                         SEQUENCE LISTING

<110>  Fulcrum Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR INCREASING FETAL HEMOGLOBIN AND 
       TREATING SICKLE CELL DISEASE

<130>  FULC-033/01WO (326242-2119)

<150>  62/769,796
<151>  2018-11-20

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Ala Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210>  3
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  4
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  5
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  5
gcaaaggaac ggctacgacc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  6
ttgaaacgtg gagagaccag                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  7
gctgtcggaa atcatggaga                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  8
gcaggatgtg gaccaacgtg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  9
tgagcctgcc tacctgacag                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  10
cagtccgggc aagaggcgga                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  11
gacttgcccc taattttcga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  12
tgcactgctg gatgaagtgc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  13
ggagcgaact cgatgggcta                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
actactggcc tccaaaggaa                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  15
tgtgtgagct cagggagctg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  16
gtttgtgaag gctaaagccc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  17
ggggacagcg acgatgagga                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  18
atggtgcgct accacgaggg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  19
ggagggcatg agaaagtgga                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  20
ggtttagtgc gttccagggg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  21
gctgcatgac caggtagtag                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  22
ggagagctat aaacagatgc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  23
tcttttggga gccaaaccca                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  24
tctcaaagag ctggaaactg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  25
gaggagggag atgaccacga                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  26
ataaggtctc acctgaaact                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  27
aggccccgca ctgattgcac                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  28
aataaggctc caaaagacca                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  29
gcaatgccct ttcagaagcg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  30
gtagacagta atgggagcga                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  31
gaggctggga acaacagcag                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  32
gtttggccac atagttgctg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  33
ggtgctgtgt cgggatgaga                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  34
tcgcgattta gaagttgtgg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  35
aatgagctct gctgtgcagg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  36
gaacctggca cctcaaggat                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  37
taagagccct gaggatccat                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  38
gggttctgtg tcaattcccg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  39
gcccggactg ggagatgaca                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  40
gccatacctc ccctacacca                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  41
gccttgatga agcactgcag                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  42
cccgtggcag aagatggctg                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  43
acatctcttg caaacagagt                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  44
ggtgtgtgag gctggaccgg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  45
ggggctgctg ctgaccaagg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  46
gctcagcaca gagtgcgcca                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  47
caccatggac atctacgcca                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  48
tgagcgggct tattccgcag                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  49
gtttgtgcaa ggcaaagact                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  50
agtgggaagc atcattgtgt                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  51
actgggctaa cctaaagctg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  52
gacctttgtg agcgagctgg                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  53
agatcgtaca tgttcaccgg                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  54
ggacactgcc caccagacag                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  55
ggcacctctg agctgaggag                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  56
gaagagaggg ccagttgtga                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  57
gaggcggatg gacacggacg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  58
caaattcatt aagtcctccc                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  59
gaggtcttcg atcagtgggg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  60
gctgggaatc cctgctgcag                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  61
caagcccctt tgcattgaag                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  62
tggcagggag tgctacactg                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  63
gacaaccgcc atccagactg                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  64
gaaaaggctg gtgaaagtta                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  65
gaagaccgcc ctttgggagg                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  66
gaagccttgc acagagcctg                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  67
gagtcttgaa gatatcagga                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  68
gcggggtgtc tacacagaga                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  69
taatcagcaa gcctttgatg                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  70
actccgctcc ctgctcgccg                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  71
ggagttgatg atcttgcaga                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  72
gcatttgctg caggaccccg                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  73
ataatgacaa gaagaacccc                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  74
cctaaagcct caaaatagga                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  75
gaagccttgc acagagcctg                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  76
gagtcttgaa gatatcagga                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  77
ttagctggct taaaggatgg                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  78
ggaatgccag tggagagcca                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  79
tgaaagacaa gtcgtccggg                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  80
gtagcaccaa ctctcagcta                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  81
ggccctagag aagtatggga                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  82
ggaggacaag aagatgcagc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  83
gggaaatgcg caccatgggg                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  84
taagagccct gaggatccac                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  85
gagctacgtg gtgaaccgtg                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  86
ggatgaacct atgggagagg                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  87
gcagatgcca gcaaacatgg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  88
aggaggagca gaaggacctg                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  89
ggcacttagt aaagtcagtg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  90
aaggctgtcc aacaggaata                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  91
taactttagc ttttgccggg                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  92
cgggcatata ggtttgtgca                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  93
gtttgcgagt aaaccccaaa                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  94
gagcatctca aacacaacga                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  95
cgagatcaag ttgtacgtta                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  96
tcatctacgg caaactctat                                                   20


<210>  97
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  97
ccggcacaga tcaaggtagt gaaatctcga gatttcacta ccttgatctg tgttttttg        59


<210>  98
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  98
ccggcaaggt agtgaaattc tcctactcga gtaggagaat ttcactacct tgttttttg        59


<210>  99
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  99
ccggcagatg agttaggagg actgtctcga gacagtcctc ctaactcatc tgttttttg        59


<210>  100
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  100
ccggcacaag gctatcttag cagctctcga gagctgctaa gatagccttg tgttttttg        59


<210>  101
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  101
ccgggactat atccagggct tattgctcga gcaataagcc ctggatatag tctttttg         58


<210>  102
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  102
ccggcgtaag aataacagtg gtcttctcga gaagaccact gttattctta cgtttttg         58


<210>  103
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  103
ccggcgtgtg ccaaatggtt tgaaactcga gtttcaaacc atttggcaca cgtttttg         58


<210>  104
<211>  584
<212>  DNA
<213>  Homo sapiens

<400>  104
acactcgctt ctggaacgtc tgaggttatc aataagctcc tagtccagac gccatgggtc       60

atttcacaga ggaggacaag gctactatca caagcctgtg gggcaaggtg aatgtggaag      120

atgctggagg agaaaccctg ggaaggctcc tggttgtcta cccatggacc cagaggttct      180

ttgacagctt tggcaacctg tcctctgcct ctgccatcat gggcaacccc aaagtcaagg      240

cacatggcaa gaaggtgctg acttccttgg gagatgccac aaagcacctg gatgatctca      300

agggcacctt tgcccagctg agtgaactgc actgtgacaa gctgcatgtg gatcctgaga      360

acttcaagct cctgggaaat gtgctggtga ccgttttggc aatccatttc ggcaaagaat      420

tcacccctga ggtgcaggct tcctggcaga agatggtgac tgcagtggcc agtgccctgt      480

cctccagata ccactgagct cactgcccat gattcagagc tttcaaggat aggctttatt      540

ctgcaagcaa tacaaataat aaatctattc tgctgagaga tcac                       584


<210>  105
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  105
acactcgctt ctggaacgtc tgaggttatc aataagctcc tagtccagac gccatgggtc       60

atttcacaga ggaggacaag gctactatca caagcctgtg gggcaaggtg aatgtggaag      120

atgctggagg agaaaccctg ggaaggctcc tggttgtcta cccatggacc cagaggttct      180

ttgacagctt tggcaacctg tcctctgcct ctgccatcat gggcaacccc aaagtcaagg      240

cacatggcaa gaaggtgctg acttccttgg gagatgccat aaagcacctg gatgatctca      300

agggcacctt tgcccagctg agtgaactgc actgtgacaa gctgcatgtg gatcctgaga      360

acttcaagct cctgggaaat gtgctggtga ccgttttggc aatccatttc ggcaaagaat      420

tcacccctga ggtgcaggct tcctggcaga agatggtgac tggagtggcc agtgccctgt      480

cctccagata ccactgagct cactgcccat gatgcagagc tttcaaggat aggctttatt      540

ctgcaagcaa tcaaataata aatctattct gctaagagat cacaca                     586


<210>  106
<211>  577
<212>  DNA
<213>  Homo sapiens

<400>  106
actcttctgg tccccacaga ctcagagaga acccaccatg gtgctgtctc ctgccgacaa       60

gaccaacgtc aaggccgcct ggggtaaggt cggcgcgcac gctggcgagt atggtgcgga      120

ggccctggag aggatgttcc tgtccttccc caccaccaag acctacttcc cgcacttcga      180

cctgagccac ggctctgccc aggttaaggg ccacggcaag aaggtggccg acgcgctgac      240

caacgccgtg gcgcacgtgg acgacatgcc caacgcgctg tccgccctga gcgacctgca      300

cgcgcacaag cttcgggtgg acccggtcaa cttcaagctc ctaagccact gcctgctggt      360

gaccctggcc gcccacctcc ccgccgagtt cacccctgcg gtgcacgcct ccctggacaa      420

gttcctggct tctgtgagca ccgtgctgac ctccaaatac cgttaagctg gagcctcggt      480

ggccatgctt cttgcccctt gggcctcccc ccagcccctc ctccccttcc tgcacccgta      540

cccccgtggt ctttgaataa agtctgagtg ggcggca                               577


<210>  107
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  107
actcttctgg tccccacaga ctcagagaga acccaccatg gtgctgtctc ctgccgacaa       60

gaccaacgtc aaggccgcct ggggtaaggt cggcgcgcac gctggcgagt atggtgcgga      120

ggccctggag aggatgttcc tgtccttccc caccaccaag acctacttcc cgcacttcga      180

cctgagccac ggctctgccc aggttaaggg ccacggcaag aaggtggccg acgcgctgac      240

caacgccgtg gcgcacgtgg acgacatgcc caacgcgctg tccgccctga gcgacctgca      300

cgcgcacaag cttcgggtgg acccggtcaa cttcaagctc ctaagccact gcctgctggt      360

gaccctggcc gcccacctcc ccgccgagtt cacccctgcg gtgcacgcct ccctggacaa      420

gttcctggct tctgtgagca ccgtgctgac ctccaaatac cgttaagctg gagcctcggt      480

agccgttcct cctgcccgct gggcctccca acgggccctc ctcccctcct tgcaccggcc      540

cttcctggtc tttgaataaa gtctgagtgg gcagca                                576


<210>  108
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ser Asn Leu Ser Lys Gly Thr Gly Ser Arg Lys Asp Thr Lys Met 
1               5                   10                  15      


Arg Ile Arg Ala Phe Pro Met Thr Met Asp Glu Lys Tyr Val Asn Ser 
            20                  25                  30          


Ile Trp Asp Leu Leu Lys Asn Ala Ile Gln Glu Ile Gln Arg Lys Asn 
        35                  40                  45              


Asn Ser Gly Leu Ser Phe Glu Glu Leu Tyr Arg Asn Ala Tyr Thr Met 
    50                  55                  60                  


Val Leu His Lys His Gly Glu Lys Leu Tyr Thr Gly Leu Arg Glu Val 
65                  70                  75                  80  


Val Thr Glu His Leu Ile Asn Lys Val Arg Glu Asp Val Leu Asn Ser 
                85                  90                  95      


Leu Asn Asn Asn Phe Leu Gln Thr Leu Asn Gln Ala Trp Asn Asp His 
            100                 105                 110         


Gln Thr Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg 
        115                 120                 125             


Val Tyr Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu 
    130                 135                 140                 


Ile Ile Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His 
145                 150                 155                 160 


Leu Arg Gln Thr Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu 
                165                 170                 175     


Val Val Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile 
            180                 185                 190         


Leu Gly Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro 
        195                 200                 205             


Phe Leu Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe 
    210                 215                 220                 


Leu Ala Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg 
225                 230                 235                 240 


Ile Asn Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Thr 
                245                 250                 255     


Glu Glu Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His 
            260                 265                 270         


Met Lys Thr Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu 
        275                 280                 285             


Lys Asn Gly Lys Thr Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser 
    290                 295                 300                 


Arg Val Pro Asn Gly Leu Lys Thr Met Cys Glu Cys Met Ser Ser Tyr 
305                 310                 315                 320 


Leu Arg Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys 
                325                 330                 335     


Asn Pro Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe 
            340                 345                 350         


Asp Arg Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln 
        355                 360                 365             


Thr Ile Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser 
    370                 375                 380                 


Pro Glu Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val 
385                 390                 395                 400 


Lys Gly Leu Thr Glu Gln Glu Val Glu Thr Ile Leu Asp Lys Ala Met 
                405                 410                 415     


Val Leu Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr 
            420                 425                 430         


Lys Gln His Leu Ala Arg Arg Leu Leu Thr Asn Lys Ser Val Ser Asp 
        435                 440                 445             


Asp Ser Glu Lys Asn Met Ile Ser Lys Leu Lys Thr Glu Cys Gly Cys 
    450                 455                 460                 


Gln Phe Thr Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser 
465                 470                 475                 480 


Asn Thr Thr Met Asp Glu Phe Arg Gln His Leu Gln Ala Thr Gly Val 
                485                 490                 495     


Ser Leu Gly Gly Val Asp Leu Thr Val Arg Val Leu Thr Thr Gly Tyr 
            500                 505                 510         


Trp Pro Thr Gln Ser Ala Thr Pro Lys Cys Asn Ile Pro Pro Ala Pro 
        515                 520                 525             


Arg His Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser 
    530                 535                 540                 


Gly Arg Gln Leu Thr Leu Gln His His Met Gly Ser Ala Asp Leu Asn 
545                 550                 555                 560 


Ala Thr Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly 
                565                 570                 575     


Val Gly Gly Ala Gln Val Thr Gly Ser Asn Thr Arg Lys His Ile Leu 
            580                 585                 590         


Gln Val Ser Thr Phe Gln Met Thr Ile Leu Met Leu Phe Asn Asn Arg 
        595                 600                 605             


Glu Lys Tyr Thr Phe Glu Glu Ile Gln Gln Glu Thr Asp Ile Pro Glu 
    610                 615                 620                 


Arg Glu Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Thr 
625                 630                 635                 640 


Gln Arg Val Leu Thr Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly 
                645                 650                 655     


His Ile Phe Thr Val Asn Asp Gln Phe Thr Ser Lys Leu His Arg Val 
            660                 665                 670         


Lys Ile Gln Thr Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg 
        675                 680                 685             


Lys Glu Thr Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu 
    690                 695                 700                 


Ala Ala Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn 
705                 710                 715                 720 


Val Leu Val Ala Glu Val Thr Gln Gln Leu Lys Ala Arg Phe Leu Pro 
                725                 730                 735     


Ser Pro Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu 
            740                 745                 750         


Tyr Leu Ala Arg Thr Pro Glu Asp Arg Lys Val Tyr Thr Tyr Val Ala 
        755                 760                 765             


<210>  109
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ser Arg Val Pro Ser Pro Pro Pro Pro Ala Glu Met Ser Ser Gly 
1               5                   10                  15      


Pro Val Ala Glu Ser Trp Cys Tyr Thr Gln Ile Lys Val Val Lys Phe 
            20                  25                  30          


Ser Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met 
        35                  40                  45              


Gly Glu Val Ile Lys Ser Ser Thr Phe Ser Ser Gly Ala Asn Asp Lys 
    50                  55                  60                  


Leu Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Glu Glu Ser 
65                  70                  75                  80  


Lys Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser 
                85                  90                  95      


Glu Val Arg Ala Lys Phe Lys Phe Ser Ile Leu Asn Ala Lys Gly Glu 
            100                 105                 110         


Glu Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly 
        115                 120                 125             


Lys Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp 
    130                 135                 140                 


Glu Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu 
145                 150                 155                 160 


Val Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly Gln Asn Thr Met 
                165                 170                 175     


Asn Met Val Lys Val Pro Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly 
            180                 185                 190         


Leu Trp Glu Asn Ser Arg Phe Thr Asp Cys Cys Leu Cys Val Ala Gly 
        195                 200                 205             


Gln Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg Ser Pro Val 
    210                 215                 220                 


Phe Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg 
225                 230                 235                 240 


Val Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu Met Met Cys 
                245                 250                 255     


Phe Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met Ala Asp Asp 
            260                 265                 270         


Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met 
        275                 280                 285             


Cys Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Ala Ala Glu 
    290                 295                 300                 


Ile Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu Lys Thr Gln 
305                 310                 315                 320 


Ala Val Asp Phe Ile Asn Tyr His Ala Ser Asp Val Leu Glu Thr Ser 
                325                 330                 335     


Gly Trp Lys Ser Met Val Val Ser His Pro His Leu Val Ala Glu Ala 
            340                 345                 350         


Tyr Arg Ser Leu Ala Ser Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg 
        355                 360                 365             


Lys Arg Leu Lys Gln Ser 
    370                 


