                         SEQUENCE LISTING

<110>  Synpromics Limited
 
<120>  Liver-Specific Expression Control Sequences

<130>  P254036WO1

<150>  GB1818816.9
<151>  2018-11-19

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 (alpha mic/bik or LVR_CRE0051_AMBP)

<400>  1
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc                            100


<210>  2
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V1 (LVR_CRE0077_V1)

<400>  2
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccc           56


<210>  3
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V2 (LVR_CRE0078_V2)

<400>  3
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacac                       45


<210>  4
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0074_SEPP1

<400>  4
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

t                                                                       61


<210>  5
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0058_APOB

<400>  5
ggcccgggag gcgccctttg gaccttttgc aatcctggcg                             40


<210>  6
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0065_APOA1

<400>  6
cactgaaccc ttgacccctg ccctgcagcc cccgcagctt gctgtttgcc cactctattt       60

gcccagcccc ag                                                           72


<210>  7
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0065_APOA1_v1

<400>  7
cactgaaccc ttgacccctg ccctgcagcc cccgcagctt gctgtttgcc cactctattt       60

gcccagcccc agggacagag ctgatccttg aactcttaag ttccac                     106


<210>  8
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0066_NR1I2

<400>  8
ccctggagag tcctttagca gggcaaagtg caacataggc agaccttaag ggatgactca       60

gtaacagata agctttgtgt gcctgca                                           87


<210>  9
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0052_G6PC

<400>  9
gggcatataa aacaggggca aggcacagac tcatagcaga gcaatcacca ccaagcctgg       60

aataactgca gccacc                                                       76


<210>  10
<211>  226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPINA7 proximal promoter (LVR_CRE0079_SERPINA7)

<400>  10
ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta       60

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      120

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      180

atgctataaa aatggaaaga tgttgctttc tgagagatgc gccacc                     226


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0080_PROC

<400>  11
aagcaaatat ttgtggttat ggattaactc gaa                                    33


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0081_APOA1

<400>  12
ctgtttgccc actctatttg ccc                                               23


<210>  13
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0061_APOB

<400>  13
ggcgcccttt ggaccttttg caatcctgg                                         29


<210>  14
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_CRE0082_APOC4

<400>  14
agcaaacagc aaacac                                                       16


<210>  15
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_127

<400>  15
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

tggcccggga ggcgcccttt ggaccttttg caatcctggc gcactgaacc cttgacccct      120

gccctgcagc ccccgcagct tgctgtttgc ccactctatt tgcccagccc cagggacaga      180

gctgatcctt gaactcttaa gttccac                                          207


<210>  16
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_127_A1

<400>  16
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccagaa tgaacattga      120

actttggact atacctgagg ggtgaggtaa acaacaggac tataaatggc ccgggaggcg      180

ccctttggac cttttgcaat cctggcgcac tgaacccttg acccctgccc tgcagccccc      240

gcagcttgct gtttgcccac tctatttgcc cagccccagg gacagagctg atccttgaac      300

tcttaagttc cac                                                         313


<210>  17
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_127_V1

<400>  17
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccagaatgaa cattgaactt tggactatac ctgaggggtg aggtaaacaa caggactata      120

aatggcccgg gaggcgccct ttggaccttt tgcaatcctg gcgcactgaa cccttgaccc      180

ctgccctgca gcccccgcag cttgctgttt gcccactcta tttgcccagc cccagggaca      240

gagctgatcc ttgaactctt aagttccac                                        269


<210>  18
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_127_V2

<400>  18
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cagaatgaac       60

attgaacttt ggactatacc tgaggggtga ggtaaacaac aggactataa atggcccggg      120

aggcgccctt tggacctttt gcaatcctgg cgcactgaac ccttgacccc tgccctgcag      180

cccccgcagc ttgctgtttg cccactctat ttgcccagcc ccagggacag agctgatcct      240

tgaactctta agttccac                                                    258


<210>  19
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_131

<400>  19
ggcccgggag gcgccctttg gaccttttgc aatcctggcg cactgaaccc ttgacccctg       60

ccctgcagcc cccgcagctt gctgtttgcc cactctattt gcccagcccc agccctggag      120

agtcctttag cagggcaaag tgcaacatag gcagacctta agggatgact cagtaacaga      180

taagctttgt gtgcctgca                                                   199


<210>  20
<211>  305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_131_A1

<400>  20
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccggcc cgggaggcgc      120

cctttggacc ttttgcaatc ctggcgcact gaacccttga cccctgccct gcagcccccg      180

cagcttgctg tttgcccact ctatttgccc agccccagcc ctggagagtc ctttagcagg      240

gcaaagtgca acataggcag accttaaggg atgactcagt aacagataag ctttgtgtgc      300

ctgca                                                                  305


<210>  21
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_131_V1

<400>  21
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccggcccggg aggcgccctt tggacctttt gcaatcctgg cgcactgaac ccttgacccc      120

tgccctgcag cccccgcagc ttgctgtttg cccactctat ttgcccagcc ccagccctgg      180

agagtccttt agcagggcaa agtgcaacat aggcagacct taagggatga ctcagtaaca      240

gataagcttt gtgtgcctgc a                                                261


<210>  22
<211>  250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_131_V2

<400>  22
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cggcccggga       60

ggcgcccttt ggaccttttg caatcctggc gcactgaacc cttgacccct gccctgcagc      120

ccccgcagct tgctgtttgc ccactctatt tgcccagccc cagccctgga gagtccttta      180

gcagggcaaa gtgcaacata ggcagacctt aagggatgac tcagtaacag ataagctttg      240

tgtgcctgca                                                             250


<210>  23
<211>  260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_132

<400>  23
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

tggcccggga ggcgcccttt ggaccttttg caatcctggc gcactgaacc cttgacccct      120

gccctgcagc ccccgcagct tgctgtttgc ccactctatt tgcccagccc cagccctgga      180

gagtccttta gcagggcaaa gtgcaacata ggcagacctt aagggatgac tcagtaacag      240

ataagctttg tgtgcctgca                                                  260


<210>  24
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_132_A1

<400>  24
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccagaa tgaacattga      120

actttggact atacctgagg ggtgaggtaa acaacaggac tataaatggc ccgggaggcg      180

ccctttggac cttttgcaat cctggcgcac tgaacccttg acccctgccc tgcagccccc      240

gcagcttgct gtttgcccac tctatttgcc cagccccagc cctggagagt cctttagcag      300

ggcaaagtgc aacataggca gaccttaagg gatgactcag taacagataa gctttgtgtg      360

cctgca                                                                 366


<210>  25
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_132_V1

<400>  25
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccagaatgaa cattgaactt tggactatac ctgaggggtg aggtaaacaa caggactata      120

aatggcccgg gaggcgccct ttggaccttt tgcaatcctg gcgcactgaa cccttgaccc      180

ctgccctgca gcccccgcag cttgctgttt gcccactcta tttgcccagc cccagccctg      240

gagagtcctt tagcagggca aagtgcaaca taggcagacc ttaagggatg actcagtaac      300

agataagctt tgtgtgcctg ca                                               322


<210>  26
<211>  311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_132_V2

<400>  26
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cagaatgaac       60

attgaacttt ggactatacc tgaggggtga ggtaaacaac aggactataa atggcccggg      120

aggcgccctt tggacctttt gcaatcctgg cgcactgaac ccttgacccc tgccctgcag      180

cccccgcagc ttgctgtttg cccactctat ttgcccagcc ccagccctgg agagtccttt      240

agcagggcaa agtgcaacat aggcagacct taagggatga ctcagtaaca gataagcttt      300

gtgtgcctgc a                                                           311


<210>  27
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_133

<400>  27
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

tggcccggga ggcgcccttt ggaccttttg caatcctggc g                          101


<210>  28
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_133_A1

<400>  28
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccagaa tgaacattga      120

actttggact atacctgagg ggtgaggtaa acaacaggac tataaatggc ccgggaggcg      180

ccctttggac cttttgcaat cctggcg                                          207


<210>  29
<211>  163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_133_V1

<400>  29
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccagaatgaa cattgaactt tggactatac ctgaggggtg aggtaaacaa caggactata      120

aatggcccgg gaggcgccct ttggaccttt tgcaatcctg gcg                        163


<210>  30
<211>  152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM_LVR_133_V2

<400>  30
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cagaatgaac       60

attgaacttt ggactatacc tgaggggtga ggtaaacaac aggactataa atggcccggg      120

aggcgccctt tggacctttt gcaatcctgg cg                                    152


<210>  31
<211>  283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_127

<400>  31
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

tggcccggga ggcgcccttt ggaccttttg caatcctggc gcactgaacc cttgacccct      120

gccctgcagc ccccgcagct tgctgtttgc ccactctatt tgcccagccc cagggacaga      180

gctgatcctt gaactcttaa gttccacggg catataaaac aggggcaagg cacagactca      240

tagcagagca atcaccacca agcctggaat aactgcagcc acc                        283


<210>  32
<211>  389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_127_A1

<400>  32
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccagaa tgaacattga      120

actttggact atacctgagg ggtgaggtaa acaacaggac tataaatggc ccgggaggcg      180

ccctttggac cttttgcaat cctggcgcac tgaacccttg acccctgccc tgcagccccc      240

gcagcttgct gtttgcccac tctatttgcc cagccccagg gacagagctg atccttgaac      300

tcttaagttc cacgggcata taaaacaggg gcaaggcaca gactcatagc agagcaatca      360

ccaccaagcc tggaataact gcagccacc                                        389


<210>  33
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_127_V1

<400>  33
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccagaatgaa cattgaactt tggactatac ctgaggggtg aggtaaacaa caggactata      120

aatggcccgg gaggcgccct ttggaccttt tgcaatcctg gcgcactgaa cccttgaccc      180

ctgccctgca gcccccgcag cttgctgttt gcccactcta tttgcccagc cccagggaca      240

gagctgatcc ttgaactctt aagttccacg ggcatataaa acaggggcaa ggcacagact      300

catagcagag caatcaccac caagcctgga ataactgcag ccacc                      345


<210>  34
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_127_V2

<400>  34
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cagaatgaac       60

attgaacttt ggactatacc tgaggggtga ggtaaacaac aggactataa atggcccggg      120

aggcgccctt tggacctttt gcaatcctgg cgcactgaac ccttgacccc tgccctgcag      180

cccccgcagc ttgctgtttg cccactctat ttgcccagcc ccagggacag agctgatcct      240

tgaactctta agttccacgg gcatataaaa caggggcaag gcacagactc atagcagagc      300

aatcaccacc aagcctggaa taactgcagc cacc                                  334


<210>  35
<211>  275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_131

<400>  35
ggcccgggag gcgccctttg gaccttttgc aatcctggcg cactgaaccc ttgacccctg       60

ccctgcagcc cccgcagctt gctgtttgcc cactctattt gcccagcccc agccctggag      120

agtcctttag cagggcaaag tgcaacatag gcagacctta agggatgact cagtaacaga      180

taagctttgt gtgcctgcag ggcatataaa acaggggcaa ggcacagact catagcagag      240

caatcaccac caagcctgga ataactgcag ccacc                                 275


<210>  36
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_131_A1

<400>  36
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccggcc cgggaggcgc      120

cctttggacc ttttgcaatc ctggcgcact gaacccttga cccctgccct gcagcccccg      180

cagcttgctg tttgcccact ctatttgccc agccccagcc ctggagagtc ctttagcagg      240

gcaaagtgca acataggcag accttaaggg atgactcagt aacagataag ctttgtgtgc      300

ctgcagggca tataaaacag gggcaaggca cagactcata gcagagcaat caccaccaag      360

cctggaataa ctgcagccac c                                                381


<210>  37
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_131_V1

<400>  37
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccggcccggg aggcgccctt tggacctttt gcaatcctgg cgcactgaac ccttgacccc      120

tgccctgcag cccccgcagc ttgctgtttg cccactctat ttgcccagcc ccagccctgg      180

agagtccttt agcagggcaa agtgcaacat aggcagacct taagggatga ctcagtaaca      240

gataagcttt gtgtgcctgc agggcatata aaacaggggc aaggcacaga ctcatagcag      300

agcaatcacc accaagcctg gaataactgc agccacc                               337


<210>  38
<211>  326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_131_V2

<400>  38
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cggcccggga       60

ggcgcccttt ggaccttttg caatcctggc gcactgaacc cttgacccct gccctgcagc      120

ccccgcagct tgctgtttgc ccactctatt tgcccagccc cagccctgga gagtccttta      180

gcagggcaaa gtgcaacata ggcagacctt aagggatgac tcagtaacag ataagctttg      240

tgtgcctgca gggcatataa aacaggggca aggcacagac tcatagcaga gcaatcacca      300

ccaagcctgg aataactgca gccacc                                           326


<210>  39
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_132

<400>  39
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

tggcccggga ggcgcccttt ggaccttttg caatcctggc gcactgaacc cttgacccct      120

gccctgcagc ccccgcagct tgctgtttgc ccactctatt tgcccagccc cagccctgga      180

gagtccttta gcagggcaaa gtgcaacata ggcagacctt aagggatgac tcagtaacag      240

ataagctttg tgtgcctgca gggcatataa aacaggggca aggcacagac tcatagcaga      300

gcaatcacca ccaagcctgg aataactgca gccacc                                336


<210>  40
<211>  442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_132_A1

<400>  40
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccagaa tgaacattga      120

actttggact atacctgagg ggtgaggtaa acaacaggac tataaatggc ccgggaggcg      180

ccctttggac cttttgcaat cctggcgcac tgaacccttg acccctgccc tgcagccccc      240

gcagcttgct gtttgcccac tctatttgcc cagccccagc cctggagagt cctttagcag      300

ggcaaagtgc aacataggca gaccttaagg gatgactcag taacagataa gctttgtgtg      360

cctgcagggc atataaaaca ggggcaaggc acagactcat agcagagcaa tcaccaccaa      420

gcctggaata actgcagcca cc                                               442


<210>  41
<211>  398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_132_V1

<400>  41
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccagaatgaa cattgaactt tggactatac ctgaggggtg aggtaaacaa caggactata      120

aatggcccgg gaggcgccct ttggaccttt tgcaatcctg gcgcactgaa cccttgaccc      180

ctgccctgca gcccccgcag cttgctgttt gcccactcta tttgcccagc cccagccctg      240

gagagtcctt tagcagggca aagtgcaaca taggcagacc ttaagggatg actcagtaac      300

agataagctt tgtgtgcctg cagggcatat aaaacagggg caaggcacag actcatagca      360

gagcaatcac caccaagcct ggaataactg cagccacc                              398


<210>  42
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_132_V2

<400>  42
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cagaatgaac       60

attgaacttt ggactatacc tgaggggtga ggtaaacaac aggactataa atggcccggg      120

aggcgccctt tggacctttt gcaatcctgg cgcactgaac ccttgacccc tgccctgcag      180

cccccgcagc ttgctgtttg cccactctat ttgcccagcc ccagccctgg agagtccttt      240

agcagggcaa agtgcaacat aggcagacct taagggatga ctcagtaaca gataagcttt      300

gtgtgcctgc agggcatata aaacaggggc aaggcacaga ctcatagcag agcaatcacc      360

accaagcctg gaataactgc agccacc                                          387


<210>  43
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_133

<400>  43
agaatgaaca ttgaactttg gactatacct gaggggtgag gtaaacaaca ggactataaa       60

tggcccggga ggcgcccttt ggaccttttg caatcctggc gctcttttgt tttacatgaa      120

gggtctggca gccaaagcaa tcactcaaag ttcaaacctt atcatttttt gctttgttcc      180

tcttggcctt ggttttgtac atcagctttg aaaataccat cccagggtta atgctggggt      240

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag      300

atgttgcttt ctgagagatg cgccacc                                          327


<210>  44
<211>  433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_133_A1

<400>  44
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc tgtaccagaa tgaacattga      120

actttggact atacctgagg ggtgaggtaa acaacaggac tataaatggc ccgggaggcg      180

ccctttggac cttttgcaat cctggcgctc ttttgtttta catgaagggt ctggcagcca      240

aagcaatcac tcaaagttca aaccttatca ttttttgctt tgttcctctt ggccttggtt      300

ttgtacatca gctttgaaaa taccatccca gggttaatgc tggggttaat ttataactaa      360

gagtgctcta gttttgcaat acaggacatg ctataaaaat ggaaagatgt tgctttctga      420

gagatgcgcc acc                                                         433


<210>  45
<211>  389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_133_V1

<400>  45
aagcaaatat ttgtggttat ggattaactc gaactgtttg cccactctat ttgccctgta       60

ccagaatgaa cattgaactt tggactatac ctgaggggtg aggtaaacaa caggactata      120

aatggcccgg gaggcgccct ttggaccttt tgcaatcctg gcgctctttt gttttacatg      180

aagggtctgg cagccaaagc aatcactcaa agttcaaacc ttatcatttt ttgctttgtt      240

cctcttggcc ttggttttgt acatcagctt tgaaaatacc atcccagggt taatgctggg      300

gttaatttat aactaagagt gctctagttt tgcaatacag gacatgctat aaaaatggaa      360

agatgttgct ttctgagaga tgcgccacc                                        389


<210>  46
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LVR_133_V2

<400>  46
ggcgcccttt ggaccttttg caatcctgga gcaaacagca aacactgtac cagaatgaac       60

attgaacttt ggactatacc tgaggggtga ggtaaacaac aggactataa atggcccggg      120

aggcgccctt tggacctttt gcaatcctgg cgctcttttg ttttacatga agggtctggc      180

agccaaagca atcactcaaa gttcaaacct tatcattttt tgctttgttc ctcttggcct      240

tggttttgta catcagcttt gaaaatacca tcccagggtt aatgctgggg ttaatttata      300

actaagagtg ctctagtttt gcaatacagg acatgctata aaaatggaaa gatgttgctt      360

tctgagagat gcgccacc                                                    378


<210>  47
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP1

<400>  47
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc       60

tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc      120

cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt      180

agtgtgagag gggaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc      240

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt      300

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc      360

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg      420

caccaccact gacctgggac agtgaatccg gactctaagg taaatataaa atttttaagt      480

gtataatgtg ttaaactact gattctaatt gtttctctct tttagattcc aacctttgga      540

actgaattct agaccacc                                                    558


<210>  48
<211>  580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV-IE

<400>  48
atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata       60

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      120

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      180

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      240

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      300

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      360

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      420

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      480

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      540

ggtctatata agcagagctg gtttagtgaa ccgtcagatc                            580


<210>  49
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in V1

<400>  49
agcaaatatt t                                                            11


<210>  50
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in V1

<400>  50
aaatatttgt gg                                                           12


<210>  51
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF1 TFBS in V1

<400>  51
ggttatggat taact                                                        15


<210>  52
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in V1

<400>  52
ctgtttgccc                                                              10


<210>  53
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in V1 and CRE0065

<400>  53
ctatttgccc                                                              10


<210>  54
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF4 TFBS in V2

<400>  54
cgccctttgg acc                                                          13


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c/EBP TFBS in V2

<400>  55
gaccttttgc aatcctgg                                                     18


<210>  56
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in V2

<400>  56
ctgtttgct                                                                9


<210>  57
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in V2

<400>  57
gtgtttgctg                                                              10


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF4 binding site in CRE0074

<400>  58
aacattgaac tttggacta                                                    19


<210>  59
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FoxO1a TFBS in CRE0074

<400>  59
gtaaacaa                                                                 8


<210>  60
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF4 TFBS in CRE0058

<400>  60
cgccctttgg acc                                                          13


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c/EBP TFBS in CRE0058

<400>  61
gaccttttgc aatcctgg                                                     18


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RxR alpha TFBS in CRE0065 and CRE0065.1

<400>  62
actgaaccct tgacccctgc cct                                               23


<210>  63
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in CRE0065 and CRE0065.1

<400>  63
ctgtttgccc                                                              10


<210>  64
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF4 TFBS in CRE0065.1

<400>  64
tgatccttga actct                                                        15


<210>  65
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of SEQ ID NO: 2


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  optional spacer sequence

<400>  65
agcaaatatt tgtggttatg gattaactnc tgtttgcccn ctatttgccc                  50


<210>  66
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of SEQ ID NO: 3

<400>  66
cgccctttgg accttttgca atcctggagc aaacagcaaa cac                         43


<210>  67
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of A1 (SEQ ID NO: 1)


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  optional spacer sequence

<400>  67
gttaattttt aaangtggcc cttggntgtt tgcntggtta ataatctcan acaaaca          57


<210>  68
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the functional variant of LVR_CRE0074_SEPP1


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  optional spacer sequence

<400>  68
aacattgaac tttggactan gtaaacaa                                          28


<210>  69
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of LVR_CRE0058_APOB

<400>  69
gcgccctttg gaccttttgc aatcctgg                                          28


<210>  70
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of LVR_CRE0065_APOA1


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  optional spacer sequence

<400>  70
actgaaccct tgacccctnc tgtttgcccn tatttgccc                              39


<210>  71
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of LVR_CRE0065_APOA1_v1


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  optional spacer sequence

<400>  71
actgaaccct tgacccctnc tgtttgcccn tatttgcccn tgatccttga actct            55


<210>  72
<211>  1775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CBA

<400>  72
agatctgaat tcggtaccta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtcgaggt gagccccacg ttctgcttca ctctccccat      420

ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat tttgtgcagc      480

gatgggggcg gggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg     1020

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca     1140

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg     1200

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc     1260

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg     1320

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc     1380

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac     1440

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga     1500

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc ggggctgtcc     1560

gcggggggac ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt     1620

gaccggcggc tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct     1680

cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tcctcgaaga     1740

tctaggcaac gcgtctcgag gcggccgccg ccacc                                1775


<210>  73
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  functional variant of LVR_CRE0066_NR1I2


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  optional spacer sequence

<400>  73
gcagggcaaa gtgcangatg actcag                                            26


<210>  74
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF1 TFBS in CRE0051

<400>  74
gttaattttt aaa                                                          13


<210>  75
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF4 TFBS in CRE0051

<400>  75
gtggcccttg g                                                            11


<210>  76
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in CRE0051

<400>  76
tgtttgc                                                                  7


<210>  77
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF1 TFBS in CRE0051

<400>  77
tggttaataa tctca                                                        15


<210>  78
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF3 TFBS in CRE0051

<400>  78
acaaaca                                                                  7


<210>  79
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF4G TFBS in CRE0066

<400>  79
gcagggcaaa gtgca                                                        15


<210>  80
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS::JUN TFBS in CRE0066

<400>  80
gatgactcag                                                              10


<210>  81
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence not comprised in CRM/liver-specific promoter

<400>  81
ggacttagcc cctgtttgct cctccgataa ctggggtgac cttggttaat attcacca         58


<210>  82
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence not comprised in CRM/liver-specific promoter

<400>  82
gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc a                51


<210>  83
<211>  890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBG

<400>  83
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagagactg cagaagttgg tcgtgaggca      720

ctgggcaggt aagtatcaag gttacaagac aggtttaagg agaccaatag aaactgggct      780

tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt actgacatcc      840

actttgcctt tctctccaca gggcaatccg gtactgttgg taaagccacc                 890


