                               SEQUENCE LISTING

<110> INTELLIA THERAPEUTICS, INC.
 
<120> MODIFIED AMINE LIPIDS

<130> ILH-00525

<140> PCT/US2019/064663
<141> 2019-12-05

<150> 62/775,783
<151> 2018-12-05

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
uuacagccac gucuacagca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 2
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
gacaagcacc agaaagacca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 3
<211> 4516
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
gggucccgca gucggcgucc agcggcucug cuuguucgug ugugugucgu ugcaggccuu       60

auucggaucc gccaccaugg acaagaagua cagcaucgga cuggacaucg gaacaaacag      120

cgucggaugg gcagucauca cagacgaaua caaggucccg agcaagaagu ucaagguccu      180

gggaaacaca gacagacaca gcaucaagaa gaaccugauc ggagcacugc uguucgacag      240

cggagaaaca gcagaagcaa caagacugaa gagaacagca agaagaagau acacaagaag      300

aaagaacaga aucugcuacc ugcaggaaau cuucagcaac gaaauggcaa aggucgacga      360

cagcuucuuc cacagacugg aagaaagcuu ccuggucgaa gaagacaaga agcacgaaag      420

acacccgauc uucggaaaca ucgucgacga agucgcauac cacgaaaagu acccgacaau      480

cuaccaccug agaaagaagc uggucgacag cacagacaag gcagaccuga gacugaucua      540

ccuggcacug gcacacauga ucaaguucag aggacacuuc cugaucgaag gagaccugaa      600

cccggacaac agcgacgucg acaagcuguu cauccagcug guccagacau acaaccagcu      660

guucgaagaa aacccgauca acgcaagcgg agucgacgca aaggcaaucc ugagcgcaag      720

acugagcaag agcagaagac uggaaaaccu gaucgcacag cugccgggag aaaagaagaa      780

cggacuguuc ggaaaccuga ucgcacugag ccugggacug acaccgaacu ucaagagcaa      840

cuucgaccug gcagaagacg caaagcugca gcugagcaag gacacauacg acgacgaccu      900

ggacaaccug cuggcacaga ucggagacca guacgcagac cuguuccugg cagcaaagaa      960

ccugagcgac gcaauccugc ugagcgacau ccugagaguc aacacagaaa ucacaaaggc     1020

accgcugagc gcaagcauga ucaagagaua cgacgaacac caccaggacc ugacacugcu     1080

gaaggcacug gucagacagc agcugccgga aaaguacaag gaaaucuucu ucgaccagag     1140

caagaacgga uacgcaggau acaucgacgg aggagcaagc caggaagaau ucuacaaguu     1200

caucaagccg auccuggaaa agauggacgg aacagaagaa cugcugguca agcugaacag     1260

agaagaccug cugagaaagc agagaacauu cgacaacgga agcaucccgc accagaucca     1320

ccugggagaa cugcacgcaa uccugagaag acaggaagac uucuacccgu uccugaagga     1380

caacagagaa aagaucgaaa agauccugac auucagaauc ccguacuacg ucggaccgcu     1440

ggcaagagga aacagcagau ucgcauggau gacaagaaag agcgaagaaa caaucacacc     1500

guggaacuuc gaagaagucg ucgacaaggg agcaagcgca cagagcuuca ucgaaagaau     1560

gacaaacuuc gacaagaacc ugccgaacga aaagguccug ccgaagcaca gccugcugua     1620

cgaauacuuc acagucuaca acgaacugac aaaggucaag uacgucacag aaggaaugag     1680

aaagccggca uuccugagcg gagaacagaa gaaggcaauc gucgaccugc uguucaagac     1740

aaacagaaag gucacaguca agcagcugaa ggaagacuac uucaagaaga ucgaaugcuu     1800

cgacagcguc gaaaucagcg gagucgaaga cagauucaac gcaagccugg gaacauacca     1860

cgaccugcug aagaucauca aggacaagga cuuccuggac aacgaagaaa acgaagacau     1920

ccuggaagac aucguccuga cacugacacu guucgaagac agagaaauga ucgaagaaag     1980

acugaagaca uacgcacacc uguucgacga caaggucaug aagcagcuga agagaagaag     2040

auacacagga uggggaagac ugagcagaaa gcugaucaac ggaaucagag acaagcagag     2100

cggaaagaca auccuggacu uccugaagag cgacggauuc gcaaacagaa acuucaugca     2160

gcugauccac gacgacagcc ugacauucaa ggaagacauc cagaaggcac aggucagcgg     2220

acagggagac agccugcacg aacacaucgc aaaccuggca ggaagcccgg caaucaagaa     2280

gggaauccug cagacaguca aggucgucga cgaacugguc aaggucaugg gaagacacaa     2340

gccggaaaac aucgucaucg aaauggcaag agaaaaccag acaacacaga agggacagaa     2400

gaacagcaga gaaagaauga agagaaucga agaaggaauc aaggaacugg gaagccagau     2460

ccugaaggaa cacccggucg aaaacacaca gcugcagaac gaaaagcugu accuguacua     2520

ccugcagaac ggaagagaca uguacgucga ccaggaacug gacaucaaca gacugagcga     2580

cuacgacguc gaccacaucg ucccgcagag cuuccugaag gacgacagca ucgacaacaa     2640

gguccugaca agaagcgaca agaacagagg aaagagcgac aacgucccga gcgaagaagu     2700

cgucaagaag augaagaacu acuggagaca gcugcugaac gcaaagcuga ucacacagag     2760

aaaguucgac aaccugacaa aggcagagag aggaggacug agcgaacugg acaaggcagg     2820

auucaucaag agacagcugg ucgaaacaag acagaucaca aagcacgucg cacagauccu     2880

ggacagcaga augaacacaa aguacgacga aaacgacaag cugaucagag aagucaaggu     2940

caucacacug aagagcaagc uggucagcga cuucagaaag gacuuccagu ucuacaaggu     3000

cagagaaauc aacaacuacc accacgcaca cgacgcauac cugaacgcag ucgucggaac     3060

agcacugauc aagaaguacc cgaagcugga aagcgaauuc gucuacggag acuacaaggu     3120

cuacgacguc agaaagauga ucgcaaagag cgaacaggaa aucggaaagg caacagcaaa     3180

guacuucuuc uacagcaaca ucaugaacuu cuucaagaca gaaaucacac uggcaaacgg     3240

agaaaucaga aagagaccgc ugaucgaaac aaacggagaa acaggagaaa ucgucuggga     3300

caagggaaga gacuucgcaa cagucagaaa gguccugagc augccgcagg ucaacaucgu     3360

caagaagaca gaaguccaga caggaggauu cagcaaggaa agcauccugc cgaagagaaa     3420

cagcgacaag cugaucgcaa gaaagaagga cugggacccg aagaaguacg gaggauucga     3480

cagcccgaca gucgcauaca gcguccuggu cgucgcaaag gucgaaaagg gaaagagcaa     3540

gaagcugaag agcgucaagg aacugcuggg aaucacaauc auggaaagaa gcagcuucga     3600

aaagaacccg aucgacuucc uggaagcaaa gggauacaag gaagucaaga aggaccugau     3660

caucaagcug ccgaaguaca gccuguucga acuggaaaac ggaagaaaga gaaugcuggc     3720

aagcgcagga gaacugcaga agggaaacga acuggcacug ccgagcaagu acgucaacuu     3780

ccuguaccug gcaagccacu acgaaaagcu gaagggaagc ccggaagaca acgaacagaa     3840

gcagcuguuc gucgaacagc acaagcacua ccuggacgaa aucaucgaac agaucagcga     3900

auucagcaag agagucaucc uggcagacgc aaaccuggac aagguccuga gcgcauacaa     3960

caagcacaga gacaagccga ucagagaaca ggcagaaaac aucauccacc uguucacacu     4020

gacaaaccug ggagcaccgg cagcauucaa guacuucgac acaacaaucg acagaaagag     4080

auacacaagc acaaaggaag uccuggacgc aacacugauc caccagagca ucacaggacu     4140

guacgaaaca agaaucgacc ugagccagcu gggaggagac ggaggaggaa gcccgaagaa     4200

gaagagaaag gucuagcuag ccaucacauu uaaaagcauc ucagccuacc augagaauaa     4260

gagaaagaaa augaagauca auagcuuauu caucucuuuu ucuuuuucgu ugguguaaag     4320

ccaacacccu gucuaaaaaa cauaaauuuc uuuaaucauu uugccucuuu ucucugugcu     4380

ucaauuaaua aaaaauggaa agaaccucga gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4500

aaaaaaaaaa aucuag                                                     4516


<210> 4
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 5
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 6
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210> 7
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt                            100


