                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  MUC4 CAR-T CELLS FOR TREATING CANCER

<130>  01001/007229-WO0

<140>  PCT/US19/65276
<141>  2019-12-09

<150>  62/776,847
<151>  2018-12-07

<150>  62/902,451
<151>  2019-09-19

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  339
<212>  DNA
<213>  mouse

<400>  1
gatgttttga tgacccaaac tccactcact ttgtcggttg ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagtctctta gataagagtg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccgaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      300

ctcacgttcg gtgctgggac caagctggaa ataaaacgg                             339


<210>  2
<211>  348
<212>  DNA
<213>  mouse

<400>  2
gaggtgcagc tgcagcagtc aggacctgaa ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcagt agctatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attattcctt acaatgatga tattaagtac      180

agtgagaagc ttaaaggcaa ggccacactg acttcagaca aatcctccaa cacagcctac      240

gtggagctca gcagcctgac ctctgaggac tctggggtct attactgtgc aatttttggt      300

aactacgtga gttattgggg ccaagggacc acggtcaccg tctcctca                   348


<210>  3
<211>  657
<212>  DNA
<213>  Homo sapiens

<400>  3
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc       60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      120

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc      180

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      240

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc      300

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      360

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat      420

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac      480

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag      540

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc      600

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc         657


<210>  4
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  4
ctatcaattt ttgatcctcc tccttttaaa gtaactctta caggaggata tttgcatatt       60

tatgaatcac aactttgttg ccagctgaag ttctggttac ccataggatg tgcagccttt      120

gttgtagtct gcattttggg atgcatactt atttgttggc ttacaaaaaa gaagtattca      180

tccagtgtgc acgaccctaa cggtgaatac atgttcatga gagcagtgaa cacagccaaa      240

aaatctagac tcacagatgt gaccctaaga gtgaagttca gcaggagcgc agacgccccc      300

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      360

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg      420

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac      480

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag      540

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct      600

cgc                                                                    603


<210>  5
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  5
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc       60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      120

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc      180

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgttc      240

atgagagcag tgaacacagc caaaaaatct agactcacag atgtgaccct aagagtgaag      300

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      360

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      420

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      480

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc      540

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc      600

cttcacatgc aggccctgcc ccctcgc                                          627


<210>  6
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  7
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Ser Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly 
1               5                   10                  15      


Tyr Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp 
            20                  25                  30          


Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys 
        35                  40                  45              


Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His 
    50                  55                  60                  


Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys 
65                  70                  75                  80  


Lys Ser Arg Leu Thr Asp Val Thr Leu 
                85                  


<210>  8
<211>  97
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  8

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Phe 
65                  70                  75                  80  


Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
                85                  90                  95      


Leu 
    


<210>  9
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  10
<211>  695
<212>  DNA
<213>  Homo sapiens

<400>  10
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      300

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc      360

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      420

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      480

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      540

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac      600

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc      660

cctcgctaac gcccctctcc ctcccccccc cctaa                                 695


<210>  11
<211>  641
<212>  DNA
<213>  Homo sapiens

<400>  11
gcggccgcac tatcaatttt tgatcctcct ccttttaaag taactcttac aggaggatat       60

ttgcatattt atgaatcaca actttgttgc cagctgaagt tctggttacc cataggatgt      120

gcagcctttg ttgtagtctg cattttggga tgcatactta tttgttggct tacaaaaaag      180

aagtattcat ccagtgtgca cgaccctaac ggtgaataca tgttcatgag agcagtgaac      240

acagccaaaa aatctagact cacagatgtg accctaagag tgaagttcag caggagcgca      300

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga      360

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag      420

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      480

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc      540

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc      600

ctgccccctc gctaacgccc ctctccctcc ccccccccta a                          641


<210>  12
<211>  665
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  12
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgttca tgagagcagt gaacacagcc aaaaaatcta gactcacaga tgtgacccta      300

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      360

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      420

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      480

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      540

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      600

tacgacgccc ttcacatgca ggccctgccc cctcgctaac gcccctctcc ctcccccccc      660

cctaa                                                                  665


<210>  13
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  14
<211>  9211
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  14
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg gccgcgctga tcttcagacc tggaggagga     1560

gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca     1620

ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg     1680

ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg     1740

tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac     1800

aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc     1860

aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg     1920

gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt     1980

tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga     2040

gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa     2100

gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt     2160

aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta     2220

ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca     2280

ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata     2340

gaagaagaag gtggagagag agacagagac agatccattc gattagtgaa cggatcggca     2400

ctgcgtgcgc caattctgca gacaaatggc agtattcatc cacaatttta aaagaaaagg     2460

ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca     2520

aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt attacaggga     2580

cagcagagat ccagtttggt tagtaccggg cccgctctag ccgtgaggct ccggtgcccg     2640

tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa     2700

ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg     2760

gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa     2820

cgttcttttt cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg     2880

cgggcctggc ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct     2940

gcagtacgtg attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc     3000

ttgcgcttaa ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg     3060

ccgccgcgtg cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct     3120

agccatttaa aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt     3180

aaatgcgggc caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg     3240

ggcccgtgcg tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag     3300

aatcggacgg gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc     3360

gtgtatcgcc ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga     3420

aagatggccg cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg     3480

agagcgggcg ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc     3540

ttcatgtgac tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt     3600

ttggagtacg tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac     3660

tgagtgggtg gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt     3720

tgcccttttt gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt     3780

ttttcttcca tttcaggtgt cgtgagcggc cgctgaactg gccaccatgt ggctgcagtc     3840

tctgctgctg ctgggcaccg tggcctgtag catcagcgat gttttgatga cccaaactcc     3900

actcactttg tcggttgcca ttggacaacc agcctccatc tcttgcaagt caagtcagag     3960

tctcttagat aagagtggaa agacatattt gaattggttg ttacagaggc caggccagtc     4020

tccgaagcgc ctaatctatc tggtgtctaa actggactct ggagtccctg acaggttcac     4080

tggcagtgga tcagggacag atttcacact gaaaatcagc agagtggagg ctgaggattt     4140

gggagtttat tattgctggc aaggtacaca ttttccgctc acgttcggtg ctgggaccaa     4200

gctggaaata aaacggggca gcacaagcgg cagcggaaag cctggatctg gcgagggctc     4260

taccaaggga gaggtgcagc tgcagcagtc aggacctgaa ctggtaaagc ctggggcttc     4320

agtgaagatg tcctgcaagg cttctggata cacattcagt agctatgtta tgcactgggt     4380

gaagcagaag cctgggcagg gccttgagtg gattggatat attattcctt acaatgatga     4440

tattaagtac agtgagaagc ttaaaggcaa ggccacactg acttcagaca aatcctccaa     4500

cacagcctac gtggagctca gcagcctgac ctctgaggac tctggggtct attactgtgc     4560

aatttttggt aactacgtga gttattgggg ccaagggacc acggtcaccg tctcctcagc     4620

cctgagcaac agcatcatgt acttcagcca cttcgtgccc gtgtttctgc ccgccaagcc     4680

taccacaacc cctgccccta gacctcctac cccagcccct acaatcgcca gccagcctct     4740

gtctctgagg cccgaggctt ctagaccagc tgctggcgga gccgtgcaca ccagaggact     4800

ggacaagccc ttctgggtgc tggtggtcgt gggcggagtg ctggcctgtt acagcctgct     4860

cgtgacagtg gccttcatca tcttttgggt gcgcagcaag cggtctagac tgctgcacag     4920

cgactacatg aacatgaccc ccagaaggcc aggccccacc cggaagcact atcagcctta     4980

cgcccctccc agagacttcg ccgcctaccg gtccagagtg aagttcagca gaagcgccga     5040

cgcccctgcc tatcagcagg gccagaacca gctgtacaac gagctgaacc tgggcagacg     5100

ggaagagtac gacgtgctgg acaagagaag aggccgggac cctgagatgg gcggcaagcc     5160

cagacggaag aaccctcagg aaggcctgta taacgaactg cagaaagaca agatggccga     5220

ggcctactcc gagatcggca tgaagggcga acggcggaga ggcaagggac acgatggact     5280

gtaccagggc ctgagcaccg ccaccaagga cacctatgac gccctgcaca tgcaggccct     5340

gccccccaga tgaaattcat cgacgttaac tattctagag tacccgggct aggatccgcc     5400

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     5460

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     5520

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     5580

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     5640

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     5700

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     5760

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     5820

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca     5880

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     5940

acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggc ccagtccaag     6000

cacggcctga ccaaggagat gaccatgaag taccgcatgg agggctgcgt ggacggccac     6060

aagttcgtga tcaccggcga gggcatcggc taccccttca agggcaagca ggccatcaac     6120

ctgtgcgtgg tggagggcgg ccccttgccc ttcgccgagg acatcttgtc cgccgccttc     6180

atgtacggca accgcgtgtt caccgagtac ccccaggaca tcgtcgacta cttcaagaac     6240

tcctgccccg ccggctacac ctgggaccgc tccttcctgt tcgaggacgg cgccgtgtgc     6300

atctgcaacg ccgacatcac cgtgagcgtg gaggagaact gcatgtacca cgagtccaag     6360

ttctacggcg tgaacttccc cgccgacggc cccgtgatga agaagatgac cgacaactgg     6420

gagccctcct gcgagaagat catccccgtg cccaagcagg gcatcttgaa gggcgacgtg     6480

agcatgtacc tgctgctgaa ggacggtggc cgcttgcgct gccagttcga caccgtgtac     6540

aaggccaagt ccgtgccccg caagatgccc gactggcact tcatccagca caagctgacc     6600

cgcgaggacc gcagcgacgc caagaaccag aagtggcacc tgaccgagca cgccatcgcc     6660

tccggctccg ccttgcccta aggatcgcat cgataccgtc gacctcgatc gagacctaga     6720

aaaacatgga gcaatcacaa gtagcaatac agcagctacc aatgctgatt gtgcctggct     6780

agaagcacaa gaggaggagg aggtgggttt tccagtcaca cctcaggtac ctttaagacc     6840

aatgacttac aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga     6900

agggctaatt cactcccaac gaagacaaga tatccttgat ctgtggatct accacacaca     6960

aggctacttc cctgattggc agaactacac accagggcca gggatcagat atccactgac     7020

ctttggatgg tgctacaagc tagtaccagt tgagcaagag aaggtagaag aagccaatga     7080

aggagagaac acccgcttgt tacaccctgt gagcctgcat gggatggatg acccggagag     7140

agaagtatta gagtggaggt ttgacagccg cctagcattt catcacatgg cccgagagct     7200

gcatccggac tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg     7260

ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt     7320

gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt     7380

gtggaaaatc tctagcagca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     7440

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     7500

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     7560

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     7620

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     7680

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     7740

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     7800

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     7860

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     7920

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     7980

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     8040

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     8100

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     8160

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     8220

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     8280

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     8340

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     8400

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     8460

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     8520

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     8580

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     8640

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     8700

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     8760

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     8820

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat     8880

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     8940

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt     9000

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     9060

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     9120

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     9180

gcgcacattt ccccgaaaag tgccacctga c                                    9211


<210>  15
<211>  508
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  15

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile 
            20                  25                  30          


Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp 
        35                  40                  45              


Lys Ser Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
                85                  90                  95      


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln 
            100                 105                 110         


Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Ser Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Tyr Ile Ile Pro Tyr Asn Asp Asp Ile Lys Tyr 
        195                 200                 205             


Ser Glu Lys Leu Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
    210                 215                 220                 


Asn Thr Ala Tyr Val Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Gly 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ile Phe Gly Asn Tyr Val Ser Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr 
            260                 265                 270         


Phe Ser His Pro Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Lys Pro Phe Trp Val Leu Val Val Val Gly 
                325                 330                 335     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            340                 345                 350         


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        355                 360                 365             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    370                 375                 380                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  16
<211>  1565
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  16
gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg caccgtggcc       60

tgtagcatca gcgatgtttt gatgacccaa actccactca ctttgtcggt tgccattgga      120

caaccagcct ccatctcttg caagtcaagt cagagtctct tagataagag tggaaagaca      180

tatttgaatt ggttgttaca gaggccaggc cagtctccga agcgcctaat ctatctggtg      240

tctaaactgg actctggagt ccctgacagg ttcactggca gtggatcagg gacagatttc      300

acactgaaaa tcagcagagt ggaggctgag gatttgggag tttattattg ctggcaaggt      360

acacattttc cgctcacgtt cggtgctggg accaagctgg aaataaaacg gggcagcaca      420

agcggcagcg gaaagcctgg atctggcgag ggctctacca agggagaggt gcagctgcag      480

cagtcaggac ctgaactggt aaagcctggg gcttcagtga agatgtcctg caaggcttct      540

ggatacacat tcagtagcta tgttatgcac tgggtgaagc agaagcctgg gcagggcctt      600

gagtggattg gatatattat tccttacaat gatgatatta agtacagtga gaagcttaaa      660

ggcaaggcca cactgacttc agacaaatcc tccaacacag cctacgtgga gctcagcagc      720

ctgacctctg aggactctgg ggtctattac tgtgcaattt ttggtaacta cgtgagttat      780

tggggccaag ggaccacggt caccgtctcc tcagccctga gcaacagcat catgtacttc      840

agccacttcg tgcccgtgtt tctgcccgcc aagcctacca caacccctgc ccctagacct      900

cctaccccag cccctacaat cgccagccag cctctgtctc tgaggcccga ggcttctaga      960

ccagctgctg gcggagccgt gcacaccaga ggcctggaca agcccttctg ggtgctggtg     1020

gtcgtgggcg gagtgctggc ctgttacagc ctgctcgtga cagtggcctt catcatcttt     1080

tgggtgcgca gcaagcggtc tagactgctg cacagcgact acatgaacat gacccccaga     1140

aggccaggcc ccacccggaa gcactatcag ccttacgccc ctcccagaga cttcgccgcc     1200

taccggtcca gagtgaagtt cagcagaagc gccgacgccc ctgcctatca gcagggccag     1260

aaccagctgt acaacgagct gaacctgggc agacgggaag agtacgacgt gctggacaag     1320

cggagaggca gggaccctga gatgggcggc aagcccagac ggaagaaccc tcaggaaggc     1380

ctgtataacg aactgcagaa agacaagatg gccgaggcct actccgagat cggaatgaag     1440

ggcgagcgga gaagaggcaa gggccacgat ggactgtacc agggcctgag caccgccacc     1500

aaggacacct atgacgccct gcacatgcag gccctgcccc ccagatgaaa ttcatcgacg     1560

ttaac                                                                 1565


<210>  17
<211>  116
<212>  PRT
<213>  mouse

<400>  17

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ile Pro Tyr Asn Asp Asp Ile Lys Tyr Ser Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Phe Gly Asn Tyr Val Ser Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  18
<211>  117
<212>  PRT
<213>  mouse

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Ala Leu Gly Phe Asp Asn Trp Gly Arg Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  113
<212>  PRT
<213>  mouse

<400>  19

Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Lys 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  20
<211>  108
<212>  PRT
<213>  mouse

<400>  20

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Ala 
            100                 105             


<210>  21
<211>  899
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  21
gtcgtgagcg gccgctgaac tggccaccat gtggctgcag tctctgctgc tgctgggcac       60

cgtggcctgt agcatcagcg atgttttgat gacccaaact ccactcactt tgtcggttgc      120

cattggacaa ccagcctcca tctcttgcaa gtcaagtcag agtctcttag ataagagtgg      180

aaagacatat ttgaattggt tgttacagag gccaggccag tctccgaagc gcctaatcta      240

tctggtgtct aaactggact ctggagtccc tgacaggttc actggcagtg gatcagggac      300

agatttcaca ctgaaaatca gcagagtgga ggctgaggat ttgggagttt attattgctg      360

gcaaggtaca cattttccgc tcacgttcgg tgctgggacc aagctggaaa taaaacgggg      420

cagcacaagc ggcagcggaa agcctggatc tggcgagggc tctaccaagg gagaggtgca      480

gctgcagcag tcaggacctg aactggtaaa gcctggggct tcagtgaaga tgtcctgcaa      540

ggcttctgga tacacattca gtagctatgt tatgcactgg gtgaagcaga agcctgggca      600

gggccttgag tggattggat atattattcc ttacaatgat gatattaagt acagtgagaa      660

gcttaaaggc aaggccacac tgacttcaga caaatcctcc aacacagcct acgtggagct      720

cagcagcctg acctctgagg actctggggt ctattactgt gcaatttttg gtaactacgt      780

gagttattgg ggccaaggga ccacggtcac cgtctcctca gccctgagca acagcatcat      840

gtacttcagc cacttcgtgc ccgtgtttct gcccgccaag cctaccacaa cccctgccc       899


<210>  22
<211>  899
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (828)..(828)
<223>  n is a, c, g, or t

<400>  22
gtcgtgagcg gccgctgaac tggccaccat gtggctgcag tctctgctgc tgctggncac       60

cgtggcctgt agcatcagcg atgttttgat gacccaaact ccactcactt tgtcggttgc      120

cattggacaa ccagcctcca tctcttgcaa gtcaagtcag agtctcttag ataagagtgg      180

aaagacatat ttgaattggt tgttacagag gccaggccag tctccgaagc gcctaatcta      240

tctggtgtct aaactggact ctggagtccc tgacaggttc actggcagtg gatcagggac      300

agatttcaca ctgaaaatca gcagagtgga ggctgaggat ttgggagttt attattgctg      360

gcaaggtaca cattttccgc tcacgttcgg tgctgggacc aagctggaaa taaaacgggg      420

cagcacaagc ggcagcggaa agcctggatc tggcgagggc tctaccaagg gagaggtgca      480

gctgcagcag tcaggacctg aactggtaaa gcctggggct tcagtgaaga tgtcctgcaa      540

ggcttctgga tacacattca gtagctatgt tatgcactgg gtgaagcaga agcctgggca      600

gggccttgag tggattggat atattattcc ttacaatgat gatattaagt acagtgagaa      660

gcttaaaggc aaggccacac tgacttcaga caaatcctcc aacacagcct acgtggagct      720

cagcagcctg acctctgagg actctggggt ctattactgt gcaatttttg gtaactacgt      780

gagttattgg ggccaaggga ccacggtcac cgtctcctca gccctganca acagcatcat      840

gtacttcagc cacttcgtgc ccgtgtttct gcccgccaag cctaccacaa cccctgccc       899


<210>  23
<211>  798
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  23
gccacttcgt gcccgtgttt ctgcccgcca agcctaccac aacccctgcc cctagacctc       60

ctaccccagc ccctacaatc gccagccagc ctctgtctct gaggcccgag gcttctagac      120

cagctgctgg cggagccgtg cacaccagag gactggacaa gcccttctgg gtgctggtgg      180

tcgtgggcgg agtgctggcc tgttacagcc tgctcgtgac agtggccttc atcatctttt      240

gggtgcgcag caagcggtct agactgctgc acagcgacta catgaacatg acccccagaa      300

ggccaggccc cacccggaag cactatcagc cttacgcccc tcccagagac ttcgccgcct      360

accggtccag agtgaagttc agcagaagcg ccgacgcccc tgcctatcag cagggccaga      420

accagctgta caacgagctg aacctgggca gacgggaaga gtacgacgtg ctggacaaga      480

gaagaggccg ggaccctgag atgggcggca agcccagacg gaagaaccct caggaaggcc      540

tgtataacga actgcagaaa gacaagatgg ccgaggccta ctccgagatc ggcatgaagg      600

gcgaacggcg gagaggcaag ggacacgatg gactgtacca gggcctgagc accgccacca      660

aggacaccta tgacgccctg cacatgcagg ccctgccccc cagatgaaat tcatcgacgt      720

taactattct agagtacccg ggctaggatc cgcccctctc cctccccccc ccctaacgtt      780

actggccgaa gccgcttg                                                    798


<210>  24
<211>  798
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  24
gccncttcgt gcccgtgttt ctgcccgcca agcctaccac aacccctgcc cctagacctc       60

ctaccccagc ccctacaatc gccagccagc ctctgtctct gaggcccgag gcttctagac      120

cagctgctgg cggagccgtg cacaccagag gactggacaa gcccttctgg gtgctggtgg      180

tcgtgggcgg agtgctggcc tgttacagcc tgctcgtgac agtggccttc atcatctttt      240

gggtgcgcag caagcggtct agactgctgc acagcgacta catgaacatg acccccagaa      300

ggccaggccc cacccggaag cactatcagc cttacgcccc tcccagagac ttcgccgcct      360

accggtccag agtgaagttc agcagaagcg ccgacgcccc tgcctatcag cagggccaga      420

accagctgta caacgagctg aacctgggca gacgggaaga gtacgacgtg ctggacaaga      480

gaagaggccg ggaccctgag atgggcggca agcccagacg gaagaaccct caggaaggcc      540

tgtataacga actgcagaaa gacaagatgg ccgaggccta ctccgagatc ggcatgaagg      600

gcgaacggcg gagaggcaag ggacacgatg gactgtacca gggcctgagc accgccacca      660

aggacaccta tgacgccctg cacatgcagg ccctgccccc cagatgaaat tcatcgacgt      720

taactattct agagtacccg ggctaggatc cgcccctctc cctccccccc ccctaacgtt      780

actggccgaa gccgcttg                                                    798


