                         SEQUENCE LISTING

<110>  Technische Universitt Dresden
 
<120>  Artificial HLA-positive Feeder Cell Lines for NK cells and uses 
       thereof

<130>  TUD122WO

<150>  EP 18208092.9 - 1120
<151>  2018-11-23

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

Val Met Ala Pro Arg Thr Leu Leu Leu 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  2

Val Met Ala Pro Arg Thr Leu Phe Leu 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  3

Val Met Ala Pro Arg Thr Leu Ile Leu 
1               5                   


<210>  4
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinnt peptide

<400>  4

Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu Lys 
1               5                   10          


<210>  5
<211>  505
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  5

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Met Ala Pro Arg Thr Leu Ile Leu Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Ala Pro Gly Ser Gly Gly Gly Ser Ile Gln Arg 
        35                  40                  45              


Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys 
    50                  55                  60                  


Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile 
65                  70                  75                  80  


Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His 
                85                  90                  95      


Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr 
            100                 105                 110         


Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn 
        115                 120                 125             


His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
    130                 135                 140                 


Arg Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Ala Ser Gly Gly Gly Gly Ser His Ser Leu Lys Tyr Phe 
                165                 170                 175     


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
            180                 185                 190         


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
        195                 200                 205             


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
    210                 215                 220                 


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
225                 230                 235                 240 


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Cys Tyr Asn Gln Ser 
                245                 250                 255     


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
            260                 265                 270         


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
        275                 280                 285             


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
    290                 295                 300                 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
305                 310                 315                 320 


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
                325                 330                 335     


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
            340                 345                 350         


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
        355                 360                 365             


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
    370                 375                 380                 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
385                 390                 395                 400 


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
                405                 410                 415     


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
            420                 425                 430         


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
        435                 440                 445             


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
    450                 455                 460                 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
465                 470                 475                 480 


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
                485                 490                 495     


Ala Gln Gly Ser Glu Ser His Ser Leu 
            500                 505 


<210>  6
<211>  505
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  6

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Ala Pro Gly Ser Gly Gly Gly Ser Ile Gln Arg 
        35                  40                  45              


Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys 
    50                  55                  60                  


Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile 
65                  70                  75                  80  


Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His 
                85                  90                  95      


Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr 
            100                 105                 110         


Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn 
        115                 120                 125             


His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
    130                 135                 140                 


Arg Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Ala Ser Gly Gly Gly Gly Ser His Ser Leu Lys Tyr Phe 
                165                 170                 175     


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
            180                 185                 190         


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
        195                 200                 205             


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
    210                 215                 220                 


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
225                 230                 235                 240 


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Cys Tyr Asn Gln Ser 
                245                 250                 255     


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
            260                 265                 270         


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
        275                 280                 285             


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
    290                 295                 300                 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
305                 310                 315                 320 


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
                325                 330                 335     


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
            340                 345                 350         


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
        355                 360                 365             


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
    370                 375                 380                 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
385                 390                 395                 400 


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
                405                 410                 415     


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
            420                 425                 430         


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
        435                 440                 445             


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
    450                 455                 460                 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
465                 470                 475                 480 


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
                485                 490                 495     


Ala Gln Gly Ser Glu Ser His Ser Leu 
            500                 505 


<210>  7
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  7

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  8
<211>  982
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  8

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr 
            20                  25                  30          


Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser 
        35                  40                  45              


Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly 
    50                  55                  60                  


Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
65                  70                  75                  80  


Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
                85                  90                  95      


Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
            100                 105                 110         


Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
        115                 120                 125             


Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
    130                 135                 140                 


Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
145                 150                 155                 160 


Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
                165                 170                 175     


Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
            180                 185                 190         


Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
        195                 200                 205             


Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
    210                 215                 220                 


Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
225                 230                 235                 240 


Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
                245                 250                 255     


Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
            260                 265                 270         


Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
        275                 280                 285             


Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
    290                 295                 300                 


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
305                 310                 315                 320 


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
                325                 330                 335     


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
            340                 345                 350         


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
        355                 360                 365             


Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
    370                 375                 380                 


Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
385                 390                 395                 400 


Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
                405                 410                 415     


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            420                 425                 430         


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        435                 440                 445             


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    450                 455                 460                 


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
465                 470                 475                 480 


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                485                 490                 495     


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            500                 505                 510         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe 
        515                 520                 525             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    530                 535                 540                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
545                 550                 555                 560 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                565                 570                 575     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            580                 585                 590         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        595                 600                 605             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    610                 615                 620                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
625                 630                 635                 640 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                645                 650                 655     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            660                 665                 670         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        675                 680                 685             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    690                 695                 700                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
705                 710                 715                 720 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                725                 730                 735     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            740                 745                 750         


Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu 
        755                 760                 765             


Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp 
    770                 775                 780                 


Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln 
785                 790                 795                 800 


Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp 
                805                 810                 815     


Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys 
            820                 825                 830         


Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu 
        835                 840                 845             


Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr 
    850                 855                 860                 


Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val 
865                 870                 875                 880 


Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His 
                885                 890                 895     


Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys 
            900                 905                 910         


Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala 
        915                 920                 925             


Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala Gly 
    930                 935                 940                 


Ala Gly Pro Arg Arg Met Arg Pro Pro Thr Pro Gly Glu Gly Arg Gly 
945                 950                 955                 960 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Thr 
                965                 970                 975     


Ala Met Thr Glu Tyr Lys 
            980         


<210>  9
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  10
<211>  263
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  10

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Ser Gly Gly Ser Ala Cys Val Asn Glu Gln Lys Leu 
                165                 170                 175     


Ile Ser Glu Glu Asp Leu Gly Gly Ser Gln Ala Gln Ser Asp Cys Ser 
            180                 185                 190         


Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met Gly Asp 
        195                 200                 205             


Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg 
    210                 215                 220                 


Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln 
225                 230                 235                 240 


Arg Ile Thr Glu Thr Glu Ser Pro Ser Gln Glu Leu Gln Gly Gln Arg 
                245                 250                 255     


Ser Asp Val Ser Ser Asp Leu 
            260             


<210>  11
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Tyr 
                245                 250                 255     


Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            260                 265     


<210>  12
<211>  374
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant protein

<400>  12

Met Ala Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala 
1               5                   10                  15      


Asp Ala Gly Ser Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser His Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg 
    50                  55                  60                  


Leu Glu Trp Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr 
65                  70                  75                  80  


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys 
                85                  90                  95      


Asn Ala Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr 
        115                 120                 125             


Tyr Tyr Tyr Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser 
145                 150                 155                 160 


Glu Ala Arg Val Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                165                 170                 175     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            180                 185                 190         


Val Asp Asn Tyr Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser 
    210                 215                 220                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
225                 230                 235                 240 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys 
                245                 250                 255     


Gln Gln Thr Lys Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Gly Gly Gly Gly Ser Gly Tyr Thr Asp Ile Glu Met Asn 
        275                 280                 285             


Arg Leu Gly Lys Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Gly 
    290                 295                 300                 


Gly Gly His His His His His His Arg Pro Gln Gln Pro Thr Ile Pro 
305                 310                 315                 320 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
                325                 330                 335     


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
            340                 345                 350         


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
        355                 360                 365             


Ser Glu Ser His Ser Leu 
    370                 


<210>  13
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  13

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  14
<211>  262
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide)

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Gln Val Lys Leu Gln Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys Val Thr Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg Gln Thr Ser Asp 
    50                  55                  60                  


Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly Glu Lys Ala 
                165                 170                 175     


Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp Met Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile Ser Glu Gly 
        195                 200                 205             


Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Thr 
    210                 215                 220                 


Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser Glu Asp Val 
225                 230                 235                 240 


Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu Thr Phe Gly 
                245                 250                 255     


Asp Gly Thr Lys Leu Glu 
            260         


<210>  15
<211>  307
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Gln Val Lys Leu Gln Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Arg Thr 
65                  70                  75                  80  


Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile His Asn Gly Gly Gly 
                85                  90                  95      


His Thr Tyr Tyr Pro Asp Thr Ile Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ala Lys Asn Thr Leu Phe Leu Glu Met Ser Ser Leu Lys Ser 
        115                 120                 125             


Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg Arg Met Tyr Tyr Gly Asn 
    130                 135                 140                 


Ser His Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ser Val Thr Val 
145                 150                 155                 160 


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asn Ser Asp Ile Val 
            180                 185                 190         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        195                 200                 205             


Thr Ile Asn Cys Arg Thr Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
    210                 215                 220                 


Tyr Gln Leu Thr Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
225                 230                 235                 240 


Leu Lys Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Thr Asp Tyr Ser Leu Thr Ile Asn Asn Leu Glu Lys Glu Asp Phe 
            260                 265                 270         


Ala Thr Tyr Phe Cys Gln Gln Ser Lys Thr Leu Pro Trp Thr Phe Gly 
        275                 280                 285             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
    290                 295                 300                 


Ser Gly Pro 
305         


<210>  16
<211>  416
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Gln Val Lys Leu Gln Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Arg Thr 
65                  70                  75                  80  


Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile His Asn Gly Gly Gly 
                85                  90                  95      


His Thr Tyr Tyr Pro Asp Thr Ile Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ala Lys Asn Thr Leu Phe Leu Glu Met Ser Ser Leu Lys Ser 
        115                 120                 125             


Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg Arg Met Tyr Tyr Gly Asn 
    130                 135                 140                 


Ser His Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ser Val Thr Val 
145                 150                 155                 160 


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asn Ser Asp Ile Val 
            180                 185                 190         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        195                 200                 205             


Thr Ile Asn Cys Arg Thr Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
    210                 215                 220                 


Tyr Gln Leu Thr Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
225                 230                 235                 240 


Leu Lys Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Thr Asp Tyr Ser Leu Thr Ile Asn Asn Leu Glu Lys Glu Asp Phe 
            260                 265                 270         


Ala Thr Tyr Phe Cys Gln Gln Ser Lys Thr Leu Pro Trp Thr Phe Gly 
        275                 280                 285             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
    290                 295                 300                 


Ser Gly Pro Gly Gly Ser Gly Gly Ser Ala Cys Val Asn Glu Gln Lys 
305                 310                 315                 320 


Leu Ile Ser Glu Glu Asp Leu Gly Gly Ser Gln Ala Gln Ser Asp Cys 
                325                 330                 335     


Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met Gly 
            340                 345                 350         


Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu Gly 
        355                 360                 365             


Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys 
    370                 375                 380                 


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
385                 390                 395                 400 


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
                405                 410                 415     


<210>  17
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  17

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Gln Val Lys Leu Gln Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys Val Thr Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg Gln Thr Ser Asp 
    50                  55                  60                  


Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly Glu Lys Ala 
                165                 170                 175     


Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp Met Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile Ser Glu Gly 
        195                 200                 205             


Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Thr 
    210                 215                 220                 


Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser Glu Asp Val 
225                 230                 235                 240 


Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu Thr Phe Gly 
                245                 250                 255     


Asp Gly Thr Lys Leu Glu Ser Gly Gly Ser Gly Gly Ser Ala Cys Val 
            260                 265                 270         


Asn Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Ser Gln Ala 
        275                 280                 285             


Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly 
    290                 295                 300                 


Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val 
305                 310                 315                 320 


Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
                325                 330                 335     


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            340                 345                 350         


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        355                 360                 365             


Pro Tyr Tyr Lys 
    370         


<210>  18
<211>  185
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  18

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ala Ala 
            20                  25                  30          


Gly Gly Arg Gly Met Ser Gly Gly Gly Ser Lys Pro Leu Pro Glu Val 
        35                  40                  45              


Thr Asp Glu Tyr Gly Gly Gly Ser Ser Ser Ala Ser Gly Gly Thr Glu 
    50                  55                  60                  


Leu Gly Ser Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Ala Cys Val Asn Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
                85                  90                  95      


Gly Ser Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly 
            100                 105                 110         


Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile 
        115                 120                 125             


Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly 
    130                 135                 140                 


Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser 
145                 150                 155                 160 


Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu 
                165                 170                 175     


Asn Thr Gln Arg Pro Tyr Tyr Lys Gly 
            180                 185 


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  19

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


