                         SEQUENCE LISTING

<110>  Xios Therapeutics, Inc.
 
<120>  COMPOUNDS AND USES THEREROF

<130>  51208-003WO2

<140>  PCT/US19/62025
<141>  2019-11-18

<150>  62/769,317
<151>  2018-11-19

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Val Trp Leu Asn Ser Asn Leu Gln 
        35                  40                  45              


Asn Val Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser 
                405                 410         


<210>  2
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Glu Thr Gln Asp Ala Leu Tyr Val Ala Leu Glu Leu Val 
1               5                   10                  15      


Ile Ala Ala Leu Ser Val Ala Gly Asn Val Leu Val Cys Ala Ala Val 
            20                  25                  30          


Gly Thr Ala Asn Thr Leu Gln Thr Pro Thr Asn Tyr Phe Leu Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Asp Val Ala Val Gly Leu Phe Ala Ile Pro Phe Ala 
    50                  55                  60                  


Ile Thr Ile Ser Leu Gly Phe Cys Thr Asp Phe Tyr Gly Cys Leu Phe 
65                  70                  75                  80  


Leu Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu 
                85                  90                  95      


Leu Ala Val Ala Val Asp Arg Tyr Leu Ala Ile Cys Val Pro Leu Arg 
            100                 105                 110         


Tyr Lys Ser Leu Val Thr Gly Thr Arg Ala Arg Gly Val Ile Ala Val 
        115                 120                 125             


Leu Trp Val Leu Ala Phe Gly Ile Gly Leu Thr Pro Phe Leu Gly Trp 
    130                 135                 140                 


Asn Ser Lys Asp Ser Ala Thr Asn Asn Cys Thr Glu Pro Trp Asp Gly 
145                 150                 155                 160 


Thr Thr Asn Glu Ser Cys Cys Leu Val Lys Cys Leu Phe Glu Asn Val 
                165                 170                 175     


Val Pro Met Ser Tyr Met Val Tyr Phe Asn Phe Phe Gly Cys Val Leu 
            180                 185                 190         


Pro Pro Leu Leu Ile Met Leu Val Ile Tyr Ile Lys Ile Phe Leu Val 
        195                 200                 205             


Ala Cys Arg Gln Leu Gln Arg Thr Glu Leu Met Asp His Ser Arg Thr 
    210                 215                 220                 


Thr Leu Gln Arg Glu Ile His Ala Ala Lys Ser Leu Ala Met Ile Val 
225                 230                 235                 240 


Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val Asn Cys Val 
                245                 250                 255     


Thr Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys Trp Ala Met 
            260                 265                 270         


Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val Asn Pro Ile 
        275                 280                 285             


Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Thr Phe His Lys Ile 
    290                 295                 300                 


Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser Gly Asn Gly 
305                 310                 315                 320 


Gln Ala Gly Val Gln Pro Ala Leu Gly Val Gly Leu 
                325                 330         


