                         SEQUENCE LISTING

<110>  Enzymaster (Ningbo) Bio-Engineering Co., Ltd.
 
<120>  Engineered ketoreductase polypeptides and uses thereof

<130>  EMP059

<160>  332   

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  1
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  2
<211>  249
<212>  PRT
<213>  Chryseobacterium sp.CA49

<400>  2

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  3
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  3
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgcgct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  4
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  4

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Arg Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  5
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  5
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gtggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  6
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  6

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  7
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  7
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  8
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  8

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  9
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  9
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgtac ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  10
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  10

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Tyr Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  11
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  11
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcgc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  12
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  12

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Arg Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  13
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  13
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaacg cgcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  14
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  14

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Arg Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  15
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  15
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcatta ggggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  16
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  16

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Arg Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  17
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  17
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattc tgggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  18
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  18

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  19
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  19
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg ttggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  20
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  20

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Val Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  21
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  21
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattc agggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  22
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  22

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gln Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  23
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  23
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcatta agggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  24
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  24

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Lys Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  25
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  25
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgaag ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  26
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  26

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Lys Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  27
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  27
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgatgt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  28
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  28

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Met Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  29
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  29
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgttgt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  30
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  30

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Leu Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  31
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  31
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgcagt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  32
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  32

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Gln Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  33
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  33
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgtatagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  34
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  34

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Tyr Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  35
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  35
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  36
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  36

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  37
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  37
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  38
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  38

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  39
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  39
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  40
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  40

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  41
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  41
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcgtgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  42
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  42

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Val Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  43
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  43
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  44
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  44

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  45
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  45
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  46
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  46

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  47
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  47
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatcaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  48
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  48

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Ile Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  49
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  49
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  50
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  50

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  51
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  51
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  52
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  52

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  53
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  53
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  54
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  54

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  55
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  55
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  56
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  56

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  57
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  57
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  58
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  58

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  59
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  59
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  60
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  60

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  61
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  61
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  62
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  62

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  63
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  63
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  64
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  64

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  65
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  65
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  66
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  66

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  67
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  67
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  68
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  68

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  69
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  69
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  70
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  70

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  71
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  71
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  72
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  72

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  73
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  73
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  74
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  74

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  75
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  75
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  76
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  76

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  77
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  77
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatcaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  78
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  78

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Ile Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  79
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  79
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  80
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  80

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  81
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  81
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  82
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  82

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  83
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  83
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  84
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  84

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  85
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  85
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatcaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  86
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  86

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Ile Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  87
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  87
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  88
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  88

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  89
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  89
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  90
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  90

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  91
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  91
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatcaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  92
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  92

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Ile Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  93
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  93
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  94
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  94

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  95
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  95
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggcgcgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  96
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  96

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ala Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  97
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  97
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatcaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  98
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  98

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Ile Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  99
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  99
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  100
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  100

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  101
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  101
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  102
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  102

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  103
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  103
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcgtgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  104
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  104

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Val Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  105
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  105
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcgtgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  106
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  106

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Val Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  107
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  107
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagtggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct ggcgtccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  108
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  108

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Val Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  109
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  109
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggtagggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  110
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  110

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Arg 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  111
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  111
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgctaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  112
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  112

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  113
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  113
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  114
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  114

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  115
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  115
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atcgccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  116
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  116

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Ile Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  117
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  117
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggtaaggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  118
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  118

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Lys 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  119
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  119
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga ttgcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  120
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  120

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Cys Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  121
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  121
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga ttggaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  122
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  122

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Trp Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  123
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  123
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggtaacgg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaagcggt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatatcgc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgggcccggc ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  124
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  124

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Asn 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Ala Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Ile Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Gly Pro Ala Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  125
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  125
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgaag ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  126
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  126

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Lys Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  127
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  127
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgcgct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  128
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  128

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Arg Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  129
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  129
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  130
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  130

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  131
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  131
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcgc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  132
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  132

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Arg Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  133
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  133
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgaag ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  134
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  134

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Lys Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  135
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  135
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaacg cgcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgaac ccgctgcagt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  136
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  136

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Arg Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Asn Pro Leu Gln Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  137
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  137
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaacg cgcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgcagt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  138
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  138

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Arg Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Gln Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  139
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  139
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgcagt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  140
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  140

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Gln Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  141
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  141
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  142
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  142

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  143
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  143
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgcagt ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  144
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  144

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Gln Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  145
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  145
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgaag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  146
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  146

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Lys Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  147
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  147
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tggcgccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctcttac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  148
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  148

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Ala Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Ser Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  149
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  149
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tggcgccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcgattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  150
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  150

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Ala Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Asp Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  151
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  151
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tggcgccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcacttac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  152
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  152

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Ala Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Thr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  153
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  153
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tggcgccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcccgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  154
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  154

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Ala Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Pro Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  155
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  155
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacccgggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  156
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  156

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Pro Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  157
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  157
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tgtgaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  158
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  158

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Val Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  159
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  159
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  160
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  160

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  161
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  161
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaccggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  162
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  162

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Thr Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  163
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  163
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcagcgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  164
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  164

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Ser Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  165
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  165
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tcgcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  166
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  166

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Arg Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  167
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  167
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  168
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  168

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  169
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  169
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tcgcaacgaa      120

gacaccggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  170
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  170

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Arg Asn Glu Asp Thr Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  171
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  171
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tcgcaacgaa      120

gacagcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  172
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  172

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Arg Asn Glu Asp Ser Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  173
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  173
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcagcgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  174
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  174

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Ser Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  175
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  175
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

aacgccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  176
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  176

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Asn Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  177
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  177
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg cgtgggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  178
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  178

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Val Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  179
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  179
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atcgccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  180
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  180

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Ile Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  181
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  181
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaca ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

accgccagca ttcatggtat cgttgcggcc ccgctgagct ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  182
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  182

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Gln Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Thr Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Ala Pro Leu Ser Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  183
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  183
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tggcgccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  184
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  184

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Ala Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  185
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  185
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  186
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  186

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  187
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  187
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  188
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  188

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  189
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  189
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

aacgccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  190
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  190

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Asn Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  191
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  191
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcccgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  192
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  192

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Pro Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  193
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  193
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  194
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  194

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  195
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  195
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac taaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  196
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  196

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  197
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  197
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcccgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  198
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  198

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Pro Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  199
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  199
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

aacgccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  200
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  200

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Asn Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  201
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  201
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca tcagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc ttggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcccgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  202
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  202

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Ile 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Pro Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  203
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  203
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcccgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  204
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  204

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Pro Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  205
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  205
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  206
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  206

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  207
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  207
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  208
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  208

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  209
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  209
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  210
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  210

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  211
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  211
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  212
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  212

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  213
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  213
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccgcggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattc tgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggcccgtac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  214
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  214

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Arg Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Leu Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Pro Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  215
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  215
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  216
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  216

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  217
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  217
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccgcgaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  218
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  218

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ala Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  219
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  219
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta gcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  220
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  220

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ser Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  221
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  221
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccaccaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  222
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  222

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Thr Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  223
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  223
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg cgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  224
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  224

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Ala Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  225
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  225
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgatt atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  226
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  226

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Asp Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  227
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  227
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgatt atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg cgggctacac ggcagtg                                          747


<210>  228
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  228

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Asp Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Ala Gly Tyr Thr Ala Val 
                245                 


<210>  229
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  229
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaacatatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg agcggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgata ccggctacac ggcagtg                                          747


<210>  230
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  230

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys His Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Ser Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Thr Gly Tyr Thr Ala Val 
                245                 


<210>  231
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  231
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcgtgg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  232
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  232

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Val Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  233
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  233
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatc cgggctacac ggcagtg                                          747


<210>  234
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  234

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Pro Gly Tyr Thr Ala Val 
                245                 


<210>  235
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  235
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gaccatggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtcta tcaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgatt atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg aacggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  236
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  236

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp His Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Ile Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Asp Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Asn Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  237
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  237
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtcag       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  238
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  238

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Gln Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  239
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  239
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaagcc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  240
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  240

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Ala Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  241
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  241
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaaagccagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  242
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  242

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ser Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  243
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  243
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac gcgggaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  244
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  244

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Arg Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  245
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  245
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcccaga acggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  246
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  246

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Asn Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  247
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  247
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaacaccagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  248
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  248

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys His Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  249
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  249
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaaggccagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  250
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  250

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Gly Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  251
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  251
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaaac      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  252
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  252

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Asn 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  253
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  253
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaaag      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  254
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  254

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Lys 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  255
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  255
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattaca agctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  256
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  256

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Lys Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  257
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  257
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacc ggctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  258
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  258

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Arg Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  259
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  259
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacc cgctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  260
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  260

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Pro Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  261
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  261
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattaca ccctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  262
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  262

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Thr Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  263
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  263
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacc acctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  264
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  264

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr His Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  265
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  265
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaaca agggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  266
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  266

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Lys Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  267
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  267
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacc acggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  268
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  268

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn His Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  269
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  269
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaaca ccggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  270
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  270

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Thr Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  271
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  271
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacc gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  272
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  272

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Arg Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  273
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  273
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

gcgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  274
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  274

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Ala Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  275
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  275
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

gagaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  276
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  276

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Glu Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  277
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  277
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag acctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  278
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  278

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Asp Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  279
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  279
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaaa acctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  280
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  280

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Asn Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  281
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  281
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctggcctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  282
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  282

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ala Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  283
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  283
atgggtatcc tggacaacaa agtcgcagtg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  284
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  284

Met Gly Ile Leu Asp Asn Lys Val Ala Val Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  285
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  285
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcgtcggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  286
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  286

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Ser Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  287
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  287
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgcttcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  288
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  288

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Ala Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  289
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  289
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagtttttcg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  290
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  290

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Ser Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  291
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  291
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttatg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  292
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  292

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Met Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  293
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  293
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccatgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  294
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  294

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Met Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  295
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  295
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atgtctagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  296
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  296

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ser Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  297
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  297
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcaaccg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  298
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  298

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Thr Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  299
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  299
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaggcc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  300
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  300

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Arg Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  301
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  301
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc gagcgaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  302
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  302

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Ser Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  303
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  303
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgac accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  304
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  304

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Asp Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  305
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  305
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtga ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  306
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  306

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Ile Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  307
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  307
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgc tgggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  308
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  308

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Leu Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  309
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  309
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcga cttgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  310
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  310

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Thr Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  311
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  311
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgt cgctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  312
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  312

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Ser 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  313
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  313
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactga cgctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  314
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  314

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Thr 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  315
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  315
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aattttcgct ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  316
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  316

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Phe Ser Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  317
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  317
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatttgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  318
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  318

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Phe Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  319
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  319
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacacgct ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  320
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  320

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Thr Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  321
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  321
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcgtg      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  322
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  322

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Val Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  323
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  323
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgctct ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  324
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  324

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Ala Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  325
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  325
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatattctct ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  326
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  326

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Ser Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  327
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  327
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatttgttct ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgaat atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  328
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  328

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Phe Val Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Glu Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  329
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  329
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg cgggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgatt atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  330
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  330

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Ala Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Asp Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


<210>  331
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  331
atgggtatcc tggacaacaa agtcgcactg gttacgggcg ctggttcggg catcggtctg       60

gcggtggcac actcctacgc taaagaaggc gctaaagtca ttgtgtcaga tatcaacgaa      120

gacaagggta ataaaaccgt tgaagatatt aaagcacagg gcggtgaagc tagttttgtg      180

aaagcggaca ccagcaaccc ggaagaagtg gaagccctgg ttaaacgtac ggtcgaaatt      240

tatggtcgcc tggatgtggc atgcaacaat gctggcattg gcggtgaaaa ggcactggct      300

ggtgattacg gcctggacag ctggcgtaaa gttctgtctg tgaatctgga cggtgtcttc      360

tatggctgta aatacgaact ggaacaaatg gagaaaaacg gcggtggcgt tatcgtcaat      420

atggccagca ttcatggtat cgttgcgcag ccgctgaact ctgcatatac ctctgcgaaa      480

cacgccgtgg ttggcctgac gaaaaacatt ggtgctgatt atggccagaa aaacatccgt      540

tgcaatgcgg tgtgcccggg ctacattgaa accccgctgc tggaatcact gacgaaagaa      600

atgaaagaag ccctgatctc gaaacacccg atgggtcgcc tgggcaaacc ggaagaagtg      660

gcagaactgg ttctgtttct gagttccgaa aaatcatcgt tcatgaccgg tggctattac      720

ctggtcgatg gtggctacac ggcagtg                                          747


<210>  332
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  332

Met Gly Ile Leu Asp Asn Lys Val Ala Leu Val Thr Gly Ala Gly Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Val Ala His Ser Tyr Ala Lys Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Val Ser Asp Ile Asn Glu Asp Lys Gly Asn Lys Thr Val Glu 
        35                  40                  45              


Asp Ile Lys Ala Gln Gly Gly Glu Ala Ser Phe Val Lys Ala Asp Thr 
    50                  55                  60                  


Ser Asn Pro Glu Glu Val Glu Ala Leu Val Lys Arg Thr Val Glu Ile 
65                  70                  75                  80  


Tyr Gly Arg Leu Asp Val Ala Cys Asn Asn Ala Gly Ile Gly Gly Glu 
                85                  90                  95      


Lys Ala Leu Ala Gly Asp Tyr Gly Leu Asp Ser Trp Arg Lys Val Leu 
            100                 105                 110         


Ser Val Asn Leu Asp Gly Val Phe Tyr Gly Cys Lys Tyr Glu Leu Glu 
        115                 120                 125             


Gln Met Glu Lys Asn Gly Gly Gly Val Ile Val Asn Met Ala Ser Ile 
    130                 135                 140                 


His Gly Ile Val Ala Gln Pro Leu Asn Ser Ala Tyr Thr Ser Ala Lys 
145                 150                 155                 160 


His Ala Val Val Gly Leu Thr Lys Asn Ile Gly Ala Asp Tyr Gly Gln 
                165                 170                 175     


Lys Asn Ile Arg Cys Asn Ala Val Cys Pro Gly Tyr Ile Glu Thr Pro 
            180                 185                 190         


Leu Leu Glu Ser Leu Thr Lys Glu Met Lys Glu Ala Leu Ile Ser Lys 
        195                 200                 205             


His Pro Met Gly Arg Leu Gly Lys Pro Glu Glu Val Ala Glu Leu Val 
    210                 215                 220                 


Leu Phe Leu Ser Ser Glu Lys Ser Ser Phe Met Thr Gly Gly Tyr Tyr 
225                 230                 235                 240 


Leu Val Asp Gly Gly Tyr Thr Ala Val 
                245                 


