                         SEQUENCE LISTING

<110>  OPKO Ireland Global Holdings, Ltd.
 
<120>  OXYNTOMODULIN PEPTIDE ANALOG FORMULATIONS

<130>  P-581901-PC

<150>  62/773,651
<151>  2018-11-30

<150>  62/821,382
<151>  2019-03-20

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Lys Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Gly Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala Xaa Xaa 
        35                  


<210>  2
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<400>  2

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Lys Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Gly Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala Cys Cys 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analogy


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Cys (20kD PEG)

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Cys (20kD PEG)

<400>  3

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Lys Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Gly Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala Xaa Xaa 
        35                  


<210>  4
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Active OXM

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  5
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Lys Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Gly Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analogy


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  1-Nal

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Ala Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala Xaa Xaa 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  1-Nal

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Ala Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala Cys Cys 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  1-Nal

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Cys(20 kDa PEG)

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Cys(20 kDa PEG)

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Ala Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala Xaa Xaa 
        35                  


<210>  9
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxyntomodulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  1-Nal

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Asn Xaa Ala Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  10
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  10

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  11

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Ala Trp Leu Lys Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<223>  4-imidazoacetyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Gly Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  13

Xaa Gly Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  14

Xaa Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Arg Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Ala Ala His Ser Gln Gly Thr 
            20                  25                  30          


Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp 
        35                  40          


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  15

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  16

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Arg Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Lys 
            20                  25                  


<210>  17
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  alpha-methyl-glutamic acid

<400>  17

Xaa Gly Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Xaa Leu Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  18
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  18

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  19
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  19

Xaa Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Arg Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Ala Ala His Ser Gln Gly Thr 
            20                  25                  30          


Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Lys 
        35                  40              


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  20

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Gly 
1               5                   10                  15      


Gly Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met 
            20                  25                  30          


Glu Glu Glu Ala Val Lys 
        35              


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivativ


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  alpha-methyl-glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  alpha-methyl-glutamic acid

<400>  21

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Xaa 
1               5                   10                  15      


Glu Ala Val Xaa Leu Phe Ile Glu Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  22
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  alpha-methyl-glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  alpha-methyl-glutamic acid

<400>  22

Xaa Gly Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Xaa Leu Phe Ile Xaa Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  23
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  alpha-methyl-glutamic acid

<400>  23

Xaa Gly Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Xaa Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  24
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  24

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Arg Gln Leu Glu Gly 
1               5                   10                  15      


Gly Gly His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Arg Gln Leu 
            20                  25                  30          


Glu Lys 
        


<210>  25
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  25

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Ile Arg Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  26
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  26

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Ile Arg Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  27
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  27

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Lys Leu Phe Ile Glu Trp Ile Arg Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  28
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  28

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Lys Leu Phe Ile Glu Trp Ile Arg Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  29
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  29

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Val Arg Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  desamino-histidyl

<400>  30

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  31

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  32

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Cys 
            20                  25                  30  


<210>  33
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  33

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Cys 
            20                  25                  30  


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  34

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Cys 
            20                  25                  30  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  35

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  36

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  37
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  d-serine

<400>  37

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  38
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<400>  38

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  39
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  d-serine

<400>  39

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  40
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4-imidazoacetyl

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  40

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Cys 
            20                  25                  30  


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  41

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ala Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Cys 
            20                  25                  30  


<210>  42
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oxyntomodulin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  42

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr Cys 
            20                  25                  30  


