                               SEQUENCE LISTING

<110> NANTKWEST, INC.
 
<120> IL-2 DEPENDENT NK-92 CELLS WITH STABLE FC RECEPTOR EXPRESSION

<130> 104066-1154550 (9910WO)

<140>
<141>

<150> 62/771,479
<151> 2018-11-26

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 254
<212> PRT
<213> Homo sapiens

<400> 1
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210> 2
<211> 765
<212> DNA
<213> Homo sapiens

<400> 2
atgtggcagc tgctgctgcc tacagctctc ctgctgctgg tgtccgccgg catgagaacc       60

gaggatctgc ctaaggccgt ggtgttcctg gaaccccagt ggtacagagt gctggaaaag      120

gacagcgtga ccctgaagtg ccagggcgcc tacagccccg aggacaatag cacccagtgg      180

ttccacaacg agagcctgat cagcagccag gccagcagct acttcatcga cgccgccacc      240

gtggacgaca gcggcgagta tagatgccag accaacctga gcaccctgag cgaccccgtg      300

cagctggaag tgcacatcgg atggctgctg ctgcaggccc ccagatgggt gttcaaagaa      360

gaggacccca tccacctgag atgccactct tggaagaaca ccgccctgca caaagtgacc      420

tacctgcaga acggcaaggg cagaaagtac ttccaccaca acagcgactt ctacatcccc      480

aaggccaccc tgaaggactc cggctcctac ttctgcagag gcctcgtggg cagcaagaac      540

gtgtccagcg agacagtgaa catcaccatc acccagggcc tggccgtgtc taccatcagc      600

agctttttcc cacccggcta ccaggtgtcc ttctgcctcg tgatggtgct gctgttcgcc      660

gtggacaccg gcctgtactt cagcgtgaaa acaaacatca gaagcagcac ccgggactgg      720

aaggaccaca agttcaagtg gcggaaggac ccccaggaca agtga                      765


<210> 3
<211> 160
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ER IL-2 sequence"

<400> 3
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


<210> 4
<211> 483
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ER IL-2 sequence"

<400> 4
atgtaccgga tgcagctgct gagctgtatc gccctgtctc tggccctcgt gaccaacagc       60

gcccctacca gcagcagcac caagaaaacc cagctgcagc tggaacatct gctgctggac      120

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      180

accttcaagt tctacatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      240

gaggaactga agcccctgga agaagtgctg aacctggccc agagcaagaa cttccacctg      300

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa aggcagcgag      360

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      420

tggatcacct tctgccagag catcatcagc accctgaccg gctccgagaa ggacgagctg      480

tga                                                                    483


<210> 5
<211> 5491
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct       60

gacgtcgacg gatcgggaga tctcccgatc ccctatggtg cactctcagt acaatctgct      120

ctgatgccgc atagttaagc cagtatctgc tccctgcttg tgtgttggag gtcgctgagt      180

agtgcgcgag caaaatttaa gctacaacaa ggcaaggctt gaccgacaat tgcatgaaga      240

atctgcttag ggttaggcgt tttgcgctgc ttcgggatcc gctgaccaaa agagcaccaa      300

aggcgccctg accttcagcc cctacctgcg ctccggtgcc cgtcagtggg cagagcgcac      360

atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag      420

aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga      480

gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg      540

gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg gcctctttac      600

gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg tgattcttga      660

tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc      720

ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg      780

gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg      840

atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct      900

gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg      960

cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc     1020

tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg     1080

ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg     1140

ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc     1200

acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga     1260

gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt     1320

aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga     1380

agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg     1440

atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt     1500

gtcgtgataa tacgactcac tatagggaga cccaagctgg aattcgccac catgtggcag     1560

ctgctgctgc ctacagctct cctgctgctg gtgtccgccg gcatgagaac cgaggatctg     1620

cctaaggccg tggtgttcct ggaaccccag tggtacagag tgctggaaaa ggacagcgtg     1680

accctgaagt gccagggcgc ctacagcccc gaggacaata gcacccagtg gttccacaac     1740

gagagcctga tcagcagcca ggccagcagc tacttcatcg acgccgccac cgtggacgac     1800

agcggcgagt atagatgcca gaccaacctg agcaccctga gcgaccccgt gcagctggaa     1860

gtgcacatcg gatggctgct gctgcaggcc cccagatggg tgttcaaaga agaggacccc     1920

atccacctga gatgccactc ttggaagaac accgccctgc acaaagtgac ctacctgcag     1980

aacggcaagg gcagaaagta cttccaccac aacagcgact tctacatccc caaggccacc     2040

ctgaaggact ccggctccta cttctgcaga ggcctcgtgg gcagcaagaa cgtgtccagc     2100

gagacagtga acatcaccat cacccagggc ctggccgtgt ctaccatcag cagctttttc     2160

ccacccggct accaggtgtc cttctgcctc gtgatggtgc tgctgttcgc cgtggacacc     2220

ggcctgtact tcagcgtgaa aacaaacatc agaagcagca cccgggactg gaaggaccac     2280

aagttcaagt ggcggaagga cccccaggac aagtgaaatt ccgcccctct cccccccccc     2340

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2400

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2460

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2520

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2580

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2640

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2700

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2760

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca     2820

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     2880

acgtggtttt cctttgaaaa acacgataac cgccaccatg taccggatgc agctgctgag     2940

ctgtatcgcc ctgtctctgg ccctcgtgac caacagcgcc cctaccagca gcagcaccaa     3000

gaaaacccag ctgcagctgg aacatctgct gctggacctg cagatgatcc tgaacggcat     3060

caacaactac aagaacccca agctgacccg gatgctgacc ttcaagttct acatgcccaa     3120

gaaggccacc gaactgaaac atctgcagtg cctggaagag gaactgaagc ccctggaaga     3180

agtgctgaac ctggcccaga gcaagaactt ccacctgagg cccagggacc tgatcagcaa     3240

catcaacgtg atcgtgctgg aactgaaagg cagcgagaca accttcatgt gcgagtacgc     3300

cgacgagaca gctaccatcg tggaatttct gaaccggtgg atcaccttct gccagagcat     3360

catcagcacc ctgaccggct ccgagaagga cgagctgtga gcggccgccc gctgatcagc     3420

ctcgaacgag atttcgattc caccgccgcc ttctatgaaa ggttgggctt cggaatcgtt     3480

ttccgggacg ccggctggat gatcctccag cgcggggatc tcatgctgga gttcttcgcc     3540

caccccaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat     3600

ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat     3660

gtatcttatc atgtctgtgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3720

ggctctaggg ggtatccccg gatcctgagc aaaaggccag caaaaggcca ggaaccgtaa     3780

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa     3840

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     3900

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc     3960

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag     4020

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga     4080

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc     4140

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac     4200

agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg     4260

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca     4320

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     4380

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     4440

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt     4500

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag     4560

ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat     4620

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc     4680

cagtgctgca atgataccgc gagaaccacg ctcaccggct ccagatttat cagcaataaa     4740

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca     4800

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa     4860

cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt     4920

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc     4980

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact     5040

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc     5100

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg     5160

ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct     5220

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc     5280

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag     5340

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac     5400

acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg     5460

ttattgtctc atgagcggat acatatttga a                                    5491


<210> 6
<211> 8928
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggaggcg tggcctgggc gggactgggg agtggcgagc      420

cctcagatcc tgcatataag cagctgcttt ttgcctgtac tgggtctctc tggttagacc      480

agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa      540

gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga      600

gatccctcag acccttttag tcagtgtgga aaatctctag cagtggcgcc cgaacaggga      660

cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc ttgctgaagc      720

gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg      780

aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga gaattagatc      840

gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat taaaacatat      900

agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt tagaaacatc      960

agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag gatcagaaga     1020

acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa ggatagagat     1080

aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa gtaagaaaaa     1140

agcacagcaa gcagcaggat cttcagacct ggaaattccc tacaatcccc aaagtcaagg     1200

agtagtagaa tctatgaata aagaattaaa gaaaattata ggacaggtaa gagatcaggc     1260

tgaacatctt aagacagcag tacaaatggc agtattcatc cacaatttta aaagaaaagg     1320

ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca     1380

aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt attacaggga     1440

cagcagaaat ccactttgga aaggaccagc aaagctcctc tggaaaggtg aaggggcagt     1500

agtaatacaa gataatagtg acataaaagt agtgccaaga agaaaagcaa agatcattag     1560

ggattatgga aaacagatgg caggtgatga ttgtgtggca agtagacagg atgaggatta     1620

gaacatggaa aagtttagta aaacaccata aggaggagat atgagggaca attggagaag     1680

tgaattatat aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc     1740

aaagagaaga gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg     1800

gttcttggga gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc     1860

cagacaatta ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc     1920

gcaacagcat ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct     1980

ggctgtggaa agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa     2040

actcatttgc accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca     2100

gatttggaat cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt     2160

aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt     2220

ggaattagat aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta     2280

tataaaatta ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt     2340

actttctata gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct     2400

cccaaccccg aggggaccga gctcaagctt cgaacgcgtt aacgggccca gcttcgataa     2460

aataaaagat tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt     2520

ttggcaagct agcttaagta acgccatttt gcaaggcatg gaaaatacat aactgagaat     2580

agagaagttc agatcaaggt taggaacaga gagacagcag aatatgggcc aaacaggata     2640

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg     2700

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     2760

aaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2820

cgcttctgct ccccgagctc aataaaagag cccacaaccc ctcactcggc gcgccagtcc     2880

tccgatagac tgcgtcgccc gggtaccggt gccaccatgg actggatctg gcgcatcctc     2940

ttcctcgtcg gcgctgctac cggcgctcat tcggcccagc cggccgacat ccagatgaca     3000

cagactacat cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca     3060

agtcaggaca ttagtaaata tttaaattgg tatcagcaaa aaccagatgg aactgttaaa     3120

ctcctgatct accatacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt     3180

gggtctggaa cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact     3240

tacttttgcc aacagggtaa tacgcttccg tacacgttcg gaggggggac caagctggag     3300

ctgaaacgtg gtggtggtgg ttctggtggt ggtggttctg gcggcggcgg ctccggtggt     3360

ggtggatccg aggtgcagct gcagcagtct ggacctggcc tggtggcgcc ctcacagagc     3420

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt     3480

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca     3540

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa     3600

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa     3660

cattattact acggtggtag ctatgctatg gactactggg gccaagggac cacggtcacc     3720

gtctcctcgg cggccgctct agaacagaaa ctgatctccg aagaagatct gaacctagag     3780

atcagcaact cggtgatgta cttcagttct gtcgtgccag tccttcagaa agtgaactct     3840

actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag     3900

ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttg     3960

ctagaggatc ccaaactctg ctacttgcta gatggaatcc tcttcatcta cggagtcatc     4020

atcacagccc tgtacctgag agcaaaattc agcaggagtg cagagactgc tgccaacctg     4080

caggacccca accagctcta caatgagctc aatctagggc gaagagagga atatgacgtc     4140

ttggagaaga agcgggctcg ggatccagag atgggaggca aacagcagag gaggaggaac     4200

ccccaggaag gcgtatacaa tgcactgcag aaagacaaga tggcagaagc ctacagtgag     4260

atcggcacaa aaggcgagag gcggagaggc aaggggcacg atggccttta ccagggtctc     4320

agcactgcca ccaaggacac ctatgatgcc ctgcatatgc agaccctggc ccctcgctaa     4380

ccgcggacat gtacagagct cgagcgggat caattccgcc ccccccctaa cgttactggc     4440

cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg     4500

ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct     4560

aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca     4620

gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg     4680

aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct     4740

gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa     4800

tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt     4860

atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa     4920

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgataatacc     4980

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     5040

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac     5100

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc     5160

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag     5220

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc     5280

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg     5340

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac     5400

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac     5460

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc     5520

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     5580

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc     5640

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa     5700

agcggccgca tcgatgccgt atacggtacc tttaagacca atgacttaca aggcagctgt     5760

agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaaag     5820

aagacaagat ctgctttttg cctgtactgg gtctctctgg ttagaccaga tctgagcctg     5880

ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tcagctgctc     5940

gagctagcag atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     6000

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     6060

ttgtgtctct cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag     6120

tatttggttt agagtttggc aacatatgcc atatgctggc tgccatgaac aaaggtggct     6180

ataaagaggt catcagtata tgaaacagcc ccctgctgtc cattccttat tccatagaaa     6240

agccttgact tgaggttaga ttttttttat attttgtttt gtgttatttt tttctttaac     6300

atccctaaaa ttttccttac atgttttact agccagattt ttcctcctct cctgactact     6360

cccagtcata gctgtccctc ttctcttatg aagatccctc gacctgcagc ccaagcttgg     6420

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca     6480

acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca     6540

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagcgga     6600

tccgcatctc aattagtcag caaccatagt cccgccccta actccgccca tcccgcccct     6660

aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc     6720

agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg     6780

aggcctaggc ttttgcaaaa agctaacttg tttattgcag cttataatgg ttacaaataa     6840

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     6900

ttgtccaaac tcatcaatgt atcttatcat gtctggatcc gctgcattaa tgaatcggcc     6960

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     7020

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     7080

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     7140

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     7200

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     7260

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     7320

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct caatgctcac     7380

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     7440

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     7500

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     7560

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     7620

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     7680

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     7740

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     7800

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     7860

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     7920

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     7980

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     8040

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     8100

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     8160

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     8220

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     8280

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     8340

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     8400

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     8460

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     8520

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     8580

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     8640

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     8700

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     8760

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     8820

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     8880

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctg                  8928


<210> 7
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
cgtaactacc gtgaattcat ctacaagcat gcattgtagt agcggccgca tcgatgccgt       60

ataccgtac                                                               69


<210> 8
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
ggtatacggc atcgatgcgg ccgctactac aatgcatgct tgtagatgaa ttcacggtag       60

ttacggtac                                                               69


<210> 9
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 9
acttcaggta ccggtgccac catgtggcag ctgctgctg                              39


<210> 10
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 10
taggttgcgg ccgctcactt gtcctggggg tccttc                                 36


<210> 11
<211> 6908
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggaggcg tggcctgggc gggactgggg agtggcgagc      420

cctcagatcc tgcatataag cagctgcttt ttgcctgtac tgggtctctc tggttagacc      480

agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa      540

gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga      600

gatccctcag acccttttag tcagtgtgga aaatctctag cagtggcgcc cgaacaggga      660

cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc ttgctgaagc      720

gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg      780

aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga gaattagatc      840

gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat taaaacatat      900

agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt tagaaacatc      960

agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag gatcagaaga     1020

acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa ggatagagat     1080

aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa gtaagaaaaa     1140

agcacagcaa gcagcaggat cttcagacct ggaaattccc tacaatcccc aaagtcaagg     1200

agtagtagaa tctatgaata aagaattaaa gaaaattata ggacaggtaa gagatcaggc     1260

tgaacatctt aagacagcag tacaaatggc agtattcatc cacaatttta aaagaaaagg     1320

ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca     1380

aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt attacaggga     1440

cagcagaaat ccactttgga aaggaccagc aaagctcctc tggaaaggtg aaggggcagt     1500

agtaatacaa gataatagtg acataaaagt agtgccaaga agaaaagcaa agatcattag     1560

ggattatgga aaacagatgg caggtgatga ttgtgtggca agtagacagg atgaggatta     1620

gaacatggaa aagtttagta aaacaccata aggaggagat atgagggaca attggagaag     1680

tgaattatat aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc     1740

aaagagaaga gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg     1800

gttcttggga gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc     1860

cagacaatta ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc     1920

gcaacagcat ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct     1980

ggctgtggaa agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa     2040

actcatttgc accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca     2100

gatttggaat cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt     2160

aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt     2220

ggaattagat aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta     2280

tataaaatta ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt     2340

actttctata gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct     2400

cccaaccccg aggggaccga gctcaagctt cgaacgcgtt aacgggccca gcttcgataa     2460

aataaaagat tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt     2520

ttggcaagct agcttaagta acgccatttt gcaaggcatg gaaaatacat aactgagaat     2580

agagaagttc agatcaaggt taggaacaga gagacagcag aatatgggcc aaacaggata     2640

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg     2700

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     2760

aaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2820

cgcttctgct ccccgagctc aataaaagag cccacaaccc ctcactcggc gcgccagtcc     2880

tccgatagac tgcgtcgccc gggtaccggt gccaccatgt ggcagctgct gctgcctaca     2940

gctctcctgc tgctggtgtc cgccggcatg agaaccgagg atctgcctaa ggccgtggtg     3000

ttcctggaac cccagtggta cagagtgctg gaaaaggaca gcgtgaccct gaagtgccag     3060

ggcgcctaca gccccgagga caatagcacc cagtggttcc acaacgagag cctgatcagc     3120

agccaggcca gcagctactt catcgacgcc gccaccgtgg acgacagcgg cgagtataga     3180

tgccagacca acctgagcac cctgagcgac cccgtgcagc tggaagtgca catcggatgg     3240

ctgctgctgc aggcccccag atgggtgttc aaagaagagg accccatcca cctgagatgc     3300

cactcttgga agaacaccgc cctgcacaaa gtgacctacc tgcagaacgg caagggcaga     3360

aagtacttcc accacaacag cgacttctac atccccaagg ccaccctgaa ggactccggc     3420

tcctacttct gcagaggcct cgtgggcagc aagaacgtgt ccagcgagac agtgaacatc     3480

accatcaccc agggcctggc cgtgtctacc atcagcagct ttttcccacc cggctaccag     3540

gtgtccttct gcctcgtgat ggtgctgctg ttcgccgtgg acaccggcct gtacttcagc     3600

gtgaaaacaa acatcagaag cagcacccgg gactggaagg accacaagtt caagtggcgg     3660

aaggaccccc aggacaagtg agcggccgca tcgatgccgt ataccgtacc tttaagacca     3720

atgacttaca aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa     3780

gggctaattc actcccaaag aagacaagat ctgctttttg cctgtactgg gtctctctgg     3840

ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct     3900

caataaagct tcagctgctc gagctagcag atctttttcc ctctgccaaa aattatgggg     3960

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     4020

caatagtgtg ttggaatttt ttgtgtctct cactcggaag gacatatggg agggcaaatc     4080

atttaaaaca tcagaatgag tatttggttt agagtttggc aacatatgcc atatgctggc     4140

tgccatgaac aaaggtggct ataaagaggt catcagtata tgaaacagcc ccctgctgtc     4200

cattccttat tccatagaaa agccttgact tgaggttaga ttttttttat attttgtttt     4260

gtgttatttt tttctttaac atccctaaaa ttttccttac atgttttact agccagattt     4320

ttcctcctct cctgactact cccagtcata gctgtccctc ttctcttatg aagatccctc     4380

gacctgcagc ccaagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta     4440

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc     4500

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg     4560

aaacctgtcg tgccagcgga tccgcatctc aattagtcag caaccatagt cccgccccta     4620

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga     4680

ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag     4740

tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctaacttg tttattgcag     4800

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     4860

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatcc     4920

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     4980

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     5040

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     5100

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     5160

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     5220

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     5280

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     5340

ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     5400

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     5460

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     5520

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     5580

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt     5640

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     5700

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     5760

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     5820

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     5880

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     5940

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     6000

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     6060

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     6120

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     6180

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat     6240

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     6300

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     6360

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     6420

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     6480

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     6540

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     6600

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     6660

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     6720

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     6780

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     6840

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     6900

gccacctg                                                              6908


<210> 12
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Endoplasmic reticulum retention signal sequence"

<400> 12
Lys Asp Glu Leu 
1               

