                         SEQUENCE LISTING

<110>  QUINE Medical AB
 
<120>  Bi-Specific Conjugates

<130>  27.18.140300/02

<150>  GB 1819124.7
<151>  2018-11-23

<150>  GB 1902159.1
<151>  2019-02-15

<160>  155   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  1

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  2
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Gly Ser Arg Asn Gln Asp Trp Leu 
1               5                   


<210>  3
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UU-05 Peptide

<400>  3

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Ala 
            20                  25                  30          


Ala Ala Ala Ala Lys 
        35          


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UU-10 Peptide

<400>  4

Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Lys 
            


<210>  5
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UU-30 Peptide

<400>  5

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Val Gly Ala Leu Lys Val Pro Arg Asn Gln Asp Trp Leu 
            20                  25                  30          


Gly Val Pro Arg Gln Leu 
        35              


<210>  6
<211>  18
<212>  PRT
<213>  Clostridium tetani

<400>  6

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  7
<211>  13
<212>  PRT
<213>  Gallus gallus

<400>  7

Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu 
1               5                   10              


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UU-05 C-terminal sequence

<400>  8

Ala Ala Ala Ala Ala Lys 
1               5       


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human/murine gp100 fusion fragment

<400>  9

Ala Val Gly Ala Leu Lys Val Pro Arg Asn Gln Asp Trp Leu Gly Val 
1               5                   10                  15      


Pro Arg Gln Leu 
            20  


<210>  10
<211>  22
<212>  PRT
<213>  Clostridium tetani

<400>  10

Gly Ile Leu Phe Leu Gln Trp Val Arg Asp Ile Ile Asp Asp Phe Thr 
1               5                   10                  15      


Asn Glu Ser Ser Gln Lys 
            20          


<210>  11
<211>  21
<212>  PRT
<213>  Clostridium tetani

<400>  11

Asp Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn 
1               5                   10                  15      


Arg Ile Lys Asn Asn 
            20      


<210>  12
<211>  25
<212>  PRT
<213>  Clostridium tetani

<400>  12

Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys 
1               5                   10                  15      


Ala Ile Ala Asn Lys Leu Ser Gln Val 
            20                  25  


<210>  13
<211>  21
<212>  PRT
<213>  Clostridium tetani

<400>  13

Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His 
1               5                   10                  15      


Gly Leu Tyr Gly Met 
            20      


<210>  14
<211>  24
<212>  PRT
<213>  Clostridium tetani

<400>  14

Asp Gly Ile Leu Phe Leu Gln Trp Val Arg Asp Ile Ile Asp Asp Phe 
1               5                   10                  15      


Thr Asn Glu Ser Ser Gln Lys Arg 
            20                  


<210>  15
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 C127S constant region

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  16
<211>  1315
<212>  PRT
<213>  Clostridium tetani

<400>  16

Met Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn 
1               5                   10                  15      


Asp Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu 
        35                  40                  45              


Arg Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser 
    50                  55                  60                  


Leu Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr 
65                  70                  75                  80  


Asp Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn 
                85                  90                  95      


Arg Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile 
            100                 105                 110         


Asn Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe 
        115                 120                 125             


Asp Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro 
    130                 135                 140                 


Ser Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe 
145                 150                 155                 160 


Gly Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu 
                165                 170                 175     


Arg Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser 
            180                 185                 190         


Ile Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn 
        195                 200                 205             


Val Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe 
    210                 215                 220                 


Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His 
225                 230                 235                 240 


Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys 
                245                 250                 255     


Gln Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu 
            260                 265                 270         


Phe Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys 
        275                 280                 285             


Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn 
    290                 295                 300                 


Lys Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp 
305                 310                 315                 320 


Ser Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser 
                325                 330                 335     


Asn Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn 
            340                 345                 350         


Ser Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn 
        355                 360                 365             


Ile Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys 
    370                 375                 380                 


Ile Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe 
385                 390                 395                 400 


Asn Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met 
                405                 410                 415     


Arg Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val 
            420                 425                 430         


Ser Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile 
        435                 440                 445             


Arg Glu Asn Leu Tyr Asn Arg Thr Ala Ser Leu Thr Asp Leu Gly Gly 
    450                 455                 460                 


Glu Leu Cys Ile Lys Ile Lys Asn Glu Asp Leu Thr Phe Ile Ala Glu 
465                 470                 475                 480 


Lys Asn Ser Phe Ser Glu Glu Pro Phe Gln Asp Glu Ile Val Ser Tyr 
                485                 490                 495     


Asn Thr Lys Asn Lys Pro Leu Asn Phe Asn Tyr Ser Leu Asp Lys Ile 
            500                 505                 510         


Ile Val Asp Tyr Asn Leu Gln Ser Lys Ile Thr Leu Pro Asn Asp Arg 
        515                 520                 525             


Thr Thr Pro Val Thr Lys Gly Ile Pro Tyr Ala Pro Glu Tyr Lys Ser 
    530                 535                 540                 


Asn Ala Ala Ser Thr Ile Glu Ile His Asn Ile Asp Asp Asn Thr Ile 
545                 550                 555                 560 


Tyr Gln Tyr Leu Tyr Ala Gln Lys Ser Pro Thr Thr Leu Gln Arg Ile 
                565                 570                 575     


Thr Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile 
            580                 585                 590         


Tyr Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln 
        595                 600                 605             


Gly Ile Leu Phe Leu Gln Trp Val Arg Asp Ile Ile Asp Asp Phe Thr 
    610                 615                 620                 


Asn Glu Ser Ser Gln Lys Thr Thr Ile Asp Lys Ile Ser Asp Val Ser 
625                 630                 635                 640 


Thr Ile Val Pro Tyr Ile Gly Pro Ala Leu Asn Ile Val Lys Gln Gly 
                645                 650                 655     


Tyr Glu Gly Asn Phe Ile Gly Ala Leu Glu Thr Thr Gly Val Val Leu 
            660                 665                 670         


Leu Leu Glu Tyr Ile Pro Glu Ile Thr Leu Pro Val Ile Ala Ala Leu 
        675                 680                 685             


Ser Ile Ala Glu Ser Ser Thr Gln Lys Glu Lys Ile Ile Lys Thr Ile 
    690                 695                 700                 


Asp Asn Phe Leu Glu Lys Arg Tyr Glu Lys Trp Ile Glu Val Tyr Lys 
705                 710                 715                 720 


Leu Val Lys Ala Lys Trp Leu Gly Thr Val Asn Thr Gln Phe Gln Lys 
                725                 730                 735     


Arg Ser Tyr Gln Met Tyr Arg Ser Leu Glu Tyr Gln Val Asp Ala Ile 
            740                 745                 750         


Lys Lys Ile Ile Asp Tyr Glu Tyr Lys Ile Tyr Ser Gly Pro Asp Lys 
        755                 760                 765             


Glu Gln Ile Ala Asp Glu Ile Asn Asn Leu Lys Asn Lys Leu Glu Glu 
    770                 775                 780                 


Lys Ala Asn Lys Ala Met Ile Asn Ile Asn Ile Phe Met Arg Glu Ser 
785                 790                 795                 800 


Ser Arg Ser Phe Leu Val Asn Gln Met Ile Asn Glu Ala Lys Lys Gln 
                805                 810                 815     


Leu Leu Glu Phe Asp Thr Gln Ser Lys Asn Ile Leu Met Gln Tyr Ile 
            820                 825                 830         


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu 
        835                 840                 845             


Ser Lys Ile Asn Lys Val Phe Ser Thr Pro Ile Pro Phe Ser Tyr Ser 
    850                 855                 860                 


Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile 
865                 870                 875                 880 


Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile 
                885                 890                 895     


Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala 
            900                 905                 910         


Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn 
        915                 920                 925             


Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn 
    930                 935                 940                 


Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
945                 950                 955                 960 


Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile 
                965                 970                 975     


Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser 
            980                 985                 990         


Val Ser Leu Lys Gly Asn Asn Leu  Ile Trp Thr Leu Lys  Asp Ser Ala 
        995                 1000                 1005             


Gly Glu  Val Arg Gln Ile Thr  Phe Arg Asp Leu Pro  Asp Lys Phe 
    1010                 1015                 1020             


Asn Ala  Tyr Leu Ala Asn Lys  Trp Val Phe Ile Thr  Ile Thr Asn 
    1025                 1030                 1035             


Asp Arg  Leu Ser Ser Ala Asn  Leu Tyr Ile Asn Gly  Val Leu Met 
    1040                 1045                 1050             


Gly Ser  Ala Glu Ile Thr Gly  Leu Gly Ala Ile Arg  Glu Asp Asn 
    1055                 1060                 1065             


Asn Ile  Thr Leu Lys Leu Asp  Arg Cys Asn Asn Asn  Asn Gln Tyr 
    1070                 1075                 1080             


Val Ser  Ile Asp Lys Phe Arg  Ile Phe Cys Lys Ala  Leu Asn Pro 
    1085                 1090                 1095             


Lys Glu  Ile Glu Lys Leu Tyr  Thr Ser Tyr Leu Ser  Ile Thr Phe 
    1100                 1105                 1110             


Leu Arg  Asp Phe Trp Gly Asn  Pro Leu Arg Tyr Asp  Thr Glu Tyr 
    1115                 1120                 1125             


Tyr Leu  Ile Pro Val Ala Ser  Ser Ser Lys Asp Val  Gln Leu Lys 
    1130                 1135                 1140             


Asn Ile  Thr Asp Tyr Met Tyr  Leu Thr Asn Ala Pro  Ser Tyr Thr 
    1145                 1150                 1155             


Asn Gly  Lys Leu Asn Ile Tyr  Tyr Arg Arg Leu Tyr  Asn Gly Leu 
    1160                 1165                 1170             


Lys Phe  Ile Ile Lys Arg Tyr  Thr Pro Asn Asn Glu  Ile Asp Ser 
    1175                 1180                 1185             


Phe Val  Lys Ser Gly Asp Phe  Ile Lys Leu Tyr Val  Ser Tyr Asn 
    1190                 1195                 1200             


Asn Asn  Glu His Ile Val Gly  Tyr Pro Lys Asp Gly  Asn Ala Phe 
    1205                 1210                 1215             


Asn Asn  Leu Asp Arg Ile Leu  Arg Val Gly Tyr Asn  Ala Pro Gly 
    1220                 1225                 1230             


Ile Pro  Leu Tyr Lys Lys Met  Glu Ala Val Lys Leu  Arg Asp Leu 
    1235                 1240                 1245             


Lys Thr  Tyr Ser Val Gln Leu  Lys Leu Tyr Asp Asp  Lys Asn Ala 
    1250                 1255                 1260             


Ser Leu  Gly Leu Val Gly Thr  His Asn Gly Gln Ile  Gly Asn Asp 
    1265                 1270                 1275             


Pro Asn  Arg Asp Ile Leu Ile  Ala Ser Asn Trp Tyr  Phe Asn His 
    1280                 1285                 1290             


Leu Lys  Asp Lys Ile Leu Gly  Cys Asp Trp Tyr Phe  Val Pro Thr 
    1295                 1300                 1305             


Asp Glu  Gly Trp Thr Asn Asp  
    1310                 1315 


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 VHCDR1

<400>  17

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 VHCDR2

<400>  18

Ile Gly Gly Ser Ser Ser Tyr Thr 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 VHCDR3

<400>  19

Ala Arg Tyr Tyr Ser Tyr His Met Asp Tyr 
1               5                   10  


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 VLCDR1

<400>  20

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 VLCDR2

<400>  21

Ala Ala Ser
1               


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 VLCDR3

<400>  22

Gln Gln Tyr Gly Ser Ala Pro Pro Thr 
1               5                   


<210>  23
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 Heavy Chain Variable Domain

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Gly Ser Ser Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ser Tyr His Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABS-1150 Light Chain Variable Domain

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp His Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABS-1150 Heavy Chain Variable Domain

<400>  25
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc       60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attggtggtt cttcttctta cacatcttat      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctactac      300

tcttaccata tggactattg gggccaggga accctggtca ccgtctcctc a               351


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABS-1150 Light Chain Variable Domain

<400>  26
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccacgtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttatta ctgtcaacag tacggttctg ctccgcccac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  27
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 Heavy Chain Variable Domain

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 Light Chain Variable Domain

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CP-870,893 Heavy Chain Variable Domain

<400>  29
caggtgcagc tggtgcagtc tggagctgag gtgaagaaac caggagcttc tgtgaaggtg       60

agttgcaaag cctcaggcta caccttcaca gggtactata tgcactgggt gcggcaggct      120

cctggacagg gcctggaatg gatgggctgg atcaaccctg actctggcgg gaccaattac      180

gcccagaagt ttcaggggag ggtgactatg acccgcgata ccagcatttc cacagcttat      240

atggagctga accggctgag aagcgacgat actgccgtgt actattgtgc tagggaccag      300

cccctgggat attgcaccaa tggcgtgtgc agctacttcg attattgggg gcagggaaca      360

ctggtgaccg tgagctca                                                    378


<210>  30
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CP-870,893 Light Chain Variable Domain

<400>  30
gacatccaga tgacccagtc tcctagctcc gtgtcagcct ctgtgggcga tagagtgacc       60

atcacatgca gagcctctca ggggatctac tcctggctgg cttggtatca gcagaagccc      120

ggcaaagccc ctaacctgct gatctacaca gcttcaactc tgcagtctgg agtgccctcc      180

cggttctccg gctctgggag tggaactgac tttactctga ccatttctag tctgcagcca      240

gaggatttcg ccacctacta ttgtcagcag gctaatatct tccccctgac ctttggcggg      300

ggaacaaagg tggaaattaa a                                                321


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VHCDR1 (IMGT)

<400>  31

Gly Phe Thr Phe Ser Thr Tyr Gly 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VHCDR2 (IMGT)

<400>  32

Ile Ser Gly Gly Ser Ser Tyr Ile 
1               5               


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VHCDR3 (IMGT)

<400>  33

Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu 
1               5                   10          


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VLCDR1 (IMGT)

<400>  34

Ser Ser Asn Ile Gly Ala Gly Tyr Asn 
1               5                   


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VLCDR2 (IMGT)

<400>  35

Gly Asn Ile Asn 
1               


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VLCDR3 (IMGT)

<400>  36

Ala Ala Trp Asp Lys Ser Ile Ser Gly Leu Val 
1               5                   10      


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 Heavy Chain Variable Domain

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Val Trp Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Tyr Ile Ser Gly Gly Ser Ser Tyr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 Light Chain Variable Domain

<400>  38

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Lys Ser 
                85                  90                  95      


Ile Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  39
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADC-1013 Heavy Chain Variable Domain

<400>  39
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acttatggca tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg gctttcatat attagtggtg gtagtagtta cattttctac      180

gcagactcag tgaggggccg attcaccatc tccagagaca actccgagaa cgcgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaatatta      300

agaggcggga gcggtatgga cctctggggc caaggtacac tggtcaccgt gagctca         357


<210>  40
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADC-1013 Light Chain Variable Domain

<400>  40
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgcactg ggagcagctc caacatcggg gcgggttaca atgtatactg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatggtaaca tcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgt gcagcatggg ataagagcat ttctggtctg      300

gttttcggcg gaggaaccaa gctgacggtc ctaggt                                336


<210>  41
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  42
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  43
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  44
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  45
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  45

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  46
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  47
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII scFv

<400>  47

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Asn Phe Ser Asn Leu Asn Gln Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Glu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Thr Pro Ser Val Leu 
    130                 135                 140                 


Val Thr Pro Gly Glu Ala Val Ser Ile Ser Cys Arg Ala Ser Arg Ser 
145                 150                 155                 160 


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Val 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
        195                 200                 205             


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Met Gln His Leu Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  48
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IBIIICI-b scFv

<400>  48

Glu Val Arg Leu Leu Gln Ser Gly Ala Ala Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Phe 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Asp Ala Glu Tyr Val Pro Lys Phe 
    50                  55                  60                  


Gln Val Arg Ala Thr Met Thr Thr Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ser Tyr Asp Leu Asp Val Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Thr Val Thr Ile Thr 
145                 150                 155                 160 


Cys His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln 
                165                 170                 175     


Arg Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu 
            180                 185                 190         


His Thr Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Gly 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys 
                245 


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS2 Linker

<400>  49

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  50
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS linker module

<400>  51

Gly Gly Gly Gly Ser 
1               5   


<210>  52
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiLob 7/4 Heavy Chain Variable Domain

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ile Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ile Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Glu Val Tyr Gly Arg Asn Tyr Tyr Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiLob 7/4 Light Chain Variable Domain

<400>  53

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEA-CD40 Heavy Chain Variable Domain

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Val Ile Pro Asn Ala Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Tyr Trp Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  55
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEA-CD40 Light Chain Variable Domain

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  56
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M Heavy Chain Variable Domain

<400>  56

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Thr 
            20                  25                  30          


Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Thr Gly Asp Gly Thr Asn Tyr Ser Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Asp Ile Thr Tyr Gly Phe Ala Ile Asn Phe Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M Light Chain Variable Domain

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Cys Thr Gly Tyr Gly Ile Ser 
                85                  90                  95      


Trp Pro Ile Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VHCDR1 (IMGT)

<400>  58

Gly Phe Ser Phe Ser Ser Thr Tyr Val 
1               5                   


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VHCDR2 (IMGT)

<400>  59

Ile Tyr Thr Gly Asp Gly Thr Asn 
1               5               


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VHCDR3 (IMGT)

<400>  60

Ala Arg Pro Asp Ile Thr Tyr Gly Phe Ala Ile Asn Phe 
1               5                   10              


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VLCDR1 (IMGT)

<400>  61

Gln Ser Ile Ser Ser Arg 
1               5       


<210>  62
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VLCDR2 (IMGT)

<400>  62

Arg Ala Ser
1               


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VLCDR3 (IMGT)

<400>  63

Gln Cys Thr Gly Tyr Gly Ile 
1               5           


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 VHCDR1

<400>  64

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 VHCDR2

<400>  65

Ile Asn Pro Asp Ser Gly Gly Thr 
1               5               


<210>  66
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 VHCDR3

<400>  66

Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 VLCDR1

<400>  67

Gln Gly Ile Tyr Ser Trp 
1               5       


<210>  68
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 VLCDR2

<400>  68

Thr Ala Ser
1               


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-870,893 VLCDR3

<400>  69

Gln Gln Ala Asn Ile Phe Pro Leu Thr 
1               5                   


<210>  70
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FITC-8 scFv

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Asn Gly Gly Tyr Thr Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asp Gly Ser Gly Trp Ser Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  71
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide UU-44

<400>  71

Ala Gly Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln 
1               5                   10                  15      


Gly Gln Asn Leu Lys Tyr 
            20          


<210>  72
<211>  9
<212>  PRT
<213>  Human cytomegalovirus

<400>  72

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  73
<211>  37
<212>  PRT
<213>  Clostridium tetani

<400>  73

Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys 
1               5                   10                  15      


Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln Val Thr 
            20                  25                  30          


Ser Cys Asn Asp Pro 
        35          


<210>  74
<211>  37
<212>  PRT
<213>  Clostridium tetani

<400>  74

Thr Ile Gly Lys Ser Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met 
1               5                   10                  15      


His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Met Gln Val Ser 
            20                  25                  30          


Ser His Glu Ile Ile 
        35          


<210>  75
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  75

Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  76

Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  77

Asn Leu Ile Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  78

Leu Ile Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  79

Ile Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  80

Ser Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  81

Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  82

Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  83

Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  84

Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  85

Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  86

Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  87

Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  88

Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  89

Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  90

Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  91

Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln Val 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  92

Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln Val Thr 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  93

Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln Val Thr Ser 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  94

Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln Val Thr Ser Cys 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  95

Tyr Lys Ala Ile Ala Asn Lys Leu Ser Gln Val Thr Ser Cys Asn 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  96

Lys Ala Ile Ala Asn Lys Leu Ser Gln Val Thr Ser Cys Asn Asp 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  97

Ala Ile Ala Asn Lys Leu Ser Gln Val Thr Ser Cys Asn Asp Pro 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  98

Thr Ile Gly Lys Ser Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  99

Ile Gly Lys Ser Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  100

Gly Lys Ser Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met His 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  101

Lys Ser Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met His Glu 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  102

Ser Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  103

Lys Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  104

Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  105

Phe Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  106

Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  107

Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  108

Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  109

Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly Leu 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  110

Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  111

Leu Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  112

Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Met 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  113

Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Met Gln 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  114

His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Met Gln Val 
1               5                   10                  15  


<210>  115
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  115

Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Met Gln Val Ser 
1               5                   10                  15  


<210>  116
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  116

Leu Ile His Val Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  117

Ile His Val Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser His 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  118

His Val Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu 
1               5                   10                  15  


<210>  119
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  119

Val Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile 
1               5                   10                  15  


<210>  120
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  120

Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile 
1               5                   10                  15  


<210>  121
<211>  11
<212>  PRT
<213>  Clostridium tetani

<400>  121

Asn Asp Tyr Lys Ala Ile Ala Asn Lys Leu Ser 
1               5                   10      


<210>  122
<211>  13
<212>  PRT
<213>  Clostridium tetani

<400>  122

Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr 
1               5                   10              


<210>  123
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  123

Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Met 
1               5                   10                  15  


<210>  124
<211>  9
<212>  PRT
<213>  Clostridium tetani

<400>  124

Leu Ile His Val Leu His Gly Leu Tyr 
1               5                   


<210>  125
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  125

Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His 
1               5                   10                  


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII-b scFv VHCDR1

<400>  126

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII-b scFv VHCDR2

<400>  127

Ile Asp Pro Ser Asp Asn Phe Ser 
1               5               


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII-b scFv VHCDR3

<400>  128

Ala Val Glu Asp Tyr 
1               5   


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII-b scFv VLCDR1

<400>  129

Arg Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  130
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII-b scFv VLCDR2

<400>  130

Arg Met Ser
1               


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14GIIICII-b scFv VLCDR3

<400>  131

Met Gln His Leu Glu Phe Pro Tyr Thr 
1               5                   


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1BIIICI-b scFv VHCDR1

<400>  132

Gly Phe Asn Ile Lys Asp Phe Asn 
1               5               


<210>  133
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1BIIICI-b VHCDR2

<400>  133

Ile Asp Pro Glu Asn Gly Asp Ala 
1               5               


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1BIIICI-b scFv VHCDR3

<400>  134

Thr Thr Gly Ser Tyr Asp Leu Asp Val Glu Tyr 
1               5                   10      


<210>  135
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1BIIICI-b scFv VLCDR1

<400>  135

Gln Asn Ile Asn Val Trp 
1               5       


<210>  136
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1BIIICI-b scFv VLCDR2

<400>  136

Lys Ala Ser
1               


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1BIIICI-b scFv VLCDR3

<400>  137

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VHCDR1 (Kabat)

<400>  138

Gly Phe Thr Phe Ser Thr Tyr Gly Met His 
1               5                   10  


<210>  139
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VHCDR2 (Kabat)

<400>  139

Gly Lys Gly Leu Glu Trp Leu Ser Tyr Ile Ser Gly Gly Ser Ser Tyr 
1               5                   10                  15      


Ile Phe Tyr Ala Asp Ser Val Arg Gly Arg 
            20                  25      


<210>  140
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VHCDR3 (Kabat)

<400>  140

Cys Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu 
1               5                   10              


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VLCDR1 (Kabat)

<400>  141

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val Tyr 
1               5                   10                  15  


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VLCDR2 (Kabat)

<400>  142

Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210>  143
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADC-1013 VLCDR3 (Kabat)

<400>  143

Cys Ala Ala Trp Asp Lys Ser Ile Ser Gly Leu Val 
1               5                   10          


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VHCDR1 (Kabat)

<400>  144

Gly Phe Ser Phe Ser Ser Thr Tyr Val Cys 
1               5                   10  


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VHCDR2 (Kabat)

<400>  145

Cys Ile Tyr Thr Gly Asp Gly Thr Asn Tyr Ser Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VHCDR3 (Kabat)

<400>  146

Ala Arg Pro Asp Ile Thr Tyr Gly Phe Ala Ile Asn Phe 
1               5                   10              


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VLCDR1 (Kabat)

<400>  147

Gln Ala Ser Gln Ser Ile Ser Ser Arg Leu Ala 
1               5                   10      


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VLCDR2 (Kabat)

<400>  148

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APX-005M VLCDR3 (Kabat)

<400>  149

Gln Cys Thr Gly Tyr Gly Ile Ser Trp Pro 
1               5                   10  


<210>  150
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-SM083-p03-C06 scFv

<400>  150

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Arg Trp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ile Ser Gly Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  151
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-SM083-p04-C04 scFv

<400>  151

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Pro Pro Ser Ser Ser Arg Ser Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Tyr Pro Leu Phe Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  152
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-SM083-p04-D04 scFv

<400>  152

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Tyr Ser Gly Gly Gly Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Phe Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
    210                 215                 220                 


Gly Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 


<210>  153
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-SM083-p04-F04 scFv

<400>  153

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Pro Arg Pro Tyr Ser Ile Phe Ile Ser Ile Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Thr Tyr Gly Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  154
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-SM083-p04-G04 scFv

<400>  154

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Val Pro Tyr Ser Pro Tyr Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Thr Tyr Ser Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  155
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-SM083-p04-H04 scFv

<400>  155

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Thr Tyr Gly Gly Phe Pro Phe Ser Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Arg Phe Leu Ser Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


