SEQUENCE LISTING

<110>   4D PHARMA RESEARCH LIMITED

<120>   COMPOSITIONS COMPRISING BACTERIAL STRAINS

<130>   P074407WO

<150>   EP18212006.3 
<151>   2018-12-12

<150>   GB1820745.6 
<151>   2018-12-19

<150>   GB1906732.1
<151>   2019-05-13
  
<150>   GB1914856.8
<151>   2019-10-14
 
<160>   7

<170>   SeqWin2010, version 1.0

<210>   1
<211>   1519
<212>   DNA
<213>   Megasphaera massiliensis gene for 16S ribosomal RNA, partial sequence, strain: NP3 - JX424772.1

<400>   1
agagtttgat cctggctcag gacgaacgct ggcggcgtgc ttaacacatg caagtcgaac  60
gagaagagat gagaagcttg cttcttatca attcgagtgg caaacgggtg agtaacgcgt  120
aagcaacctg cccttcagat ggggacaaca gctggaaacg gctgctaata ccgaatacgt  180
tctttccgcc gcatgacggg aagaagaaag ggaggccttc gggctttcgc tggaggaggg  240
gcttgcgtct gattagctag ttggaggggt aacggcccac caaggcgacg atcagtagcc  300
ggtctgagag gatgaacggc cacattggga ctgagacacg gcccagactc ctacgggagg  360
cagcagtggg gaatcttccg caatggacga aagtctgacg gagcaacgcc gcgtgaacga  420
tgacggcctt cgggttgtaa agttctgtta tatgggacga acagggcatc ggttaatacc  480
cggtgtcttt gacggtaccg taagagaaag ccacggctaa ctacgtgcca gcagccgcgg  540
taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggcgc gcaggcggca  600
tcgcaagtcg gtcttaaaag tgcggggctt aaccccgtga ggggaccgaa actgtgaagc  660
tcgagtgtcg gagaggaaag cggaattcct agtgtagcgg tgaaatgcgt agatattagg  720
aggaacacca gtggcgaaag cggctttctg gacgacaact gacgctgagg cgcgaaagcc  780
aggggagcaa acgggattag ataccccggt agtcctggcc gtaaacgatg gatactaggt  840
gtaggaggta tcgactcctt ctgtgccgga gttaacgcaa taagtatccc gcctggggag  900
tacggccgca aggctgaaac tcaaaggaat tgacgggggc ccgcacaagc ggtggagtat  960
gtggtttaat tcgacgcaac gcgaagaacc ttaccaagcc ttgacattga ttgctacgga  1020
aagagatttc cggttcttct tcggaagaca agaaaacagg tggtgcacgg ctgtcgtcag  1080
ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg caacccctat cttctgttgc  1140
cagcacctcg ggtggggact cagaagagac tgccgcagac aatgcggagg aaggcgggga  1200
tgacgtcaag tcatcatgcc ccttatggct tgggctacac acgtactaca atggctctta  1260
atagagggac gcgaaggagc gatccggagc aaaccccaaa aacagagtcc cagttcggat  1320
tgcaggctgc aactcgcctg catgaagcag gaatcgctag taatcgcagg tcagcatact  1380
gcggtgaata cgttcccggg ccttgtacac accgcccgtc acaccacgaa agtcattcac  1440
acccgaagcc ggtgaggcaa ccgcaaggaa ccagccgtcg aaggtggggg cgatgattgg  1500
ggtgaagtcg taacaaggt                                               1519

<210>   2
<211>   1398
<212>   DNA
<213>   consensus 16S rRNA sequence for Megasphaera massiliensis strain 42787

<400>   2
tgagaagctt gcttcttatc gattctagtg gcaaacgggt gagtaacgcg taagcaacct  60
gcccttcaga tggggacaac agctggaaac ggctgctaat accgaatacg ttctttccgc  120
cgcatgacgg gaagaagaaa gggaggcctt cgggctttcg ctggaggagg ggcttgcgtc  180
tgattagcta gttggagggg taacggccca ccaaggcgac gatcagtagc cggtctgaga  240
ggatgaacgg ccacattggg actgagacac ggcccagact cctacgggag gcagcagtgg  300
ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc cgcgtgaacg atgacggcct  360
tcgggttgta aagttctgtt atatgggacg aacaggacat cggttaatac ccggtgtctt  420
tgacggtacc gtaagagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta  480
ggtggcaagc gttgtccgga attattgggc gtaaagggcg cgcaggcggc atcgcaagtc  540
ggtcttaaaa gtgcggggct taaccccgtg aggggaccga aactgtgaag ctcgagtgtc  600
ggagaggaaa gcggaattcc tagtgtagcg gtgaaatgcg tagatattag gaggaacacc  660
agtggcgaaa gcggctttct ggacgacaac tgacgctgag gcgcgaaagc caggggagca  720
aacgggatta gataccccgg tagtcctggc cgtaaacgat ggatactagg tgtaggaggt  780
atcgactcct tctgtgccgg agttaacgca ataagtatcc cgcctgggga gtacggccgc  840
aaggctgaaa ctcaaaggaa ttgacggggg cccgcacaag cggtggagta tgtggtttaa  900
ttcgacgcaa cgcgaagaac cttaccaagc cttgacattg attgctacgg aaagagattt  960
ccggttcttc ttcggaagac aagaaaacag gtggtgcacg gctgtcgtca gctcgtgtcg  1020
tgagatgttg ggttaagtcc cgcaacgagc gcaaccccta tcttctgttg ccagcacctc  1080
gggtggggac tcagaagaga ctgccgcaga caatgcggag gaaggcgggg atgacgtcaa  1140
gtcatcatgc cccttatggc ttgggctaca cacgtactac aatggctctt aatagaggga  1200
agcgaaggag cgatccggag caaaccccaa aaacagagtc ccagttcgga ttgcaggctg  1260
caactcgcct gcatgaagca ggaatcgcta gtaatcgcag gtcagcatac tgcggtgaat  1320
acgttcccgg gccttgtaca caccgcccgt cacaccacga aagtcattca cacccgaagc  1380
cggtgaggca accgcaag                                                1398

<210>   3
<211>   1409
<212>   DNA
<213>   consensus 16S rRNA sequence for the Megasphaera strain deposited under accession number NCIMB 43385

<400>   3
ggctggttcc ttgcggttgc ctcaccggct tcgggtgtga atgactttcg tggtgtgacg  60
ggcggtgtgt acaaggcccg ggaacgtatt caccgcagta tgctgacctg cgattactag  120
cgattcctgc ttcatgcagg cgagttgcag cctgcaatcc gaactgggac tctgtttttg  180
gggtttgctc cggatcgctc cttcgcttcc ctctattaag agccattgta gtacgtgtgt  240
agcccaagcc ataaggggca tgatgacttg acgtcatccc cgccttcctc cgcattgtct  300
gcggcagtct cttctgagtc cccaccctta gtgctggcaa cagaagatag gggttgcgct  360
cgttgcggga cttaacccaa catctcacga cacgagctga cgacagccgt gcaccacctg  420
ttttcttgtc ttccgaagaa gaaccggaaa tctctttccg tagcaatcaa tgtcaaggct  480
tggtaaggtt cttcgcgttg cgtcgaatta aaccacatac tccaccgctt gtgcgggccc  540
ccgtcaattc ctttgagttt cagccttgcg gccgtactcc ccaggcggga tacttattgc  600
gttaactccg gcacagaagg agtcgatacc tcctacacct agtatccatc gtttacggcc  660
aggactaccg gggtatctaa tcccgtttgc tcccctggct ttcgcgcctc agcgtcagtt  720
gtcgtccaga aagccgcttt cgccactggt gttcctccta atatctacgc atttcaccgc  780
tacactagga attccgcttt cctctccgac actcgagctt cacagtttcg gtcccctcac  840
ggggttaagc cccgcacttt taagaccgac ttgcgatgcc gcctgcgcgc cctttacgcc  900
caataattcc ggacaacgct tgccacctac gtattaccgc ggctgctggc acgtagttag  960
ccgtggcttt ctcttacggt accgtcaggg ataacgggta ttgaccgcta tcctgttcgt  1020
cccatataac agaactttac aacccgaagg ccgtcatcgt tcacgcggcg ttgctccgtc  1080
agactttcgt ccattgcgga agattcccca ctgctgcctc ccgtaggagt ctgggccgtg  1140
tctcagtccc aatgtggccg ttcatcctct cagaccggct actgatcgtc gccttggtgg  1200
gccgttaccc ctccaactag ctaatcagac gcaagcccct cctccagcga aagcccgaag  1260
gcctcccttt cttcatcccg tcatgcggcg gaaagaacgt attcggtatt agcagccgtt  1320
tccagctgtt gtccccatct gaagggcagg ttgcttacgc gttactcacc cgtttgccac  1380
tcgaattgat aagaagcaag cttctcatc                                    1409

<210>   4
<211>   1415
<212>   DNA
<213>   consensus 16S rRNA sequence for the Megasphaera massilliensis strain deposited under accession number NCIMB 43388

<400>   4
ggctggttcc ttgcggttgc ctcaccggct tcgggtgtga atgactttcg tggtgtgacg  60
ggcggtgtgt acaaggcccg ggaacgtatt caccgcagta tgctgacctg cgattactag  120
cgattcctgc ttcatgcagg cgagttgcag cctgcaatcc gaactgggac tctgtttttg  180
gggtttgctc cggatcgctc cttcgcttcc ctctattaag agccattgta gtacgtgtgt  240
agcccaagcc ataaggggca tgatgacttg acgtcatccc cgccttcctc cgcattgtct  300
gcggcagtct cttctgagtc cccacccgag gtgctggcaa cagaagatag gggttgcgct  360
cgttgcggga cttaacccaa catctcacga cacgagctga cgacagccgt gcaccacctg  420
ttttcttgtc ttccgaagaa gaaccggaaa tctctttccg tagcaatcaa tgtcaaggct  480
tggtaaggtt cttcgcgttg cgtcgaatta aaccacatac tccaccgctt gtgcgggccc  540
ccgtcaattc ctttgagttt cagccttgcg gccgtactcc ccaggcggga tacttattgc  600
gttaactccg gcacagaagg agtcgatacc tcctacacct agtatccatc gtttacggcc  660
aggactaccg gggtatctaa tcccgtttgc tcccctggct ttcgcgcctc agcgtcagtt  720
gtcgtccaga aagccgcttt cgccactggt gttcctccta atatctacgc atttcaccgc  780
tacactagga attccgcttt cctctccgac actcgagctt cacagtttcg gtcccctcac  840
ggggttaagc cccgcacttt taagaccgac ttgcgatgcc gcctgcgcgc cctttacgcc  900
caataattcc ggacaacgct tgccacctac gtattaccgc ggctgctggc acgtagttag  960
ccgtggcttt ctcttacggt accgtcaaag acaccgggta ttaaccgatg tcctgttcgt  1020
cccatataac agaactttac aacccgaagg ccgtcatcgt tcacgcggcg ttgctccgtc  1080
agactttcgt ccattgcgga agattcccca ctgctgcctc ccgtaggagt ctgggccgtg  1140
tctcagtccc aatgtggccg ttcatcctct cagaccggct actgatcgtc gccttggtgg  1200
gccgttaccc ctccaactag ctaatcagac gcaagcccct cctccagcga aagcccgaag  1260
gcctcccttt cttcttcccg tcatgcggcg gaaagaacgt attcggtatt agcagccgtt  1320
tccagctgtt gtccccatct gaagggcagg ttgcttacgc gttactcacc cgtttgccac  1380
tagaatcgat aagaagcaag cttctcatgt cttct                             1415

<210>   5
<211>   1433
<212>   DNA
<213>   consensus 16S rRNA sequence for the Megasphaera massilliensis strain deposited under accession number NCIMB 43389

<400>   5
cgacggctgg ttccttgcgg ttgcctcacc ggcttcgggt gtgaatgact ttcgtggtgt  60
gacgggcggt gtgtacaagg cccgggaacg tattcaccgc agtatgctga cctgcgatta  120
ctagcgattc ctgcttcatg caggcgagtt gcagcctgca atccgaactg ggactctgtt  180
tttggggttt gctccggatc gctccttcgc ttccctctat taagagccat tgtagtacgt  240
gtgtagccca agccataagg ggcatgatga cttgacgtca tccccgcctt cctccgcatt  300
gtctgcggca gtctcttctg agtccccacc cgaggtgctg gcaacagaag ataggggttg  360
cgctcgttgc gggacttaac ccaacatctc acgacacgag ctgacgacag ccgtgcacca  420
cctgttttct tgtcttccga agaagaaccg gaaatctctt tccgtagcaa tcaatgtcaa  480
ggcttggtaa ggttcttcgc gttgcgtcga attaaaccac atactccacc gcttgtgcgg  540
gcccccgtca attcctttga gtttcagcct tgcggccgta ctccccaggc gggatactta  600
ttgcgttaac tccggcacag aaggagtcga tacctcctac acctagtatc catcgtttac  660
ggccaggact accggggtat ctaatcccgt ttgctcccct ggctttcgcg cctcagcgtc  720
agttgtcgtc cagaaagccg ctttcgccac tggtgttcct cctaatatct acgcatttca  780
ccgctacact aggaattccg ctttcctctc cgacactcga gcttcacagt ttcggtcccc  840
tcacggggtt aagccccgca cttttaagac cgacttgcga tgccgcctgc gcgcccttta  900
cgcccaataa ttccggacaa cgcttgccac ctacgtatta ccgcggctgc tggcacgtag  960
ttagccgtgg ctttctctta cggtaccgtc aaagacaccg ggtattaacc gatgccctgt  1020
tcgtcccata taacagaact ttacaacccg aaggccgtca tcgttcacgc ggcgttgctc  1080
cgtcagactt tcgtccattg cggaagattc cccactgctg cctcccgtag gagtctgggc  1140
cgtgtctcag tcccaatgtg gccgttcatc ctctcagacc ggctactgat cgtcgccttg  1200
gtgggccgtt acccctccaa ccagctaatc agacgcaagc ccctcctcca gcgaaagccc  1260
gaaggcctcc ctttcttctt cccgtcatgc ggcggaaaga acgtattcgg tattagcagc  1320
cgtttccagc tgttgtcccc atctgaaggg caggttgctt acgcgttact cacccgtttg  1380
ccactagaat cgataagaag caagcttctc atgtcttctc gttcgacttg cat         1433

<210>   6
<211>   1431
<212>   DNA
<213>   consensus 16S rRNA sequence for the Megasphaera strain deposited under accession number NCIMB 43386

<400>   6
cgacggctgg ttccttgcgg ttgcctcacc ggcttcgggt gtgaatgact ttcgtggtgt  60
gacgggcggt gtgtacaagg cccgggaacg tattcaccgc agtatgctga cctgcgatta  120
ctagcgattc ctgcttcatg caggcgagtt gcagcctgca atccgaactg ggactctgtt  180
tttggggttt gctccggatc gctccttcgc ttccctctat taagagccat tgtagtacgt  240
gtgtagccca agccataagg ggcatgatga cttgacgtca tccccgcctt cctccgcatt  300
gtctgcggca gtctcttctg agtccccacc cttagtgctg gcaacagaag ataggggttg  360
cgctcgttgc gggacttaac ccaacatctc acgacacgag ctgacgacag ccgtgcacca  420
cctgttttct tgtcttccga agaagaaccg gaaatctctt tccgtagcaa tcaatgtcaa  480
ggcttggtaa ggttcttcgc gttgcgtcga attaaaccac atactccacc gcttgtgcgg  540
gcccccgtca attcctttga gtttcagcct tgcggccgta ctccccaggc gggatactta  600
ttgcgttaac tccggcacag aaggagtcga tacctcctac acctagtatc catcgtttac  660
ggccaggact accggggtat ctaatcccgt ttgctcccct ggctttcgcg cctcagcgtc  720
agttgtcgtc cagaaagccg ctttcgccac tggtgttcct cctaatatct acgcatttca  780
ccgctacact aggaattccg ctttcctctc cgacactcga gcttcacagt ttcggtcccc  840
tcacggggtt aagccccgca cttttaagac cgacttgcga tgccgcctgc gcgcccttta  900
cgcccaataa ttccggacaa cgcttgccac ctacgtatta ccgcggctgc tggcacgtag  960
ttagccgtgg ctttctctta cggtaccgtc agggataacg ggtattgacc gctatcctgt  1020
tcgtcccata taacagaact ttacaacccg aaggccgtca tcgttcacgc ggcgttgctc  1080
cgtcagactt tcgtccattg cggaagattc cccactgctg cctcccgtag gagtctgggc  1140
cgtgtctcag tcccaatgtg gccgttcatc ctctcagacc ggctactgat cgtcgccttg  1200
gtgggccgtt acccctccaa ctagctaatc agacgcaagc ccctcctcca gcgaaagccc  1260
gaaggcctcc ctttcttcat cccgtcatgc ggcggaaaga acgtattcgg tattagcagc  1320
cgtttccagc tgttgtcccc atctgaaggg caggttgctt acgcgttact cacccgtttg  1380
ccactcgaat tgataagaag caagcttctc atctcttctc gttcgactgc a           1431

<210>   7
<211>   1434
<212>   DNA
<213>   consensus 16S rRNA sequence for the Megasphaera strain deposited under accession number NCIMB 43387

<400>   7
tcgaacggct ggttccttgc ggttgcctca ccggcttcgg gtgtgaatga ctttcgtggt  60
gtgacgggcg gtgtgtacaa ggcccgggaa cgtattcacc gcagtatgct gacctgcgat  120
tactagcgat tcctgcttca tgcaggcgag ttgcagcctg caatccgaac tgggactctg  180
tttttggggt ttgctccgga tcgctccttc gcttccctct attaagagcc attgtagtac  240
gtgtgtagcc caagccataa ggggcatgat gacttgacgt catccccgcc ttcctccgca  300
ttgtctgcgg cagtctcttc tgagtcccca cccttagtgc tggcaacaga agataggggt  360
tgcgctcgtt gcgggactta acccaacatc tcacgacacg agctgacgac agccgtgcac  420
cacctgtttt cttgtcttcc gaagaagaac cggaaatctc tttccgtagc aatcaatgtc  480
aaggcttggt aaggttcttc gcgttgcgtc gaattaaacc acatactcca ccgcttgtgc  540
gggcccccgt caattccttt gagtttcagc cttgcggccg tactccccag gcgggatact  600
tattgcgtta actccggcac agaaggagtc gatacctcct acacctagta tccatcgttt  660
acggccagga ctaccggggt atctaatccc gtttgctccc ctggctttcg cgcctcagcg  720
tcagttgtcg tccagaaagc cgctttcgcc actggtgttc ctcctaatat ctacgcattt  780
caccgctaca ctaggaattc cgctttcctc tccgacactc gagcttcaca gtttcggtcc  840
cctcacgggg ttaagccccg cacttttaag accgacttgc gatgccgcct gcgcgccctt  900
tacgcccaat aattccggac aacgcttgcc acctacgtat taccgcggct gctggcacgt  960
agttagccgt ggctttctct tacggtaccg tcagggataa cgggtattga ccgctatcct  1020
gttcgtccca tataacagaa ctttacaacc cgaaggccgt catcgttcac gcggcgttgc  1080
tccgtcagac tttcgtccat tgcggaagat tccccactgc tgcctcccgt aggagtctgg  1140
gccgtgtctc agtcccaatg tggccgttca tcctctcaga ccggctactg atcgtcgcct  1200
tggtgggccg ttacccctcc aactagctaa tcagacgcaa gcccctcctc cagcgaaagc  1260
ccgaaggcct ccctttcttc atcccgtcat gcggcggaaa gaacgtattc ggtattagca  1320
gccgtttcca gctgttgtcc ccatctgaag ggcaggttgc ttacgcgtta ctcacccgtt  1380
tgccactcga attgataaga agcaagcttc tcatctcttc tcgttcgact tgca        1434

