                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  REDUCED AND MINIMAL MANIPULATION MANUFACTURING OF 
       GENETICALLY-MODIFIED CELLS

<130>  F053-0091PCT/19-049-WO-PCT

<150>  US 62/775,721
<151>  2018-12-05

<160>  264   

<170>  PatentIn version 3.5

<210>  1
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target locus on CCR5 gene

<400>  1
aagctcagtt tacacccgat ccactgggga gcaggaaata tct                         43


<210>  2
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homology template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Optional Alexa660N at 5' end of sequence

<400>  2
ccacttgagt ccgtgtcaca agcccacaga tatttcctgc gcggccgctc cccagtggat       60

cgggtgtaaa ctgagcttgc tcgctcgg                                          88


<210>  3
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target locus within gamma-globin gene promoter

<400>  3
tggtcaagtt tgccttgtca aggctattgg tcaaggcaag gctg                        44


<210>  4
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homology template

<400>  4
tactctaaga ctattggtca agttcgcctt gtcaaggcaa ggctggccaa cccatgggtg       60


<210>  5
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Optional Alexa488N at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Optional AltR1 at 5' end of the sequence

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Optional 18-atom hexa-ethyleneglycol spacer (iSp18) and a thiol 
       modifier C3 S-S (thioMC3-D) at the 3' end of the sequence

<400>  5
uaauuucuac ucuuguagau cacccgaucc acuggggagc a                           41


<210>  6
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cas9 crRNA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A thiol modifier C6 S-S (thioMC6-D) and an 18-atom 
       hexa-ethyleneglycol spacer (iSp18) are located at 5' end of 
       sequence

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  An optional AltR2 at the 3' end of the sequence

<400>  6
cacccgaucc acuggggagc guuuuagagc uaugcu                                 36


<210>  7
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cas9tracrRNA

<400>  7
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  8
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 HDT templatefor target strand

<400>  8
ccgagcgagc aagctcagtt tacacccgat ccactgggga gcggccgcgc aggaaatatc       60

tgtgggcttg tgacacggac tcaagtgg                                          88


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Forward primer

<400>  9
agatagtcat cttggggctg g                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Reverse primer

<400>  10
ggagtgaagg gagagtttgt c                                                 21


<210>  11
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Forward primer

<400>  11
tcgtcggcag cgtcagatgt gtataagaga cagacattgc caaacgcttc tgc              53


<210>  12
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Reverse primer

<400>  12
gtctcgtggg ctcggagatg tgtataagag acagtgcaca actctgactg ggtc             54


<210>  13
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin Cpf1 crRNA


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  An 18-atom hexa-ethyleneglycol spacer (iSp18) and a thiol 
       modifier C3 S-S (thioMC3-D) at the 3' end of the sequence

<400>  13
uaauuucuac ucuuguagau ccuugucaag gcuauugguc a                           41


<210>  14
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin Cas9 crRNA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A thiol modifier C6 S-S (thioMC6-D) and an 18-atom 
       hexa-ethyleneglycol spacer (iSp18) are located at 5' end of 
       sequence

<400>  14
cuugucaagg cuauugguca guuuuagagc uaugcu                                 36


<210>  15
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin HDT templatefor non-target strand

<400>  15
cacccatggg ttggccagcc ttgccttgac aaggcgaact tgaccaatag tcttagagta       60


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin forward primer

<400>  16
ccttcttgcc atgtgccttg                                                   20


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin reverse primer

<400>  17
tctatggtgg gagaagaaaa ctagc                                             25


<210>  18
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin forward primer

<400>  18
tcgtcggcag cgtcagatgt gtataagaga cagggcccct ggcctcact                   49


<210>  19
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin reverse primer

<400>  19
gtctcgtggg ctcggagatg tgtataagag acagtcaatg caaatatctg tctgaaacg        59


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Cpf1 crRNA


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  20
tttncacccg atccactggg gagca                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  21
tttacacccg atccactggg gagca                                             25


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Cas9 crRNA


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  22
cacccgatcc actggggagc ngg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR5 Cas9 DNA

<400>  23
cacccgatcc actggggagc agg                                               23


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globinCpf1 crRNA


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  24
tttnccttgt caaggctatt ggtca                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 Guide

<400>  25
tttgccttgt caaggctatt ggtca                                             25


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin Cas9 crRNA


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<400>  26
ccttgtcaag gctattggtc angg                                              24


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gamma-globin Cas9 DNA

<400>  27
ccttgtcagg gctgttggtc gagg                                              24


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 Guide

<400>  28
gtggggaagg ggcccccaag agg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 Guide

<400>  29
attgagatag tgtggggaag ggg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 Guide

<400>  30
cattgagata gtgtggggaa ggg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 Guide

<400>  31
gcattgagat agtgtgggga agg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 Guide

<400>  32
atttgcattg agatagtgtg ggg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  33
gtggggaagg cgcccccaag agg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  34
gtggagaagg ggcccccaag agg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  35
gtggagaagg cgcccccaag agg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  36
gtttgcattg agatagtgtg ggg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  37
gctattggtt aaggcaaggc tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  38
gctattagtc aaggcaaggc tgg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  A homology arm is located at the 3' end of the sequence

<400>  39
gctattagtt aaggcaaggc tgg                                               23


<210>  40
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  A homology arm is located at the 3' end of the sequence

<400>  40
gtttgccttg                                                              10


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  A homology arm is located at the 3' end of the sequence

<400>  41
tttgccttag ttaaggcaag gctgg                                             25


<210>  42
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 Guide

<400>  42
tttgcattga gatagtgtgg ggaag                                             25


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 Guide

<400>  43
tttagccagg gaccgtttca gacag                                             25


<210>  44
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  A homology arm is located at the 3' end of the sequence

<400>  44
tttgcattga gatagtgtgg ggaaggcgcc ccc                                    33


<210>  45
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  A homology arm is located at the 3' end of the sequence

<400>  45
tttgcattga gatagtgtgg agaaggggcc ccc                                    33


<210>  46
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  A homology arm is located at the 3' end of the sequence

<400>  46
tttgcattga gatagtgtgg agaaggcgcc ccc                                    33


<210>  47
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  A homology arm is located at the 3' end of the sequence

<400>  47
tttagccagg gaccgtttca gacagatgtt tgca                                   34


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  A homology arm is located at the 3' end of the sequence

<400>  48
tttgccttgt caaggctatt ggtta                                             25


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  A homology arm is located at the 3' end of the sequence

<400>  49
tttgccttgt caaggctatt agtca                                             25


<210>  50
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  A homology arm is located at the 3' end of the sequence

<400>  50
tttgccttgt caaggctatt agtta                                             25


<210>  51
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  A homology arm is located at the 3' end of the sequence

<400>  51
tttgccttgt ca                                                           12


<210>  52
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 HDR Template


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  A homology arm is located at the 5' end of the sequence

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  A homology arm is located at the 3' end of the sequence

<400>  52
tttgccttag tta                                                          13


<210>  53
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro 
1               5                   10                  15      


Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
            20                  25                  30          


Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val 
        35                  40                  45              


Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr 
    50                  55                  60                  


Val Met Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser 
65                  70                  75                  80  


Thr Cys Tyr Tyr His Lys Ser 
                85          


<210>  54
<211>  87
<212>  PRT
<213>  Mus musculus

<400>  54

Gly Cys Pro Glu Cys Lys Leu Lys Glu Asn Lys Tyr Phe Ser Lys Leu 
1               5                   10                  15      


Gly Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
            20                  25                  30          


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
        35                  40                  45              


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
    50                  55                  60                  


Val Met Gly Asn Ala Arg Val Glu Asn His Thr Glu Cys His Cys Ser 
65                  70                  75                  80  


Thr Cys Tyr Tyr His Lys Ser 
                85          


<210>  55
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Arg Glu Pro Leu Arg Pro Trp Cys His Pro Ile Asn Ala Ile Leu 
1               5                   10                  15      


Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr 
            20                  25                  30          


Ile Cys Ala Gly Tyr Cys Pro Thr Met Met Arg Val Leu Gln Ala Val 
        35                  40                  45              


Leu Pro Pro Leu Pro Gln Val Val Cys Thr Tyr Arg Asp Val Arg Phe 
    50                  55                  60                  


Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asp Pro Val Val 
65                  70                  75                  80  


Ser Phe Pro Val Ala Leu Ser Cys Arg Cys Gly Pro Cys Arg Arg Ser 
                85                  90                  95      


Thr Ser Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp His 
            100                 105                 110         


Pro Gln Leu Ser Gly Leu Leu Phe Leu 
        115                 120     


<210>  56
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  56

Ser Arg Gly Pro Leu Arg Pro Leu Cys Arg Pro Val Asn Ala Thr Leu 
1               5                   10                  15      


Ala Ala Glu Asn Glu Phe Cys Pro Val Cys Ile Thr Phe Thr Thr Ser 
            20                  25                  30          


Ile Cys Ala Gly Tyr Cys Pro Ser Met Val Arg Val Leu Pro Ala Ala 
        35                  40                  45              


Leu Pro Pro Val Pro Gln Pro Val Cys Thr Tyr Arg Glu Leu Arg Phe 
    50                  55                  60                  


Ala Ser Val Arg Leu Pro Gly Cys Pro Pro Gly Val Asp Pro Ile Val 
65                  70                  75                  80  


Ser Phe Pro Val Ala Leu Ser Cys Arg Cys Gly Pro Cys Arg Leu Ser 
                85                  90                  95      


Ser Ser Asp Cys Gly Gly Pro Arg Thr Gln Pro Met Ala Cys Asp Leu 
            100                 105                 110         


Pro His Leu Pro Gly Leu Leu Leu Leu 
        115                 120     


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 anti-LHR binding agent

<400>  57

Gly Tyr Ser Ile Thr Ser Gly Tyr Gly 
1               5                   


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 anti-LHR binding agent

<400>  58

Ile His Tyr Ser Gly Ser Thr 
1               5           


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 anti-LHR binding agent

<400>  59

Ala Arg Ser Leu Arg Tyr 
1               5       


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 anti-LHR binding agent

<400>  60

Ser Ser Val Asn Tyr 
1               5   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 anti-LHR binding agent

<400>  61

His Gln Trp Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 anti-LHR binding agent

<400>  62

Gly Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 anti-LHR binding agent

<400>  63

Ile Trp Gly Asp Gly Ser Thr 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 anti-LHR binding agent

<400>  64

Ala Glu Gly Ser Ser Leu Phe Ala Tyr 
1               5                   


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 anti-LHR binding agent

<400>  65

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 anti-LHR binding agent

<400>  66

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 anti-LHR binding agent

<400>  67

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 anti-LHR binding agent

<400>  68

Ile Tyr Pro Tyr Asn Gly Val Ser 
1               5               


<210>  69
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 anti-LHR binding agent

<400>  69

Ala Arg Glu Arg Gly Leu Tyr Gln Leu Arg Ala Met Asp Tyr 
1               5                   10                  


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 anti-LHR binding agent

<400>  70

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 anti-LHR binding agent

<400>  71

Gln Gln Ser Asn Ser Trp Pro Tyr Thr 
1               5                   


<210>  72
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent heavy chain

<400>  72

Glu Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile His Tyr Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys Ser 
    50                  55                  60                  


Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln 
65                  70                  75                  80  


Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ser Leu Arg Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110     


<210>  73
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent light chain

<400>  73

Asp Ile Val Met Thr Gln Thr Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Leu Gly Ser Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  74
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent heavy chain

<400>  74

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Arg Arg Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Tyr Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Glu Gly Ser Ser Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  75
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent light chain


<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Xaa Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  76
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent heavy chain

<400>  76

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Lys Leu Pro Ser Leu Cys Tyr Gly Leu Leu Gly Ser Arg 
                85                  90                  95      


Asn Leu Ser His Arg Leu Leu 
            100             


<210>  77
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent light chain

<400>  77

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Phe Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu Leu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  78
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent heavy chain

<400>  78

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Asn Ile Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Val Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Leu Tyr Gln Leu Arg Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  79
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LHR binding agent light chain

<400>  79

Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Asn Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  80
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  80
uaauuucuac ucuuguagau uucggacccg ugcuacaacu u                           41


<210>  81
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  81
uaauuucuac ucuuguagau auagaauagc cucauauuuu a                           41


<210>  82
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  82
uaauuucuac ucuuguagau gagcuguugg caucauguuc cug                         43


<210>  83
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  83
uaauuucuac ucuuguagau uccaaaccuc cuaaaugaua c                           41


<210>  84
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  84
tttgtgtccc cgttttggtt ggtaaac                                           27


<210>  85
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  85
tttaaaaatc aataccgata ataatga                                           27


<210>  86
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  86
tttcttaata tgaatattaa tatcggt                                           27


<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  87
tttccgtatc tggaaggggc atcttgg                                           27


<210>  88
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  88
tttccttagg accggaagga ttacagc                                           27


<210>  89
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  89
tttgcctaaa aggcactatg tcaaatg                                           27


<210>  90
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  90
tttggagctg ttggcatcat gttcctg                                           27


<210>  91
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  91
tttgattctt ttctatctca ggacaga                                           27


<210>  92
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  92
tttatagaca tcccacactg tagttct                                           27


<210>  93
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  93
tttattaatt tgagaaccaa cataagg                                           27


<210>  94
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  94
tttattttct ttttggtaag aaggaac                                           27


<210>  95
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  95
tttcacacac acacacacac acacaca                                           27


<210>  96
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  96
tttatccaaa cctcctaaat gatac                                             25


<210>  97
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target site


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  PAM site

<400>  97
tttttgattc ttttctatct caggaca                                           27


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly Ser linker

<400>  98

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly Ser linker

<400>  99

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly Ser linker

<400>  100

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser 
1               5                   10      


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH2

<400>  101

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
1               5                   10                  


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH3

<400>  102

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD8 CDRL1

<400>  103

Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala 
1               5                   10      


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD8 CDRL2

<400>  104

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD8 CDRL3

<400>  105

Gln Gln His Asn Glu Asn Pro Leu Thr 
1               5                   


<210>  106
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD8 CDRH1

<400>  106

Gly Phe Asn Ile Lys Asp 
1               5       


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD8 CDRH2

<400>  107

Arg Ile Asp Pro Ala Asn Asp Asn Thr 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD8 CDRH3

<400>  108

Gly Tyr Gly Tyr Tyr Val Phe Asp His 
1               5                   


<210>  109
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-KIR2DL1 and anti-KIR2DL2/3 variable light chain

<400>  109

Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  110
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-KIR2DL1 and anti-KIR2DL2/3 variable heavy chain

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  111
<211>  35
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  111
gcucaaccca cccuccuaca uagggaggaa cgagu                                  35


<210>  112
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes

<400>  112
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  113
<211>  3903
<212>  DNA
<213>  Francisella tularensis

<400>  113
atgtcaattt atcaagaatt tgttaataaa tatagtttaa gtaaaactct aagatttgag       60

ttaatcccac agggtaaaac acttgaaaac ataaaagcaa gaggtttgat tttagatgat      120

gagaaaagag ctaaagacta caaaaaggct aaacaaataa ttgataaata tcatcagttt      180

tttatagagg agatattaag ttcggtttgt attagcgaag atttattaca aaactattct      240

gatgtttatt ttaaacttaa aaagagtgat gatgataatc tacaaaaaga ttttaaaagt      300

gcaaaagata cgataaagaa acaaatatct gaatatataa aggactcaga gaaatttaag      360

aatttgttta atcaaaacct tatcgatgct aaaaaagggc aagagtcaga tttaattcta      420

tggctaaagc aatctaagga taatggtata gaactattta aagccaatag tgatatcaca      480

gatatagatg aggcgttaga aataatcaaa tcttttaaag gttggacaac ttattttaag      540

ggttttcatg aaaatagaaa aaatgtttat agtagcaatg atattcctac atctattatt      600

tataggatag tagatgataa tttgcctaaa tttctagaaa ataaagctaa gtatgagagt      660

ttaaaagaca aagctccaga agctataaac tatgaacaaa ttaaaaaaga tttggcagaa      720

gagctaacct ttgatattga ctacaaaaca tctgaagtta atcaaagagt tttttcactt      780

gatgaagttt ttgagatagc aaactttaat aattatctaa atcaaagtgg tattactaaa      840

tttaatacta ttattggtgg taaatttgta aatggtgaaa atacaaagag aaaaggtata      900

aatgaatata taaatctata ctcacagcaa ataaatgata aaacactcaa aaaatataaa      960

atgagtgttt tatttaagca aattttaagt gatacagaat ctaaatcttt tgtaattgat     1020

aagttagaag atgatagtga tgtagttaca acgatgcaaa gtttttatga gcaaatagca     1080

gcttttaaaa cagtagaaga aaaatctatt aaagaaacac tatctttatt atttgatgat     1140

ttaaaagctc aaaaacttga tttgagtaaa atttatttta aaaatgataa atctcttact     1200

gatctatcac aacaagtttt tgatgattat agtgttattg gtacagcggt actagaatat     1260

ataactcaac aaatagcacc taaaaatctt gataacccta gtaagaaaga gcaagaatta     1320

atagccaaaa aaactgaaaa agcaaaatac ttatctctag aaactataaa gcttgcctta     1380

gaagaattta ataagcatag agatatagat aaacagtgta ggtttgaaga aatacttgca     1440

aactttgcgg ctattccgat gatatttgat gaaatagctc aaaacaaaga caatttggca     1500

cagatatcta tcaaatatca aaatcaaggt aaaaaagacc tacttcaagc tagtgcggaa     1560

gatgatgtta aagctatcaa ggatctttta gatcaaacta ataatctctt acataaacta     1620

aaaatatttc atattagtca gtcagaagat aaggcaaata ttttagacaa ggatgagcat     1680

ttttatctag tatttgagga gtgctacttt gagctagcga atatagtgcc tctttataac     1740

aaaattagaa actatataac tcaaaagcca tatagtgatg agaaatttaa gctcaatttt     1800

gagaactcga ctttggctaa tggttgggat aaaaataaag agcctgacaa tacggcaatt     1860

ttatttatca aagatgataa atattatctg ggtgtgatga ataagaaaaa taacaaaata     1920

tttgatgata aagctatcaa agaaaataaa ggcgagggtt ataaaaaaat tgtttataaa     1980

cttttacctg gcgcaaataa aatgttacct aaggttttct tttctgctaa atctataaaa     2040

ttttataatc ctagtgaaga tatacttaga ataagaaatc attccacaca tacaaaaaat     2100

ggtagtcctc aaaaaggata tgaaaaattt gagtttaata ttgaagattg ccgaaaattt     2160

atagattttt ataaacagtc tataagtaag catccggagt ggaaagattt tggatttaga     2220

ttttctgata ctcaaagata taattctata gatgaatttt atagagaagt tgaaaatcaa     2280

ggctacaaac taacttttga aaatatatca gagagctata ttgatagcgt agttaatcag     2340

ggtaaattgt acctattcca aatctataat aaagattttt cagcttatag caaagggcga     2400

ccaaatctac atactttata ttggaaagcg ctgtttgatg agagaaatct tcaagatgtg     2460

gtttataagc taaatggtga ggcagagctt ttttatcgta aacaatcaat acctaaaaaa     2520

atcactcacc cagctaaaga ggcaatagct aataaaaaca aagataatcc taaaaaagag     2580

agtgtttttg aatatgattt aatcaaagat aaacgcttta ctgaagataa gtttttcttt     2640

cactgtccta ttacaatcaa ttttaaatct agtggagcta ataagtttaa tgatgaaatc     2700

aatttattgc taaaagaaaa agcaaatgat gttcatatat taagtataga tagaggtgaa     2760

agacatttag cttactatac tttggtagat ggtaaaggca atatcatcaa acaagatact     2820

ttcaacatca ttggtaatga tagaatgaaa acaaactacc atgataagct tgctgcaata     2880

gagaaagata gggattcagc taggaaagac tggaaaaaga taaataacat caaagagatg     2940

aaagagggct atctatctca ggtagttcat gaaatagcta agctagttat agagtataat     3000

gctattgtgg tttttgagga tttaaatttt ggatttaaaa gagggcgttt caaggtagag     3060

aagcaggtct atcaaaagtt agaaaaaatg ctaattgaga aactaaacta tctagttttc     3120

aaagataatg agtttgataa aactggggga gtgcttagag cttatcagct aacagcacct     3180

tttgagactt ttaaaaagat gggtaaacaa acaggtatta tctactatgt accagctggt     3240

tttacttcaa aaatttgtcc tgtaactggt tttgtaaatc agttatatcc taagtatgaa     3300

agtgtcagca aatctcaaga gttctttagt aagtttgaca agatttgtta taaccttgat     3360

aagggctatt ttgagtttag ttttgattat aaaaactttg gtgacaaggc tgccaaaggc     3420

aagtggacta tagctagctt tgggagtaga ttgattaact ttagaaattc agataaaaat     3480

cataattggg atactcgaga agtttatcca actaaagagt tggagaaatt gctaaaagat     3540

tattctatcg aatatgggca tggcgaatgt atcaaagcag ctatttgcgg tgagagcgac     3600

aaaaagtttt ttgctaagct aactagtgtc ctaaatacta tcttacaaat gcgtaactca     3660

aaaacaggta ctgagttaga ttatctaatt tcaccagtag cagatgtaaa tggcaatttc     3720

tttgattcgc gacaggcgcc aaaaaatatg cctcaagatg ctgatgccaa tggtgcttat     3780

catattgggc taaaaggtct gatgctacta ggtaggatca aaaataatca agagggcaaa     3840

aaactcaatt tggttatcaa aaatgaagag tattttgagt tcgtgcagaa taggaataac     3900

taa                                                                   3903


<210>  114
<211>  3921
<212>  DNA
<213>  Acidaminococcus sp. BV3L6

<400>  114
atgacacagt tcgagggctt taccaacctg tatcaggtga gcaagacact gcggtttgag       60

ctgatcccac agggcaagac cctgaagcac atccaggagc agggcttcat cgaggaggac      120

aaggcccgca atgatcacta caaggagctg aagcccatca tcgatcggat ctacaagacc      180

tatgccgacc agtgcctgca gctggtgcag ctggattggg agaacctgag cgccgccatc      240

gactcctata gaaaggagaa aaccgaggag acaaggaacg ccctgatcga ggagcaggcc      300

acatatcgca atgccatcca cgactacttc atcggccgga cagacaacct gaccgatgcc      360

atcaataaga gacacgccga gatctacaag ggcctgttca aggccgagct gtttaatggc      420

aaggtgctga agcagctggg caccgtgacc acaaccgagc acgagaacgc cctgctgcgg      480

agcttcgaca agtttacaac ctacttctcc ggcttttatg agaacaggaa gaacgtgttc      540

agcgccgagg atatcagcac agccatccca caccgcatcg tgcaggacaa cttccccaag      600

tttaaggaga attgtcacat cttcacacgc ctgatcaccg ccgtgcccag cctgcgggag      660

cactttgaga acgtgaagaa ggccatcggc atcttcgtga gcacctccat cgaggaggtg      720

ttttccttcc ctttttataa ccagctgctg acacagaccc agatcgacct gtataaccag      780

ctgctgggag gaatctctcg ggaggcaggc accgagaaga tcaagggcct gaacgaggtg      840

ctgaatctgg ccatccagaa gaatgatgag acagcccaca tcatcgcctc cctgccacac      900

agattcatcc ccctgtttaa gcagatcctg tccgatagga acaccctgtc tttcatcctg      960

gaggagttta agagcgacga ggaagtgatc cagtccttct gcaagtacaa gacactgctg     1020

agaaacgaga acgtgctgga gacagccgag gccctgttta acgagctgaa cagcatcgac     1080

ctgacacaca tcttcatcag ccacaagaag ctggagacaa tcagcagcgc cctgtgcgac     1140

cactgggata cactgaggaa tgccctgtat gagcggagaa tctccgagct gacaggcaag     1200

atcaccaagt ctgccaagga gaaggtgcag cgcagcctga agcacgagga tatcaacctg     1260

caggagatca tctctgccgc aggcaaggag ctgagcgagg ccttcaagca gaaaaccagc     1320

gagatcctgt cccacgcaca cgccgccctg gatcagccac tgcctacaac cctgaagaag     1380

caggaggaga aggagatcct gaagtctcag ctggacagcc tgctgggcct gtaccacctg     1440

ctggactggt ttgccgtgga tgagtccaac gaggtggacc ccgagttctc tgcccggctg     1500

accggcatca agctggagat ggagccttct ctgagcttct acaacaaggc cagaaattat     1560

gccaccaaga agccctactc cgtggagaag ttcaagctga actttcagat gcctacactg     1620

gcctctggct gggacgtgaa taaggagaag aacaatggcg ccatcctgtt tgtgaagaac     1680

ggcctgtact atctgggcat catgccaaag cagaagggca ggtataaggc cctgagcttc     1740

gagcccacag agaaaaccag cgagggcttt gataagatgt actatgacta cttccctgat     1800

gccgccaaga tgatcccaaa gtgcagcacc cagctgaagg ccgtgacagc ccactttcag     1860

acccacacaa cccccatcct gctgtccaac aatttcatcg agcctctgga gatcacaaag     1920

gagatctacg acctgaacaa tcctgagaag gagccaaaga agtttcagac agcctacgcc     1980

aagaaaaccg gcgaccagaa gggctacaga gaggccctgt gcaagtggat cgacttcaca     2040

agggattttc tgtccaagta taccaagaca acctctatcg atctgtctag cctgcggcca     2100

tcctctcagt ataaggacct gggcgagtac tatgccgagc tgaatcccct gctgtaccac     2160

atcagcttcc agagaatcgc cgagaaggag atcatggatg ccgtggagac aggcaagctg     2220

tacctgttcc agatctataa caaggacttt gccaagggcc accacggcaa gcctaatctg     2280

cacacactgt attggaccgg cctgttttct ccagagaacc tggccaagac aagcatcaag     2340

ctgaatggcc aggccgagct gttctaccgc cctaagtcca ggatgaagag gatggcacac     2400

cggctgggag agaagatgct gaacaagaag ctgaaggatc agaaaacccc aatccccgac     2460

accctgtacc aggagctgta cgactatgtg aatcacagac tgtcccacga cctgtctgat     2520

gaggccaggg ccctgctgcc caacgtgatc accaaggagg tgtctcacga gatcatcaag     2580

gataggcgct ttaccagcga caagttcttt ttccacgtgc ctatcacact gaactatcag     2640

gccgccaatt ccccatctaa gttcaaccag agggtgaatg cctacctgaa ggagcacccc     2700

gagacaccta tcatcggcat cgatcggggc gagagaaacc tgatctatat cacagtgatc     2760

gactccaccg gcaagatcct ggagcagcgg agcctgaaca ccatccagca gtttgattac     2820

cagaagaagc tggacaacag ggagaaggag agggtggcag caaggcaggc ctggtctgtg     2880

gtgggcacaa tcaaggatct gaagcagggc tatctgagcc aggtcatcca cgagatcgtg     2940

gacctgatga tccactacca ggccgtggtg gtgctggaga acctgaattt cggctttaag     3000

agcaagagga ccggcatcgc cgagaaggcc gtgtaccagc agttcgagaa gatgctgatc     3060

gataagctga attgcctggt gctgaaggac tatccagcag agaaagtggg aggcgtgctg     3120

aacccatacc agctgacaga ccagttcacc tcctttgcca agatgggcac ccagtctggc     3180

ttcctgtttt acgtgcctgc cccatataca tctaagatcg atcccctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaat cacgagagcc gcaagcactt cctggagggc     3300

ttcgactttc tgcactacga cgtgaaaacc ggcgacttca tcctgcactt taagatgaac     3360

agaaatctgt ccttccagag gggcctgccc ggctttatgc ctgcatggga tatcgtgttc     3420

gagaagaacg agacacagtt tgacgccaag ggcacccctt tcatcgccgg caagagaatc     3480

gtgccagtga tcgagaatca cagattcacc ggcagatacc gggacctgta tcctgccaac     3540

gagctgatcg ccctgctgga ggagaagggc atcgtgttca gggatggctc caacatcctg     3600

ccaaagctgc tggagaatga cgattctcac gccatcgaca ccatggtggc cctgatccgc     3660

agcgtgctgc agatgcggaa ctccaatgcc gccacaggcg aggactatat caacagcccc     3720

gtgcgcgatc tgaatggcgt gtgcttcgac tcccggtttc agaacccaga gtggcccatg     3780

gacgccgatg ccaatggcgc ctaccacatc gccctgaagg gccagctgct gctgaatcac     3840

ctgaaggaga gcaaggatct gaagctgcag aacggcatct ccaatcagga ctggctggcc     3900

tacatccagg agctgcgcaa c                                               3921


<210>  115
<211>  3699
<212>  DNA
<213>  Lachnospiraceae bacterium

<400>  115
atggattacg gcaacggcca gtttgagcgg agagcccccc tgaccaagac aatcaccctg       60

cgcctgaagc ctatcggcga gacacgggag acaatccgcg agcagaagct gctggagcag      120

gacgccgcct tcagaaagct ggtggagaca gtgaccccta tcgtggacga ttgtatcagg      180

aagatcgccg ataacgccct gtgccacttt ggcaccgagt atgacttcag ctgtctgggc      240

aacgccatct ctaagaatga cagcaaggcc atcaagaagg agacagagaa ggtggagaag      300

ctgctggcca aggtgctgac cgagaatctg ccagatggcc tgcgcaaggt gaacgacatc      360

aattccgccg cctttatcca ggatacactg acctctttcg tgcaggacga tgccgacaag      420

cgggtgctga tccaggagct gaagggcaag accgtgctga tgcagcggtt cctgaccaca      480

cggatcacag ccctgaccgt gtggctgccc gacagagtgt tcgagaactt taatatcttc      540

atcgagaacg ccgagaagat gagaatcctg ctggactccc ctctgaatga gaagatcatg      600

aagtttgacc cagatgccga gcagtacgcc tctctggagt tctatggcca gtgcctgtct      660

cagaaggaca tcgatagcta caacctgatc atctccggca tctatgccga cgatgaggtg      720

aagaaccctg gcatcaatga gatcgtgaag gagtacaatc agcagatccg gggcgacaag      780

gatgagtccc cactgcccaa gctgaagaag ctgcacaagc agatcctgat gccagtggag      840

aaggccttct ttgtgcgcgt gctgtctaac gacagcgatg cccggagcat cctggagaag      900

atcctgaagg acacagagat gctgccctcc aagatcatcg aggccatgaa ggaggcagat      960

gcaggcgaca tcgccgtgta cggcagccgg ctgcacgagc tgagccacgt gatctacggc     1020

gatcacggca agctgtccca gatcatctat gacaaggagt ccaagaggat ctctgagctg     1080

atggagacac tgtctccaaa ggagcgcaag gagagcaaga agcggctgga gggcctggag     1140

gagcacatca gaaagtctac atacaccttc gacgagctga acaggtatgc cgagaagaat     1200

gtgatggcag catacatcgc agcagtggag gagtcttgtg ccgagatcat gagaaaggag     1260

aaggatctga ggaccctgct gagcaaggag gacgtgaaga tccggggcaa cagacacaat     1320

acactgatcg tgaagaacta ctttaatgcc tggaccgtgt tccggaacct gatcagaatc     1380

ctgaggcgca agtccgaggc cgagatcgac tctgacttct acgatgtgct ggacgattcc     1440

gtggaggtgc tgtctctgac atacaagggc gagaatctgt gccgcagcta tatcaccaag     1500

aagatcggct ccgacctgaa gcccgagatc gccacatacg gcagcgccct gaggcctaac     1560

agccgctggt ggtccccagg agagaagttt aatgtgaagt tccacaccat cgtgcggaga     1620

gatggccggc tgtactattt catcctgccc aagggcgcca agcctgtgga gctggaggac     1680

atggatggcg acatcgagtg tctgcagatg agaaagatcc ctaacccaac aatctttctg     1740

cccaagctgg tgttcaagga ccctgaggcc ttctttaggg ataatccaga ggccgacgag     1800

ttcgtgtttc tgagcggcat gaaggccccc gtgacaatca ccagagagac atacgaggcc     1860

tacaggtata agctgtatac cgtgggcaag ctgcgcgatg gcgaggtgtc cgaagaggag     1920

tacaagcggg ccctgctgca ggtgctgacc gcctacaagg agtttctgga gaacagaatg     1980

atctatgccg acctgaattt cggctttaag gatctggagg agtataagga cagctccgag     2040

tttatcaagc aggtggagac acacaacacc ttcatgtgct gggccaaggt gtctagctcc     2100

cagctggacg atctggtgaa gtctggcaac ggcctgctgt tcgagatctg gagcgagcgc     2160

ctggagtcct actataagta cggcaatgag aaggtgctgc ggggctatga gggcgtgctg     2220

ctgagcatcc tgaaggatga gaacctggtg tccatgcgga ccctgctgaa cagccggccc     2280

atgctggtgt accggccaaa ggagtctagc aagcctatgg tggtgcaccg ggatggcagc     2340

agagtggtgg acaggtttga taaggacggc aagtacatcc cccctgaggt gcacgacgag     2400

ctgtatcgct tctttaacaa tctgctgatc aaggagaagc tgggcgagaa ggcccggaag     2460

atcctggaca acaagaaggt gaaggtgaag gtgctggaga gcgagagagt gaagtggtcc     2520

aagttctacg atgagcagtt tgccgtgacc ttcagcgtga agaagaacgc cgattgtctg     2580

gacaccacaa aggacctgaa tgccgaagtg atggagcagt atagcgagtc caacagactg     2640

atcctgatca ggaataccac agatatcctg tactatctgg tgctggacaa gaatggcaag     2700

gtgctgaagc agagatccct gaacatcatc aatgacggcg ccagggatgt ggactggaag     2760

gagaggttcc gccaggtgac aaaggataga aacgagggct acaatgagtg ggattattcc     2820

aggacctcta acgacctgaa ggaggtgtac ctgaattatg ccctgaagga gatcgccgag     2880

gccgtgatcg agtacaacgc catcctgatc atcgagaaga tgtctaatgc ctttaaggac     2940

aagtatagct tcctggacga cgtgaccttc aagggcttcg agacaaagct gctggccaag     3000

ctgagcgatc tgcactttag gggcatcaag gacggcgagc catgttcctt cacaaacccc     3060

ctgcagctgt gccagaacga ttctaataag atcctgcagg acggcgtgat ctttatggtg     3120

ccaaattcta tgacacggag cctggacccc gacaccggct tcatctttgc catcaacgac     3180

cacaatatca ggaccaagaa ggccaagctg aactttctga gcaagttcga tcagctgaag     3240

gtgtcctctg agggctgcct gatcatgaag tacagcggcg attccctgcc tacacacaac     3300

accgacaatc gcgtgtggaa ctgctgttgc aatcacccaa tcacaaacta tgaccgggag     3360

acaaagaagg tggagttcat cgaggagccc gtggaggagc tgtcccgcgt gctggaggag     3420

aatggcatcg agacagacac cgagctgaac aagctgaatg agcgggagaa cgtgcctggc     3480

aaggtggtgg atgccatcta ctctctggtg ctgaattatc tgcgcggcac agtgagcgga     3540

gtggcaggac agagggccgt gtactatagc cctgtgaccg gcaagaagta cgatatctcc     3600

tttatccagg ccatgaacct gaataggaag tgtgactact ataggatcgg ctccaaggag     3660

aggggagagt ggaccgattt cgtggcccag ctgatcaac                            3699


<210>  116
<211>  3684
<212>  DNA
<213>  Lachnospiraceae bacterium

<400>  116
atgagcaagc tggagaagtt tacaaactgc tactccctgt ctaagaccct gaggttcaag       60

gccatccctg tgggcaagac ccaggagaac atcgacaata agcggctgct ggtggaggac      120

gagaagagag ccgaggatta taagggcgtg aagaagctgc tggatcgcta ctatctgtct      180

tttatcaacg acgtgctgca cagcatcaag ctgaagaatc tgaacaatta catcagcctg      240

ttccggaaga aaaccagaac cgagaaggag aataaggagc tggagaacct ggagatcaat      300

ctgcggaagg agatcgccaa ggccttcaag ggcaacgagg gctacaagtc cctgtttaag      360

aaggatatca tcgagacaat cctgccagag ttcctggacg ataaggacga gatcgccctg      420

gtgaacagct tcaatggctt taccacagcc ttcaccggct tctttgataa cagagagaat      480

atgttttccg aggaggccaa gagcacatcc atcgccttca ggtgtatcaa cgagaatctg      540

acccgctaca tctctaatat ggacatcttc gagaaggtgg acgccatctt tgataagcac      600

gaggtgcagg agatcaagga gaagatcctg aacagcgact atgatgtgga ggatttcttt      660

gagggcgagt tctttaactt tgtgctgaca caggagggca tcgacgtgta taacgccatc      720

atcggcggct tcgtgaccga gagcggcgag aagatcaagg gcctgaacga gtacatcaac      780

ctgtataatc agaaaaccaa gcagaagctg cctaagttta agccactgta taagcaggtg      840

ctgagcgatc gggagtctct gagcttctac ggcgagggct atacatccga tgaggaggtg      900

ctggaggtgt ttagaaacac cctgaacaag aacagcgaga tcttcagctc catcaagaag      960

ctggagaagc tgttcaagaa ttttgacgag tactctagcg ccggcatctt tgtgaagaac     1020

ggccccgcca tcagcacaat ctccaaggat atcttcggcg agtggaacgt gatccgggac     1080

aagtggaatg ccgagtatga cgatatccac ctgaagaaga aggccgtggt gaccgagaag     1140

tacgaggacg atcggagaaa gtccttcaag aagatcggct ccttttctct ggagcagctg     1200

caggagtacg ccgacgccga tctgtctgtg gtggagaagc tgaaggagat catcatccag     1260

aaggtggatg agatctacaa ggtgtatggc tcctctgaga agctgttcga cgccgatttt     1320

gtgctggaga agagcctgaa gaagaacgac gccgtggtgg ccatcatgaa ggacctgctg     1380

gattctgtga agagcttcga gaattacatc aaggccttct ttggcgaggg caaggagaca     1440

aacagggacg agtccttcta tggcgatttt gtgctggcct acgacatcct gctgaaggtg     1500

gaccacatct acgatgccat ccgcaattat gtgacccaga agccctactc taaggataag     1560

ttcaagctgt attttcagaa ccctcagttc atgggcggct gggacaagga taaggagaca     1620

gactatcggg ccaccatcct gagatacggc tccaagtact atctggccat catggataag     1680

aagtacgcca agtgcctgca gaagatcgac aaggacgatg tgaacggcaa ttacgagaag     1740

atcaactata agctgctgcc cggccctaat aagatgctgc caaaggtgtt cttttctaag     1800

aagtggatgg cctactataa ccccagcgag gacatccaga agatctacaa gaatggcaca     1860

ttcaagaagg gcgatatgtt taacctgaat gactgtcaca agctgatcga cttctttaag     1920

gatagcatct cccggtatcc aaagtggtcc aatgcctacg atttcaactt ttctgagaca     1980

gagaagtata aggacatcgc cggcttttac agagaggtgg aggagcaggg ctataaggtg     2040

agcttcgagt ctgccagcaa gaaggaggtg gataagctgg tggaggaggg caagctgtat     2100

atgttccaga tctataacaa ggacttttcc gataagtctc acggcacacc caatctgcac     2160

accatgtact tcaagctgct gtttgacgag aacaatcacg gacagatcag gctgagcgga     2220

ggagcagagc tgttcatgag gcgcgcctcc ctgaagaagg aggagctggt ggtgcaccca     2280

gccaactccc ctatcgccaa caagaatcca gataatccca agaaaaccac aaccctgtcc     2340

tacgacgtgt ataaggataa gaggttttct gaggaccagt acgagctgca catcccaatc     2400

gccatcaata agtgccccaa gaacatcttc aagatcaata cagaggtgcg cgtgctgctg     2460

aagcacgacg ataaccccta tgtgatcggc atcgataggg gcgagcgcaa tctgctgtat     2520

atcgtggtgg tggacggcaa gggcaacatc gtggagcagt attccctgaa cgagatcatc     2580

aacaacttca acggcatcag gatcaagaca gattaccact ctctgctgga caagaaggag     2640

aaggagaggt tcgaggcccg ccagaactgg acctccatcg agaatatcaa ggagctgaag     2700

gccggctata tctctcaggt ggtgcacaag atctgcgagc tggtggagaa gtacgatgcc     2760

gtgatcgccc tggaggacct gaactctggc tttaagaata gccgcgtgaa ggtggagaag     2820

caggtgtatc agaagttcga gaagatgctg atcgataagc tgaactacat ggtggacaag     2880

aagtctaatc cttgtgcaac aggcggcgcc ctgaagggct atcagatcac caataagttc     2940

gagagcttta agtccatgtc tacccagaac ggcttcatct tttacatccc tgcctggctg     3000

acatccaaga tcgatccatc taccggcttt gtgaacctgc tgaaaaccaa gtataccagc     3060

atcgccgatt ccaagaagtt catcagctcc tttgacagga tcatgtacgt gcccgaggag     3120

gatctgttcg agtttgccct ggactataag aacttctctc gcacagacgc cgattacatc     3180

aagaagtgga agctgtactc ctacggcaac cggatcagaa tcttccggaa tcctaagaag     3240

aacaacgtgt tcgactggga ggaggtgtgc ctgaccagcg cctataagga gctgttcaac     3300

aagtacggca tcaattatca gcagggcgat atcagagccc tgctgtgcga gcagtccgac     3360

aaggccttct actctagctt tatggccctg atgagcctga tgctgcagat gcggaacagc     3420

atcacaggcc gcaccgacgt ggattttctg atcagccctg tgaagaactc cgacggcatc     3480

ttctacgata gccggaacta tgaggcccag gagaatgcca tcctgccaaa gaacgccgac     3540

gccaatggcg cctataacat cgccagaaag gtgctgtggg ccatcggcca gttcaagaag     3600

gccgaggacg agaagctgga taaggtgaag atcgccatct ctaacaagga gtggctggag     3660

tacgcccaga ccagcgtgaa gcac                                            3684


<210>  117
<211>  3900
<212>  DNA
<213>  Francisella tularensis

<400>  117
atgagcatct accaggagtt cgtcaacaag tattcactga gtaagacact gcggttcgag       60

ctgatcccac agggcaagac actggagaac atcaaggccc gaggcctgat tctggacgat      120

gagaagcggg caaaagacta taagaaagcc aagcagatca ttgataaata ccaccagttc      180

tttatcgagg aaattctgag ctccgtgtgc atcagtgagg atctgctgca gaattactca      240

gacgtgtact tcaagctgaa gaagagcgac gatgacaacc tgcagaagga cttcaagtcc      300

gccaaggaca ccatcaagaa acagattagc gagtacatca aggactccga aaagtttaaa      360

aatctgttca accagaatct gatcgatgct aagaaaggcc aggagtccga cctgatcctg      420

tggctgaaac agtctaagga caatgggatt gaactgttca aggctaactc cgatatcact      480

gatattgacg aggcactgga aatcatcaag agcttcaagg gatggaccac atactttaaa      540

ggcttccacg agaaccgcaa gaacgtgtac tccagcaacg acattcctac ctccatcatc      600

taccgaatcg tcgatgacaa tctgccaaag ttcctggaga acaaggccaa atatgaatct      660

ctgaaggaca aagctcccga ggcaattaat tacgaacaga tcaagaaaga tctggctgag      720

gaactgacat tcgatatcga ctataagact agcgaggtga accagagggt cttttccctg      780

gacgaggtgt ttgaaatcgc caatttcaac aattacctga accagtccgg cattactaaa      840

ttcaatacca tcattggcgg gaagtttgtg aacggggaga ataccaagcg caagggaatt      900

aacgaataca tcaatctgta tagccagcag atcaacgaca aaactctgaa gaaatacaag      960

atgtctgtgc tgttcaaaca gatcctgagt gataccgagt ccaagtcttt tgtcattgat     1020

aaactggaag atgactcaga cgtggtcact accatgcaga gcttttatga gcagatcgcc     1080

gctttcaaga cagtggagga aaaatctatt aaggaaactc tgagtctgct gttcgatgac     1140

ctgaaagccc agaagctgga cctgagtaag atctacttca aaaacgataa gagtctgaca     1200

gacctgtcac agcaggtgtt tgatgactat tccgtgattg ggaccgccgt cctggagtac     1260

attacacagc agatcgctcc aaagaacctg gataatccct ctaagaaaga gcaggaactg     1320

atcgctaaga aaaccgagaa ggcaaaatat ctgagtctgg aaacaattaa gctggcactg     1380

gaggagttca acaagcacag ggatattgac aaacagtgcc gctttgagga aatcctggcc     1440

aacttcgcag ccatccccat gatttttgat gagatcgccc agaacaaaga caatctggct     1500

cagatcagta ttaagtacca gaaccagggc aagaaagacc tgctgcaggc ttcagcagaa     1560

gatgacgtga aagccatcaa ggatctgctg gaccagacca acaatctgct gcacaagctg     1620

aaaatcttcc atattagtca gtcagaggat aaggctaata tcctggataa agacgaacac     1680

ttctacctgg tgttcgagga atgttacttc gagctggcaa acattgtccc cctgtataac     1740

aagattagga actacatcac acagaagcct tactctgacg agaagtttaa actgaacttc     1800

gaaaatagta ccctggccaa cgggtgggat aagaacaagg agcctgacaa cacagctatc     1860

ctgttcatca aggatgacaa gtactatctg ggagtgatga ataagaaaaa caataagatc     1920

ttcgatgaca aagccattaa ggagaacaaa ggggaaggat acaagaaaat cgtgtataag     1980

ctgctgcccg gcgcaaataa gatgctgcct aaggtgttct tcagcgccaa gagtatcaaa     2040

ttctacaacc catccgagga catcctgcgg attagaaatc actcaacaca tactaagaac     2100

gggagccccc agaagggata tgagaaattt gagttcaaca tcgaggattg caggaagttt     2160

attgacttct acaagcagag catctccaaa caccctgaat ggaaggattt tggcttccgg     2220

ttttccgaca cacagagata taactctatc gacgagttct accgcgaggt ggaaaatcag     2280

gggtataagc tgacttttga gaacatttct gaaagttaca tcgacagcgt ggtcaatcag     2340

ggaaagctgt acctgttcca gatctataac aaagattttt cagcatacag caagggcaga     2400

ccaaacctgc atacactgta ctggaaggcc ctgttcgatg agaggaatct gcaggacgtg     2460

gtctataaac tgaacggaga ggccgaactg ttttaccgga agcagtctat tcctaagaaa     2520

atcactcacc cagctaagga ggccatcgct aacaagaaca aggacaatcc taagaaagag     2580

agcgtgttcg aatacgatct gattaaggac aagcggttca ccgaagataa gttctttttc     2640

cattgtccaa tcaccattaa cttcaagtca agcggcgcta acaagttcaa cgacgagatc     2700

aatctgctgc tgaaggaaaa agcaaacgat gtgcacatcc tgagcattga ccgaggagag     2760

cggcatctgg cctactatac cctggtggat ggcaaaggga atatcattaa gcaggataca     2820

ttcaacatca ttggcaatga ccggatgaaa accaactacc acgataaact ggctgcaatc     2880

gagaaggata gagactcagc taggaaggac tggaagaaaa tcaacaacat taaggagatg     2940

aaggaaggct atctgagcca ggtggtccat gagattgcaa agctggtcat cgaatacaat     3000

gccattgtgg tgttcgagga tctgaacttc ggctttaaga gggggcgctt taaggtggaa     3060

aaacaggtct atcagaagct ggagaaaatg ctgatcgaaa agctgaatta cctggtgttt     3120

aaagataacg agttcgacaa gaccggaggc gtcctgagag cctaccagct gacagctccc     3180

tttgaaactt tcaagaaaat gggaaaacag acaggcatca tctactatgt gccagccgga     3240

ttcacttcca agatctgccc cgtgaccggc tttgtcaacc agctgtaccc taaatatgag     3300

tcagtgagca agtcccagga atttttcagc aagttcgata agatctgtta taatctggac     3360

aaggggtact tcgagttttc cttcgattac aagaacttcg gcgacaaggc cgctaagggg     3420

aaatggacca ttgcctcctt cggatctcgc ctgatcaact ttcgaaattc cgataaaaac     3480

cacaattggg acactaggga ggtgtaccca accaaggagc tggaaaagct gctgaaagac     3540

tactctatcg agtatggaca tggcgaatgc atcaaggcag ccatctgtgg cgagagtgat     3600

aagaaatttt tcgccaagct gacctcagtg ctgaatacaa tcctgcagat gcggaactca     3660

aagaccggga cagaactgga ctatctgatt agccccgtgg ctgatgtcaa cggaaacttc     3720

ttcgacagca gacaggcacc caaaaatatg cctcaggatg cagacgccaa cggggcctac     3780

cacatcgggc tgaagggact gatgctgctg ggccggatca agaacaatca ggaggggaag     3840

aagctgaacc tggtcattaa gaacgaggaa tacttcgagt ttgtccagaa tagaaataac     3900


<210>  118
<211>  4431
<212>  DNA
<213>  Peregrinibacteria

<400>  118
atgtccaact tctttaagaa tttcaccaac ctgtatgagc tgtccaagac actgaggttt       60

gagctgaagc ccgtgggcga caccctgaca aacatgaagg accacctgga gtacgatgag      120

aagctgcaga ccttcctgaa ggatcagaat atcgacgatg cctatcaggc cctgaagcct      180

cagttcgacg agatccacga ggagtttatc acagattctc tggagagcaa gaaggccaag      240

gagatcgact tctccgagta cctggatctg tttcaggaga agaaggagct gaacgactct      300

gagaagaagc tgcgcaacaa gatcggcgag acattcaaca aggccggcga gaagtggaag      360

aaggagaagt accctcagta tgagtggaag aagggctcca agatcgccaa tggcgccgac      420

atcctgtctt gccaggatat gctgcagttt atcaagtata agaacccaga ggatgagaag      480

atcaagaatt acatcgacga tacactgaag ggcttcttta cctatttcgg cggctttaat      540

cagaacaggg ccaactacta tgagacaaag aaggaggcct ccaccgcagt ggcaacaagg      600

atcgtgcacg agaacctgcc aaagttctgt gacaatgtga tccagtttaa gcacatcatc      660

aagcggaaga aggatggcac cgtggagaaa accgagagaa agaccgagta cctgaacgcc      720

taccagtatc tgaagaacaa taacaagatc acacagatca aggacgccga gacagagaag      780

atgatcgagt ctacacccat cgccgagaag atcttcgacg tgtactactt cagcagctgc      840

ctgagccaga agcagatcga ggagtacaac cggatcatcg gccactataa tctgctgatc      900

aacctgtata accaggccaa gagatctgag ggcaagcacc tgagcgccaa cgagaagaag      960

tataaggacc tgcctaagtt caagaccctg tataagcaga tcggctgcgg caagaagaag     1020

gacctgtttt acacaatcaa gtgtgatacc gaggaggagg ccaataagtc ccggaacgag     1080

ggcaaggagt cccactctgt ggaggagatc atcaacaagg cccaggaggc catcaataag     1140

tacttcaagt ctaataacga ctgtgagaat atcaacaccg tgcccgactt catcaactat     1200

atcctgacaa aggagaatta cgagggcgtg tattggagca aggccgccat gaacaccatc     1260

tccgacaagt acttcgccaa ttatcacgac ctgcaggata gactgaagga ggccaaggtg     1320

tttcagaagg ccgataagaa gtccgaggac gatatcaaga tcccagaggc catcgagctg     1380

tctggcctgt tcggcgtgct ggacagcctg gccgattggc agaccacact gtttaagtct     1440

agcatcctga gcaacgagga caagctgaag atcatcacag attcccagac cccctctgag     1500

gccctgctga agatgatctt caatgacatc gagaagaaca tggagtcctt tctgaaggag     1560

acaaacgata tcatcaccct gaagaagtat aagggcaata aggagggcac cgagaagatc     1620

aagcagtggt tcgactatac actggccatc aaccggatgc tgaagtactt tctggtgaag     1680

gagaataaga tcaagggcaa ctccctggat accaatatct ctgaggccct gaaaaccctg     1740

atctacagcg acgatgccga gtggttcaag tggtacgacg ccctgagaaa ctatctgacc     1800

cagaagcctc aggatgaggc caaggagaat aagctgaagc tgaatttcga caacccatct     1860

ctggccggcg gctgggatgt gaacaaggag tgcagcaatt tttgcgtgat cctgaaggac     1920

aagaacgaga agaagtacct ggccatcatg aagaagggcg agaataccct gttccagaag     1980

gagtggacag agggccgggg caagaacctg acaaagaagt ctaatccact gttcgagatc     2040

aataactgcg agatcctgag caagatggag tatgactttt gggccgacgt gagcaagatg     2100

atccccaagt gtagcaccca gctgaaggcc gtggtgaacc acttcaagca gtccgacaat     2160

gagttcatct ttcctatcgg ctacaaggtg acaagcggcg agaagtttag ggaggagtgc     2220

aagatctcca agcaggactt cgagctgaat aacaaggtgt ttaataagaa cgagctgagc     2280

gtgaccgcca tgcgctacga tctgtcctct acacaggaga agcagtatat caaggccttc     2340

cagaaggagt actgggagct gctgtttaag caggagaagc gggacaccaa gctgacaaat     2400

aacgagatct tcaacgagtg gatcaatttt tgcaacaaga agtatagcga gctgctgtcc     2460

tgggagagaa agtacaagga tgccctgacc aattggatca acttctgtaa gtactttctg     2520

agcaagtatc ccaagaccac actgttcaac tactctttta aggagagcga gaattataac     2580

tccctggacg agttctaccg ggacgtggat atctgttctt acaagctgaa tatcaacacc     2640

acaatcaata agagcatcct ggatagactg gtggaggagg gcaagctgta cctgtttgag     2700

atcaagaatc aggacagcaa cgatggcaag tccatcggcc acaagaataa cctgcacacc     2760

atctactgga acgccatctt cgagaatttt gacaacaggc ctaagctgaa tggcgaggcc     2820

gagatcttct atcgcaaggc catctccaag gataagctgg gcatcgtgaa gggcaagaaa     2880

accaagaacg gcaccgagat catcaagaat tacagattca gcaaggagaa gtttatcctg     2940

cacgtgccaa tcaccctgaa cttctgctcc aataacgagt atgtgaatga catcgtgaac     3000

acaaagttct acaatttttc caacctgcac tttctgggca tcgatagggg cgagaagcac     3060

ctggcctact attctctggt gaataagaac ggcgagatcg tggaccaggg cacactgaac     3120

ctgcctttca ccgacaagga tggcaatcag cgcagcatca agaaggagaa gtacttttat     3180

aacaagcagg aggacaagtg ggaggccaag gaggtggatt gttggaatta taacgacctg     3240

ctggatgcca tggcctctaa ccgggacatg gccagaaaga attggcagag gatcggcacc     3300

atcaaggagg ccaagaacgg ctacgtgagc ctggtcatca ggaagatcgc cgatctggcc     3360

gtgaataacg agcgccccgc cttcatcgtg ctggaggacc tgaatacagg ctttaagcgg     3420

tccagacaga agatcgataa gagcgtgtac cagaagttcg agctggccct ggccaagaag     3480

ctgaactttc tggtggacaa gaatgccaag cgcgatgaga tcggctcccc tacaaaggcc     3540

ctgcagctga ccccccctgt gaataactac ggcgacattg agaacaagaa gcaggccggc     3600

atcatgctgt atacccgggc caattatacc tctcagacag atccagccac aggctggaga     3660

aagaccatct atctgaaggc cggccccgag gagacaacat acaagaagga cggcaagatc     3720

aagaacaaga gcgtgaagga ccagatcatc gagacattca ccgatatcgg ctttgacggc     3780

aaggattact atttcgagta cgacaagggc gagtttgtgg atgagaaaac cggcgagatc     3840

aagcccaaga agtggcggct gtactccggc gagaatggca agtccctgga caggttccgc     3900

ggagagaggg agaaggataa gtatgagtgg aagatcgaca agatcgatat cgtgaagatc     3960

ctggacgatc tgttcgtgaa ttttgacaag aacatcagcc tgctgaagca gctgaaggag     4020

ggcgtggagc tgacccggaa taacgagcac ggcacaggcg agtccctgag attcgccatc     4080

aacctgatcc agcagatccg gaataccggc aataacgaga gagacaacga tttcatcctg     4140

tccccagtga gggacgagaa tggcaagcac tttgactctc gcgagtactg ggataaggag     4200

acaaagggcg agaagatcag catgcccagc tccggcgatg ccaatggcgc cttcaacatc     4260

gcccggaagg gcatcatcat gaacgcccac atcctggcca atagcgactc caaggatctg     4320

tccctgttcg tgtctgacga ggagtgggat ctgcacctga ataacaagac cgagtggaag     4380

aagcagctga acatcttttc tagcaggaag gccatggcca agcgcaagaa g              4431


<210>  119
<211>  4056
<212>  DNA
<213>  Parcubacteria

<400>  119
atggagaaca tcttcgacca gtttatcggc aagtacagcc tgtccaagac cctgagattc       60

gagctgaagc ccgtgggcaa gacagaggac ttcctgaaga tcaacaaggt gtttgagaag      120

gatcagacca tcgacgatag ctacaatcag gccaagttct attttgattc cctgcaccag      180

aagtttatcg acgccgccct ggcctccgat aagacatccg agctgtcttt ccagaacttt      240

gccgacgtgc tggagaagca gaataagatc atcctggata agaagagaga gatgggcgcc      300

ctgaggaagc gcgacaagaa cgccgtgggc atcgataggc tgcagaagga gatcaatgac      360

gccgaggata tcatccagaa ggagaaggag aagatctaca aggacgtgcg caccctgttc      420

gataacgagg ccgagtcttg gaaaacctac tatcaggagc gggaggtgga cggcaagaag      480

atcaccttca gcaaggccga cctgaagcag aagggcgccg attttctgac agccgccggc      540

atcctgaagg tgctgaagta tgagttcccc gaggagaagg agaaggagtt tcaggccaag      600

aaccagccct ccctgttcgt ggaggagaag gagaatcctg gccagaagag gtacatcttc      660

gactcttttg ataagttcgc cggctatctg accaagtttc agcagacaaa gaagaatctg      720

tacgcagcag acggcaccag cacagcagtg gccacccgca tcgccgataa ctttatcatc      780

ttccaccaga ataccaaggt gttccgggac aagtacaaga acaatcacac agacctgggc      840

ttcgatgagg agaacatctt tgagatcgag aggtataaga attgcctgct gcagcgcgag      900

atcgagcaca tcaagaatga gaatagctac aacaagatca tcggccggat caataagaag      960

atcaaggagt atcgggacca gaaggccaag gataccaagc tgacaaagtc cgacttccct     1020

ttctttaaga acctggataa gcagatcctg ggcgaggtgg agaaggagaa gcagctgatc     1080

gagaaaaccc gggagaaaac cgaggaggac gtgctgatcg agcggttcaa ggagttcatc     1140

gagaacaatg aggagaggtt caccgccgcc aagaagctga tgaatgcctt ctgtaacggc     1200

gagtttgagt ccgagtacga gggcatctat ctgaagaata aggccatcaa cacaatctcc     1260

cggagatggt tcgtgtctga cagagatttt gagctgaagc tgcctcagca gaagtccaag     1320

aacaagtctg agaagaatga gccaaaggtg aagaagttca tctccatcgc cgagatcaag     1380

aacgccgtgg aggagctgga cggcgatatc tttaaggccg tgttctacga caagaagatc     1440

atcgcccagg gcggctctaa gctggagcag ttcctggtca tctggaagta cgagtttgag     1500

tatctgttcc gggacatcga gagagagaac ggcgagaagc tgctgggcta tgatagctgc     1560

ctgaagatcg ccaagcagct gggcatcttc ccacaggaga aggaggcccg cgagaaggca     1620

accgccgtga tcaagaatta cgccgacgcc ggcctgggca tcttccagat gatgaagtat     1680

ttttctctgg acgataagga tcggaagaac acccccggcc agctgagcac aaatttctac     1740

gccgagtatg acggctacta caaggatttc gagtttatca agtactacaa cgagtttagg     1800

aacttcatca ccaagaagcc tttcgacgag gataagatca agctgaactt tgagaatggc     1860

gccctgctga agggctggga cgagaacaag gagtacgatt tcatgggcgt gatcctgaag     1920

aaggagggcc gcctgtatct gggcatcatg cacaagaacc accggaagct gtttcagtcc     1980

atgggcaatg ccaagggcga caacgccaat agataccaga agatgatcta taagcagatc     2040

gccgacgcct ctaaggatgt gcccaggctg ctgctgacca gcaagaaggc catggagaag     2100

ttcaagcctt cccaggagat cctgagaatc aagaaggaga aaaccttcaa gcgggagagc     2160

aagaactttt ccctgagaga tctgcacgcc ctgatcgagt actataggaa ctgcatccct     2220

cagtacagca attggtcctt ttatgacttc cagtttcagg ataccggcaa gtaccagaat     2280

atcaaggagt tcacagacga tgtgcagaag tacggctata agatctcctt tcgcgacatc     2340

gacgatgagt atatcaatca ggccctgaac gagggcaaga tgtacctgtt cgaggtggtg     2400

aacaaggata tctataacac caagaatggc tccaagaatc tgcacacact gtactttgag     2460

cacatcctgt ctgccgagaa cctgaatgac ccagtgttca agctgtctgg catggccgag     2520

atctttcagc ggcagcccag cgtgaacgaa agagagaaga tcaccacaca gaagaatcag     2580

tgtatcctgg acaagggcga tagagcctac aagtataggc gctacaccga gaagaagatc     2640

atgttccaca tgagcctggt gctgaacaca ggcaagggcg agatcaagca ggtgcagttt     2700

aataagatca tcaaccagag gatcagctcc tctgacaacg agatgagggt gaatgtgatc     2760

ggcatcgatc gcggcgagaa gaacctgctg tactatagcg tggtgaagca gaatggcgag     2820

atcatcgagc aggcctccct gaacgagatc aatggcgtga actaccggga caagctgatc     2880

gagagggaga aggagcgcct gaagaaccgg cagagctgga agcctgtggt gaagatcaag     2940

gatctgaaga agggctacat ctcccacgtg atccacaaga tctgccagct gatcgagaag     3000

tattctgcca tcgtggtgct ggaggacctg aatatgagat tcaagcagat caggggagga     3060

atcgagcgga gcgtgtacca gcagttcgag aaggccctga tcgataagct gggctatctg     3120

gtgtttaagg acaacaggga tctgagggca ccaggaggcg tgctgaatgg ctaccagctg     3180

tctgccccct ttgtgagctt cgagaagatg cgcaagcaga ccggcatcct gttctacaca     3240

caggccgagt ataccagcaa gacagaccca atcaccggct ttcggaagaa cgtgtatatc     3300

tctaatagcg cctccctgga taagatcaag gaggccgtga agaagttcga cgccatcggc     3360

tgggatggca aggagcagtc ttacttcttt aagtacaacc cttacaacct ggccgacgag     3420

aagtataaga actctaccgt gagcaaggag tgggccatct ttgccagcgc cccaagaatc     3480

cggagacaga agggcgagga cggctactgg aagtatgata gggtgaaagt gaatgaggag     3540

ttcgagaagc tgctgaaggt ctggaatttt gtgaacccaa aggccacaga tatcaagcag     3600

gagatcatca agaaggagaa ggcaggcgac ctgcagggag agaaggagct ggatggccgg     3660

ctgagaaact tttggcactc tttcatctac ctgtttaacc tggtgctgga gctgcgcaat     3720

tctttcagcc tgcagatcaa gatcaaggca ggagaagtga tcgcagtgga cgagggcgtg     3780

gacttcatcg ccagcccagt gaagcccttc tttaccacac ccaaccctta catcccctcc     3840

aacctgtgct ggctggccgt ggagaatgca gacgcaaacg gagcctataa tatcgccagg     3900

aagggcgtga tgatcctgaa gaagatccgc gagcacgcca agaaggaccc cgagttcaag     3960

aagctgccaa acctgtttat cagcaatgca gagtgggacg aggcagcccg ggattggggc     4020

aagtacgcag gcaccacagc cctgaacctg gaccac                               4056


<210>  120
<211>  3618
<212>  DNA
<213>  Lachnospiraceae bacterium

<400>  120
atgtactatg agtccctgac caagcagtac cccgtgtcta agacaatccg gaatgagctg       60

atccctatcg gcaagacact ggataacatc cgccagaaca atatcctgga gagcgacgtg      120

aagcggaagc agaactacga gcacgtgaag ggcatcctgg atgagtatca caagcagctg      180

atcaacgagg ccctggacaa ttgcaccctg ccatccctga agatcgccgc cgagatctac      240

ctgaagaatc agaaggaggt gtctgacaga gaggatttca acaagacaca ggacctgctg      300

aggaaggagg tggtggagaa gctgaaggcc cacgagaact ttaccaagat cggcaagaag      360

gacatcctgg atctgctgga gaagctgcct tccatctctg aggacgatta caatgccctg      420

gagagcttcc gcaactttta cacctatttc acatcctaca acaaggtgcg ggagaatctg      480

tattctgata aggagaagag ctccacagtg gcctacagac tgatcaacga gaatttccca      540

aagtttctgg acaatgtgaa gagctatagg tttgtgaaaa ccgcaggcat cctggcagat      600

ggcctgggag aggaggagca ggactccctg ttcatcgtgg agacattcaa caagaccctg      660

acacaggacg gcatcgatac ctacaattct caagtgggca agatcaactc tagcatcaat      720

ctgtataacc agaagaatca gaaggccaat ggcttcagaa agatccccaa gatgaagatg      780

ctgtataagc agatcctgtc cgatagggag gagtctttca tcgacgagtt tcagagcgat      840

gaggtgctga tcgacaacgt ggagtcttat ggcagcgtgc tgatcgagtc tctgaagtcc      900

tctaaggtga gcgccttctt tgatgccctg agagagtcta agggcaagaa cgtgtacgtg      960

aagaatgacc tggccaagac agccatgagc aacatcgtgt tcgagaattg gaggaccttt     1020

gacgatctgc tgaaccagga gtacgacctg gccaacgaga acaagaagaa ggacgataag     1080

tatttcgaga agcgccagaa ggagctgaag aagaataaga gctactccct ggagcacctg     1140

tgcaacctgt ccgaggattc ttgtaacctg atcgagaatt atatccacca gatctccgac     1200

gatatcgaga atatcatcat caacaatgag acattcctgc gcatcgtgat caatgagcac     1260

gacaggtccc gcaagctggc caagaaccgg aaggccgtga aggccatcaa ggactttctg     1320

gattctatca aggtgctgga gcgggagctg aagctgatca acagctccgg ccaggagctg     1380

gagaaggatc tgatcgtgta ctctgcccac gaggagctgc tggtggagct gaagcaggtg     1440

gacagcctgt ataacatgac cagaaattat ctgacaaaga agcctttctc taccgagaag     1500

gtgaagctga actttaatcg cagcacactg ctgaacggct gggatcggaa taaggagaca     1560

gacaacctgg gcgtgctgct gctgaaggac ggcaagtact atctgggcat catgaacaca     1620

agcgccaata aggccttcgt gaatccccct gtggccaaga ccgagaaggt gtttaagaag     1680

gtggattaca agctgctgcc agtgcccaac cagatgctgc caaaggtgtt ctttgccaag     1740

agcaatatcg acttctataa cccctctagc gagatctact ccaattataa gaagggcacc     1800

cacaagaagg gcaatatgtt ttccctggag gattgtcaca acctgatcga cttctttaag     1860

gagtctatca gcaagcacga ggactggagc aagttcggct ttaagttcag cgatacagcc     1920

tcctacaacg acatctccga gttctatcgc gaggtggaga agcagggcta caagctgacc     1980

tatacagaca tcgatgagac atacatcaat gatctgatcg agcggaacga gctgtacctg     2040

ttccagatct ataataagga ctttagcatg tactccaagg gcaagctgaa cctgcacaca     2100

ctgtatttca tgatgctgtt tgatcagcgc aatatcgacg acgtggtgta taagctgaac     2160

ggagaggcag aggtgttcta taggccagcc tccatctctg aggacgagct gatcatccac     2220

aaggccggcg aggagatcaa gaacaagaat cctaaccggg ccagaaccaa ggagacaagc     2280

accttcagct acgacatcgt gaaggataag cggtatagca aggataagtt taccctgcac     2340

atccccatca caatgaactt cggcgtggat gaggtgaagc ggttcaacga cgccgtgaac     2400

agcgccatcc ggatcgatga gaatgtgaac gtgatcggca tcgaccgggg cgagagaaat     2460

ctgctgtacg tggtggtcat cgactctaag ggcaacatcc tggagcagat ctccctgaac     2520

tctatcatca ataaggagta cgacatcgag acagattatc acgcactgct ggatgagagg     2580

gagggcggca gagataaggc ccggaaggac tggaacaccg tggagaatat cagggacctg     2640

aaggccggct acctgagcca ggtggtgaac gtggtggcca agctggtgct gaagtataat     2700

gccatcatct gcctggagga cctgaacttt ggcttcaaga ggggccgcca gaaggtggag     2760

aagcaggtgt accagaagtt cgagaagatg ctgatcgata agctgaatta cctggtcatc     2820

gacaagagcc gcgagcagac atcccctaag gagctgggag gcgccctgaa cgcactgcag     2880

ctgacctcta agttcaagag ctttaaggag ctgggcaagc agtccggcgt gatctactat     2940

gtgcctgcct acctgacctc taagatcgat ccaaccacag gcttcgccaa tctgttttat     3000

atgaagtgtg agaacgtgga gaagtccaag agattctttg acggctttga tttcatcagg     3060

ttcaacgccc tggagaacgt gttcgagttc ggctttgact accggagctt cacccagagg     3120

gcctgcggca tcaattccaa gtggaccgtg tgcaccaacg gcgagcgcat catcaagtat     3180

cggaatccag ataagaacaa tatgttcgac gagaaggtgg tggtggtgac cgatgagatg     3240

aagaacctgt ttgagcagta caagatcccc tatgaggatg gcagaaatgt gaaggacatg     3300

atcatcagca acgaggaggc cgagttctac cggagactgt ataggctgct gcagcagacc     3360

ctgcagatga gaaacagcac ctccgacggc acaagggatt acatcatctc ccctgtgaag     3420

aataagagag aggcctactt caacagcgag ctgtccgacg gctctgtgcc aaaggacgcc     3480

gatgccaacg gcgcctacaa tatcgccaga aagggcctgt gggtgctgga gcagatcagg     3540

cagaagagcg agggcgagaa gatcaatctg gccatgacca acgccgagtg gctggagtat     3600

gcccagacac acctgctg                                                   3618


<210>  121
<211>  3714
<212>  DNA
<213>  Candidatus Methanoplasma termitum

<400>  121
atgaacaatt acgacgagtt caccaagctg tatcctatcc agaaaaccat ccggtttgag       60

ctgaagccac agggcagaac catggagcac ctggagacat tcaacttctt tgaggaggac      120

cgggatagag ccgagaagta taagatcctg aaggaggcca tcgacgagta ccacaagaag      180

tttatcgatg agcacctgac caatatgtcc ctggattgga actctctgaa gcagatcagc      240

gagaagtact ataagagcag ggaggagaag gacaagaagg tgttcctgtc cgagcagaag      300

aggatgcgcc aggagatcgt gtctgagttt aagaaggacg atcgcttcaa ggacctgttt      360

tccaagaagc tgttctctga gctgctgaag gaggagatct acaagaaggg caaccaccag      420

gagatcgacg ccctgaagag cttcgataag ttttccggct atttcatcgg cctgcacgag      480

aataggaaga acatgtactc cgacggcgat gagatcaccg ccatctccaa tcgcatcgtg      540

aatgagaact tccccaagtt tctggataac ctgcagaagt accaggaggc caggaagaag      600

tatcctgagt ggatcatcaa ggccgagagc gccctggtgg cccacaatat caagatggac      660

gaggtgttct ccctggagta ctttaataag gtgctgaacc aggagggcat ccagcggtac      720

aacctggccc tgggcggcta tgtgaccaag agcggcgaga agatgatggg cctgaatgat      780

gccctgaacc tggcccacca gtccgagaag agctccaagg gcagaatcca catgaccccc      840

ctgttcaagc agatcctgtc cgagaaggag tccttctctt acatccccga cgtgtttaca      900

gaggattctc agctgctgcc tagcatcggc ggcttctttg cccagatcga gaatgacaag      960

gatggcaaca tcttcgaccg ggccctggag ctgatctcta gctacgccga gtatgatacc     1020

gagcggatct atatcagaca ggccgacatc aatagagtgt ccaacgtgat ctttggagag     1080

tggggcaccc tgggaggcct gatgagggag tacaaggccg actctatcaa tgatatcaac     1140

ctggagcgca catgcaagaa ggtggacaag tggctggatt ctaaggagtt tgccctgagc     1200

gatgtgctgg aggccatcaa gaggaccggc aacaatgacg ccttcaacga gtatatctcc     1260

aagatgcgga cagccagaga gaagatcgat gccgcccgca aggagatgaa gttcatcagc     1320

gagaagatct ccggcgatga ggagtctatc cacatcatca agaccctgct ggacagcgtg     1380

cagcagttcc tgcacttctt taatctgttt aaggcaaggc aggacatccc actggatgga     1440

gccttctacg ccgagtttga cgaggtgcac agcaagctgt ttgccatcgt gcccctgtat     1500

aacaaggtgc ggaactatct gaccaagaac aatctgaaca caaagaagat caagctgaat     1560

ttcaagaacc ctacactggc caatggctgg gaccagaaca aggtgtacga ttatgcctcc     1620

ctgatctttc tgcgggacgg caattactat ctgggcatca tcaatcctaa gagaaagaag     1680

aacatcaagt tcgagcaggg ctctggcaac ggccccttct accggaagat ggtgtataag     1740

cagatccccg gccctaataa gaacctgcca agagtgttcc tgacctccac aaagggcaag     1800

aaggagtata agccctctaa ggagatcatc gagggctacg aggccgacaa gcacatcagg     1860

ggcgataagt tcgacctgga tttttgtcac aagctgatcg atttctttaa ggagtccatc     1920

gagaagcaca aggactggtc taagttcaac ttctacttca gcccaaccga gagctatggc     1980

gacatctctg agttctacct ggatgtggag aagcagggct atcgcatgca ctttgagaat     2040

atcagcgccg agacaatcga cgagtatgtg gagaagggcg atctgtttct gttccagatc     2100

tacaacaagg attttgtgaa ggccgccacc ggcaagaagg acatgcacac aatctactgg     2160

aatgccgcct tcagccccga gaacctgcag gacgtggtgg tgaagctgaa cggcgaggcc     2220

gagctgtttt atagggacaa gtccgatatc aaggagatcg tgcaccgcga gggcgagatc     2280

ctggtgaata ggacctacaa cggccgcaca ccagtgcccg acaagatcca caagaagctg     2340

accgattatc acaatggccg gacaaaggac ctgggcgagg ccaaggagta cctggataag     2400

gtgagatact tcaaggccca ctatgacatc accaaggatc ggagatacct gaacgacaag     2460

atctatttcc acgtgcctct gaccctgaac ttcaaggcca acggcaagaa gaatctgaac     2520

aagatggtca tcgagaagtt cctgtccgat gagaaggccc acatcatcgg catcgacagg     2580

ggcgagcgca atctgctgta ctattccatc atcgacaggt ctggcaagat catcgatcag     2640

cagagcctga atgtgatcga cggctttgat tatcgggaga agctgaacca gagagagatc     2700

gagatgaagg atgcccgcca gtcttggaac gccatcggca agatcaagga cctgaaggag     2760

ggctacctga gcaaggccgt gcacgagatc accaagatgg ccatccagta taatgccatc     2820

gtggtcatgg aggagctgaa ctacggcttc aagcggggcc ggttcaaggt ggagaagcag     2880

atctatcaga agttcgagaa tatgctgatc gataagatga actacctggt gtttaaggac     2940

gcacctgatg agtccccagg aggcgtgctg aatgcctacc agctgacaaa cccactggag     3000

tctttcgcca agctgggcaa gcagaccggc atcctgtttt acgtgccagc cgcctataca     3060

tccaagatcg accccaccac aggcttcgtg aatctgttta acacctcctc taagacaaac     3120

gcccaggagc ggaaggagtt cctgcagaag tttgagagca tctcctattc tgccaaggat     3180

ggcggcatct ttgccttcgc ctttgactac agaaagttcg gcaccagcaa gacagatcac     3240

aagaacgtgt ggaccgccta tacaaacggc gagaggatgc gctacatcaa ggagaagaag     3300

cggaatgagc tgtttgaccc ttctaaggag atcaaggagg ccctgaccag ctccggcatc     3360

aagtacgatg gcggccagaa catcctgcca gacatcctga ggagcaacaa taacggcctg     3420

atctacacaa tgtattctag cttcatcgcc gccatccaga tgcgcgtgta cgacggcaag     3480

gaggattata tcatcagccc catcaagaac tccaagggcg agttctttag gaccgacccc     3540

aagaggcgcg agctgcctat cgacgccgat gccaatggcg cctacaacat cgccctgagg     3600

ggagagctga caatgagggc aatcgcagag aagttcgacc ctgatagcga gaagatggcc     3660

aagctggagc tgaagcacaa ggattggttc gagtttatgc agaccagagg cgac           3714


<210>  122
<211>  3846
<212>  DNA
<213>  Eubacterium eligens

<400>  122
atgaacggca ataggtccat cgtgtaccgc gagttcgtgg gcgtgatccc cgtggccaag       60

accctgagga atgagctgcg ccctgtgggc cacacacagg agcacatcat ccagaacggc      120

ctgatccagg aggacgagct gcggcaggag aagagcaccg agctgaagaa catcatggac      180

gattactata gagagtacat cgataagtct ctgagcggcg tgaccgacct ggacttcacc      240

ctgctgttcg agctgatgaa cctggtgcag agctccccct ccaaggacaa taagaaggcc      300

ctggagaagg agcagtctaa gatgagggag cagatctgca cccacctgca gtccgactct      360

aactacaaga atatctttaa cgccaagctg ctgaaggaga tcctgcctga tttcatcaag      420

aactacaatc agtatgacgt gaaggataag gccggcaagc tggagacact ggccctgttt      480

aatggcttca gcacatactt taccgacttc tttgagaaga ggaagaacgt gttcaccaag      540

gaggccgtga gcacatccat cgcctaccgc atcgtgcacg agaactccct gatcttcctg      600

gccaatatga cctcttataa gaagatcagc gagaaggccc tggatgagat cgaagtgatc      660

gagaagaaca atcaggacaa gatgggcgat tgggagctga atcagatctt taaccctgac      720

ttctacaata tggtgctgat ccagtccggc atcgacttct acaacgagat ctgcggcgtg      780

gtgaatgccc acatgaacct gtactgtcag cagaccaaga acaattataa cctgttcaag      840

atgcggaagc tgcacaagca gatcctggcc tacaccagca ccagcttcga ggtgcccaag      900

atgttcgagg acgatatgag cgtgtataac gccgtgaacg ccttcatcga cgagacagag      960

aagggcaaca tcatcggcaa gctgaaggat atcgtgaata agtacgacga gctggatgag     1020

aagagaatct atatcagcaa ggacttttac gagacactga gctgcttcat gtccggcaac     1080

tggaatctga tcacaggctg cgtggagaac ttctacgatg agaacatcca cgccaagggc     1140

aagtccaagg aggagaaggt gaagaaggcc gtgaaggagg acaagtacaa gtctatcaat     1200

gacgtgaacg atctggtgga gaagtatatc gatgagaagg agaggaatga gttcaagaac     1260

agcaatgcca agcagtacat ccgcgagatc tccaacatca tcaccgacac agagacagcc     1320

cacctggagt atgacgatca catctctctg atcgagagcg aggagaaggc cgacgagatg     1380

aagaagcggc tggatatgta tatgaacatg taccactggg ccaaggcctt tatcgtggac     1440

gaggtgctgg acagagatga gatgttctac agcgatatcg acgatatcta taatatcctg     1500

gagaacatcg tgccactgta taatcgggtg agaaactacg tgacccagaa gccctacaac     1560

tctaagaaga tcaagctgaa tttccagagc cctacactgg ccaatggctg gtcccagtct     1620

aaggagttcg acaacaatgc catcatcctg atcagagata acaagtacta tctggccatc     1680

ttcaatgcca agaacaagcc agacaagaag atcatccagg gcaactccga taagaagaac     1740

gacaacgatt acaagaagat ggtgtataac ctgctgccag gcgccaacaa gatgctgccc     1800

aaggtgtttc tgtctaagaa gggcatcgag acattcaagc cctccgacta tatcatctct     1860

ggctacaacg cccacaagca catcaagaca agcgagaatt ttgatatctc cttctgtcgg     1920

gacctgatcg attacttcaa gaacagcatc gagaagcacg ccgagtggag aaagtatgag     1980

ttcaagtttt ccgccaccga cagctactcc gatatctctg agttctatcg ggaggtggag     2040

atgcagggct acagaatcga ctggacatat atcagcgagg ccgacatcaa caagctggat     2100

gaggagggca agatctatct gtttcagatc tacaataagg atttcgccga gaacagcacc     2160

ggcaaggaga atctgcacac aatgtacttt aagaacatct tctccgagga gaatctgaag     2220

gacatcatca tcaagctgaa cggccaggcc gagctgtttt atcggagagc ctctgtgaag     2280

aatcccgtga agcacaagaa ggatagcgtg ctggtgaaca agacctacaa gaatcagctg     2340

gacaacggcg acgtggtgag aatccccatc cctgacgata tctataacga gatctacaag     2400

atgtataatg gctacatcaa ggagtccgac ctgtctgagg ccgccaagga gtacctggat     2460

aaggtggagg tgaggaccgc ccagaaggac atcgtgaagg attaccgcta tacagtggac     2520

aagtacttca tccacacacc tatcaccatc aactataagg tgaccgcccg caacaatgtg     2580

aatgatatgg tggtgaagta catcgcccag aacgacgata tccacgtgat cggcatcgac     2640

cggggcgaga gaaacctgat ctacatctcc gtgatcgatt ctcacggcaa catcgtgaag     2700

cagaaatcct acaacatcct gaacaactac gactacaaga agaagctggt ggagaaggag     2760

aaaacccggg agtacgccag aaagaactgg aagagcatcg gcaatatcaa ggagctgaag     2820

gagggctata tctccggcgt ggtgcacgag atcgccatgc tgatcgtgga gtacaacgcc     2880

atcatcgcca tggaggacct gaattatggc tttaagaggg gccgcttcaa ggtggagcgg     2940

caggtgtacc agaagtttga gagcatgctg atcaataagc tgaactattt cgccagcaag     3000

gagaagtccg tggacgagcc aggaggcctg ctgaagggct atcagctgac ctacgtgccc     3060

gataatatca agaacctggg caagcagtgc ggcgtgatct tttacgtgcc tgccgccttc     3120

accagcaaga tcgacccatc cacaggcttt atctctgcct tcaactttaa gtctatcagc     3180

acaaatgcct ctcggaagca gttctttatg cagtttgacg agatcagata ctgtgccgag     3240

aaggatatgt tcagctttgg cttcgactac aacaacttcg atacctacaa catcacaatg     3300

ggcaagacac agtggaccgt gtatacaaac ggcgagagac tgcagtctga gttcaacaat     3360

gccaggcgca ccggcaagac aaagagcatc aatctgacag agacaatcaa gctgctgctg     3420

gaggacaatg agatcaacta cgccgacggc cacgatatca ggatcgatat ggagaagatg     3480

gacgaggata agaagagcga gttctttgcc cagctgctga gcctgtataa gctgaccgtg     3540

cagatgcgca attcctatac agaggccgag gagcaggaga acggcatctc ttacgacaag     3600

atcatcagcc ctgtgatcaa tgatgagggc gagttctttg actccgataa ctataaggag     3660

tctgacgata aggagtgcaa gatgccaaag gacgccgatg ccaacggcgc ctactgtatc     3720

gccctgaagg gcctgtatga ggtgctgaag atcaagagcg agtggaccga ggacggcttt     3780

gataggaatt gcctgaagct gccacacgca gagtggctgg acttcatcca gaacaagcgg     3840

tacgag                                                                3846


<210>  123
<211>  4119
<212>  DNA
<213>  Moraxella bovoculi

<400>  123
atgctgttcc aggactttac ccacctgtat ccactgtcca agacagtgag atttgagctg       60

aagcccatcg ataggaccct ggagcacatc cacgccaaga acttcctgtc tcaggacgag      120

acaatggccg atatgcacca gaaggtgaaa gtgatcctgg acgattacca ccgcgacttc      180

atcgccgata tgatgggcga ggtgaagctg accaagctgg ccgagttcta tgacgtgtac      240

ctgaagtttc ggaagaaccc aaaggacgat gagctgcaga agcagctgaa ggatctgcag      300

gccgtgctga gaaaggagat cgtgaagccc atcggcaatg gcggcaagta taaggccggc      360

tacgacaggc tgttcggcgc caagctgttt aaggacggca aggagctggg cgatctggcc      420

aagttcgtga tcgcacagga gggagagagc tccccaaagc tggcccacct ggcccacttc      480

gagaagtttt ccacctattt cacaggcttt cacgataacc ggaagaatat gtattctgac      540

gaggataagc acaccgccat cgcctaccgc ctgatccacg agaacctgcc ccggtttatc      600

gacaatctgc agatcctgac cacaatcaag cagaagcact ctgccctgta cgatcagatc      660

atcaacgagc tgaccgccag cggcctggac gtgtctctgg ccagccacct ggatggctat      720

cacaagctgc tgacacagga gggcatcacc gcctacaata cactgctggg aggaatctcc      780

ggagaggcag gctctcctaa gatccagggc atcaacgagc tgatcaattc tcaccacaac      840

cagcactgcc acaagagcga gagaatcgcc aagctgaggc cactgcacaa gcagatcctg      900

tccgacggca tgagcgtgtc cttcctgccc tctaagtttg ccgacgatag cgagatgtgc      960

caggccgtga acgagttcta tcgccactac gccgacgtgt tcgccaaggt gcagagcctg     1020

ttcgacggct ttgacgatca ccagaaggat ggcatctacg tggagcacaa gaacctgaat     1080

gagctgtcca agcaggcctt cggcgacttt gcactgctgg gacgcgtgct ggacggatac     1140

tatgtggatg tggtgaatcc agagttcaac gagcggtttg ccaaggccaa gaccgacaat     1200

gccaaggcca agctgacaaa ggagaaggat aagttcatca agggcgtgca ctccctggcc     1260

tctctggagc aggccatcga gcactatacc gcaaggcacg acgatgagag cgtgcaggca     1320

ggcaagctgg gacagtactt caagcacggc ctggccggag tggacaaccc catccagaag     1380

atccacaaca atcacagcac catcaagggc tttctggaga gggagcgccc tgcaggagag     1440

agagccctgc caaagatcaa gtccggcaag aatcctgaga tgacacagct gaggcagctg     1500

aaggagctgc tggataacgc cctgaatgtg gcccacttcg ccaagctgct gaccacaaag     1560

accacactgg acaatcagga tggcaacttc tatggcgagt ttggcgtgct gtacgacgag     1620

ctggccaaga tccccaccct gtataacaag gtgagagatt acctgagcca gaagcctttc     1680

tccaccgaga agtacaagct gaactttggc aatccaacac tgctgaatgg ctgggacctg     1740

aacaaggaga aggataattt cggcgtgatc ctgcagaagg acggctgcta ctatctggcc     1800

ctgctggaca aggcccacaa gaaggtgttt gataacgccc ctaatacagg caagagcatc     1860

tatcagaaga tgatctataa gtacctggag gtgaggaagc agttccccaa ggtgttcttt     1920

tccaaggagg ccatcgccat caactaccac ccttctaagg agctggtgga gatcaaggac     1980

aagggccggc agagatccga cgatgagcgc ctgaagctgt atcggtttat cctggagtgt     2040

ctgaagatcc accctaagta cgataagaag ttcgagggcg ccatcggcga catccagctg     2100

tttaagaagg ataagaaggg cagagaggtg ccaatcagcg agaaggacct gttcgataag     2160

atcaacggca tcttttctag caagcctaag ctggagatgg aggacttctt tatcggcgag     2220

ttcaagaggt ataacccaag ccaggacctg gtggatcagt ataatatcta caagaagatc     2280

gactccaacg ataatcgcaa gaaggagaat ttctacaaca atcaccccaa gtttaagaag     2340

gatctggtgc ggtactatta cgagtctatg tgcaagcacg aggagtggga ggagagcttc     2400

gagttttcca agaagctgca ggacatcggc tgttacgtgg atgtgaacga gctgtttacc     2460

gagatcgaga cacggagact gaattataag atctccttct gcaacatcaa tgccgactac     2520

atcgatgagc tggtggagca gggccagctg tatctgttcc agatctacaa caaggacttt     2580

tccccaaagg cccacggcaa gcccaatctg cacaccctgt acttcaaggc cctgttttct     2640

gaggacaacc tggccgatcc tatctataag ctgaatggcg aggcccagat cttctacaga     2700

aaggcctccc tggacatgaa cgagacaaca atccacaggg ccggcgaggt gctggagaac     2760

aagaatcccg ataatcctaa gaagagacag ttcgtgtacg acatcatcaa ggataagagg     2820

tacacacagg acaagttcat gctgcacgtg ccaatcacca tgaactttgg cgtgcagggc     2880

atgacaatca aggagttcaa taagaaggtg aaccagtcta tccagcagta tgacgaggtg     2940

aacgtgatcg gcatcgatcg gggcgagaga cacctgctgt acctgaccgt gatcaatagc     3000

aagggcgaga tcctggagca gtgttccctg aacgacatca ccacagcctc tgccaatggc     3060

acacagatga ccacacctta ccacaagatc ctggataaga gggagatcga gcgcctgaac     3120

gcccgggtgg gatggggcga gatcgagaca atcaaggagc tgaagtctgg ctatctgagc     3180

cacgtggtgc accagatcag ccagctgatg ctgaagtaca acgccatcgt ggtgctggag     3240

gacctgaatt tcggctttaa gaggggccgc tttaaggtgg agaagcagat ctatcagaac     3300

ttcgagaatg ccctgatcaa gaagctgaac cacctggtgc tgaaggacaa ggccgacgat     3360

gagatcggct cttacaagaa tgccctgcag ctgaccaaca atttcacaga tctgaagagc     3420

atcggcaagc agaccggctt cctgttttat gtgcccgcct ggaacacctc taagatcgac     3480

cctgagacag gctttgtgga tctgctgaag ccaagatacg agaacatcgc ccagagccag     3540

gccttctttg gcaagttcga caagatctgc tataatgccg acaaggatta cttcgagttt     3600

cacatcgact acgccaagtt taccgataag gccaagaata gccgccagat ctggacaatc     3660

tgttcccacg gcgacaagcg gtacgtgtac gataagacag ccaaccagaa taagggcgcc     3720

gccaagggca tcaacgtgaa tgatgagctg aagtccctgt tcgcccgcca ccacatcaac     3780

gagaagcagc ccaacctggt catggacatc tgccagaaca atgataagga gtttcacaag     3840

tctctgatgt acctgctgaa aaccctgctg gccctgcggt acagcaacgc ctcctctgac     3900

gaggatttca tcctgtcccc cgtggcaaac gacgagggcg tgttctttaa tagcgccctg     3960

gccgacgata cacagcctca gaatgccgat gccaacggcg cctaccacat cgccctgaag     4020

ggcctgtggc tgctgaatga gctgaagaac tccgacgatc tgaacaaggt gaagctggcc     4080

atcgacaatc agacctggct gaatttcgcc cagaacagg                            4119


<210>  124
<211>  3969
<212>  DNA
<213>  Prevotella disiens

<400>  124
atggagaact atcaggagtt caccaacctg tttcagctga ataagacact gagattcgag       60

ctgaagccca tcggcaagac ctgcgagctg ctggaggagg gcaagatctt cgccagcggc      120

tcctttctgg agaaggacaa ggtgagggcc gataacgtga gctacgtgaa gaaggagatc      180

gacaagaagc acaagatctt tatcgaggag acactgagct ccttctctat cagcaacgat      240

ctgctgaagc agtactttga ctgctataat gagctgaagg ccttcaagaa ggactgtaag      300

agcgatgagg aggaggtgaa gaaaaccgcc ctgcgcaaca agtgtacctc catccagagg      360

gccatgcgcg aggccatctc tcaggccttt ctgaagagcc cccagaagaa gctgctggcc      420

atcaagaacc tgatcgagaa cgtgttcaag gccgacgaga atgtgcagca cttctccgag      480

tttaccagct atttctccgg ctttgagaca aacagagaga atttctactc tgacgaggag      540

aagtccacat ctatcgccta taggctggtg cacgataacc tgcctatctt catcaagaac      600

atctacatct tcgagaagct gaaggagcag ttcgacgcca agaccctgag cgagatcttc      660

gagaactaca agctgtatgt ggccggctct agcctggatg aggtgttctc cctggagtac      720

tttaacaata ccctgacaca gaagggcatc gacaactata atgccgtgat cggcaagatc      780

gtgaaggagg ataagcagga gatccagggc ctgaacgagc acatcaacct gtataatcag      840

aagcacaagg accggagact gcccttcttt atctccctga agaagcagat cctgtccgat      900

cgggaggccc tgtcttggct gcctgacatg ttcaagaatg attctgaagt gatcaaggcc      960

ctgaagggct tctacatcga ggacggcttt gagaacaatg tgctgacacc tctggccacc     1020

ctgctgtcct ctctggataa gtacaacctg aatggcatct ttatccgcaa caatgaggcc     1080

ctgagctccc tgtcccagaa cgtgtatcgg aatttttcta tcgacgaggc catcgatgcc     1140

aacgccgagc tgcagacctt caacaattac gagctgatcg ccaatgccct gcgcgccaag     1200

atcaagaagg agacaaagca gggccggaag tctttcgaga agtacgagga gtatatcgat     1260

aagaaggtga aggccatcga cagcctgtcc atccaggaga tcaacgagct ggtggagaat     1320

tacgtgagcg agtttaactc taatagcggc aacatgccaa gaaaggtgga ggactacttc     1380

agcctgatga ggaagggcga cttcggctcc aacgatctga tcgaaaatat caagaccaag     1440

ctgagcgccg cagagaagct gctgggcaca aagtaccagg agacagccaa ggacatcttc     1500

aagaaggatg agaactccaa gctgatcaag gagctgctgg acgccaccaa gcagttccag     1560

cactttatca agccactgct gggcacaggc gaggaggcag atcgggacct ggtgttctac     1620

ggcgattttc tgcccctgta tgagaagttt gaggagctga ccctgctgta taacaaggtg     1680

cggaatagac tgacacagaa gccctattcc aaggacaaga tccgcctgtg cttcaacaag     1740

cctaagctga tgacaggctg ggtggattcc aagaccgaga agtctgacaa cggcacacag     1800

tacggcggct atctgtttcg gaagaagaat gagatcggcg agtacgatta ttttctgggc     1860

atctctagca aggcccagct gttcagaaag aacgaggccg tgatcggcga ctacgagagg     1920

ctggattact atcagccaaa ggccaatacc atctacggct ctgcctatga gggcgagaac     1980

agctacaagg aggacaagaa gcggctgaac aaagtgatca tcgcctatat cgagcagatc     2040

aagcagacaa acatcaagaa gtctatcatc gagtccatct ctaagtatcc taatatcagc     2100

gacgatgaca aggtgacccc atcctctctg ctggagaaga tcaagaaggt gtctatcgac     2160

agctacaacg gcatcctgtc cttcaagtct tttcagagcg tgaacaagga agtgatcgat     2220

aacctgctga aaaccatcag ccccctgaag aacaaggccg agtttctgga cctgatcaat     2280

aaggattatc agatcttcac cgaggtgcag gccgtgatcg acgagatctg caagcagaaa     2340

accttcatct actttccaat ctccaacgtg gagctggaga aggagatggg cgataaggac     2400

aagcccctgt gcctgttcca gatcagcaat aaggatctgt ccttcgccaa gacctttagc     2460

gccaacctgc ggaagaagag aggcgccgag aatctgcaca caatgctgtt taaggccctg     2520

atggagggca accaggataa tctggacctg ggctctggcg ccatcttcta cagagccaag     2580

agcctggacg gcaacaagcc cacacaccct gccaatgagg ccatcaagtg taggaacgtg     2640

gccaataagg ataaggtgtc cctgttcacc tacgacatct ataagaacag gcgctacatg     2700

gagaataagt tcctgtttca cctgagcatc gtgcagaact ataaggccgc caatgactcc     2760

gcccagctga acagctccgc caccgagtat atcagaaagg ccgatgacct gcacatcatc     2820

ggcatcgata ggggcgagcg caatctgctg tactattccg tgatcgatat gaagggcaac     2880

atcgtggagc aggactctct gaatatcatc aggaacaatg acctggagac agattaccac     2940

gacctgctgg ataagaggga gaaggagcgc aaggccaacc ggcagaattg ggaggccgtg     3000

gagggcatca aggacctgaa gaagggctac ctgagccagg ccgtgcacca gatcgcccag     3060

ctgatgctga agtataacgc catcatcgcc ctggaggatc tgggccagat gtttgtgacc     3120

cgcggccaga agatcgagaa ggccgtgtac cagcagttcg agaagagcct ggtggataag     3180

ctgtcctacc tggtggacaa gaagcggcct tataatgagc tgggcggcat cctgaaggcc     3240

taccagctgg cctctagcat caccaagaac aattctgaca agcagaacgg cttcctgttt     3300

tatgtgccag cctggaatac aagcaagatc gatcccgtga ccggctttac agacctgctg     3360

cggcccaagg ccatgaccat caaggaggcc caggacttct ttggcgcctt cgataacatc     3420

tcttacaatg acaagggcta tttcgagttt gagacaaact acgacaagtt taagatcaga     3480

atgaagagcg cccagaccag gtggacaatc tgcaccttcg gcaatcggat caagagaaag     3540

aaggataaga actactggaa ttatgaggag gtggagctga ccgaggagtt caagaagctg     3600

tttaaggaca gcaacatcga ttacgagaac tgtaatctga aggaggagat ccagaacaag     3660

gacaatcgca agttctttga tgacctgatc aagctgctgc agctgacact gcagatgcgg     3720

aactccgatg acaagggcaa tgattatatc atctctcctg tggccaacgc cgagggccag     3780

ttctttgact cccgcaatgg cgataagaag ctgccactgg atgcagacgc aaacggagcc     3840

tacaatatcg cccgcaaggg cctgtggaac atccggcaga tcaagcagac caagaacgac     3900

aagaagctga atctgagcat ctcctctaca gagtggctgg atttcgtgcg ggagaagcct     3960

tacctgaag                                                             3969


<210>  125
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  125

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  126
<211>  1300
<212>  PRT
<213>  Francisella tularensis

<400>  126

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  127
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp. BV3L6

<400>  127

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  128
<211>  1233
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  128

Met Asp Tyr Gly Asn Gly Gln Phe Glu Arg Arg Ala Pro Leu Thr Lys 
1               5                   10                  15      


Thr Ile Thr Leu Arg Leu Lys Pro Ile Gly Glu Thr Arg Glu Thr Ile 
            20                  25                  30          


Arg Glu Gln Lys Leu Leu Glu Gln Asp Ala Ala Phe Arg Lys Leu Val 
        35                  40                  45              


Glu Thr Val Thr Pro Ile Val Asp Asp Cys Ile Arg Lys Ile Ala Asp 
    50                  55                  60                  


Asn Ala Leu Cys His Phe Gly Thr Glu Tyr Asp Phe Ser Cys Leu Gly 
65                  70                  75                  80  


Asn Ala Ile Ser Lys Asn Asp Ser Lys Ala Ile Lys Lys Glu Thr Glu 
                85                  90                  95      


Lys Val Glu Lys Leu Leu Ala Lys Val Leu Thr Glu Asn Leu Pro Asp 
            100                 105                 110         


Gly Leu Arg Lys Val Asn Asp Ile Asn Ser Ala Ala Phe Ile Gln Asp 
        115                 120                 125             


Thr Leu Thr Ser Phe Val Gln Asp Asp Ala Asp Lys Arg Val Leu Ile 
    130                 135                 140                 


Gln Glu Leu Lys Gly Lys Thr Val Leu Met Gln Arg Phe Leu Thr Thr 
145                 150                 155                 160 


Arg Ile Thr Ala Leu Thr Val Trp Leu Pro Asp Arg Val Phe Glu Asn 
                165                 170                 175     


Phe Asn Ile Phe Ile Glu Asn Ala Glu Lys Met Arg Ile Leu Leu Asp 
            180                 185                 190         


Ser Pro Leu Asn Glu Lys Ile Met Lys Phe Asp Pro Asp Ala Glu Gln 
        195                 200                 205             


Tyr Ala Ser Leu Glu Phe Tyr Gly Gln Cys Leu Ser Gln Lys Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Leu Ile Ile Ser Gly Ile Tyr Ala Asp Asp Glu Val 
225                 230                 235                 240 


Lys Asn Pro Gly Ile Asn Glu Ile Val Lys Glu Tyr Asn Gln Gln Ile 
                245                 250                 255     


Arg Gly Asp Lys Asp Glu Ser Pro Leu Pro Lys Leu Lys Lys Leu His 
            260                 265                 270         


Lys Gln Ile Leu Met Pro Val Glu Lys Ala Phe Phe Val Arg Val Leu 
        275                 280                 285             


Ser Asn Asp Ser Asp Ala Arg Ser Ile Leu Glu Lys Ile Leu Lys Asp 
    290                 295                 300                 


Thr Glu Met Leu Pro Ser Lys Ile Ile Glu Ala Met Lys Glu Ala Asp 
305                 310                 315                 320 


Ala Gly Asp Ile Ala Val Tyr Gly Ser Arg Leu His Glu Leu Ser His 
                325                 330                 335     


Val Ile Tyr Gly Asp His Gly Lys Leu Ser Gln Ile Ile Tyr Asp Lys 
            340                 345                 350         


Glu Ser Lys Arg Ile Ser Glu Leu Met Glu Thr Leu Ser Pro Lys Glu 
        355                 360                 365             


Arg Lys Glu Ser Lys Lys Arg Leu Glu Gly Leu Glu Glu His Ile Arg 
    370                 375                 380                 


Lys Ser Thr Tyr Thr Phe Asp Glu Leu Asn Arg Tyr Ala Glu Lys Asn 
385                 390                 395                 400 


Val Met Ala Ala Tyr Ile Ala Ala Val Glu Glu Ser Cys Ala Glu Ile 
                405                 410                 415     


Met Arg Lys Glu Lys Asp Leu Arg Thr Leu Leu Ser Lys Glu Asp Val 
            420                 425                 430         


Lys Ile Arg Gly Asn Arg His Asn Thr Leu Ile Val Lys Asn Tyr Phe 
        435                 440                 445             


Asn Ala Trp Thr Val Phe Arg Asn Leu Ile Arg Ile Leu Arg Arg Lys 
    450                 455                 460                 


Ser Glu Ala Glu Ile Asp Ser Asp Phe Tyr Asp Val Leu Asp Asp Ser 
465                 470                 475                 480 


Val Glu Val Leu Ser Leu Thr Tyr Lys Gly Glu Asn Leu Cys Arg Ser 
                485                 490                 495     


Tyr Ile Thr Lys Lys Ile Gly Ser Asp Leu Lys Pro Glu Ile Ala Thr 
            500                 505                 510         


Tyr Gly Ser Ala Leu Arg Pro Asn Ser Arg Trp Trp Ser Pro Gly Glu 
        515                 520                 525             


Lys Phe Asn Val Lys Phe His Thr Ile Val Arg Arg Asp Gly Arg Leu 
    530                 535                 540                 


Tyr Tyr Phe Ile Leu Pro Lys Gly Ala Lys Pro Val Glu Leu Glu Asp 
545                 550                 555                 560 


Met Asp Gly Asp Ile Glu Cys Leu Gln Met Arg Lys Ile Pro Asn Pro 
                565                 570                 575     


Thr Ile Phe Leu Pro Lys Leu Val Phe Lys Asp Pro Glu Ala Phe Phe 
            580                 585                 590         


Arg Asp Asn Pro Glu Ala Asp Glu Phe Val Phe Leu Ser Gly Met Lys 
        595                 600                 605             


Ala Pro Val Thr Ile Thr Arg Glu Thr Tyr Glu Ala Tyr Arg Tyr Lys 
    610                 615                 620                 


Leu Tyr Thr Val Gly Lys Leu Arg Asp Gly Glu Val Ser Glu Glu Glu 
625                 630                 635                 640 


Tyr Lys Arg Ala Leu Leu Gln Val Leu Thr Ala Tyr Lys Glu Phe Leu 
                645                 650                 655     


Glu Asn Arg Met Ile Tyr Ala Asp Leu Asn Phe Gly Phe Lys Asp Leu 
            660                 665                 670         


Glu Glu Tyr Lys Asp Ser Ser Glu Phe Ile Lys Gln Val Glu Thr His 
        675                 680                 685             


Asn Thr Phe Met Cys Trp Ala Lys Val Ser Ser Ser Gln Leu Asp Asp 
    690                 695                 700                 


Leu Val Lys Ser Gly Asn Gly Leu Leu Phe Glu Ile Trp Ser Glu Arg 
705                 710                 715                 720 


Leu Glu Ser Tyr Tyr Lys Tyr Gly Asn Glu Lys Val Leu Arg Gly Tyr 
                725                 730                 735     


Glu Gly Val Leu Leu Ser Ile Leu Lys Asp Glu Asn Leu Val Ser Met 
            740                 745                 750         


Arg Thr Leu Leu Asn Ser Arg Pro Met Leu Val Tyr Arg Pro Lys Glu 
        755                 760                 765             


Ser Ser Lys Pro Met Val Val His Arg Asp Gly Ser Arg Val Val Asp 
    770                 775                 780                 


Arg Phe Asp Lys Asp Gly Lys Tyr Ile Pro Pro Glu Val His Asp Glu 
785                 790                 795                 800 


Leu Tyr Arg Phe Phe Asn Asn Leu Leu Ile Lys Glu Lys Leu Gly Glu 
                805                 810                 815     


Lys Ala Arg Lys Ile Leu Asp Asn Lys Lys Val Lys Val Lys Val Leu 
            820                 825                 830         


Glu Ser Glu Arg Val Lys Trp Ser Lys Phe Tyr Asp Glu Gln Phe Ala 
        835                 840                 845             


Val Thr Phe Ser Val Lys Lys Asn Ala Asp Cys Leu Asp Thr Thr Lys 
    850                 855                 860                 


Asp Leu Asn Ala Glu Val Met Glu Gln Tyr Ser Glu Ser Asn Arg Leu 
865                 870                 875                 880 


Ile Leu Ile Arg Asn Thr Thr Asp Ile Leu Tyr Tyr Leu Val Leu Asp 
                885                 890                 895     


Lys Asn Gly Lys Val Leu Lys Gln Arg Ser Leu Asn Ile Ile Asn Asp 
            900                 905                 910         


Gly Ala Arg Asp Val Asp Trp Lys Glu Arg Phe Arg Gln Val Thr Lys 
        915                 920                 925             


Asp Arg Asn Glu Gly Tyr Asn Glu Trp Asp Tyr Ser Arg Thr Ser Asn 
    930                 935                 940                 


Asp Leu Lys Glu Val Tyr Leu Asn Tyr Ala Leu Lys Glu Ile Ala Glu 
945                 950                 955                 960 


Ala Val Ile Glu Tyr Asn Ala Ile Leu Ile Ile Glu Lys Met Ser Asn 
                965                 970                 975     


Ala Phe Lys Asp Lys Tyr Ser Phe Leu Asp Asp Val Thr Phe Lys Gly 
            980                 985                 990         


Phe Glu Thr Lys Leu Leu Ala Lys  Leu Ser Asp Leu His  Phe Arg Gly 
        995                 1000                 1005             


Ile Lys  Asp Gly Glu Pro Cys  Ser Phe Thr Asn Pro  Leu Gln Leu 
    1010                 1015                 1020             


Cys Gln  Asn Asp Ser Asn Lys  Ile Leu Gln Asp Gly  Val Ile Phe 
    1025                 1030                 1035             


Met Val  Pro Asn Ser Met Thr  Arg Ser Leu Asp Pro  Asp Thr Gly 
    1040                 1045                 1050             


Phe Ile  Phe Ala Ile Asn Asp  His Asn Ile Arg Thr  Lys Lys Ala 
    1055                 1060                 1065             


Lys Leu  Asn Phe Leu Ser Lys  Phe Asp Gln Leu Lys  Val Ser Ser 
    1070                 1075                 1080             


Glu Gly  Cys Leu Ile Met Lys  Tyr Ser Gly Asp Ser  Leu Pro Thr 
    1085                 1090                 1095             


His Asn  Thr Asp Asn Arg Val  Trp Asn Cys Cys Cys  Asn His Pro 
    1100                 1105                 1110             


Ile Thr  Asn Tyr Asp Arg Glu  Thr Lys Lys Val Glu  Phe Ile Glu 
    1115                 1120                 1125             


Glu Pro  Val Glu Glu Leu Ser  Arg Val Leu Glu Glu  Asn Gly Ile 
    1130                 1135                 1140             


Glu Thr  Asp Thr Glu Leu Asn  Lys Leu Asn Glu Arg  Glu Asn Val 
    1145                 1150                 1155             


Pro Gly  Lys Val Val Asp Ala  Ile Tyr Ser Leu Val  Leu Asn Tyr 
    1160                 1165                 1170             


Leu Arg  Gly Thr Val Ser Gly  Val Ala Gly Gln Arg  Ala Val Tyr 
    1175                 1180                 1185             


Tyr Ser  Pro Val Thr Gly Lys  Lys Tyr Asp Ile Ser  Phe Ile Gln 
    1190                 1195                 1200             


Ala Met  Asn Leu Asn Arg Lys  Cys Asp Tyr Tyr Arg  Ile Gly Ser 
    1205                 1210                 1215             


Lys Glu  Arg Gly Glu Trp Thr  Asp Phe Val Ala Gln  Leu Ile Asn 
    1220                 1225                 1230             


<210>  129
<211>  1246
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  129

Met Leu Lys Asn Val Gly Ile Asp Arg Leu Asp Val Glu Lys Gly Arg 
1               5                   10                  15      


Lys Asn Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Arg Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His 
    1235                 1240                 1245     


<210>  130
<211>  1228
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  130

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  131
<211>  1300
<212>  PRT
<213>  Francisella tularensis

<400>  131

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  132
<211>  1477
<212>  PRT
<213>  Peregrinibacteria

<400>  132

Met Ser Asn Phe Phe Lys Asn Phe Thr Asn Leu Tyr Glu Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Asp Thr Leu Thr Asn Met 
            20                  25                  30          


Lys Asp His Leu Glu Tyr Asp Glu Lys Leu Gln Thr Phe Leu Lys Asp 
        35                  40                  45              


Gln Asn Ile Asp Asp Ala Tyr Gln Ala Leu Lys Pro Gln Phe Asp Glu 
    50                  55                  60                  


Ile His Glu Glu Phe Ile Thr Asp Ser Leu Glu Ser Lys Lys Ala Lys 
65                  70                  75                  80  


Glu Ile Asp Phe Ser Glu Tyr Leu Asp Leu Phe Gln Glu Lys Lys Glu 
                85                  90                  95      


Leu Asn Asp Ser Glu Lys Lys Leu Arg Asn Lys Ile Gly Glu Thr Phe 
            100                 105                 110         


Asn Lys Ala Gly Glu Lys Trp Lys Lys Glu Lys Tyr Pro Gln Tyr Glu 
        115                 120                 125             


Trp Lys Lys Gly Ser Lys Ile Ala Asn Gly Ala Asp Ile Leu Ser Cys 
    130                 135                 140                 


Gln Asp Met Leu Gln Phe Ile Lys Tyr Lys Asn Pro Glu Asp Glu Lys 
145                 150                 155                 160 


Ile Lys Asn Tyr Ile Asp Asp Thr Leu Lys Gly Phe Phe Thr Tyr Phe 
                165                 170                 175     


Gly Gly Phe Asn Gln Asn Arg Ala Asn Tyr Tyr Glu Thr Lys Lys Glu 
            180                 185                 190         


Ala Ser Thr Ala Val Ala Thr Arg Ile Val His Glu Asn Leu Pro Lys 
        195                 200                 205             


Phe Cys Asp Asn Val Ile Gln Phe Lys His Ile Ile Lys Arg Lys Lys 
    210                 215                 220                 


Asp Gly Thr Val Glu Lys Thr Glu Arg Lys Thr Glu Tyr Leu Asn Ala 
225                 230                 235                 240 


Tyr Gln Tyr Leu Lys Asn Asn Asn Lys Ile Thr Gln Ile Lys Asp Ala 
                245                 250                 255     


Glu Thr Glu Lys Met Ile Glu Ser Thr Pro Ile Ala Glu Lys Ile Phe 
            260                 265                 270         


Asp Val Tyr Tyr Phe Ser Ser Cys Leu Ser Gln Lys Gln Ile Glu Glu 
        275                 280                 285             


Tyr Asn Arg Ile Ile Gly His Tyr Asn Leu Leu Ile Asn Leu Tyr Asn 
    290                 295                 300                 


Gln Ala Lys Arg Ser Glu Gly Lys His Leu Ser Ala Asn Glu Lys Lys 
305                 310                 315                 320 


Tyr Lys Asp Leu Pro Lys Phe Lys Thr Leu Tyr Lys Gln Ile Gly Cys 
                325                 330                 335     


Gly Lys Lys Lys Asp Leu Phe Tyr Thr Ile Lys Cys Asp Thr Glu Glu 
            340                 345                 350         


Glu Ala Asn Lys Ser Arg Asn Glu Gly Lys Glu Ser His Ser Val Glu 
        355                 360                 365             


Glu Ile Ile Asn Lys Ala Gln Glu Ala Ile Asn Lys Tyr Phe Lys Ser 
    370                 375                 380                 


Asn Asn Asp Cys Glu Asn Ile Asn Thr Val Pro Asp Phe Ile Asn Tyr 
385                 390                 395                 400 


Ile Leu Thr Lys Glu Asn Tyr Glu Gly Val Tyr Trp Ser Lys Ala Ala 
                405                 410                 415     


Met Asn Thr Ile Ser Asp Lys Tyr Phe Ala Asn Tyr His Asp Leu Gln 
            420                 425                 430         


Asp Arg Leu Lys Glu Ala Lys Val Phe Gln Lys Ala Asp Lys Lys Ser 
        435                 440                 445             


Glu Asp Asp Ile Lys Ile Pro Glu Ala Ile Glu Leu Ser Gly Leu Phe 
    450                 455                 460                 


Gly Val Leu Asp Ser Leu Ala Asp Trp Gln Thr Thr Leu Phe Lys Ser 
465                 470                 475                 480 


Ser Ile Leu Ser Asn Glu Asp Lys Leu Lys Ile Ile Thr Asp Ser Gln 
                485                 490                 495     


Thr Pro Ser Glu Ala Leu Leu Lys Met Ile Phe Asn Asp Ile Glu Lys 
            500                 505                 510         


Asn Met Glu Ser Phe Leu Lys Glu Thr Asn Asp Ile Ile Thr Leu Lys 
        515                 520                 525             


Lys Tyr Lys Gly Asn Lys Glu Gly Thr Glu Lys Ile Lys Gln Trp Phe 
    530                 535                 540                 


Asp Tyr Thr Leu Ala Ile Asn Arg Met Leu Lys Tyr Phe Leu Val Lys 
545                 550                 555                 560 


Glu Asn Lys Ile Lys Gly Asn Ser Leu Asp Thr Asn Ile Ser Glu Ala 
                565                 570                 575     


Leu Lys Thr Leu Ile Tyr Ser Asp Asp Ala Glu Trp Phe Lys Trp Tyr 
            580                 585                 590         


Asp Ala Leu Arg Asn Tyr Leu Thr Gln Lys Pro Gln Asp Glu Ala Lys 
        595                 600                 605             


Glu Asn Lys Leu Lys Leu Asn Phe Asp Asn Pro Ser Leu Ala Gly Gly 
    610                 615                 620                 


Trp Asp Val Asn Lys Glu Cys Ser Asn Phe Cys Val Ile Leu Lys Asp 
625                 630                 635                 640 


Lys Asn Glu Lys Lys Tyr Leu Ala Ile Met Lys Lys Gly Glu Asn Thr 
                645                 650                 655     


Leu Phe Gln Lys Glu Trp Thr Glu Gly Arg Gly Lys Asn Leu Thr Lys 
            660                 665                 670         


Lys Ser Asn Pro Leu Phe Glu Ile Asn Asn Cys Glu Ile Leu Ser Lys 
        675                 680                 685             


Met Glu Tyr Asp Phe Trp Ala Asp Val Ser Lys Met Ile Pro Lys Cys 
    690                 695                 700                 


Ser Thr Gln Leu Lys Ala Val Val Asn His Phe Lys Gln Ser Asp Asn 
705                 710                 715                 720 


Glu Phe Ile Phe Pro Ile Gly Tyr Lys Val Thr Ser Gly Glu Lys Phe 
                725                 730                 735     


Arg Glu Glu Cys Lys Ile Ser Lys Gln Asp Phe Glu Leu Asn Asn Lys 
            740                 745                 750         


Val Phe Asn Lys Asn Glu Leu Ser Val Thr Ala Met Arg Tyr Asp Leu 
        755                 760                 765             


Ser Ser Thr Gln Glu Lys Gln Tyr Ile Lys Ala Phe Gln Lys Glu Tyr 
    770                 775                 780                 


Trp Glu Leu Leu Phe Lys Gln Glu Lys Arg Asp Thr Lys Leu Thr Asn 
785                 790                 795                 800 


Asn Glu Ile Phe Asn Glu Trp Ile Asn Phe Cys Asn Lys Lys Tyr Ser 
                805                 810                 815     


Glu Leu Leu Ser Trp Glu Arg Lys Tyr Lys Asp Ala Leu Thr Asn Trp 
            820                 825                 830         


Ile Asn Phe Cys Lys Tyr Phe Leu Ser Lys Tyr Pro Lys Thr Thr Leu 
        835                 840                 845             


Phe Asn Tyr Ser Phe Lys Glu Ser Glu Asn Tyr Asn Ser Leu Asp Glu 
    850                 855                 860                 


Phe Tyr Arg Asp Val Asp Ile Cys Ser Tyr Lys Leu Asn Ile Asn Thr 
865                 870                 875                 880 


Thr Ile Asn Lys Ser Ile Leu Asp Arg Leu Val Glu Glu Gly Lys Leu 
                885                 890                 895     


Tyr Leu Phe Glu Ile Lys Asn Gln Asp Ser Asn Asp Gly Lys Ser Ile 
            900                 905                 910         


Gly His Lys Asn Asn Leu His Thr Ile Tyr Trp Asn Ala Ile Phe Glu 
        915                 920                 925             


Asn Phe Asp Asn Arg Pro Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr 
    930                 935                 940                 


Arg Lys Ala Ile Ser Lys Asp Lys Leu Gly Ile Val Lys Gly Lys Lys 
945                 950                 955                 960 


Thr Lys Asn Gly Thr Glu Ile Ile Lys Asn Tyr Arg Phe Ser Lys Glu 
                965                 970                 975     


Lys Phe Ile Leu His Val Pro Ile Thr Leu Asn Phe Cys Ser Asn Asn 
            980                 985                 990         


Glu Tyr Val Asn Asp Ile Val Asn  Thr Lys Phe Tyr Asn  Phe Ser Asn 
        995                 1000                 1005             


Leu His  Phe Leu Gly Ile Asp  Arg Gly Glu Lys His  Leu Ala Tyr 
    1010                 1015                 1020             


Tyr Ser  Leu Val Asn Lys Asn  Gly Glu Ile Val Asp  Gln Gly Thr 
    1025                 1030                 1035             


Leu Asn  Leu Pro Phe Thr Asp  Lys Asp Gly Asn Gln  Arg Ser Ile 
    1040                 1045                 1050             


Lys Lys  Glu Lys Tyr Phe Tyr  Asn Lys Gln Glu Asp  Lys Trp Glu 
    1055                 1060                 1065             


Ala Lys  Glu Val Asp Cys Trp  Asn Tyr Asn Asp Leu  Leu Asp Ala 
    1070                 1075                 1080             


Met Ala  Ser Asn Arg Asp Met  Ala Arg Lys Asn Trp  Gln Arg Ile 
    1085                 1090                 1095             


Gly Thr  Ile Lys Glu Ala Lys  Asn Gly Tyr Val Ser  Leu Val Ile 
    1100                 1105                 1110             


Arg Lys  Ile Ala Asp Leu Ala  Val Asn Asn Glu Arg  Pro Ala Phe 
    1115                 1120                 1125             


Ile Val  Leu Glu Asp Leu Asn  Thr Gly Phe Lys Arg  Ser Arg Gln 
    1130                 1135                 1140             


Lys Ile  Asp Lys Ser Val Tyr  Gln Lys Phe Glu Leu  Ala Leu Ala 
    1145                 1150                 1155             


Lys Lys  Leu Asn Phe Leu Val  Asp Lys Asn Ala Lys  Arg Asp Glu 
    1160                 1165                 1170             


Ile Gly  Ser Pro Thr Lys Ala  Leu Gln Leu Thr Pro  Pro Val Asn 
    1175                 1180                 1185             


Asn Tyr  Gly Asp Ile Glu Asn  Lys Lys Gln Ala Gly  Ile Met Leu 
    1190                 1195                 1200             


Tyr Thr  Arg Ala Asn Tyr Thr  Ser Gln Thr Asp Pro  Ala Thr Gly 
    1205                 1210                 1215             


Trp Arg  Lys Thr Ile Tyr Leu  Lys Ala Gly Pro Glu  Glu Thr Thr 
    1220                 1225                 1230             


Tyr Lys  Lys Asp Gly Lys Ile  Lys Asn Lys Ser Val  Lys Asp Gln 
    1235                 1240                 1245             


Ile Ile  Glu Thr Phe Thr Asp  Ile Gly Phe Asp Gly  Lys Asp Tyr 
    1250                 1255                 1260             


Tyr Phe  Glu Tyr Asp Lys Gly  Glu Phe Val Asp Glu  Lys Thr Gly 
    1265                 1270                 1275             


Glu Ile  Lys Pro Lys Lys Trp  Arg Leu Tyr Ser Gly  Glu Asn Gly 
    1280                 1285                 1290             


Lys Ser  Leu Asp Arg Phe Arg  Gly Glu Arg Glu Lys  Asp Lys Tyr 
    1295                 1300                 1305             


Glu Trp  Lys Ile Asp Lys Ile  Asp Ile Val Lys Ile  Leu Asp Asp 
    1310                 1315                 1320             


Leu Phe  Val Asn Phe Asp Lys  Asn Ile Ser Leu Leu  Lys Gln Leu 
    1325                 1330                 1335             


Lys Glu  Gly Val Glu Leu Thr  Arg Asn Asn Glu His  Gly Thr Gly 
    1340                 1345                 1350             


Glu Ser  Leu Arg Phe Ala Ile  Asn Leu Ile Gln Gln  Ile Arg Asn 
    1355                 1360                 1365             


Thr Gly  Asn Asn Glu Arg Asp  Asn Asp Phe Ile Leu  Ser Pro Val 
    1370                 1375                 1380             


Arg Asp  Glu Asn Gly Lys His  Phe Asp Ser Arg Glu  Tyr Trp Asp 
    1385                 1390                 1395             


Lys Glu  Thr Lys Gly Glu Lys  Ile Ser Met Pro Ser  Ser Gly Asp 
    1400                 1405                 1410             


Ala Asn  Gly Ala Phe Asn Ile  Ala Arg Lys Gly Ile  Ile Met Asn 
    1415                 1420                 1425             


Ala His  Ile Leu Ala Asn Ser  Asp Ser Lys Asp Leu  Ser Leu Phe 
    1430                 1435                 1440             


Val Ser  Asp Glu Glu Trp Asp  Leu His Leu Asn Asn  Lys Thr Glu 
    1445                 1450                 1455             


Trp Lys  Lys Gln Leu Asn Ile  Phe Ser Ser Arg Lys  Ala Met Ala 
    1460                 1465                 1470             


Lys Arg  Lys Lys 
    1475         


<210>  133
<211>  1352
<212>  PRT
<213>  Parcubacteria

<400>  133

Met Glu Asn Ile Phe Asp Gln Phe Ile Gly Lys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Glu Asp Phe Leu 
            20                  25                  30          


Lys Ile Asn Lys Val Phe Glu Lys Asp Gln Thr Ile Asp Asp Ser Tyr 
        35                  40                  45              


Asn Gln Ala Lys Phe Tyr Phe Asp Ser Leu His Gln Lys Phe Ile Asp 
    50                  55                  60                  


Ala Ala Leu Ala Ser Asp Lys Thr Ser Glu Leu Ser Phe Gln Asn Phe 
65                  70                  75                  80  


Ala Asp Val Leu Glu Lys Gln Asn Lys Ile Ile Leu Asp Lys Lys Arg 
                85                  90                  95      


Glu Met Gly Ala Leu Arg Lys Arg Asp Lys Asn Ala Val Gly Ile Asp 
            100                 105                 110         


Arg Leu Gln Lys Glu Ile Asn Asp Ala Glu Asp Ile Ile Gln Lys Glu 
        115                 120                 125             


Lys Glu Lys Ile Tyr Lys Asp Val Arg Thr Leu Phe Asp Asn Glu Ala 
    130                 135                 140                 


Glu Ser Trp Lys Thr Tyr Tyr Gln Glu Arg Glu Val Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Thr Phe Ser Lys Ala Asp Leu Lys Gln Lys Gly Ala Asp Phe Leu 
                165                 170                 175     


Thr Ala Ala Gly Ile Leu Lys Val Leu Lys Tyr Glu Phe Pro Glu Glu 
            180                 185                 190         


Lys Glu Lys Glu Phe Gln Ala Lys Asn Gln Pro Ser Leu Phe Val Glu 
        195                 200                 205             


Glu Lys Glu Asn Pro Gly Gln Lys Arg Tyr Ile Phe Asp Ser Phe Asp 
    210                 215                 220                 


Lys Phe Ala Gly Tyr Leu Thr Lys Phe Gln Gln Thr Lys Lys Asn Leu 
225                 230                 235                 240 


Tyr Ala Ala Asp Gly Thr Ser Thr Ala Val Ala Thr Arg Ile Ala Asp 
                245                 250                 255     


Asn Phe Ile Ile Phe His Gln Asn Thr Lys Val Phe Arg Asp Lys Tyr 
            260                 265                 270         


Lys Asn Asn His Thr Asp Leu Gly Phe Asp Glu Glu Asn Ile Phe Glu 
        275                 280                 285             


Ile Glu Arg Tyr Lys Asn Cys Leu Leu Gln Arg Glu Ile Glu His Ile 
    290                 295                 300                 


Lys Asn Glu Asn Ser Tyr Asn Lys Ile Ile Gly Arg Ile Asn Lys Lys 
305                 310                 315                 320 


Ile Lys Glu Tyr Arg Asp Gln Lys Ala Lys Asp Thr Lys Leu Thr Lys 
                325                 330                 335     


Ser Asp Phe Pro Phe Phe Lys Asn Leu Asp Lys Gln Ile Leu Gly Glu 
            340                 345                 350         


Val Glu Lys Glu Lys Gln Leu Ile Glu Lys Thr Arg Glu Lys Thr Glu 
        355                 360                 365             


Glu Asp Val Leu Ile Glu Arg Phe Lys Glu Phe Ile Glu Asn Asn Glu 
    370                 375                 380                 


Glu Arg Phe Thr Ala Ala Lys Lys Leu Met Asn Ala Phe Cys Asn Gly 
385                 390                 395                 400 


Glu Phe Glu Ser Glu Tyr Glu Gly Ile Tyr Leu Lys Asn Lys Ala Ile 
                405                 410                 415     


Asn Thr Ile Ser Arg Arg Trp Phe Val Ser Asp Arg Asp Phe Glu Leu 
            420                 425                 430         


Lys Leu Pro Gln Gln Lys Ser Lys Asn Lys Ser Glu Lys Asn Glu Pro 
        435                 440                 445             


Lys Val Lys Lys Phe Ile Ser Ile Ala Glu Ile Lys Asn Ala Val Glu 
    450                 455                 460                 


Glu Leu Asp Gly Asp Ile Phe Lys Ala Val Phe Tyr Asp Lys Lys Ile 
465                 470                 475                 480 


Ile Ala Gln Gly Gly Ser Lys Leu Glu Gln Phe Leu Val Ile Trp Lys 
                485                 490                 495     


Tyr Glu Phe Glu Tyr Leu Phe Arg Asp Ile Glu Arg Glu Asn Gly Glu 
            500                 505                 510         


Lys Leu Leu Gly Tyr Asp Ser Cys Leu Lys Ile Ala Lys Gln Leu Gly 
        515                 520                 525             


Ile Phe Pro Gln Glu Lys Glu Ala Arg Glu Lys Ala Thr Ala Val Ile 
    530                 535                 540                 


Lys Asn Tyr Ala Asp Ala Gly Leu Gly Ile Phe Gln Met Met Lys Tyr 
545                 550                 555                 560 


Phe Ser Leu Asp Asp Lys Asp Arg Lys Asn Thr Pro Gly Gln Leu Ser 
                565                 570                 575     


Thr Asn Phe Tyr Ala Glu Tyr Asp Gly Tyr Tyr Lys Asp Phe Glu Phe 
            580                 585                 590         


Ile Lys Tyr Tyr Asn Glu Phe Arg Asn Phe Ile Thr Lys Lys Pro Phe 
        595                 600                 605             


Asp Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly Ala Leu Leu Lys 
    610                 615                 620                 


Gly Trp Asp Glu Asn Lys Glu Tyr Asp Phe Met Gly Val Ile Leu Lys 
625                 630                 635                 640 


Lys Glu Gly Arg Leu Tyr Leu Gly Ile Met His Lys Asn His Arg Lys 
                645                 650                 655     


Leu Phe Gln Ser Met Gly Asn Ala Lys Gly Asp Asn Ala Asn Arg Tyr 
            660                 665                 670         


Gln Lys Met Ile Tyr Lys Gln Ile Ala Asp Ala Ser Lys Asp Val Pro 
        675                 680                 685             


Arg Leu Leu Leu Thr Ser Lys Lys Ala Met Glu Lys Phe Lys Pro Ser 
    690                 695                 700                 


Gln Glu Ile Leu Arg Ile Lys Lys Glu Lys Thr Phe Lys Arg Glu Ser 
705                 710                 715                 720 


Lys Asn Phe Ser Leu Arg Asp Leu His Ala Leu Ile Glu Tyr Tyr Arg 
                725                 730                 735     


Asn Cys Ile Pro Gln Tyr Ser Asn Trp Ser Phe Tyr Asp Phe Gln Phe 
            740                 745                 750         


Gln Asp Thr Gly Lys Tyr Gln Asn Ile Lys Glu Phe Thr Asp Asp Val 
        755                 760                 765             


Gln Lys Tyr Gly Tyr Lys Ile Ser Phe Arg Asp Ile Asp Asp Glu Tyr 
    770                 775                 780                 


Ile Asn Gln Ala Leu Asn Glu Gly Lys Met Tyr Leu Phe Glu Val Val 
785                 790                 795                 800 


Asn Lys Asp Ile Tyr Asn Thr Lys Asn Gly Ser Lys Asn Leu His Thr 
                805                 810                 815     


Leu Tyr Phe Glu His Ile Leu Ser Ala Glu Asn Leu Asn Asp Pro Val 
            820                 825                 830         


Phe Lys Leu Ser Gly Met Ala Glu Ile Phe Gln Arg Gln Pro Ser Val 
        835                 840                 845             


Asn Glu Arg Glu Lys Ile Thr Thr Gln Lys Asn Gln Cys Ile Leu Asp 
    850                 855                 860                 


Lys Gly Asp Arg Ala Tyr Lys Tyr Arg Arg Tyr Thr Glu Lys Lys Ile 
865                 870                 875                 880 


Met Phe His Met Ser Leu Val Leu Asn Thr Gly Lys Gly Glu Ile Lys 
                885                 890                 895     


Gln Val Gln Phe Asn Lys Ile Ile Asn Gln Arg Ile Ser Ser Ser Asp 
            900                 905                 910         


Asn Glu Met Arg Val Asn Val Ile Gly Ile Asp Arg Gly Glu Lys Asn 
        915                 920                 925             


Leu Leu Tyr Tyr Ser Val Val Lys Gln Asn Gly Glu Ile Ile Glu Gln 
    930                 935                 940                 


Ala Ser Leu Asn Glu Ile Asn Gly Val Asn Tyr Arg Asp Lys Leu Ile 
945                 950                 955                 960 


Glu Arg Glu Lys Glu Arg Leu Lys Asn Arg Gln Ser Trp Lys Pro Val 
                965                 970                 975     


Val Lys Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser His Val Ile His 
            980                 985                 990         


Lys Ile Cys Gln Leu Ile Glu Lys  Tyr Ser Ala Ile Val  Val Leu Glu 
        995                 1000                 1005             


Asp Leu  Asn Met Arg Phe Lys  Gln Ile Arg Gly Gly  Ile Glu Arg 
    1010                 1015                 1020             


Ser Val  Tyr Gln Gln Phe Glu  Lys Ala Leu Ile Asp  Lys Leu Gly 
    1025                 1030                 1035             


Tyr Leu  Val Phe Lys Asp Asn  Arg Asp Leu Arg Ala  Pro Gly Gly 
    1040                 1045                 1050             


Val Leu  Asn Gly Tyr Gln Leu  Ser Ala Pro Phe Val  Ser Phe Glu 
    1055                 1060                 1065             


Lys Met  Arg Lys Gln Thr Gly  Ile Leu Phe Tyr Thr  Gln Ala Glu 
    1070                 1075                 1080             


Tyr Thr  Ser Lys Thr Asp Pro  Ile Thr Gly Phe Arg  Lys Asn Val 
    1085                 1090                 1095             


Tyr Ile  Ser Asn Ser Ala Ser  Leu Asp Lys Ile Lys  Glu Ala Val 
    1100                 1105                 1110             


Lys Lys  Phe Asp Ala Ile Gly  Trp Asp Gly Lys Glu  Gln Ser Tyr 
    1115                 1120                 1125             


Phe Phe  Lys Tyr Asn Pro Tyr  Asn Leu Ala Asp Glu  Lys Tyr Lys 
    1130                 1135                 1140             


Asn Ser  Thr Val Ser Lys Glu  Trp Ala Ile Phe Ala  Ser Ala Pro 
    1145                 1150                 1155             


Arg Ile  Arg Arg Gln Lys Gly  Glu Asp Gly Tyr Trp  Lys Tyr Asp 
    1160                 1165                 1170             


Arg Val  Lys Val Asn Glu Glu  Phe Glu Lys Leu Leu  Lys Val Trp 
    1175                 1180                 1185             


Asn Phe  Val Asn Pro Lys Ala  Thr Asp Ile Lys Gln  Glu Ile Ile 
    1190                 1195                 1200             


Lys Lys  Glu Lys Ala Gly Asp  Leu Gln Gly Glu Lys  Glu Leu Asp 
    1205                 1210                 1215             


Gly Arg  Leu Arg Asn Phe Trp  His Ser Phe Ile Tyr  Leu Phe Asn 
    1220                 1225                 1230             


Leu Val  Leu Glu Leu Arg Asn  Ser Phe Ser Leu Gln  Ile Lys Ile 
    1235                 1240                 1245             


Lys Ala  Gly Glu Val Ile Ala  Val Asp Glu Gly Val  Asp Phe Ile 
    1250                 1255                 1260             


Ala Ser  Pro Val Lys Pro Phe  Phe Thr Thr Pro Asn  Pro Tyr Ile 
    1265                 1270                 1275             


Pro Ser  Asn Leu Cys Trp Leu  Ala Val Glu Asn Ala  Asp Ala Asn 
    1280                 1285                 1290             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Val Met Ile  Leu Lys Lys 
    1295                 1300                 1305             


Ile Arg  Glu His Ala Lys Lys  Asp Pro Glu Phe Lys  Lys Leu Pro 
    1310                 1315                 1320             


Asn Leu  Phe Ile Ser Asn Ala  Glu Trp Asp Glu Ala  Ala Arg Asp 
    1325                 1330                 1335             


Trp Gly  Lys Tyr Ala Gly Thr  Thr Ala Leu Asn Leu  Asp His 
    1340                 1345                 1350         


<210>  134
<211>  1206
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  134

Met Tyr Tyr Glu Ser Leu Thr Lys Gln Tyr Pro Val Ser Lys Thr Ile 
1               5                   10                  15      


Arg Asn Glu Leu Ile Pro Ile Gly Lys Thr Leu Asp Asn Ile Arg Gln 
            20                  25                  30          


Asn Asn Ile Leu Glu Ser Asp Val Lys Arg Lys Gln Asn Tyr Glu His 
        35                  40                  45              


Val Lys Gly Ile Leu Asp Glu Tyr His Lys Gln Leu Ile Asn Glu Ala 
    50                  55                  60                  


Leu Asp Asn Cys Thr Leu Pro Ser Leu Lys Ile Ala Ala Glu Ile Tyr 
65                  70                  75                  80  


Leu Lys Asn Gln Lys Glu Val Ser Asp Arg Glu Asp Phe Asn Lys Thr 
                85                  90                  95      


Gln Asp Leu Leu Arg Lys Glu Val Val Glu Lys Leu Lys Ala His Glu 
            100                 105                 110         


Asn Phe Thr Lys Ile Gly Lys Lys Asp Ile Leu Asp Leu Leu Glu Lys 
        115                 120                 125             


Leu Pro Ser Ile Ser Glu Asp Asp Tyr Asn Ala Leu Glu Ser Phe Arg 
    130                 135                 140                 


Asn Phe Tyr Thr Tyr Phe Thr Ser Tyr Asn Lys Val Arg Glu Asn Leu 
145                 150                 155                 160 


Tyr Ser Asp Lys Glu Lys Ser Ser Thr Val Ala Tyr Arg Leu Ile Asn 
                165                 170                 175     


Glu Asn Phe Pro Lys Phe Leu Asp Asn Val Lys Ser Tyr Arg Phe Val 
            180                 185                 190         


Lys Thr Ala Gly Ile Leu Ala Asp Gly Leu Gly Glu Glu Glu Gln Asp 
        195                 200                 205             


Ser Leu Phe Ile Val Glu Thr Phe Asn Lys Thr Leu Thr Gln Asp Gly 
    210                 215                 220                 


Ile Asp Thr Tyr Asn Ser Gln Val Gly Lys Ile Asn Ser Ser Ile Asn 
225                 230                 235                 240 


Leu Tyr Asn Gln Lys Asn Gln Lys Ala Asn Gly Phe Arg Lys Ile Pro 
                245                 250                 255     


Lys Met Lys Met Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Glu Ser 
            260                 265                 270         


Phe Ile Asp Glu Phe Gln Ser Asp Glu Val Leu Ile Asp Asn Val Glu 
        275                 280                 285             


Ser Tyr Gly Ser Val Leu Ile Glu Ser Leu Lys Ser Ser Lys Val Ser 
    290                 295                 300                 


Ala Phe Phe Asp Ala Leu Arg Glu Ser Lys Gly Lys Asn Val Tyr Val 
305                 310                 315                 320 


Lys Asn Asp Leu Ala Lys Thr Ala Met Ser Asn Ile Val Phe Glu Asn 
                325                 330                 335     


Trp Arg Thr Phe Asp Asp Leu Leu Asn Gln Glu Tyr Asp Leu Ala Asn 
            340                 345                 350         


Glu Asn Lys Lys Lys Asp Asp Lys Tyr Phe Glu Lys Arg Gln Lys Glu 
        355                 360                 365             


Leu Lys Lys Asn Lys Ser Tyr Ser Leu Glu His Leu Cys Asn Leu Ser 
    370                 375                 380                 


Glu Asp Ser Cys Asn Leu Ile Glu Asn Tyr Ile His Gln Ile Ser Asp 
385                 390                 395                 400 


Asp Ile Glu Asn Ile Ile Ile Asn Asn Glu Thr Phe Leu Arg Ile Val 
                405                 410                 415     


Ile Asn Glu His Asp Arg Ser Arg Lys Leu Ala Lys Asn Arg Lys Ala 
            420                 425                 430         


Val Lys Ala Ile Lys Asp Phe Leu Asp Ser Ile Lys Val Leu Glu Arg 
        435                 440                 445             


Glu Leu Lys Leu Ile Asn Ser Ser Gly Gln Glu Leu Glu Lys Asp Leu 
    450                 455                 460                 


Ile Val Tyr Ser Ala His Glu Glu Leu Leu Val Glu Leu Lys Gln Val 
465                 470                 475                 480 


Asp Ser Leu Tyr Asn Met Thr Arg Asn Tyr Leu Thr Lys Lys Pro Phe 
                485                 490                 495     


Ser Thr Glu Lys Val Lys Leu Asn Phe Asn Arg Ser Thr Leu Leu Asn 
            500                 505                 510         


Gly Trp Asp Arg Asn Lys Glu Thr Asp Asn Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Lys Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Thr Ser Ala Asn Lys 
    530                 535                 540                 


Ala Phe Val Asn Pro Pro Val Ala Lys Thr Glu Lys Val Phe Lys Lys 
545                 550                 555                 560 


Val Asp Tyr Lys Leu Leu Pro Val Pro Asn Gln Met Leu Pro Lys Val 
                565                 570                 575     


Phe Phe Ala Lys Ser Asn Ile Asp Phe Tyr Asn Pro Ser Ser Glu Ile 
            580                 585                 590         


Tyr Ser Asn Tyr Lys Lys Gly Thr His Lys Lys Gly Asn Met Phe Ser 
        595                 600                 605             


Leu Glu Asp Cys His Asn Leu Ile Asp Phe Phe Lys Glu Ser Ile Ser 
    610                 615                 620                 


Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Ser Asp Thr Ala 
625                 630                 635                 640 


Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val Glu Lys Gln Gly 
                645                 650                 655     


Tyr Lys Leu Thr Tyr Thr Asp Ile Asp Glu Thr Tyr Ile Asn Asp Leu 
            660                 665                 670         


Ile Glu Arg Asn Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
        675                 680                 685             


Ser Met Tyr Ser Lys Gly Lys Leu Asn Leu His Thr Leu Tyr Phe Met 
    690                 695                 700                 


Met Leu Phe Asp Gln Arg Asn Ile Asp Asp Val Val Tyr Lys Leu Asn 
705                 710                 715                 720 


Gly Glu Ala Glu Val Phe Tyr Arg Pro Ala Ser Ile Ser Glu Asp Glu 
                725                 730                 735     


Leu Ile Ile His Lys Ala Gly Glu Glu Ile Lys Asn Lys Asn Pro Asn 
            740                 745                 750         


Arg Ala Arg Thr Lys Glu Thr Ser Thr Phe Ser Tyr Asp Ile Val Lys 
        755                 760                 765             


Asp Lys Arg Tyr Ser Lys Asp Lys Phe Thr Leu His Ile Pro Ile Thr 
    770                 775                 780                 


Met Asn Phe Gly Val Asp Glu Val Lys Arg Phe Asn Asp Ala Val Asn 
785                 790                 795                 800 


Ser Ala Ile Arg Ile Asp Glu Asn Val Asn Val Ile Gly Ile Asp Arg 
                805                 810                 815     


Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Ser Lys Gly Asn 
            820                 825                 830         


Ile Leu Glu Gln Ile Ser Leu Asn Ser Ile Ile Asn Lys Glu Tyr Asp 
        835                 840                 845             


Ile Glu Thr Asp Tyr His Ala Leu Leu Asp Glu Arg Glu Gly Gly Arg 
    850                 855                 860                 


Asp Lys Ala Arg Lys Asp Trp Asn Thr Val Glu Asn Ile Arg Asp Leu 
865                 870                 875                 880 


Lys Ala Gly Tyr Leu Ser Gln Val Val Asn Val Val Ala Lys Leu Val 
                885                 890                 895     


Leu Lys Tyr Asn Ala Ile Ile Cys Leu Glu Asp Leu Asn Phe Gly Phe 
            900                 905                 910         


Lys Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu 
        915                 920                 925             


Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Ile Asp Lys Ser Arg 
    930                 935                 940                 


Glu Gln Thr Ser Pro Lys Glu Leu Gly Gly Ala Leu Asn Ala Leu Gln 
945                 950                 955                 960 


Leu Thr Ser Lys Phe Lys Ser Phe Lys Glu Leu Gly Lys Gln Ser Gly 
                965                 970                 975     


Val Ile Tyr Tyr Val Pro Ala Tyr Leu Thr Ser Lys Ile Asp Pro Thr 
            980                 985                 990         


Thr Gly Phe Ala Asn Leu Phe Tyr  Met Lys Cys Glu Asn  Val Glu Lys 
        995                 1000                 1005             


Ser Lys  Arg Phe Phe Asp Gly  Phe Asp Phe Ile Arg  Phe Asn Ala 
    1010                 1015                 1020             


Leu Glu  Asn Val Phe Glu Phe  Gly Phe Asp Tyr Arg  Ser Phe Thr 
    1025                 1030                 1035             


Gln Arg  Ala Cys Gly Ile Asn  Ser Lys Trp Thr Val  Cys Thr Asn 
    1040                 1045                 1050             


Gly Glu  Arg Ile Ile Lys Tyr  Arg Asn Pro Asp Lys  Asn Asn Met 
    1055                 1060                 1065             


Phe Asp  Glu Lys Val Val Val  Val Thr Asp Glu Met  Lys Asn Leu 
    1070                 1075                 1080             


Phe Glu  Gln Tyr Lys Ile Pro  Tyr Glu Asp Gly Arg  Asn Val Lys 
    1085                 1090                 1095             


Asp Met  Ile Ile Ser Asn Glu  Glu Ala Glu Phe Tyr  Arg Arg Leu 
    1100                 1105                 1110             


Tyr Arg  Leu Leu Gln Gln Thr  Leu Gln Met Arg Asn  Ser Thr Ser 
    1115                 1120                 1125             


Asp Gly  Thr Arg Asp Tyr Ile  Ile Ser Pro Val Lys  Asn Lys Arg 
    1130                 1135                 1140             


Glu Ala  Tyr Phe Asn Ser Glu  Leu Ser Asp Gly Ser  Val Pro Lys 
    1145                 1150                 1155             


Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu 
    1160                 1165                 1170             


Trp Val  Leu Glu Gln Ile Arg  Gln Lys Ser Glu Gly  Glu Lys Ile 
    1175                 1180                 1185             


Asn Leu  Ala Met Thr Asn Ala  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1190                 1195                 1200             


His Leu  Leu 
    1205     


<210>  135
<211>  1238
<212>  PRT
<213>  Candidatus Methanoplasma termitum

<400>  135

Met Asn Asn Tyr Asp Glu Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Met Glu His Leu Glu 
            20                  25                  30          


Thr Phe Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Ala Ile Asp Glu Tyr His Lys Lys Phe Ile Asp Glu 
    50                  55                  60                  


His Leu Thr Asn Met Ser Leu Asp Trp Asn Ser Leu Lys Gln Ile Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Lys Ser Arg Glu Glu Lys Asp Lys Lys Val Phe Leu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Arg Gln Glu Ile Val Ser Glu Phe Lys Lys 
            100                 105                 110         


Asp Asp Arg Phe Lys Asp Leu Phe Ser Lys Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Lys Glu Glu Ile Tyr Lys Lys Gly Asn His Gln Glu Ile Asp Ala 
    130                 135                 140                 


Leu Lys Ser Phe Asp Lys Phe Ser Gly Tyr Phe Ile Gly Leu His Glu 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Asp Gly Asp Glu Ile Thr Ala Ile Ser 
                165                 170                 175     


Asn Arg Ile Val Asn Glu Asn Phe Pro Lys Phe Leu Asp Asn Leu Gln 
            180                 185                 190         


Lys Tyr Gln Glu Ala Arg Lys Lys Tyr Pro Glu Trp Ile Ile Lys Ala 
        195                 200                 205             


Glu Ser Ala Leu Val Ala His Asn Ile Lys Met Asp Glu Val Phe Ser 
    210                 215                 220                 


Leu Glu Tyr Phe Asn Lys Val Leu Asn Gln Glu Gly Ile Gln Arg Tyr 
225                 230                 235                 240 


Asn Leu Ala Leu Gly Gly Tyr Val Thr Lys Ser Gly Glu Lys Met Met 
                245                 250                 255     


Gly Leu Asn Asp Ala Leu Asn Leu Ala His Gln Ser Glu Lys Ser Ser 
            260                 265                 270         


Lys Gly Arg Ile His Met Thr Pro Leu Phe Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Glu Ser Phe Ser Tyr Ile Pro Asp Val Phe Thr Glu Asp Ser Gln 
    290                 295                 300                 


Leu Leu Pro Ser Ile Gly Gly Phe Phe Ala Gln Ile Glu Asn Asp Lys 
305                 310                 315                 320 


Asp Gly Asn Ile Phe Asp Arg Ala Leu Glu Leu Ile Ser Ser Tyr Ala 
                325                 330                 335     


Glu Tyr Asp Thr Glu Arg Ile Tyr Ile Arg Gln Ala Asp Ile Asn Arg 
            340                 345                 350         


Val Ser Asn Val Ile Phe Gly Glu Trp Gly Thr Leu Gly Gly Leu Met 
        355                 360                 365             


Arg Glu Tyr Lys Ala Asp Ser Ile Asn Asp Ile Asn Leu Glu Arg Thr 
    370                 375                 380                 


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Lys Glu Phe Ala Leu Ser 
385                 390                 395                 400 


Asp Val Leu Glu Ala Ile Lys Arg Thr Gly Asn Asn Asp Ala Phe Asn 
                405                 410                 415     


Glu Tyr Ile Ser Lys Met Arg Thr Ala Arg Glu Lys Ile Asp Ala Ala 
            420                 425                 430         


Arg Lys Glu Met Lys Phe Ile Ser Glu Lys Ile Ser Gly Asp Glu Glu 
        435                 440                 445             


Ser Ile His Ile Ile Lys Thr Leu Leu Asp Ser Val Gln Gln Phe Leu 
    450                 455                 460                 


His Phe Phe Asn Leu Phe Lys Ala Arg Gln Asp Ile Pro Leu Asp Gly 
465                 470                 475                 480 


Ala Phe Tyr Ala Glu Phe Asp Glu Val His Ser Lys Leu Phe Ala Ile 
                485                 490                 495     


Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Lys Asn Asn Leu 
            500                 505                 510         


Asn Thr Lys Lys Ile Lys Leu Asn Phe Lys Asn Pro Thr Leu Ala Asn 
        515                 520                 525             


Gly Trp Asp Gln Asn Lys Val Tyr Asp Tyr Ala Ser Leu Ile Phe Leu 
    530                 535                 540                 


Arg Asp Gly Asn Tyr Tyr Leu Gly Ile Ile Asn Pro Lys Arg Lys Lys 
545                 550                 555                 560 


Asn Ile Lys Phe Glu Gln Gly Ser Gly Asn Gly Pro Phe Tyr Arg Lys 
                565                 570                 575     


Met Val Tyr Lys Gln Ile Pro Gly Pro Asn Lys Asn Leu Pro Arg Val 
            580                 585                 590         


Phe Leu Thr Ser Thr Lys Gly Lys Lys Glu Tyr Lys Pro Ser Lys Glu 
        595                 600                 605             


Ile Ile Glu Gly Tyr Glu Ala Asp Lys His Ile Arg Gly Asp Lys Phe 
    610                 615                 620                 


Asp Leu Asp Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
625                 630                 635                 640 


Glu Lys His Lys Asp Trp Ser Lys Phe Asn Phe Tyr Phe Ser Pro Thr 
                645                 650                 655     


Glu Ser Tyr Gly Asp Ile Ser Glu Phe Tyr Leu Asp Val Glu Lys Gln 
            660                 665                 670         


Gly Tyr Arg Met His Phe Glu Asn Ile Ser Ala Glu Thr Ile Asp Glu 
        675                 680                 685             


Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
    690                 695                 700                 


Phe Val Lys Ala Ala Thr Gly Lys Lys Asp Met His Thr Ile Tyr Trp 
705                 710                 715                 720 


Asn Ala Ala Phe Ser Pro Glu Asn Leu Gln Asp Val Val Val Lys Leu 
                725                 730                 735     


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp Lys Ser Asp Ile Lys Glu 
            740                 745                 750         


Ile Val His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Asn Gly 
        755                 760                 765             


Arg Thr Pro Val Pro Asp Lys Ile His Lys Lys Leu Thr Asp Tyr His 
    770                 775                 780                 


Asn Gly Arg Thr Lys Asp Leu Gly Glu Ala Lys Glu Tyr Leu Asp Lys 
785                 790                 795                 800 


Val Arg Tyr Phe Lys Ala His Tyr Asp Ile Thr Lys Asp Arg Arg Tyr 
                805                 810                 815     


Leu Asn Asp Lys Ile Tyr Phe His Val Pro Leu Thr Leu Asn Phe Lys 
            820                 825                 830         


Ala Asn Gly Lys Lys Asn Leu Asn Lys Met Val Ile Glu Lys Phe Leu 
        835                 840                 845             


Ser Asp Glu Lys Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Ser Gly Lys Ile Ile Asp Gln 
865                 870                 875                 880 


Gln Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr Arg Glu Lys Leu Asn 
                885                 890                 895     


Gln Arg Glu Ile Glu Met Lys Asp Ala Arg Gln Ser Trp Asn Ala Ile 
            900                 905                 910         


Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Lys Ala Val His 
        915                 920                 925             


Glu Ile Thr Lys Met Ala Ile Gln Tyr Asn Ala Ile Val Val Met Glu 
    930                 935                 940                 


Glu Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Phe Glu Asn Met Leu Ile Asp Lys Met Asn Tyr Leu 
                965                 970                 975     


Val Phe Lys Asp Ala Pro Asp Glu Ser Pro Gly Gly Val Leu Asn Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Pro Leu Glu  Ser Phe Ala Lys Leu  Gly Lys Gln 
        995                 1000                 1005             


Thr Gly  Ile Leu Phe Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile 
    1010                 1015                 1020             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Thr  Ser Ser Lys 
    1025                 1030                 1035             


Thr Asn  Ala Gln Glu Arg Lys  Glu Phe Leu Gln Lys  Phe Glu Ser 
    1040                 1045                 1050             


Ile Ser  Tyr Ser Ala Lys Asp  Gly Gly Ile Phe Ala  Phe Ala Phe 
    1055                 1060                 1065             


Asp Tyr  Arg Lys Phe Gly Thr  Ser Lys Thr Asp His  Lys Asn Val 
    1070                 1075                 1080             


Trp Thr  Ala Tyr Thr Asn Gly  Glu Arg Met Arg Tyr  Ile Lys Glu 
    1085                 1090                 1095             


Lys Lys  Arg Asn Glu Leu Phe  Asp Pro Ser Lys Glu  Ile Lys Glu 
    1100                 1105                 1110             


Ala Leu  Thr Ser Ser Gly Ile  Lys Tyr Asp Gly Gly  Gln Asn Ile 
    1115                 1120                 1125             


Leu Pro  Asp Ile Leu Arg Ser  Asn Asn Asn Gly Leu  Ile Tyr Thr 
    1130                 1135                 1140             


Met Tyr  Ser Ser Phe Ile Ala  Ala Ile Gln Met Arg  Val Tyr Asp 
    1145                 1150                 1155             


Gly Lys  Glu Asp Tyr Ile Ile  Ser Pro Ile Lys Asn  Ser Lys Gly 
    1160                 1165                 1170             


Glu Phe  Phe Arg Thr Asp Pro  Lys Arg Arg Glu Leu  Pro Ile Asp 
    1175                 1180                 1185             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Arg  Gly Glu Leu 
    1190                 1195                 1200             


Thr Met  Arg Ala Ile Ala Glu  Lys Phe Asp Pro Asp  Ser Glu Lys 
    1205                 1210                 1215             


Met Ala  Lys Leu Glu Leu Lys  His Lys Asp Trp Phe  Glu Phe Met 
    1220                 1225                 1230             


Gln Thr  Arg Gly Asp 
    1235             


<210>  136
<211>  1282
<212>  PRT
<213>  Eubacterium eligens

<400>  136

Met Asn Gly Asn Arg Ser Ile Val Tyr Arg Glu Phe Val Gly Val Ile 
1               5                   10                  15      


Pro Val Ala Lys Thr Leu Arg Asn Glu Leu Arg Pro Val Gly His Thr 
            20                  25                  30          


Gln Glu His Ile Ile Gln Asn Gly Leu Ile Gln Glu Asp Glu Leu Arg 
        35                  40                  45              


Gln Glu Lys Ser Thr Glu Leu Lys Asn Ile Met Asp Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Tyr Ile Asp Lys Ser Leu Ser Gly Val Thr Asp Leu Asp Phe Thr 
65                  70                  75                  80  


Leu Leu Phe Glu Leu Met Asn Leu Val Gln Ser Ser Pro Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Ala Leu Glu Lys Glu Gln Ser Lys Met Arg Glu Gln Ile 
            100                 105                 110         


Cys Thr His Leu Gln Ser Asp Ser Asn Tyr Lys Asn Ile Phe Asn Ala 
        115                 120                 125             


Lys Leu Leu Lys Glu Ile Leu Pro Asp Phe Ile Lys Asn Tyr Asn Gln 
    130                 135                 140                 


Tyr Asp Val Lys Asp Lys Ala Gly Lys Leu Glu Thr Leu Ala Leu Phe 
145                 150                 155                 160 


Asn Gly Phe Ser Thr Tyr Phe Thr Asp Phe Phe Glu Lys Arg Lys Asn 
                165                 170                 175     


Val Phe Thr Lys Glu Ala Val Ser Thr Ser Ile Ala Tyr Arg Ile Val 
            180                 185                 190         


His Glu Asn Ser Leu Ile Phe Leu Ala Asn Met Thr Ser Tyr Lys Lys 
        195                 200                 205             


Ile Ser Glu Lys Ala Leu Asp Glu Ile Glu Val Ile Glu Lys Asn Asn 
    210                 215                 220                 


Gln Asp Lys Met Gly Asp Trp Glu Leu Asn Gln Ile Phe Asn Pro Asp 
225                 230                 235                 240 


Phe Tyr Asn Met Val Leu Ile Gln Ser Gly Ile Asp Phe Tyr Asn Glu 
                245                 250                 255     


Ile Cys Gly Val Val Asn Ala His Met Asn Leu Tyr Cys Gln Gln Thr 
            260                 265                 270         


Lys Asn Asn Tyr Asn Leu Phe Lys Met Arg Lys Leu His Lys Gln Ile 
        275                 280                 285             


Leu Ala Tyr Thr Ser Thr Ser Phe Glu Val Pro Lys Met Phe Glu Asp 
    290                 295                 300                 


Asp Met Ser Val Tyr Asn Ala Val Asn Ala Phe Ile Asp Glu Thr Glu 
305                 310                 315                 320 


Lys Gly Asn Ile Ile Gly Lys Leu Lys Asp Ile Val Asn Lys Tyr Asp 
                325                 330                 335     


Glu Leu Asp Glu Lys Arg Ile Tyr Ile Ser Lys Asp Phe Tyr Glu Thr 
            340                 345                 350         


Leu Ser Cys Phe Met Ser Gly Asn Trp Asn Leu Ile Thr Gly Cys Val 
        355                 360                 365             


Glu Asn Phe Tyr Asp Glu Asn Ile His Ala Lys Gly Lys Ser Lys Glu 
    370                 375                 380                 


Glu Lys Val Lys Lys Ala Val Lys Glu Asp Lys Tyr Lys Ser Ile Asn 
385                 390                 395                 400 


Asp Val Asn Asp Leu Val Glu Lys Tyr Ile Asp Glu Lys Glu Arg Asn 
                405                 410                 415     


Glu Phe Lys Asn Ser Asn Ala Lys Gln Tyr Ile Arg Glu Ile Ser Asn 
            420                 425                 430         


Ile Ile Thr Asp Thr Glu Thr Ala His Leu Glu Tyr Asp Asp His Ile 
        435                 440                 445             


Ser Leu Ile Glu Ser Glu Glu Lys Ala Asp Glu Met Lys Lys Arg Leu 
    450                 455                 460                 


Asp Met Tyr Met Asn Met Tyr His Trp Ala Lys Ala Phe Ile Val Asp 
465                 470                 475                 480 


Glu Val Leu Asp Arg Asp Glu Met Phe Tyr Ser Asp Ile Asp Asp Ile 
                485                 490                 495     


Tyr Asn Ile Leu Glu Asn Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
            500                 505                 510         


Tyr Val Thr Gln Lys Pro Tyr Asn Ser Lys Lys Ile Lys Leu Asn Phe 
        515                 520                 525             


Gln Ser Pro Thr Leu Ala Asn Gly Trp Ser Gln Ser Lys Glu Phe Asp 
    530                 535                 540                 


Asn Asn Ala Ile Ile Leu Ile Arg Asp Asn Lys Tyr Tyr Leu Ala Ile 
545                 550                 555                 560 


Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Gln Gly Asn Ser 
                565                 570                 575     


Asp Lys Lys Asn Asp Asn Asp Tyr Lys Lys Met Val Tyr Asn Leu Leu 
            580                 585                 590         


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Leu Ser Lys Lys Gly 
        595                 600                 605             


Ile Glu Thr Phe Lys Pro Ser Asp Tyr Ile Ile Ser Gly Tyr Asn Ala 
    610                 615                 620                 


His Lys His Ile Lys Thr Ser Glu Asn Phe Asp Ile Ser Phe Cys Arg 
625                 630                 635                 640 


Asp Leu Ile Asp Tyr Phe Lys Asn Ser Ile Glu Lys His Ala Glu Trp 
                645                 650                 655     


Arg Lys Tyr Glu Phe Lys Phe Ser Ala Thr Asp Ser Tyr Ser Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Val Glu Met Gln Gly Tyr Arg Ile Asp Trp 
        675                 680                 685             


Thr Tyr Ile Ser Glu Ala Asp Ile Asn Lys Leu Asp Glu Glu Gly Lys 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Glu Asn Ser Thr 
705                 710                 715                 720 


Gly Lys Glu Asn Leu His Thr Met Tyr Phe Lys Asn Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Lys Asp Ile Ile Ile Lys Leu Asn Gly Gln Ala Glu Leu 
            740                 745                 750         


Phe Tyr Arg Arg Ala Ser Val Lys Asn Pro Val Lys His Lys Lys Asp 
        755                 760                 765             


Ser Val Leu Val Asn Lys Thr Tyr Lys Asn Gln Leu Asp Asn Gly Asp 
    770                 775                 780                 


Val Val Arg Ile Pro Ile Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Lys 
785                 790                 795                 800 


Met Tyr Asn Gly Tyr Ile Lys Glu Ser Asp Leu Ser Glu Ala Ala Lys 
                805                 810                 815     


Glu Tyr Leu Asp Lys Val Glu Val Arg Thr Ala Gln Lys Asp Ile Val 
            820                 825                 830         


Lys Asp Tyr Arg Tyr Thr Val Asp Lys Tyr Phe Ile His Thr Pro Ile 
        835                 840                 845             


Thr Ile Asn Tyr Lys Val Thr Ala Arg Asn Asn Val Asn Asp Met Val 
    850                 855                 860                 


Val Lys Tyr Ile Ala Gln Asn Asp Asp Ile His Val Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg Asn Leu Ile Tyr Ile Ser Val Ile Asp Ser His Gly 
                885                 890                 895     


Asn Ile Val Lys Gln Lys Ser Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr 
            900                 905                 910         


Lys Lys Lys Leu Val Glu Lys Glu Lys Thr Arg Glu Tyr Ala Arg Lys 
        915                 920                 925             


Asn Trp Lys Ser Ile Gly Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile 
    930                 935                 940                 


Ser Gly Val Val His Glu Ile Ala Met Leu Ile Val Glu Tyr Asn Ala 
945                 950                 955                 960 


Ile Ile Ala Met Glu Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe 
                965                 970                 975     


Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn 
            980                 985                 990         


Lys Leu Asn Tyr Phe Ala Ser Lys  Glu Lys Ser Val Asp  Glu Pro Gly 
        995                 1000                 1005             


Gly Leu  Leu Lys Gly Tyr Gln  Leu Thr Tyr Val Pro  Asp Asn Ile 
    1010                 1015                 1020             


Lys Asn  Leu Gly Lys Gln Cys  Gly Val Ile Phe Tyr  Val Pro Ala 
    1025                 1030                 1035             


Ala Phe  Thr Ser Lys Ile Asp  Pro Ser Thr Gly Phe  Ile Ser Ala 
    1040                 1045                 1050             


Phe Asn  Phe Lys Ser Ile Ser  Thr Asn Ala Ser Arg  Lys Gln Phe 
    1055                 1060                 1065             


Phe Met  Gln Phe Asp Glu Ile  Arg Tyr Cys Ala Glu  Lys Asp Met 
    1070                 1075                 1080             


Phe Ser  Phe Gly Phe Asp Tyr  Asn Asn Phe Asp Thr  Tyr Asn Ile 
    1085                 1090                 1095             


Thr Met  Gly Lys Thr Gln Trp  Thr Val Tyr Thr Asn  Gly Glu Arg 
    1100                 1105                 1110             


Leu Gln  Ser Glu Phe Asn Asn  Ala Arg Arg Thr Gly  Lys Thr Lys 
    1115                 1120                 1125             


Ser Ile  Asn Leu Thr Glu Thr  Ile Lys Leu Leu Leu  Glu Asp Asn 
    1130                 1135                 1140             


Glu Ile  Asn Tyr Ala Asp Gly  His Asp Ile Arg Ile  Asp Met Glu 
    1145                 1150                 1155             


Lys Met  Asp Glu Asp Lys Lys  Ser Glu Phe Phe Ala  Gln Leu Leu 
    1160                 1165                 1170             


Ser Leu  Tyr Lys Leu Thr Val  Gln Met Arg Asn Ser  Tyr Thr Glu 
    1175                 1180                 1185             


Ala Glu  Glu Gln Glu Asn Gly  Ile Ser Tyr Asp Lys  Ile Ile Ser 
    1190                 1195                 1200             


Pro Val  Ile Asn Asp Glu Gly  Glu Phe Phe Asp Ser  Asp Asn Tyr 
    1205                 1210                 1215             


Lys Glu  Ser Asp Asp Lys Glu  Cys Lys Met Pro Lys  Asp Ala Asp 
    1220                 1225                 1230             


Ala Asn  Gly Ala Tyr Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Val 
    1235                 1240                 1245             


Leu Lys  Ile Lys Ser Glu Trp  Thr Glu Asp Gly Phe  Asp Arg Asn 
    1250                 1255                 1260             


Cys Leu  Lys Leu Pro His Ala  Glu Trp Leu Asp Phe  Ile Gln Asn 
    1265                 1270                 1275             


Lys Arg  Tyr Glu 
    1280         


<210>  137
<211>  1373
<212>  PRT
<213>  Moraxella bovoculi

<400>  137

Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ile Asp Arg Thr Leu Glu His Ile His Ala 
            20                  25                  30          


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met His Gln Lys 
        35                  40                  45              


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
    50                  55                  60                  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
65                  70                  75                  80  


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Glu Leu Gln Lys Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ile Val Lys Pro Ile Gly 
            100                 105                 110         


Asn Gly Gly Lys Tyr Lys Ala Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Thr Leu Leu 
                245                 250                 255     


Gly Gly Ile Ser Gly Glu Ala Gly Ser Pro Lys Ile Gln Gly Ile Asn 
            260                 265                 270         


Glu Leu Ile Asn Ser His His Asn Gln His Cys His Lys Ser Glu Arg 
        275                 280                 285             


Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met 
    290                 295                 300                 


Ser Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys 
305                 310                 315                 320 


Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Ala Asp Val Phe Ala Lys 
                325                 330                 335     


Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile 
            340                 345                 350         


Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly 
        355                 360                 365             


Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val 
    370                 375                 380                 


Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn 
385                 390                 395                 400 


Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val 
                405                 410                 415     


His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His Tyr Thr Ala Arg 
            420                 425                 430         


His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys 
        435                 440                 445             


His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn 
    450                 455                 460                 


His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu 
465                 470                 475                 480 


Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln 
                485                 490                 495     


Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His 
            500                 505                 510         


Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly 
        515                 520                 525             


Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile 
    530                 535                 540                 


Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe 
545                 550                 555                 560 


Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn 
                565                 570                 575     


Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln 
            580                 585                 590         


Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys 
        595                 600                 605             


Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Ser Ile Tyr Gln Lys Met 
    610                 615                 620                 


Ile Tyr Lys Tyr Leu Glu Val Arg Lys Gln Phe Pro Lys Val Phe Phe 
625                 630                 635                 640 


Ser Lys Glu Ala Ile Ala Ile Asn Tyr His Pro Ser Lys Glu Leu Val 
                645                 650                 655     


Glu Ile Lys Asp Lys Gly Arg Gln Arg Ser Asp Asp Glu Arg Leu Lys 
            660                 665                 670         


Leu Tyr Arg Phe Ile Leu Glu Cys Leu Lys Ile His Pro Lys Tyr Asp 
        675                 680                 685             


Lys Lys Phe Glu Gly Ala Ile Gly Asp Ile Gln Leu Phe Lys Lys Asp 
    690                 695                 700                 


Lys Lys Gly Arg Glu Val Pro Ile Ser Glu Lys Asp Leu Phe Asp Lys 
705                 710                 715                 720 


Ile Asn Gly Ile Phe Ser Ser Lys Pro Lys Leu Glu Met Glu Asp Phe 
                725                 730                 735     


Phe Ile Gly Glu Phe Lys Arg Tyr Asn Pro Ser Gln Asp Leu Val Asp 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Lys Lys Ile Asp Ser Asn Asp Asn Arg Lys Lys 
        755                 760                 765             


Glu Asn Phe Tyr Asn Asn His Pro Lys Phe Lys Lys Asp Leu Val Arg 
    770                 775                 780                 


Tyr Tyr Tyr Glu Ser Met Cys Lys His Glu Glu Trp Glu Glu Ser Phe 
785                 790                 795                 800 


Glu Phe Ser Lys Lys Leu Gln Asp Ile Gly Cys Tyr Val Asp Val Asn 
                805                 810                 815     


Glu Leu Phe Thr Glu Ile Glu Thr Arg Arg Leu Asn Tyr Lys Ile Ser 
            820                 825                 830         


Phe Cys Asn Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly 
        835                 840                 845             


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala 
    850                 855                 860                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser 
865                 870                 875                 880 


Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln 
                885                 890                 895     


Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His 
            900                 905                 910         


Arg Ala Gly Glu Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys 
        915                 920                 925             


Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp 
    930                 935                 940                 


Lys Phe Met Leu His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly 
945                 950                 955                 960 


Met Thr Ile Lys Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln 
                965                 970                 975     


Tyr Asp Glu Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu 
            980                 985                 990         


Leu Tyr Leu Thr Val Ile Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Cys 
        995                 1000                 1005             


Ser Leu  Asn Asp Ile Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Met 
    1010                 1015                 1020             


Thr Thr  Pro Tyr His Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Asn  Ala Arg Val Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu 
    1040                 1045                 1050             


Leu Lys  Ser Gly Tyr Leu Ser  His Val Val His Gln  Ile Ser Gln 
    1055                 1060                 1065             


Leu Met  Leu Lys Tyr Asn Ala  Ile Val Val Leu Glu  Asp Leu Asn 
    1070                 1075                 1080             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr 
    1085                 1090                 1095             


Gln Asn  Phe Glu Asn Ala Leu  Ile Lys Lys Leu Asn  His Leu Val 
    1100                 1105                 1110             


Leu Lys  Asp Lys Ala Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala 
    1115                 1120                 1125             


Leu Gln  Leu Thr Asn Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys 
    1130                 1135                 1140             


Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys 
    1145                 1150                 1155             


Ile Asp  Pro Glu Thr Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr 
    1160                 1165                 1170             


Glu Asn  Ile Ala Gln Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys 
    1175                 1180                 1185             


Ile Cys  Tyr Asn Ala Asp Lys  Asp Tyr Phe Glu Phe  His Ile Asp 
    1190                 1195                 1200             


Tyr Ala  Lys Phe Thr Asp Lys  Ala Lys Asn Ser Arg  Gln Ile Trp 
    1205                 1210                 1215             


Thr Ile  Cys Ser His Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr 
    1220                 1225                 1230             


Ala Asn  Gln Asn Lys Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp 
    1235                 1240                 1245             


Glu Leu  Lys Ser Leu Phe Ala  Arg His His Ile Asn  Glu Lys Gln 
    1250                 1255                 1260             


Pro Asn  Leu Val Met Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe 
    1265                 1270                 1275             


His Lys  Ser Leu Met Tyr Leu  Leu Lys Thr Leu Leu  Ala Leu Arg 
    1280                 1285                 1290             


Tyr Ser  Asn Ala Ser Ser Asp  Glu Asp Phe Ile Leu  Ser Pro Val 
    1295                 1300                 1305             


Ala Asn  Asp Glu Gly Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp 
    1310                 1315                 1320             


Thr Gln  Pro Gln Asn Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1325                 1330                 1335             


Leu Lys  Gly Leu Trp Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp 
    1340                 1345                 1350             


Leu Asn  Lys Val Lys Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn 
    1355                 1360                 1365             


Phe Ala  Gln Asn Arg 
    1370             


<210>  138
<211>  1323
<212>  PRT
<213>  Prevotella disiens

<400>  138

Met Glu Asn Tyr Gln Glu Phe Thr Asn Leu Phe Gln Leu Asn Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Cys Glu Leu Leu Glu 
            20                  25                  30          


Glu Gly Lys Ile Phe Ala Ser Gly Ser Phe Leu Glu Lys Asp Lys Val 
        35                  40                  45              


Arg Ala Asp Asn Val Ser Tyr Val Lys Lys Glu Ile Asp Lys Lys His 
    50                  55                  60                  


Lys Ile Phe Ile Glu Glu Thr Leu Ser Ser Phe Ser Ile Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Lys Gln Tyr Phe Asp Cys Tyr Asn Glu Leu Lys Ala Phe Lys 
                85                  90                  95      


Lys Asp Cys Lys Ser Asp Glu Glu Glu Val Lys Lys Thr Ala Leu Arg 
            100                 105                 110         


Asn Lys Cys Thr Ser Ile Gln Arg Ala Met Arg Glu Ala Ile Ser Gln 
        115                 120                 125             


Ala Phe Leu Lys Ser Pro Gln Lys Lys Leu Leu Ala Ile Lys Asn Leu 
    130                 135                 140                 


Ile Glu Asn Val Phe Lys Ala Asp Glu Asn Val Gln His Phe Ser Glu 
145                 150                 155                 160 


Phe Thr Ser Tyr Phe Ser Gly Phe Glu Thr Asn Arg Glu Asn Phe Tyr 
                165                 170                 175     


Ser Asp Glu Glu Lys Ser Thr Ser Ile Ala Tyr Arg Leu Val His Asp 
            180                 185                 190         


Asn Leu Pro Ile Phe Ile Lys Asn Ile Tyr Ile Phe Glu Lys Leu Lys 
        195                 200                 205             


Glu Gln Phe Asp Ala Lys Thr Leu Ser Glu Ile Phe Glu Asn Tyr Lys 
    210                 215                 220                 


Leu Tyr Val Ala Gly Ser Ser Leu Asp Glu Val Phe Ser Leu Glu Tyr 
225                 230                 235                 240 


Phe Asn Asn Thr Leu Thr Gln Lys Gly Ile Asp Asn Tyr Asn Ala Val 
                245                 250                 255     


Ile Gly Lys Ile Val Lys Glu Asp Lys Gln Glu Ile Gln Gly Leu Asn 
            260                 265                 270         


Glu His Ile Asn Leu Tyr Asn Gln Lys His Lys Asp Arg Arg Leu Pro 
        275                 280                 285             


Phe Phe Ile Ser Leu Lys Lys Gln Ile Leu Ser Asp Arg Glu Ala Leu 
    290                 295                 300                 


Ser Trp Leu Pro Asp Met Phe Lys Asn Asp Ser Glu Val Ile Lys Ala 
305                 310                 315                 320 


Leu Lys Gly Phe Tyr Ile Glu Asp Gly Phe Glu Asn Asn Val Leu Thr 
                325                 330                 335     


Pro Leu Ala Thr Leu Leu Ser Ser Leu Asp Lys Tyr Asn Leu Asn Gly 
            340                 345                 350         


Ile Phe Ile Arg Asn Asn Glu Ala Leu Ser Ser Leu Ser Gln Asn Val 
        355                 360                 365             


Tyr Arg Asn Phe Ser Ile Asp Glu Ala Ile Asp Ala Asn Ala Glu Leu 
    370                 375                 380                 


Gln Thr Phe Asn Asn Tyr Glu Leu Ile Ala Asn Ala Leu Arg Ala Lys 
385                 390                 395                 400 


Ile Lys Lys Glu Thr Lys Gln Gly Arg Lys Ser Phe Glu Lys Tyr Glu 
                405                 410                 415     


Glu Tyr Ile Asp Lys Lys Val Lys Ala Ile Asp Ser Leu Ser Ile Gln 
            420                 425                 430         


Glu Ile Asn Glu Leu Val Glu Asn Tyr Val Ser Glu Phe Asn Ser Asn 
        435                 440                 445             


Ser Gly Asn Met Pro Arg Lys Val Glu Asp Tyr Phe Ser Leu Met Arg 
    450                 455                 460                 


Lys Gly Asp Phe Gly Ser Asn Asp Leu Ile Glu Asn Ile Lys Thr Lys 
465                 470                 475                 480 


Leu Ser Ala Ala Glu Lys Leu Leu Gly Thr Lys Tyr Gln Glu Thr Ala 
                485                 490                 495     


Lys Asp Ile Phe Lys Lys Asp Glu Asn Ser Lys Leu Ile Lys Glu Leu 
            500                 505                 510         


Leu Asp Ala Thr Lys Gln Phe Gln His Phe Ile Lys Pro Leu Leu Gly 
        515                 520                 525             


Thr Gly Glu Glu Ala Asp Arg Asp Leu Val Phe Tyr Gly Asp Phe Leu 
    530                 535                 540                 


Pro Leu Tyr Glu Lys Phe Glu Glu Leu Thr Leu Leu Tyr Asn Lys Val 
545                 550                 555                 560 


Arg Asn Arg Leu Thr Gln Lys Pro Tyr Ser Lys Asp Lys Ile Arg Leu 
                565                 570                 575     


Cys Phe Asn Lys Pro Lys Leu Met Thr Gly Trp Val Asp Ser Lys Thr 
            580                 585                 590         


Glu Lys Ser Asp Asn Gly Thr Gln Tyr Gly Gly Tyr Leu Phe Arg Lys 
        595                 600                 605             


Lys Asn Glu Ile Gly Glu Tyr Asp Tyr Phe Leu Gly Ile Ser Ser Lys 
    610                 615                 620                 


Ala Gln Leu Phe Arg Lys Asn Glu Ala Val Ile Gly Asp Tyr Glu Arg 
625                 630                 635                 640 


Leu Asp Tyr Tyr Gln Pro Lys Ala Asn Thr Ile Tyr Gly Ser Ala Tyr 
                645                 650                 655     


Glu Gly Glu Asn Ser Tyr Lys Glu Asp Lys Lys Arg Leu Asn Lys Val 
            660                 665                 670         


Ile Ile Ala Tyr Ile Glu Gln Ile Lys Gln Thr Asn Ile Lys Lys Ser 
        675                 680                 685             


Ile Ile Glu Ser Ile Ser Lys Tyr Pro Asn Ile Ser Asp Asp Asp Lys 
    690                 695                 700                 


Val Thr Pro Ser Ser Leu Leu Glu Lys Ile Lys Lys Val Ser Ile Asp 
705                 710                 715                 720 


Ser Tyr Asn Gly Ile Leu Ser Phe Lys Ser Phe Gln Ser Val Asn Lys 
                725                 730                 735     


Glu Val Ile Asp Asn Leu Leu Lys Thr Ile Ser Pro Leu Lys Asn Lys 
            740                 745                 750         


Ala Glu Phe Leu Asp Leu Ile Asn Lys Asp Tyr Gln Ile Phe Thr Glu 
        755                 760                 765             


Val Gln Ala Val Ile Asp Glu Ile Cys Lys Gln Lys Thr Phe Ile Tyr 
    770                 775                 780                 


Phe Pro Ile Ser Asn Val Glu Leu Glu Lys Glu Met Gly Asp Lys Asp 
785                 790                 795                 800 


Lys Pro Leu Cys Leu Phe Gln Ile Ser Asn Lys Asp Leu Ser Phe Ala 
                805                 810                 815     


Lys Thr Phe Ser Ala Asn Leu Arg Lys Lys Arg Gly Ala Glu Asn Leu 
            820                 825                 830         


His Thr Met Leu Phe Lys Ala Leu Met Glu Gly Asn Gln Asp Asn Leu 
        835                 840                 845             


Asp Leu Gly Ser Gly Ala Ile Phe Tyr Arg Ala Lys Ser Leu Asp Gly 
    850                 855                 860                 


Asn Lys Pro Thr His Pro Ala Asn Glu Ala Ile Lys Cys Arg Asn Val 
865                 870                 875                 880 


Ala Asn Lys Asp Lys Val Ser Leu Phe Thr Tyr Asp Ile Tyr Lys Asn 
                885                 890                 895     


Arg Arg Tyr Met Glu Asn Lys Phe Leu Phe His Leu Ser Ile Val Gln 
            900                 905                 910         


Asn Tyr Lys Ala Ala Asn Asp Ser Ala Gln Leu Asn Ser Ser Ala Thr 
        915                 920                 925             


Glu Tyr Ile Arg Lys Ala Asp Asp Leu His Ile Ile Gly Ile Asp Arg 
    930                 935                 940                 


Gly Glu Arg Asn Leu Leu Tyr Tyr Ser Val Ile Asp Met Lys Gly Asn 
945                 950                 955                 960 


Ile Val Glu Gln Asp Ser Leu Asn Ile Ile Arg Asn Asn Asp Leu Glu 
                965                 970                 975     


Thr Asp Tyr His Asp Leu Leu Asp Lys Arg Glu Lys Glu Arg Lys Ala 
            980                 985                 990         


Asn Arg Gln Asn Trp Glu Ala Val  Glu Gly Ile Lys Asp  Leu Lys Lys 
        995                 1000                 1005             


Gly Tyr  Leu Ser Gln Ala Val  His Gln Ile Ala Gln  Leu Met Leu 
    1010                 1015                 1020             


Lys Tyr  Asn Ala Ile Ile Ala  Leu Glu Asp Leu Gly  Gln Met Phe 
    1025                 1030                 1035             


Val Thr  Arg Gly Gln Lys Ile  Glu Lys Ala Val Tyr  Gln Gln Phe 
    1040                 1045                 1050             


Glu Lys  Ser Leu Val Asp Lys  Leu Ser Tyr Leu Val  Asp Lys Lys 
    1055                 1060                 1065             


Arg Pro  Tyr Asn Glu Leu Gly  Gly Ile Leu Lys Ala  Tyr Gln Leu 
    1070                 1075                 1080             


Ala Ser  Ser Ile Thr Lys Asn  Asn Ser Asp Lys Gln  Asn Gly Phe 
    1085                 1090                 1095             


Leu Phe  Tyr Val Pro Ala Trp  Asn Thr Ser Lys Ile  Asp Pro Val 
    1100                 1105                 1110             


Thr Gly  Phe Thr Asp Leu Leu  Arg Pro Lys Ala Met  Thr Ile Lys 
    1115                 1120                 1125             


Glu Ala  Gln Asp Phe Phe Gly  Ala Phe Asp Asn Ile  Ser Tyr Asn 
    1130                 1135                 1140             


Asp Lys  Gly Tyr Phe Glu Phe  Glu Thr Asn Tyr Asp  Lys Phe Lys 
    1145                 1150                 1155             


Ile Arg  Met Lys Ser Ala Gln  Thr Arg Trp Thr Ile  Cys Thr Phe 
    1160                 1165                 1170             


Gly Asn  Arg Ile Lys Arg Lys  Lys Asp Lys Asn Tyr  Trp Asn Tyr 
    1175                 1180                 1185             


Glu Glu  Val Glu Leu Thr Glu  Glu Phe Lys Lys Leu  Phe Lys Asp 
    1190                 1195                 1200             


Ser Asn  Ile Asp Tyr Glu Asn  Cys Asn Leu Lys Glu  Glu Ile Gln 
    1205                 1210                 1215             


Asn Lys  Asp Asn Arg Lys Phe  Phe Asp Asp Leu Ile  Lys Leu Leu 
    1220                 1225                 1230             


Gln Leu  Thr Leu Gln Met Arg  Asn Ser Asp Asp Lys  Gly Asn Asp 
    1235                 1240                 1245             


Tyr Ile  Ile Ser Pro Val Ala  Asn Ala Glu Gly Gln  Phe Phe Asp 
    1250                 1255                 1260             


Ser Arg  Asn Gly Asp Lys Lys  Leu Pro Leu Asp Ala  Asp Ala Asn 
    1265                 1270                 1275             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu Trp Asn  Ile Arg Gln 
    1280                 1285                 1290             


Ile Lys  Gln Thr Lys Asn Asp  Lys Lys Leu Asn Leu  Ser Ile Ser 
    1295                 1300                 1305             


Ser Thr  Glu Trp Leu Asp Phe  Val Arg Glu Lys Pro  Tyr Leu Lys 
    1310                 1315                 1320             


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD34 CDRL1

<400>  139

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD34 CDRL2

<400>  140

Gln Val Ser Asn Arg Phe Ser 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD34 CDRL3

<400>  141

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD34 CDRH1

<400>  142

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD34 CDRH2

<400>  143

Trp Ile Asn Thr Asn Thr Gly Glu Pro Lys Tyr Ala Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD34 CDRH3

<400>  144

Gly Tyr Gly Asn Tyr Ala Arg Gly Ala Trp Leu Ala Tyr 
1               5                   10              


<210>  145
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-cD90 scFv

<400>  145

Cys Met Ala Ser Ala Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25                  30          


Tyr Thr Phe Thr Gly Tyr Tyr Val His Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Val Asn Pro Asn Ser Gly Asp Thr 
    50                  55                  60                  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Gly Leu Arg Ser Asp Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Asp Glu Asp Trp Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Pro Val Thr Val Ser Ser Gly Ile Leu 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg 
                165                 170                 175     


Ser Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu 
            180                 185                 190         


Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro 
225                 230                 235                 240 


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ser Gly Ile Pro 
                245                 250                 255     


Glu Gln Lys Leu 
            260 


<210>  146
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 variable light chain

<400>  146

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Ser Leu Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  147
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 variable heavy chain

<400>  147

Glu Ile Gln Leu Gln Gln Ser Gly Pro Asp Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val His Trp Val Lys Gln Ser Leu Asp Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Asp Phe Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Asp Trp Tyr Asp Thr Ser Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Ala Val 
        115                 120 


<210>  148
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 CDRL1

<400>  148

Gln Ser Ser Gln Ser Val Tyr Asn Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 CDRL2

<400>  149

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 CDRL3

<400>  150

Gln Gly Glu Phe Ser Cys Asp Ser Ala Asp Cys Ala Ala 
1               5                   10              


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 CDRH1

<400>  151

Gly Ile Asp Leu Asn Asn Tyr 
1               5           


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD133 CDRH2

<400>  152

Phe Gly Ser Asp Ser 
1               5   


<210>  153
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  153
cccuccuaca uaggg                                                        15


<210>  154
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  154
gagacaagaa uaaacgcuca acccacccuc cuacauaggg aggaacgagu uacuauagag       60

cuucgacagg aggcucacaa c                                                 81


<210>  155
<211>  58
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  155
gagacaagaa uaaacgcuca acccacccuc cuacauaggg aggaacgagu uacuauag         58


<210>  156
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  156
ccacccuccu acauagggug g                                                 21


<210>  157
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  157
cagaacguau acuauucug                                                    19


<210>  158
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  158
agaacguaua cuauu                                                        15


<210>  159
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence binding CD133

<400>  159
gagacaagaa uaaacgcuca aggaaagcgc uuauuguuug cuauguuaga acguauacua       60

uuucgacagg aggcucacaa caggc                                             85


<210>  160
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  160

Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala Thr Leu 
1               5                   10                  15      


Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr 
            20                  25                  30          


Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln Gly Val 
        35                  40                  45              


Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val Arg Phe 
    50                  55                  60                  


Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro Val Val 
65                  70                  75                  80  


Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg Arg Ser 
                85                  90                  95      


Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp Asp 
            100                 105                 110         


Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
        115                 120                 125             


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
    130                 135                 140                 


Gln 
145 


<210>  161
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variable light chain

<400>  161

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  162
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variable heavy chain

<400>  162

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  163
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variable heavy chain

<400>  163

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL1

<400>  164

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL2

<400>  165

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL3

<400>  166

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  167
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH1

<400>  167

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  168
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH2

<400>  168

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  169
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH3

<400>  169

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL1

<400>  170

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL3

<400>  171

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  172
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH1

<400>  172

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH2

<400>  173

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  174
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH3

<400>  174

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL1

<400>  175

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  176
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH1

<400>  176

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH2

<400>  177

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  178
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH3

<400>  178

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL1

<400>  179

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH2

<400>  180

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  181
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH3

<400>  181

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  182
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL1

<400>  182

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRL3

<400>  183

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  184
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH1

<400>  184

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH2

<400>  185

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  186
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 CDRH3

<400>  186

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  187
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 variable light chain

<400>  187

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  188
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 variable heavy chain

<400>  188

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  189
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 CDRL1

<400>  189

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  190
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 CDRL2

<400>  190

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 CDRL3

<400>  191

Gln Gln Tyr Tyr Ser Tyr Arg Thr 
1               5               


<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 CDRH1

<400>  192

Gly Tyr Thr Phe Thr Ser Tyr Val Ile His 
1               5                   10  


<210>  193
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 CDRH2

<400>  193

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  194
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD4 CDRH3

<400>  194

Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr 
1               5                   10              


<210>  195
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 variable heavy chain

<400>  195

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  196
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 variable light chain

<400>  196

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRL1

<400>  197

His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
1               5                   10      


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRL2

<400>  198

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRL3

<400>  199

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH1

<400>  200

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  201
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH2

<400>  201

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys 
1               5                   10                  


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH3

<400>  202

Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
1               5                   10      


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH1

<400>  203

Ser Tyr Tyr Ile His 
1               5   


<210>  204
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH2

<400>  204

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL1

<400>  205

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  206
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL2

<400>  206

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL3

<400>  207

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  208
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH1

<400>  208

Tyr Tyr Trp Ser 
1               


<210>  209
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH3

<400>  209

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL1

<400>  210

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL2

<400>  211

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  212
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL3

<400>  212

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH1

<400>  213

Gly Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   10  


<210>  214
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  214
tatttgcatt gagatagtgt ggg                                               23


<210>  215
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  215
atatttgcat tgagatagtg tgg                                               23


<210>  216
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  216
atgcaaatat ctgtctgaaa cgg                                               23


<210>  217
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  217
tatctgtctg aaacggtccc tgg                                               23


<210>  218
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  218
gctattggtc aaggcaaggc tgg                                               23


<210>  219
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  219
caaggctatt ggtcaaggca agg                                               23


<210>  220
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  220
cttgtcaagg ctattggtca agg                                               23


<210>  221
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  221
cttgaccaat agccttgaca agg                                               23


<210>  222
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  222
gtttgccttg tcaaggctat tgg                                               23


<210>  223
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 guide

<400>  223
tggtcaagtt tgccttgtca agg                                               23


<210>  224
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 guide

<400>  224
tttcagacag atatttgcat tgaga                                             25


<210>  225
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  225
guguccccgu uuugguuggu aaac                                              24


<210>  226
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  226
aaaaaucaau accgauaaua auga                                              24


<210>  227
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  227
cuuaauauga auauuaauau cggu                                              24


<210>  228
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  228
ccguaucugg aaggggcauc uugg                                              24


<210>  229
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  229
ccuuaggacc ggaaggauua cagc                                              24


<210>  230
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  230
gccuaaaagg cacuauguca aaug                                              24


<210>  231
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  231
ggagcuguug gcaucauguu ccug                                              24


<210>  232
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  232
gauucuuuuc uaucucagga caga                                              24


<210>  233
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  233
auagacaucc cacacuguag uucu                                              24


<210>  234
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  234
auuaauuuga gaaccaacau aagg                                              24


<210>  235
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  235
auuuucuuuu ugguaagaag gaac                                              24


<210>  236
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  236
cacacacaca cacacacaca caca                                              24


<210>  237
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  237
auccaaaccu ccuaaaugau ac                                                22


<210>  238
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  238
acacccgauc cacuggggag ca                                                22


<210>  239
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  239
uugauucuuu ucuaucucag gaca                                              24


<210>  240
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  240
ncacccgauc cacuggggag ca                                                22


<210>  241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  241
cacccgaucc acuggggagc                                                   20


<210>  242
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  242
nccuugucaa ggcuauuggu ca                                                22


<210>  243
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  243
ccuugucaag gcuauugguc a                                                 21


<210>  244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  244
guggggaagg ggcccccaag                                                   20


<210>  245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  245
auugagauag uguggggaag                                                   20


<210>  246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  246
cauugagaua guguggggaa                                                   20


<210>  247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  247
gcauugagau agugugggga                                                   20


<210>  248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  248
auuugcauug agauagugug                                                   20


<210>  249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  249
uauuugcauu gagauagugu                                                   20


<210>  250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  250
auauuugcau ugagauagug                                                   20


<210>  251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  251
augcaaauau cugucugaaa                                                   20


<210>  252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  252
uaucugucug aaacgguccc                                                   20


<210>  253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  253
gcuauugguc aaggcaaggc                                                   20


<210>  254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  254
caaggcuauu ggucaaggca                                                   20


<210>  255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  255
cuugucaagg cuauugguca                                                   20


<210>  256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  256
cuugaccaau agccuugaca                                                   20


<210>  257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  257
guuugccuug ucaaggcuau                                                   20


<210>  258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  258
uggucaaguu ugccuuguca                                                   20


<210>  259
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  259
gcauugagau agugugggga ag                                                22


<210>  260
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  260
cagacagaua uuugcauuga ga                                                22


<210>  261
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  261
agccagggac cguuucagac ag                                                22


<210>  262
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription of DNA target site

<400>  262
gccuugucaa ggcuauuggu ca                                                22


<210>  263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA transcribed from DNA target site

<400>  263
cacccgaucc acuggggagc                                                   20


<210>  264
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA transcribed from DNA target site

<400>  264
ccuugucagg gcuguugguc g                                                 21


