               SEQUENCE LISTING

<110> Glycom A/S

<120> SYNTHESIS OF A FUCOSYLATED OLIGOSACCHARIDE

<130> 134WO00

<160> 7

<150> DK201800952
<151> 2018-12-04

<170> BiSSAP 1.3.6

<210> 1
<211> 441
<212> PRT
<213> Artificial Sequence
<220> 
<223> Ma et al. J. Biol. Chem. 281, 6385 (2006)

<400> 1
Met Phe Gln Pro Leu Leu Asp Ala Tyr Val Glu Ser Ala Ser Ile Glu 
1               5                   10                  15      
Lys Met Ala Ser Lys Ser Pro Pro Pro Leu Lys Ile Ala Val Ala Asn 
            20                  25                  30          
Trp Trp Gly Asp Glu Glu Ile Lys Glu Phe Lys Asn Ser Val Leu Tyr 
        35                  40                  45              
Phe Ile Leu Ser Gln Arg Tyr Thr Ile Thr Leu His Gln Asn Pro Asn 
    50                  55                  60                  
Glu Phe Ser Asp Leu Val Phe Gly Asn Pro Leu Gly Ser Ala Arg Lys 
65                  70                  75                  80  
Ile Leu Ser Tyr Gln Asn Ala Lys Arg Val Phe Tyr Thr Gly Glu Asn 
                85                  90                  95      
Glu Ser Pro Asn Phe Asn Leu Phe Asp Tyr Ala Ile Gly Phe Asp Glu 
            100                 105                 110         
Leu Asp Phe Asn Asp Arg Tyr Leu Arg Met Pro Leu Tyr Tyr Asp Arg 
        115                 120                 125             
Leu His His Lys Ala Glu Ser Val Asn Asp Thr Thr Ala Pro Tyr Lys 
    130                 135                 140                 
Leu Lys Asp Asn Ser Leu Tyr Ala Leu Lys Lys Pro Ser His Cys Phe 
145                 150                 155                 160 
Lys Glu Lys His Pro Asn Leu Cys Ala Val Val Asn Asp Glu Ser Asp 
                165                 170                 175     
Pro Leu Lys Arg Gly Phe Ala Ser Phe Val Ala Ser Asn Pro Asn Ala 
            180                 185                 190         
Pro Ile Arg Asn Ala Phe Tyr Asp Ala Leu Asn Ser Ile Glu Pro Val 
        195                 200                 205             
Thr Gly Gly Gly Ser Val Arg Asn Thr Leu Gly Tyr Asn Val Lys Asn 
    210                 215                 220                 
Lys Asn Glu Phe Leu Ser Gln Tyr Lys Phe Asn Leu Cys Phe Glu Asn 
225                 230                 235                 240 
Thr Gln Gly Tyr Gly Tyr Val Thr Glu Lys Ile Ile Asp Ala Tyr Phe 
                245                 250                 255     
Ser His Thr Ile Pro Ile Tyr Trp Gly Ser Pro Ser Val Ala Lys Asp 
            260                 265                 270         
Phe Asn Pro Lys Ser Phe Val Asn Val His Asp Phe Lys Asn Phe Asp 
        275                 280                 285             
Glu Ala Ile Asp Tyr Ile Lys Tyr Leu His Thr His Lys Asn Ala Tyr 
    290                 295                 300                 
Leu Asp Met Leu Tyr Glu Asn Pro Leu Asn Thr Leu Asp Gly Lys Ala 
305                 310                 315                 320 
Tyr Phe Tyr Gln Asn Leu Ser Phe Lys Lys Ile Leu Ala Phe Phe Lys 
                325                 330                 335     
Thr Ile Leu Glu Asn Asp Thr Ile Tyr His Asp Asn Pro Phe Ile Phe 
            340                 345                 350         
Cys Arg Asp Leu Asn Glu Pro Leu Val Thr Ile Asp Asp Leu Arg Val 
        355                 360                 365             
Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg Ile Asn Tyr 
    370                 375                 380                 
Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg Ile Asn Tyr Asp Asp 
385                 390                 395                 400 
Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg 
                405                 410                 415     
Ile Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn 
            420                 425                 430         
Tyr Glu Arg Leu Leu Ser Lys Ala Thr

<210> 2
<211> 478
<212> PRT
<213> alpha1,3-fucosyltransferase [Helicobacter pylori NCTC 11639]


<220> 
<223> GenBank ID: AAB81031.1

<400> 2
Met Phe Gln Pro Leu Leu Asp Ala Tyr Val Glu Ser Ala Ser Ile Glu 
1               5                   10                  15      
Lys Met Ala Ser Lys Ser Pro Pro Pro Leu Lys Ile Ala Val Ala Asn 
            20                  25                  30          
Trp Trp Gly Asp Glu Glu Ile Lys Glu Phe Lys Asn Ser Val Leu Tyr 
        35                  40                  45              
Phe Ile Leu Ser Gln Arg Tyr Thr Ile Thr Leu His Gln Asn Pro Asn 
    50                  55                  60                  
Glu Phe Ser Asp Leu Val Phe Gly Asn Pro Leu Gly Ser Ala Arg Lys 
65                  70                  75                  80  
Ile Leu Ser Tyr Gln Asn Ala Lys Arg Val Phe Tyr Thr Gly Glu Asn 
                85                  90                  95      
Glu Ser Pro Asn Phe Asn Leu Phe Asp Tyr Ala Ile Gly Phe Asp Glu 
            100                 105                 110         
Leu Asp Phe Asn Asp Arg Tyr Leu Arg Met Pro Leu Tyr Tyr Asp Arg 
        115                 120                 125             
Leu His His Lys Ala Glu Ser Val Asn Asp Thr Thr Ala Pro Tyr Lys 
    130                 135                 140                 
Leu Lys Asp Asn Ser Leu Tyr Ala Leu Lys Lys Pro Ser His Cys Phe 
145                 150                 155                 160 
Lys Glu Lys His Pro Asn Leu Cys Ala Val Val Asn Asp Glu Ser Asp 
                165                 170                 175     
Pro Leu Lys Arg Gly Phe Ala Ser Phe Val Ala Ser Asn Pro Asn Ala 
            180                 185                 190         
Pro Ile Arg Asn Ala Phe Tyr Asp Ala Leu Asn Ser Ile Glu Pro Val 
        195                 200                 205             
Thr Gly Gly Gly Ser Val Arg Asn Thr Leu Gly Tyr Asn Val Lys Asn 
    210                 215                 220                 
Lys Asn Glu Phe Leu Ser Gln Tyr Lys Phe Asn Leu Cys Phe Glu Asn 
225                 230                 235                 240 
Thr Gln Gly Tyr Gly Tyr Val Thr Glu Lys Ile Ile Asp Ala Tyr Phe 
                245                 250                 255     
Ser His Thr Ile Pro Ile Tyr Trp Gly Ser Pro Ser Val Ala Lys Asp 
            260                 265                 270         
Phe Asn Pro Lys Ser Phe Val Asn Val His Asp Phe Lys Asn Phe Asp 
        275                 280                 285             
Glu Ala Ile Asp Tyr Ile Lys Tyr Leu His Thr His Lys Asn Ala Tyr 
    290                 295                 300                 
Leu Asp Met Leu Tyr Glu Asn Pro Leu Asn Thr Leu Asp Gly Lys Ala 
305                 310                 315                 320 
Tyr Phe Tyr Gln Asn Leu Ser Phe Lys Lys Ile Leu Ala Phe Phe Lys 
                325                 330                 335     
Thr Ile Leu Glu Asn Asp Thr Ile Tyr His Asp Asn Pro Phe Ile Phe 
            340                 345                 350         
Cys Arg Asp Leu Asn Glu Pro Leu Val Thr Ile Asp Asp Leu Arg Val 
        355                 360                 365             
Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg Ile Asn Tyr 
    370                 375                 380                 
Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg Ile Asn Tyr Asp Asp 
385                 390                 395                 400 
Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg 
                405                 410                 415     
Ile Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn 
            420                 425                 430         
Tyr Glu Arg Leu Leu Ser Lys Ala Thr Pro Leu Leu Glu Leu Ser Gln 
        435                 440                 445             
Asn Thr Thr Ser Lys Ile Tyr Arg Lys Ala Tyr Gln Lys Ser Leu Pro 
    450                 455                 460                 
Leu Leu Arg Ala Ile Arg Arg Trp Val Lys Lys Leu Gly Leu 
465                 470                 475             

<210> 3
<211> 425
<212> PRT
<213> fucosyltransferase [Helicobacter pylori 26695]
<220> 
<223> GenBank ID: NP_207177.1

<400> 3
Met Phe Gln Pro Leu Leu Asp Ala Phe Ile Glu Ser Ala Ser Ile Glu 
1               5                   10                  15      
Lys Met Ala Ser Lys Ser Pro Pro Pro Pro Leu Lys Ile Ala Val Ala 
            20                  25                  30          
Asn Trp Trp Gly Asp Glu Glu Ile Lys Glu Phe Lys Lys Ser Val Leu 
        35                  40                  45              
Tyr Phe Ile Leu Ser Gln Arg Tyr Ala Ile Thr Leu His Gln Asn Pro 
    50                  55                  60                  
Asn Glu Phe Ser Asp Leu Val Phe Ser Asn Pro Leu Gly Ala Ala Arg 
65                  70                  75                  80  
Lys Ile Leu Ser Tyr Gln Asn Thr Lys Arg Val Phe Tyr Thr Gly Glu 
                85                  90                  95      
Asn Glu Ser Pro Asn Phe Asn Leu Phe Asp Tyr Ala Ile Gly Phe Asp 
            100                 105                 110         
Glu Leu Asp Phe Asn Asp Arg Tyr Leu Arg Met Pro Leu Tyr Tyr Ala 
        115                 120                 125             
His Leu His Tyr Lys Ala Glu Leu Val Asn Asp Thr Thr Ala Pro Tyr 
    130                 135                 140                 
Lys Leu Lys Asp Asn Ser Leu Tyr Ala Leu Lys Lys Pro Ser His His 
145                 150                 155                 160 
Phe Lys Glu Asn His Pro Asn Leu Cys Ala Val Val Asn Asp Glu Ser 
                165                 170                 175     
Asp Leu Leu Lys Arg Gly Phe Ala Ser Phe Val Ala Ser Asn Ala Asn 
            180                 185                 190         
Ala Pro Met Arg Asn Ala Phe Tyr Asp Ala Leu Asn Ser Ile Glu Pro 
        195                 200                 205             
Val Thr Gly Gly Gly Ser Val Arg Asn Thr Leu Gly Tyr Lys Val Gly 
    210                 215                 220                 
Asn Lys Ser Glu Phe Leu Ser Gln Tyr Lys Phe Asn Leu Cys Phe Glu 
225                 230                 235                 240 
Asn Ser Gln Gly Tyr Gly Tyr Val Thr Glu Lys Ile Leu Asp Ala Tyr 
                245                 250                 255     
Phe Ser His Thr Ile Pro Ile Tyr Trp Gly Ser Pro Ser Val Ala Lys 
            260                 265                 270         
Asp Phe Asn Pro Lys Ser Phe Val Asn Val His Asp Phe Asn Asn Phe 
        275                 280                 285             
Asp Glu Ala Ile Asp Tyr Ile Lys Tyr Leu His Thr His Pro Asn Ala 
    290                 295                 300                 
Tyr Leu Asp Met Leu Tyr Glu Asn Pro Leu Asn Thr Leu Asp Gly Lys 
305                 310                 315                 320 
Ala Tyr Phe Tyr Gln Asp Leu Ser Phe Lys Lys Ile Leu Asp Phe Phe 
                325                 330                 335     
Lys Thr Ile Leu Glu Asn Asp Thr Ile Tyr His Lys Phe Ser Thr Ser 
            340                 345                 350         
Phe Met Trp Glu Tyr Asp Leu His Lys Pro Leu Val Ser Ile Asp Asp 
        355                 360                 365             
Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Arg Leu Leu 
    370                 375                 380                 
Gln Asn Ala Ser Pro Leu Leu Glu Leu Ser Gln Asn Thr Thr Phe Lys 
385                 390                 395                 400 
Ile Tyr Arg Lys Ala Tyr Gln Lys Ser Leu Pro Leu Leu Arg Ala Val 
                405                 410                 415     
Arg Lys Leu Val Lys Lys Leu Gly Leu 
            420                 425 

<210> 4
<211> 425
<212> PRT
<213> Artificial Sequence
<220> 
<223> Choi et al. Biotechnol. Bioengin. 113, 1666 (2016)

<400> 4
Met Phe Gln Pro Leu Leu Asp Ala Phe Ile Glu Ser Ala Ser Ile Glu 
1               5                   10                  15      
Lys Met Ala Ser Lys Ser Pro Pro Pro Pro Leu Lys Ile Ala Val Ala 
            20                  25                  30          
Asn Trp Trp Gly Asp Glu Glu Ile Lys Glu Phe Lys Lys Ser Val Leu 
        35                  40                  45              
Tyr Phe Ile Leu Ser Gln Arg Tyr Ala Ile Thr Leu His Gln Asn Pro 
    50                  55                  60                  
Asn Glu Phe Ser Asp Leu Val Phe Ser Asn Pro Leu Gly Ala Ala Arg 
65                  70                  75                  80  
Lys Ile Leu Ser Tyr Gln Asn Thr Lys Arg Val Phe Tyr Thr Gly Glu 
                85                  90                  95      
Asn Glu Ser Pro Asn Phe Asn Leu Phe Asp Tyr Ala Ile Gly Phe Asp 
            100                 105                 110         
Glu Leu Asp Phe Asn Asp Arg Tyr Leu Arg Met Pro Leu Tyr Tyr Asn 
        115                 120                 125             
Glu Leu His Tyr Lys Ala Glu Leu Val Asn Asp Thr Thr Ala Pro Tyr 
    130                 135                 140                 
Lys Leu Lys Asp Asn Ser Leu Tyr Ala Leu Lys Lys Pro Ser His His 
145                 150                 155                 160 
Phe Lys Glu Asn His Pro Asn Leu Cys Ala Val Val Asn Asp Glu Ser 
                165                 170                 175     
Asp Leu Leu Lys Arg Gly Phe Ala Ser Phe Val Ala Ser Asn Ala Asn 
            180                 185                 190         
Ala Pro Met Arg Asn Ala Phe Tyr Asp Ala Leu Asn Ser Ile Glu Pro 
        195                 200                 205             
Val Thr Gly Gly Gly Ser Val Arg Asn Thr Leu Gly Tyr Lys Val Gly 
    210                 215                 220                 
Asn Lys Ser Glu Phe Leu Ser Gln Tyr Lys Phe Asn Leu Cys Phe Glu 
225                 230                 235                 240 
Asn Ser Gln Gly Tyr Gly Tyr Val Thr Glu Lys Ile Leu Asp Ala Tyr 
                245                 250                 255     
Phe Ser His Thr Ile Pro Ile Tyr Trp Gly Ser Pro Ser Val Ala Lys 
            260                 265                 270         
Asp Phe Asn Pro Lys Ser Phe Val Asn Val His Asp Phe Asn Asn Phe 
        275                 280                 285             
Asp Glu Ala Ile Asp Tyr Ile Lys Tyr Leu His Thr His Pro Asn Ala 
    290                 295                 300                 
Tyr Leu Asp Met Leu Tyr Glu Asn Pro Leu Asn Thr Leu Asp Gly Lys 
305                 310                 315                 320 
Ala Tyr Phe Tyr Gln Asp Leu Ser Phe Lys Lys Ile Leu Asp Phe Phe 
                325                 330                 335     
Lys Thr Ile Leu Glu Asn Asp Thr Ile Tyr His Lys Phe Ser Thr Ser 
            340                 345                 350         
Phe Met Trp Glu Tyr Asp Leu His Lys Pro Leu Val Ser Ile Asp Asp 
        355                 360                 365             
Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Arg Leu Leu 
    370                 375                 380                 
Gln Asn Ala Ser Pro Leu Leu Glu Leu Ser Gln Asn Thr Thr Phe Lys 
385                 390                 395                 400 
Ile Tyr Arg Lys Ala Tyr Gln Lys Ser Leu Pro Leu Leu Arg Ala Val 
                405                 410                 415     
Arg Lys Leu Val Lys Lys Leu Gly Leu 
            420                 425 

<210> 5
<211> 300
<212> DNA
<213> Artificial Sequence
<220> 
<223> PglpF variant

<400> 5
gcggcacgcc ttgcagatta cggtttgcca cacttttcat ccttctcctg gtgacataat     60

ccacatcaat cgaaaatgtt aataaatttg ttgcgcgaat gatctaacaa acatgcatca    120

tgtacaatca gatggaataa atggcgcgat aacgctcatt ttatgacgag gcacacacat    180

tttaagttcg atatttctcg tttttgctcg ttaacgataa gtttacagca tgcctacaag    240

catcgtggag gtccgtgact ttcacgcata caacaaacat taaccaagga ggaaacagct    300


<210> 6
<211> 439
<212> PRT
<213> Artificial Sequence
<220> 
<223> GalTK

<400> 6
Met Ile Ser Val Tyr Ile Ile Ser Leu Lys Glu Ser Gln Arg Arg Leu 
1               5                   10                  15      
Asp Thr Glu Lys Leu Val Leu Glu Ser Asn Glu Lys Phe Lys Gly Arg 
            20                  25                  30          
Cys Val Phe Gln Ile Phe Asp Ala Ile Ser Pro Lys His Glu Asp Phe 
        35                  40                  45              
Glu Lys Phe Val Gln Glu Leu Tyr Asp Ser Ser Ser Leu Leu Lys Ser 
    50                  55                  60                  
Asp Trp Phe His Ser Asp Tyr Cys Tyr Gln Glu Leu Leu Pro Gln Glu 
65                  70                  75                  80  
Phe Gly Cys Tyr Leu Ser His Tyr Leu Leu Trp Lys Glu Cys Val Lys 
                85                  90                  95      
Leu Asn Gln Pro Val Val Ile Leu Glu Asp Asp Val Ala Leu Glu Ser 
            100                 105                 110         
Asn Phe Met Gln Ala Leu Glu Asp Cys Leu Lys Ser Pro Phe Asp Phe 
        115                 120                 125             
Val Arg Leu Tyr Gly His Tyr Trp Gly Gly His Lys Thr Asn Leu Cys 
    130                 135                 140                 
Ala Leu Pro Val Tyr Thr Glu Thr Glu Glu Ala Glu Ala Ser Ile Glu 
145                 150                 155                 160 
Lys Thr Pro Ile Glu Asn Tyr Glu Val Thr Ser Pro Pro Pro Pro Asn 
                165                 170                 175     
Pro Thr Arg Asp Thr Gln Gln Asp Phe Ile Thr Glu Thr Gln Gln Asp 
            180                 185                 190         
Pro Lys Glu Leu Ser Glu Pro Cys Lys Ile Ala Pro Gln Lys Ile Ser 
        195                 200                 205             
Phe Asn Gln Val Val Phe Lys Lys Ile Lys Arg Lys Leu Asn Arg Phe 
    210                 215                 220                 
Ile Gly Ser Ile Leu Ala Arg Thr Glu Val Tyr Lys Asn Ile Val Ala 
225                 230                 235                 240 
Lys Tyr Asp Asp Leu Thr Thr Lys Tyr Asp Asp Leu Thr Thr Lys Tyr 
                245                 250                 255     
Asp Asp Leu Thr Thr Lys Tyr Asp Asp Leu Thr Thr Lys Tyr Asp Asp 
            260                 265                 270         
Leu Asn Lys Asn Ile Ala Glu Lys Tyr Asp Glu Leu Met Gly Lys Tyr 
        275                 280                 285             
Glu Ser Leu Leu Ala Lys Glu Val Asn Ile Lys Glu Thr Phe Trp Glu 
    290                 295                 300                 
Ser Arg Ala Asp Ser Glu Lys Glu Ala Leu Phe Leu Asp His Phe Tyr 
305                 310                 315                 320 
Leu Thr Ser Val Tyr Val Ala Thr Thr Ala Gly Tyr Tyr Leu Thr Pro 
                325                 330                 335     
Lys Gly Ala Lys Thr Phe Ile Glu Ala Thr Glu Arg Phe Lys Ile Ile 
            340                 345                 350         
Glu Pro Val Asp Met Phe Ile Asn Asn Pro Thr Tyr His Asp Ile Ala 
        355                 360                 365             
Asn Phe Thr Tyr Val Pro Cys Pro Val Ser Leu Asn Lys His Ala Phe 
    370                 375                 380                 
Asn Ser Thr Ile Gln Asn Ala Lys Lys Pro Asp Ile Ser Leu Lys Pro 
385                 390                 395                 400 
Pro Lys Lys Ser Tyr Phe Asp Asn Leu Phe Tyr His Lys Phe Asn Ala 
                405                 410                 415     
Arg Lys Cys Leu Lys Ala Phe Asn Lys Tyr Ser Lys Gln Tyr Ala Pro 
            420                 425                 430         
Leu Lys Thr Pro Lys Glu Val 
        435                 


<210> 7
<211> 425
<212> PRT
<213> Artificial Sequence
<220> 
<223> 

<400> 7
Met Phe Gln Pro Leu Leu Asp Ala Phe Ile Glu Ser Ala Ser Ile Glu 
1               5                   10                  15      
Lys Met Ala Ser Lys Ser Pro Pro Pro Pro Leu Lys Ile Ala Val Ala 
            20                  25                  30          
Asn Trp Trp Gly Asp Glu Glu Ile Lys Glu Phe Lys Lys Ser Val Leu 
        35                  40                  45              
Tyr Phe Ile Leu Ser Gln Arg Tyr Ala Ile Thr Leu His Gln Asn Pro 
    50                  55                  60                  
Asn Glu Phe Ser Asp Leu Val Phe Ser Asn Pro Leu Gly Ala Ala Arg 
65                  70                  75                  80  
Lys Ile Leu Ser Tyr Gln Asn Thr Lys Arg Val Phe Tyr Thr Gly Glu 
                85                  90                  95      
Asn Glu Ser Pro Asn Phe Asn Leu Phe Asp Tyr Ala Ile Gly Phe Asp 
            100                 105                 110         
Glu Leu Asp Phe Asn Asp Arg Tyr Leu Arg Met Pro Leu Tyr Tyr Asn 
        115                 120                 125             
Glu Leu His Tyr Lys Ala Glu Leu Val Asn Asp Thr Thr Ala Pro Tyr 
    130                 135                 140                 
Lys Leu Lys Gly Asn Ser Leu Tyr Ala Leu Lys Lys Pro Ser His His 
145                 150                 155                 160 
Phe Lys Glu Asn His Pro Asn Leu Cys Ala Val Val Asn Asp Glu Ser 
                165                 170                 175     
Asp Leu Leu Lys Arg Gly Phe Ala Ser Phe Val Ala Ser Asn Ala Asn 
            180                 185                 190         
Ala Pro Met Arg Asn Ala Phe Tyr Asp Ala Leu Asn Ser Ile Glu Pro 
        195                 200                 205             
Val Thr Gly Gly Gly Ser Val Arg Asn Thr Leu Gly Cys Lys Val Gly 
    210                 215                 220                 
Asn Lys Ser Glu Phe Leu Ser Gln Tyr Lys Phe Asn Leu Cys Phe Glu 
225                 230                 235                 240 
Asn Ser Gln Gly Tyr Gly Tyr Val Thr Glu Lys Ile Leu Asp Ala Tyr 
                245                 250                 255     
Phe Ser His Thr Ile Pro Ile Tyr Trp Gly Ser Pro Ser Val Ala Lys 
            260                 265                 270         
Asp Phe Asn Pro Lys Ser Phe Val Asn Val His Asp Phe Asn Asn Phe 
        275                 280                 285             
Asp Glu Ala Ile Asp Tyr Ile Lys Tyr Leu His Thr His Pro Asn Ala 
    290                 295                 300                 
Tyr Leu Asp Met Leu Tyr Glu Asn Pro Leu Asn Thr Leu Asp Gly Lys 
305                 310                 315                 320 
Ala Tyr Phe Tyr Gln Asp Leu Ser Phe Lys Lys Ile Leu Asp Phe Phe 
                325                 330                 335     
Lys Thr Ile Leu Glu Asn Asp Thr Ile Tyr His Lys Phe Ser Thr Ser 
            340                 345                 350         
Phe Met Trp Glu Tyr Asp Leu His Lys Pro Leu Val Ser Ile Asp Asp 
        355                 360                 365             
Leu Arg Val Asn Tyr Asp Asp Leu Arg Val Asn Tyr Asp Arg Leu Leu 
    370                 375                 380                 
Gln Asn Ala Ser Pro Leu Leu Glu Leu Ser Gln Asn Thr Thr Phe Lys 
385                 390                 395                 400 
Ile Tyr Arg Lys Ala Tyr Gln Lys Ser Leu Pro Leu Leu Arg Ala Val 
                405                 410                 415     
Arg Lys Leu Val Lys Lys Leu Gly Leu 
            420                 425