                         SEQUENCE LISTING

<110>  AMGEN INC.
 
<120>  CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF

<130>  A-2327-WO-PCT

<150>  62/777,677
<151>  2018-12-10

<160>  127   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
cggccaaugu ccaccagcuu u                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
cggccaaugu ccaccagcuu u                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
gguccagccu gaacuucuuu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
gguccagccu gaacuucuuu u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
gcuucaugcc cuucuacagu u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
gcuucaugcc cuucuacagu u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gcggcuuccu gggcuucuau u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
gcggcuuccu gggcuucuau u                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gugacaacgu acccuucauu u                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
gugacaacgu acccuucauu u                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gguauguucc ugcuucaugu u                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
gguauguucc ugcuucaugu u                                                 21


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
guauguuccu gcuucaugcu u                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
guauguuccu gcuucaugcu u                                                 21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
uguuccugcu ucaugcccuu u                                                 21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
uguuccugcu ucaugcccuu u                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
guuccugcuu caugcccuuu u                                                 21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
guuccugcuu caugcccuuu u                                                 21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
ccugcuucau gcccuucuau u                                                 21


<210>  20
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
ccugcuucau gcccuucuau u                                                 21


<210>  21
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
cuucaugccc uucuacaguu u                                                 21


<210>  22
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
cuucaugccc uucuacaguu u                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
uucaugcccu ucuacagugu u                                                 21


<210>  24
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
uucaugcccu ucuacagugu u                                                 21


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
augcccuucu acaguggccu u                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
augcccuucu acaguggccu u                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gcuucaugcc cuucuacauu u                                                 21


<210>  28
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
gcuucaugcc cuucuacauu u                                                 21


<210>  29
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
cugcuucaug cccuucuaca                                                   20


<210>  30
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
cugcuucaug cccuucuaca u                                                 21


<210>  31
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
cugcuucaug ccuuucuaca                                                   20


<210>  32
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
cugcuucaug ccuuucuaca                                                   20


<210>  33
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
ugcuucaugc cuuucuacag                                                   20


<210>  34
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
ugcuucaugc cuuucuacag                                                   20


<210>  35
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
cugcuucaug ccuuucuaca                                                   20


<210>  36
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
cugcuucaug ccuuucuaca u                                                 21


<210>  37
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
cugcuucaug ccuuucuaca u                                                 21


<210>  38
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
cugcuucaug ccuuucuaca                                                   20


<210>  39
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
ugcuucaugc cuuucuacag                                                   20


<210>  40
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
agcuggugga cauuggccgu u                                                 21


<210>  41
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
agcuggugga cauuggccgu u                                                 21


<210>  42
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
aagaaguuca ggcuggaccu u                                                 21


<210>  43
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
aagaaguuca ggcuggaccu u                                                 21


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
cuguagaagg gcaugaagcu u                                                 21


<210>  45
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
cuguagaagg gcaugaagcu u                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
uagaagccca ggaagccgcu u                                                 21


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
uagaagccca ggaagccgcu u                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
augaagggua cguugucacu u                                                 21


<210>  49
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
augaagggua cguugucacu u                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
caugaagcag gaacauaccu u                                                 21


<210>  51
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
caugaagcag gaacauaccu u                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
gcaugaagca ggaacauacu u                                                 21


<210>  53
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
gcaugaagca ggaacauacu u                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
agggcaugaa gcaggaacau u                                                 21


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
agggcaugaa gcaggaacau u                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
aagggcauga agcaggaacu u                                                 21


<210>  57
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
aagggcauga agcaggaacu u                                                 21


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
uagaagggca ugaagcaggu u                                                 21


<210>  59
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
uagaagggca ugaagcaggu u                                                 21


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
acuguagaag ggcaugaagu u                                                 21


<210>  61
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
acuguagaag ggcaugaagu u                                                 21


<210>  62
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
cacuguagaa gggcaugaau u                                                 21


<210>  63
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
cacuguagaa gggcaugaau u                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
ggccacugua gaagggcauu u                                                 21


<210>  65
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
ggccacugua gaagggcauu u                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
ggccacugua gaagggcauu u                                                 21


<210>  67
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
auguagaagg gcaugaagca guu                                               23


<210>  68
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
auguagaaag gcaugaagca guu                                               23


<210>  69
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
auguagaaag gcaugaagca guu                                               23


<210>  70
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
auguagaaag gcaugaagca guu                                               23


<210>  71
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
auguagaaag gcaugaagca guu                                               23


<210>  72
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
acuguagaaa ggcaugaagc auu                                               23


<210>  73
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
ucuguagaaa ggcaugaagc auu                                               23


<210>  74
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
auguagaaag gcaugaagca guu                                               23


<210>  75
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  75
auguagaaag gcaugaagca guu                                               23


<210>  76
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  76
auguagaaag gcaugaagca guu                                               23


<210>  77
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
auguagaaag gcaugaagca guu                                               23


<210>  78
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
auguagaaag gcaugaagca guu                                               23


<210>  79
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
auguagaaag gcaugaagca guu                                               23


<210>  80
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  80
auguagaaag gcaugaagca guu                                               23


<210>  81
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  81
gugggaagaa agaugaaguu u                                                 21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  82
gugggaagaa agaugaaguu u                                                 21


<210>  83
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  83
acuucaucuu ucuucccacu u                                                 21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  84
acuucaucuu ucuucccacu u                                                 21


<210>  85
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  85
gccccuuauu guuauacgau u                                                 21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  86
gccccuuauu guuauacgau u                                                 21


<210>  87
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  87
acacaaugcu cagacgcagu u                                                 21


<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
ugacacaaug cucagacgca g                                                 21


<210>  89
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  89
ugacacaaug cucagacgca                                                   20


<210>  90
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  90
acacaaugcu cagacgcaau                                                   20


<210>  91
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  91
acacaaugcu cagacgca                                                     18


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  92
ccuagaggcu ccuucugaau u                                                 21


<210>  93
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  93
agccuagagg cuccuucuga a                                                 21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  94
uucgcccuug guguuacacc a                                                 21


<210>  95
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  95
cgcccuuggu guuacaccau u                                                 21


<210>  96
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  96
cgcccuuggu guuacacca                                                    19


<210>  97
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  97
cagaaucaag uguccuugca                                                   20


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  98
gaaucaagug uccuugcaau u                                                 21


<210>  99
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  99
cagaaucaag uguccuugca                                                   20


<210>  100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  100
aaucaagugu ccuugcaauu                                                   20


<210>  101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  101
agaaucaagu guccuugcaa                                                   20


<210>  102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  102
agucuugguc cucuaugaca                                                   20


<210>  103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  103
agucuugguc cucuaugaca                                                   20


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  104
uucugaagaa gcaccaacuu u                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  105
uucugaagaa gcaccaacuu u                                                 21


<210>  106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  106
ccuucugaag aagcaccaac                                                   20


<210>  107
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  107
ucguauaaca auaaggggcu u                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  108
ucguauaaca auaaggggcu u                                                 21


<210>  109
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  109
cugcgucuga gcauuguguu u                                                 21


<210>  110
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  110
cugcgucuga gcauuguguc auu                                               23


<210>  111
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  111
uugcgucuga gcauuguguc auu                                               23


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  112
uugcgucuga gcauuguguu u                                                 21


<210>  113
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  113
uucagaagga gccucuaggu u                                                 21


<210>  114
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  114
uucagaagga gccucuaggc uuu                                               23


<210>  115
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  115
ugguguaaca ccaagggcga auu                                               23


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  116
ugguguaaca ccaagggcgu u                                                 21


<210>  117
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  117
ugguguaaca ccaagggcgu u                                                 21


<210>  118
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  118
uugcaaggac acuugauucu guu                                               23


<210>  119
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  119
uugcaaggac acuugauucu u                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  120
uugcaaggac acuugauucu g                                                 21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  121
auugcaagga cacuugauuu u                                                 21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  122
auugcaagga cacuugauuc u                                                 21


<210>  123
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  123
augucauaga ggaccaagac uuu                                               23


<210>  124
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  124
augucauaga ggaccaagac uuu                                               23


<210>  125
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  125
augucauaga ggaccaagac uuu                                               23


<210>  126
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  126
aguuggugcu ucuucagaau u                                                 21


<210>  127
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  127
aguuggugcu ucuucagaag guu                                               23


