                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Engineered polypeptides that exhibit increased catalytic 
       efficiency for unnatural cofactors and uses thereof

<130>  00058-037W01

<140>  Not Yet Assigned
<141>  2019-12-10

<150>  US 62/777,725
<151>  2018-12-10

<150>  US 62/852,936
<151>  2019-05-24

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  261
<212>  PRT
<213>  Bacillus subtilis

<400>  1

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  2
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I195R mutant GDH coding sequence

<400>  2

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Arg Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  3
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A93K mutant GDH coding sequence

<400>  3

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Lys Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  4
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y39Q mutant GDH coding sequence

<400>  4

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Gln Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  5
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S17E mutant GDH coding sequence

<400>  5

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Glu Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  6
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I195R A93K Y39Q mutant GDH coding sequence

<400>  6

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Gln Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Lys Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Arg Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  7
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I195R A93K Y39Q S17E mutant GDH coding sequence

<400>  7

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Glu Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Gln Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Lys Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Arg Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  8
<211>  165
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Thr Asp Ser Glu Leu Met Gln Leu Ser Glu Gln Val Gly Gln Ala 
1               5                   10                  15      


Leu Lys Ala Arg Gly Ala Thr Val Thr Thr Ala Glu Ser Cys Thr Gly 
            20                  25                  30          


Gly Trp Val Ala Lys Val Ile Thr Asp Ile Ala Gly Ser Ser Ala Trp 
        35                  40                  45              


Phe Glu Arg Gly Phe Val Thr Tyr Ser Asn Glu Ala Lys Ala Gln Met 
    50                  55                  60                  


Ile Gly Val Arg Glu Glu Thr Leu Ala Gln His Gly Ala Val Ser Glu 
65                  70                  75                  80  


Pro Val Val Val Glu Met Ala Ile Gly Ala Leu Lys Ala Ala Arg Ala 
                85                  90                  95      


Asp Tyr Ala Val Ser Ile Ser Gly Ile Ala Gly Pro Asp Gly Gly Ser 
            100                 105                 110         


Glu Glu Lys Pro Val Gly Thr Val Trp Phe Ala Phe Ala Thr Ala Arg 
        115                 120                 125             


Gly Glu Gly Ile Thr Arg Arg Glu Cys Phe Ser Gly Asp Arg Asp Ala 
    130                 135                 140                 


Val Arg Arg Gln Ala Thr Ala Tyr Ala Leu Gln Thr Leu Trp Gln Gln 
145                 150                 155                 160 


Phe Leu Gln Asn Thr 
                165 


<210>  9
<211>  410
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ser Ser Phe Asp Tyr Leu Lys Thr Ala Ile Lys Gln Gln Gly Cys 
1               5                   10                  15      


Thr Leu Gln Gln Val Ala Asp Ala Ser Gly Met Thr Lys Gly Tyr Leu 
            20                  25                  30          


Ser Gln Leu Leu Asn Ala Lys Ile Lys Ser Pro Ser Ala Gln Lys Leu 
        35                  40                  45              


Glu Ala Leu His Arg Phe Leu Gly Leu Glu Phe Pro Arg Gln Lys Lys 
    50                  55                  60                  


Thr Ile Gly Val Val Phe Gly Lys Phe Tyr Pro Leu His Thr Gly His 
65                  70                  75                  80  


Ile Tyr Leu Ile Gln Arg Ala Cys Ser Gln Val Asp Glu Leu His Ile 
                85                  90                  95      


Ile Met Gly Phe Asp Asp Thr Arg Asp Arg Ala Leu Phe Glu Asp Ser 
            100                 105                 110         


Ala Met Ser Gln Gln Pro Thr Val Pro Asp Arg Leu Arg Trp Leu Leu 
        115                 120                 125             


Gln Thr Phe Lys Tyr Gln Lys Asn Ile Arg Ile His Ala Phe Asn Glu 
    130                 135                 140                 


Glu Gly Met Glu Pro Tyr Pro His Gly Trp Asp Val Trp Ser Asn Gly 
145                 150                 155                 160 


Ile Lys Lys Phe Met Ala Glu Lys Gly Ile Gln Pro Asp Leu Ile Tyr 
                165                 170                 175     


Thr Ser Glu Glu Ala Asp Ala Pro Gln Tyr Met Glu His Leu Gly Ile 
            180                 185                 190         


Glu Thr Val Leu Val Asp Pro Lys Arg Thr Phe Met Ser Ile Ser Gly 
        195                 200                 205             


Ala Gln Ile Arg Glu Asn Pro Phe Arg Tyr Trp Glu Tyr Ile Pro Thr 
    210                 215                 220                 


Glu Val Lys Pro Phe Phe Val Arg Thr Val Ala Ile Leu Gly Gly Glu 
225                 230                 235                 240 


Ser Ser Gly Lys Ser Thr Leu Val Asn Lys Leu Ala Asn Ile Phe Asn 
                245                 250                 255     


Thr Thr Ser Ala Trp Glu Tyr Gly Arg Asp Tyr Val Phe Ser His Leu 
            260                 265                 270         


Gly Gly Asp Glu Ile Ala Leu Gln Tyr Ser Asp Tyr Asp Lys Ile Ala 
        275                 280                 285             


Leu Gly His Ala Gln Tyr Ile Asp Phe Ala Val Lys Tyr Ala Asn Lys 
    290                 295                 300                 


Val Ala Phe Ile Asp Thr Asp Phe Val Thr Thr Gln Ala Phe Cys Lys 
305                 310                 315                 320 


Lys Tyr Glu Gly Arg Glu His Pro Phe Val Gln Ala Leu Ile Asp Glu 
                325                 330                 335     


Tyr Arg Phe Asp Leu Val Ile Leu Leu Glu Asn Asn Thr Pro Trp Val 
            340                 345                 350         


Ala Asp Gly Leu Arg Ser Leu Gly Ser Ser Val Asp Arg Lys Glu Phe 
        355                 360                 365             


Gln Asn Leu Leu Val Glu Met Leu Glu Glu Asn Asn Ile Glu Phe Val 
    370                 375                 380                 


Arg Val Glu Glu Glu Asp Tyr Asp Ser Arg Phe Leu Arg Cys Val Glu 
385                 390                 395                 400 


Leu Val Arg Glu Met Met Gly Glu Gln Arg 
                405                 410 


<210>  10
<211>  549
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Lys Asn Ile Asn Pro Thr Gln Thr Ala Ala Trp Gln Ala Leu Gln 
1               5                   10                  15      


Lys His Phe Asp Glu Met Lys Asp Val Thr Ile Ala Asp Leu Phe Ala 
            20                  25                  30          


Lys Asp Gly Asp Arg Phe Ser Lys Phe Ser Ala Thr Phe Asp Asp Gln 
        35                  40                  45              


Met Leu Val Asp Tyr Ser Lys Asn Arg Ile Thr Glu Glu Thr Leu Ala 
    50                  55                  60                  


Lys Leu Gln Asp Leu Ala Lys Glu Cys Asp Leu Ala Gly Ala Ile Lys 
65                  70                  75                  80  


Ser Met Phe Ser Gly Glu Lys Ile Asn Arg Thr Glu Asn Arg Ala Val 
                85                  90                  95      


Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu Val Asp 
            100                 105                 110         


Gly Lys Asp Val Met Pro Glu Val Asn Ala Val Leu Glu Lys Met Lys 
        115                 120                 125             


Thr Phe Ser Glu Ala Ile Ile Ser Gly Glu Trp Lys Gly Tyr Thr Gly 
    130                 135                 140                 


Lys Ala Ile Thr Asp Val Val Asn Ile Gly Ile Gly Gly Ser Asp Leu 
145                 150                 155                 160 


Gly Pro Tyr Met Val Thr Glu Ala Leu Arg Pro Tyr Lys Asn His Leu 
                165                 170                 175     


Asn Met His Phe Val Ser Asn Val Asp Gly Thr His Ile Ala Glu Val 
            180                 185                 190         


Leu Lys Lys Val Asn Pro Glu Thr Thr Leu Phe Leu Val Ala Ser Lys 
        195                 200                 205             


Thr Phe Thr Thr Gln Glu Thr Met Thr Asn Ala His Ser Ala Arg Asp 
    210                 215                 220                 


Trp Phe Leu Lys Ala Ala Gly Asp Glu Lys His Val Ala Lys His Phe 
225                 230                 235                 240 


Ala Ala Leu Ser Thr Asn Ala Lys Ala Val Gly Glu Phe Gly Ile Asp 
                245                 250                 255     


Thr Ala Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly Arg Tyr Ser 
            260                 265                 270         


Leu Trp Ser Ala Ile Gly Leu Ser Ile Val Leu Ser Ile Gly Phe Asp 
        275                 280                 285             


Asn Phe Val Glu Leu Leu Ser Gly Ala His Ala Met Asp Lys His Phe 
    290                 295                 300                 


Ser Thr Thr Pro Ala Glu Lys Asn Leu Pro Val Leu Leu Ala Leu Ile 
305                 310                 315                 320 


Gly Ile Trp Tyr Asn Asn Phe Phe Gly Ala Glu Thr Glu Ala Ile Leu 
                325                 330                 335     


Pro Tyr Asp Gln Tyr Met His Arg Phe Ala Ala Tyr Phe Gln Gln Gly 
            340                 345                 350         


Asn Met Glu Ser Asn Gly Lys Tyr Val Asp Arg Asn Gly Asn Val Val 
        355                 360                 365             


Asp Tyr Gln Thr Gly Pro Ile Ile Trp Gly Glu Pro Gly Thr Asn Gly 
    370                 375                 380                 


Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys Met Val Pro 
385                 390                 395                 400 


Cys Asp Phe Ile Ala Pro Ala Ile Thr His Asn Pro Leu Ser Asp His 
                405                 410                 415     


His Gln Lys Leu Leu Ser Asn Phe Phe Ala Gln Thr Glu Ala Leu Ala 
            420                 425                 430         


Phe Gly Lys Ser Arg Glu Val Val Glu Gln Glu Tyr Arg Asp Gln Gly 
        435                 440                 445             


Lys Asp Pro Ala Thr Leu Asp Tyr Val Val Pro Phe Lys Val Phe Glu 
    450                 455                 460                 


Gly Asn Arg Pro Thr Asn Ser Ile Leu Leu Arg Glu Ile Thr Pro Phe 
465                 470                 475                 480 


Ser Leu Gly Ala Leu Ile Ala Leu Tyr Glu His Lys Ile Phe Thr Gln 
                485                 490                 495     


Gly Val Ile Leu Asn Ile Phe Thr Phe Asp Gln Trp Gly Val Glu Leu 
            500                 505                 510         


Gly Lys Gln Leu Ala Asn Arg Ile Leu Pro Glu Leu Lys Asp Asp Lys 
        515                 520                 525             


Glu Ile Ser Ser His Asp Ser Ser Thr Asn Gly Leu Ile Asn Arg Tyr 
    530                 535                 540                 


Lys Ala Trp Arg Gly 
545                 


<210>  11
<211>  491
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Ala Val Thr Gln Thr Ala Gln Ala Cys Asp Leu Val Ile Phe Gly 
1               5                   10                  15      


Ala Lys Gly Asp Leu Ala Arg Arg Lys Leu Leu Pro Ser Leu Tyr Gln 
            20                  25                  30          


Leu Glu Lys Ala Gly Gln Leu Asn Pro Asp Thr Arg Ile Ile Gly Val 
        35                  40                  45              


Gly Arg Ala Asp Trp Asp Lys Ala Ala Tyr Thr Lys Val Val Arg Glu 
    50                  55                  60                  


Ala Leu Glu Thr Phe Met Lys Glu Thr Ile Asp Glu Gly Leu Trp Asp 
65                  70                  75                  80  


Thr Leu Ser Ala Arg Leu Asp Phe Cys Asn Leu Asp Val Asn Asp Thr 
                85                  90                  95      


Ala Ala Phe Ser Arg Leu Gly Ala Met Leu Asp Gln Lys Asn Arg Ile 
            100                 105                 110         


Thr Ile Asn Tyr Phe Ala Met Pro Pro Ser Thr Phe Gly Ala Ile Cys 
        115                 120                 125             


Lys Gly Leu Gly Glu Ala Lys Leu Asn Ala Lys Pro Ala Arg Val Val 
    130                 135                 140                 


Met Glu Lys Pro Leu Gly Thr Ser Leu Ala Thr Ser Gln Glu Ile Asn 
145                 150                 155                 160 


Asp Gln Val Gly Glu Tyr Phe Glu Glu Cys Gln Val Tyr Arg Ile Asp 
                165                 170                 175     


His Tyr Leu Gly Lys Glu Thr Val Leu Asn Leu Leu Ala Leu Arg Phe 
            180                 185                 190         


Ala Asn Ser Leu Phe Val Asn Asn Trp Asp Asn Arg Thr Ile Asp His 
        195                 200                 205             


Val Glu Ile Thr Val Ala Glu Glu Val Gly Ile Glu Gly Arg Trp Gly 
    210                 215                 220                 


Tyr Phe Asp Lys Ala Gly Gln Met Arg Asp Met Ile Gln Asn His Leu 
225                 230                 235                 240 


Leu Gln Ile Leu Cys Met Ile Ala Met Ser Pro Pro Ser Asp Leu Ser 
                245                 250                 255     


Ala Asp Ser Ile Arg Asp Glu Lys Val Lys Val Leu Lys Ser Leu Arg 
            260                 265                 270         


Arg Ile Asp Arg Ser Asn Val Arg Glu Lys Thr Val Arg Gly Gln Tyr 
        275                 280                 285             


Thr Ala Gly Phe Ala Gln Gly Lys Lys Val Pro Gly Tyr Leu Glu Glu 
    290                 295                 300                 


Glu Gly Ala Asn Lys Ser Ser Asn Thr Glu Thr Phe Val Ala Ile Arg 
305                 310                 315                 320 


Val Asp Ile Asp Asn Trp Arg Trp Ala Gly Val Pro Phe Tyr Leu Arg 
                325                 330                 335     


Thr Gly Lys Arg Leu Pro Thr Lys Cys Ser Glu Val Val Val Tyr Phe 
            340                 345                 350         


Lys Thr Pro Glu Leu Asn Leu Phe Lys Glu Ser Trp Gln Asp Leu Pro 
        355                 360                 365             


Gln Asn Lys Leu Thr Ile Arg Leu Gln Pro Asp Glu Gly Val Asp Ile 
    370                 375                 380                 


Gln Val Leu Asn Lys Val Pro Gly Leu Asp His Lys His Asn Leu Gln 
385                 390                 395                 400 


Ile Thr Lys Leu Asp Leu Ser Tyr Ser Glu Thr Phe Asn Gln Thr His 
                405                 410                 415     


Leu Ala Asp Ala Tyr Glu Arg Leu Leu Leu Glu Thr Met Arg Gly Ile 
            420                 425                 430         


Gln Ala Leu Phe Val Arg Arg Asp Glu Val Glu Glu Ala Trp Lys Trp 
        435                 440                 445             


Val Asp Ser Ile Thr Glu Ala Trp Ala Met Asp Asn Asp Ala Pro Lys 
    450                 455                 460                 


Pro Tyr Gln Ala Gly Thr Trp Gly Pro Val Ala Ser Val Ala Met Ile 
465                 470                 475                 480 


Thr Arg Asp Gly Arg Ser Trp Asn Glu Phe Glu 
                485                 490     


<210>  12
<211>  468
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ser Lys Gln Gln Ile Gly Val Val Gly Met Ala Val Met Gly Arg 
1               5                   10                  15      


Asn Leu Ala Leu Asn Ile Glu Ser Arg Gly Tyr Thr Val Ser Ile Phe 
            20                  25                  30          


Asn Arg Ser Arg Glu Lys Thr Glu Glu Val Ile Ala Glu Asn Pro Gly 
        35                  40                  45              


Lys Lys Leu Val Pro Tyr Tyr Thr Val Lys Glu Phe Val Glu Ser Leu 
    50                  55                  60                  


Glu Thr Pro Arg Arg Ile Leu Leu Met Val Lys Ala Gly Ala Gly Thr 
65                  70                  75                  80  


Asp Ala Ala Ile Asp Ser Leu Lys Pro Tyr Leu Asp Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Thr Phe Phe Gln Asp Thr Ile Arg Arg Asn 
            100                 105                 110         


Arg Glu Leu Ser Ala Glu Gly Phe Asn Phe Ile Gly Thr Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Leu Lys Gly Pro Ser Ile Met Pro Gly Gly 
    130                 135                 140                 


Gln Lys Glu Ala Tyr Glu Leu Val Ala Pro Ile Leu Thr Lys Ile Ala 
145                 150                 155                 160 


Ala Val Ala Glu Asp Gly Glu Pro Cys Val Thr Tyr Ile Gly Ala Asp 
                165                 170                 175     


Gly Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly 
            180                 185                 190         


Asp Met Gln Leu Ile Ala Glu Ala Tyr Ser Leu Leu Lys Gly Gly Leu 
        195                 200                 205             


Asn Leu Thr Asn Glu Glu Leu Ala Gln Thr Phe Thr Glu Trp Asn Asn 
    210                 215                 220                 


Gly Glu Leu Ser Ser Tyr Leu Ile Asp Ile Thr Lys Asp Ile Phe Thr 
225                 230                 235                 240 


Lys Lys Asp Glu Asp Gly Asn Tyr Leu Val Asp Val Ile Leu Asp Glu 
                245                 250                 255     


Ala Ala Asn Lys Gly Thr Gly Lys Trp Thr Ser Gln Ser Ala Leu Asp 
            260                 265                 270         


Leu Gly Glu Pro Leu Ser Leu Ile Thr Glu Ser Val Phe Ala Arg Tyr 
        275                 280                 285             


Ile Ser Ser Leu Lys Asp Gln Arg Val Ala Ala Ser Lys Val Leu Ser 
    290                 295                 300                 


Gly Pro Gln Ala Gln Pro Ala Gly Asp Lys Ala Glu Phe Ile Glu Lys 
305                 310                 315                 320 


Val Arg Arg Ala Leu Tyr Leu Gly Lys Ile Val Ser Tyr Ala Gln Gly 
                325                 330                 335     


Phe Ser Gln Leu Arg Ala Ala Ser Glu Glu Tyr Asn Trp Asp Leu Asn 
            340                 345                 350         


Tyr Gly Glu Ile Ala Lys Ile Phe Arg Ala Gly Cys Ile Ile Arg Ala 
        355                 360                 365             


Gln Phe Leu Gln Lys Ile Thr Asp Ala Tyr Ala Glu Asn Pro Gln Ile 
    370                 375                 380                 


Ala Asn Leu Leu Leu Ala Pro Tyr Phe Lys Gln Ile Ala Asp Asp Tyr 
385                 390                 395                 400 


Gln Gln Ala Leu Arg Asp Val Val Ala Tyr Ala Val Gln Asn Gly Ile 
                405                 410                 415     


Pro Val Pro Thr Phe Ser Ala Ala Val Ala Tyr Tyr Asp Ser Tyr Arg 
            420                 425                 430         


Ala Ala Val Leu Pro Ala Asn Leu Ile Gln Ala Gln Arg Asp Tyr Phe 
        435                 440                 445             


Gly Ala His Thr Tyr Lys Arg Ile Asp Lys Glu Gly Val Phe His Thr 
    450                 455                 460                 


Glu Trp Leu Asp 
465             


<210>  13
<211>  175
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Ser Thr Thr Asn His Asp His His Ile Tyr Val Leu Met Gly Val 
1               5                   10                  15      


Ser Gly Ser Gly Lys Ser Ala Val Ala Ser Glu Val Ala His Gln Leu 
            20                  25                  30          


His Ala Ala Phe Leu Asp Gly Asp Phe Leu His Pro Arg Arg Asn Ile 
        35                  40                  45              


Glu Lys Met Ala Ser Gly Glu Pro Leu Asn Asp Asp Asp Arg Lys Pro 
    50                  55                  60                  


Trp Leu Gln Ala Leu Asn Asp Ala Ala Phe Ala Met Gln Arg Thr Asn 
65                  70                  75                  80  


Lys Val Ser Leu Ile Val Cys Ser Ala Leu Lys Lys His Tyr Arg Asp 
                85                  90                  95      


Leu Leu Arg Glu Gly Asn Pro Asn Leu Ser Phe Ile Tyr Leu Lys Gly 
            100                 105                 110         


Asp Phe Asp Val Ile Glu Ser Arg Leu Lys Ala Arg Lys Gly His Phe 
        115                 120                 125             


Phe Lys Thr Gln Met Leu Val Thr Gln Phe Glu Thr Leu Gln Glu Pro 
    130                 135                 140                 


Gly Ala Asp Glu Thr Asp Val Leu Val Val Asp Ile Asp Gln Pro Leu 
145                 150                 155                 160 


Glu Gly Val Val Ala Ser Thr Ile Glu Val Ile Lys Lys Gly Lys 
                165                 170                 175 


<210>  14
<211>  217
<212>  PRT
<213>  Escherichia coli

<400>  14

Met Asp Ile Ile Ser Val Ala Leu Lys Arg His Ser Thr Lys Ala Phe 
1               5                   10                  15      


Asp Ala Ser Lys Lys Leu Thr Pro Glu Gln Ala Glu Gln Ile Lys Thr 
            20                  25                  30          


Leu Leu Gln Tyr Ser Pro Ser Ser Thr Asn Ser Gln Pro Trp His Phe 
        35                  40                  45              


Ile Val Ala Ser Thr Glu Glu Gly Lys Ala Arg Val Ala Lys Ser Ala 
    50                  55                  60                  


Ala Gly Asn Tyr Val Phe Asn Glu Arg Lys Met Leu Asp Ala Ser His 
65                  70                  75                  80  


Val Val Val Phe Cys Ala Lys Thr Ala Met Asp Asp Val Trp Leu Lys 
                85                  90                  95      


Leu Val Val Asp Gln Glu Asp Ala Asp Gly Arg Phe Ala Thr Pro Glu 
            100                 105                 110         


Ala Lys Ala Ala Asn Asp Lys Gly Arg Lys Phe Phe Ala Asp Met His 
        115                 120                 125             


Arg Lys Asp Leu His Asp Asp Ala Glu Trp Met Ala Lys Gln Val Tyr 
    130                 135                 140                 


Leu Asn Val Gly Asn Phe Leu Leu Gly Val Ala Ala Leu Gly Leu Asp 
145                 150                 155                 160 


Ala Val Pro Ile Glu Gly Phe Asp Ala Ala Ile Leu Asp Ala Glu Phe 
                165                 170                 175     


Gly Leu Lys Glu Lys Gly Tyr Thr Ser Leu Val Val Val Pro Val Gly 
            180                 185                 190         


His His Ser Val Glu Asp Phe Asn Ala Thr Leu Pro Lys Ser Arg Leu 
        195                 200                 205             


Pro Gln Asn Ile Thr Leu Thr Glu Val 
    210                 215         


<210>  15
<211>  249
<212>  PRT
<213>  Francisella tularensis

<400>  15

Met Lys Ile Val Lys Asp Phe Ser Pro Lys Glu Tyr Ser Gln Lys Leu 
1               5                   10                  15      


Val Asn Trp Leu Ser Asp Ser Cys Met Asn Tyr Pro Ala Glu Gly Phe 
            20                  25                  30          


Val Ile Gly Leu Ser Gly Gly Ile Asp Ser Ala Val Ala Ala Ser Leu 
        35                  40                  45              


Ala Val Lys Thr Gly Leu Pro Thr Thr Ala Leu Ile Leu Pro Ser Asp 
    50                  55                  60                  


Asn Asn Gln His Gln Asp Met Gln Asp Ala Leu Glu Leu Ile Glu Met 
65                  70                  75                  80  


Leu Asn Ile Glu His Tyr Thr Ile Ser Ile Gln Pro Ala Tyr Glu Ala 
                85                  90                  95      


Phe Leu Ala Ser Thr Gln Ser Phe Thr Asn Leu Gln Asn Asn Arg Gln 
            100                 105                 110         


Leu Val Ile Lys Gly Asn Ala Gln Ala Arg Leu Arg Met Met Tyr Leu 
        115                 120                 125             


Tyr Ala Tyr Ala Gln Gln Tyr Asn Arg Ile Val Ile Gly Thr Asp Asn 
    130                 135                 140                 


Ala Cys Glu Trp Tyr Met Gly Tyr Phe Thr Lys Phe Gly Asp Gly Ala 
145                 150                 155                 160 


Ala Asp Ile Leu Pro Leu Val Asn Leu Lys Lys Ser Gln Val Phe Glu 
                165                 170                 175     


Leu Gly Lys Tyr Leu Asp Val Pro Lys Asn Ile Leu Asp Lys Ala Pro 
            180                 185                 190         


Ser Ala Gly Leu Trp Gln Gly Gln Thr Asp Glu Asp Glu Met Gly Val 
        195                 200                 205             


Thr Tyr Gln Glu Ile Asp Asp Phe Leu Asp Gly Lys Gln Val Ser Ala 
    210                 215                 220                 


Lys Ala Leu Glu Arg Ile Asn Phe Trp His Asn Arg Ser His His Lys 
225                 230                 235                 240 


Arg Lys Leu Ala Leu Thr Pro Asn Phe 
                245                 


<210>  16
<211>  473
<212>  PRT
<213>  Zymomonas mobilis

<400>  16

Met Ser Ser Glu Ser Ser Gln Gly Leu Val Thr Arg Leu Ala Leu Ile 
1               5                   10                  15      


Ala Ala Ile Gly Gly Leu Leu Phe Gly Tyr Asp Ser Ala Val Ile Ala 
            20                  25                  30          


Ala Ile Gly Thr Pro Val Asp Ile His Phe Ile Ala Pro Arg His Leu 
        35                  40                  45              


Ser Ala Thr Ala Ala Ala Ser Leu Ser Gly Met Val Val Val Ala Val 
    50                  55                  60                  


Leu Val Gly Cys Val Thr Gly Ser Leu Leu Ser Gly Trp Ile Gly Ile 
65                  70                  75                  80  


Arg Phe Gly Arg Arg Gly Gly Leu Leu Met Ser Ser Ile Cys Phe Val 
                85                  90                  95      


Ala Ala Gly Phe Gly Ala Ala Leu Thr Glu Lys Leu Phe Gly Thr Gly 
            100                 105                 110         


Gly Ser Ala Leu Gln Ile Phe Cys Phe Phe Arg Phe Leu Ala Gly Leu 
        115                 120                 125             


Gly Ile Gly Val Val Ser Thr Leu Thr Pro Thr Tyr Ile Ala Glu Ile 
    130                 135                 140                 


Ala Pro Pro Asp Lys Arg Gly Gln Met Val Ser Gly Gln Gln Met Ala 
145                 150                 155                 160 


Ile Val Thr Gly Ala Leu Thr Gly Tyr Ile Phe Thr Trp Leu Leu Ala 
                165                 170                 175     


His Phe Gly Ser Ile Asp Trp Val Asn Ala Ser Gly Trp Cys Trp Ser 
            180                 185                 190         


Pro Ala Ser Glu Gly Leu Ile Gly Ile Ala Phe Leu Leu Leu Leu Leu 
        195                 200                 205             


Thr Ala Pro Asp Thr Pro His Trp Leu Val Met Lys Gly Arg His Ser 
    210                 215                 220                 


Glu Ala Ser Lys Ile Leu Ala Arg Leu Glu Pro Gln Ala Asp Pro Asn 
225                 230                 235                 240 


Leu Thr Ile Gln Lys Ile Lys Ala Gly Phe Asp Lys Ala Met Asp Lys 
                245                 250                 255     


Ser Ser Ala Gly Leu Phe Ala Phe Gly Ile Thr Val Val Phe Ala Gly 
            260                 265                 270         


Val Ser Val Ala Ala Phe Gln Gln Leu Val Gly Ile Asn Ala Val Leu 
        275                 280                 285             


Tyr Tyr Ala Pro Gln Met Phe Gln Asn Leu Gly Phe Gly Ala Asp Thr 
    290                 295                 300                 


Ala Leu Leu Gln Thr Ile Ser Ile Gly Val Val Asn Phe Ile Phe Thr 
305                 310                 315                 320 


Met Ile Ala Ser Arg Val Val Asp Arg Phe Gly Arg Lys Pro Leu Leu 
                325                 330                 335     


Ile Trp Gly Ala Leu Gly Met Ala Ala Met Met Ala Val Leu Gly Cys 
            340                 345                 350         


Cys Phe Trp Phe Lys Val Gly Gly Val Leu Pro Leu Ala Ser Val Leu 
        355                 360                 365             


Leu Tyr Ile Ala Val Phe Gly Met Ser Trp Gly Pro Val Cys Trp Val 
    370                 375                 380                 


Val Leu Ser Glu Met Phe Pro Ser Ser Ile Lys Gly Ala Ala Met Pro 
385                 390                 395                 400 


Ile Ala Val Thr Gly Gln Trp Leu Ala Asn Ile Leu Val Asn Phe Leu 
                405                 410                 415     


Phe Lys Val Ala Asp Gly Ser Pro Ala Leu Asn Gln Thr Phe Asn His 
            420                 425                 430         


Gly Phe Ser Tyr Leu Val Phe Ala Ala Leu Ser Ile Leu Gly Gly Leu 
        435                 440                 445             


Ile Val Ala Arg Phe Val Pro Glu Thr Lys Gly Arg Ser Leu Asp Glu 
    450                 455                 460                 


Ile Glu Glu Met Trp Arg Ser Gln Lys 
465                 470             


<210>  17
<211>  400
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Pro Phe Val Lys Gly Phe Glu Pro Ile Ser Leu Arg Asp Thr Asn 
1               5                   10                  15      


Leu Phe Glu Pro Ile Lys Ile Gly Asn Thr Gln Leu Ala His Arg Ala 
            20                  25                  30          


Val Met Pro Pro Leu Thr Arg Met Arg Ala Thr His Pro Gly Asn Ile 
        35                  40                  45              


Pro Asn Lys Glu Trp Ala Ala Val Tyr Tyr Gly Gln Arg Ala Gln Arg 
    50                  55                  60                  


Pro Gly Thr Met Ile Ile Thr Glu Gly Thr Phe Ile Ser Pro Gln Ala 
65                  70                  75                  80  


Gly Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Asp Glu Gln Val Ala 
                85                  90                  95      


Glu Trp Lys Asn Ile Phe Leu Ala Ile His Asp Cys Gln Ser Phe Ala 
            100                 105                 110         


Trp Val Gln Leu Trp Ser Leu Gly Trp Ala Ser Phe Pro Asp Val Leu 
        115                 120                 125             


Ala Arg Asp Gly Leu Arg Tyr Asp Cys Ala Ser Asp Arg Val Tyr Met 
    130                 135                 140                 


Asn Ala Thr Leu Gln Glu Lys Ala Lys Asp Ala Asn Asn Leu Glu His 
145                 150                 155                 160 


Ser Leu Thr Lys Asp Asp Ile Lys Gln Tyr Ile Lys Asp Tyr Ile His 
                165                 170                 175     


Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His 
            180                 185                 190         


Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn 
        195                 200                 205             


Lys Arg Thr Asp Glu Tyr Gly Gly Thr Ile Glu Asn Arg Ala Arg Phe 
    210                 215                 220                 


Thr Leu Glu Val Val Asp Ala Leu Ile Glu Thr Ile Gly Pro Glu Arg 
225                 230                 235                 240 


Val Gly Leu Arg Leu Ser Pro Tyr Gly Thr Phe Asn Ser Met Ser Gly 
                245                 250                 255     


Gly Ala Glu Pro Gly Ile Ile Ala Gln Tyr Ser Tyr Val Leu Gly Glu 
            260                 265                 270         


Leu Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu 
        275                 280                 285             


Val Glu Pro Arg Val Thr Asp Pro Ser Leu Val Glu Gly Glu Gly Glu 
    290                 295                 300                 


Tyr Ser Glu Gly Thr Asn Asp Phe Ala Tyr Ser Ile Trp Lys Gly Pro 
305                 310                 315                 320 


Ile Ile Arg Ala Gly Asn Tyr Ala Leu His Pro Glu Val Val Arg Glu 
                325                 330                 335     


Gln Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile 
            340                 345                 350         


Ser Asn Pro Asp Leu Val Tyr Arg Leu Glu Glu Gly Leu Pro Leu Asn 
        355                 360                 365             


Lys Tyr Asp Arg Ser Thr Phe Tyr Thr Met Ser Ala Glu Gly Tyr Thr 
    370                 375                 380                 


Asp Tyr Pro Thr Tyr Glu Glu Ala Val Asp Leu Gly Trp Asn Lys Asn 
385                 390                 395                 400 


<210>  18
<211>  181
<212>  PRT
<213>  Ralstonia eutropha

<400>  18

Met Ala Thr Pro Ser Asp Thr Lys Thr Asp Gly Ala Asp Met Ile Tyr 
1               5                   10                  15      


Ile Leu Met Gly Val Ser Gly Ser Gly Lys Thr Thr Val Gly Gln Leu 
            20                  25                  30          


Leu Ala Gln Arg Leu Gly Cys Gly Phe His Asp Ala Asp Ala Phe His 
        35                  40                  45              


Ser Asp Ala Asn Lys Ala Lys Met His Ala Gly Val Pro Leu Thr Asp 
    50                  55                  60                  


Glu Asp Arg Trp Pro Trp Leu Ala Ala Met Arg Ala Ala Ile Asp Ala 
65                  70                  75                  80  


Ala Arg Ala Glu Gly Arg Thr His Val Phe Thr Cys Ser Ala Leu Arg 
                85                  90                  95      


Gln Ala Tyr Arg Asp Arg Leu Thr Pro Pro Asp Gly Gly Val Thr Phe 
            100                 105                 110         


Val Phe Met Lys Gly Asp Ala Ser Leu Ile Gly Thr Arg Leu Ser Ala 
        115                 120                 125             


Arg Thr Glu His Phe Phe Asn Pro Asp Leu Leu Gln Ser Gln Phe Asp 
    130                 135                 140                 


Thr Leu Glu Glu Pro Ser Asp Ala Leu Val Leu Asp Ile Arg Gln Ser 
145                 150                 155                 160 


Pro Glu Ala Leu Val Ala Thr Ile Leu Gln Ala Thr Val Pro Gln Gly 
                165                 170                 175     


Ala Gly Ala Ala Arg 
            180     


<210>  19
<211>  261
<212>  PRT
<213>  Bacillus subtilis

<400>  19

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  20
<211>  363
<212>  PRT
<213>  Pseudomonas putida

<400>  20

Met Ser Ala Leu Phe Glu Pro Tyr Thr Leu Lys Asp Val Thr Leu Arg 
1               5                   10                  15      


Asn Arg Ile Ala Ile Pro Pro Met Cys Gln Tyr Met Ala Glu Asp Gly 
            20                  25                  30          


Leu Ile Asn Asp Trp His Gln Val His Tyr Ala Ser Met Ala Arg Gly 
        35                  40                  45              


Gly Ala Gly Leu Leu Val Val Glu Ala Thr Ala Val Ala Pro Glu Gly 
    50                  55                  60                  


Arg Ile Thr Pro Gly Cys Ala Gly Ile Trp Ser Asp Ala His Ala Gln 
65                  70                  75                  80  


Ala Phe Val Pro Val Val Gln Ala Ile Lys Ala Ala Gly Ser Val Pro 
                85                  90                  95      


Gly Ile Gln Ile Ala His Ala Gly Arg Lys Ala Ser Ala Asn Arg Pro 
            100                 105                 110         


Trp Glu Gly Asp Asp His Ile Gly Ala Asp Asp Ala Arg Gly Trp Glu 
        115                 120                 125             


Thr Ile Ala Pro Ser Ala Ile Ala Phe Gly Ala His Leu Pro Asn Val 
    130                 135                 140                 


Pro Arg Ala Met Thr Leu Asp Asp Ile Ala Arg Val Lys Gln Asp Phe 
145                 150                 155                 160 


Val Asp Ala Ala Arg Arg Ala Arg Asp Ala Gly Phe Glu Trp Ile Glu 
                165                 170                 175     


Leu His Phe Ala His Gly Tyr Leu Gly Gln Ser Phe Phe Ser Glu His 
            180                 185                 190         


Ser Asn Lys Arg Thr Asp Ala Tyr Gly Gly Ser Phe Asp Asn Arg Ser 
        195                 200                 205             


Arg Phe Leu Leu Glu Thr Leu Ala Ala Val Arg Glu Val Trp Pro Glu 
    210                 215                 220                 


Asn Leu Pro Leu Thr Ala Arg Phe Gly Val Leu Glu Tyr Asp Gly Arg 
225                 230                 235                 240 


Asp Glu Gln Thr Leu Glu Glu Ser Ile Glu Leu Ala Arg Arg Phe Lys 
                245                 250                 255     


Ala Gly Gly Leu Asp Leu Leu Ser Val Ser Val Gly Phe Thr Ile Pro 
            260                 265                 270         


Glu Thr Asn Ile Pro Trp Gly Pro Ala Phe Met Gly Pro Ile Ala Glu 
        275                 280                 285             


Arg Val Arg Arg Glu Ala Lys Leu Pro Val Thr Ser Ala Trp Gly Phe 
    290                 295                 300                 


Gly Thr Pro Gln Leu Ala Glu Ala Ala Leu Gln Ala Asn Gln Leu Asp 
305                 310                 315                 320 


Leu Val Ser Val Gly Arg Ala His Leu Ala Asp Pro His Trp Ala Tyr 
                325                 330                 335     


Phe Ala Ala Lys Glu Leu Gly Val Glu Lys Ala Ser Trp Thr Leu Pro 
            340                 345                 350         


Ala Pro Tyr Ala His Trp Leu Glu Arg Tyr Arg 
        355                 360             


<210>  21
<211>  267
<212>  PRT
<213>  Corynebacterium aquaticum

<400>  21

Met Thr Ala Thr Ser Ser Pro Thr Thr Arg Phe Thr Asp Arg Val Val 
1               5                   10                  15      


Leu Ile Thr Gly Gly Gly Ser Gly Leu Gly Arg Ala Thr Ala Val Arg 
            20                  25                  30          


Leu Ala Ala Glu Gly Ala Lys Leu Ser Leu Val Asp Val Ser Ser Glu 
        35                  40                  45              


Gly Leu Glu Ala Ser Lys Ala Ala Val Leu Glu Thr Ala Pro Asp Ala 
    50                  55                  60                  


Glu Val Leu Thr Thr Val Ala Asp Val Ser Asp Glu Ala Gln Val Glu 
65                  70                  75                  80  


Ala Tyr Val Thr Ala Thr Thr Glu Arg Phe Gly Arg Ile Asp Gly Phe 
                85                  90                  95      


Phe Asn Asn Ala Gly Ile Glu Gly Lys Gln Asn Pro Thr Glu Ser Phe 
            100                 105                 110         


Thr Ala Ala Glu Phe Asp Lys Val Val Ser Ile Asn Leu Arg Gly Val 
        115                 120                 125             


Phe Leu Gly Leu Glu Lys Val Leu Lys Ile Met Arg Glu Gln Gly Ser 
    130                 135                 140                 


Gly Met Val Val Asn Thr Ala Ser Val Gly Gly Ile Arg Gly Ile Gly 
145                 150                 155                 160 


Asn Gln Ser Gly Tyr Ala Ala Ala Lys His Gly Val Val Gly Leu Thr 
                165                 170                 175     


Arg Asn Ser Ala Val Glu Tyr Gly Arg Tyr Gly Ile Arg Ile Asn Ala 
            180                 185                 190         


Ile Ala Pro Gly Ala Ile Trp Thr Pro Met Val Glu Asn Ser Met Lys 
        195                 200                 205             


Gln Leu Asp Pro Glu Asn Pro Arg Lys Ala Ala Glu Glu Phe Ile Gln 
    210                 215                 220                 


Val Asn Pro Ser Lys Arg Tyr Gly Glu Ala Pro Glu Ile Ala Ala Val 
225                 230                 235                 240 


Val Ala Phe Leu Leu Ser Asp Asp Ala Ser Tyr Val Asn Ala Thr Val 
                245                 250                 255     


Val Pro Ile Asp Gly Gly Gln Ser Ala Ala Tyr 
            260                 265         


<210>  22
<211>  249
<212>  PRT
<213>  Ralstonia solanacearum

<400>  22

Met Tyr Arg Leu Leu Asn Lys Thr Ala Val Ile Thr Gly Gly Asn Ser 
1               5                   10                  15      


Gly Ile Gly Leu Ala Thr Ala Lys Arg Phe Val Ala Glu Gly Ala Tyr 
            20                  25                  30          


Val Phe Ile Val Gly Arg Arg Arg Lys Glu Leu Glu Gln Ala Ala Ala 
        35                  40                  45              


Glu Ile Gly Arg Asn Val Thr Ala Val Lys Ala Asp Val Thr Lys Leu 
    50                  55                  60                  


Glu Asp Leu Asp Arg Leu Tyr Ala Ile Val Arg Glu Gln Arg Gly Ser 
65                  70                  75                  80  


Ile Asp Val Leu Phe Ala Asn Ser Gly Ala Ile Glu Gln Lys Thr Leu 
                85                  90                  95      


Glu Glu Ile Thr Pro Glu His Tyr Asp Arg Thr Phe Asp Val Asn Val 
            100                 105                 110         


Arg Gly Leu Ile Phe Thr Val Gln Lys Ala Leu Pro Leu Leu Arg Asp 
        115                 120                 125             


Gly Gly Ser Val Ile Leu Thr Ser Ser Val Ala Gly Val Leu Gly Leu 
    130                 135                 140                 


Gln Ala His Asp Thr Tyr Ser Ala Ala Lys Ala Ala Val Arg Ser Leu 
145                 150                 155                 160 


Ala Arg Thr Trp Thr Thr Glu Leu Lys Gly Arg Ser Ile Arg Val Asn 
                165                 170                 175     


Ala Val Ser Pro Gly Ala Ile Asp Thr Pro Ile Ile Glu Asn Gln Val 
            180                 185                 190         


Ser Thr Gln Glu Glu Ala Asp Glu Leu Arg Ala Lys Phe Ala Ala Ala 
        195                 200                 205             


Thr Pro Leu Gly Arg Val Gly Arg Pro Glu Glu Leu Ala Ala Ala Val 
    210                 215                 220                 


Leu Phe Leu Ala Ser Asp Asp Ser Ser Tyr Val Ala Gly Ile Glu Leu 
225                 230                 235                 240 


Phe Val Asp Gly Gly Leu Thr Gln Val 
                245                 


<210>  23
<211>  1048
<212>  PRT
<213>  Bacillus megaterium

<400>  23

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Gly Leu Lys Phe Val Arg Asp 
65                  70                  75                  80  


Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Glu 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Ser Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Ser Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  24
<211>  471
<212>  PRT
<213>  Francisella tularensis

<400>  24

Met Ser Phe Asp Asn Leu Leu Leu Met Thr Asp Ser Tyr Lys His Ser 
1               5                   10                  15      


His Arg Tyr Gln Tyr Pro Arg Asp Thr His Tyr Leu His Phe Tyr Leu 
            20                  25                  30          


Glu Ser Arg Gly Thr Ala Asn Lys Asp Leu Gly Asn Tyr Thr Lys Phe 
        35                  40                  45              


Phe Gly Leu Gln Tyr Tyr Val Lys Lys Tyr Leu Ser Gln Pro Ile Thr 
    50                  55                  60                  


Gln Gln Met Ile Asp Asp Ala Glu Lys Ile Leu Leu Ala His Gly Leu 
65                  70                  75                  80  


Pro Phe Tyr Arg Ser Gly Phe Glu Lys Ile Leu Asn Asn Tyr Asn Gly 
                85                  90                  95      


Tyr Leu Pro Ile Arg Ile Arg Ala Val Arg Glu Gly Ser Leu Ile Pro 
            100                 105                 110         


Leu His Asn Val Leu Met Thr Ile Glu Ser Thr Asp Glu Glu Leu Phe 
        115                 120                 125             


Trp Leu Pro Gly Phe Val Glu Thr Leu Leu Leu Lys Val Trp Tyr Pro 
    130                 135                 140                 


Thr Thr Val Ala Thr Ile Ser Phe Asn Ile Lys Gln Leu Ile Lys Arg 
145                 150                 155                 160 


Tyr Leu Leu Glu Thr Ala Asp Ser Leu Asp Lys Leu Asp Phe Met Leu 
                165                 170                 175     


His Asp Phe Gly Tyr Arg Gly Val Ser Ser Glu Glu Ser Ala Gly Ile 
            180                 185                 190         


Gly Gly Ala Ala His Leu Thr Asn Phe Leu Gly Thr Asp Thr Leu Ala 
        195                 200                 205             


Ala Leu His Val Cys Lys Glu Phe Tyr Ala Glu Asp Met Ala Gly Phe 
    210                 215                 220                 


Ser Ile Pro Ala Ser Glu His Ser Thr Met Thr Ser Trp Gly Val Gly 
225                 230                 235                 240 


Thr Glu Cys Glu Arg Glu Ala Phe Glu Asn Met Ile Ala Gln Phe Gly 
                245                 250                 255     


Asp Ser Ser Val Leu Tyr Ala Cys Val Ser Asp Ser Trp Asp Phe Lys 
            260                 265                 270         


Lys Ala Ile Gln Thr Trp Val Asp Leu Lys Asp Arg Val Thr Ala Lys 
        275                 280                 285             


Lys Ala Asn Leu Val Ile Arg Pro Asp Ser Gly Asp Ala Val Asp Asn 
    290                 295                 300                 


Ile Leu Tyr Ala Leu Tyr Glu Leu Asp Lys Gly Tyr Gly Ser Arg Leu 
305                 310                 315                 320 


Asn Ser Lys Gly Tyr Lys Val Leu Asn Asn Val Ala Leu Ile Gln Gly 
                325                 330                 335     


Asp Ser Val Ser Ile Ser Leu Ala Lys Lys Val Leu Glu Ala Met Lys 
            340                 345                 350         


Ile Gln Gly Tyr Ser Ala Glu Asn Ile Ala Phe Gly Met Gly Gly Ala 
        355                 360                 365             


Leu Leu Gln Gly Asn Tyr Glu Ser Ser Ile Asn Arg Asp Ser Phe Lys 
    370                 375                 380                 


Phe Ala Ile Lys Cys Ser Ala Ile Met Arg Gly Asn Thr Leu Ile Gly 
385                 390                 395                 400 


Val Lys Lys Glu Pro Ile Thr Asp Leu Ala Lys Lys Ser Lys Gln Gly 
                405                 410                 415     


Arg Leu Asp Leu Ile Lys Asp Ala Lys Gly Asn Tyr Lys Thr Ile Val 
            420                 425                 430         


Leu Asp Asp Ser Tyr Ala Leu Gly Glu Tyr His Pro Glu Ser Gln Leu 
        435                 440                 445             


Gln Thr Tyr Tyr Asp Asn Gly Glu Ile Lys Phe Glu Gln Ser Leu Ala 
    450                 455                 460                 


Gln Ile Arg Asn Tyr Thr Asn 
465                 470     


<210>  25
<211>  783
<212>  DNA
<213>  Bacillus subtilis

<400>  25
atgtatccgg atctgaaagg taaggtggtg gcaatcaccg gtgcagcaag cggcctgggc       60

aaagctatgg ctatccgctt tggtaaagag caggcaaaag tggtgatcaa ttactattct      120

aataaacagg acccgaacga agtgaaagaa gaagtgatta aagccggcgg cgaagcagtg      180

gttgttcagg gtgacgtgac caaagaagaa gacgtgaaga acattgtgca gaccgccatc      240

aaggagtttg gcacactgga tatcatgatc aacaacgccg gtctggagaa tccggtgccg      300

agccatgaaa tgccgctgaa ggactgggac aaagtgatcg gcaccaatct gacaggcgca      360

tttctgggca gccgcgaggc aatcaaatat tttgttgaaa atgatatcaa aggtaatgtt      420

attaatatga gcagcgtgca cgaagtgatt ccgtggccgc tgtttgtgca ttatgcagcc      480

agcaaaggcg gcattaaact gatgaccgag accctggccc tggaatatgc cccgaaaggc      540

attcgcgtga acaatattgg tccgggtgcc atcaataccc cgatcaacgc cgaaaagttt      600

gccgacccga aacagaaagc cgatgtggag agcatgattc cgatgggcta catcggcgaa      660

ccggaagaaa ttgcagcagt ggccgcctgg ctggccagta aggaagcaag ctatgtgacc      720

ggcattaccc tgtttgccga tggcggcatg acacagtatc cgagctttca ggcaggccgc      780

ggt                                                                    783


