                         SEQUENCE LISTING

<110>  WuXi Biologics (Shanghai) CO., LTD. 
       WuXi Biologics Ireland Limited.
 
<120>  IEC196002PCT WBP3405

<130>  Anti-TIM-3 Antibodies and Uses Thereof

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 amino acid sequence

<400>  1

Gly Phe Thr Phe Ser Asn Tyr Ala Met Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 amino acid sequence

<400>  2

Ser Ile Ser Asp Asn Gly Gly Thr Ala Tyr His Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 amino acid sequence

<400>  3

Asp Phe Gly Asp Ser Pro Gly Tyr 
1               5               


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 amino acid sequence

<400>  4

Lys Ser Ser Gln Ser Val Leu Tyr Ser Phe Lys Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 amino acid sequence

<400>  5

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 amino acid sequence

<400>  6

Gln Gln Tyr Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 amino acid sequence

<400>  7

Ser Ile Ser Asp Gln Gly Gly Thr Ala Tyr His Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid sequence

<400>  8

Glu Val Gln Leu Leu Glu Ala Gly Gly Gly Pro Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Asp Asn Gly Gly Thr Ala Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Phe Gly Asp Ser Pro Gly Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucleic acid sequence

<400>  9
gaggtgcagt tgttggaggc tgggggaggc ccggtacagc ctggggggtc cctgagactc       60

tcctgtgcag ccgctggatt cacctttagc aactatgcca tgagctgggt ccggcaggct      120

ccagggaagg ggctggaatg ggtctcaagt attagtgaca atggtgggac cgcataccac      180

gcagactccg tgcagggccg attcaccatc tccagagaca attccaagag cacgctgtat      240

ctacaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagacttc      300

ggtgactccc cgggctactg gggccaggga accctggtca ccgtctcctc a               351


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL amino acid sequence

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Phe Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Val Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  11
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucleic acid sequence

<400>  11
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagcttca agaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctgt agatgtggca gtttattact gtcagcaata ttatagttct      300

ccgctcactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL amino acid sequence

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Phe Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  13
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucleic acid sequence

<400>  13
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagcttca agaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagttct      300

ccgctcactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid sequence

<400>  14

Glu Val Gln Leu Leu Glu Ala Gly Gly Gly Pro Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Asp Gln Gly Gly Thr Ala Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Phe Gly Asp Ser Pro Gly Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucleic acid sequence

<400>  15
gaggtgcagt tgttggaggc tgggggaggc ccggtacagc ctggggggtc cctgagactc       60

tcctgtgcag ccgctggatt cacctttagc aactatgcca tgagctgggt ccggcaggct      120

ccagggaagg ggctggaatg ggtctcaagt attagtgacc agggtgggac cgcataccac      180

gcagactccg tgcagggccg attcaccatc tccagagaca attccaagag cacgctgtat      240

ctacaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagacttc      300

ggtgactccc cgggctactg gggccaggga accctggtca ccgtctcctc a               351


