct gcctgctggg ctacctgctg tctgctgagt      360

gcactgtgtt cctggaccat gagaatgcca acaagatcct gaacaggccc aagagataca      420

actctggcaa gttcgaggag tttgtgcagg gcaacctgga gagggagtgc atggaggaga      480

agtgcagctt tgaggaggcc agggaggtgt ttgagaacac tgagaggacc actgagttct      540

ggaagcagta tgtggatggg gaccagtgtg agagcaaccc ctgcctgaat gggggcagct      600

gcaaggatga catcaacagc tatgagtgct ggtgcccctt tggctttgag ggcaagaact      660

gtgagctgga tgtgacctgc aacatcaaga atggcagatg tgagcagttc tgcaagaact      720

ctgctgacaa caaggtggtg tgcagctgca ctgagggcta caggctggct gagaaccaga      780

agagctgtga gcctgctgtg ccattcccat gtggcagagt gtctgtgagc cagaccagca      840

agctgaccag ggctgaggct gtgttccctg atgtggacta tgtgaacagc actgaggctg      900

aaaccatcct ggacaacatc acccagagca cccagagctt caatgacttc accaggatcg      960

tgggggggga ggatgccaag cctggccagt tcccctggca agtggtgctg aatggcaagg     1020

tggatgcctt ctgtgggggc agcattgtga atgagaagtg gattgtgact gctgcccact     1080

gtgtggagac tggggtgaag atcactgtgg tggctgggga gcacaacatt gaggagactg     1140

agcacactga gcagaagagg aatgtgatca ggatcatccc ccaccacaac tacaatgctg     1200

ccatcaacgc ctacaaccat gacattgccc tgctggagct ggatgagccc ctggtgctga     1260

acagctatgt gacccccatc tgcattgctg acaaggagta caccaacatc ttcctgaagt     1320

ttggctctgg ctatgtgtct ggctggggca gggtgttcca caagggcagg tctgccctgg     1380

tgctgcagta cctgagggtg cccctggtgg acagggccac ctgcctgagg agcaccaagt     1440

tcaccatcta caacaacatg ttctgtgctg gcttccatga ggggggcagg gacagctgcc     1500

agggggactc tgggggcccc catgtgactg aggtggaggg caccagcttc ctgactggca     1560

tcgtgagctg gggggaggag tgtgccatga agggcaagta tggcatctac accaaagtct     1620

ccagatatgt gaactggatc aaggagaaga ccaagctgac ctgagcggcc gcctcgagcg     1680

atcgctgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     1740

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg     1800

tgtgggaggt tttttaaa                                                   1818


<210>  22
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Q1 cassette

<400>  22
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgcccggcg       60

ccctttggac cttttgcaat cctggagcaa acagcaaaca cggacttagc ccctgtttgc      120

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcggg catataaaac      180

aggggcaagg cacagactca tagcagagca atcaccacca agcctggaat aactgcagcc      240

accatgcaga gggtgaacat gatcatggct gagagccctg gcctgatcac catctgcctg      300

ctgggctacc tgctgtctgc tgagtgcact gtgttcctgg accatgagaa tgccaacaag      360

atcctgaaca ggcccaagag atacaactct ggcaagttcg aggagtttgt gcagggcaac      420

ctggagaggg agtgcatgga ggagaagtgc agctttgagg aggccaggga ggtgtttgag      480

aacactgaga ggaccactga gttctggaag cagtatgtgg atggggacca gtgtgagagc      540

aacccctgcc tgaatggggg cagctgcaag gatgacatca acagctatga gtgctggtgc      600

ccctttggct ttgagggcaa gaactgtgag ctggatgtga cctgcaacat caagaatggc      660

agatgtgagc agttctgcaa gaactctgct gacaacaagg tggtgtgcag ctgcactgag      720

ggctacaggc tggctgagaa ccagaagagc tgtgagcctg ctgtgccatt cccatgtggc      780

agagtgtctg tgagccagac cagcaagctg accagggctg aggctgtgtt ccctgatgtg      840

gactatgtga acagcactga ggctgaaacc atcctggaca acatcaccca gagcacccag      900

agcttcaatg acttcaccag gatcgtgggg ggggaggatg ccaagcctgg ccagttcccc      960

tggcaagtgg tgctgaatgg caaggtggat gccttctgtg ggggcagcat tgtgaatgag     1020

aagtggattg tgactgctgc ccactgtgtg gagactgggg tgaagatcac tgtggtggct     1080

ggggagcaca acattgagga gactgagcac actgagcaga agaggaatgt gatcaggatc     1140

atcccccacc acaactacaa tgctgccatc aacgcctaca accatgacat tgccctgctg     1200

gagctggatg agcccctggt gctgaacagc tatgtgaccc ccatctgcat tgctgacaag     1260

gagtacacca acatcttcct gaagtttggc tctggctatg tgtctggctg gggcagggtg     1320

ttccacaagg gcaggtctgc cctggtgctg cagtacctga gggtgcccct ggtggacagg     1380

gccacctgcc tgaggagcac caagttcacc atctacaaca acatgttctg tgctggcttc     1440

catgaggggg gcagggacag ctgccagggg gactctgggg gcccccatgt gactgaggtg     1500

gagggcacca gcttcctgac tggcatcgtg agctgggggg aggagtgtgc catgaagggc     1560

aagtatggca tctacaccaa agtctccaga tatgtgaact ggatcaagga gaagaccaag     1620

ctgacctgac tcgatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     1680

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     1740

agggggaggt gtgggaggtt ttttaaa                                         1767


<210>  23
<211>  724
<212>  PRT
<213>  AAV5 capsid sequence

<400>  23

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  24
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV5 capsid sequence with insertion

<400>  24

Met Ala Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly 
1               5                   10                  15      


Glu Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro 
    690                 695                 700                 


Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Pro Leu 
                725 


<210>  25
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV5 hybrid capsid sequence

<400>  25

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro 
    690                 695                 700                 


Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Pro Leu 
                725 


<210>  26
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX IDAV mature protein

<400>  26

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Ile Val Gly Gly Asp Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Ala Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Val Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  27
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  propeptide FIX IDAV

<400>  27

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Ile Val Gly Gly Asp Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Ala Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Val Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  28
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-IDAV sequence

<400>  28
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagagcaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgccattccc atgtggcaga      540

gtgtctgtga gccagaccag caagctgacc agggctgagg ctgtgttccc tgatgtggac      600

tatgtgaaca gcactgaggc tgaaaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccaggat cgtggggggg gacgatgcca agcctggcca gttcccctgg      720

caagtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gcagcattgt gaatgagaag      780

tggattgtga ctgctgccca ctgtgtggag actggggtga agatcactgt ggtggctggg      840

gagcacaaca ttgaggagac tgagcacact gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac gcctacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagggtgttc     1080

cacaagggca ggtctgccct ggtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggggac tctgggggcc cccatgtgac tgaggtggag     1260

ggcaccagct tcctgactgg catcgtgagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt ctccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acc                                                                   1383


<210>  29
<211>  2159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector genome sequence

<400>  29
gatccttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg       60

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg      120

gagtggccaa ctccatcact aggggttcct ggaggggtgg agtcgtgacg tgaattacgt      180

catagggtta gggaggtcag atctaagcaa atatttgtgg ttatggatta actcgaactg      240

tttgcccact ctatttgccc ggcgcccttt ggaccttttg caatcctgga gcaaacagca      300

aacacggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca      360

ccagcagcct cgggcatata aaacaggggc aaggcacaga ctcatagcag agcaatcacc      420

accaagcctg gaataactgc agccaccatg cagagggtga acatgatcat ggctgagagc      480

cctggcctga tcaccatctg cctgctgggc tacctgctgt ctgctgagtg cactgtgttc      540

ctggaccatg agaatgccaa caagatcctg aacaggccca agagatacaa ctctggcaag      600

ttcgaggagt ttgtgcaggg caacctggag agggagtgca tggaggagaa gtgcagcttt      660

gaggaggcca gggaggtgtt tgagaacact gagaggacca ctgagttctg gaagcagtat      720

gtggatgggg accagtgtga gagcaacccc tgcctgaatg ggggcagctg caaggatgac      780

atcaacagct atgagtgctg gtgccccttt ggctttgagg gcaagaactg tgagctggat      840

gtgacctgca acatcaagaa tggcagatgt gagcagttct gcaagaactc tgctgacaac      900

aaggtggtgt gcagctgcac tgagggctac aggctggctg agaaccagaa gagctgtgag      960

cctgctgtgc cattcccatg tggcagagtg tctgtgagcc agaccagcaa gctgaccagg     1020

gctgaggctg tgttccctga tgtggactat gtgaacagca ctgaggctga aaccatcctg     1080

gacaacatca cccagagcac ccagagcttc aatgacttca ccaggatcgt ggggggggag     1140

gatgccaagc ctggccagtt cccctggcaa gtggtgctga atggcaaggt ggatgccttc     1200

tgtgggggca gcattgtgaa tgagaagtgg attgtgactg ctgcccactg tgtggagact     1260

ggggtgaaga tcactgtggt ggctggggag cacaacattg aggagactga gcacactgag     1320

cagaagagga atgtgatcag gatcatcccc caccacaact acaatgctgc catcaacgcc     1380

tacaaccatg acattgccct gctggagctg gatgagcccc tggtgctgaa cagctatgtg     1440

acccccatct gcattgctga caaggagtac accaacatct tcctgaagtt tggctctggc     1500

tatgtgtctg gctggggcag ggtgttccac aagggcaggt ctgccctggt gctgcagtac     1560

ctgagggtgc ccctggtgga cagggccacc tgcctgagga gcaccaagtt caccatctac     1620

aacaacatgt tctgtgctgg cttccatgag gggggcaggg acagctgcca gggggactct     1680

gggggccccc atgtgactga ggtggagggc accagcttcc tgactggcat cgtgagctgg     1740

ggggaggagt gtgccatgaa gggcaagtat ggcatctaca ccaaagtctc cagatatgtg     1800

aactggatca aggagaagac caagctgacc tgactcgatg ctttatttgt gaaatttgtg     1860

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     1920

gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa aagatctgta     1980

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     2040

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     2100

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      2159


<210>  30
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant sequence

<400>  30
tcactttgcc cctatttact cctccgatga ctcaggtgac tttggttaat attcaccagc       60

agctag                                                                  66


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant a

<400>  31
gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc a                51


<210>  32
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant b

<400>  32
taacttagcc cctgtttgct cctccgatcc ccatggtgac cttggttaat attcaccagc       60

agcctc                                                                  66


<210>  33
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant c

<400>  33
agacttagcc cctgtttgct cctccgatgg ctaaggtgac cttggttaat attcaccagc       60

agctag                                                                  66


<210>  34
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant d

<400>  34
taacttagcc cctgtttgct ccttagatcc ccatggtgac cttggttaat attcaccagc       60

aatctc                                                                  66


<210>  35
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant e

<400>  35
ggacttagcc cctatttact cctccgatga ctcaggtgac tttggttaat attcaccagc       60

agcctc                                                                  66


<210>  36
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant e.

<400>  36
ggacttagcc cctgtttgct cctccgatag acggtgtgac cttggttaat attcaccata       60

gagctc                                                                  66


<210>  37
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant f

<400>  37
taacttagcc cctatttact ccttagatcc ccatggtgac tttggttaat attcaccagc       60

aatctc                                                                  66


<210>  38
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant g

<400>  38
gcggaggagc aaacaggggc taagtcataa ctggggtgac cttggttaat attcaccagc       60

agcctc                                                                  66


<210>  39
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant h

<400>  39
ggacttagcc cctgtttgct cctccgataa ctgggggctg ctggtgaata ttaaccaagg       60

tcactc                                                                  66


<210>  40
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant i

<400>  40
ggacttagcg gagcaaacag ggtccgataa ctggggtgac cttggttaat attcaccagc       60

agcctc                                                                  66


<210>  41
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant j

<400>  41
ggacttagcc cctgtttgct cctccgataa ctggggtgac ctgctggtga atattaacca       60

agcctc                                                                  66


<210>  42
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant k

<400>  42
ggacttagcc cctgtttgct cctccgcccc agttattgac cttggttaat attcaccagc       60

agcctc                                                                  66


<210>  43
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant l

<400>  43
ggacttagcc cctgtttgct cctccgtgac cttggttaat attcaccagc agcctc           56


