                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc.
       The U.S.A., as represented by the Secretary, Department of 
       Health and Human Services
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-CD38 
       IMMUNOTHERAPY

<130>  42449-0033WO1

<140>  PCT/US2019/063761
<141>  2019-11-27

<150>  US 62/773,940
<151>  2018-11-30

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3801

<400>  1
gaagtgcaat tggtccaaag cggtgcagaa gtcaagaaac ctggttcgag cgtgaaagtg       60

tcctgcaagg cctctggcgg caccttctca tcctacgcca ttagctgggt ccgccaagcc      120

ccgggccagg gacttgagtg gatgggcgga atcatcccta tcttcgggac cgccaattac      180

gcccagaagt tccagggccg cgtgaccatc accgcggaca agtccacatc aaccgcctat      240

atggagctct cgtcgctgag atcagaggac actgctgtct actactgtgc gagggcccca      300

tacgacgatg cattcgacat ctggggacag ggtaccatgg tcactgtgtc cagcgggggc      360

ggaggctccg gggggggcgg atcggggggc ggcggatcca acttcatgct gacccagccg      420

cactcggtgt cagagagccc cggaaagact gtgaccatta gctgcacccg gtccagcgga      480

agcatcgcct ccaactacgt gcagtggtac cagcagcggc cgggctccgc gccgaccact      540

gtgatctacg aagataacca gcgcccctcc ggtgtccctg gacggttctc cggatccatt      600

gacacctcgt ccaactccgc ctcgctgacg atctccggac tggagactga agatgaagct      660

gtgtactact gccaatccta cgactccgga tttccctacg ccgtgttcgg tggcgggacc      720

cagctcaccg tgctggga                                                    738


<210>  2
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3801

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
    130                 135                 140                 


Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly 
145                 150                 155                 160 


Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
                165                 170                 175     


Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
            180                 185                 190         


Pro Gly Arg Phe Ser Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser 
        195                 200                 205             


Leu Thr Ile Ser Gly Leu Glu Thr Glu Asp Glu Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Ser Tyr Asp Ser Gly Phe Pro Tyr Ala Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Gln Leu Thr Val Leu Gly 
                245     


<210>  3
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3802

<400>  3
gaagtgcaac tcgtcgaatc tggtggagga tccgtgcagc ctggtggaag cctgagactg       60

tcgtgtgccg cctccgagtt caccttctcc tcgtactgga tgcactgggt cagacaggcg      120

cccggaaagg gcctggaatg ggtggccgtg atctcatacg acggcgcgaa gaagtactac      180

gccgattccg tgaagggccg ctttaccatt tcccgggaca attcaaagaa caccctctac      240

cttcaaatga actccctgag ggccgaggat actgcagtct actactgcgc tcgggatgac      300

gggagcgggg gcttcgacta ctggggacag ggaaccctcg tgactgtgtc atccggtggc      360

ggcggctccg gaggcggcgg ttccgggggg gggggatccg acatcgtgat gacgcacact      420

cctctgtcgc tgtccgtgac ccccggccag cctgcctcaa tctcgtgcaa gagctcccag      480

tcgctgctgc atagcgatgg aaagacctac ctgtattggt accttcaaaa gccgggacag      540

ccgccgcagt tgctgatcta tgaagtcagc aaccgcttct cgggagtgcc cgaccgctac      600

tccggctcgg ggagcggaac cgacttcacc ctgaaaattt cccgggtcga ggcagaggac      660

gtgggagtgt actactgcat gcaaagcatt cagttgccac tgactttcgg tggaggaacc      720

aagctcgaaa tcaaa                                                       735


<210>  4
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3802

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ala Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr His Thr Pro Leu Ser Leu 
    130                 135                 140                 


Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Asp Arg Tyr Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Met Gln Ser Ile Gln Leu Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  5
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3803

<400>  5
gaagtgcaat tggtgcagag cggtggagga cttgtgaaac ctggtggatc cctgagactt       60

tcctgtgccg cttcgggctt caccttctcg gactactaca tgtcctggat tcgccaggcc      120

cctggaaagg gactggaatg ggtgtcatac atcagctcct ccggttccac catctactat      180

gccgattccg tgaagggcag attcaccatc tcgcgcgaca acgccaagaa cactctctat      240

ctgcaaatga actcactgcg ggctgaggac accgcggtct actactgcgc ccgggacctc      300

agcggaaagt ccagcggatg gtcccattac ttcgattact ggggacaggg aaccctggtc      360

accgtgtcca gcggcggggg gggctcgggt ggcggcggct ccggcggcgg cgggagcaac      420

ttcatgctga ctcagcccca ctccgtgtcc gagagcccgg gaaagaccgt gactatttcg      480

tgcacacggt cctccgggag cattgcgaac aactacgtgc agtggtacca gcagcggccc      540

gatagggccc caaccactgt gatctacgaa gatgaccagc ggccgtctgg agtcccggac      600

cgcttctcgg ggtccatcga ctcatcatcc aattccgcat cgctgacgat cagcggactg      660

aagatcgagg acgaagccga ttactactgc cagtcctacg acggcaccaa ctgggtcttt      720

gggggtggaa ccaagctgac tgtgctcgga                                       750


<210>  6
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3803

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Lys Ser Ser Gly Trp Ser His Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr 
    130                 135                 140                 


Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn Tyr Val Gln Trp Tyr 
                165                 170                 175     


Gln Gln Arg Pro Asp Arg Ala Pro Thr Thr Val Ile Tyr Glu Asp Asp 
            180                 185                 190         


Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser 
        195                 200                 205             


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Ile Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr Asn Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250 


<210>  7
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3804

<400>  7
gaagtgcaac ttgtcgaaag cggtggaggt cttgtccaac ctggtcgctc cctgaggctc       60

tcgtgtgccg cgagcggatt caccttctca tcgtacgcta tgtcctgggt cagacaggct      120

cctggaaagg gcctggaatg ggtggccgtg atctcctacg acggcagcaa caagtattac      180

gccgactcag tgaagggccg gttcaccatt tcccgggaca acagcaagaa caccctgtac      240

ttgcaaatga actccctgcg ggccgaggat accgcggtgt actactgcgc ccacctccgc      300

tttggatacg gaatggatgt ctggggacag ggaactaccg tgaccgtgtc gtccgggggg      360

gggggaagcg gcggcggggg atcgggtggc ggcggatccc agactgtggt cacccaagag      420

ccttcactga ccgtgtcccc gggtggcacc gtgacgctga cttgcgcgtc atctaccggg      480

gccgtgacct cggaccacta cccctgctgg ttccagcaga aacccggaca tccaccgaga      540

gccctggtgt actccactga caccatccac tcctggactc cggcccggtt ctccggaagc      600

ctcctgggcg ggaaggccgc actgacagtg tccggagtgc agcccgagga tgaagccgac      660

tactactgtc tgctctacta tgggggagca cgcgtgttcg gtggcggcac tcagctgacc      720

gtgctggga                                                              729


<210>  8
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3804

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala His Leu Arg Phe Gly Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Ser Asp His Tyr Pro Cys Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


His Pro Pro Arg Ala Leu Val Tyr Ser Thr Asp Thr Ile His Ser Trp 
            180                 185                 190         


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Val Ser Gly Val Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu 
    210                 215                 220                 


Leu Tyr Tyr Gly Gly Ala Arg Val Phe Gly Gly Gly Thr Gln Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  9
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3806

<400>  9
caagtgcaac tcgtccaatc cggagctgaa gtcaagaagc caggatcttc cgtgaaagtg       60

tcgtgcaagg cctccggggg aacattctcc tcatatgcga tcagctgggt ccgccaggct      120

ccgggacagg gcttggagtg gatgggtatc attaaccctt cgggcggctc aactagctac      180

gcccagaagt tccagggcag agtgaccatg accagggaca ccagcacttc gacggtgtac      240

atggaactgt cctcactgcg gtccgaggac accgccgtgt actactgcgc ccgggagtat      300

tcctcctccc gcgtggacgc cttcgatatc tggggacagg gtaccatggt cactgtgtcg      360

tccggcggcg gcggaagcgg gggtggcggg agcggtggcg gcggatccag ctacgaactc      420

acccagccgc cgtcagtgtc cgtgagcccg ggacagaccg caaccattac ttgttccggg      480

gatgacctgg gatccaaata cgtgtgctgg taccaacaga agcctggtca ctcgcccgtg      540

ctgatcatct acgacgactc agaccggccc agcggcatcc ccgagagatt ttccggatcc      600

aacagcggaa acaccgccac tctgactatt tcgcgcgtcg aggccggcga cgaagcggat      660

tactactgcc aagtctggga cagctcctcg gatcatgccg tgttcggggg cggaacccag      720

cttaccgtgc tgggg                                                       735


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3806

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Ser Ser Arg Val Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Val Ser Val Ser Pro Gly Gln Thr Ala Thr Ile Thr Cys Ser Gly 
145                 150                 155                 160 


Asp Asp Leu Gly Ser Lys Tyr Val Cys Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


His Ser Pro Val Leu Ile Ile Tyr Asp Asp Ser Asp Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln 
    210                 215                 220                 


Val Trp Asp Ser Ser Ser Asp His Ala Val Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu Gly 
                245 


<210>  11
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3808

<400>  11
gaagtgcagt tggtggagag cggtggagga cttgtgcaac ctggtggatc cctgagattg       60

tcgtgtgccg cctccggttt caccttctcc tcgtactgga tgagctgggt ccgccaggca      120

cccgggaagg gactggaatg ggtggcggac attaaggatg acggctccga gcggtactac      180

gtggactccg tgaagggccg gttcactatc tcaagagaca atgccaagaa cagcctgtac      240

ctccaaatga actcgctgcg ggccgaggat accgcagtgt attactgcgc ccgcgacgtg      300

tgggctggga tggatgtctg gggccagggg accactgtca ctgtgtctag cgggggcggc      360

ggaagcggcg gcggcggatc cggtggtggc ggaagcgaca ttcagctgac ccagtcccca      420

tcattcctgt ccgcctccgt gggcgacagg gtcactatca cttgccaagc cagccaggac      480

atctccaact acctgaactg gtaccagcag aagcctggaa aagctccgaa gctcctcatc      540

tacgacgcct cgaacctcga aaccggagtg ccctcacggt tttccggatc gggatcgggg      600

accgatttct ccttcaccat ttcatccctg caacccgagg acatcgcgac ctactactgc      660

caacagacat actccccgcc gattacgttc ggacagggaa cccgcctgga aatcaag         717


<210>  12
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3808

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Asp Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Trp Ala Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
145                 150                 155                 160 


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr 
    210                 215                 220                 


Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 


<210>  13
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide

<400>  13
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide

<400>  14

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  15
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3809

<400>  15
caagtccaac tcgtccagtc cggtgccgaa gtcaagaagc ctggctcatc cgtgaaagtg       60

tcctgcaaag catcgggcgg aaccttctcc tcctatgcca tttcctgggt ccgccaggca      120

ccgggccagg gtctggagtg gatgggcggg attatcccta tcttcggaac tgccaaccac      180

gcccaaaagt tccagggacg cgtgaccatt accgccgatg aatcaacctc aaccgcctac      240

atggaactgt ccagcttgag gtccgaggac accgccgtgt actactgcgc gttcatgatg      300

gtgccggagt actactttga ctactggggc cagggaaccc ttgtgaccgt gtcgtccggt      360

ggtggcggat ccgggggggg gggatctggg ggcggcggaa gcgatatcca gatgacccag      420

tcgccatcga gcctgtccgc ttccgtgggc gacagagtga cgatcacttg ccgggcttca      480

caaggcatca gaaatgacct gggctggtat cagcagaagc ccggagaagc gcccaagcgg      540

ctgatctacg cggccagcac cctgcaaaac ggagtgcctt cgcggttctc cgggagcggc      600

tccggaactg acttcactct gactattaac agcctccagc ccgaggattt cgccacatac      660

tactgtcagc agtacaacag ctacccgtac accttcggac agggaactaa gctcgaaatc      720

aag                                                                    723


<210>  16
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3809

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Met Met Val Pro Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Glu 
                165                 170                 175     


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Gln Asn Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  17
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3810

<400>  17
aaagtgcaac tccaagaaag cggccccgga cttgtcaaac cgtcccagac tctctccctg       60

acctgtgccg tcagcggtgg ctcaatttcg agcggtggct actactggtc ctggatcagg      120

cagcatccgg gaaagggctt ggagtggatt ggatacatct actactccgg gtccacctac      180

tacaatccct cgctgaagtc gagagtcacc atcagcgtgg acacctccaa gaaccagttt      240

agcctgaagc tgtcctcagt gaccgcagct gacaccgccg tgtactactg cgcccgcggc      300

ggagtgatgg gcggagactt cgactactgg ggacagggaa ccctggtcac tgtgtccagc      360

gggggggggg gatccggcgg cggcggttcc ggtggcggag ggtcccagtc agtgctgact      420

cagccacctt ccgtgtctgt gtcgcccgga caaaccgcca gcatcacgtg ctccggcgac      480

aacctcggtg atcactatgt gtgctggtac caacagcggc cggggcagtc accggtgctg      540

attatgtacg aggatactaa gcgcccttcc ggaatccctg accggttctc gggaagcaac      600

tccggaaaca ccgccaccct gaccatctcc ggaacccaga caatggatga agcggactac      660

tattgcgtgg cgtgggacga ttcgctgtcc ggctgggtgt tcggcggggg aactcagctg      720

actgtgctcg ga                                                          732


<210>  18
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3810

<400>  18

Lys Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Val Met Gly Gly Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp 
145                 150                 155                 160 


Asn Leu Gly Asp His Tyr Val Cys Trp Tyr Gln Gln Arg Pro Gly Gln 
                165                 170                 175     


Ser Pro Val Leu Ile Met Tyr Glu Asp Thr Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Thr Gln Thr Met Asp Glu Ala Asp Tyr Tyr Cys Val Ala 
    210                 215                 220                 


Trp Asp Asp Ser Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  19
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3811

<400>  19
caactccaac tccaagaatc tggaccaggc ctcgtgaagc cctcccaaac tctgtccctg       60

acctgtaccg tgtcgggtgg aagcatttcg agcggtggat actactggtc ctggatcagg      120

cagcatcctg gaaagggact ggagtggatt gggtacatct actactccgg ctcaacctac      180

tacaacccgt ccttgaaatc gcgcgtgacg atctccgtgg acacttcaaa gaaccagttc      240

agcctgaagc tttcctccgt gaccgcggcc gatacagcgg tgtactactg cgctcgggat      300

cagagcgtgg ccgaccctgg tggcggctac tactactacg gaatggatgt ctggggacag      360

ggaaccaccg tgactgtgtc cagcgggggc ggcggatccg gggggggggg atcgggcggc      420

ggcggttcgc agtccgtgct gacccagcca cctagcgtgt cagtggcacc gggacagacc      480

gcctccattt cctgcggggg aaatgacttc ggtagccgct ccgtgtcatg gtatcaccag      540

aagccgggac aggccccggt gctggtcatc tatgacgaca acgacagacc ctcgggcatc      600

cccgaacggt tttcgggaag cacctccgga gacactgcca ccctgaccat ctcccgggtc      660

gaggtcggcg atgaagccga ttactactgc caagtctggg acgacgactc cgaccactgg      720

gtgttcggcg gcggaactaa gctgactgtg ctgggg                                756


<210>  20
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3811

<400>  20

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gln Ser Val Ala Asp Pro Gly Gly Gly Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Ala Ser Ile Ser Cys Gly Gly Asn Asp Phe Gly Ser Arg Ser Val Ser 
                165                 170                 175     


Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp 
            180                 185                 190         


Asp Asn Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Thr 
        195                 200                 205             


Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Val Gly Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asp Asp Ser Asp His Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250         


<210>  21
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3812

<400>  21
caagtgcaac tccaacaatc gggccccgga ctcgtgaaac cgtcccagac tctgtccctt       60

acttgcgtga tttccgggga ctccgtgagc tcaaactcgg cggcctggaa ctggattaga      120

cagtcccctt cccggggtct ggaatggctg ggccggactt actaccggtc gaagtggcac      180

aacgattacg cagtcagcgt cgagagccgc atcatcgtga acccggacac ctcaaagaac      240

cagttcagcc tgcaactgaa ttccgtgacc cccgaggaca ccgctgtgta ctactgcgcc      300

cgcgaccccg gatacttcta tggactggac gtctggggac aggggaccat ggtcaccgtg      360

tcgagcggcg gcggcggatc cggtggcggg ggatccggcg gtggcggatc caacttcatg      420

ttgactcagc cgcattcggt gtcggagtcc cctggaaaga cagtcaccat cccatgtacc      480

cggagcagcg gaactatcgc cgactactac gtgcagtggt accagcagcg ccctgattcc      540

tcaccgatca ttgtgatcta tgacgacaac cagaggccct ccggggtgcc ggatagattc      600

agcggatcca ttgactcctc gtccaactct gcctcactga cgatctccgg gctcaagacc      660

gaagatgaag cggcctacta ctgccagtca tacgactcca ccaaccactg ggtgtttggt      720

ggcggaacta agctgaccgt gctggga                                          747


<210>  22
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3812

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp His Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Glu Ser Arg Ile Ile Val Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Gly Tyr Phe Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Pro 
    130                 135                 140                 


His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Pro Cys Thr 
145                 150                 155                 160 


Arg Ser Ser Gly Thr Ile Ala Asp Tyr Tyr Val Gln Trp Tyr Gln Gln 
                165                 170                 175     


Arg Pro Asp Ser Ser Pro Ile Ile Val Ile Tyr Asp Asp Asn Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser 
        195                 200                 205             


Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Ala Tyr Tyr Cys Gln Ser Tyr Asp Ser Thr Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 


<210>  23
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3815

<400>  23
caagtcacac tcaaagaatc cggaccggtg ctcgtgaagc ctactgaaac cttgaccctg       60

acatgcacct tttccgggtt ctccctgagc acctcgggag tcggagtggc gtggattagg      120

cagccgccag gaaaagacct cgagtggctc gcccttatct actgggacga tgacaagcgc      180

tactcaccct cactggagag cagactgacg atcaccaagg atacctcgaa gaaccaagtg      240

gccctgacta tgtccgacat ggaccctgtg gacaccgcga cttactactg cgcccggggc      300

gattactggg gacggctgga ctactgggga cagggaactc tggtcaccgt gtccagcggc      360

ggcggtggtt cagggggtgg cggcagcggg gggggcggat cggatatcca gcttacccag      420

tcgccgtcct ccctctctgc atcgattggc gaccgcgtga ctattacgtg tcaggcctcc      480

gaggacatca acaactacct gaactggtac cagcagaagc ccggaaaggc cccaaagctg      540

ctgatctacg acgctagcaa cttggaaacc ggagtgccgt cccggttctc cggatccggg      600

agcggtaccg acttcacctt caccatcaac tccctgcaac ccgaggatat tgccacctat      660

tactgccaac agttcgacaa tatgcctctg actttcgggg gcggcactaa gctcgaaatc      720

aag                                                                    723


<210>  24
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3815

<400>  24

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Ala Leu Thr Met Ser Asp Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Tyr Trp Gly Arg Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Glu Asp Ile Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Asn Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Phe Asp Asn Met Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  25
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3815_P

<400>  25
caagtcactc tgaaagaatc cggtcccgtg ctcgtcaaac ccaccgaaac cctgaccctg       60

acctgtactt tctccggatt ttccctctca acctccggcg tgggcgtggc ctggattcgg      120

cagcctcccg gaaaggattt ggagtggctg gccctgatct actgggatga cgataagcgc      180

tactccccat ccctcgagtc ccggctgact atcactaagg acacctccaa gaatcaagtc      240

gcccttacta tgtcggacat ggaccctgtg gacaccgcta cgtactactg cgctcgggga      300

gactattggg ggcgcctgga ctactgggga cagggaaccc tcgtgaccgt gtcgtctggg      360

ggcggcggac cgggtggcgg agcgtccggg ggcggtggat cggacatcca gctgacacag      420

agccccagca gcctgagcgc ctcgattggc gacagagtga ccattacgtg ccaggcatcc      480

gaggacatca acaactacct gaactggtac cagcagaagc ctgggaaggc cccaaagctg      540

ctgatctacg acgcctccaa cctggaaacc ggagtgccgt caaggttcag cggctcggga      600

tcaggaaccg atttcacttt caccatcaac agcttgcagc cggaagatat cgcgacctac      660

tactgccaac agttcgacaa catgccgctg actttcggtg gcgggaccaa gcttgagatt      720

aag                                                                    723


<210>  26
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3815_P

<400>  26

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Ala Leu Thr Met Ser Asp Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Tyr Trp Gly Arg Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Pro Gly Gly Gly Ala 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Glu Asp Ile Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Asn Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Phe Asp Asn Met Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  27
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  27
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  28

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  29
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  29
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  30
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  30

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  31
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region of CD8.alpha

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG CL

<400>  32

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  33
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain

<400>  33
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  34
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signaling domain

<400>  34

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain

<400>  35
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  36
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta

<400>  36

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  37
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScFv CD 19

<400>  37
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  38
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv CD 19

<400>  38

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  39
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  39
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  40

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  41
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  41
ggctctgaaa gtgctgttgg aacaagaaaa gaccttcttc accttgctcg tgttgctggg       60

gtacctgtcc tgcaaagtca cctgt                                             85


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  42

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys 
            20                  25                  


<210>  43
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  43
atggcgctgc cggtgaccgc gctgctgctg ccgctggcgc tgctgctgca tgcggcgcgc       60

ccg                                                                     63


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  45
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  45
cggtcgaaga ggtccagact cttgcactcc gactacatga acatgactcc tagaaggccc       60

ggacccacta gaaagcacta ccagccgtac gcccctcctc gggatttcgc cgcataccgg      120

tcc                                                                    123


<210>  46
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  46

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  47
agagtgaagt tcagccgctc agccgatgca ccggcctacc agcagggaca gaaccagctc       60

tacaacgagc tcaacctggg tcggcgggaa gaatatgacg tgctggacaa acggcgcggc      120

agagatccgg agatgggggg aaagccgagg aggaagaacc ctcaagaggg cctgtacaac      180

gaactgcaga aggacaagat ggcggaagcc tactccgaga tcggcatgaa gggagaacgc      240

cggagaggga agggtcatga cggactgtac cagggcctgt caactgccac taaggacact      300

tacgatgcgc tccatatgca agctttgccc ccgcgg                                336


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  48

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  49
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge and transmembrane domain

<400>  49
gcggccgcgg tcggattcca agacatggaa tgcgtgccct gcggcgaccc gccacctcct       60

tacgagccgc actgcgcatc gaaggtcaac ctcgtgaaga tcgcgagcac cgcgtcctca      120

ccccgggata ctgctctggc cgccgtgatt tgttccgcct tggccaccgt gcttctggcc      180

ctgctgatcc tctgtgtgat c                                                201


<210>  50
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge and transmembrane domain

<400>  50

Ala Ala Ala Val Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp 
1               5                   10                  15      


Pro Pro Pro Pro Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val 
            20                  25                  30          


Lys Ile Ala Ser Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala 
        35                  40                  45              


Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu 
    50                  55                  60                  


Cys Val Ile 
65          


<210>  51
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  51
gccgccgtga tttgttccgc cttggccacc gtgcttctgg ccctgctgat cctctgtgtg       60

atc                                                                     63


<210>  52
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  52

Ala Ala Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ile Leu Cys Val Ile 
            20      


<210>  53
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge domain

<400>  53
gcggccgcgg tcggattcca agacatggaa tgcgtgccct gcggcgaccc gccacctcct       60

tacgagccgc actgcgcatc gaaggtcaac ctcgtgaaga tcgcgagcac cgcgtcctca      120

ccccgggata ctgctctg                                                    138


<210>  54
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge domain

<400>  54

Ala Ala Ala Val Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp 
1               5                   10                  15      


Pro Pro Pro Pro Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val 
            20                  25                  30          


Lys Ile Ala Ser Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu 
        35                  40                  45      


<210>  55
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge domain

<400>  55
tacgagcctc actgcgccag caaagtcaac ttggtgaaga tcgcgagcac tgcctcgtcc       60

cctcgggaca ctgctctggc                                                   80


<210>  56
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge domain

<400>  56

Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
1               5                   10                  15      


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu 
            20                  25      


<210>  57
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge domain fused to transmembrane domain

<400>  57
gcggccgcgc ccgcccctcg gcccccgact cctgccccga cgatcgcttc ccaacctctc       60

tcgctgcgcc cggaagcatg ccggcccgcc gccggtggcg ctgtccacac tcgcggactg      120

gactttgata ccgcactggc ggccgtgatc tgtagcgccc tggccaccgt gctgctggcg      180

ctgctcatcc tttgcgtgat ctactgcaag cggcagccta gg                         222


<210>  58
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge domain fused to transmembrane domain

<400>  58

Ala Ala Ala Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Asp Thr Ala Leu Ala Ala 
        35                  40                  45              


Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu 
    50                  55                  60                  


Cys Val Ile Tyr Cys Lys Arg Gln Pro Arg 
65                  70                  


<210>  59
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  co-stimulatory domain

<400>  59
cggtcgaaga ggtccagact cttgcactcc gactacatga acatgactcc tagaaggccc       60

ggacccacta gaaagcacta ccagccgtac gcccctcctc gggatttcgc cgcataccgg      120

tcc                                                                    123


<210>  60
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  60

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  61
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta version 2

<400>  61
cgcgtgaaat ttagccgcag cgcggatgcg ccggcgtatc agcagggcca gaaccagctg       60

tataacgaac tgaacctggg ccgccgcgaa gaatatgatg tgctggataa acgccgcggc      120

cgcgatccgg aaatgggcgg caaaccgcgc cgcaaaaacc cgcaggaagg cctgtataac      180

gaactgcaga aagataaaat ggcggaagcg tatagcgaaa ttggcatgaa aggcgaacgc      240

cgccgcggca aaggccatga tggcctgtat cagggcctga gcaccgcgac caaagatacc      300

tatgatgcgc tgcatatgca ggcgctgccg ccgcgc                                336


<210>  62
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta version 2

<400>  62

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  63
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin P2A Furin

<400>  63
cgcgcgaaac gcagcggcag cggcgcgacc aactttagcc tgctgaaaca ggcgggcgat       60

gtggaagaaa acccgggccc gcgagcaaag agg                                    93


<210>  64
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin P2A Furin

<400>  64

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg 
            20                  25                  30      


<210>  65
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin T2A

<400>  65
agagctaaac gctctgggtc tggtgaagga cgaggtagcc ttcttacgtg cggagacgtg       60

gaggaaaacc caggaccc                                                     78


<210>  66
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin T2A

<400>  66

Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      


<210>  67
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated EGFR (tEGFR) tag

<400>  67
aggaaggttt gcaatggaat cggtataggg gagtttaagg attcacttag cataaacgct       60

actaatatta aacacttcaa aaactgtacg agtataagtg gagatcttca cattttgccg      120

gttgcattcc gaggcgattc attcacccac acgccaccgc ttgacccaca agaattggat      180

attcttaaaa ccgttaaaga aataacgggg tttttgctca ttcaagcgtg gccagaaaat      240

cgcactgacc tccatgcttt cgagaacctg gagattataa gaggacgaac taagcagcat      300

ggtcaattct cccttgctgt ggtcagcctg aacatcacca gtcttggttt gcggtccctc      360

aaggaaattt cagatggaga tgtcatcata agcggcaaca agaatttgtg ctatgcaaat      420

accataaact ggaaaaaact gtttggcact tccggccaga aaaccaagat tatttcaaat      480

cggggtgaga acagctgcaa agccaccggc caggtttgtc atgccttgtg ctctccggaa      540

ggctgttggg ggccagaacc cagggactgc gtcagttgca gaaacgtctc aagaggccgc      600

gaatgcgttg acaagtgtaa cctccttgag ggtgagccac gagagtttgt tgagaacagc      660

gagtgtatac aatgtcaccc tgaatgtttg ccccaggcta tgaatataac ctgcacaggc      720

cgcgggcctg ataactgcat ccagtgtgct cattacatag atggacctca ctgtgtgaaa      780

acctgcccgg ccggagttat gggagaaaac aacactctgg tgtggaaata cgctgatgca      840

ggccacgtgt gccacctttg tcacccgaat tgtacatatg ggtgtaccgg tcctggactt      900

gaaggttgcc ctaccaatgg ccctaaaata cccagtatcg caactggcat ggtaggcgct      960

cttctcttgc tcttggtagt tgctctcggc ataggtcttt ttatg                     1005


<210>  68
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFR (tEGFR) tag

<400>  68

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  69
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3816

<400>  69
caagtgcaac tccaagaatc cggtcctggc ctcgtcaaac cttccgaaac actgtccctg       60

acctgtaccg tgtccggagg gtcgattagc tcgtcgtcat actactgggg atggatcaga      120

cagccgccgg gaaagggact cgagtggatc gggtccatct actactcggg tagcacttac      180

tacaacccgt cgctgaagtc ccgcgtgact atttccgtgg acacctccaa gaaccagttc      240

agcctgaagc tgagctccgt gaccgctgcc gataccgcag tgtactactg cgcgcgccgg      300

ggaagcatcc gcgcctttga catctgggga cagggaacta tggtcacggt gtccagcggc      360

ggtggcggat ctggcggcgg cggatccggg ggggggggaa gccagtcagt gctgactcag      420

ccgccttcgg tgtccgaggc gcccggccag agggtcacca tttcctgctc tggatcgtcc      480

agcaacattg gcaacaacgc cgtcaactgg taccagcagc tgcccgggga agcccccaag      540

ctgttgatct actacgacga gtatctgcca agcggagtgt cagacagatt ctccgcgtcg      600

aagtccggca cctccgcctc acttgcaatc tccggcctgc ggtccgagga cgaagccgat      660

tactattgcg ccgcctggga cgataatctg tccggttggg tgttcggcgg tggaacccag      720

cttaccgtgc tcgga                                                       735


<210>  70
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3816

<400>  70

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Gly Ser Ile Arg Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
    130                 135                 140                 


Ser Glu Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly 
                165                 170                 175     


Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Glu Tyr Leu Pro Ser Gly 
            180                 185                 190         


Val Ser Asp Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Trp Asp Asp Asn Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu Gly 
                245 


<210>  71
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3817

<400>  71
caagtgcaac tccaagaatc cggtcctggt ctggtcaaac cctccgaaac tctgtccctg       60

acgtgcaccg tgtcgggata ctccatttcc tccggatact actggggttg gatccgccag      120

cctccgggaa aaggcctgga atgggtcgga accatcggga aggacggatc cactttctat      180

tccccgtcgc tgaagtcacg gatcaccatt agccaggaca cctccaagaa ccagttcagc      240

ctgaagctga actccgtgaa cgccgcggac actgccgtct actactgtgc gaagcacaag      300

tggtccttcg actccgggaa cgattacttc gaccactggg gccaggggac cctcgtgacc      360

gtgtcgtccg gcggcggggg atccggtggc gggggaagcg gcggcggcgg atcagacatt      420

cagctgaccc agtctccctc atccctgtcg gctagcgtgg gcgatagagt gaccatcaca      480

tgccaggcat cgcaggacat ttcgaactat ctgaactggt accagcagaa gcctggaaag      540

gccccgaagc ttttgatcta cgacgccagc aacctggaga ctggagtgcc cagccggttc      600

agcggatcgg gatccggtac cgatttcacc tttaccatct cctcactgca accagaggat      660

atcgccacct actactgcca gcagtaccag aatctcccgc tcactttcgg acaagggact      720

aggcttgaga tcaag                                                       735


<210>  72
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M3817

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Thr Ile Gly Lys Asp Gly Ser Thr Phe Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Gln Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Asn Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Lys Trp Ser Phe Asp Ser Gly Asn Asp Tyr Phe Asp His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
            180                 185                 190         


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Gln Asn Leu Pro Leu Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys 
                245 


<210>  73
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder  M8DR H_L

<400>  73
gaggtacagt tgctggagag tggaggtggt ctggtacagc cgggagggtc cttgcggctg       60

tcatgcgcag ttagcggatt tactttcaac tccttcgcca tgtcctgggt taggcaggcc      120

cctggaaagg gtctcgaatg ggtctctgcc atcagtggga gtggaggtgg cacttactat      180

gctgacagcg tcaaagggcg cttcactatt agtcgagaca actcaaagaa tactctgtac      240

cttcaaatga actccctccg agccgaagac actgccgtat acttttgtgc taaagacaaa      300

atcctctggt tcggcgagcc tgtgttcgac tactggggac agggtacgct cgtgaccgtg      360

tcatctgcta gcggtggtgg cggctcaggt ggtggtggct ctggtggagg tggtagtgag      420

atagtactga cacagagccc ggcaactctt tctctctcac ctggtgaaag agcaaccctc      480

agttgcaggg cttcccagtc cgtatcttct tatctcgcct ggtaccaaca gaaaccgggg      540

caagcaccac gactcttgat ctatgatgcc tctaaccgcg caacagggat tccggcccga      600

tttagcggca gcggtagcgg cacggacttt acactgacga tttcttccct tgagccggaa      660

gactttgctg tgtattattg tcaacaacgg tctaattggc cgccgacgtt tggacagggc      720

acaaaggttg aaataaag                                                    738


<210>  74
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M8DR H_L

<400>  74

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  75
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M8DR L_H

<400>  75
gaaattgttt tgactcagag tcctgcgaca ttgagcttga gtccgggtga acgggctact       60

cttagttgcc gcgcctcaca gtccgtatct tcatacctcg cctggtatca acagaagccg      120

gggcaggccc ctcgcctgct tatatatgat gccagcaata gagctactgg aatacctgcc      180

cgattttctg ggtctggaag tgggacggat ttcacactga caatatcttc tcttgagccg      240

gaagactttg ccgtctatta ctgccaacag cgctctaact ggccgcccac gtttggtcag      300

ggaacaaagg tagagataaa ggggggcggt ggctccggtg ggggagggag cggaggaggt      360

ggttctgaag tccagcttct cgaatccggt gggggtctgg ttcaacctgg aggtagtctc      420

cgcttgtcct gtgctgtctc agggttcaca tttaactctt ttgctatgtc ttgggttcgg      480

caagctcctg gcaagggcct ggagtgggtg tccgctatta gtggctccgg aggcggcacg      540

tactatgcag atagtgtgaa gggcaggttt actatttccc gggataactc taagaacacc      600

ctgtacttgc agatgaatag tttgcgagcc gaagacactg cagtgtattt ttgcgccaag      660

gataaaatac tctggtttgg cgagccggta tttgactatt gggggcaagg cacacttgtc      720

acagtatcca gc                                                          732


<210>  76
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 hScFv binder M8DR L_H

<400>  76

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Val Ser Gly Phe Thr Phe Asn Ser Phe Ala Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
                165                 170                 175     


Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Lys Asp Lys Ile Leu 
    210                 215                 220                 


Trp Phe Gly Glu Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  77
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2089

<400>  77
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaattggt ccaaagcggt gcagaagtca agaaacctgg ttcgagcgtg      120

aaagtgtcct gcaaggcctc tggcggcacc ttctcatcct acgccattag ctgggtccgc      180

caagccccgg gccagggact tgagtggatg ggcggaatca tccctatctt cgggaccgcc      240

aattacgccc agaagttcca gggccgcgtg accatcaccg cggacaagtc cacatcaacc      300

gcctatatgg agctctcgtc gctgagatca gaggacactg ctgtctacta ctgtgcgagg      360

gccccatacg acgatgcatt cgacatctgg ggacagggta ccatggtcac tgtgtccagc      420

gggggcggag gctccggggg gggcggatcg gggggcggcg gatccaactt catgctgacc      480

cagccgcact cggtgtcaga gagccccgga aagactgtga ccattagctg cacccggtcc      540

agcggaagca tcgcctccaa ctacgtgcag tggtaccagc agcggccggg ctccgcgccg      600

accactgtga tctacgaaga taaccagcgc ccctccggtg tccctggacg gttctccgga      660

tccattgaca cctcgtccaa ctccgcctcg ctgacgatct ccggactgga gactgaagat      720

gaagctgtgt actactgcca atcctacgac tccggatttc cctacgccgt gttcggtggc      780

gggacccagc tcaccgtgct gggagcggcc gcaactacca cccctgcccc tcggccgccg      840

actccggccc caaccatcgc aagccaaccc ctctccttgc gccccgaagc ttgccgcccg      900

gccgcgggtg gagccgtgca tacccggggg ctggactttg cctgcgatat ctacatttgg      960

gccccgctgg ccggcacttg cggcgtgctc ctgctgtcgc tggtcatcac cctttactgc     1020

aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag     1080

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc     1140

gaactgcgcg tcaagttctc acggtccgcc gacgcccccg catatcaaca gggccagaat     1200

cagctctaca acgagctgaa cctgggaagg agagaggagt acgacgtgct ggacaagcga     1260

cgcggacgcg acccggagat gggggggaaa ccacggcgga aaaaccctca ggaaggactg     1320

tacaacgaac tccagaaaga caagatggcg gaagcctact cagaaatcgg gatgaaggga     1380

gagcggagga ggggaaaggg tcacgacggg ctgtaccagg gactgagcac cgccactaag     1440

gatacctacg atgccttgca tatgcaagca ctcccacccc gg                        1482


<210>  78
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2089

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Pro Tyr Asp Asp Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr 
145                 150                 155                 160 


Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser 
                165                 170                 175     


Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr 
            180                 185                 190         


Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn 
        195                 200                 205             


Gln Arg Pro Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Ile Asp Thr 
    210                 215                 220                 


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Glu Thr Glu Asp 
225                 230                 235                 240 


Glu Ala Val Tyr Tyr Cys Gln Ser Tyr Asp Ser Gly Phe Pro Tyr Ala 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  79
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge

<400>  79
gagagcaaat acgggccgcc atgtcccccg tgtccg                                 36


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge

<400>  80

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  81
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH2 domain

<400>  81
gcaccaccag ttgctggccc tagtgtcttc ttgttccctc ccaagcccaa agacaccttg       60

atgatttcca gaactcctga ggttacctgc gttgtcgtag atgtttctca ggaggaccca      120

gaggtccaat ttaactggta cgttgatggg gtggaagttc acaatgcgaa gacaaagccg      180

cgggaagaac aatttcagtc cacttaccgg gttgtcagcg ttctgacggt attgcatcaa      240

gactggctta atggaaagga atataagtgt aaggtgtcca acaaaggttt gccgagcagt      300

attgagaaga ccatatcaaa ggcgaag                                          327


<210>  82
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH2 domain

<400>  82

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 


<210>  83
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH3 domain

<400>  83
gggcagccgc gcgagccaca agtttacact ttgccgccat ctcaagagga aatgactaaa       60

aaccaggtat ccttgacatg cctcgtaaaa ggattttatc catctgatat tgctgtggaa      120

tgggagtcta acgggcagcc ggaaaataat tacaaaacta caccacctgt gctcgattca      180

gatggaagtt tcttccttta cagtagactt acggtggaca aatctaggtg gcaggaaggg      240

aatgtgttta gttgtagtgt aatgcacgag gcacttcata accactatac acagaagtca      300

ctgagtttga gtcttggcaa a                                                321


<210>  84
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH3 domain

<400>  84

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  85
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge CH2 CH3 domain

<400>  85
gagagcaaat acgggccgcc atgtcccccg tgtccggcac caccagttgc tggccctagt       60

gtcttcttgt tccctcccaa gcccaaagac accttgatga tttccagaac tcctgaggtt      120

acctgcgttg tcgtagatgt ttctcaggag gacccagagg tccaatttaa ctggtacgtt      180

gatggggtgg aagttcacaa tgcgaagaca aagccgcggg aagaacaatt tcagtccact      240

taccgggttg tcagcgttct gacggtattg catcaagact ggcttaatgg aaaggaatat      300

aagtgtaagg tgtccaacaa aggtttgccg agcagtattg agaagaccat atcaaaggcg      360

aaggggcagc cgcgcgagcc acaagtttac actttgccgc catctcaaga ggaaatgact      420

aaaaaccagg tatccttgac atgcctcgta aaaggatttt atccatctga tattgctgtg      480

gaatgggagt ctaacgggca gccggaaaat aattacaaaa ctacaccacc tgtgctcgat      540

tcagatggaa gtttcttcct ttacagtaga cttacggtgg acaaatctag gtggcaggaa      600

gggaatgtgt ttagttgtag tgtaatgcac gaggcacttc ataaccacta tacacagaag      660

tcactgagtt tgagtcttgg caaa                                             684


<210>  86
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 hinge CH2 CH3 domain

<400>  86

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  87
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2090

<400>  87
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaactcgt cgaatctggt ggaggatccg tgcagcctgg tggaagcctg      120

agactgtcgt gtgccgcctc cgagttcacc ttctcctcgt actggatgca ctgggtcaga      180

caggcgcccg gaaagggcct ggaatgggtg gccgtgatct catacgacgg cgcgaagaag      240

tactacgccg attccgtgaa gggccgcttt accatttccc gggacaattc aaagaacacc      300

ctctaccttc aaatgaactc cctgagggcc gaggatactg cagtctacta ctgcgctcgg      360

gatgacggga gcgggggctt cgactactgg ggacagggaa ccctcgtgac tgtgtcatcc      420

ggtggcggcg gctccggagg cggcggttcc gggggggggg gatccgacat cgtgatgacg      480

cacactcctc tgtcgctgtc cgtgaccccc ggccagcctg cctcaatctc gtgcaagagc      540

tcccagtcgc tgctgcatag cgatggaaag acctacctgt attggtacct tcaaaagccg      600

ggacagccgc cgcagttgct gatctatgaa gtcagcaacc gcttctcggg agtgcccgac      660

cgctactccg gctcggggag cggaaccgac ttcaccctga aaatttcccg ggtcgaggca      720

gaggacgtgg gagtgtacta ctgcatgcaa agcattcagt tgccactgac tttcggtgga      780

ggaaccaagc tcgaaatcaa agcggccgca actaccaccc ctgcccctcg gccgccgact      840

ccggccccaa ccatcgcaag ccaacccctc tccttgcgcc ccgaagcttg ccgcccggcc      900

gcgggtggag ccgtgcatac ccgggggctg gactttgcct gcgatatcta catttgggcc      960

ccgctggccg gcacttgcgg cgtgctcctg ctgtcgctgg tcatcaccct ttactgcaag     1020

aggggccgga agaagctgct ttacatcttc aagcagccgt tcatgcggcc cgtgcagacg     1080

actcaggaag aggacggatg ctcgtgcaga ttccctgagg aggaagaggg gggatgcgaa     1140

ctgcgcgtca agttctcacg gtccgccgac gcccccgcat atcaacaggg ccagaatcag     1200

ctctacaacg agctgaacct gggaaggaga gaggagtacg acgtgctgga caagcgacgc     1260

ggacgcgacc cggagatggg ggggaaacca cggcggaaaa accctcagga aggactgtac     1320

aacgaactcc agaaagacaa gatggcggaa gcctactcag aaatcgggat gaagggagag     1380

cggaggaggg gaaagggtca cgacgggctg taccagggac tgagcaccgc cactaaggat     1440

acctacgatg ccttgcatat gcaagcactc ccaccccgg                            1479


<210>  88
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2090

<400>  88

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Ser Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ala Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Asp Gly Ser Gly Gly Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


His Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Tyr Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser Ile Gln Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  89
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2091

<400>  89
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaattggt gcagagcggt ggaggacttg tgaaacctgg tggatccctg      120

agactttcct gtgccgcttc gggcttcacc ttctcggact actacatgtc ctggattcgc      180

caggcccctg gaaagggact ggaatgggtg tcatacatca gctcctccgg ttccaccatc      240

tactatgccg attccgtgaa gggcagattc accatctcgc gcgacaacgc caagaacact      300

ctctatctgc aaatgaactc actgcgggct gaggacaccg cggtctacta ctgcgcccgg      360

gacctcagcg gaaagtccag cggatggtcc cattacttcg attactgggg acagggaacc      420

ctggtcaccg tgtccagcgg cggggggggc tcgggtggcg gcggctccgg cggcggcggg      480

agcaacttca tgctgactca gccccactcc gtgtccgaga gcccgggaaa gaccgtgact      540

atttcgtgca cacggtcctc cgggagcatt gcgaacaact acgtgcagtg gtaccagcag      600

cggcccgata gggccccaac cactgtgatc tacgaagatg accagcggcc gtctggagtc      660

ccggaccgct tctcggggtc catcgactca tcatccaatt ccgcatcgct gacgatcagc      720

ggactgaaga tcgaggacga agccgattac tactgccagt cctacgacgg caccaactgg      780

gtctttgggg gtggaaccaa gctgactgtg ctcggagcgg ccgcaactac cacccctgcc      840

cctcggccgc cgactccggc cccaaccatc gcaagccaac ccctctcctt gcgccccgaa      900

gcttgccgcc cggccgcggg tggagccgtg catacccggg ggctggactt tgcctgcgat      960

atctacattt gggccccgct ggccggcact tgcggcgtgc tcctgctgtc gctggtcatc     1020

accctttact gcaagagggg ccggaagaag ctgctttaca tcttcaagca gccgttcatg     1080

cggcccgtgc agacgactca ggaagaggac ggatgctcgt gcagattccc tgaggaggaa     1140

gaggggggat gcgaactgcg cgtcaagttc tcacggtccg ccgacgcccc cgcatatcaa     1200

cagggccaga atcagctcta caacgagctg aacctgggaa ggagagagga gtacgacgtg     1260

ctggacaagc gacgcggacg cgacccggag atggggggga aaccacggcg gaaaaaccct     1320

caggaaggac tgtacaacga actccagaaa gacaagatgg cggaagccta ctcagaaatc     1380

gggatgaagg gagagcggag gaggggaaag ggtcacgacg ggctgtacca gggactgagc     1440

accgccacta aggataccta cgatgccttg catatgcaag cactcccacc ccgg           1494


<210>  90
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2091

<400>  90

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Ser Gly Lys Ser Ser Gly 
        115                 120                 125             


Trp Ser His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly 
                165                 170                 175     


Lys Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn 
            180                 185                 190         


Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Asp Arg Ala Pro Thr Thr 
        195                 200                 205             


Val Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser 
225                 230                 235                 240 


Gly Leu Lys Ile Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp 
                245                 250                 255     


Gly Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            260                 265                 270         


Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  91
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2092

<400>  91
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcaacttgt cgaaagcggt ggaggtcttg tccaacctgg tcgctccctg      120

aggctctcgt gtgccgcgag cggattcacc ttctcatcgt acgctatgtc ctgggtcaga      180

caggctcctg gaaagggcct ggaatgggtg gccgtgatct cctacgacgg cagcaacaag      240

tattacgccg actcagtgaa gggccggttc accatttccc gggacaacag caagaacacc      300

ctgtacttgc aaatgaactc cctgcgggcc gaggataccg cggtgtacta ctgcgcccac      360

ctccgctttg gatacggaat ggatgtctgg ggacagggaa ctaccgtgac cgtgtcgtcc      420

gggggggggg gaagcggcgg cgggggatcg ggtggcggcg gatcccagac tgtggtcacc      480

caagagcctt cactgaccgt gtccccgggt ggcaccgtga cgctgacttg cgcgtcatct      540

accggggccg tgacctcgga ccactacccc tgctggttcc agcagaaacc cggacatcca      600

ccgagagccc tggtgtactc cactgacacc atccactcct ggactccggc ccggttctcc      660

ggaagcctcc tgggcgggaa ggccgcactg acagtgtccg gagtgcagcc cgaggatgaa      720

gccgactact actgtctgct ctactatggg ggagcacgcg tgttcggtgg cggcactcag      780

ctgaccgtgc tgggagcggc cgcaactacc acccctgccc ctcggccgcc gactccggcc      840

ccaaccatcg caagccaacc cctctccttg cgccccgaag cttgccgccc ggccgcgggt      900

ggagccgtgc atacccgggg gctggacttt gcctgcgata tctacatttg ggccccgctg      960

gccggcactt gcggcgtgct cctgctgtcg ctggtcatca ccctttactg caagaggggc     1020

cggaagaagc tgctttacat cttcaagcag ccgttcatgc ggcccgtgca gacgactcag     1080

gaagaggacg gatgctcgtg cagattccct gaggaggaag aggggggatg cgaactgcgc     1140

gtcaagttct cacggtccgc cgacgccccc gcatatcaac agggccagaa tcagctctac     1200

aacgagctga acctgggaag gagagaggag tacgacgtgc tggacaagcg acgcggacgc     1260

gacccggaga tgggggggaa accacggcgg aaaaaccctc aggaaggact gtacaacgaa     1320

ctccagaaag acaagatggc ggaagcctac tcagaaatcg ggatgaaggg agagcggagg     1380

aggggaaagg gtcacgacgg gctgtaccag ggactgagca ccgccactaa ggatacctac     1440

gatgccttgc atatgcaagc actcccaccc cgg                                  1473


<210>  92
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2092 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  92

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala His Leu Arg Phe Gly Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr 
145                 150                 155                 160 


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                165                 170                 175     


Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Asp His Tyr Pro Cys Trp 
            180                 185                 190         


Phe Gln Gln Lys Pro Gly His Pro Pro Arg Ala Leu Val Tyr Ser Thr 
        195                 200                 205             


Asp Thr Ile His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
    210                 215                 220                 


Gly Gly Lys Ala Ala Leu Thr Val Ser Gly Val Gln Pro Glu Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Arg Val Phe Gly 
                245                 250                 255     


Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  93
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2093 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  93
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tgcaactcgt ccaatccgga gctgaagtca agaagccagg atcttccgtg      120

aaagtgtcgt gcaaggcctc cgggggaaca ttctcctcat atgcgatcag ctgggtccgc      180

caggctccgg gacagggctt ggagtggatg ggtatcatta acccttcggg cggctcaact      240

agctacgccc agaagttcca gggcagagtg accatgacca gggacaccag cacttcgacg      300

gtgtacatgg aactgtcctc actgcggtcc gaggacaccg ccgtgtacta ctgcgcccgg      360

gagtattcct cctcccgcgt ggacgccttc gatatctggg gacagggtac catggtcact      420

gtgtcgtccg gcggcggcgg aagcgggggt ggcgggagcg gtggcggcgg atccagctac      480

gaactcaccc agccgccgtc agtgtccgtg agcccgggac agaccgcaac cattacttgt      540

tccggggatg acctgggatc caaatacgtg tgctggtacc aacagaagcc tggtcactcg      600

cccgtgctga tcatctacga cgactcagac cggcccagcg gcatccccga gagattttcc      660

ggatccaaca gcggaaacac cgccactctg actatttcgc gcgtcgaggc cggcgacgaa      720

gcggattact actgccaagt ctgggacagc tcctcggatc atgccgtgtt cgggggcgga      780

acccagctta ccgtgctggg ggcggccgca actaccaccc ctgcccctcg gccgccgact      840

ccggccccaa ccatcgcaag ccaacccctc tccttgcgcc ccgaagcttg ccgcccggcc      900

gcgggtggag ccgtgcatac ccgggggctg gactttgcct gcgatatcta catttgggcc      960

ccgctggccg gcacttgcgg cgtgctcctg ctgtcgctgg tcatcaccct ttactgcaag     1020

aggggccgga agaagctgct ttacatcttc aagcagccgt tcatgcggcc cgtgcagacg     1080

actcaggaag aggacggatg ctcgtgcaga ttccctgagg aggaagaggg gggatgcgaa     1140

ctgcgcgtca agttctcacg gtccgccgac gcccccgcat atcaacaggg ccagaatcag     1200

ctctacaacg agctgaacct gggaaggaga gaggagtacg acgtgctgga caagcgacgc     1260

ggacgcgacc cggagatggg ggggaaacca cggcggaaaa accctcagga aggactgtac     1320

aacgaactcc agaaagacaa gatggcggaa gcctactcag aaatcgggat gaagggagag     1380

cggaggaggg gaaagggtca cgacgggctg taccagggac tgagcaccgc cactaaggat     1440

acctacgatg ccttgcatat gcaagcactc ccaccccgg                            1479


<210>  94
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2093 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  94

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Ser Ser Ser Arg Val Asp 
        115                 120                 125             


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr 
145                 150                 155                 160 


Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala 
                165                 170                 175     


Thr Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Val Cys Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly His Ser Pro Val Leu Ile Ile Tyr Asp Asp 
        195                 200                 205             


Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    210                 215                 220                 


Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Ala Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  95
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2094 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  95
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaag tgcagttggt ggagagcggt ggaggacttg tgcaacctgg tggatccctg      120

agattgtcgt gtgccgcctc cggtttcacc ttctcctcgt actggatgag ctgggtccgc      180

caggcacccg ggaagggact ggaatgggtg gcggacatta aggatgacgg ctccgagcgg      240

tactacgtgg actccgtgaa gggccggttc actatctcaa gagacaatgc caagaacagc      300

ctgtacctcc aaatgaactc gctgcgggcc gaggataccg cagtgtatta ctgcgcccgc      360

gacgtgtggg ctgggatgga tgtctggggc caggggacca ctgtcactgt gtctagcggg      420

ggcggcggaa gcggcggcgg cggatccggt ggtggcggaa gcgacattca gctgacccag      480

tccccatcat tcctgtccgc ctccgtgggc gacagggtca ctatcacttg ccaagccagc      540

caggacatct ccaactacct gaactggtac cagcagaagc ctggaaaagc tccgaagctc      600

ctcatctacg acgcctcgaa cctcgaaacc ggagtgccct cacggttttc cggatcggga      660

tcggggaccg atttctcctt caccatttca tccctgcaac ccgaggacat cgcgacctac      720

tactgccaac agacatactc cccgccgatt acgttcggac agggaacccg cctggaaatc      780

aaggcggccg caactaccac ccctgcccct cggccgccga ctccggcccc aaccatcgca      840

agccaacccc tctccttgcg ccccgaagct tgccgcccgg ccgcgggtgg agccgtgcat      900

acccgggggc tggactttgc ctgcgatatc tacatttggg ccccgctggc cggcacttgc      960

ggcgtgctcc tgctgtcgct ggtcatcacc ctttactgca agaggggccg gaagaagctg     1020

ctttacatct tcaagcagcc gttcatgcgg cccgtgcaga cgactcagga agaggacgga     1080

tgctcgtgca gattccctga ggaggaagag gggggatgcg aactgcgcgt caagttctca     1140

cggtccgccg acgcccccgc atatcaacag ggccagaatc agctctacaa cgagctgaac     1200

ctgggaagga gagaggagta cgacgtgctg gacaagcgac gcggacgcga cccggagatg     1260

ggggggaaac cacggcggaa aaaccctcag gaaggactgt acaacgaact ccagaaagac     1320

aagatggcgg aagcctactc agaaatcggg atgaagggag agcggaggag gggaaagggt     1380

cacgacgggc tgtaccaggg actgagcacc gccactaagg atacctacga tgccttgcat     1440

atgcaagcac tcccaccccg g                                               1461


<210>  96
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2094 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  96

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Asp Ile Lys Asp Asp Gly Ser Glu Arg 
65                  70                  75                  80  


Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Val Trp Ala Gly Met Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
        195                 200                 205             


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Ser Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Arg Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  97
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2095 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  97
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tccaactcgt ccagtccggt gccgaagtca agaagcctgg ctcatccgtg      120

aaagtgtcct gcaaagcatc gggcggaacc ttctcctcct atgccatttc ctgggtccgc      180

caggcaccgg gccagggtct ggagtggatg ggcgggatta tccctatctt cggaactgcc      240

aaccacgccc aaaagttcca gggacgcgtg accattaccg ccgatgaatc aacctcaacc      300

gcctacatgg aactgtccag cttgaggtcc gaggacaccg ccgtgtacta ctgcgcgttc      360

atgatggtgc cggagtacta ctttgactac tggggccagg gaacccttgt gaccgtgtcg      420

tccggtggtg gcggatccgg ggggggggga tctgggggcg gcggaagcga tatccagatg      480

acccagtcgc catcgagcct gtccgcttcc gtgggcgaca gagtgacgat cacttgccgg      540

gcttcacaag gcatcagaaa tgacctgggc tggtatcagc agaagcccgg agaagcgccc      600

aagcggctga tctacgcggc cagcaccctg caaaacggag tgccttcgcg gttctccggg      660

agcggctccg gaactgactt cactctgact attaacagcc tccagcccga ggatttcgcc      720

acatactact gtcagcagta caacagctac ccgtacacct tcggacaggg aactaagctc      780

gaaatcaagg cggccgcaac taccacccct gcccctcggc cgccgactcc ggccccaacc      840

atcgcaagcc aacccctctc cttgcgcccc gaagcttgcc gcccggccgc gggtggagcc      900

gtgcataccc gggggctgga ctttgcctgc gatatctaca tttgggcccc gctggccggc      960

acttgcggcg tgctcctgct gtcgctggtc atcacccttt actgcaagag gggccggaag     1020

aagctgcttt acatcttcaa gcagccgttc atgcggcccg tgcagacgac tcaggaagag     1080

gacggatgct cgtgcagatt ccctgaggag gaagaggggg gatgcgaact gcgcgtcaag     1140

ttctcacggt ccgccgacgc ccccgcatat caacagggcc agaatcagct ctacaacgag     1200

ctgaacctgg gaaggagaga ggagtacgac gtgctggaca agcgacgcgg acgcgacccg     1260

gagatggggg ggaaaccacg gcggaaaaac cctcaggaag gactgtacaa cgaactccag     1320

aaagacaaga tggcggaagc ctactcagaa atcgggatga agggagagcg gaggagggga     1380

aagggtcacg acgggctgta ccagggactg agcaccgcca ctaaggatac ctacgatgcc     1440

ttgcatatgc aagcactccc accccgg                                         1467


<210>  98
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2095 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  98

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn His Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Phe Met Met Val Pro Glu Tyr Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Glu Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Thr Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  99
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2096 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  99
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgaaag tgcaactcca agaaagcggc cccggacttg tcaaaccgtc ccagactctc      120

tccctgacct gtgccgtcag cggtggctca atttcgagcg gtggctacta ctggtcctgg      180

atcaggcagc atccgggaaa gggcttggag tggattggat acatctacta ctccgggtcc      240

acctactaca atccctcgct gaagtcgaga gtcaccatca gcgtggacac ctccaagaac      300

cagtttagcc tgaagctgtc ctcagtgacc gcagctgaca ccgccgtgta ctactgcgcc      360

cgcggcggag tgatgggcgg agacttcgac tactggggac agggaaccct ggtcactgtg      420

tccagcgggg gggggggatc cggcggcggc ggttccggtg gcggagggtc ccagtcagtg      480

ctgactcagc caccttccgt gtctgtgtcg cccggacaaa ccgccagcat cacgtgctcc      540

ggcgacaacc tcggtgatca ctatgtgtgc tggtaccaac agcggccggg gcagtcaccg      600

gtgctgatta tgtacgagga tactaagcgc ccttccggaa tccctgaccg gttctcggga      660

agcaactccg gaaacaccgc caccctgacc atctccggaa cccagacaat ggatgaagcg      720

gactactatt gcgtggcgtg ggacgattcg ctgtccggct gggtgttcgg cgggggaact      780

cagctgactg tgctcggagc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  100
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2096 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  100

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Lys Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Val Met Gly Gly Asp 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser 
                165                 170                 175     


Ile Thr Cys Ser Gly Asp Asn Leu Gly Asp His Tyr Val Cys Trp Tyr 
            180                 185                 190         


Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Ile Met Tyr Glu Asp Thr 
        195                 200                 205             


Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Asn Ser Gly 
    210                 215                 220                 


Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Thr Met Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Leu Ser Gly Trp Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  101
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2097 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  101
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaac tccaactcca agaatctgga ccaggcctcg tgaagccctc ccaaactctg      120

tccctgacct gtaccgtgtc gggtggaagc atttcgagcg gtggatacta ctggtcctgg      180

atcaggcagc atcctggaaa gggactggag tggattgggt acatctacta ctccggctca      240

acctactaca acccgtcctt gaaatcgcgc gtgacgatct ccgtggacac ttcaaagaac      300

cagttcagcc tgaagctttc ctccgtgacc gcggccgata cagcggtgta ctactgcgct      360

cgggatcaga gcgtggccga ccctggtggc ggctactact actacggaat ggatgtctgg      420

ggacagggaa ccaccgtgac tgtgtccagc gggggcggcg gatccggggg ggggggatcg      480

ggcggcggcg gttcgcagtc cgtgctgacc cagccaccta gcgtgtcagt ggcaccggga      540

cagaccgcct ccatttcctg cgggggaaat gacttcggta gccgctccgt gtcatggtat      600

caccagaagc cgggacaggc cccggtgctg gtcatctatg acgacaacga cagaccctcg      660

ggcatccccg aacggttttc gggaagcacc tccggagaca ctgccaccct gaccatctcc      720

cgggtcgagg tcggcgatga agccgattac tactgccaag tctgggacga cgactccgac      780

cactgggtgt tcggcggcgg aactaagctg actgtgctgg gggcggccgc aactaccacc      840

cctgcccctc ggccgccgac tccggcccca accatcgcaa gccaacccct ctccttgcgc      900

cccgaagctt gccgcccggc cgcgggtgga gccgtgcata cccgggggct ggactttgcc      960

tgcgatatct acatttgggc cccgctggcc ggcacttgcg gcgtgctcct gctgtcgctg     1020

gtcatcaccc tttactgcaa gaggggccgg aagaagctgc tttacatctt caagcagccg     1080

ttcatgcggc ccgtgcagac gactcaggaa gaggacggat gctcgtgcag attccctgag     1140

gaggaagagg ggggatgcga actgcgcgtc aagttctcac ggtccgccga cgcccccgca     1200

tatcaacagg gccagaatca gctctacaac gagctgaacc tgggaaggag agaggagtac     1260

gacgtgctgg acaagcgacg cggacgcgac ccggagatgg gggggaaacc acggcggaaa     1320

aaccctcagg aaggactgta caacgaactc cagaaagaca agatggcgga agcctactca     1380

gaaatcggga tgaagggaga gcggaggagg ggaaagggtc acgacgggct gtaccaggga     1440

ctgagcaccg ccactaagga tacctacgat gccttgcata tgcaagcact cccaccccgg     1500


<210>  102
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2097 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  102

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Ser Val Ala Asp Pro 
        115                 120                 125             


Gly Gly Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
    130                 135                 140                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
                165                 170                 175     


Val Ala Pro Gly Gln Thr Ala Ser Ile Ser Cys Gly Gly Asn Asp Phe 
            180                 185                 190         


Gly Ser Arg Ser Val Ser Trp Tyr His Gln Lys Pro Gly Gln Ala Pro 
        195                 200                 205             


Val Leu Val Ile Tyr Asp Asp Asn Asp Arg Pro Ser Gly Ile Pro Glu 
    210                 215                 220                 


Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Arg Val Glu Val Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
                245                 250                 255     


Asp Asp Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            260                 265                 270         


Leu Gly Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  103
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2098 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  103
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tgcaactcca acaatcgggc cccggactcg tgaaaccgtc ccagactctg      120

tcccttactt gcgtgatttc cggggactcc gtgagctcaa actcggcggc ctggaactgg      180

attagacagt ccccttcccg gggtctggaa tggctgggcc ggacttacta ccggtcgaag      240

tggcacaacg attacgcagt cagcgtcgag agccgcatca tcgtgaaccc ggacacctca      300

aagaaccagt tcagcctgca actgaattcc gtgacccccg aggacaccgc tgtgtactac      360

tgcgcccgcg accccggata cttctatgga ctggacgtct ggggacaggg gaccatggtc      420

accgtgtcga gcggcggcgg cggatccggt ggcgggggat ccggcggtgg cggatccaac      480

ttcatgttga ctcagccgca ttcggtgtcg gagtcccctg gaaagacagt caccatccca      540

tgtacccgga gcagcggaac tatcgccgac tactacgtgc agtggtacca gcagcgccct      600

gattcctcac cgatcattgt gatctatgac gacaaccaga ggccctccgg ggtgccggat      660

agattcagcg gatccattga ctcctcgtcc aactctgcct cactgacgat ctccgggctc      720

aagaccgaag atgaagcggc ctactactgc cagtcatacg actccaccaa ccactgggtg      780

tttggtggcg gaactaagct gaccgtgctg ggagcggccg caactaccac ccctgcccct      840

cggccgccga ctccggcccc aaccatcgca agccaacccc tctccttgcg ccccgaagct      900

tgccgcccgg ccgcgggtgg agccgtgcat acccgggggc tggactttgc ctgcgatatc      960

tacatttggg ccccgctggc cggcacttgc ggcgtgctcc tgctgtcgct ggtcatcacc     1020

ctttactgca agaggggccg gaagaagctg ctttacatct tcaagcagcc gttcatgcgg     1080

cccgtgcaga cgactcagga agaggacgga tgctcgtgca gattccctga ggaggaagag     1140

gggggatgcg aactgcgcgt caagttctca cggtccgccg acgcccccgc atatcaacag     1200

ggccagaatc agctctacaa cgagctgaac ctgggaagga gagaggagta cgacgtgctg     1260

gacaagcgac gcggacgcga cccggagatg ggggggaaac cacggcggaa aaaccctcag     1320

gaaggactgt acaacgaact ccagaaagac aagatggcgg aagcctactc agaaatcggg     1380

atgaagggag agcggaggag gggaaagggt cacgacgggc tgtaccaggg actgagcacc     1440

gccactaagg atacctacga tgccttgcat atgcaagcac tcccaccccg g              1491


<210>  104
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2098 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  104

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Val Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp His Asn Asp Tyr Ala Val Ser Val Glu Ser Arg Ile Ile Val Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Gly Tyr Phe 
        115                 120                 125             


Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn 
145                 150                 155                 160 


Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr 
                165                 170                 175     


Val Thr Ile Pro Cys Thr Arg Ser Ser Gly Thr Ile Ala Asp Tyr Tyr 
            180                 185                 190         


Val Gln Trp Tyr Gln Gln Arg Pro Asp Ser Ser Pro Ile Ile Val Ile 
        195                 200                 205             


Tyr Asp Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu 
225                 230                 235                 240 


Lys Thr Glu Asp Glu Ala Ala Tyr Tyr Cys Gln Ser Tyr Asp Ser Thr 
                245                 250                 255     


Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            260                 265                 270         


Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                325                 330                 335     


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210>  105
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2099 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  105
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tcacactcaa agaatccgga ccggtgctcg tgaagcctac tgaaaccttg      120

accctgacat gcaccttttc cgggttctcc ctgagcacct cgggagtcgg agtggcgtgg      180

attaggcagc cgccaggaaa agacctcgag tggctcgccc ttatctactg ggacgatgac      240

aagcgctact caccctcact ggagagcaga ctgacgatca ccaaggatac ctcgaagaac      300

caagtggccc tgactatgtc cgacatggac cctgtggaca ccgcgactta ctactgcgcc      360

cggggcgatt actggggacg gctggactac tggggacagg gaactctggt caccgtgtcc      420

agcggcggcg gtggttcagg gggtggcggc agcggggggg gcggatcgga tatccagctt      480

acccagtcgc cgtcctccct ctctgcatcg attggcgacc gcgtgactat tacgtgtcag      540

gcctccgagg acatcaacaa ctacctgaac tggtaccagc agaagcccgg aaaggcccca      600

aagctgctga tctacgacgc tagcaacttg gaaaccggag tgccgtcccg gttctccgga      660

tccgggagcg gtaccgactt caccttcacc atcaactccc tgcaacccga ggatattgcc      720

acctattact gccaacagtt cgacaatatg cctctgactt tcgggggcgg cactaagctc      780

gaaatcaagg cggccgcaac taccacccct gcccctcggc cgccgactcc ggccccaacc      840

atcgcaagcc aacccctctc cttgcgcccc gaagcttgcc gcccggccgc gggtggagcc      900

gtgcataccc gggggctgga ctttgcctgc gatatctaca tttgggcccc gctggccggc      960

acttgcggcg tgctcctgct gtcgctggtc atcacccttt actgcaagag gggccggaag     1020

aagctgcttt acatcttcaa gcagccgttc atgcggcccg tgcagacgac tcaggaagag     1080

gacggatgct cgtgcagatt ccctgaggag gaagaggggg gatgcgaact gcgcgtcaag     1140

ttctcacggt ccgccgacgc ccccgcatat caacagggcc agaatcagct ctacaacgag     1200

ctgaacctgg gaaggagaga ggagtacgac gtgctggaca agcgacgcgg acgcgacccg     1260

gagatggggg ggaaaccacg gcggaaaaac cctcaggaag gactgtacaa cgaactccag     1320

aaagacaaga tggcggaagc ctactcagaa atcgggatga agggagagcg gaggagggga     1380

aagggtcacg acgggctgta ccagggactg agcaccgcca ctaaggatac ctacgatgcc     1440

ttgcatatgc aagcactccc accccgg                                         1467


<210>  106
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2099 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  106

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Pro Thr Glu Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Ser Thr Ser Gly Val Gly Val Ala Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Asp Leu Glu Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Arg Tyr Ser Pro Ser Leu Glu Ser Arg Leu Thr Ile Thr Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Val Ala Leu Thr Met Ser Asp Met Asp Pro Val 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Asp Tyr Trp Gly Arg Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Gln Ala Ser Glu Asp Ile Asn Asn Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
        195                 200                 205             


Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Phe Thr Ile Asn Ser Leu Gln Pro Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Phe Asp Asn Met Pro Leu Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  107
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2501 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  107
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tcactctgaa agaatccggt cccgtgctcg tcaaacccac cgaaaccctg      120

accctgacct gtactttctc cggattttcc ctctcaacct ccggcgtggg cgtggcctgg      180

attcggcagc ctcccggaaa ggatttggag tggctggccc tgatctactg ggatgacgat      240

aagcgctact ccccatccct cgagtcccgg ctgactatca ctaaggacac ctccaagaat      300

caagtcgccc ttactatgtc ggacatggac cctgtggaca ccgctacgta ctactgcgct      360

cggggagact attgggggcg cctggactac tggggacagg gaaccctcgt gaccgtgtcg      420

tctgggggcg gcggaccggg tggcggagcg tccgggggcg gtggatcgga catccagctg      480

acacagagcc ccagcagcct gagcgcctcg attggcgaca gagtgaccat tacgtgccag      540

gcatccgagg acatcaacaa ctacctgaac tggtaccagc agaagcctgg gaaggcccca      600

aagctgctga tctacgacgc ctccaacctg gaaaccggag tgccgtcaag gttcagcggc      660

tcgggatcag gaaccgattt cactttcacc atcaacagct tgcagccgga agatatcgcg      720

acctactact gccaacagtt cgacaacatg ccgctgactt tcggtggcgg gaccaagctt      780

gagattaagg cggccgcaac taccacccct gcccctcggc cgccgactcc ggccccaacc      840

atcgcaagcc aacccctctc cttgcgcccc gaagcttgcc gcccggccgc gggtggagcc      900

gtgcataccc gggggctgga ctttgcctgc gatatctaca tttgggcccc gctggccggc      960

acttgcggcg tgctcctgct gtcgctggtc atcacccttt actgcaagag gggccggaag     1020

aagctgcttt acatcttcaa gcagccgttc atgcggcccg tgcagacgac tcaggaagag     1080

gacggatgct cgtgcagatt ccctgaggag gaagaggggg gatgcgaact gcgcgtcaag     1140

ttctcacggt ccgccgacgc ccccgcatat caacagggcc agaatcagct ctacaacgag     1200

ctgaacctgg gaaggagaga ggagtacgac gtgctggaca agcgacgcgg acgcgacccg     1260

gagatggggg ggaaaccacg gcggaaaaac cctcaggaag gactgtacaa cgaactccag     1320

aaagacaaga tggcggaagc ctactcagaa atcgggatga agggagagcg gaggagggga     1380

aagggtcacg acgggctgta ccagggactg agcaccgcca ctaaggatac ctacgatgcc     1440

ttgcatatgc aagcactccc accccgg                                         1467


<210>  108
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2501 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  108

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Pro Thr Glu Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Ser Thr Ser Gly Val Gly Val Ala Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Asp Leu Glu Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Arg Tyr Ser Pro Ser Leu Glu Ser Arg Leu Thr Ile Thr Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Val Ala Leu Thr Met Ser Asp Met Asp Pro Val 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Asp Tyr Trp Gly Arg Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Pro Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Gln Ala Ser Glu Asp Ile Asn Asn Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
        195                 200                 205             


Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Phe Thr Ile Asn Ser Leu Gln Pro Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Phe Asp Asn Met Pro Leu Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  109
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2502 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  109
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tgcaactcca agaatccggt cctggcctcg tcaaaccttc cgaaacactg      120

tccctgacct gtaccgtgtc cggagggtcg attagctcgt cgtcatacta ctggggatgg      180

atcagacagc cgccgggaaa gggactcgag tggatcgggt ccatctacta ctcgggtagc      240

acttactaca acccgtcgct gaagtcccgc gtgactattt ccgtggacac ctccaagaac      300

cagttcagcc tgaagctgag ctccgtgacc gctgccgata ccgcagtgta ctactgcgcg      360

cgccggggaa gcatccgcgc ctttgacatc tggggacagg gaactatggt cacggtgtcc      420

agcggcggtg gcggatctgg cggcggcgga tccggggggg ggggaagcca gtcagtgctg      480

actcagccgc cttcggtgtc cgaggcgccc ggccagaggg tcaccatttc ctgctctgga      540

tcgtccagca acattggcaa caacgccgtc aactggtacc agcagctgcc cggggaagcc      600

cccaagctgt tgatctacta cgacgagtat ctgccaagcg gagtgtcaga cagattctcc      660

gcgtcgaagt ccggcacctc cgcctcactt gcaatctccg gcctgcggtc cgaggacgaa      720

gccgattact attgcgccgc ctgggacgat aatctgtccg gttgggtgtt cggcggtgga      780

acccagctta ccgtgctcgg agcggccgca actaccaccc ctgcccctcg gccgccgact      840

ccggccccaa ccatcgcaag ccaacccctc tccttgcgcc ccgaagcttg ccgcccggcc      900

gcgggtggag ccgtgcatac ccgggggctg gactttgcct gcgatatcta catttgggcc      960

ccgctggccg gcacttgcgg cgtgctcctg ctgtcgctgg tcatcaccct ttactgcaag     1020

aggggccgga agaagctgct ttacatcttc aagcagccgt tcatgcggcc cgtgcagacg     1080

actcaggaag aggacggatg ctcgtgcaga ttccctgagg aggaagaggg gggatgcgaa     1140

ctgcgcgtca agttctcacg gtccgccgac gcccccgcat atcaacaggg ccagaatcag     1200

ctctacaacg agctgaacct gggaaggaga gaggagtacg acgtgctgga caagcgacgc     1260

ggacgcgacc cggagatggg ggggaaacca cggcggaaaa accctcagga aggactgtac     1320

aacgaactcc agaaagacaa gatggcggaa gcctactcag aaatcgggat gaagggagag     1380

cggaggaggg gaaagggtca cgacgggctg taccagggac tgagcaccgc cactaaggat     1440

acctacgatg ccttgcatat gcaagcactc ccaccccgg                            1479


<210>  110
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2502 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  110

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Ile Arg Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Gly Gln Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp 
            180                 185                 190         


Tyr Gln Gln Leu Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Asp 
        195                 200                 205             


Glu Tyr Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Ala Ser Lys Ser 
    210                 215                 220                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Asn Leu Ser Gly Trp Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  111
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2503 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  111
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag tgcaactcca agaatccggt cctggtctgg tcaaaccctc cgaaactctg      120

tccctgacgt gcaccgtgtc gggatactcc atttcctccg gatactactg gggttggatc      180

cgccagcctc cgggaaaagg cctggaatgg gtcggaacca tcgggaagga cggatccact      240

ttctattccc cgtcgctgaa gtcacggatc accattagcc aggacacctc caagaaccag      300

ttcagcctga agctgaactc cgtgaacgcc gcggacactg ccgtctacta ctgtgcgaag      360

cacaagtggt ccttcgactc cgggaacgat tacttcgacc actggggcca ggggaccctc      420

gtgaccgtgt cgtccggcgg cgggggatcc ggtggcgggg gaagcggcgg cggcggatca      480

gacattcagc tgacccagtc tccctcatcc ctgtcggcta gcgtgggcga tagagtgacc      540

atcacatgcc aggcatcgca ggacatttcg aactatctga actggtacca gcagaagcct      600

ggaaaggccc cgaagctttt gatctacgac gccagcaacc tggagactgg agtgcccagc      660

cggttcagcg gatcgggatc cggtaccgat ttcaccttta ccatctcctc actgcaacca      720

gaggatatcg ccacctacta ctgccagcag taccagaatc tcccgctcac tttcggacaa      780

gggactaggc ttgagatcaa ggcggccgca actaccaccc ctgcccctcg gccgccgact      840

ccggccccaa ccatcgcaag ccaacccctc tccttgcgcc ccgaagcttg ccgcccggcc      900

gcgggtggag ccgtgcatac ccgggggctg gactttgcct gcgatatcta catttgggcc      960

ccgctggccg gcacttgcgg cgtgctcctg ctgtcgctgg tcatcaccct ttactgcaag     1020

aggggccgga agaagctgct ttacatcttc aagcagccgt tcatgcggcc cgtgcagacg     1080

actcaggaag aggacggatg ctcgtgcaga ttccctgagg aggaagaggg gggatgcgaa     1140

ctgcgcgtca agttctcacg gtccgccgac gcccccgcat atcaacaggg ccagaatcag     1200

ctctacaacg agctgaacct gggaaggaga gaggagtacg acgtgctgga caagcgacgc     1260

ggacgcgacc cggagatggg ggggaaacca cggcggaaaa accctcagga aggactgtac     1320

aacgaactcc agaaagacaa gatggcggaa gcctactcag aaatcgggat gaagggagag     1380

cggaggaggg gaaagggtca cgacgggctg taccagggac tgagcaccgc cactaaggat     1440

acctacgatg ccttgcatat gcaagcactc ccaccccgg                            1479


<210>  112
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2503 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  112

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Gly Thr Ile Gly Lys Asp Gly Ser Thr 
65                  70                  75                  80  


Phe Tyr Ser Pro Ser Leu Lys Ser Arg Ile Thr Ile Ser Gln Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Asn Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys His Lys Trp Ser Phe Asp Ser Gly 
        115                 120                 125             


Asn Asp Tyr Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  113
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2525 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  113
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tacagttgct ggagagtgga ggtggtctgg tacagccggg agggtccttg      120

cggctgtcat gcgcagttag cggatttact ttcaactcct tcgccatgtc ctgggttagg      180

caggcccctg gaaagggtct cgaatgggtc tctgccatca gtgggagtgg aggtggcact      240

tactatgctg acagcgtcaa agggcgcttc actattagtc gagacaactc aaagaatact      300

ctgtaccttc aaatgaactc cctccgagcc gaagacactg ccgtatactt ttgtgctaaa      360

gacaaaatcc tctggttcgg cgagcctgtg ttcgactact ggggacaggg tacgctcgtg      420

accgtgtcat ctgctagcgg tggtggcggc tcaggtggtg gtggctctgg tggaggtggt      480

agtgagatag tactgacaca gagcccggca actctttctc tctcacctgg tgaaagagca      540

accctcagtt gcagggcttc ccagtccgta tcttcttatc tcgcctggta ccaacagaaa      600

ccggggcaag caccacgact cttgatctat gatgcctcta accgcgcaac agggattccg      660

gcccgattta gcggcagcgg tagcggcacg gactttacac tgacgatttc ttcccttgag      720

ccggaagact ttgctgtgta ttattgtcaa caacggtcta attggccgcc gacgtttgga      780

cagggcacaa aggttgaaat aaaggcggcc gcaactacca cccctgcccc tcggccgccg      840

actccggccc caaccatcgc aagccaaccc ctctccttgc gccccgaagc ttgccgcccg      900

gccgcgggtg gagccgtgca tacccggggg ctggactttg cctgcgatat ctacatttgg      960

gccccgctgg ccggcacttg cggcgtgctc ctgctgtcgc tggtcatcac cctttactgc     1020

aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag     1080

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc     1140

gaactgcgcg tcaagttctc acggtccgcc gacgcccccg catatcaaca gggccagaat     1200

cagctctaca acgagctgaa cctgggaagg agagaggagt acgacgtgct ggacaagcga     1260

cgcggacgcg acccggagat gggggggaaa ccacggcgga aaaaccctca ggaaggactg     1320

tacaacgaac tccagaaaga caagatggcg gaagcctact cagaaatcgg gatgaaggga     1380

gagcggagga ggggaaaggg tcacgacggg ctgtaccagg gactgagcac cgccactaag     1440

gatacctacg atgccttgca tatgcaagca ctcccacccc gg                        1482


<210>  114
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2525 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  114

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly 
        35                  40                  45              


Phe Thr Phe Asn Ser Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Phe Cys Ala Lys Asp Lys Ile Leu Trp Phe Gly Glu 
        115                 120                 125             


Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
                165                 170                 175     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  115
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG 2526 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  115
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggaaa ttgttttgac tcagagtcct gcgacattga gcttgagtcc gggtgaacgg      120

gctactctta gttgccgcgc ctcacagtcc gtatcttcat acctcgcctg gtatcaacag      180

aagccggggc aggcccctcg cctgcttata tatgatgcca gcaatagagc tactggaata      240

cctgcccgat tttctgggtc tggaagtggg acggatttca cactgacaat atcttctctt      300

gagccggaag actttgccgt ctattactgc caacagcgct ctaactggcc gcccacgttt      360

ggtcagggaa caaaggtaga gataaagggg ggcggtggct ccggtggggg agggagcgga      420

ggaggtggtt ctgaagtcca gcttctcgaa tccggtgggg gtctggttca acctggaggt      480

agtctccgct tgtcctgtgc tgtctcaggg ttcacattta actcttttgc tatgtcttgg      540

gttcggcaag ctcctggcaa gggcctggag tgggtgtccg ctattagtgg ctccggaggc      600

ggcacgtact atgcagatag tgtgaagggc aggtttacta tttcccggga taactctaag      660

aacaccctgt acttgcagat gaatagtttg cgagccgaag acactgcagt gtatttttgc      720

gccaaggata aaatactctg gtttggcgag ccggtatttg actattgggg gcaaggcaca      780

cttgtcacag tatccagcgc ctccgcggcc gcaactacca cccctgcccc tcggccgccg      840

actccggccc caaccatcgc aagccaaccc ctctccttgc gccccgaagc ttgccgcccg      900

gccgcgggtg gagccgtgca tacccggggg ctggactttg cctgcgatat ctacatttgg      960

gccccgctgg ccggcacttg cggcgtgctc ctgctgtcgc tggtcatcac cctttactgc     1020

aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag     1080

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc     1140

gaactgcgcg tcaagttctc acggtccgcc gacgcccccg catatcaaca gggccagaat     1200

cagctctaca acgagctgaa cctgggaagg agagaggagt acgacgtgct ggacaagcga     1260

cgcggacgcg acccggagat gggggggaaa ccacggcgga aaaaccctca ggaaggactg     1320

tacaacgaac tccagaaaga caagatggcg gaagcctact cagaaatcgg gatgaaggga     1380

gagcggagga ggggaaaggg tcacgacggg ctgtaccagg gactgagcac cgccactaag     1440

gatacctacg atgccttgca tatgcaagca ctcccacccc gg                        1482


<210>  116
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG 2526 (hScFv aCD38 CD8 TM 4-1BB CD3 zeta)

<400>  116

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asn Ser Phe 
                165                 170                 175     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Lys Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


