                         SEQUENCE LISTING

<110>  DiaMedica Inc.
       Alexander-Curtis, Michelle
       Williams, Mark
       Verdoorn, Todd A.
       Rick, Pauls
 
<120>  MODIFIED ULINASTATIN POLYPEPTIDES

<130>  DIAM-038/01WO 316251-2186

<150>  US 62/770,099
<151>  2018-11-20

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Val Leu Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val 
1               5                   10                  15      


Thr Glu Val Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala 
            20                  25                  30          


Gly Pro Cys Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser 
        35                  40                  45              


Met Ala Cys Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn 
    50                  55                  60                  


Asn Phe Val Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala 
65                  70                  75                  80  


Ala Cys Asn Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln 
                85                  90                  95      


Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr 
            100                 105                 110         


Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys 
        115                 120                 125             


Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu 
    130                 135                 140             


<210>  2
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - modified ulinastatin protein

<400>  2

Ala Val Leu Pro Gln Glu Glu Glu Gly Ala Gly Gly Gly Gln Leu Val 
1               5                   10                  15      


Thr Glu Val Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala 
            20                  25                  30          


Gly Pro Cys Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser 
        35                  40                  45              


Met Ala Cys Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn 
    50                  55                  60                  


Asn Phe Val Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala 
65                  70                  75                  80  


Ala Cys Asn Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln 
                85                  90                  95      


Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr 
            100                 105                 110         


Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys 
        115                 120                 125             


Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu 
    130                 135                 140             


<210>  3
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - modified ulinastatin domain

<400>  3

Ala Val Leu Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val 
1               5                   10                  15      


Thr Glu Val Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala 
            20                  25                  30          


Gly Pro Cys Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser 
        35                  40                  45              


Met Ala Cys Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn 
    50                  55                  60                  


Asn Phe Val Thr Glu Lys 
65                  70  


<210>  4
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - modified ulinastatin domain

<400>  4

Thr Val Ala Ala Cys Asn Leu Pro Ile Val Arg Gly Pro Cys Arg Ala 
1               5                   10                  15      


Phe Ile Gln Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu 
            20                  25                  30          


Phe Pro Tyr Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu 
        35                  40                  45              


Lys Glu Cys Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp Glu Glu 
    50                  55                  60                  


Leu Leu 
65      


<210>  5
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - ulinastatin-Fc fusion polypeptide

<400>  5

Ala Val Leu Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val 
1               5                   10                  15      


Thr Glu Val Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala 
            20                  25                  30          


Gly Pro Cys Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser 
        35                  40                  45              


Met Ala Cys Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn 
    50                  55                  60                  


Asn Phe Val Thr Glu Lys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
65                  70                  75                  80  


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                85                  90                  95      


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            100                 105                 110         


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met 
        115                 120                 125             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    130                 135                 140                 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
145                 150                 155                 160 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
                165                 170                 175     


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
            180                 185                 190         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        195                 200                 205             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    210                 215                 220                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
225                 230                 235                 240 


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                245                 250                 255     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            260                 265                 270         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        275                 280                 285             


Leu Ser Pro Gly Lys 
    290             


<210>  6
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - ulinastatin-Fc fusion polypeptide

<400>  6

Thr Val Ala Ala Cys Asn Leu Pro Ile Val Arg Gly Pro Cys Arg Ala 
1               5                   10                  15      


Phe Ile Gln Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu 
            20                  25                  30          


Phe Pro Tyr Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu 
        35                  40                  45              


Lys Glu Cys Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp Glu Glu 
    50                  55                  60                  


Leu Leu Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


Lys 
    


<210>  7
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - ulinastatin-Fc fusion polypeptide

<400>  7

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr 
    210                 215                 220                 


Val Ala Ala Cys Asn Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe 
225                 230                 235                 240 


Ile Gln Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe 
                245                 250                 255     


Pro Tyr Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys 
            260                 265                 270         


Glu Cys Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu 
        275                 280                 285             


Leu 
    


<210>  8
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Gly Ser Gly 
1               


<210>  9
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  10
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Thr Leu Ser Lys Ser 
            100     


<210>  11
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  12
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Pro Pro Pro Pro Pro 
1               5       


<210>  13
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser 
            100     


<210>  14
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  15
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  16
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro 
1               5                   10                  15      


Ala Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe 
            20                  25                  30          


Val Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala 
        35                  40                  45              


Gly Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His 
    50                  55                  60                  


Ser Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser 
65                  70                  75                  80  


Leu Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser 
                85                  90                  95      


Leu Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro 
            100                 105             


<210>  17
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser 
1               5                   10                  15      


Asp Pro Pro Glu Ala Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe 
            20                  25                  30          


Ser Pro Pro Asn Ile Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val 
        35                  40                  45              


Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser 
    50                  55                  60                  


Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Gln Pro Ala Thr Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg 
                85                  90                  95      


Thr Leu Leu Asn Ala Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp 
            100                 105                 110         


His Gly Pro Met Lys 
        115         


<210>  18
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
            100                 105         


<210>  19
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105             


<210>  20
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            100                 105                 110 


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  22
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10      


<210>  23
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  25
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  27
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  29
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  30
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110 


<210>  31
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  32
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  33
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  34
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  35
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  35

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


<210>  36
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
            20                  25                  30          


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
        35                  40                  45              


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
    50                  55                  60                  


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
65                  70                  75                  80  


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
                85                  90                  95      


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys 
            100                 105     


<210>  37
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg 
1               5                   10                  15      


Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr 
            20                  25                  30          


Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln 
        35                  40                  45              


Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro 
    50                  55                  60                  


Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu 
65                  70                  75                  80  


Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu 
                85                  90                  95      


Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly 
            100                 105                 110         


Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  38

Gly Ser Gly Ser 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  39

Gly Gly Ser Gly 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  40

Gly Gly Gly Ser 
1               


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  41

Gly Gly Gly Gly Ser 
1               5   


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  42

Gly Asn Gly Asn 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  43

Gly Gly Asn Gly 
1               


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  44

Gly Gly Gly Asn 
1               


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  45

Gly Gly Gly Gly Asn 
1               5   


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  46

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  47
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  47

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  48
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  48

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  49
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  49

Asp Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ala Ala Ala Arg Glu 
1               5                   10                  15      


Ala Ala Ala Arg Asp Ala Ala Ala Lys 
            20                  25  


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  50

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
1               5                   10                  


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  51

Asp Gly Gly Gly Ser 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  52

Thr Gly Glu Lys Pro 
1               5   


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  53

Gly Gly Arg Arg 
1               


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  54

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  55

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  56

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  57

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  58

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  59

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  60
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  60

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  61

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  62

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  63

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  64

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  65
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  65

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  66
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  66

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  67
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  67

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  68
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  68

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  69
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - self cleaving polypeptide site

<400>  69

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  70

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  71

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  72

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  73

Gly Arg Gly Asp 
1               


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  74

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  75

Gly Arg Gly Asp Ser 
1               5   


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  76

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  77
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  77

Ala Ala Pro Val 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  78

Ala Ala Pro Leu 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  79

Ala Ala Pro Phe 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  80

Ala Ala Pro Ala 
1               


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  81

Ala Tyr Leu Val 
1               


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  X = Any amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X = Any amino acid

<400>  82

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  X = Any amino acid

<400>  83

Leu Gly Pro Xaa 
1               


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X = Any amino acid

<400>  84

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  X = Any amino acid

<400>  85

Ala Pro Gly Leu Xaa 
1               5   


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X = Any amino acid

<400>  86

Pro Leu Gly Pro Asp Arg Xaa 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X = Any amino acid

<400>  87

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  88

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  89

Pro Leu Gly Cys His 
1               5   


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  90

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  91

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  92

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  93

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  94

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  95
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  95

Gly Asp Lys Pro 
1               


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  96

Gly Ser Asp Lys Pro 
1               5   


<210>  97
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  97

Ala Leu Ala Leu 
1               


<210>  98
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  98

Gly Phe Leu Gly 
1               


