                         SEQUENCE LISTING

<110>  National institute for biotechnology of the negev
       THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
 
<120>  VDAC INHIBITORS FOR TREATING AUTOIMMUNE DISEASES

<130>  NIBN-P-028-PCT

<150>  62/771,211
<151>  2018-11-26

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu 
            20                  25      


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (21)..(21)
<223>  wherein X is any amino acid other than Glycine

<220>
<221>  X
<222>  (23)..(23)
<223>  wherein X is any amino acid other than Glycine

<220>
<221>  X
<222>  (25)..(25)
<223>  wherein X is any amino acid other than Glycine

<400>  2

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys Xaa Tyr Xaa Phe Xaa 
            20                  25  


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (2)..(4)
<223>  wherein X is any amino acid

<400>  3

Gly Xaa Xaa Xaa Gly 
1               5   


<210>  4
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (21)..(21)
<223>  wherein X is any amino acid other than Glycine

<220>
<221>  X
<222>  (23)..(23)
<223>  wherein X is any amino acid other than Glycine

<400>  4

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys Xaa Tyr Xaa Phe 
            20                  


<210>  5
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (21)..(21)
<223>  wherein X is any amino acid other than Glycine

<220>
<221>  X
<222>  (23)..(23)
<223>  wherein X is any amino acid other than Glycine

<400>  5

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys Xaa Tyr Xaa 
            20              


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (21)..(21)
<223>  wherein X is any amino acid other than Glycine

<400>  6

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys Xaa Tyr 
            20          


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (21)..(21)
<223>  wherein X is any amino acid other than Glycine

<400>  7

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys Xaa 
            20      


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Lys 
            20  


<210>  10
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe 
            20                  


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly 
            20              


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr 
            20          


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly 
            20      


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethetic

<400>  14

Met Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythnetic

<400>  15

His Ala Ile Tyr Pro Arg His 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

His Arg Pro Tyr Ile Ala His 
1               5           


<210>  17
<211>  1993
<212>  DNA
<213>  Homo sapiens

<400>  17
attagcgcag ggacctccgg gccacagctc agagaatcgg aaggcctcct cccccttccc       60

gagcgctgcc actggggccg aggtttccag caagaacccg cgtgtccctg cgcacgcaca      120

cacggtgcac acgtcagtcc ggcgcctccc cgtgccccga ctcacgcagg tcctcccgcg      180

cgcccgcaac acgcccgcag gctcctgtgt ctgctgccgg ggcagcgggg cccggaaggc      240

agaagatggc tgtgccaccc acgtatgccg atcttggcaa atctgccagg gatgtcttca      300

ccaagggcta tggatttggc ttaataaagc ttgatttgaa aacaaaatct gagaatggat      360

tggaatttac aagctcaggc tcagccaaca ctgagaccac caaagtgacg ggcagtctgg      420

aaaccaagta cagatggact gagtacggcc tgacgtttac agagaaatgg aataccgaca      480

atacactagg caccgagatt actgtggaag atcagcttgc acgtggactg aagctgacct      540

tcgattcatc cttctcacct aacactggga aaaaaaatgc taaaatcaag acagggtaca      600

agcgggagca cattaacctg ggctgcgaca tggatttcga cattgctggg ccttccatcc      660

ggggtgctct ggtgctaggt tacgagggct ggctggccgg ctaccagatg aattttgaga      720

ctgcaaaatc ccgagtgacc cagagcaact ttgcagttgg ctacaagact gatgaattcc      780

agcttcacac taatgtgaat gacgggacag agtttggcgg ctccatttac cagaaagtga      840

acaagaagtt ggagaccgct gtcaatcttg cctggacagc aggaaacagt aacacgcgct      900

tcggaatagc agccaagtat cagattgacc ctgacgcctg cttctcggct aaagtgaaca      960

actccagcct gataggttta ggatacactc agactctaaa gccaggtatt aaactgacac     1020

tgtcagctct tctggatggc aagaacgtca atgctggtgg ccacaagctt ggtctaggac     1080

tggaatttca agcataaatg aatactgtac aattgtttaa ttttaaacta ttttgcagca     1140

tagctacctt cagaatttag tgtatctttt aatgttgtat gtctgggatg caagtattgc     1200

taaatatgtt agccctccag gttaaagttg attcagcttt aagatgttac ccttccagag     1260

gtacagaaga aacctatttc caaaaaaggt cctttcagtg gtagactcgg ggagaacttg     1320

gtggcccctt tgagatgcca ggtttctttt ttatctagaa atggctgcaa gtggaagcgg     1380

ataatatgta ggcactttgt aaattcatat tgagtaaatg aatgaaattg tgatttcctg     1440

agaatcgaac cttggttccc taaccctaat tgatgagagg ctcgctgctt gatggtgtgt     1500

acaaactcac ctgaatggga cttttttaga cagatcttca tgacctgttc ccaccccagt     1560

tcatcatcat ctcttttaca ccaaaaggtc tgcagggtgt ggtaactgtt tcttttgtgc     1620

cattttgggg tggagaaggt ggatgtgatg aagccaataa ttcaggactt attccttctt     1680

gtgttgtgtt tttttttggc ccttgcacca gagtatgaaa tagcttccag gagctccagc     1740

tataagcttg gaagtgtctg tgtgattgta atcacatggt gacaacactc agaatctaaa     1800

ttggacttct gttgtattct caccactcaa tttgtttttt agcagtttaa tgggtacatt     1860

ttagagtctt ccattttgtt ggaattagat cctccccttc aaatgctgta attaacaaca     1920

cttaaaaaac ttgaataaaa tattgaaacc tcatccttct tctgttgtct ttattaataa     1980

aatataaata aac                                                        1993


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
acacuaggca ccgagauua                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gggcuaugga uuuggcuua                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gcuuggucua ggacuggaa                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
aagcugaccu ucgauucau                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
gaaugacggg acagaguuu                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ucggaauagc agccaagua                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
cucuucugga uggcaagaa                                                    19


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
gaauagcagc caaguaucag                                                   20


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
uaagccaaau ccauagccc                                                    19


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
uuccaguccu agaccaagc                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
ugauacuugg cugcuauuc                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  gm

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  um

<400>  29
acacuaggca ccgagauua                                                    19


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  gm

<400>  30
uaaucucggu gccuagugu                                                    19


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
uaaucucggu gccuagugu                                                    19


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  um or uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  gm

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  um or uracil

<400>  32
gaauagcagc caaguaucag tt                                                22


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  um

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  gm

<400>  33
ugauacuugg cugcuauuct t                                                 21


<210>  34
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
gccgatcttg gcgcgtccgc cgcggatgtc ttcaccgcgg gctacggctt tg               52


<210>  35
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
caaagccgta gcccgcggtg aagacatccg cggcggacgc gccaagatcg gc               52


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
accagaatgc ctggaacaac                                                   20


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
atcagcacct tgaagaagtg t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ccaagtgctg ccgtcatttt c                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ggctcgcagg gatgatttca a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gacttcaaca gcaactccca c                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
tccaccaccc tgttgctgta                                                   20


<210>  42
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
ctgattacaa aagaagacat gacagac                                           27


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
aggcaaaacc aaagactcca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
caaggcaggt ttctgaggag                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
gacctggtca ccatcagcat                                                   20


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
ttcccagcag cacagaaac                                                    19


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
aaattccagg tgaaatggca                                                   20


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
ctttcctcat gatcctggta atgat                                             25


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
aatccaaaat ccttcctgtc cttc                                              24


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
ccctatggag atgacggaga                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
cccagtgctg gagaaattgt                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
ctatgacttc cccgtcctga                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
tcagaaattg ccgcttcttt                                                   20


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
ctagagctag agcctgcag                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
agttagtcac ggacaccag                                                    19


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
ggatgcctgg gagagaatcg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
tcgcctgctc ttcgaaactg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
acacagccaa gacatccttc                                                   20


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
caagtattca cccctgtcct g                                                 21


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
gagaggacca tgaagagga                                                    19


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
taaaccaacc agaccatgag                                                   20


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
actaatgtga atgacgggac a                                                 21


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
gcattgacgt tcttgccat                                                    19


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
aatctaccat cctccgtgaa acc                                               23


<210>  65
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
tcagtttagc tacccccaag tttaa                                             25


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
cccttcccca tttggtct                                                     18


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
tggtttcacg gaggatgg                                                     18


<210>  68
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
tcctccgtga aaccaacaa                                                    19


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
agcgagaaga ggggcatt                                                     18


<210>  70
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
ccccacaaac cccattacta aaccca                                            26


<210>  71
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
tttcatcatg cggagatgtt ggatgg                                            26


<210>  72
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Ala Ser Ala Ala Asp 
1               5                   10                  15      


Val Phe Thr Ala Gly Tyr Gly Phe Gly Leu 
            20                  25      


<210>  73
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
tcctccgtga aaccaacaac ccgcccacca atgcccctct tctcgctccg ggcccattaa       60

acttgggggt agctaaactg aaactttatc agacatctgg ttcttacttc agggccatca      120


<210>  74
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
tgatggccct gaagtaagaa ccagatgtct gataaagttt cagtttagct acccccaagt       60

ttaatgggcc cggagcgaga agaggggcat tggtgggcgg gttgttggtt tcacggagga      120


