                         SEQUENCE LISTING

<110>  University of Copenhagen
 
<120>  Modulators of free fatty acid receptor 1 and their use for 
       treatment of diseases

<130>  P5096EP00

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  280
<212>  PRT
<213>  Homo sapiens

<300>
<301>  Srivastava et al
<302>  High-resolution structure of the human GPR40 receptor bound to 
       allosteric agonist TAK-875
<303>  Nature
<304>  513
<306>  124-127
<307>  2014-09-04

<400>  1

Met Asp Leu Pro Pro Gln Leu Ser Phe Gly Leu Tyr Val Ala Ala Phe 
1               5                   10                  15      


Ala Leu Gly Phe Pro Leu Asn Val Leu Ala Ile Arg Gly Ala Thr Ala 
            20                  25                  30          


His Ala Arg Leu Arg Leu Thr Pro Ser Ala Val Tyr Ala Leu Asn Leu 
        35                  40                  45              


Gly Cys Ser Asp Leu Leu Leu Thr Val Ser Leu Pro Leu Lys Ala Val 
    50                  55                  60                  


Glu Ala Leu Ala Ser Gly Ala Trp Pro Leu Pro Ala Ser Leu Cys Pro 
65                  70                  75                  80  


Val Phe Ala Val Ala His Phe Ala Pro Leu Tyr Ala Gly Gly Gly Phe 
                85                  90                  95      


Leu Ala Ala Leu Ser Ala Ala Arg Tyr Leu Gly Ala Ala Phe Pro Leu 
            100                 105                 110         


Gly Tyr Gln Ala Phe Arg Arg Pro Cys Tyr Ser Trp Gly Val Cys Ala 
        115                 120                 125             


Ala Ile Trp Ala Leu Val Leu Cys His Leu Gly Leu Val Phe Gly Leu 
    130                 135                 140                 


Glu Ala Pro Gly Gly Trp Leu Asp His Ser Asn Thr Ser Leu Gly Ile 
145                 150                 155                 160 


Asn Thr Pro Val Asn Gly Ser Pro Val Cys Leu Glu Ala Trp Asp Pro 
                165                 170                 175     


Ala Ser Ala Gly Pro Ala Arg Phe Ser Leu Ser Leu Leu Leu Phe Phe 
            180                 185                 190         


Leu Pro Leu Ala Ile Thr Ala Phe Cys Phe Val Gly Cys Leu Arg Ala 
        195                 200                 205             


Leu Ala Arg Ser Gly Leu Thr His Arg Arg Lys Leu Arg Ala Ala Trp 
    210                 215                 220                 


Val Ala Gly Gly Ala Leu Leu Thr Leu Leu Leu Cys Val Gly Pro Tyr 
225                 230                 235                 240 


Asn Ala Ser Asn Val Ala Ser Phe Leu Tyr Pro Asn Leu Gly Gly Ser 
                245                 250                 255     


Trp Arg Lys Leu Gly Leu Ile Thr Gly Ala Trp Ser Val Val Leu Asn 
            260                 265                 270         


Pro Leu Val Thr Gly Tyr Leu Gly 
        275                 280 


<210>  2
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Leu Pro Pro Gln Leu Ser Phe Gly Leu Tyr Val Ala Ala Phe 
1               5                   10                  15      


Ala Leu Gly Phe Pro Leu Asn Val Leu Ala Ile Arg Gly Ala Thr Ala 
            20                  25                  30          


His Ala Arg Leu Arg Leu Thr Pro Ser Leu Val Tyr Ala Leu Asn Leu 
        35                  40                  45              


Gly Cys Ser Asp Leu Leu Leu Thr Val Ser Leu Pro Leu Lys Ala Val 
    50                  55                  60                  


Glu Ala Leu Ala Ser Gly Ala Trp Pro Leu Pro Ala Ser Leu Cys Pro 
65                  70                  75                  80  


Val Phe Ala Val Ala His Phe Phe Pro Leu Tyr Ala Gly Gly Gly Phe 
                85                  90                  95      


Leu Ala Ala Leu Ser Ala Gly Arg Tyr Leu Gly Ala Ala Phe Pro Leu 
            100                 105                 110         


Gly Tyr Gln Ala Phe Arg Arg Pro Cys Tyr Ser Trp Gly Val Cys Ala 
        115                 120                 125             


Ala Ile Trp Ala Leu Val Leu Cys His Leu Gly Leu Val Phe Gly Leu 
    130                 135                 140                 


Glu Ala Pro Gly Gly Trp Leu Asp His Ser Asn Thr Ser Leu Gly Ile 
145                 150                 155                 160 


Asn Thr Pro Val Asn Gly Ser Pro Val Cys Leu Glu Ala Trp Asp Pro 
                165                 170                 175     


Ala Ser Ala Gly Pro Ala Arg Phe Ser Leu Ser Leu Leu Leu Phe Phe 
            180                 185                 190         


Leu Pro Leu Ala Ile Thr Ala Phe Cys Tyr Val Gly Cys Leu Arg Ala 
        195                 200                 205             


Leu Ala Arg Ser Gly Leu Thr His Arg Arg Lys Leu Arg Ala Ala Trp 
    210                 215                 220                 


Val Ala Gly Gly Ala Leu Leu Thr Leu Leu Leu Cys Val Gly Pro Tyr 
225                 230                 235                 240 


Asn Ala Ser Asn Val Ala Ser Phe Leu Tyr Pro Asn Leu Gly Gly Ser 
                245                 250                 255     


Trp Arg Lys Leu Gly Leu Ile Thr Gly Ala Trp Ser Val Val Leu Asn 
            260                 265                 270         


Pro Leu Val Thr Gly Tyr Leu Gly Arg Gly Pro Gly Leu Lys Thr Val 
        275                 280                 285             


Cys Ala Ala Arg Thr Gln Gly Gly Lys Ser Gln Lys 
    290                 295                 300 


