                         SEQUENCE LISTING

<110>  BicycleTx Limited
 
<120>  BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP

<130>  BIC-C-P2491PCT

<150>  GB1820286.1
<151>  2018-12-13

<150>  GB1906534.1
<151>  2019-05-09

<160>  144   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Cys Glu Glu Ser Phe Tyr Pro Glu Cys Asp His Cys 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Cys Pro Asp Leu Cys Leu Asp Leu Phe Pro Asn Cys 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Cys Pro Glu Leu Cys Val Asp Leu Tyr Pro His Cys 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Cys His Pro Glu Trp Val Ser Cys Glu Phe His Cys 
1               5                   10          


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Cys Ser His Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Cys Phe Asp Glu Cys Gln Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Cys Leu Asp Glu Cys Lys Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Cys Arg Glu Glu Cys Met Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Cys Glu Thr Glu Cys Ala Leu Leu Phe Pro Arg Ser Cys 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Cys Ala Asp Glu Cys Arg Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Cys Asp Val Glu Cys Arg Leu Leu Phe Pro Arg Ser Cys 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Cys Ile Asp Glu Cys Arg Leu Leu Phe Pro Arg Ser Cys 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Cys Val Arg Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<400>  14

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Cys Val Arg Glu Cys Ala Leu Leu Phe Pro Arg Thr Cys 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  16

Cys Val Arg Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  17

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<400>  18

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Ala Thr Cys 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  19

Cys Val Ala Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Cys Val Thr Glu Cys Gln Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Cys Arg His Glu Cys Glu Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Cys Gln Arg Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Cys Val Arg Glu Cys Thr Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Cys Thr Ile Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Cys Ala Arg Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Cys Ile Asn Glu Cys Arg Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Cys Tyr Thr Glu Cys Ser Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Cys His Glu Glu Cys Arg Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Cys Leu Glu Glu Cys Lys Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Cys Ile Asp Glu Cys Ala Leu Leu Phe Pro Arg Thr Cys 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Cys Tyr Glu Glu Cys Arg Leu Leu Phe Pro Arg Thr Cys 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Cys Val Arg Glu Cys Arg Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Cys His Ile Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Cys Lys Arg Glu Cys Met Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Cys Tyr Arg Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Cys Leu Thr Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Cys Glu Val Glu Cys Arg Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Cys Glu Ala Glu Cys Arg Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Cys Val Gln Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Cys Ile Arg Glu Cys Ser Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Cys Val Thr Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Cys Val Ala Glu Cys Lys Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Cys Val Gly Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Cys Val Val Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Cys Val Phe Glu Cys Ala Leu Leu Phe Pro Lys Thr Cys 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  46

Cys Ala Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  47

Cys Val Xaa Glu Cys Ala Leu Leu Phe Ala Xaa Thr Cys 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  48

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Ala Cys 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa represents 1Nal

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  49

Cys Val Xaa Glu Cys Ala Leu Leu Xaa Pro Xaa Thr Cys 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa represents Cha

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  50

Cys Val Xaa Glu Cys Ala Leu Leu Xaa Pro Xaa Thr Cys 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents Pip

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  51

Cys Val Xaa Glu Cys Ala Leu Leu Phe Xaa Xaa Thr Cys 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  52

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Ser Cys 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa represents HSer

<400>  53

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Xaa Cys 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents HyP

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  54

Cys Val Xaa Glu Cys Ala Leu Leu Phe Xaa Xaa Thr Cys 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa represents Aib

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  55

Cys Val Xaa Glu Cys Xaa Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  56

Cys Val Xaa Glu Cys Ala Leu Xaa Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents tBuAla

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  57

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents Nle

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  58

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents Aad2

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  59

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  60

Cys Pro Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  61
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa represents 4FlPhe

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  61

Cys Val Xaa Glu Cys Ala Leu Leu Xaa Pro Xaa Thr Cys 
1               5                   10              


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents tBuGly

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  62

Cys Val Xaa Glu Cys Ala Leu Xaa Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents Cha

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  63

Cys Val Xaa Glu Cys Ala Leu Xaa Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa represents 2Nal

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  64

Cys Val Xaa Glu Cys Ala Leu Leu Xaa Pro Xaa Thr Cys 
1               5                   10              


<210>  65
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa represents HyV

<400>  65

Cys Val Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Xaa Cys 
1               5                   10              


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa represents tBuGly

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  66

Cys Xaa Xaa Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  67

Cys Val Glu Glu Cys Ala Leu Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents Cpa

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  68

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents Cba

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  69

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents C5A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  70

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents Cha

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  71

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents tBuGly

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  72

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  73
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents cis-HyP

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  73

Cys Val Xaa Glu Cys Ala Leu Leu Phe Xaa Xaa Thr Cys 
1               5                   10              


<210>  74
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents Cpa

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  74

Cys Val Xaa Glu Cys Ala Leu Xaa Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents C5A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  75

Cys Val Xaa Glu Cys Ala Leu Xaa Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents tBuAla

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents HyP

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  76

Cys Val Xaa Glu Cys Ala Xaa Leu Phe Xaa Xaa Thr Cys 
1               5                   10              


<210>  77
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents tBuAla

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents tBuGly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents HyP

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  77

Cys Val Xaa Glu Cys Ala Xaa Xaa Phe Xaa Xaa Thr Cys 
1               5                   10              


<210>  78
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa represents tBuGly

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents HArg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents tBuAla

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents HArg

<400>  78

Cys Xaa Xaa Glu Cys Ala Xaa Leu Phe Pro Xaa Thr Cys 
1               5                   10              


<210>  79
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79

Cys Ser Ser Trp Asp Lys Leu Met Cys His Pro Tyr Cys 
1               5                   10              


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Cys Pro Glu Glu Cys Phe Tyr Leu Pro Pro His Pro Met Ser Cys 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81

Cys Pro Gln Glu Cys Phe Tyr Leu Pro Gly His Ser Leu Tyr Cys 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His Pro Leu Ala Cys 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83

Cys Pro Gly Glu Cys Phe Tyr Pro Thr Asn His Pro Leu Tyr Cys 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84

Cys Pro Gln Glu Cys Phe Tyr Pro Ile Gly His Pro Leu Ala Cys 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85

Cys Pro Glu Glu Cys Phe Tyr Pro Pro Gly His Lys Leu His Cys 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  86

Cys Pro Gln Glu Cys Phe Tyr Pro Pro Gly His Arg Leu Arg Cys 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87

Cys Pro Gln Glu Cys Phe Tyr Pro Pro Gly His Pro Tyr His Cys 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88

Cys Pro Gln Glu Cys Phe Tyr Pro Ser Thr His Pro Leu Tyr Cys 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89

Cys Pro Gly Glu Cys Phe Tyr Pro Ser Asn His Arg Leu Tyr Cys 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  90

Cys Pro Asp Glu Cys Phe Tyr Pro Pro Glu His Pro Leu Ala Cys 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  91

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His His Leu Ser Cys 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His His Leu Gly Cys 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93

Cys Pro Glu Glu Cys Phe Tyr Pro Pro Asn His Pro Leu Tyr Cys 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Asp His Pro Leu Tyr Cys 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His Pro Leu Tyr Cys 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Asn His Pro Phe Tyr Cys 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Asn His Pro Leu Tyr Cys 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98

Cys Pro Glu Glu Cys Phe Tyr Pro Pro Gly His Pro Leu Ala Cys 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99

Cys Trp Met Glu Cys Phe Tyr Pro Pro Gly His Pro Leu Ala Cys 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100

Cys Phe Glu Glu Cys Phe Tyr Pro Pro Gly His Pro Leu Ala Cys 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His Pro Leu Arg Cys 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His Pro Arg Glu Cys 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His Arg Phe His Cys 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104

Cys Pro Gly Glu Cys Phe Tyr Pro Pro Gly His Arg Leu Tyr Cys 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105

Cys Glu Glu Glu Phe Tyr Pro Cys Gly His Pro Leu Tyr Val Cys 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106

Cys Glu Glu Gln Phe Tyr Pro Cys Thr His Ala Leu Tyr Thr Cys 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107

Cys Val Glu Glu Phe Tyr Pro Cys Asp His Pro Leu Tyr Ser Cys 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108

Cys Glu Glu Glu Phe Tyr Pro Cys Gly His Pro Met His Pro Cys 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  109

Cys Asp Glu Gln Phe Tyr Pro Cys His His Arg Leu Tyr Ser Cys 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  110

Cys Glu Glu Glu Phe Tyr Pro Cys Gly His Pro Phe His Pro Cys 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  111

Cys Leu Glu Gln Phe Tyr Pro Cys Glu His Pro Leu Phe Ser Cys 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  112

Cys Val Glu Gln Phe Tyr Pro Cys Gly His Arg His Tyr Ile Cys 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  113

Cys Glu Glu Gln Phe Tyr Pro Cys Ser His Pro Leu Tyr Thr Cys 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  114

Cys Glu Glu Gln Phe Tyr Pro Cys Asn His Pro Leu Asn Val Cys 
1               5                   10                  15  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  115

Cys Glu Glu Glu Phe Tyr Pro Cys Ser His Pro Leu Asn Pro Cys 
1               5                   10                  15  


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  116

Cys Glu Glu Gln Phe Tyr Pro Cys Gly His Lys Leu Ser Pro Cys 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  117

Cys Pro Glu Gln Phe Tyr Pro Cys Asp His Arg Leu Tyr Ile Cys 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  118

Cys Gln Glu Gln Phe Tyr Pro Cys Asn His Pro Leu Ser Pro Cys 
1               5                   10                  15  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  119

Cys Asp Glu Gln Phe Tyr Pro Cys Asn His Arg Leu Asn Thr Cys 
1               5                   10                  15  


<210>  120
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  120

Cys Glu Glu Ala Phe Tyr Pro Cys His His Pro Leu Tyr Arg Cys 
1               5                   10                  15  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  121

Cys Asp Glu Asp Phe Tyr Pro Cys Gly His Tyr Leu Asn Gln Cys 
1               5                   10                  15  


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  122

Cys Glu Glu Gln Phe Tyr Pro Cys Thr His Pro Leu Tyr Val Cys 
1               5                   10                  15  


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  123

Cys Pro Glu Gln Phe Tyr Pro Cys Thr His Arg Leu Tyr Gln Cys 
1               5                   10                  15  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  124

Cys Glu Glu Gln Phe Tyr Pro Cys Ser His Pro Leu Tyr Arg Cys 
1               5                   10                  15  


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  125

Cys Ala Glu Gln Phe Tyr Pro Cys Asp His Pro Leu Tyr Arg Cys 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  126

Cys Ala Glu Glu Phe Tyr Pro Cys Asp His Pro Leu Tyr Arg Cys 
1               5                   10                  15  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  127

Cys Glu Glu Ala Phe Tyr Pro Cys Asn His Pro Leu Tyr Thr Cys 
1               5                   10                  15  


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  128

Cys Ala Glu Ala Phe Tyr Pro Cys Asp His Pro Leu Tyr Val Cys 
1               5                   10                  15  


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  129

Cys Glu Glu Ala Phe Tyr Pro Cys Ser His Pro Leu Phe Ile Cys 
1               5                   10                  15  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  130

Cys Glu Glu Ala Phe Tyr Pro Cys Ser His Pro Leu His Pro Cys 
1               5                   10                  15  


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  131

Cys Glu Glu Ala Phe Tyr Pro Cys Ser His Pro Leu Phe Val Cys 
1               5                   10                  15  


<210>  132
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  132

Cys Glu Glu Gln Phe Tyr Pro Cys Ser His Pro Leu Tyr Ser Cys 
1               5                   10                  15  


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  133

Cys Glu Glu Ala Phe Tyr Pro Cys Glu His Pro Leu Tyr Met Cys 
1               5                   10                  15  


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  134

Cys Glu Glu Gln Phe Tyr Pro Cys Asn His Pro Leu Tyr Met Cys 
1               5                   10                  15  


<210>  135
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  135

Cys Leu Glu Gln Phe Tyr Pro Cys Gly Asp Pro Arg Leu Cys 
1               5                   10                  


<210>  136
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  136

Cys Glu Glu Gln Phe Tyr Pro Cys Gly His His Leu Leu Cys 
1               5                   10                  


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  137

Cys Leu Glu Pro Asp Glu Cys Phe Tyr Pro Met Glu Cys 
1               5                   10              


<210>  138
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  138

Cys Lys Glu Pro Gln Glu Cys Phe Tyr Pro Leu Lys Cys 
1               5                   10              


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  139

Cys Asp Ser Pro Glu Glu Cys Phe Tyr Pro Leu Glu Cys 
1               5                   10              


<210>  140
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  140

Ala Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys Ala 
1               5                   10                  15      


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  141

Ala Cys Met Asn Gln Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys Ala 
1               5                   10                  15      


<210>  142
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  142

Ala Cys Tyr Asn Glu Phe Ala Cys Glu Asp Phe Tyr Asp Ile Cys Ala 
1               5                   10                  15      


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  143

Ala Cys Pro Tyr Ser Trp Glu Thr Cys Leu Phe Gly Asp Tyr Arg Cys 
1               5                   10                  15      


Ala 
    


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  144

Ala Cys Pro Tyr Asp Trp Ala Thr Cys Leu Phe Gly Asp Tyr Arg Cys 
1               5                   10                  15      


Ala 
    


