                         SEQUENCE LISTING

<110>  WUXI BIOLOGICS (SHANGHAI) CO., LTD.
       WUXI BIOLOGICS IRELAND LIMITED
 
<120>  HUMANIZED ANTIBODIES AGAINST OX40, METHOD FOR PREPARING THE SAME, AND USE THEREOF

<130>  IEC196007PCT

<150>  PCT/CN2018/121266
<151>  2018-12-14

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1 amino acid sequence

<400>  1

Gly Tyr Thr Ile Thr Arg Gly Ser Asp Trp Ser 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1 amino acid sequence

<400>  2

Gln Ser Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
1               5                   10      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 amino acid sequence

<400>  3

Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2 amino acid sequence

<400>  4

Gly Ala Asn Ser Leu Gln Ser 
1               5           


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3 amino acid sequence

<400>  5

Ser Asp Tyr Ser Pro Tyr Val Met Leu Ala 
1               5                   10  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3 amino acid sequence

<400>  6

Gln Gln Gly Leu Arg Ser Pro Phe Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid sequence

<400>  7

Glu Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Arg Gly 
            20                  25                  30          


Ser Asp Trp Ser Trp Ile Arg Lys Phe Pro Gly Asn Ile Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ser Glu Asp Ser Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Ser Pro Tyr Val Met Leu Ala Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL amino acid sequence

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Gln Cys Gln Ser Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Phe His Gln Lys Pro Gly Arg Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Asn Ile His Ser 
65                  70                  75                  80  


Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Arg Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid sequence

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Arg Gly 
            20                  25                  30          


Ser Asp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Ser Pro Tyr Val Met Leu Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL amino acid sequence

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Arg Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucleotide sequence

<400>  11
gagatacagc tgcaggagtc aggacctggc cttgtgaaac cttcacagtc actctccctc       60

acctgttctg tcactggtta caccatcacc agaggttctg attggagctg gatccggaag      120

ttcccaggaa atataatgga gtggatggga tacataagcc acagtggtag cacttcctac      180

aacccatcgc tcagaagtcg aatctccatt acacgagaca cgtccaagaa tcagttcttc      240

ctgcagttga actctgtaac ttctgaggat tcagccactt attactgtgc aagatcagac      300

tacagtcctt atgttatgct tgcctggggt caaggagctt cagtcactgt ctcctca         357


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucleotide sequence

<400>  12
gacatccaga tgacacagtc tccaacttcc ctatctgcat ctctgggaga aactgtcacc       60

atccaatgtc aatcaagtga ggacatttat agtggtttag cgtggtttca ccagaagcca      120

gggagatctc ctcaactcct gatctatggt gcgaatagtt tgcaatctgg ggtcccatct      180

cggttcagtg gcagtggatc tggcacacag tattctctca agatcagcaa catacattct      240

gaagatgaag gagtttattt ctgtcaacag ggattaaggt ctccgttcac gtttggagct      300

gggaccaagt tggaactgaa a                                                321


<210>  13
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucleotide sequence

<400>  13
caggtgcagc tgcaggaatc cggccccgga ctggtgaagc ctagcgagac cctgagcctg       60

acctgtagcg tgaccggcta caccatcacc aggggcagcg actggagctg gatcaggcag      120

ccccccggaa agggactgga gtggatcggc tacatcagcc acagcggcag caccagctac      180

aacccctccc tgaggagcag ggtgaccatc agcgtggaca ccagcaagaa ccagttcagc      240

ctgaagctga gcagcgtgac cgctgccgac acagccgtgt actactgcgc caggtccgac      300

tacagcccct acgtgatgct cgcctggggc cagggaacac tggtgaccgt gagcagc         357


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucleotide sequence

<400>  14
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgcc agagcagcga ggacatctac agcggcctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacggc gccaacagcc tgcagagcgg cgtgcctagc      180

aggttcagcg gaagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcctgagga gccccttcac cttcggccag      300

ggcaccaagc tggagatcaa g                                                321


