                         SEQUENCE LISTING

<110>  WUXI BIOLOGICS (SHANGHAI) CO., LTD.
       WUXI BIOLOGICS IRELAND LIMITED
 
<120>  HUMANIZED ANTIBODIES AGAINST OX40, METHOD FOR PREPARING THE SAME, AND USE THEREOF

<130>  IEC196004PCT

<150>  PCT/CN2018/121267
<151>  2018-12-14

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 amino acid sequence

<400>  1

Gly Phe Asp Phe Asn Lys Tyr Trp Met Ser 
1               5                   10  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 amino acid sequence

<400>  2

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Val His 
1               5                   10                  15  


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 amino acid sequence

<400>  3

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 amino acid sequence

<400>  4

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 amino acid sequence

<400>  5

Tyr Asp Tyr Asp Trp Phe Ala Tyr 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 amino acid sequence

<400>  6

Gln Gln Ser Tyr Glu Asp Pro Arg Thr 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 amino acid sequence

<400>  7

Glu Ile Asn Pro Asp Ser Ser Thr Ile Gln Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 amino acid sequence

<400>  8

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region amino acid sequence

<400>  9

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn Lys Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Glu Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Asp Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region amino acid sequence

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
            100                 105                 110     


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region amino acid sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn Lys Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Asp Ser Ser Thr Ile Gln Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Glu Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Asp Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region amino acid sequence

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Val His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region amino acid sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn Lys Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Glu Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Asp Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable region nucleotide sequence

<400>  14
gaggtgaagc ttctcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtgcag cctcaggatt cgattttaat aaatattgga tgagttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attaatccag atagcagtac gataaactat      180

acgccatctc taaaggatga attcatcatc tccagagaca acgccaaaaa tacggtgtac      240

ctgcaaatga gaaaagtgag atctgaggac acagcccttt attactgtgc aacctatgat      300

tacgactggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  15
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable region nucleotide sequence

<400>  15
gacattgtac tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttgt tcactggtac      120

cagcagaaac caggacagtc acccaaactc ctcatctttc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagttatga ggatcctcgg      300

acgtttggtg gaggcaccaa gcttgaagtc aaa                                   333


<210>  16
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable region nucleotide sequence

<400>  16
gaggtgcagc tggtggagag cggcggagga ctggtgcagc ctggaggcag cctgagactg       60

agctgtgccg ccagcggctt cgacttcaac aagtactgga tgagctgggt gagacaggcc      120

cctggcaaag gactggagtg ggtggccgag atcaaccccg acagcagcac catccagtac      180

acccccagcc tgaaggacga gttcaccatc agcagggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgag agccgaagac accgccgtgt actactgcgc cacctacgac      300

tacgactggt tcgcctactg gggccaggga accctggtga ccgtgagcag c               351


<210>  17
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable region nucleotide sequence

<400>  17
gacatcgtgc tgacacagag ccctgccagc ctggctgtga gccctggaca gagggccacc       60

atcacctgca gggccagcga gagcgtggac agctacggca acagcttcgt gcactggtac      120

cagcagaagc ccggccagcc ccctaagctg ctgatcttca gagccagcaa cctggagagc      180

ggcgtgcctg ccagatttag cggcagcggc agcggcaccg atttcaccct gaccatcaac      240

cccgtggagg ccgacgacac cgccaactac tactgccagc agagctacga ggatcccagg      300

accttcggcc agggcaccaa gctggagatc aag                                   333


<210>  18
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable region nucleotide sequence

<400>  18
gaggtgcagc tggtggagag cggcggagga ctggtgcagc ctggaggcag cctgagactg       60

agctgtgccg ccagcggctt cgacttcaac aagtactgga tgagctgggt gagacaggcc      120

cctggcaaag gactggagtg ggtggccgag atcaaccccg acagcagcac catcaactac      180

gcccccagcc tgaaggacga gttcaccatc agcagggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgag agccgaagac accgccgtgt actactgcgc cacctacgac      300

tacgactggt tcgcctactg gggccaggga accctggtga ccgtgagcag c               351


