                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
 
<120>  CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS REPLICON PARTICLES AND USE 
       THEREOF

<130>  8618-101629-02

<150>  62/780,098
<151>  2018-12-14

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  4576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pT7-S)

<400>  1
gctgaaagga ggaactatat ccggatcgag atcctctagg tacaagccta attgtgtagc       60

atctggctta ctgaagcaga ccctatcatc tctctcgtaa actgccgtca gagtcggttt      120

ggttggacga accttctgag tttctggtaa cgccgtcccg cacccggaaa tggtcagcga      180

accaatcagc agggtcatcg ctagccagat cctctacgcc ggacgcatcg tggccggcat      240

caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc gacatcaccg atggggaaga      300

tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc gtgggtatgg tggcaggccc      360

cgtggccggg ggactgttgg gcgccatctc cttgcaccat tccttgcggc ggcggtgctc      420

aacggcctca acctactact gggctgcttc ctaatgcagg agtcgcataa gggagagcgt      480

cgatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac      540

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca      600

gacaagctgt gacaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa      660

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt      720

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa      780

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta      840

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag      900

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca      960

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     1020

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     1080

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     1140

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     1200

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     1260

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     1320

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     1380

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     1440

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     1500

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     1560

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     1620

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     1680

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     1740

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     1800

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     1860

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     1920

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     1980

atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     2040

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     2100

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     2160

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     2220

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     2280

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     2340

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     2400

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     2460

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     2520

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     2580

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg     2640

cgcgttggcc gattcattaa tgcaggggga tctcgatccc gcgaaattaa tacgactcac     2700

tatagtctca aagaaacacg tgccgcttac gcccacagtg ttctcttgag tgttagcaga     2760

atggaaaaca agatcgaggt gaataacaaa gatgagatga acaggtggtt tgaagagttc     2820

aaaaaaggaa atggacttgt ggacaccttc acaaactcct attccttttg cgagagtgtt     2880

cccaatttgg acaggtttgt gtttcagatg gccagtgcca ccgatgatgc acagaaggac     2940

tccatctacg catctgctct ggtggaggca acaaagtttt gtgcacctat atatgagtgc     3000

gcatgggtta gctccactgg cattgtaaaa aagggacttg aatggttcga gaaaaatgca     3060

ggaaccatta agtcctggga tgaaagttat actgagctaa aggtcgacgt cccgaaaata     3120

gagcagctta ccggttacca acaagctgcc ttgaagtgga gaaaagacat aggtttccgt     3180

gtcaatgcca acacagcagc tctgagcaac aaagtcctcg cagaatacaa agtccctggt     3240

gagattgtga tgtctgtcaa agagatgctg tcagacatga ttaggagaag gaacctgatt     3300

ctaaacaggg gtggtgatga gaacccacgt ggcccagtga gccatgagca tgtagactgg     3360

tgcagggagt ttgtcaaagg caaatacatc atggccttca acccaccatg gggggacatc     3420

aacaagtcag gccgttcagg aatagcactt gttgcaacag gccttgctaa gcttgcagag     3480

actgaaggaa agggaatatt tgatgaagcc aaaaagactg tggaggccct caacgggtat     3540

ctggacaagc ataaggacga agttgataga gcaagcgccg acagcatgat aacaaacctt     3600

cttaagcata ttgccaaggc acaggagctc tataaaaatt catctgcact tcgtgcacaa     3660

agcgcacaga ttgacactgc tttcagctca tactattggc tttacaaggc tggcgtgact     3720

cctgaaacct tcccgacggt gtcacagttc ctctttgagc tagggaaaca gccaagaggt     3780

accaagaaaa tgaagaaggc tcttctgagc accccaatga agtgggggaa gaagctttat     3840

gagctctttg ccgatgattc tttccagcag aacaggattt acatgcatcc tgccgtgctt     3900

acagctggta gaatcagtga aatgggagtc tgctttggga caatccctgt ggccaatcct     3960

gatgatgctg cccaaggatc tggacacact aagtctattc tcaacctccg taccaacact     4020

gagaccaata atccgtgtgc caaaaccatc gtcaagctat ttgaagttca aaaaacaggg     4080

ttcaacattc aggacatgga catagtggcc tctgagcact tgctacacca atcccttgtt     4140

ggcaagcaat ccccattcca gaacgcctac aacgtcaagg gcaatgccac cagtgctaac     4200

atcatttaaa atacaaactg ctctgtactc aacttccttc cttctgaacc gccatccata     4260

attgcaatac ttaatcatgc ttttttactt gcttatgtaa ccttatttta ttaacctttc     4320

tctattttct cttgttttaa acacttaaag ggctgtgcgg caacgatatc tttgagaggg     4380

tcggcatggc atctccacct cctcgcggtc cgacctgggc atccgaagga ggacgtcgtc     4440

cactcggatg gctaagggag agctcggatc cggctgctaa caaagcccga aaggaagctg     4500

agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg     4560

tcttgagggg tttttt                                                     4576


<210>  2
<211>  15064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pT7-L)

<400>  2
gctgaaagga ggaactatat ccggatcgag atcctctagg tacaagccta attgtgtagc       60

atctggctta ctgaagcaga ccctatcatc tctctcgtaa actgccgtca gagtcggttt      120

ggttggacga accttctgag tttctggtaa cgccgtcccg cacccggaaa tggtcagcga      180

accaatcagc agggtcatcg ctagccagat cctctacgcc ggacgcatcg tggccggcat      240

caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc gacatcaccg atggggaaga      300

tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc gtgggtatgg tggcaggccc      360

cgtggccggg ggactgttgg gcgccatctc cttgcaccat tccttgcggc ggcggtgctc      420

aacggcctca acctactact gggctgcttc ctaatgcagg agtcgcataa gggagagcgt      480

cgatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac      540

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca      600

gacaagctgt gacaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa      660

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt      720

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa      780

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta      840

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag      900

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca      960

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     1020

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     1080

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     1140

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     1200

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     1260

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     1320

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     1380

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     1440

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     1500

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     1560

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     1620

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     1680

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     1740

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     1800

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     1860

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     1920

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     1980

atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     2040

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     2100

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     2160

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     2220

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     2280

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     2340

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     2400

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     2460

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     2520

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     2580

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg     2640

cgcgttggcc gattcattaa tgcaggggga tctcgatccc gcgaaattaa tacgactcac     2700

tatagtctca aagacatcaa tccccccgtt acccacgtta acacagagag ctctagtagt     2760

ggtctttcct tttgtgaaac catggacttc ttgagaagcc ttgactggac tcaagtgatt     2820

gctggtcaat atgtgtccaa ccctaggttc aacatttctg attattttga gattgtgcgg     2880

cagcctggtg atgggaactg cttctatcac agcatagctg agttaaccat gcctaacaaa     2940

acagatcact catatcatta catcaaacgc ctaaccgagt cggcagcacg gaagtattac     3000

caagaggagc ctgaagccag acttgttggc ctgagcctgg aagattacct caagaggatg     3060

ctgtctgaca acgagtgggg atcaactcta gaagcatcta tgttggctaa agaaatgggc     3120

attaccatca tcatttggac tgttgctgcc agtgatgaag tggaagcagg tataaagttc     3180

ggagacggtg atgtgtttac agctgtgaac cttttgcact ctggacaaac acactttgat     3240

gcgctcagaa tacttccgca gtttgaaaca gacacaagag aggccttgag cttgatggac     3300

agggttatag ctgtggatca gttgacatca tcttctagtg atgaactgca agactatgaa     3360

gaccttgcct tggcactcac aagcgcagaa gaatcaaata gacggtcaag cttggatgag     3420

gtcacattgt ccaagaagca agcagagata ctaaggcaaa aagcatctca gttgtctaaa     3480

ttggttaata aaagtcagaa cataccgacc agagtcggta gagtcttgga ttgcatgttc     3540

aactgcaaat tatgtgttga gatatcagct gacactttaa ttctgaggcc agaatcaaaa     3600

gagaaaatcg gtgaaatcat gtcattgcgg cagttggggc ataaactgct gacacgagac     3660

aaacagatta agcaagagtt ctccagaatg aaactctacg tcactaaaga tttgcttgac     3720

catctagacg ttggtgggct cttgagggct gctttccctg gaacaggaat agaaaggcat     3780

atgcagctgc tacactctga gatgatactg gacatctgca ctgtatcact tggtgtcatg     3840

ctgtcaacat tcttatatgg ttctaataat aaaaacaaga agaaattcat taccaactgt     3900

ctgctcagca cagccctatc cggaaagaag gtgtataaag ttctcggcaa cctaggaaat     3960

gaactgttgt acaaggcacc tagaaaggcc ttagcaactg tctgcagtgc cttgtttggg     4020

aagcagataa acaaacttca gaattgcttc aggaccataa gccctgtcag cttacttgca     4080

ttgagaaatc tagactttga ttgtctcagt gtgcaagact ataatggtat gatagaaaac     4140

atgtctaaat tagacaacac tgatgttgaa ttcaaccaca gggagatagc tgatctcaac     4200

caattaactt ctcggctcat cacattaaga aaggagaaag acactgacct cctcaaacaa     4260

tggtttcctg aaagtgacct cacccgcaga agcatcagga atgctgcaaa cgcggaggaa     4320

tttgtcatat ctgagttctt taagaagaag gacattatga aattcatcag cacttcaggc     4380

agagcaatga gtgcaggcaa gattggtaat gtcctatcct atgcacataa tctttatttg     4440

agtaagtcaa gcctaaatat gacctctgaa gacatctcac agcttttgat cgagattaag     4500

cgactgtatg ctttacaaga agattctgaa gtggagccga tagccataat ttgtgatggc     4560

atagaaagca acatgaaaca gttatttgct atattgcctc ctgactgtgc aagagagtgt     4620

gaagtcctct tcgatgacat aagaaattct ccaacacaca gcacagcctg gaagcatgca     4680

ctccgattaa aagggactgc atacgaaggt ctgtttgcaa attgttacgg ctggcaatac     4740

attccggaag acattaaacc aagcctgacc atgttgatac agactttgtt tcctgacaag     4800

ttcgaagatt tcctggatcg aacccagttg catccggagt tcagagacct gactcccgac     4860

ttttcgctca cacaaaaggt tcactttaaa agaaatcaga tacccagtgt cgaaaatgtg     4920

caaatctcca ttgatgcgac gttgcctgaa tctgtggaag cagtaccagt gacagaaaga     4980

aagatgttcc cccttcctga gactccgcta agtgaggtgc attcaataga gcgtataatg     5040

gaaaacttta ctcgcctcat gcatggagga agactttcga ccaagaaaag agatggagat     5100

ccggcggaac agggcaacca gcagagtatc actgaacacg agagttccag catctctgcc     5160

tttaaagact acggagagag agggatagtc gaggaaaatc acatgaagtt tagtggagaa     5220

gatcagctag agacaaggca gctgttgttg gtggaagttg gttttcaaac tgacatcgat     5280

gggaaaataa ggacagacca caagaagtgg aaagacatat taaagctatt agagctacta     5340

ggaatcaagt gctcattcat tgcctgtgca gattgctcat ccacaccacc agacagatgg     5400

tggattacgg aggacagagt gcgagtccta aaaaattcag tcagcttctt gttcaataaa     5460

ctctccagaa actcacctac agaagtaact gacatagttg ttggagctat aagtactcaa     5520

aaggttagaa gttatctaaa ggcaggaact gcaacaaaaa cccctgtgtc gactaaagac     5580

gttctggaga cttgggaaaa gatgaaggag cacatactca acagaccaac aggactgaca     5640

ctgcccacca gtttggaaca ggcaatgcgc aaaggactgg tcgaaggtgt ggtcatctcc     5700

aaggaaggtt ctgagtcatg tatcaatatg ttgaaggaaa atttggaccg aataactgac     5760

gaattcgagc gaacaaaatt taaacatgaa cttactcaga atattaccac aagtgagaag     5820

atgctattga gttggttgag tgaagacatc aaatcatcga gatgtggtga gtgcctctca     5880

aatataaaga aagccgttga tgaaactgcc aatctatcag aaaagattga gctgctcgct     5940

tataatctgc aactcaccaa tcactgcagc aactgtcacc ccaatggtgt aaacattagt     6000

aacacttcta atgtgtgcaa gagatgcccc aagattgaag tggttagcca ttgtgaaaat     6060

aaaggctttg aggacagcaa tgaatgctta acagacctag ataggcttgt taggctcaca     6120

ttaccaggga aaactgagaa ggagagaaga gtcaaacgta atgtggaata tcttataaaa     6180

ctgatgatga gcatgtcagg cattgattgt ataaaatatc ccacagggca gcttatcacc     6240

catggaagag tgagtgcaaa acataacgat gggaacctga aagatagaag cgatgacgac     6300

caaagactag ctgagaagat agacactgtt aggaaagagc tttcagaatc taaactgaaa     6360

gattattcaa cttatgcaag gggagtgata tcaaattcac taaaaaacct ctcaaggcaa     6420

ggtaaatcaa agtgttctgt gccaagatct tggctcgaga aagtactgtt tgacctgaag     6480

gtgcctacta aggacgaaga agtgcttata aacatcagaa actcattgaa agctagatcc     6540

gagtttgtta gaaataacga taaactactc ataaggtcaa aagaagaact aaaaaaatgt     6600

ttcgatgtgc agtcttttaa attgaaaaaa aacaagcaac ctgtgccctt tcaggttgac     6660

tgtatattgt tcaaagaagt ggcagctgaa tgcatgaaga ggtacattgg cacaccttat     6720

gagggaattg tagacacctt agtttctctg attaatgtgt taacaaggtt tacttggttc     6780

caggaagtgg tgctatatgg taaaatatgt gagaccttcc taagatgctg cacagaattt     6840

aataggtcag gggtcaaact ggttaagata aggcactgta acattaacct atcagtcaaa     6900

ttgccatcaa ataagaaaga gaatatgtta tgttgtctat atagtggaaa catggagctc     6960

ttgcaaggac ctttctattt gaacaggaga caagctgtcc ttggttcttc atacctttac     7020

attgtcatta cactttacat acaagtgctg cagcagtaca ggtgtctaga agttataaac     7080

agtgtgagtg aaaaaacatt gcaagacatt gaaaatcatt ccatgactct actagaagat     7140

tcattcaggg aaatcacttt tgctcttgaa ggtaggtttg aagaatctta taaaatacga     7200

acctcgaggt gcagagccag tgggaatttt ctgaacagga gcagtagaga ccactttata     7260

agcgttgttt caggcttgaa cctagtttat ggcttcctca taaaagataa cttactagcc     7320

aactctcagc aacagaacaa acaactacag atgcttcgtt ttggcatgct tgcagggctt     7380

agtaggcttg tttgtcctaa tgagctagga aagaaatttt caacgagctg tagaagaatt     7440

gaagacaaca ttgcaaggct ttacctgcag acatccattt actgttcagt cagggatgtg     7500

gaggacaatg ttaagcactg gaaacaaaga gatctatgtc ctgaagtaac cattccatgc     7560

tttacagtct atggaacctt tgtcaacagc gatagacaac tgatctttga catttacaat     7620

gtgcatatat ataataaaga aatggacaac tttgatgaag gatgtatcag cgtcttggaa     7680

gaaacagcag aaaggcacat gctttgggaa ctcgatctga tgaattcact ttgttctgac     7740

gaaaaaaaag atactagaac cgcaagacta ttactaggct gcccaaatgt gaggaaagca     7800

gcaaacagag aagggaagaa gctgttgaag ttaaacagtg acacatccac agacacacag     7860

agcattgctt ctgaagtgtc ggacagaagg tcttatagtt caagtaagag tagaatccgt     7920

agtatatttg gtagatacaa ctctcagaag aaaccatttg aattaaggtc aggtcttgag     7980

gttttcaatg atcctttcaa tgattatcag caagcaataa cggacatttg ccaattttct     8040

gagtacacac caaacaaaga aagcattttg aaagactgtc ttcaaatcat acgaaaaaac     8100

cctagccaca caatgggttc ttttgagctg atccaggcaa tctcagagtt cggcatgagc     8160

aagtttcctc ccgaaaatat agacaaagca agaagggatc cgaagaactg ggttagcatc     8220

tctgaagtaa ccgaaacaac aagtatagtt gcatcaccta gaactcatat gatgctcaag     8280

gattgtttta aaattatact aggtactgag aataagaaga tagtcaaaat gcttcgaggt     8340

aagctaaaga aactcggtgc tatctcaaca aacatagaga tcgggaaaag ggattgccta     8400

gatctactca gcacagtaga tgggctaaca gaccagcaga aagaaaatat tgtaaatggg     8460

atatttgagc cctcaaagtt atccttctac cattggaagg aattggtcaa aaaaaacatt     8520

gatgaagttt tacttactga agatggaaat ctgatcttct gctggctgaa aacaatctcc     8580

tcttcagtca aaggaagcct aaagaagaga ctcaaattca tgaatataca ttctccagaa     8640

ttgatgccgg aaaactgtct cttttctagt gaggaattca atgagttaat taagttgaag     8700

aaactcctcc tcaatgaaca acaagatgaa caggagctga aacaagatct tttgatatct     8760

tcttggatca agtgcataac agcttgcaag gattttgcaa gcatcaatga caagattcag     8820

aagttcattt accacctgtc tgaagagcta tatgacataa ggctgcagca tctggaactg     8880

tcaaagctta agcaagagca ccctagtgtc agcttcacaa aagaagaagt cttaataaag     8940

cggctggaga aaaatttcct taagcagcat aatttagaga ttatggaaac tgtgaatctt     9000

gtattctttg cagccctctc agctccctgg tgcttacact ataaagcact agagtcttat     9060

ttggtgagac atccagaaat acttgactgt ggatctaagg aggactgcaa actcaccttg     9120

cttgatctgt cagtttctaa gctcttggtt tgtttgtatc aaaaagatga tgaggagctg     9180

ataaatagct caagtttgaa acttgggttt ttagtgaaat atgttgtcac cttgttcaca     9240

tccaatggtg aacctttttc actcagtctc aatgacgggg gtttggatct tgatttacac     9300

aagactactg acgaaaagtt actacatcaa acaaagatag tttttgctaa aattggttta     9360

tctgggaaca gttatgactt tatctggact acccaaatga tagcaaacag caattttaac     9420

gtctgcaaaa gattaacggg aaggagtact ggggaaaggc tccctagaag cgttagaagc     9480

aaggtcatat atgagatggt aaaattagtg ggagaaacag gcatggcaat actacaacaa     9540

ttagcttttg cacaagcact aaattatgag caccgcttct atgcggtctt agcacctaaa     9600

gcgcaactag gaggagcaag agatttgtta gtgcaagaga ctgggactaa agtcatgcat     9660

gcaaccactg aaatgtttag tagaaatctt ttaaaaacaa catcagatga tggcctcaca     9720

aacccacatc ttaaagaaac aatccttaat gtgggattag actgtcttgc taacatgcga     9780

aatcttgacg gtaagcccat aagtgaaggt agtaacttgg tcaatttcta caaagtcata     9840

tgtatctcgg gtgataatac caagtggggc ccgatacact gctgttcttt cttttctggc     9900

atgatgcaac aggttctgaa aaatgtacca gattggtgtt cattttataa attaacattc     9960

attaaaaact tatgtagaca ggtagaaata cctgctggca gtattaagaa gatcttaaat    10020

gttcttaggt atagattgtg cagcaaggga ggtgtagaac aacatagtga agaagatctg    10080

agaagactgt tgacagataa tttagacagt tgggatggaa acgacacagt taagttctta    10140

gttacaactt atataagcaa aggactcatg gcgttaaaca gttacaatca tatgggtcag    10200

ggtattcacc atgcaacatc ttcggtgtta acttccctag ctgctgtgct ctttgaggag    10260

ctggcaattt tttatcttaa gagaagctta ccccagacaa cagtacatgt tgaacatgcc    10320

ggtagttcag atgattacgc aaagtgtata gtggtgactg gtatactatc caaagagctc    10380

tactcccagt atgatgaaac attttggaaa cacgcttgca gactcaaaaa cttcacggcc    10440

gcggtacaaa gatgctgtca aatgaaagat agtgccaaaa ccttggtgag cgactgcttt    10500

ctcgagtttt acagtgagtt tatgatgggc tacagagtaa cccctgctgt aataaagttc    10560

atgtttactg gactgataaa cagctctgtg acctctcctc agagtttgat gcaagcatgc    10620

caagtttcat cccaacaagc aatgtataat agtgttcctc ttgtcaccaa cactgccttc    10680

accctattaa ggcagcaaat tttctttaac catgttgaag actttatcag aaggtatggt    10740

atactgactc ttgggacttt gtcacccttt ggtaggttgt tcgtaccaac ctactctgga    10800

ttagtcagct cagcggttgc tttagaagat gctgaagtca ttgctagagc agcccaaaca    10860

cttcaaatga acagtgtgtc aatacagtca agtagcttga ccacattaga tagcctaggt    10920

cgtagtagga caagttccac agctgaggat agcagcagtg tgagcgacac aactgctgct    10980

tcccatgact caggatcatc atcctcaagc ttctcttttg agctcaatag acccctgtct    11040

gaaactgaac tacagttcat taaagcacta agtagtctca agtcaacaca agcctgtgaa    11100

gtgattcaaa atagaattac aggtctttat tgcaacagca acgaaggacc tcttgatagg    11160

cataatgtca tttacagcag cagaatggca gactcttgcg attggctaaa ggatggtaaa    11220

aggagaggga atctagaact agcgaatagg atccaatctg tactgtgtat tctgatagca    11280

ggatattaca ggtcatttgg aggggaagga accgagaaac aggtaaaggc atcattgaat    11340

agagacgaca ataaaatcat agaggatcct atgatacaac taattccaga aaagctgagg    11400

agagagttag aaaggttagg tgtttctaga atggaagtcg atgagctaat gccaagcatt    11460

agtcctgatg acaccttagc ccagcttgta gcgaaaaaac tcattagcct caatgtttcg    11520

acagaagaat actcagctga ggtatctaga ctcaaacaaa cactgacagc ccgaaatgtt    11580

ttgcacgggt tagctggagg gattaaggag ctttcgcttc caatatatac aatattcatg    11640

aaatcttact tctttaaaga caatgttttc ctgtcactaa cagatagatg gtctaccaag    11700

cacagtacaa actatcgtga tagttgtggc aaacaattaa aaggtagaat aattaccaag    11760

tatactcact ggttggacac ttttctgggc tgctctgtct ccatcaacag gcatactact    11820

gttaaagagc cctccttatt caatccgaac atcagatgtg tgaatctgat cacatttgag    11880

gacggcctga gagaactatc agtgatacag agtcacctta aagtctttga aaatgagttc    11940

accaacttaa atcttcaatt ctctgatccg aacagacaga aacttagaat agttgagtct    12000

agacctgcag aatctgagct agaggcaaac cgtgcagtaa ttgtcaagac caaattgttt    12060

tcagcaactg aacaagttcg actatccaac aaccctgcag ttgtcatggg ctacctattg    12120

gatgaatcag caatttcaga agtcaagcct accaaggttg acttctcaaa tttacttaaa    12180

gaccgcttca aaataatgca attttttcct tcagtgttca ctttgattaa gatgctgaca    12240

gatgaatcgt cagattcaga aaagagtggc cttagtccag atttgcaaca agttgcaaga    12300

tactcaaacc atttgacctt gctcagcaga atgattcaac aagcaaagcc aaccgtgact    12360

gttttctaca tgctaaaagg taacttgatg aacacagagc caacagttgc tgagcttgtc    12420

agctatggta taaaggaagg cagatttttt aggctttccg acaccggagt cgatgcaagc    12480

acatactctg taaaatattg gaaaattctt cactgcatct ctgccattgg atgtttacct    12540

ttgagtcaag cagacaaatc ttcactactt atgagcttct taaactggag ggtcaacatg    12600

gacattagaa catctgactg tccactatct agtcatgaag caagtatact gagtgaattt    12660

gatggacaag ttatcgccaa catacttgcc agtgaattga gttctgtgaa acgagattct    12720

gaacgcgagg gtctaactga tctccttgat tatctaaact caccaactga attgttgaag    12780

aagaagcctt acttagggac aacttgcaag ttcaacacct ggggagactc gaatagatct    12840

ggaaagttca catacagcag cagatctgga gaatccattg gaatcttcat tgcagggaaa    12900

ttgcacatcc atctctcatc tgagtccgtt gccttgttgt gtgaaactga aagacaagtg    12960

ctttcttgga tgagtaagag gaggactgag gtaataacta aagaacagca tcaactgttt    13020

ctaagtcttc tcccacagtc tcatgagtgt ttacaaaagc acaaggacgg tagtgcgcta    13080

tcagtcatac ctgatagcag caacccccga ttacttaagt ttgtgcccct caaaaaaggt    13140

ctagcagtgg tgaaaatcaa aaaacaaatt ttaacagtga agaagcaggt tgtgtttgat    13200

gcagagagcg agcctagact gcagtggggg catggctgct tgtccattgt ttatgacgaa    13260

actgatactc agaccacata ccatgaaaat cttttgaagg tgaagcatct tgtagactgc    13320

tctacagata gaaaaaagct tttgccccag tcagtgtttt ctgactccaa agttgtcctt    13380

tcaaggatca agttcaagac ggagcttctc ctcaactcat tgacgctgct ccactgtttc    13440

ctaaaacatg ctcctagtga tgccataatg gaggtagaga gcaaaagtag cttgctacac    13500

aagtacctca aatcgggagg tgtcaggcaa cggaacactg aagtgctctt cagagagaag    13560

ttaaacaagg ttgttataaa agacaatctt gagcaaggtg tggaagagga gattgagttt    13620

tgcaacaact tgactaagac tgtttcagag aacccattac cactcagctg ttggtctgaa    13680

gttcaaaatt acattgaaga cataggcttt aacaatgtac ttgttaacat tgacagaaac    13740

acggtgaaaa gtgaactttt atggaaattt acgttagaca ccaatgtaag caccacaagt    13800

actataaaag acgtgaggac attggtgtcc tacgttagca ctgaaaccat ccctaagttc    13860

ttgcttgcat tcttacttta tgaagaagtg ttaatgaact taatcaacca gtgtaaggca    13920

gtaaaagaac tcatcaacag cacaggactc tcagacttgg aactggaaag cttactcact    13980

ttatgtgctt tctatttcca aagtgagtgc agtaagagag atggtcctag atgctccttt    14040

gcagcactat taagtctaat ccatgaggat tggcagagga taggtaaaaa cattcttgtt    14100

cgtgcaaaca atgaactagg tgatgtgtca ctgaaggtta acattgtcct ggtgcctctc    14160

aaggacatgt ctaagccaaa gtctgagaga gtggtcatgg ctagaaggtc actaaatcat    14220

gctctatcct tgatgtttct ggacgagatg tcactacctg agctaaaatc cttatccgtg    14280

aactgcaaaa tggggaactt tgaagggcag gagtgctttg agttcactat tctgaaggac    14340

aatagcgcaa gactagatta caacaagttg attgaccact gtgtggacat ggaaaaaaag    14400

agggaagcgg ttagagcagt agaagattta attttgatgt tgacaggcag agcagtcaaa    14460

cccagcgctg taacacagtt tgtacacggg gacgagcagt gtcaagagca aataagctta    14520

gatgatctga tggcaaacga cacggtaaca gactttcctg atagggaagc agaagccctc    14580

aaaacaggaa atcttggctt taactgggac tcagattgaa catgccgctt ataagccatt    14640

aatacctttc ggcgtcacaa ggacaaatga tgcagtttta gctgcatcat tcattaacat    14700

taaagccttc aaacaagcta actactctgc attctcctca atcaactcaa ttgcttcaac    14760

tgatctattt tactagctca tcgatcctct ctttcttagc tattcatttc agcttcatca    14820

tcatcgttat tatcttgggg tgtgggggga acgatttctt tgagagggtc ggcatggcat    14880

ctccacctcc tcgcggtccg acctgggcat ccgaaggagg acgtcgtcca ctcggatggc    14940

taagggagag ctcggatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg    15000

ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt    15060

tttt                                                                 15064


<210>  3
<211>  6225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pC-N)

<400>  3
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc gcaccccctc     1440

tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg ccgcaggggg     1560

acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg     1620

gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca     1680

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attcgagctc atcgatgcat     1740

ggttctcttg atggaaaaca agatcgaggt gaataacaaa gatgagatga acaggtggtt     1800

tgaagagttc aaaaaaggaa atggacttgt ggacaccttc acaaactcct attccttttg     1860

cgagagtgtt cccaatttgg acaggtttgt gtttcagatg gccagtgcca ccgatgatgc     1920

acagaaggac tccatctacg catctgctct ggtggaggca acaaagtttt gtgcacctat     1980

atatgagtgc gcatgggtta gctccactgg cattgtaaaa aagggacttg aatggttcga     2040

gaaaaatgca ggaaccatta agtcctggga tgaaagttat actgagctaa aggtcgacgt     2100

cccgaaaata gagcagctta ccggttacca acaagctgcc ttgaagtgga gaaaagacat     2160

aggtttccgt gtcaatgcca acacagcagc tctgagcaac aaagtcctcg cagaatacaa     2220

agtccctggt gagattgtga tgtctgtcaa agagatgctg tcagacatga ttaggagaag     2280

gaacctgatt ctaaacaggg gtggtgatga gaacccacgt ggcccagtga gccatgagca     2340

tgtagactgg tgcagggagt ttgtcaaagg caaatacatc atggccttca acccaccatg     2400

gggggacatc aacaagtcag gccgttcagg aatagcactt gttgcaacag gccttgctaa     2460

gcttgcagag actgaaggaa agggaatatt tgatgaagcc aaaaagactg tggaggccct     2520

caacgggtat ctggacaagc ataaggacga agttgataga gcaagcgccg acagcatgat     2580

aacaaacctt cttaagcata ttgccaaggc acaggagctc tataaaaatt catctgcact     2640

tcgtgcacaa agcgcacaga ttgacactgc tttcagctca tactattggc tttacaaggc     2700

tggcgtgact cctgaaacct tcccgacggt gtcacagttc ctctttgagc tagggaaaca     2760

gccaagaggt accaagaaaa tgaagaaggc tcttctgagc accccaatga agtgggggaa     2820

gaagctttat gagctctttg ccgatgattc tttccagcag aacaggattt acatgcatcc     2880

tgccgtgctt acagctggta gaatcagtga aatgggagtc tgctttggga caatccctgt     2940

ggccaatcct gatgatgctg cccaaggatc tggacacact aagtctattc tcaacctccg     3000

taccaacact gagaccaata atccgtgtgc caaaaccatc gtcaagctat ttgaagttca     3060

aaaaacaggg ttcaacattc aggacatgga catagtggcc tctgagcact tgctacacca     3120

atcccttgtt ggcaagcaat ccccattcca gaacgcctac aacgtcaagg gcaatgccac     3180

cagtgctaac atcatttaaa atacaaactg ctctgtactc aacttccggg catgctcgag     3240

ctagcagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat     3300

ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg     3360

tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat     3420

ttggtttaga gtttggcaac atatgccata tgctggctgc catgaacaaa ggtggctata     3480

aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc atagaaaagc     3540

cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt ctttaacatc     3600

cctaaaattt tccttacatg ttttactagc cagatttttc ctcctctcct gactactccc     3660

agtcatagct gtccctcttc tcttatgaag atccctcgac ctgcagccca agcttggcgt     3720

aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca     3780

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat     3840

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagcggatcc     3900

gcatctcaat tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac     3960

tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga     4020

ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg     4080

cctaggcttt tgcaaaaagc taacttgttt attgcagctt ataatggtta caaataaagc     4140

aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg     4200

tccaaactca tcaatgtatc ttatcatgtc tggatccgct gcattaatga atcggccaac     4260

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     4320

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     4380

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     4440

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     4500

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     4560

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     4620

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct     4680

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     4740

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     4800

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     4860

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     4920

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     4980

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     5040

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     5100

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     5160

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     5220

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     5280

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     5340

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     5400

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     5460

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     5520

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     5580

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     5640

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     5700

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     5760

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     5820

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     5880

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     5940

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     6000

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     6060

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa     6120

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     6180

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctg                     6225


<210>  4
<211>  16635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pC-L)

<400>  4
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc gcaccccctc     1440

tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg ccgcaggggg     1560

acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg     1620

gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca     1680

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attcgagctc atcgatgcat     1740

gaccggtaac catgggtaag cctatcccta accctctcct cggtctcgat tctacgatgg     1800

acttcttgag aagccttgac tggactcaag tgattgctgg tcaatatgtg tccaacccta     1860

ggttcaacat ttctgattat tttgagattg tgcggcagcc tggtgatggg aactgcttct     1920

atcacagcat agctgagtta accatgccta acaaaacaga tcactcatat cattacatca     1980

aacgcctaac cgagtcggca gcacggaagt attaccaaga ggagcctgaa gccagacttg     2040

ttggcctgag cctggaagat tacctcaaga ggatgctgtc tgacaacgag tggggatcaa     2100

ctctagaagc atctatgttg gctaaagaaa tgggcattac catcatcatt tggactgttg     2160

ctgccagtga tgaagtggaa gcaggtataa agttcggaga cggtgatgtg tttacagctg     2220

tgaacctttt gcactctgga caaacacact ttgatgcgct cagaatactt ccgcagtttg     2280

aaacagacac aagagaggcc ttgagcttga tggacagggt tatagctgtg gatcagttga     2340

catcatcttc tagtgatgaa ctgcaagact atgaagacct tgccttggca ctcacaagcg     2400

cagaagaatc aaatagacgg tcaagcttgg atgaggtcac attgtccaag aagcaagcag     2460

agatactaag gcaaaaagca tctcagttgt ctaaattggt taataaaagt cagaacatac     2520

cgaccagagt cggtagagtc ttggattgca tgttcaactg caaattatgt gttgagatat     2580

cagctgacac tttaattctg aggccagaat caaaagagaa aatcggtgaa atcatgtcat     2640

tgcggcagtt ggggcataaa ctgctgacac gagacaaaca gattaagcaa gagttctcca     2700

gaatgaaact ctacgtcact aaagatttgc ttgaccatct agacgttggt gggctcttga     2760

gggctgcttt ccctggaaca ggaatagaaa ggcatatgca gctgctacac tctgagatga     2820

tactggacat ctgcactgta tcacttggtg tcatgctgtc aacattctta tatggttcta     2880

ataataaaaa caagaagaaa ttcattacca actgtctgct cagcacagcc ctatccggaa     2940

agaaggtgta taaagttctc ggcaacctag gaaatgaact gttgtacaag gcacctagaa     3000

aggccttagc aactgtctgc agtgccttgt ttgggaagca gataaacaaa cttcagaatt     3060

gcttcaggac cataagccct gtcagcttac ttgcattgag aaatctagac tttgattgtc     3120

tcagtgtgca agactataat ggtatgatag aaaacatgtc taaattagac aacactgatg     3180

ttgaattcaa ccacagggag atagctgatc tcaaccaatt aacttctcgg ctcatcacat     3240

taagaaagga gaaagacact gacctcctca aacaatggtt tcctgaaagt gacctcaccc     3300

gcagaagcat caggaatgct gcaaacgcgg aggaatttgt catatctgag ttctttaaga     3360

agaaggacat tatgaaattc atcagcactt caggcagagc aatgagtgca ggcaagattg     3420

gtaatgtcct atcctatgca cataatcttt atttgagtaa gtcaagccta aatatgacct     3480

ctgaagacat ctcacagctt ttgatcgaga ttaagcgact gtatgcttta caagaagatt     3540

ctgaagtgga gccgatagcc ataatttgtg atggcataga aagcaacatg aaacagttat     3600

ttgctatatt gcctcctgac tgtgcaagag agtgtgaagt cctcttcgat gacataagaa     3660

attctccaac acacagcaca gcctggaagc atgcactccg attaaaaggg actgcatacg     3720

aaggtctgtt tgcaaattgt tacggctggc aatacattcc ggaagacatt aaaccaagcc     3780

tgaccatgtt gatacagact ttgtttcctg acaagttcga agatttcctg gatcgaaccc     3840

agttgcatcc ggagttcaga gacctgactc ccgacttttc gctcacacaa aaggttcact     3900

ttaaaagaaa tcagataccc agtgtcgaaa atgtgcaaat ctccattgat gcgacgttgc     3960

ctgaatctgt ggaagcagta ccagtgacag aaagaaagat gttccccctt cctgagactc     4020

cgctaagtga ggtgcattca atagagcgta taatggaaaa ctttactcgc ctcatgcatg     4080

gaggaagact ttcgaccaag aaaagagatg gagatccggc ggaacagggc aaccagcaga     4140

gtatcactga acacgagagt tccagcatct ctgcctttaa agactacgga gagagaggga     4200

tagtcgagga aaatcacatg aagtttagtg gagaagatca gctagagaca aggcagctgt     4260

tgttggtgga agttggtttt caaactgaca tcgatgggaa aataaggaca gaccacaaga     4320

agtggaaaga catattaaag ctattagagc tactaggaat caagtgctca ttcattgcct     4380

gtgcagattg ctcatccaca ccaccagaca gatggtggat tacggaggac agagtgcgag     4440

tcctaaaaaa ttcagtcagc ttcttgttca ataaactctc cagaaactca cctacagaag     4500

taactgacat agttgttgga gctataagta ctcaaaaggt tagaagttat ctaaaggcag     4560

gaactgcaac aaaaacccct gtgtcgacta aagacgttct ggagacttgg gaaaagatga     4620

aggagcacat actcaacaga ccaacaggac tgacactgcc caccagtttg gaacaggcaa     4680

tgcgcaaagg actggtcgaa ggtgtggtca tctccaagga aggttctgag tcatgtatca     4740

atatgttgaa ggaaaatttg gaccgaataa ctgacgaatt cgagcgaaca aaatttaaac     4800

atgaacttac tcagaatatt accacaagtg agaagatgct attgagttgg ttgagtgaag     4860

acatcaaatc atcgagatgt ggtgagtgcc tctcaaatat aaagaaagcc gttgatgaaa     4920

ctgccaatct atcagaaaag attgagctgc tcgcttataa tctgcaactc accaatcact     4980

gcagcaactg tcaccccaat ggtgtaaaca ttagtaacac ttctaatgtg tgcaagagat     5040

gccccaagat tgaagtggtt agccattgtg aaaataaagg ctttgaggac agcaatgaat     5100

gcttaacaga cctagatagg cttgttaggc tcacattacc agggaaaact gagaaggaga     5160

gaagagtcaa acgtaatgtg gaatatctta taaaactgat gatgagcatg tcaggcattg     5220

attgtataaa atatcccaca gggcagctta tcacccatgg aagagtgagt gcaaaacata     5280

acgatgggaa cctgaaagat agaagcgatg acgaccaaag actagctgag aagatagaca     5340

ctgttaggaa agagctttca gaatctaaac tgaaagatta ttcaacttat gcaaggggag     5400

tgatatcaaa ttcactaaaa aacctctcaa ggcaaggtaa atcaaagtgt tctgtgccaa     5460

gatcttggct cgagaaagta ctgtttgacc tgaaggtgcc tactaaggac gaagaagtgc     5520

ttataaacat cagaaactca ttgaaagcta gatccgagtt tgttagaaat aacgataaac     5580

tactcataag gtcaaaagaa gaactaaaaa aatgtttcga tgtgcagtct tttaaattga     5640

aaaaaaacaa gcaacctgtg ccctttcagg ttgactgtat attgttcaaa gaagtggcag     5700

ctgaatgcat gaagaggtac attggcacac cttatgaggg aattgtagac accttagttt     5760

ctctgattaa tgtgttaaca aggtttactt ggttccagga agtggtgcta tatggtaaaa     5820

tatgtgagac cttcctaaga tgctgcacag aatttaatag gtcaggggtc aaactggtta     5880

agataaggca ctgtaacatt aacctatcag tcaaattgcc atcaaataag aaagagaata     5940

tgttatgttg tctatatagt ggaaacatgg agctcttgca aggacctttc tatttgaaca     6000

ggagacaagc tgtccttggt tcttcatacc tttacattgt cattacactt tacatacaag     6060

tgctgcagca gtacaggtgt ctagaagtta taaacagtgt gagtgaaaaa acattgcaag     6120

acattgaaaa tcattccatg actctactag aagattcatt cagggaaatc acttttgctc     6180

ttgaaggtag gtttgaagaa tcttataaaa tacgaacctc gaggtgcaga gccagtggga     6240

attttctgaa caggagcagt agagaccact ttataagcgt tgtttcaggc ttgaacctag     6300

tttatggctt cctcataaaa gataacttac tagccaactc tcagcaacag aacaaacaac     6360

tacagatgct tcgttttggc atgcttgcag ggcttagtag gcttgtttgt cctaatgagc     6420

taggaaagaa attttcaacg agctgtagaa gaattgaaga caacattgca aggctttacc     6480

tgcagacatc catttactgt tcagtcaggg atgtggagga caatgttaag cactggaaac     6540

aaagagatct atgtcctgaa gtaaccattc catgctttac agtctatgga acctttgtca     6600

acagcgatag acaactgatc tttgacattt acaatgtgca tatatataat aaagaaatgg     6660

acaactttga tgaaggatgt atcagcgtct tggaagaaac agcagaaagg cacatgcttt     6720

gggaactcga tctgatgaat tcactttgtt ctgacgaaaa aaaagatact agaaccgcaa     6780

gactattact aggctgccca aatgtgagga aagcagcaaa cagagaaggg aagaagctgt     6840

tgaagttaaa cagtgacaca tccacagaca cacagagcat tgcttctgaa gtgtcggaca     6900

gaaggtctta tagttcaagt aagagtagaa tccgtagtat atttggtaga tacaactctc     6960

agaagaaacc atttgaatta aggtcaggtc ttgaggtttt caatgatcct ttcaatgatt     7020

atcagcaagc aataacggac atttgccaat tttctgagta cacaccaaac aaagaaagca     7080

ttttgaaaga ctgtcttcaa atcatacgaa aaaaccctag ccacacaatg ggttcttttg     7140

agctgatcca ggcaatctca gagttcggca tgagcaagtt tcctcccgaa aatatagaca     7200

aagcaagaag ggatccgaag aactgggtta gcatctctga agtaaccgaa acaacaagta     7260

tagttgcatc acctagaact catatgatgc tcaaggattg ttttaaaatt atactaggta     7320

ctgagaataa gaagatagtc aaaatgcttc gaggtaagct aaagaaactc ggtgctatct     7380

caacaaacat agagatcggg aaaagggatt gcctagatct actcagcaca gtagatgggc     7440

taacagacca gcagaaagaa aatattgtaa atgggatatt tgagccctca aagttatcct     7500

tctaccattg gaaggaattg gtcaaaaaaa acattgatga agttttactt actgaagatg     7560

gaaatctgat cttctgctgg ctgaaaacaa tctcctcttc agtcaaagga agcctaaaga     7620

agagactcaa attcatgaat atacattctc cagaattgat gccggaaaac tgtctctttt     7680

ctagtgagga attcaatgag ttaattaagt tgaagaaact cctcctcaat gaacaacaag     7740

atgaacagga gctgaaacaa gatcttttga tatcttcttg gatcaagtgc ataacagctt     7800

gcaaggattt tgcaagcatc aatgacaaga ttcagaagtt catttaccac ctgtctgaag     7860

agctatatga cataaggctg cagcatctgg aactgtcaaa gcttaagcaa gagcacccta     7920

gtgtcagctt cacaaaagaa gaagtcttaa taaagcggct ggagaaaaat ttccttaagc     7980

agcataattt agagattatg gaaactgtga atcttgtatt ctttgcagcc ctctcagctc     8040

cctggtgctt acactataaa gcactagagt cttatttggt gagacatcca gaaatacttg     8100

actgtggatc taaggaggac tgcaaactca ccttgcttga tctgtcagtt tctaagctct     8160

tggtttgttt gtatcaaaaa gatgatgagg agctgataaa tagctcaagt ttgaaacttg     8220

ggtttttagt gaaatatgtt gtcaccttgt tcacatccaa tggtgaacct ttttcactca     8280

gtctcaatga cgggggtttg gatcttgatt tacacaagac tactgacgaa aagttactac     8340

atcaaacaaa gatagttttt gctaaaattg gtttatctgg gaacagttat gactttatct     8400

ggactaccca aatgatagca aacagcaatt ttaacgtctg caaaagatta acgggaagga     8460

gtactgggga aaggctccct agaagcgtta gaagcaaggt catatatgag atggtaaaat     8520

tagtgggaga aacaggcatg gcaatactac aacaattagc ttttgcacaa gcactaaatt     8580

atgagcaccg cttctatgcg gtcttagcac ctaaagcgca actaggagga gcaagagatt     8640

tgttagtgca agagactggg actaaagtca tgcatgcaac cactgaaatg tttagtagaa     8700

atcttttaaa aacaacatca gatgatggcc tcacaaaccc acatcttaaa gaaacaatcc     8760

ttaatgtggg attagactgt cttgctaaca tgcgaaatct tgacggtaag cccataagtg     8820

aaggtagtaa cttggtcaat ttctacaaag tcatatgtat ctcgggtgat aataccaagt     8880

ggggcccgat acactgctgt tctttctttt ctggcatgat gcaacaggtt ctgaaaaatg     8940

taccagattg gtgttcattt tataaattaa cattcattaa aaacttatgt agacaggtag     9000

aaatacctgc tggcagtatt aagaagatct taaatgttct taggtataga ttgtgcagca     9060

agggaggtgt agaacaacat agtgaagaag atctgagaag actgttgaca gataatttag     9120

acagttggga tggaaacgac acagttaagt tcttagttac aacttatata agcaaaggac     9180

tcatggcgtt aaacagttac aatcatatgg gtcagggtat tcaccatgca acatcttcgg     9240

tgttaacttc cctagctgct gtgctctttg aggagctggc aattttttat cttaagagaa     9300

gcttacccca gacaacagta catgttgaac atgccggtag ttcagatgat tacgcaaagt     9360

gtatagtggt gactggtata ctatccaaag agctctactc ccagtatgat gaaacatttt     9420

ggaaacacgc ttgcagactc aaaaacttca cggccgcggt acaaagatgc tgtcaaatga     9480

aagatagtgc caaaaccttg gtgagcgact gctttctcga gttttacagt gagtttatga     9540

tgggctacag agtaacccct gctgtaataa agttcatgtt tactggactg ataaacagct     9600

ctgtgacctc tcctcagagt ttgatgcaag catgccaagt ttcatcccaa caagcaatgt     9660

ataatagtgt tcctcttgtc accaacactg ccttcaccct attaaggcag caaattttct     9720

ttaaccatgt tgaagacttt atcagaaggt atggtatact gactcttggg actttgtcac     9780

cctttggtag gttgttcgta ccaacctact ctggattagt cagctcagcg gttgctttag     9840

aagatgctga agtcattgct agagcagccc aaacacttca aatgaacagt gtgtcaatac     9900

agtcaagtag cttgaccaca ttagatagcc taggtcgtag taggacaagt tccacagctg     9960

aggatagcag cagtgtgagc gacacaactg ctgcttccca tgactcagga tcatcatcct    10020

caagcttctc ttttgagctc aatagacccc tgtctgaaac tgaactacag ttcattaaag    10080

cactaagtag tctcaagtca acacaagcct gtgaagtgat tcaaaataga attacaggtc    10140

tttattgcaa cagcaacgaa ggacctcttg ataggcataa tgtcatttac agcagcagaa    10200

tggcagactc ttgcgattgg ctaaaggatg gtaaaaggag agggaatcta gaactagcga    10260

ataggatcca atctgtactg tgtattctga tagcaggata ttacaggtca tttggagggg    10320

aaggaaccga gaaacaggta aaggcatcat tgaatagaga cgacaataaa atcatagagg    10380

atcctatgat acaactaatt ccagaaaagc tgaggagaga gttagaaagg ttaggtgttt    10440

ctagaatgga agtcgatgag ctaatgccaa gcattagtcc tgatgacacc ttagcccagc    10500

ttgtagcgaa aaaactcatt agcctcaatg tttcgacaga agaatactca gctgaggtat    10560

ctagactcaa acaaacactg acagcccgaa atgttttgca cgggttagct ggagggatta    10620

aggagctttc gcttccaata tatacaatat tcatgaaatc ttacttcttt aaagacaatg    10680

ttttcctgtc actaacagat agatggtcta ccaagcacag tacaaactat cgtgatagtt    10740

gtggcaaaca attaaaaggt agaataatta ccaagtatac tcactggttg gacacttttc    10800

tgggctgctc tgtctccatc aacaggcata ctactgttaa agagccctcc ttattcaatc    10860

cgaacatcag atgtgtgaat ctgatcacat ttgaggacgg cctgagagaa ctatcagtga    10920

tacagagtca ccttaaagtc tttgaaaatg agttcaccaa cttaaatctt caattctctg    10980

atccgaacag acagaaactt agaatagttg agtctagacc tgcagaatct gagctagagg    11040

caaaccgtgc agtaattgtc aagaccaaat tgttttcagc aactgaacaa gttcgactat    11100

ccaacaaccc tgcagttgtc atgggctacc tattggatga atcagcaatt tcagaagtca    11160

agcctaccaa ggttgacttc tcaaatttac ttaaagaccg cttcaaaata atgcaatttt    11220

ttccttcagt gttcactttg attaagatgc tgacagatga atcgtcagat tcagaaaaga    11280

gtggccttag tccagatttg caacaagttg caagatactc aaaccatttg accttgctca    11340

gcagaatgat tcaacaagca aagccaaccg tgactgtttt ctacatgcta aaaggtaact    11400

tgatgaacac agagccaaca gttgctgagc ttgtcagcta tggtataaag gaaggcagat    11460

tttttaggct ttccgacacc ggagtcgatg caagcacata ctctgtaaaa tattggaaaa    11520

ttcttcactg catctctgcc attggatgtt tacctttgag tcaagcagac aaatcttcac    11580

tacttatgag cttcttaaac tggagggtca acatggacat tagaacatct gactgtccac    11640

tatctagtca tgaagcaagt atactgagtg aatttgatgg acaagttatc gccaacatac    11700

ttgccagtga attgagttct gtgaaacgag attctgaacg cgagggtcta actgatctcc    11760

ttgattatct aaactcacca actgaattgt tgaagaagaa gccttactta gggacaactt    11820

gcaagttcaa cacctgggga gactcgaata gatctggaaa gttcacatac agcagcagat    11880

ctggagaatc cattggaatc ttcattgcag ggaaattgca catccatctc tcatctgagt    11940

ccgttgcctt gttgtgtgaa actgaaagac aagtgctttc ttggatgagt aagaggagga    12000

ctgaggtaat aactaaagaa cagcatcaac tgtttctaag tcttctccca cagtctcatg    12060

agtgtttaca aaagcacaag gacggtagtg cgctatcagt catacctgat agcagcaacc    12120

cccgattact taagtttgtg cccctcaaaa aaggtctagc agtggtgaaa atcaaaaaac    12180

aaattttaac agtgaagaag caggttgtgt ttgatgcaga gagcgagcct agactgcagt    12240

gggggcatgg ctgcttgtcc attgtttatg acgaaactga tactcagacc acataccatg    12300

aaaatctttt gaaggtgaag catcttgtag actgctctac agatagaaaa aagcttttgc    12360

cccagtcagt gttttctgac tccaaagttg tcctttcaag gatcaagttc aagacggagc    12420

ttctcctcaa ctcattgacg ctgctccact gtttcctaaa acatgctcct agtgatgcca    12480

taatggaggt agagagcaaa agtagcttgc tacacaagta cctcaaatcg ggaggtgtca    12540

ggcaacggaa cactgaagtg ctcttcagag agaagttaaa caaggttgtt ataaaagaca    12600

atcttgagca aggtgtggaa gaggagattg agttttgcaa caacttgact aagactgttt    12660

cagagaaccc attaccactc agctgttggt ctgaagttca aaattacatt gaagacatag    12720

gctttaacaa tgtacttgtt aacattgaca gaaacacggt gaaaagtgaa cttttatgga    12780

aatttacgtt agacaccaat gtaagcacca caagtactat aaaagacgtg aggacattgg    12840

tgtcctacgt tagcactgaa accatcccta agttcttgct tgcattctta ctttatgaag    12900

aagtgttaat gaacttaatc aaccagtgta aggcagtaaa agaactcatc aacagcacag    12960

gactctcaga cttggaactg gaaagcttac tcactttatg tgctttctat ttccaaagtg    13020

agtgcagtaa gagagatggt cctagatgct cctttgcagc actattaagt ctaatccatg    13080

aggattggca gaggataggt aaaaacattc ttgttcgtgc aaacaatgaa ctaggtgatg    13140

tgtcactgaa ggttaacatt gtcctggtgc ctctcaagga catgtctaag ccaaagtctg    13200

agagagtggt catggctaga aggtcactaa atcatgctct atccttgatg tttctggacg    13260

agatgtcact acctgagcta aaatccttat ccgtgaactg caaaatgggg aactttgaag    13320

ggcaggagtg ctttgagttc actattctga aggacaatag cgcaagacta gattacaaca    13380

agttgattga ccactgtgtg gacatggaaa aaaagaggga agcggttaga gcagtagaag    13440

atttaatttt gatgttgaca ggcagagcag tcaaacccag cgctgtaaca cagtttgtac    13500

acggggacga gcagtgtcaa gagcaaataa gcttagatga tctgatggca aacgacacgg    13560

taacagactt tcctgatagg gaagcagaag ccctcaaaac aggaaatctt ggctttaact    13620

gggactcaga ttgacccggg catgctcgag ctagcagatc tttttccctc tgccaaaaat    13680

tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt    13740

ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg    13800

gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgccata    13860

tgctggctgc catgaacaaa ggtggctata aagaggtcat cagtatatga aacagccccc    13920

tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt    13980

ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc    14040

cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc tcttatgaag    14100

atccctcgac ctgcagccca agcttggcgt aatcatggtc atagctgttt cctgtgtgaa    14160

attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct    14220

ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc    14280

agtcgggaaa cctgtcgtgc cagcggatcc gcatctcaat tagtcagcaa ccatagtccc    14340

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca    14400

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt    14460

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc taacttgttt    14520

attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca    14580

tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc    14640

tggatccgct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc    14700

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg    14760

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa    14820

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg    14880

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga    14940

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg    15000

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg    15060

gaagcgtggc gctttctcaa tgctcacgct gtaggtatct cagttcggtg taggtcgttc    15120

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg    15180

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca    15240

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt    15300

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag    15360

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg    15420

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc    15480

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt    15540

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt    15600

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca    15660

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg    15720

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac    15780

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg    15840

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc    15900

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta    15960

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac    16020

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc    16080

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac    16140

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact    16200

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa    16260

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt    16320

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca    16380

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa    16440

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac    16500

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg    16560

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc    16620

gaaaagtgcc acctg                                                     16635


<210>  5
<211>  9772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pC-GPC-Oman)

<400>  5
cgcaccatgc ccgtcaatac tatgcacacc ctgctggtct atgctgtctt ctgtctgcag       60

ctgtggagcc ctgggggaac acgaggcctg agcaatgaga cccagcacaa cgaaacagga      120

atcacccggg cccccgaggg gtcccaggga ccttctctgc cagtgtccac agcatctcca      180

atcatgagtg acccctcaat taccacactg tcagccagca cttccggcct ggaagggagc      240

ggagatacta ccccccctgc cattacacag gggcccactc tgcctgagac aactcccgaa      300

ccttccacca caactggaac caatgctttt agtacagcta tcgcaaacgt ctcaacacag      360

actgtgaagg acaccccaac acccactgtg cagactagcc caccctccac cccagatgcc      420

tctacaattc cccagggcac ccaccataca gctagggggc tgctgagtgt gaccgtcaca      480

aaaccagagg aagtgcctac tccaaccggc cccgagcagg cttccatcga aaccaatagc      540

tccagactgg caacttctaa gaccccctct cctagtccaa cagcccaggt gaccacagag      600

aactcaaatc caaacactag caggcagctg gtcctgagca cccagccagc tacatctagt      660

cctgtgacca gcccagcaca gctgaacttc gtccagtccg ctactaccat cgcagtgcag      720

gacgcacacc catcccctac taatcgatct aagcggaacc tggagatgga agtgattctg      780

accctgtccc aggggctgcg caaatactat ggacgaatcc tgaagctgct ggacctgact      840

ctggaggaag ataccgaggg cctgctggaa tggtgtaaac gaaatctggg gctgacctgc      900

gacgataact tctttcagaa gcggatcgag gagttcttcc tgacaggcga ggggcacttt      960

aacgaagtgc tgcagttcaa gacaccttct actctgagtc caactgaatc agctagcgtc     1020

ggactgccaa ccgtggagcc tttcaaatca tactttgcaa agggattcct gtcaattgac     1080

agcggctact ttagtgcaaa gtgttatccc agagcctcca attctgggct gcagctgatc     1140

aacgtgacac agcatagcgc aaggatcgcc gatactccag gacccaaaat tactaatctg     1200

aagaccatca attgcattaa cctgaaagct ctggtgttca aggagcacag agagatcgaa     1260

attaacgtgc tgctgcctca ggtggcagtc aatctgtcca actgtcacgt ccatattaag     1320

agccatgtgt gcgattactc cctggacatc gatggcaccg tgagactgcc tagaatccac     1380

catgagggca cattcattcc agggacttac aagatcgtga tcgacaagaa aaataagcag     1440

aacgatcgct gtaatctggt caccaactgc gtgatcaaag gacgagaggt ccgaaaggga     1500

cagagcgtgc tgcggcagta tagaacagaa atccggattg gaaaggcttc aagcggcagt     1560

cggagactgc tgtccgagga atctggagag gactgcattt cacggaccca gctgctgaga     1620

acagagactg ccgaaatcca cggggacaat tacggcgggc caggagataa aatcactatt     1680

tgtaacggct ctaccattgt ggatcagagg ctgggcagtg agctggggtg ctataccatc     1740

aatcgcgtga agagcttcaa gctgtgtgaa aacagtgcca ccggcaagtc atgcgagatt     1800

gacaacacac ctgtgaagtg taaacagggg ttctgcctga aaatcaccca ggagggacgc     1860

ggccacgtga agctgagtcg agattcagag gtggtcctgg acgcctgtga ttcctcttgc     1920

gaaatcatga ttccaaaagg gacaggagac atcctggtgg attgctccgg aggccagcag     1980

cacttcctga aggacaatct gatcgatctg ggatgtccaa acattcccct gctgggcaaa     2040

atggccatct acatttgccg catgagcaac catcctaaga caactatggc tttcctgttt     2100

tggttctcct ttggctacgt catcacttgc attctgtgta aagtgatctt ctacctgctg     2160

attgtggtcg gcaccctggg gaagaaattc aaacagtatc gggaactgaa gccccagacc     2220

tgcacaatct gtgagaccac acctgtgaat gctattgacg cagaaatgca cgatctgaat     2280

tgttcctaca acatctgccc atattgtgcc agtcggctga cctcagacgg cctggctaga     2340

catgtgatgc agtgccccaa gaggaaagag aagattgagg aaacagaact gtacctgaac     2400

ctggagcgaa tcccttgggt ggtccggaaa ctgctgcagg tcagtgagtc aaccggggtg     2460

gcactgaaga gaagttcatg gctgatcgtc ctgctggtgc tgctgacagt cagcctgtcc     2520

ccagtgcagt ccgcacctat cggccacggg aaaaccattg aaacatacca gactagggag     2580

ggatatacct ctatctgtct gtttgtcctg ggctctatcc tgttcattgt gagtcatctg     2640

atgaagggac tggtggacag cgtgggcaat tccttctttc ctgggctgtc catttgcaaa     2700

acctgtagca tcggcagcat caacggcttt gagatcgaat cacacaagtg ctactgtagc     2760

ctgttctgct gtccatattg cagacattgt tctgccgata aagagatcca caagctgcat     2820

ctgtcaattt gcaagaaaag gaaagccggg agcaatgtca tgctggctgt gtgtaagcga     2880

atgtgctttc gggcaacaat ggaggtgagc aataaggccc tgctgatccg ctcagtgatt     2940

aacactacct tcgtggtctg tatcctgatt ctggctgtct gcgtggtctc taccagtgca     3000

gtggagatgg aaagcctgcc agcaggcaca tgggagagag aggaagacct gactaacttt     3060

tgtcaccagg aatgccaagt gactgagacc gaatgcctgt gtccttacga ggcactggtg     3120

ctgaggaagc cactgttcct ggattccatc gccaaaggca tgaagaatct gctgaactca     3180

acaagcctgg aaacttccct gtctatcgag gctccttggg gggcaattaa tgtccagagc     3240

acctttaagc caaccgtgtc cacagccaac atcgctctgt cttggagcag cgtcgagcac     3300

cgcggcaaca agatcctggt gagcggccgg agcgaatcaa ttatgaagct ggaggaaagg     3360

actggaatca gctgggacct gggcgtggag gatgctagcg aatccaagct gctgaccgtg     3420

tccgtcatgg acctgtctca gatgtacagt cccgtcttcg agtatctgtc tggagaccgc     3480

caggtggagg aatggcccaa agccacatgt actggagatt gccctgagcg gtgcggctgt     3540

acttctagta cctgtctgca caaggaatgg ccacatagca ggaattggcg ctgtaaccca     3600

acctggtgct ggggagtggg cacagggtgc acttgctgtg gcctggacgt gaaggacctg     3660

ttcaccgact acatgttcgt caaatggaag gtggagtata tcaagactga agcaattgtg     3720

tgtgtcgagc tgacctccca ggaacggcag tgctctctga tcgaggccgg gaccagattc     3780

aacctgggac ctgtgaccat cacactgagc gagccacgca atattcagca gaagctgcct     3840

ccagaaatcg tgacactgca cccccgaatt gaggaaggct tctttgatct gatgcatgtc     3900

cagaaagtgc tgtctgccag taccgtgtgt aagctgcagt cctgcacaca cggagtccct     3960

ggcgacctgc aggtgtacca tattgggaat ctgctgaaag gagataaggt caacggccac     4020

ctgatccata aggtggagcc acactttaac acctcttgga tgagttggga cggctgtgac     4080

ctggattact attgcaatat gggggattgg ccctcttgca cttacaccgg agtcacacag     4140

cacaaccatg ccgctttcgt gaatctgctg aacatcgaga ccgactacac aaagaacttc     4200

cactttcata gcaagagagt gaccgctcac ggggacacac cccagctgga tctgaaagct     4260

aggcctaact acggagcagg cgagatcacc gtgctggtcg aggtggccga tatggaactg     4320

catacaaaga aaatcgaaat tagtggactg aagttcgcat cactgacatg cactgggtgt     4380

tatgcctgct caagcggaat ctcttgcaaa gtccgcattc acgtggacga gcccgatgaa     4440

ctgaccgtcc atgtgaagag cgaggaccct gatatcgtgg cagcctcctc tagtctgatg     4500

gcccggaagc tggaatttgg cactgacagc accttcaaag cattttccgc catgccaaag     4560

acatctctgt gtttctacat cgtggagcgc gaatattgta aatcatgcag caaggaggac     4620

actcagaaat gcgtgaatgc caagctggaa cggccccaga gcatcctgat tgagcacaaa     4680

gggaccatca ttggaaagca gaacgatacc tgtacagcca aggctagctg ctggctggag     4740

tcagtgaaga gcttcttcta cggactgaag aatatgctgt ccgggatttt tggaaacgtg     4800

ttcatcggca ttttcctgtt tctggccccc tttatcctgc tgattctgtt ctttatgttc     4860

ggctggagaa tcctgttctg ctttaaatgc tgtaggcgca caagagggct gtttaaatac     4920

aggcacctga aggacgatga ggaaactgga tataggaaga tcattgagcg cctgaacaat     4980

aagaaaggca aaaacaagct gctggacggg gaaagactgg ccgataggaa aattgctgag     5040

ctgttctcca ctaagaccca tatcggctga tgatttttcc ctctgccaaa aattatgggg     5100

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     5160

caatagtgtg ttggaatttt ttgtgtctct cactcggaag gacatatggg agggcaaatc     5220

atttaaaaca tcagaatgag tatttggttt agagtttggc aacatatgcc atatgctggc     5280

tgccatgaac aaaggtggct ataaagaggt catcagtata tgaaacagcc ccctgctgtc     5340

cattccttat tccatagaaa agccttgact tgaggttaga ttttttttat attttgtttt     5400

gtgttatttt tttctttaac atccctaaaa ttttccttac atgttttact agccagattt     5460

ttcctcctct cctgactact cccagtcata gctgtccctc ttctcttatg aagatccctc     5520

gacctgcagc ccaagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta     5580

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc     5640

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg     5700

aaacctgtcg tgccagcgga tccgcatctc aattagtcag caaccatagt cccgccccta     5760

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga     5820

ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag     5880

tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctaacttg tttattgcag     5940

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     6000

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatcc     6060

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     6120

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     6180

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     6240

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     6300

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     6360

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     6420

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     6480

ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     6540

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     6600

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     6660

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     6720

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt     6780

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     6840

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     6900

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     6960

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     7020

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     7080

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     7140

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     7200

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     7260

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     7320

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat     7380

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     7440

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     7500

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     7560

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     7620

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     7680

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     7740

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     7800

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     7860

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     7920

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     7980

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     8040

gccacctggt cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt     8100

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     8160

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     8220

gccaataggg actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt     8280

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     8340

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     8400

catctacgta ttagtcatcg ctattaccat gggtcgaggt gagccccacg ttctgcttca     8460

ctctccccat ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat     8520

tttgtgcagc gatgggggcg gggggggggg ggccgcgcgc cagccggggc ggggcggggc     8580

gaggggcggg gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc     8640

cgaaagtttc cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg     8700

cggcgggcgg gagtcgctgc gttgccttcg ccccgtgccc cgctccgcgc cgcctcgcgc     8760

cgcccgcccc ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct     8820

tctcctccgg gctgtaatta gcgcttggtt taatgacggc tcgtttcttt tctgtggctg     8880

cgtgaaagcc ttaaagggct ccgggagggc cctttgtgcg ggggggagcg gctcgggggg     8940

tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc ccgcgctgcc cggcggctgt     9000

gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgcg tgtgcgcgag gggagcgcgg     9060

ccgggggcgg tgccccgcgg tgcggggggg ctgcgagggg aacaaaggct gcgtgcgggg     9120

tgtgtgcgtg ggggggtgag cagggggtgt gggcgcggcg gtcgggctgt aacccccccc     9180

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtgcgg     9240

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     9300

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc cccggagcgc     9360

cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag     9420

ggcgcaggga cttcctttgt cccaaatctg gcggagccga aatctgggag gcgccgccgc     9480

accccctcta gcgggcgcgg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     9540

agggccttcg tgcgtcgccg cgccgccgtc cccttctcca tctccagcct cggggctgcc     9600

gcagggggac ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt     9660

gaccggcggc tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct     9720

cctgggcaac gtgctggttg ttgtgctgtc tcatcatttt ggcaaagaat tc             9772


<210>  6
<211>  482
<212>  PRT
<213>  Crimean-Congo hemorrhagic fever virus

<400>  6

Met Glu Asn Lys Ile Glu Val Asn Asn Lys Asp Glu Met Asn Arg Trp 
1               5                   10                  15      


Phe Glu Glu Phe Lys Lys Gly Asn Gly Leu Val Asp Thr Phe Thr Asn 
            20                  25                  30          


Ser Tyr Ser Phe Cys Glu Ser Val Pro Asn Leu Asp Arg Phe Val Phe 
        35                  40                  45              


Gln Met Ala Ser Ala Thr Asp Asp Ala Gln Lys Asp Ser Ile Tyr Ala 
    50                  55                  60                  


Ser Ala Leu Val Glu Ala Thr Lys Phe Cys Ala Pro Ile Tyr Glu Cys 
65                  70                  75                  80  


Ala Trp Val Ser Ser Thr Gly Ile Val Lys Lys Gly Leu Glu Trp Phe 
                85                  90                  95      


Glu Lys Asn Ala Gly Thr Ile Lys Ser Trp Asp Glu Ser Tyr Thr Glu 
            100                 105                 110         


Leu Lys Val Asp Val Pro Lys Ile Glu Gln Leu Thr Gly Tyr Gln Gln 
        115                 120                 125             


Ala Ala Leu Lys Trp Arg Lys Asp Ile Gly Phe Arg Val Asn Ala Asn 
    130                 135                 140                 


Thr Ala Ala Leu Ser Asn Lys Val Leu Ala Glu Tyr Lys Val Pro Gly 
145                 150                 155                 160 


Glu Ile Val Met Ser Val Lys Glu Met Leu Ser Asp Met Ile Arg Arg 
                165                 170                 175     


Arg Asn Leu Ile Leu Asn Arg Gly Gly Asp Glu Asn Pro Arg Gly Pro 
            180                 185                 190         


Val Ser His Glu His Val Asp Trp Cys Arg Glu Phe Val Lys Gly Lys 
        195                 200                 205             


Tyr Ile Met Ala Phe Asn Pro Pro Trp Gly Asp Ile Asn Lys Ser Gly 
    210                 215                 220                 


Arg Ser Gly Ile Ala Leu Val Ala Thr Gly Leu Ala Lys Leu Ala Glu 
225                 230                 235                 240 


Thr Glu Gly Lys Gly Ile Phe Asp Glu Ala Lys Lys Thr Val Glu Ala 
                245                 250                 255     


Leu Asn Gly Tyr Leu Asp Lys His Lys Asp Glu Val Asp Arg Ala Ser 
            260                 265                 270         


Ala Asp Ser Met Ile Thr Asn Leu Leu Lys His Ile Ala Lys Ala Gln 
        275                 280                 285             


Glu Leu Tyr Lys Asn Ser Ser Ala Leu Arg Ala Gln Ser Ala Gln Ile 
    290                 295                 300                 


Asp Thr Ala Phe Ser Ser Tyr Tyr Trp Leu Tyr Lys Ala Gly Val Thr 
305                 310                 315                 320 


Pro Glu Thr Phe Pro Thr Val Ser Gln Phe Leu Phe Glu Leu Gly Lys 
                325                 330                 335     


Gln Pro Arg Gly Thr Lys Lys Met Lys Lys Ala Leu Leu Ser Thr Pro 
            340                 345                 350         


Met Lys Trp Gly Lys Lys Leu Tyr Glu Leu Phe Ala Asp Asp Ser Phe 
        355                 360                 365             


Gln Gln Asn Arg Ile Tyr Met His Pro Ala Val Leu Thr Ala Gly Arg 
    370                 375                 380                 


Ile Ser Glu Met Gly Val Cys Phe Gly Thr Ile Pro Val Ala Asn Pro 
385                 390                 395                 400 


Asp Asp Ala Ala Gln Gly Ser Gly His Thr Lys Ser Ile Leu Asn Leu 
                405                 410                 415     


Arg Thr Asn Thr Glu Thr Asn Asn Pro Cys Ala Lys Thr Ile Val Lys 
            420                 425                 430         


Leu Phe Glu Val Gln Lys Thr Gly Phe Asn Ile Gln Asp Met Asp Ile 
        435                 440                 445             


Val Ala Ser Glu His Leu Leu His Gln Ser Leu Val Gly Lys Gln Ser 
    450                 455                 460                 


Pro Phe Gln Asn Ala Tyr Asn Val Lys Gly Asn Ala Thr Ser Ala Asn 
465                 470                 475                 480 


Ile Ile 
        


<210>  7
<211>  3961
<212>  PRT
<213>  Crimean-Congo hemorrhagic fever virus

<400>  7

Met Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Met 
1               5                   10                  15      


Asp Phe Leu Arg Ser Leu Asp Trp Thr Gln Val Ile Ala Gly Gln Tyr 
            20                  25                  30          


Val Ser Asn Pro Arg Phe Asn Ile Ser Asp Tyr Phe Glu Ile Val Arg 
        35                  40                  45              


Gln Pro Gly Asp Gly Asn Cys Phe Tyr His Ser Ile Ala Glu Leu Thr 
    50                  55                  60                  


Met Pro Asn Lys Thr Asp His Ser Tyr His Tyr Ile Lys Arg Leu Thr 
65                  70                  75                  80  


Glu Ser Ala Ala Arg Lys Tyr Tyr Gln Glu Glu Pro Glu Ala Arg Leu 
                85                  90                  95      


Val Gly Leu Ser Leu Glu Asp Tyr Leu Lys Arg Met Leu Ser Asp Asn 
            100                 105                 110         


Glu Trp Gly Ser Thr Leu Glu Ala Ser Met Leu Ala Lys Glu Met Gly 
        115                 120                 125             


Ile Thr Ile Ile Ile Trp Thr Val Ala Ala Ser Asp Glu Val Glu Ala 
    130                 135                 140                 


Ala Gly Ile Lys Phe Gly Asp Gly Asp Val Phe Thr Ala Val Asn Leu 
145                 150                 155                 160 


Leu His Ser Gly Gln Thr His Phe Asp Ala Leu Arg Ile Leu Pro Gln 
                165                 170                 175     


Phe Glu Thr Asp Thr Arg Glu Ala Leu Ser Leu Met Asp Arg Val Ile 
            180                 185                 190         


Ala Val Asp Gln Leu Thr Ser Ser Ser Ser Asp Glu Leu Gln Asp Tyr 
        195                 200                 205             


Glu Asp Leu Ala Leu Ala Leu Thr Ser Ala Glu Glu Ser Asn Arg Arg 
    210                 215                 220                 


Ser Ser Leu Asp Glu Val Thr Leu Ser Lys Lys Gln Ala Glu Ile Leu 
225                 230                 235                 240 


Arg Gln Lys Ala Ser Gln Leu Ser Lys Leu Val Asn Lys Ser Gln Asn 
                245                 250                 255     


Ile Pro Thr Arg Val Gly Arg Val Leu Asp Cys Met Phe Asn Cys Lys 
            260                 265                 270         


Leu Cys Val Glu Ile Ser Ala Asp Thr Leu Ile Leu Arg Pro Glu Ser 
        275                 280                 285             


Lys Glu Lys Ile Gly Glu Ile Met Ser Leu Arg Gln Leu Gly His Lys 
    290                 295                 300                 


Leu Leu Thr Arg Asp Lys Gln Ile Lys Gln Glu Phe Ser Arg Met Lys 
305                 310                 315                 320 


Leu Tyr Val Thr Lys Asp Leu Leu Asp His Leu Asp Val Gly Gly Leu 
                325                 330                 335     


Leu Arg Ala Ala Phe Pro Gly Thr Gly Ile Glu Arg His Met Gln Leu 
            340                 345                 350         


Leu His Ser Glu Met Ile Leu Asp Ile Cys Thr Val Ser Leu Gly Val 
        355                 360                 365             


Met Leu Ser Thr Phe Leu Tyr Gly Ser Asn Asn Lys Asn Lys Lys Lys 
    370                 375                 380                 


Phe Ile Thr Asn Cys Leu Leu Ser Thr Ala Leu Ser Gly Lys Lys Val 
385                 390                 395                 400 


Tyr Lys Val Leu Gly Asn Leu Gly Asn Glu Leu Leu Tyr Lys Ala Pro 
                405                 410                 415     


Arg Lys Ala Leu Ala Thr Val Cys Ser Ala Leu Phe Gly Lys Gln Ile 
            420                 425                 430         


Asn Lys Leu Gln Asn Cys Phe Arg Thr Ile Ser Pro Val Ser Leu Leu 
        435                 440                 445             


Ala Leu Arg Asn Leu Asp Phe Asp Cys Leu Ser Val Gln Asp Tyr Asn 
    450                 455                 460                 


Gly Met Ile Glu Asn Met Ser Lys Leu Asp Asn Thr Asp Val Glu Phe 
465                 470                 475                 480 


Asn His Arg Glu Ile Ala Asp Leu Asn Gln Leu Thr Ser Arg Leu Ile 
                485                 490                 495     


Thr Leu Arg Lys Glu Lys Asp Thr Asp Leu Leu Lys Gln Trp Phe Pro 
            500                 505                 510         


Glu Ser Asp Leu Thr Arg Arg Ser Ile Arg Asn Ala Ala Asn Ala Glu 
        515                 520                 525             


Glu Phe Val Ile Ser Glu Phe Phe Lys Lys Lys Asp Ile Met Lys Phe 
    530                 535                 540                 


Ile Ser Thr Ser Gly Arg Ala Met Ser Ala Gly Lys Ile Gly Asn Val 
545                 550                 555                 560 


Leu Ser Tyr Ala His Asn Leu Tyr Leu Ser Lys Ser Ser Leu Asn Met 
                565                 570                 575     


Thr Ser Glu Asp Ile Ser Gln Leu Leu Ile Glu Ile Lys Arg Leu Tyr 
            580                 585                 590         


Ala Leu Gln Glu Asp Ser Glu Val Glu Pro Ile Ala Ile Ile Cys Asp 
        595                 600                 605             


Gly Ile Glu Ser Asn Met Lys Gln Leu Phe Ala Ile Leu Pro Pro Asp 
    610                 615                 620                 


Cys Ala Arg Glu Cys Glu Val Leu Phe Asp Asp Ile Arg Asn Ser Pro 
625                 630                 635                 640 


Thr His Ser Thr Ala Trp Lys His Ala Leu Arg Leu Lys Gly Thr Ala 
                645                 650                 655     


Tyr Glu Gly Leu Phe Ala Asn Cys Tyr Gly Trp Gln Tyr Ile Pro Glu 
            660                 665                 670         


Asp Ile Lys Pro Ser Leu Thr Met Leu Ile Gln Thr Leu Phe Pro Asp 
        675                 680                 685             


Lys Phe Glu Asp Phe Leu Asp Arg Thr Gln Leu His Pro Glu Phe Arg 
    690                 695                 700                 


Asp Leu Thr Pro Asp Phe Ser Leu Thr Gln Lys Val His Phe Lys Arg 
705                 710                 715                 720 


Asn Gln Ile Pro Ser Val Glu Asn Val Gln Ile Ser Ile Asp Ala Thr 
                725                 730                 735     


Leu Pro Glu Ser Val Glu Ala Val Pro Val Thr Glu Arg Lys Met Phe 
            740                 745                 750         


Pro Leu Pro Glu Thr Pro Leu Ser Glu Val His Ser Ile Glu Arg Ile 
        755                 760                 765             


Met Glu Asn Phe Thr Arg Leu Met His Gly Gly Arg Leu Ser Thr Lys 
    770                 775                 780                 


Lys Arg Asp Gly Asp Pro Ala Glu Gln Gly Asn Gln Gln Ser Ile Thr 
785                 790                 795                 800 


Glu His Glu Ser Ser Ser Ile Ser Ala Phe Lys Asp Tyr Gly Glu Arg 
                805                 810                 815     


Gly Ile Val Glu Glu Asn His Met Lys Phe Ser Gly Glu Asp Gln Leu 
            820                 825                 830         


Glu Thr Arg Gln Leu Leu Leu Val Glu Val Gly Phe Gln Thr Asp Ile 
        835                 840                 845             


Asp Gly Lys Ile Arg Thr Asp His Lys Lys Trp Lys Asp Ile Leu Lys 
    850                 855                 860                 


Leu Leu Glu Leu Leu Gly Ile Lys Cys Ser Phe Ile Ala Cys Ala Asp 
865                 870                 875                 880 


Cys Ser Ser Thr Pro Pro Asp Arg Trp Trp Ile Thr Glu Asp Arg Val 
                885                 890                 895     


Arg Val Leu Lys Asn Ser Val Ser Phe Leu Phe Asn Lys Leu Ser Arg 
            900                 905                 910         


Asn Ser Pro Thr Glu Val Thr Asp Ile Val Val Gly Ala Ile Ser Thr 
        915                 920                 925             


Gln Lys Val Arg Ser Tyr Leu Lys Ala Gly Thr Ala Thr Lys Thr Pro 
    930                 935                 940                 


Val Ser Thr Lys Asp Val Leu Glu Thr Trp Glu Lys Met Lys Glu His 
945                 950                 955                 960 


Ile Leu Asn Arg Pro Thr Gly Leu Thr Leu Pro Thr Ser Leu Glu Gln 
                965                 970                 975     


Ala Met Arg Lys Gly Leu Val Glu Gly Val Val Ile Ser Lys Glu Gly 
            980                 985                 990         


Ser Glu Ser Cys Ile Asn Met Leu  Lys Glu Asn Leu Asp  Arg Ile Thr 
        995                 1000                 1005             


Asp Glu  Phe Glu Arg Thr Lys  Phe Lys His Glu Leu  Thr Gln Asn 
    1010                 1015                 1020             


Ile Thr  Thr Ser Glu Lys Met  Leu Leu Ser Trp Leu  Ser Glu Asp 
    1025                 1030                 1035             


Ile Lys  Ser Ser Arg Cys Gly  Glu Cys Leu Ser Asn  Ile Lys Lys 
    1040                 1045                 1050             


Ala Val  Asp Glu Thr Ala Asn  Leu Ser Glu Lys Ile  Glu Leu Leu 
    1055                 1060                 1065             


Ala Tyr  Asn Leu Gln Leu Thr  Asn His Cys Ser Asn  Cys His Pro 
    1070                 1075                 1080             


Asn Gly  Val Asn Ile Ser Asn  Thr Ser Asn Val Cys  Lys Arg Cys 
    1085                 1090                 1095             


Pro Lys  Ile Glu Val Val Ser  His Cys Glu Asn Lys  Gly Phe Glu 
    1100                 1105                 1110             


Asp Ser  Asn Glu Cys Leu Thr  Asp Leu Asp Arg Leu  Val Arg Leu 
    1115                 1120                 1125             


Thr Leu  Pro Gly Lys Thr Glu  Lys Glu Arg Arg Val  Lys Arg Asn 
    1130                 1135                 1140             


Val Glu  Tyr Leu Ile Lys Leu  Met Met Ser Met Ser  Gly Ile Asp 
    1145                 1150                 1155             


Cys Ile  Lys Tyr Pro Thr Gly  Gln Leu Ile Thr His  Gly Arg Val 
    1160                 1165                 1170             


Ser Ala  Lys His Asn Asp Gly  Asn Leu Lys Asp Arg  Ser Asp Asp 
    1175                 1180                 1185             


Asp Gln  Arg Leu Ala Glu Lys  Ile Asp Thr Val Arg  Lys Glu Leu 
    1190                 1195                 1200             


Ser Glu  Ser Lys Leu Lys Asp  Tyr Ser Thr Tyr Ala  Arg Gly Val 
    1205                 1210                 1215             


Ile Ser  Asn Ser Leu Lys Asn  Leu Ser Arg Gln Gly  Lys Ser Lys 
    1220                 1225                 1230             


Cys Ser  Val Pro Arg Ser Trp  Leu Glu Lys Val Leu  Phe Asp Leu 
    1235                 1240                 1245             


Lys Val  Pro Thr Lys Asp Glu  Glu Val Leu Ile Asn  Ile Arg Asn 
    1250                 1255                 1260             


Ser Leu  Lys Ala Arg Ser Glu  Phe Val Arg Asn Asn  Asp Lys Leu 
    1265                 1270                 1275             


Leu Ile  Arg Ser Lys Glu Glu  Leu Lys Lys Cys Phe  Asp Val Gln 
    1280                 1285                 1290             


Ser Phe  Lys Leu Lys Lys Asn  Lys Gln Pro Val Pro  Phe Gln Val 
    1295                 1300                 1305             


Asp Cys  Ile Leu Phe Lys Glu  Val Ala Ala Glu Cys  Met Lys Arg 
    1310                 1315                 1320             


Tyr Ile  Gly Thr Pro Tyr Glu  Gly Ile Val Asp Thr  Leu Val Ser 
    1325                 1330                 1335             


Leu Ile  Asn Val Leu Thr Arg  Phe Thr Trp Phe Gln  Glu Val Val 
    1340                 1345                 1350             


Leu Tyr  Gly Lys Ile Cys Glu  Thr Phe Leu Arg Cys  Cys Thr Glu 
    1355                 1360                 1365             


Phe Asn  Arg Ser Gly Val Lys  Leu Val Lys Ile Arg  His Cys Asn 
    1370                 1375                 1380             


Ile Asn  Leu Ser Val Lys Leu  Pro Ser Asn Lys Lys  Glu Asn Met 
    1385                 1390                 1395             


Leu Cys  Cys Leu Tyr Ser Gly  Asn Met Glu Leu Leu  Gln Gly Pro 
    1400                 1405                 1410             


Phe Tyr  Leu Asn Arg Arg Gln  Ala Val Leu Gly Ser  Ser Tyr Leu 
    1415                 1420                 1425             


Tyr Ile  Val Ile Thr Leu Tyr  Ile Gln Val Leu Gln  Gln Tyr Arg 
    1430                 1435                 1440             


Cys Leu  Glu Val Ile Asn Ser  Val Ser Glu Lys Thr  Leu Gln Asp 
    1445                 1450                 1455             


Ile Glu  Asn His Ser Met Thr  Leu Leu Glu Asp Ser  Phe Arg Glu 
    1460                 1465                 1470             


Ile Thr  Phe Ala Leu Glu Gly  Arg Phe Glu Glu Ser  Tyr Lys Ile 
    1475                 1480                 1485             


Arg Thr  Ser Arg Cys Arg Ala  Ser Gly Asn Phe Leu  Asn Arg Ser 
    1490                 1495                 1500             


Ser Arg  Asp His Phe Ile Ser  Val Val Ser Gly Leu  Asn Leu Val 
    1505                 1510                 1515             


Tyr Gly  Phe Leu Ile Lys Asp  Asn Leu Leu Ala Asn  Ser Gln Gln 
    1520                 1525                 1530             


Gln Asn  Lys Gln Leu Gln Met  Leu Arg Phe Gly Met  Leu Ala Gly 
    1535                 1540                 1545             


Leu Ser  Arg Leu Val Cys Pro  Asn Glu Leu Gly Lys  Lys Phe Ser 
    1550                 1555                 1560             


Thr Ser  Cys Arg Arg Ile Glu  Asp Asn Ile Ala Arg  Leu Tyr Leu 
    1565                 1570                 1575             


Gln Thr  Ser Ile Tyr Cys Ser  Val Arg Asp Val Glu  Asp Asn Val 
    1580                 1585                 1590             


Lys His  Trp Lys Gln Arg Asp  Leu Cys Pro Glu Val  Thr Ile Pro 
    1595                 1600                 1605             


Cys Phe  Thr Val Tyr Gly Thr  Phe Val Asn Ser Asp  Arg Gln Leu 
    1610                 1615                 1620             


Ile Phe  Asp Ile Tyr Asn Val  His Ile Tyr Asn Lys  Glu Met Asp 
    1625                 1630                 1635             


Asn Phe  Asp Glu Gly Cys Ile  Ser Val Leu Glu Glu  Thr Ala Glu 
    1640                 1645                 1650             


Arg His  Met Leu Trp Glu Leu  Asp Leu Met Asn Ser  Leu Cys Ser 
    1655                 1660                 1665             


Asp Glu  Lys Lys Asp Thr Arg  Thr Ala Arg Leu Leu  Leu Gly Cys 
    1670                 1675                 1680             


Pro Asn  Val Arg Lys Ala Ala  Asn Arg Glu Gly Lys  Lys Leu Leu 
    1685                 1690                 1695             


Lys Leu  Asn Ser Asp Thr Ser  Thr Asp Thr Gln Ser  Ile Ala Ser 
    1700                 1705                 1710             


Glu Val  Ser Asp Arg Arg Ser  Tyr Ser Ser Ser Lys  Ser Arg Ile 
    1715                 1720                 1725             


Arg Ser  Ile Phe Gly Arg Tyr  Asn Ser Gln Lys Lys  Pro Phe Glu 
    1730                 1735                 1740             


Leu Arg  Ser Gly Leu Glu Val  Phe Asn Asp Pro Phe  Asn Asp Tyr 
    1745                 1750                 1755             


Gln Gln  Ala Ile Thr Asp Ile  Cys Gln Phe Ser Glu  Tyr Thr Pro 
    1760                 1765                 1770             


Asn Lys  Glu Ser Ile Leu Lys  Asp Cys Leu Gln Ile  Ile Arg Lys 
    1775                 1780                 1785             


Asn Pro  Ser His Thr Met Gly  Ser Phe Glu Leu Ile  Gln Ala Ile 
    1790                 1795                 1800             


Ser Glu  Phe Gly Met Ser Lys  Phe Pro Pro Glu Asn  Ile Asp Lys 
    1805                 1810                 1815             


Ala Arg  Arg Asp Pro Lys Asn  Trp Val Ser Ile Ser  Glu Val Thr 
    1820                 1825                 1830             


Glu Thr  Thr Ser Ile Val Ala  Ser Pro Arg Thr His  Met Met Leu 
    1835                 1840                 1845             


Lys Asp  Cys Phe Lys Ile Ile  Leu Gly Thr Glu Asn  Lys Lys Ile 
    1850                 1855                 1860             


Val Lys  Met Leu Arg Gly Lys  Leu Lys Lys Leu Gly  Ala Ile Ser 
    1865                 1870                 1875             


Thr Asn  Ile Glu Ile Gly Lys  Arg Asp Cys Leu Asp  Leu Leu Ser 
    1880                 1885                 1890             


Thr Val  Asp Gly Leu Thr Asp  Gln Gln Lys Glu Asn  Ile Val Asn 
    1895                 1900                 1905             


Gly Ile  Phe Glu Pro Ser Lys  Leu Ser Phe Tyr His  Trp Lys Glu 
    1910                 1915                 1920             


Leu Val  Lys Lys Asn Ile Asp  Glu Val Leu Leu Thr  Glu Asp Gly 
    1925                 1930                 1935             


Asn Leu  Ile Phe Cys Trp Leu  Lys Thr Ile Ser Ser  Ser Val Lys 
    1940                 1945                 1950             


Gly Ser  Leu Lys Lys Arg Leu  Lys Phe Met Asn Ile  His Ser Pro 
    1955                 1960                 1965             


Glu Leu  Met Pro Glu Asn Cys  Leu Phe Ser Ser Glu  Glu Phe Asn 
    1970                 1975                 1980             


Glu Leu  Ile Lys Leu Lys Lys  Leu Leu Leu Asn Glu  Gln Gln Asp 
    1985                 1990                 1995             


Glu Gln  Glu Leu Lys Gln Asp  Leu Leu Ile Ser Ser  Trp Ile Lys 
    2000                 2005                 2010             


Cys Ile  Thr Ala Cys Lys Asp  Phe Ala Ser Ile Asn  Asp Lys Ile 
    2015                 2020                 2025             


Gln Lys  Phe Ile Tyr His Leu  Ser Glu Glu Leu Tyr  Asp Ile Arg 
    2030                 2035                 2040             


Leu Gln  His Leu Glu Leu Ser  Lys Leu Lys Gln Glu  His Pro Ser 
    2045                 2050                 2055             


Val Ser  Phe Thr Lys Glu Glu  Val Leu Ile Lys Arg  Leu Glu Lys 
    2060                 2065                 2070             


Asn Phe  Leu Lys Gln His Asn  Leu Glu Ile Met Glu  Thr Val Asn 
    2075                 2080                 2085             


Leu Val  Phe Phe Ala Ala Leu  Ser Ala Pro Trp Cys  Leu His Tyr 
    2090                 2095                 2100             


Lys Ala  Leu Glu Ser Tyr Leu  Val Arg His Pro Glu  Ile Leu Asp 
    2105                 2110                 2115             


Cys Gly  Ser Lys Glu Asp Cys  Lys Leu Thr Leu Leu  Asp Leu Ser 
    2120                 2125                 2130             


Val Ser  Lys Leu Leu Val Cys  Leu Tyr Gln Lys Asp  Asp Glu Glu 
    2135                 2140                 2145             


Leu Ile  Asn Ser Ser Ser Leu  Lys Leu Gly Phe Leu  Val Lys Tyr 
    2150                 2155                 2160             


Val Val  Thr Leu Phe Thr Ser  Asn Gly Glu Pro Phe  Ser Leu Ser 
    2165                 2170                 2175             


Leu Asn  Asp Gly Gly Leu Asp  Leu Asp Leu His Lys  Thr Thr Asp 
    2180                 2185                 2190             


Glu Lys  Leu Leu His Gln Thr  Lys Ile Val Phe Ala  Lys Ile Gly 
    2195                 2200                 2205             


Leu Ser  Gly Asn Ser Tyr Asp  Phe Ile Trp Thr Thr  Gln Met Ile 
    2210                 2215                 2220             


Ala Asn  Ser Asn Phe Asn Val  Cys Lys Arg Leu Thr  Gly Arg Ser 
    2225                 2230                 2235             


Thr Gly  Glu Arg Leu Pro Arg  Ser Val Arg Ser Lys  Val Ile Tyr 
    2240                 2245                 2250             


Glu Met  Val Lys Leu Val Gly  Glu Thr Gly Met Ala  Ile Leu Gln 
    2255                 2260                 2265             


Gln Leu  Ala Phe Ala Gln Ala  Leu Asn Tyr Glu His  Arg Phe Tyr 
    2270                 2275                 2280             


Ala Val  Leu Ala Pro Lys Ala  Gln Leu Gly Gly Ala  Arg Asp Leu 
    2285                 2290                 2295             


Leu Val  Gln Glu Thr Gly Thr  Lys Val Met His Ala  Thr Thr Glu 
    2300                 2305                 2310             


Met Phe  Ser Arg Asn Leu Leu  Lys Thr Thr Ser Asp  Asp Gly Leu 
    2315                 2320                 2325             


Thr Asn  Pro His Leu Lys Glu  Thr Ile Leu Asn Val  Gly Leu Asp 
    2330                 2335                 2340             


Cys Leu  Ala Asn Met Arg Asn  Leu Asp Gly Lys Pro  Ile Ser Glu 
    2345                 2350                 2355             


Gly Ser  Asn Leu Val Asn Phe  Tyr Lys Val Ile Cys  Ile Ser Gly 
    2360                 2365                 2370             


Asp Asn  Thr Lys Trp Gly Pro  Ile His Cys Cys Ser  Phe Phe Ser 
    2375                 2380                 2385             


Gly Met  Met Gln Gln Val Leu  Lys Asn Val Pro Asp  Trp Cys Ser 
    2390                 2395                 2400             


Phe Tyr  Lys Leu Thr Phe Ile  Lys Asn Leu Cys Arg  Gln Val Glu 
    2405                 2410                 2415             


Ile Pro  Ala Gly Ser Ile Lys  Lys Ile Leu Asn Val  Leu Arg Tyr 
    2420                 2425                 2430             


Arg Leu  Cys Ser Lys Gly Gly  Val Glu Gln His Ser  Glu Glu Asp 
    2435                 2440                 2445             


Leu Arg  Arg Leu Leu Thr Asp  Asn Leu Asp Ser Trp  Asp Gly Asn 
    2450                 2455                 2460             


Asp Thr  Val Lys Phe Leu Val  Thr Thr Tyr Ile Ser  Lys Gly Leu 
    2465                 2470                 2475             


Met Ala  Leu Asn Ser Tyr Asn  His Met Gly Gln Gly  Ile His His 
    2480                 2485                 2490             


Ala Thr  Ser Ser Val Leu Thr  Ser Leu Ala Ala Val  Leu Phe Glu 
    2495                 2500                 2505             


Glu Leu  Ala Ile Phe Tyr Leu  Lys Arg Ser Leu Pro  Gln Thr Thr 
    2510                 2515                 2520             


Val His  Val Glu His Ala Gly  Ser Ser Asp Asp Tyr  Ala Lys Cys 
    2525                 2530                 2535             


Ile Val  Val Thr Gly Ile Leu  Ser Lys Glu Leu Tyr  Ser Gln Tyr 
    2540                 2545                 2550             


Asp Glu  Thr Phe Trp Lys His  Ala Cys Arg Leu Lys  Asn Phe Thr 
    2555                 2560                 2565             


Ala Ala  Val Gln Arg Cys Cys  Gln Met Lys Asp Ser  Ala Lys Thr 
    2570                 2575                 2580             


Leu Val  Ser Asp Cys Phe Leu  Glu Phe Tyr Ser Glu  Phe Met Met 
    2585                 2590                 2595             


Gly Tyr  Arg Val Thr Pro Ala  Val Ile Lys Phe Met  Phe Thr Gly 
    2600                 2605                 2610             


Leu Ile  Asn Ser Ser Val Thr  Ser Pro Gln Ser Leu  Met Gln Ala 
    2615                 2620                 2625             


Cys Gln  Val Ser Ser Gln Gln  Ala Met Tyr Asn Ser  Val Pro Leu 
    2630                 2635                 2640             


Val Thr  Asn Thr Ala Phe Thr  Leu Leu Arg Gln Gln  Ile Phe Phe 
    2645                 2650                 2655             


Asn His  Val Glu Asp Phe Ile  Arg Arg Tyr Gly Ile  Leu Thr Leu 
    2660                 2665                 2670             


Gly Thr  Leu Ser Pro Phe Gly  Arg Leu Phe Val Pro  Thr Tyr Ser 
    2675                 2680                 2685             


Gly Leu  Val Ser Ser Ala Val  Ala Leu Glu Asp Ala  Glu Val Ile 
    2690                 2695                 2700             


Ala Arg  Ala Ala Gln Thr Leu  Gln Met Asn Ser Val  Ser Ile Gln 
    2705                 2710                 2715             


Ser Ser  Ser Leu Thr Thr Leu  Asp Ser Leu Gly Arg  Ser Arg Thr 
    2720                 2725                 2730             


Ser Ser  Thr Ala Glu Asp Ser  Ser Ser Val Ser Asp  Thr Thr Ala 
    2735                 2740                 2745             


Ala Ser  His Asp Ser Gly Ser  Ser Ser Ser Ser Phe  Ser Phe Glu 
    2750                 2755                 2760             


Leu Asn  Arg Pro Leu Ser Glu  Thr Glu Leu Gln Phe  Ile Lys Ala 
    2765                 2770                 2775             


Leu Ser  Ser Leu Lys Ser Thr  Gln Ala Cys Glu Val  Ile Gln Asn 
    2780                 2785                 2790             


Arg Ile  Thr Gly Leu Tyr Cys  Asn Ser Asn Glu Gly  Pro Leu Asp 
    2795                 2800                 2805             


Arg His  Asn Val Ile Tyr Ser  Ser Arg Met Ala Asp  Ser Cys Asp 
    2810                 2815                 2820             


Trp Leu  Lys Asp Gly Lys Arg  Arg Gly Asn Leu Glu  Leu Ala Asn 
    2825                 2830                 2835             


Arg Ile  Gln Ser Val Leu Cys  Ile Leu Ile Ala Gly  Tyr Tyr Arg 
    2840                 2845                 2850             


Ser Phe  Gly Gly Glu Gly Thr  Glu Lys Gln Val Lys  Ala Ser Leu 
    2855                 2860                 2865             


Asn Arg  Asp Asp Asn Lys Ile  Ile Glu Asp Pro Met  Ile Gln Leu 
    2870                 2875                 2880             


Ile Pro  Glu Lys Leu Arg Arg  Glu Leu Glu Arg Leu  Gly Val Ser 
    2885                 2890                 2895             


Arg Met  Glu Val Asp Glu Leu  Met Pro Ser Ile Ser  Pro Asp Asp 
    2900                 2905                 2910             


Thr Leu  Ala Gln Leu Val Ala  Lys Lys Leu Ile Ser  Leu Asn Val 
    2915                 2920                 2925             


Ser Thr  Glu Glu Tyr Ser Ala  Glu Val Ser Arg Leu  Lys Gln Thr 
    2930                 2935                 2940             


Leu Thr  Ala Arg Asn Val Leu  His Gly Leu Ala Gly  Gly Ile Lys 
    2945                 2950                 2955             


Glu Leu  Ser Leu Pro Ile Tyr  Thr Ile Phe Met Lys  Ser Tyr Phe 
    2960                 2965                 2970             


Phe Lys  Asp Asn Val Phe Leu  Ser Leu Thr Asp Arg  Trp Ser Thr 
    2975                 2980                 2985             


Lys His  Ser Thr Asn Tyr Arg  Asp Ser Cys Gly Lys  Gln Leu Lys 
    2990                 2995                 3000             


Gly Arg  Ile Ile Thr Lys Tyr  Thr His Trp Leu Asp  Thr Phe Leu 
    3005                 3010                 3015             


Gly Cys  Ser Val Ser Ile Asn  Arg His Thr Thr Val  Lys Glu Pro 
    3020                 3025                 3030             


Ser Leu  Phe Asn Pro Asn Ile  Arg Cys Val Asn Leu  Ile Thr Phe 
    3035                 3040                 3045             


Glu Asp  Gly Leu Arg Glu Leu  Ser Val Ile Gln Ser  His Leu Lys 
    3050                 3055                 3060             


Val Phe  Glu Asn Glu Phe Thr  Asn Leu Asn Leu Gln  Phe Ser Asp 
    3065                 3070                 3075             


Pro Asn  Arg Gln Lys Leu Arg  Ile Val Glu Ser Arg  Pro Ala Glu 
    3080                 3085                 3090             


Ser Glu  Leu Glu Ala Asn Arg  Ala Val Ile Val Lys  Thr Lys Leu 
    3095                 3100                 3105             


Phe Ser  Ala Thr Glu Gln Val  Arg Leu Ser Asn Asn  Pro Ala Val 
    3110                 3115                 3120             


Val Met  Gly Tyr Leu Leu Asp  Glu Ser Ala Ile Ser  Glu Val Lys 
    3125                 3130                 3135             


Pro Thr  Lys Val Asp Phe Ser  Asn Leu Leu Lys Asp  Arg Phe Lys 
    3140                 3145                 3150             


Ile Met  Gln Phe Phe Pro Ser  Val Phe Thr Leu Ile  Lys Met Leu 
    3155                 3160                 3165             


Thr Asp  Glu Ser Ser Asp Ser  Glu Lys Ser Gly Leu  Ser Pro Asp 
    3170                 3175                 3180             


Leu Gln  Gln Val Ala Arg Tyr  Ser Asn His Leu Thr  Leu Leu Ser 
    3185                 3190                 3195             


Arg Met  Ile Gln Gln Ala Lys  Pro Thr Val Thr Val  Phe Tyr Met 
    3200                 3205                 3210             


Leu Lys  Gly Asn Leu Met Asn  Thr Glu Pro Thr Val  Ala Glu Leu 
    3215                 3220                 3225             


Val Ser  Tyr Gly Ile Lys Glu  Gly Arg Phe Phe Arg  Leu Ser Asp 
    3230                 3235                 3240             


Thr Gly  Val Asp Ala Ser Thr  Tyr Ser Val Lys Tyr  Trp Lys Ile 
    3245                 3250                 3255             


Leu His  Cys Ile Ser Ala Ile  Gly Cys Leu Pro Leu  Ser Gln Ala 
    3260                 3265                 3270             


Asp Lys  Ser Ser Leu Leu Met  Ser Phe Leu Asn Trp  Arg Val Asn 
    3275                 3280                 3285             


Met Asp  Ile Arg Thr Ser Asp  Cys Pro Leu Ser Ser  His Glu Ala 
    3290                 3295                 3300             


Ser Ile  Leu Ser Glu Phe Asp  Gly Gln Val Ile Ala  Asn Ile Leu 
    3305                 3310                 3315             


Ala Ser  Glu Leu Ser Ser Val  Lys Arg Asp Ser Glu  Arg Glu Gly 
    3320                 3325                 3330             


Leu Thr  Asp Leu Leu Asp Tyr  Leu Asn Ser Pro Thr  Glu Leu Leu 
    3335                 3340                 3345             


Lys Lys  Lys Pro Tyr Leu Gly  Thr Thr Cys Lys Phe  Asn Thr Trp 
    3350                 3355                 3360             


Gly Asp  Ser Asn Arg Ser Gly  Lys Phe Thr Tyr Ser  Ser Arg Ser 
    3365                 3370                 3375             


Gly Glu  Ser Ile Gly Ile Phe  Ile Ala Gly Lys Leu  His Ile His 
    3380                 3385                 3390             


Leu Ser  Ser Glu Ser Val Ala  Leu Leu Cys Glu Thr  Glu Arg Gln 
    3395                 3400                 3405             


Val Leu  Ser Trp Met Ser Lys  Arg Arg Thr Glu Val  Ile Thr Lys 
    3410                 3415                 3420             


Glu Gln  His Gln Leu Phe Leu  Ser Leu Leu Pro Gln  Ser His Glu 
    3425                 3430                 3435             


Cys Leu  Gln Lys His Lys Asp  Gly Ser Ala Leu Ser  Val Ile Pro 
    3440                 3445                 3450             


Asp Ser  Ser Asn Pro Arg Leu  Leu Lys Phe Val Pro  Leu Lys Lys 
    3455                 3460                 3465             


Gly Leu  Ala Val Val Lys Ile  Lys Lys Gln Ile Leu  Thr Val Lys 
    3470                 3475                 3480             


Lys Gln  Val Val Phe Asp Ala  Glu Ser Glu Pro Arg  Leu Gln Trp 
    3485                 3490                 3495             


Gly His  Gly Cys Leu Ser Ile  Val Tyr Asp Glu Thr  Asp Thr Gln 
    3500                 3505                 3510             


Thr Thr  Tyr His Glu Asn Leu  Leu Lys Val Lys His  Leu Val Asp 
    3515                 3520                 3525             


Cys Ser  Thr Asp Arg Lys Lys  Leu Leu Pro Gln Ser  Val Phe Ser 
    3530                 3535                 3540             


Asp Ser  Lys Val Val Leu Ser  Arg Ile Lys Phe Lys  Thr Glu Leu 
    3545                 3550                 3555             


Leu Leu  Asn Ser Leu Thr Leu  Leu His Cys Phe Leu  Lys His Ala 
    3560                 3565                 3570             


Pro Ser  Asp Ala Ile Met Glu  Val Glu Ser Lys Ser  Ser Leu Leu 
    3575                 3580                 3585             


His Lys  Tyr Leu Lys Ser Gly  Gly Val Arg Gln Arg  Asn Thr Glu 
    3590                 3595                 3600             


Val Leu  Phe Arg Glu Lys Leu  Asn Lys Val Val Ile  Lys Asp Asn 
    3605                 3610                 3615             


Leu Glu  Gln Gly Val Glu Glu  Glu Ile Glu Phe Cys  Asn Asn Leu 
    3620                 3625                 3630             


Thr Lys  Thr Val Ser Glu Asn  Pro Leu Pro Leu Ser  Cys Trp Ser 
    3635                 3640                 3645             


Glu Val  Gln Asn Tyr Ile Glu  Asp Ile Gly Phe Asn  Asn Val Leu 
    3650                 3655                 3660             


Val Asn  Ile Asp Arg Asn Thr  Val Lys Ser Glu Leu  Leu Trp Lys 
    3665                 3670                 3675             


Phe Thr  Leu Asp Thr Asn Val  Ser Thr Thr Ser Thr  Ile Lys Asp 
    3680                 3685                 3690             


Val Arg  Thr Leu Val Ser Tyr  Val Ser Thr Glu Thr  Ile Pro Lys 
    3695                 3700                 3705             


Phe Leu  Leu Ala Phe Leu Leu  Tyr Glu Glu Val Leu  Met Asn Leu 
    3710                 3715                 3720             


Ile Asn  Gln Cys Lys Ala Val  Lys Glu Leu Ile Asn  Ser Thr Gly 
    3725                 3730                 3735             


Leu Ser  Asp Leu Glu Leu Glu  Ser Leu Leu Thr Leu  Cys Ala Phe 
    3740                 3745                 3750             


Tyr Phe  Gln Ser Glu Cys Ser  Lys Arg Asp Gly Pro  Arg Cys Ser 
    3755                 3760                 3765             


Phe Ala  Ala Leu Leu Ser Leu  Ile His Glu Asp Trp  Gln Arg Ile 
    3770                 3775                 3780             


Gly Lys  Asn Ile Leu Val Arg  Ala Asn Asn Glu Leu  Gly Asp Val 
    3785                 3790                 3795             


Ser Leu  Lys Val Asn Ile Val  Leu Val Pro Leu Lys  Asp Met Ser 
    3800                 3805                 3810             


Lys Pro  Lys Ser Glu Arg Val  Val Met Ala Arg Arg  Ser Leu Asn 
    3815                 3820                 3825             


His Ala  Leu Ser Leu Met Phe  Leu Asp Glu Met Ser  Leu Pro Glu 
    3830                 3835                 3840             


Leu Lys  Ser Leu Ser Val Asn  Cys Lys Met Gly Asn  Phe Glu Gly 
    3845                 3850                 3855             


Gln Glu  Cys Phe Glu Phe Thr  Ile Leu Lys Asp Asn  Ser Ala Arg 
    3860                 3865                 3870             


Leu Asp  Tyr Asn Lys Leu Ile  Asp His Cys Val Asp  Met Glu Lys 
    3875                 3880                 3885             


Lys Arg  Glu Ala Val Arg Ala  Val Glu Asp Leu Ile  Leu Met Leu 
    3890                 3895                 3900             


Thr Gly  Arg Ala Val Lys Pro  Ser Ala Val Thr Gln  Phe Val His 
    3905                 3910                 3915             


Gly Asp  Glu Gln Cys Gln Glu  Gln Ile Ser Leu Asp  Asp Leu Met 
    3920                 3925                 3930             


Ala Asn  Asp Thr Val Thr Asp  Phe Pro Asp Arg Glu  Ala Glu Ala 
    3935                 3940                 3945             


Leu Lys  Thr Gly Asn Leu Gly  Phe Asn Trp Asp Ser  Asp 
    3950                 3955                 3960     


<210>  8
<211>  3946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Ile, Arg, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa =  Gln or Arg

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa =  Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa =  Cys, Ala, Ser or Arg

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa =  Pro, Asp or Thr

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  Xaa =  Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  Xaa =  Glu or Val

<220>
<221>  MISC_FEATURE
<222>  (129)..(129)
<223>  Xaa =  Ala, Arg or Gly

<400>  8

Met Asp Phe Leu Arg Ser Leu Asp Trp Thr Gln Val Xaa Ala Gly Xaa 
1               5                   10                  15      


Tyr Xaa Ser Asn Pro Arg Phe Asn Ile Ser Asp Tyr Phe Glu Ile Val 
            20                  25                  30          


Arg Gln Pro Gly Asp Gly Asn Xaa Phe Tyr His Ser Ile Ala Glu Leu 
        35                  40                  45              


Thr Met Pro Asn Lys Thr Asp His Ser Tyr His Tyr Ile Lys Arg Leu 
    50                  55                  60                  


Thr Glu Ser Ala Ala Arg Lys Tyr Tyr Gln Glu Glu Xaa Glu Ala Arg 
65                  70                  75                  80  


Leu Val Gly Leu Ser Leu Glu Asp Tyr Leu Lys Arg Met Leu Ser Asp 
                85                  90                  95      


Asn Glu Trp Gly Ser Thr Leu Glu Ala Ser Met Leu Ala Lys Glu Met 
            100                 105                 110         


Gly Ile Thr Ile Ile Ile Trp Xaa Val Ala Ala Ser Asp Glu Val Xaa 
        115                 120                 125             


Xaa Ala Gly Ile Lys Phe Gly Asp Gly Asp Val Phe Thr Ala Val Asn 
    130                 135                 140                 


Leu Leu His Ser Gly Gln Thr His Phe Asp Ala Leu Arg Ile Leu Pro 
145                 150                 155                 160 


Gln Phe Glu Thr Asp Thr Arg Glu Ala Leu Ser Leu Met Asp Arg Val 
                165                 170                 175     


Ile Ala Val Asp Gln Leu Thr Ser Ser Ser Ser Asp Glu Leu Gln Asp 
            180                 185                 190         


Tyr Glu Asp Leu Ala Leu Ala Leu Thr Ser Ala Glu Glu Ser Asn Arg 
        195                 200                 205             


Arg Ser Ser Leu Asp Glu Val Thr Leu Ser Lys Lys Gln Ala Glu Ile 
    210                 215                 220                 


Leu Arg Gln Lys Ala Ser Gln Leu Ser Lys Leu Val Asn Lys Ser Gln 
225                 230                 235                 240 


Asn Ile Pro Thr Arg Val Gly Arg Val Leu Asp Cys Met Phe Asn Cys 
                245                 250                 255     


Lys Leu Cys Val Glu Ile Ser Ala Asp Thr Leu Ile Leu Arg Pro Glu 
            260                 265                 270         


Ser Lys Glu Lys Ile Gly Glu Ile Met Ser Leu Arg Gln Leu Gly His 
        275                 280                 285             


Lys Leu Leu Thr Arg Asp Lys Gln Ile Lys Gln Glu Phe Ser Arg Met 
    290                 295                 300                 


Lys Leu Tyr Val Thr Lys Asp Leu Leu Asp His Leu Asp Val Gly Gly 
305                 310                 315                 320 


Leu Leu Arg Ala Ala Phe Pro Gly Thr Gly Ile Glu Arg His Met Gln 
                325                 330                 335     


Leu Leu His Ser Glu Met Ile Leu Asp Ile Cys Thr Val Ser Leu Gly 
            340                 345                 350         


Val Met Leu Ser Thr Phe Leu Tyr Gly Ser Asn Asn Lys Asn Lys Lys 
        355                 360                 365             


Lys Phe Ile Thr Asn Cys Leu Leu Ser Thr Ala Leu Ser Gly Lys Lys 
    370                 375                 380                 


Val Tyr Lys Val Leu Gly Asn Leu Gly Asn Glu Leu Leu Tyr Lys Ala 
385                 390                 395                 400 


Pro Arg Lys Ala Leu Ala Thr Val Cys Ser Ala Leu Phe Gly Lys Gln 
                405                 410                 415     


Ile Asn Lys Leu Gln Asn Cys Phe Arg Thr Ile Ser Pro Val Ser Leu 
            420                 425                 430         


Leu Ala Leu Arg Asn Leu Asp Phe Asp Cys Leu Ser Val Gln Asp Tyr 
        435                 440                 445             


Asn Gly Met Ile Glu Asn Met Ser Lys Leu Asp Asn Thr Asp Val Glu 
    450                 455                 460                 


Phe Asn His Arg Glu Ile Ala Asp Leu Asn Gln Leu Thr Ser Arg Leu 
465                 470                 475                 480 


Ile Thr Leu Arg Lys Glu Lys Asp Thr Asp Leu Leu Lys Gln Trp Phe 
                485                 490                 495     


Pro Glu Ser Asp Leu Thr Arg Arg Ser Ile Arg Asn Ala Ala Asn Ala 
            500                 505                 510         


Glu Glu Phe Val Ile Ser Glu Phe Phe Lys Lys Lys Asp Ile Met Lys 
        515                 520                 525             


Phe Ile Ser Thr Ser Gly Arg Ala Met Ser Ala Gly Lys Ile Gly Asn 
    530                 535                 540                 


Val Leu Ser Tyr Ala His Asn Leu Tyr Leu Ser Lys Ser Ser Leu Asn 
545                 550                 555                 560 


Met Thr Ser Glu Asp Ile Ser Gln Leu Leu Ile Glu Ile Lys Arg Leu 
                565                 570                 575     


Tyr Ala Leu Gln Glu Asp Ser Glu Val Glu Pro Ile Ala Ile Ile Cys 
            580                 585                 590         


Asp Gly Ile Glu Ser Asn Met Lys Gln Leu Phe Ala Ile Leu Pro Pro 
        595                 600                 605             


Asp Cys Ala Arg Glu Cys Glu Val Leu Phe Asp Asp Ile Arg Asn Ser 
    610                 615                 620                 


Pro Thr His Ser Thr Ala Trp Lys His Ala Leu Arg Leu Lys Gly Thr 
625                 630                 635                 640 


Ala Tyr Glu Gly Leu Phe Ala Asn Cys Tyr Gly Trp Gln Tyr Ile Pro 
                645                 650                 655     


Glu Asp Ile Lys Pro Ser Leu Thr Met Leu Ile Gln Thr Leu Phe Pro 
            660                 665                 670         


Asp Lys Phe Glu Asp Phe Leu Asp Arg Thr Gln Leu His Pro Glu Phe 
        675                 680                 685             


Arg Asp Leu Thr Pro Asp Phe Ser Leu Thr Gln Lys Val His Phe Lys 
    690                 695                 700                 


Arg Asn Gln Ile Pro Ser Val Glu Asn Val Gln Ile Ser Ile Asp Ala 
705                 710                 715                 720 


Thr Leu Pro Glu Ser Val Glu Ala Val Pro Val Thr Glu Arg Lys Met 
                725                 730                 735     


Phe Pro Leu Pro Glu Thr Pro Leu Ser Glu Val His Ser Ile Glu Arg 
            740                 745                 750         


Ile Met Glu Asn Phe Thr Arg Leu Met His Gly Gly Arg Leu Ser Thr 
        755                 760                 765             


Lys Lys Arg Asp Gly Asp Pro Ala Glu Gln Gly Asn Gln Gln Ser Ile 
    770                 775                 780                 


Thr Glu His Glu Ser Ser Ser Ile Ser Ala Phe Lys Asp Tyr Gly Glu 
785                 790                 795                 800 


Arg Gly Ile Val Glu Glu Asn His Met Lys Phe Ser Gly Glu Asp Gln 
                805                 810                 815     


Leu Glu Thr Arg Gln Leu Leu Leu Val Glu Val Gly Phe Gln Thr Asp 
            820                 825                 830         


Ile Asp Gly Lys Ile Arg Thr Asp His Lys Lys Trp Lys Asp Ile Leu 
        835                 840                 845             


Lys Leu Leu Glu Leu Leu Gly Ile Lys Cys Ser Phe Ile Ala Cys Ala 
    850                 855                 860                 


Asp Cys Ser Ser Thr Pro Pro Asp Arg Trp Trp Ile Thr Glu Asp Arg 
865                 870                 875                 880 


Val Arg Val Leu Lys Asn Ser Val Ser Phe Leu Phe Asn Lys Leu Ser 
                885                 890                 895     


Arg Asn Ser Pro Thr Glu Val Thr Asp Ile Val Val Gly Ala Ile Ser 
            900                 905                 910         


Thr Gln Lys Val Arg Ser Tyr Leu Lys Ala Gly Thr Ala Thr Lys Thr 
        915                 920                 925             


Pro Val Ser Thr Lys Asp Val Leu Glu Thr Trp Glu Lys Met Lys Glu 
    930                 935                 940                 


His Ile Leu Asn Arg Pro Thr Gly Leu Thr Leu Pro Thr Ser Leu Glu 
945                 950                 955                 960 


Gln Ala Met Arg Lys Gly Leu Val Glu Gly Val Val Ile Ser Lys Glu 
                965                 970                 975     


Gly Ser Glu Ser Cys Ile Asn Met Leu Lys Glu Asn Leu Asp Arg Ile 
            980                 985                 990         


Thr Asp Glu Phe Glu Arg Thr Lys  Phe Lys His Glu Leu  Thr Gln Asn 
        995                 1000                 1005             


Ile Thr  Thr Ser Glu Lys Met  Leu Leu Ser Trp Leu  Ser Glu Asp 
    1010                 1015                 1020             


Ile Lys  Ser Ser Arg Cys Gly  Glu Cys Leu Ser Asn  Ile Lys Lys 
    1025                 1030                 1035             


Ala Val  Asp Glu Thr Ala Asn  Leu Ser Glu Lys Ile  Glu Leu Leu 
    1040                 1045                 1050             


Ala Tyr  Asn Leu Gln Leu Thr  Asn His Cys Ser Asn  Cys His Pro 
    1055                 1060                 1065             


Asn Gly  Val Asn Ile Ser Asn  Thr Ser Asn Val Cys  Lys Arg Cys 
    1070                 1075                 1080             


Pro Lys  Ile Glu Val Val Ser  His Cys Glu Asn Lys  Gly Phe Glu 
    1085                 1090                 1095             


Asp Ser  Asn Glu Cys Leu Thr  Asp Leu Asp Arg Leu  Val Arg Leu 
    1100                 1105                 1110             


Thr Leu  Pro Gly Lys Thr Glu  Lys Glu Arg Arg Val  Lys Arg Asn 
    1115                 1120                 1125             


Val Glu  Tyr Leu Ile Lys Leu  Met Met Ser Met Ser  Gly Ile Asp 
    1130                 1135                 1140             


Cys Ile  Lys Tyr Pro Thr Gly  Gln Leu Ile Thr His  Gly Arg Val 
    1145                 1150                 1155             


Ser Ala  Lys His Asn Asp Gly  Asn Leu Lys Asp Arg  Ser Asp Asp 
    1160                 1165                 1170             


Asp Gln  Arg Leu Ala Glu Lys  Ile Asp Thr Val Arg  Lys Glu Leu 
    1175                 1180                 1185             


Ser Glu  Ser Lys Leu Lys Asp  Tyr Ser Thr Tyr Ala  Arg Gly Val 
    1190                 1195                 1200             


Ile Ser  Asn Ser Leu Lys Asn  Leu Ser Arg Gln Gly  Lys Ser Lys 
    1205                 1210                 1215             


Cys Ser  Val Pro Arg Ser Trp  Leu Glu Lys Val Leu  Phe Asp Leu 
    1220                 1225                 1230             


Lys Val  Pro Thr Lys Asp Glu  Glu Val Leu Ile Asn  Ile Arg Asn 
    1235                 1240                 1245             


Ser Leu  Lys Ala Arg Ser Glu  Phe Val Arg Asn Asn  Asp Lys Leu 
    1250                 1255                 1260             


Leu Ile  Arg Ser Lys Glu Glu  Leu Lys Lys Cys Phe  Asp Val Gln 
    1265                 1270                 1275             


Ser Phe  Lys Leu Lys Lys Asn  Lys Gln Pro Val Pro  Phe Gln Val 
    1280                 1285                 1290             


Asp Cys  Ile Leu Phe Lys Glu  Val Ala Ala Glu Cys  Met Lys Arg 
    1295                 1300                 1305             


Tyr Ile  Gly Thr Pro Tyr Glu  Gly Ile Val Asp Thr  Leu Val Ser 
    1310                 1315                 1320             


Leu Ile  Asn Val Leu Thr Arg  Phe Thr Trp Phe Gln  Glu Val Val 
    1325                 1330                 1335             


Leu Tyr  Gly Lys Ile Cys Glu  Thr Phe Leu Arg Cys  Cys Thr Glu 
    1340                 1345                 1350             


Phe Asn  Arg Ser Gly Val Lys  Leu Val Lys Ile Arg  His Cys Asn 
    1355                 1360                 1365             


Ile Asn  Leu Ser Val Lys Leu  Pro Ser Asn Lys Lys  Glu Asn Met 
    1370                 1375                 1380             


Leu Cys  Cys Leu Tyr Ser Gly  Asn Met Glu Leu Leu  Gln Gly Pro 
    1385                 1390                 1395             


Phe Tyr  Leu Asn Arg Arg Gln  Ala Val Leu Gly Ser  Ser Tyr Leu 
    1400                 1405                 1410             


Tyr Ile  Val Ile Thr Leu Tyr  Ile Gln Val Leu Gln  Gln Tyr Arg 
    1415                 1420                 1425             


Cys Leu  Glu Val Ile Asn Ser  Val Ser Glu Lys Thr  Leu Gln Asp 
    1430                 1435                 1440             


Ile Glu  Asn His Ser Met Thr  Leu Leu Glu Asp Ser  Phe Arg Glu 
    1445                 1450                 1455             


Ile Thr  Phe Ala Leu Glu Gly  Arg Phe Glu Glu Ser  Tyr Lys Ile 
    1460                 1465                 1470             


Arg Thr  Ser Arg Cys Arg Ala  Ser Gly Asn Phe Leu  Asn Arg Ser 
    1475                 1480                 1485             


Ser Arg  Asp His Phe Ile Ser  Val Val Ser Gly Leu  Asn Leu Val 
    1490                 1495                 1500             


Tyr Gly  Phe Leu Ile Lys Asp  Asn Leu Leu Ala Asn  Ser Gln Gln 
    1505                 1510                 1515             


Gln Asn  Lys Gln Leu Gln Met  Leu Arg Phe Gly Met  Leu Ala Gly 
    1520                 1525                 1530             


Leu Ser  Arg Leu Val Cys Pro  Asn Glu Leu Gly Lys  Lys Phe Ser 
    1535                 1540                 1545             


Thr Ser  Cys Arg Arg Ile Glu  Asp Asn Ile Ala Arg  Leu Tyr Leu 
    1550                 1555                 1560             


Gln Thr  Ser Ile Tyr Cys Ser  Val Arg Asp Val Glu  Asp Asn Val 
    1565                 1570                 1575             


Lys His  Trp Lys Gln Arg Asp  Leu Cys Pro Glu Val  Thr Ile Pro 
    1580                 1585                 1590             


Cys Phe  Thr Val Tyr Gly Thr  Phe Val Asn Ser Asp  Arg Gln Leu 
    1595                 1600                 1605             


Ile Phe  Asp Ile Tyr Asn Val  His Ile Tyr Asn Lys  Glu Met Asp 
    1610                 1615                 1620             


Asn Phe  Asp Glu Gly Cys Ile  Ser Val Leu Glu Glu  Thr Ala Glu 
    1625                 1630                 1635             


Arg His  Met Leu Trp Glu Leu  Asp Leu Met Asn Ser  Leu Cys Ser 
    1640                 1645                 1650             


Asp Glu  Lys Lys Asp Thr Arg  Thr Ala Arg Leu Leu  Leu Gly Cys 
    1655                 1660                 1665             


Pro Asn  Val Arg Lys Ala Ala  Asn Arg Glu Gly Lys  Lys Leu Leu 
    1670                 1675                 1680             


Lys Leu  Asn Ser Asp Thr Ser  Thr Asp Thr Gln Ser  Ile Ala Ser 
    1685                 1690                 1695             


Glu Val  Ser Asp Arg Arg Ser  Tyr Ser Ser Ser Lys  Ser Arg Ile 
    1700                 1705                 1710             


Arg Ser  Ile Phe Gly Arg Tyr  Asn Ser Gln Lys Lys  Pro Phe Glu 
    1715                 1720                 1725             


Leu Arg  Ser Gly Leu Glu Val  Phe Asn Asp Pro Phe  Asn Asp Tyr 
    1730                 1735                 1740             


Gln Gln  Ala Ile Thr Asp Ile  Cys Gln Phe Ser Glu  Tyr Thr Pro 
    1745                 1750                 1755             


Asn Lys  Glu Ser Ile Leu Lys  Asp Cys Leu Gln Ile  Ile Arg Lys 
    1760                 1765                 1770             


Asn Pro  Ser His Thr Met Gly  Ser Phe Glu Leu Ile  Gln Ala Ile 
    1775                 1780                 1785             


Ser Glu  Phe Gly Met Ser Lys  Phe Pro Pro Glu Asn  Ile Asp Lys 
    1790                 1795                 1800             


Ala Arg  Arg Asp Pro Lys Asn  Trp Val Ser Ile Ser  Glu Val Thr 
    1805                 1810                 1815             


Glu Thr  Thr Ser Ile Val Ala  Ser Pro Arg Thr His  Met Met Leu 
    1820                 1825                 1830             


Lys Asp  Cys Phe Lys Ile Ile  Leu Gly Thr Glu Asn  Lys Lys Ile 
    1835                 1840                 1845             


Val Lys  Met Leu Arg Gly Lys  Leu Lys Lys Leu Gly  Ala Ile Ser 
    1850                 1855                 1860             


Thr Asn  Ile Glu Ile Gly Lys  Arg Asp Cys Leu Asp  Leu Leu Ser 
    1865                 1870                 1875             


Thr Val  Asp Gly Leu Thr Asp  Gln Gln Lys Glu Asn  Ile Val Asn 
    1880                 1885                 1890             


Gly Ile  Phe Glu Pro Ser Lys  Leu Ser Phe Tyr His  Trp Lys Glu 
    1895                 1900                 1905             


Leu Val  Lys Lys Asn Ile Asp  Glu Val Leu Leu Thr  Glu Asp Gly 
    1910                 1915                 1920             


Asn Leu  Ile Phe Cys Trp Leu  Lys Thr Ile Ser Ser  Ser Val Lys 
    1925                 1930                 1935             


Gly Ser  Leu Lys Lys Arg Leu  Lys Phe Met Asn Ile  His Ser Pro 
    1940                 1945                 1950             


Glu Leu  Met Pro Glu Asn Cys  Leu Phe Ser Ser Glu  Glu Phe Asn 
    1955                 1960                 1965             


Glu Leu  Ile Lys Leu Lys Lys  Leu Leu Leu Asn Glu  Gln Gln Asp 
    1970                 1975                 1980             


Glu Gln  Glu Leu Lys Gln Asp  Leu Leu Ile Ser Ser  Trp Ile Lys 
    1985                 1990                 1995             


Cys Ile  Thr Ala Cys Lys Asp  Phe Ala Ser Ile Asn  Asp Lys Ile 
    2000                 2005                 2010             


Gln Lys  Phe Ile Tyr His Leu  Ser Glu Glu Leu Tyr  Asp Ile Arg 
    2015                 2020                 2025             


Leu Gln  His Leu Glu Leu Ser  Lys Leu Lys Gln Glu  His Pro Ser 
    2030                 2035                 2040             


Val Ser  Phe Thr Lys Glu Glu  Val Leu Ile Lys Arg  Leu Glu Lys 
    2045                 2050                 2055             


Asn Phe  Leu Lys Gln His Asn  Leu Glu Ile Met Glu  Thr Val Asn 
    2060                 2065                 2070             


Leu Val  Phe Phe Ala Ala Leu  Ser Ala Pro Trp Cys  Leu His Tyr 
    2075                 2080                 2085             


Lys Ala  Leu Glu Ser Tyr Leu  Val Arg His Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Cys Gly  Ser Lys Glu Asp Cys  Lys Leu Thr Leu Leu  Asp Leu Ser 
    2105                 2110                 2115             


Val Ser  Lys Leu Leu Val Cys  Leu Tyr Gln Lys Asp  Asp Glu Glu 
    2120                 2125                 2130             


Leu Ile  Asn Ser Ser Ser Leu  Lys Leu Gly Phe Leu  Val Lys Tyr 
    2135                 2140                 2145             


Val Val  Thr Leu Phe Thr Ser  Asn Gly Glu Pro Phe  Ser Leu Ser 
    2150                 2155                 2160             


Leu Asn  Asp Gly Gly Leu Asp  Leu Asp Leu His Lys  Thr Thr Asp 
    2165                 2170                 2175             


Glu Lys  Leu Leu His Gln Thr  Lys Ile Val Phe Ala  Lys Ile Gly 
    2180                 2185                 2190             


Leu Ser  Gly Asn Ser Tyr Asp  Phe Ile Trp Thr Thr  Gln Met Ile 
    2195                 2200                 2205             


Ala Asn  Ser Asn Phe Asn Val  Cys Lys Arg Leu Thr  Gly Arg Ser 
    2210                 2215                 2220             


Thr Gly  Glu Arg Leu Pro Arg  Ser Val Arg Ser Lys  Val Ile Tyr 
    2225                 2230                 2235             


Glu Met  Val Lys Leu Val Gly  Glu Thr Gly Met Ala  Ile Leu Gln 
    2240                 2245                 2250             


Gln Leu  Ala Phe Ala Gln Ala  Leu Asn Tyr Glu His  Arg Phe Tyr 
    2255                 2260                 2265             


Ala Val  Leu Ala Pro Lys Ala  Gln Leu Gly Gly Ala  Arg Asp Leu 
    2270                 2275                 2280             


Leu Val  Gln Glu Thr Gly Thr  Lys Val Met His Ala  Thr Thr Glu 
    2285                 2290                 2295             


Met Phe  Ser Arg Asn Leu Leu  Lys Thr Thr Ser Asp  Asp Gly Leu 
    2300                 2305                 2310             


Thr Asn  Pro His Leu Lys Glu  Thr Ile Leu Asn Val  Gly Leu Asp 
    2315                 2320                 2325             


Cys Leu  Ala Asn Met Arg Asn  Leu Asp Gly Lys Pro  Ile Ser Glu 
    2330                 2335                 2340             


Gly Ser  Asn Leu Val Asn Phe  Tyr Lys Val Ile Cys  Ile Ser Gly 
    2345                 2350                 2355             


Asp Asn  Thr Lys Trp Gly Pro  Ile His Cys Cys Ser  Phe Phe Ser 
    2360                 2365                 2370             


Gly Met  Met Gln Gln Val Leu  Lys Asn Val Pro Asp  Trp Cys Ser 
    2375                 2380                 2385             


Phe Tyr  Lys Leu Thr Phe Ile  Lys Asn Leu Cys Arg  Gln Val Glu 
    2390                 2395                 2400             


Ile Pro  Ala Gly Ser Ile Lys  Lys Ile Leu Asn Val  Leu Arg Tyr 
    2405                 2410                 2415             


Arg Leu  Cys Ser Lys Gly Gly  Val Glu Gln His Ser  Glu Glu Asp 
    2420                 2425                 2430             


Leu Arg  Arg Leu Leu Thr Asp  Asn Leu Asp Ser Trp  Asp Gly Asn 
    2435                 2440                 2445             


Asp Thr  Val Lys Phe Leu Val  Thr Thr Tyr Ile Ser  Lys Gly Leu 
    2450                 2455                 2460             


Met Ala  Leu Asn Ser Tyr Asn  His Met Gly Gln Gly  Ile His His 
    2465                 2470                 2475             


Ala Thr  Ser Ser Val Leu Thr  Ser Leu Ala Ala Val  Leu Phe Glu 
    2480                 2485                 2490             


Glu Leu  Ala Ile Phe Tyr Leu  Lys Arg Ser Leu Pro  Gln Thr Thr 
    2495                 2500                 2505             


Val His  Val Glu His Ala Gly  Ser Ser Asp Asp Tyr  Ala Lys Cys 
    2510                 2515                 2520             


Ile Val  Val Thr Gly Ile Leu  Ser Lys Glu Leu Tyr  Ser Gln Tyr 
    2525                 2530                 2535             


Asp Glu  Thr Phe Trp Lys His  Ala Cys Arg Leu Lys  Asn Phe Thr 
    2540                 2545                 2550             


Ala Ala  Val Gln Arg Cys Cys  Gln Met Lys Asp Ser  Ala Lys Thr 
    2555                 2560                 2565             


Leu Val  Ser Asp Cys Phe Leu  Glu Phe Tyr Ser Glu  Phe Met Met 
    2570                 2575                 2580             


Gly Tyr  Arg Val Thr Pro Ala  Val Ile Lys Phe Met  Phe Thr Gly 
    2585                 2590                 2595             


Leu Ile  Asn Ser Ser Val Thr  Ser Pro Gln Ser Leu  Met Gln Ala 
    2600                 2605                 2610             


Cys Gln  Val Ser Ser Gln Gln  Ala Met Tyr Asn Ser  Val Pro Leu 
    2615                 2620                 2625             


Val Thr  Asn Thr Ala Phe Thr  Leu Leu Arg Gln Gln  Ile Phe Phe 
    2630                 2635                 2640             


Asn His  Val Glu Asp Phe Ile  Arg Arg Tyr Gly Ile  Leu Thr Leu 
    2645                 2650                 2655             


Gly Thr  Leu Ser Pro Phe Gly  Arg Leu Phe Val Pro  Thr Tyr Ser 
    2660                 2665                 2670             


Gly Leu  Val Ser Ser Ala Val  Ala Leu Glu Asp Ala  Glu Val Ile 
    2675                 2680                 2685             


Ala Arg  Ala Ala Gln Thr Leu  Gln Met Asn Ser Val  Ser Ile Gln 
    2690                 2695                 2700             


Ser Ser  Ser Leu Thr Thr Leu  Asp Ser Leu Gly Arg  Ser Arg Thr 
    2705                 2710                 2715             


Ser Ser  Thr Ala Glu Asp Ser  Ser Ser Val Ser Asp  Thr Thr Ala 
    2720                 2725                 2730             


Ala Ser  His Asp Ser Gly Ser  Ser Ser Ser Ser Phe  Ser Phe Glu 
    2735                 2740                 2745             


Leu Asn  Arg Pro Leu Ser Glu  Thr Glu Leu Gln Phe  Ile Lys Ala 
    2750                 2755                 2760             


Leu Ser  Ser Leu Lys Ser Thr  Gln Ala Cys Glu Val  Ile Gln Asn 
    2765                 2770                 2775             


Arg Ile  Thr Gly Leu Tyr Cys  Asn Ser Asn Glu Gly  Pro Leu Asp 
    2780                 2785                 2790             


Arg His  Asn Val Ile Tyr Ser  Ser Arg Met Ala Asp  Ser Cys Asp 
    2795                 2800                 2805             


Trp Leu  Lys Asp Gly Lys Arg  Arg Gly Asn Leu Glu  Leu Ala Asn 
    2810                 2815                 2820             


Arg Ile  Gln Ser Val Leu Cys  Ile Leu Ile Ala Gly  Tyr Tyr Arg 
    2825                 2830                 2835             


Ser Phe  Gly Gly Glu Gly Thr  Glu Lys Gln Val Lys  Ala Ser Leu 
    2840                 2845                 2850             


Asn Arg  Asp Asp Asn Lys Ile  Ile Glu Asp Pro Met  Ile Gln Leu 
    2855                 2860                 2865             


Ile Pro  Glu Lys Leu Arg Arg  Glu Leu Glu Arg Leu  Gly Val Ser 
    2870                 2875                 2880             


Arg Met  Glu Val Asp Glu Leu  Met Pro Ser Ile Ser  Pro Asp Asp 
    2885                 2890                 2895             


Thr Leu  Ala Gln Leu Val Ala  Lys Lys Leu Ile Ser  Leu Asn Val 
    2900                 2905                 2910             


Ser Thr  Glu Glu Tyr Ser Ala  Glu Val Ser Arg Leu  Lys Gln Thr 
    2915                 2920                 2925             


Leu Thr  Ala Arg Asn Val Leu  His Gly Leu Ala Gly  Gly Ile Lys 
    2930                 2935                 2940             


Glu Leu  Ser Leu Pro Ile Tyr  Thr Ile Phe Met Lys  Ser Tyr Phe 
    2945                 2950                 2955             


Phe Lys  Asp Asn Val Phe Leu  Ser Leu Thr Asp Arg  Trp Ser Thr 
    2960                 2965                 2970             


Lys His  Ser Thr Asn Tyr Arg  Asp Ser Cys Gly Lys  Gln Leu Lys 
    2975                 2980                 2985             


Gly Arg  Ile Ile Thr Lys Tyr  Thr His Trp Leu Asp  Thr Phe Leu 
    2990                 2995                 3000             


Gly Cys  Ser Val Ser Ile Asn  Arg His Thr Thr Val  Lys Glu Pro 
    3005                 3010                 3015             


Ser Leu  Phe Asn Pro Asn Ile  Arg Cys Val Asn Leu  Ile Thr Phe 
    3020                 3025                 3030             


Glu Asp  Gly Leu Arg Glu Leu  Ser Val Ile Gln Ser  His Leu Lys 
    3035                 3040                 3045             


Val Phe  Glu Asn Glu Phe Thr  Asn Leu Asn Leu Gln  Phe Ser Asp 
    3050                 3055                 3060             


Pro Asn  Arg Gln Lys Leu Arg  Ile Val Glu Ser Arg  Pro Ala Glu 
    3065                 3070                 3075             


Ser Glu  Leu Glu Ala Asn Arg  Ala Val Ile Val Lys  Thr Lys Leu 
    3080                 3085                 3090             


Phe Ser  Ala Thr Glu Gln Val  Arg Leu Ser Asn Asn  Pro Ala Val 
    3095                 3100                 3105             


Val Met  Gly Tyr Leu Leu Asp  Glu Ser Ala Ile Ser  Glu Val Lys 
    3110                 3115                 3120             


Pro Thr  Lys Val Asp Phe Ser  Asn Leu Leu Lys Asp  Arg Phe Lys 
    3125                 3130                 3135             


Ile Met  Gln Phe Phe Pro Ser  Val Phe Thr Leu Ile  Lys Met Leu 
    3140                 3145                 3150             


Thr Asp  Glu Ser Ser Asp Ser  Glu Lys Ser Gly Leu  Ser Pro Asp 
    3155                 3160                 3165             


Leu Gln  Gln Val Ala Arg Tyr  Ser Asn His Leu Thr  Leu Leu Ser 
    3170                 3175                 3180             


Arg Met  Ile Gln Gln Ala Lys  Pro Thr Val Thr Val  Phe Tyr Met 
    3185                 3190                 3195             


Leu Lys  Gly Asn Leu Met Asn  Thr Glu Pro Thr Val  Ala Glu Leu 
    3200                 3205                 3210             


Val Ser  Tyr Gly Ile Lys Glu  Gly Arg Phe Phe Arg  Leu Ser Asp 
    3215                 3220                 3225             


Thr Gly  Val Asp Ala Ser Thr  Tyr Ser Val Lys Tyr  Trp Lys Ile 
    3230                 3235                 3240             


Leu His  Cys Ile Ser Ala Ile  Gly Cys Leu Pro Leu  Ser Gln Ala 
    3245                 3250                 3255             


Asp Lys  Ser Ser Leu Leu Met  Ser Phe Leu Asn Trp  Arg Val Asn 
    3260                 3265                 3270             


Met Asp  Ile Arg Thr Ser Asp  Cys Pro Leu Ser Ser  His Glu Ala 
    3275                 3280                 3285             


Ser Ile  Leu Ser Glu Phe Asp  Gly Gln Val Ile Ala  Asn Ile Leu 
    3290                 3295                 3300             


Ala Ser  Glu Leu Ser Ser Val  Lys Arg Asp Ser Glu  Arg Glu Gly 
    3305                 3310                 3315             


Leu Thr  Asp Leu Leu Asp Tyr  Leu Asn Ser Pro Thr  Glu Leu Leu 
    3320                 3325                 3330             


Lys Lys  Lys Pro Tyr Leu Gly  Thr Thr Cys Lys Phe  Asn Thr Trp 
    3335                 3340                 3345             


Gly Asp  Ser Asn Arg Ser Gly  Lys Phe Thr Tyr Ser  Ser Arg Ser 
    3350                 3355                 3360             


Gly Glu  Ser Ile Gly Ile Phe  Ile Ala Gly Lys Leu  His Ile His 
    3365                 3370                 3375             


Leu Ser  Ser Glu Ser Val Ala  Leu Leu Cys Glu Thr  Glu Arg Gln 
    3380                 3385                 3390             


Val Leu  Ser Trp Met Ser Lys  Arg Arg Thr Glu Val  Ile Thr Lys 
    3395                 3400                 3405             


Glu Gln  His Gln Leu Phe Leu  Ser Leu Leu Pro Gln  Ser His Glu 
    3410                 3415                 3420             


Cys Leu  Gln Lys His Lys Asp  Gly Ser Ala Leu Ser  Val Ile Pro 
    3425                 3430                 3435             


Asp Ser  Ser Asn Pro Arg Leu  Leu Lys Phe Val Pro  Leu Lys Lys 
    3440                 3445                 3450             


Gly Leu  Ala Val Val Lys Ile  Lys Lys Gln Ile Leu  Thr Val Lys 
    3455                 3460                 3465             


Lys Gln  Val Val Phe Asp Ala  Glu Ser Glu Pro Arg  Leu Gln Trp 
    3470                 3475                 3480             


Gly His  Gly Cys Leu Ser Ile  Val Tyr Asp Glu Thr  Asp Thr Gln 
    3485                 3490                 3495             


Thr Thr  Tyr His Glu Asn Leu  Leu Lys Val Lys His  Leu Val Asp 
    3500                 3505                 3510             


Cys Ser  Thr Asp Arg Lys Lys  Leu Leu Pro Gln Ser  Val Phe Ser 
    3515                 3520                 3525             


Asp Ser  Lys Val Val Leu Ser  Arg Ile Lys Phe Lys  Thr Glu Leu 
    3530                 3535                 3540             


Leu Leu  Asn Ser Leu Thr Leu  Leu His Cys Phe Leu  Lys His Ala 
    3545                 3550                 3555             


Pro Ser  Asp Ala Ile Met Glu  Val Glu Ser Lys Ser  Ser Leu Leu 
    3560                 3565                 3570             


His Lys  Tyr Leu Lys Ser Gly  Gly Val Arg Gln Arg  Asn Thr Glu 
    3575                 3580                 3585             


Val Leu  Phe Arg Glu Lys Leu  Asn Lys Val Val Ile  Lys Asp Asn 
    3590                 3595                 3600             


Leu Glu  Gln Gly Val Glu Glu  Glu Ile Glu Phe Cys  Asn Asn Leu 
    3605                 3610                 3615             


Thr Lys  Thr Val Ser Glu Asn  Pro Leu Pro Leu Ser  Cys Trp Ser 
    3620                 3625                 3630             


Glu Val  Gln Asn Tyr Ile Glu  Asp Ile Gly Phe Asn  Asn Val Leu 
    3635                 3640                 3645             


Val Asn  Ile Asp Arg Asn Thr  Val Lys Ser Glu Leu  Leu Trp Lys 
    3650                 3655                 3660             


Phe Thr  Leu Asp Thr Asn Val  Ser Thr Thr Ser Thr  Ile Lys Asp 
    3665                 3670                 3675             


Val Arg  Thr Leu Val Ser Tyr  Val Ser Thr Glu Thr  Ile Pro Lys 
    3680                 3685                 3690             


Phe Leu  Leu Ala Phe Leu Leu  Tyr Glu Glu Val Leu  Met Asn Leu 
    3695                 3700                 3705             


Ile Asn  Gln Cys Lys Ala Val  Lys Glu Leu Ile Asn  Ser Thr Gly 
    3710                 3715                 3720             


Leu Ser  Asp Leu Glu Leu Glu  Ser Leu Leu Thr Leu  Cys Ala Phe 
    3725                 3730                 3735             


Tyr Phe  Gln Ser Glu Cys Ser  Lys Arg Asp Gly Pro  Arg Cys Ser 
    3740                 3745                 3750             


Phe Ala  Ala Leu Leu Ser Leu  Ile His Glu Asp Trp  Gln Arg Ile 
    3755                 3760                 3765             


Gly Lys  Asn Ile Leu Val Arg  Ala Asn Asn Glu Leu  Gly Asp Val 
    3770                 3775                 3780             


Ser Leu  Lys Val Asn Ile Val  Leu Val Pro Leu Lys  Asp Met Ser 
    3785                 3790                 3795             


Lys Pro  Lys Ser Glu Arg Val  Val Met Ala Arg Arg  Ser Leu Asn 
    3800                 3805                 3810             


His Ala  Leu Ser Leu Met Phe  Leu Asp Glu Met Ser  Leu Pro Glu 
    3815                 3820                 3825             


Leu Lys  Ser Leu Ser Val Asn  Cys Lys Met Gly Asn  Phe Glu Gly 
    3830                 3835                 3840             


Gln Glu  Cys Phe Glu Phe Thr  Ile Leu Lys Asp Asn  Ser Ala Arg 
    3845                 3850                 3855             


Leu Asp  Tyr Asn Lys Leu Ile  Asp His Cys Val Asp  Met Glu Lys 
    3860                 3865                 3870             


Lys Arg  Glu Ala Val Arg Ala  Val Glu Asp Leu Ile  Leu Met Leu 
    3875                 3880                 3885             


Thr Gly  Arg Ala Val Lys Pro  Ser Ala Val Thr Gln  Phe Val His 
    3890                 3895                 3900             


Gly Asp  Glu Gln Cys Gln Glu  Gln Ile Ser Leu Asp  Asp Leu Met 
    3905                 3910                 3915             


Ala Asn  Asp Thr Val Thr Asp  Phe Pro Asp Arg Glu  Ala Glu Ala 
    3920                 3925                 3930             


Leu Lys  Thr Gly Asn Leu Gly  Phe Asn Trp Asp Ser  Asp 
    3935                 3940                 3945     


<210>  9
<211>  1687
<212>  PRT
<213>  Crimean-Congo hemorrhagic fever virus

<400>  9

Met Pro Val Asn Thr Met His Thr Leu Leu Val Tyr Ala Val Phe Cys 
1               5                   10                  15      


Leu Gln Leu Trp Ser Pro Gly Gly Thr Arg Gly Leu Ser Asn Glu Thr 
            20                  25                  30          


Gln His Asn Glu Thr Gly Ile Thr Arg Ala Pro Glu Gly Ser Gln Gly 
        35                  40                  45              


Pro Ser Leu Pro Val Ser Thr Ala Ser Pro Ile Met Ser Asp Pro Ser 
    50                  55                  60                  


Ile Thr Thr Leu Ser Ala Ser Thr Ser Gly Leu Glu Gly Ser Gly Asp 
65                  70                  75                  80  


Thr Thr Pro Pro Ala Ile Thr Gln Gly Pro Thr Leu Pro Glu Thr Thr 
                85                  90                  95      


Pro Glu Pro Ser Thr Thr Thr Gly Thr Asn Ala Phe Ser Thr Ala Ile 
            100                 105                 110         


Ala Asn Val Ser Thr Gln Thr Val Lys Asp Thr Pro Thr Pro Thr Val 
        115                 120                 125             


Gln Thr Ser Pro Pro Ser Thr Pro Asp Ala Ser Thr Ile Pro Gln Gly 
    130                 135                 140                 


Thr His His Thr Ala Arg Gly Leu Leu Ser Val Thr Val Thr Lys Pro 
145                 150                 155                 160 


Glu Glu Val Pro Thr Pro Thr Gly Pro Glu Gln Ala Ser Ile Glu Thr 
                165                 170                 175     


Asn Ser Ser Arg Leu Ala Thr Ser Lys Thr Pro Ser Pro Ser Pro Thr 
            180                 185                 190         


Ala Gln Val Thr Thr Glu Asn Ser Asn Pro Asn Thr Ser Arg Gln Leu 
        195                 200                 205             


Val Leu Ser Thr Gln Pro Ala Thr Ser Ser Pro Val Thr Ser Pro Ala 
    210                 215                 220                 


Gln Leu Asn Phe Val Gln Ser Ala Thr Thr Ile Ala Val Gln Asp Ala 
225                 230                 235                 240 


His Pro Ser Pro Thr Asn Arg Ser Lys Arg Asn Leu Glu Met Glu Val 
                245                 250                 255     


Ile Leu Thr Leu Ser Gln Gly Leu Arg Lys Tyr Tyr Gly Arg Ile Leu 
            260                 265                 270         


Lys Leu Leu Asp Leu Thr Leu Glu Glu Asp Thr Glu Gly Leu Leu Glu 
        275                 280                 285             


Trp Cys Lys Arg Asn Leu Gly Leu Thr Cys Asp Asp Asn Phe Phe Gln 
    290                 295                 300                 


Lys Arg Ile Glu Glu Phe Phe Leu Thr Gly Glu Gly His Phe Asn Glu 
305                 310                 315                 320 


Val Leu Gln Phe Lys Thr Pro Ser Thr Leu Ser Pro Thr Glu Ser Ala 
                325                 330                 335     


Ser Val Gly Leu Pro Thr Val Glu Pro Phe Lys Ser Tyr Phe Ala Lys 
            340                 345                 350         


Gly Phe Leu Ser Ile Asp Ser Gly Tyr Phe Ser Ala Lys Cys Tyr Pro 
        355                 360                 365             


Arg Ala Ser Asn Ser Gly Leu Gln Leu Ile Asn Val Thr Gln His Ser 
    370                 375                 380                 


Ala Arg Ile Ala Asp Thr Pro Gly Pro Lys Ile Thr Asn Leu Lys Thr 
385                 390                 395                 400 


Ile Asn Cys Ile Asn Leu Lys Ala Leu Val Phe Lys Glu His Arg Glu 
                405                 410                 415     


Ile Glu Ile Asn Val Leu Leu Pro Gln Val Ala Val Asn Leu Ser Asn 
            420                 425                 430         


Cys His Val His Ile Lys Ser His Val Cys Asp Tyr Ser Leu Asp Ile 
        435                 440                 445             


Asp Gly Thr Val Arg Leu Pro Arg Ile His His Glu Gly Thr Phe Ile 
    450                 455                 460                 


Pro Gly Thr Tyr Lys Ile Val Ile Asp Lys Lys Asn Lys Gln Asn Asp 
465                 470                 475                 480 


Arg Cys Asn Leu Val Thr Asn Cys Val Ile Lys Gly Arg Glu Val Arg 
                485                 490                 495     


Lys Gly Gln Ser Val Leu Arg Gln Tyr Arg Thr Glu Ile Arg Ile Gly 
            500                 505                 510         


Lys Ala Ser Ser Gly Ser Arg Arg Leu Leu Ser Glu Glu Ser Gly Glu 
        515                 520                 525             


Asp Cys Ile Ser Arg Thr Gln Leu Leu Arg Thr Glu Thr Ala Glu Ile 
    530                 535                 540                 


His Gly Asp Asn Tyr Gly Gly Pro Gly Asp Lys Ile Thr Ile Cys Asn 
545                 550                 555                 560 


Gly Ser Thr Ile Val Asp Gln Arg Leu Gly Ser Glu Leu Gly Cys Tyr 
                565                 570                 575     


Thr Ile Asn Arg Val Lys Ser Phe Lys Leu Cys Glu Asn Ser Ala Thr 
            580                 585                 590         


Gly Lys Ser Cys Glu Ile Asp Asn Thr Pro Val Lys Cys Lys Gln Gly 
        595                 600                 605             


Phe Cys Leu Lys Ile Thr Gln Glu Gly Arg Gly His Val Lys Leu Ser 
    610                 615                 620                 


Arg Asp Ser Glu Val Val Leu Asp Ala Cys Asp Ser Ser Cys Glu Ile 
625                 630                 635                 640 


Met Ile Pro Lys Gly Thr Gly Asp Ile Leu Val Asp Cys Ser Gly Gly 
                645                 650                 655     


Gln Gln His Phe Leu Lys Asp Asn Leu Ile Asp Leu Gly Cys Pro Asn 
            660                 665                 670         


Ile Pro Leu Leu Gly Lys Met Ala Ile Tyr Ile Cys Arg Met Ser Asn 
        675                 680                 685             


His Pro Lys Thr Thr Met Ala Phe Leu Phe Trp Phe Ser Phe Gly Tyr 
    690                 695                 700                 


Val Ile Thr Cys Ile Leu Cys Lys Val Ile Phe Tyr Leu Leu Ile Val 
705                 710                 715                 720 


Val Gly Thr Leu Gly Lys Lys Phe Lys Gln Tyr Arg Glu Leu Lys Pro 
                725                 730                 735     


Gln Thr Cys Thr Ile Cys Glu Thr Thr Pro Val Asn Ala Ile Asp Ala 
            740                 745                 750         


Glu Met His Asp Leu Asn Cys Ser Tyr Asn Ile Cys Pro Tyr Cys Ala 
        755                 760                 765             


Ser Arg Leu Thr Ser Asp Gly Leu Ala Arg His Val Met Gln Cys Pro 
    770                 775                 780                 


Lys Arg Lys Glu Lys Ile Glu Glu Thr Glu Leu Tyr Leu Asn Leu Glu 
785                 790                 795                 800 


Arg Ile Pro Trp Val Val Arg Lys Leu Leu Gln Val Ser Glu Ser Thr 
                805                 810                 815     


Gly Val Ala Leu Lys Arg Ser Ser Trp Leu Ile Val Leu Leu Val Leu 
            820                 825                 830         


Leu Thr Val Ser Leu Ser Pro Val Gln Ser Ala Pro Ile Gly His Gly 
        835                 840                 845             


Lys Thr Ile Glu Thr Tyr Gln Thr Arg Glu Gly Tyr Thr Ser Ile Cys 
    850                 855                 860                 


Leu Phe Val Leu Gly Ser Ile Leu Phe Ile Val Ser His Leu Met Lys 
865                 870                 875                 880 


Gly Leu Val Asp Ser Val Gly Asn Ser Phe Phe Pro Gly Leu Ser Ile 
                885                 890                 895     


Cys Lys Thr Cys Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile Glu Ser 
            900                 905                 910         


His Lys Cys Tyr Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg His Cys 
        915                 920                 925             


Ser Ala Asp Lys Glu Ile His Lys Leu His Leu Ser Ile Cys Lys Lys 
    930                 935                 940                 


Arg Lys Ala Gly Ser Asn Val Met Leu Ala Val Cys Lys Arg Met Cys 
945                 950                 955                 960 


Phe Arg Ala Thr Met Glu Val Ser Asn Lys Ala Leu Leu Ile Arg Ser 
                965                 970                 975     


Val Ile Asn Thr Thr Phe Val Val Cys Ile Leu Ile Leu Ala Val Cys 
            980                 985                 990         


Val Val Ser Thr Ser Ala Val Glu  Met Glu Ser Leu Pro  Ala Gly Thr 
        995                 1000                 1005             


Trp Glu  Arg Glu Glu Asp Leu  Thr Asn Phe Cys His  Gln Glu Cys 
    1010                 1015                 1020             


Gln Val  Thr Glu Thr Glu Cys  Leu Cys Pro Tyr Glu  Ala Leu Val 
    1025                 1030                 1035             


Leu Arg  Lys Pro Leu Phe Leu  Asp Ser Ile Ala Lys  Gly Met Lys 
    1040                 1045                 1050             


Asn Leu  Leu Asn Ser Thr Ser  Leu Glu Thr Ser Leu  Ser Ile Glu 
    1055                 1060                 1065             


Ala Pro  Trp Gly Ala Ile Asn  Val Gln Ser Thr Phe  Lys Pro Thr 
    1070                 1075                 1080             


Val Ser  Thr Ala Asn Ile Ala  Leu Ser Trp Ser Ser  Val Glu His 
    1085                 1090                 1095             


Arg Gly  Asn Lys Ile Leu Val  Ser Gly Arg Ser Glu  Ser Ile Met 
    1100                 1105                 1110             


Lys Leu  Glu Glu Arg Thr Gly  Ile Ser Trp Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Asp Ala  Ser Glu Ser Lys Leu  Leu Thr Val Ser Val  Met Asp Leu 
    1130                 1135                 1140             


Ser Gln  Met Tyr Ser Pro Val  Phe Glu Tyr Leu Ser  Gly Asp Arg 
    1145                 1150                 1155             


Gln Val  Glu Glu Trp Pro Lys  Ala Thr Cys Thr Gly  Asp Cys Pro 
    1160                 1165                 1170             


Glu Arg  Cys Gly Cys Thr Ser  Ser Thr Cys Leu His  Lys Glu Trp 
    1175                 1180                 1185             


Pro His  Ser Arg Asn Trp Arg  Cys Asn Pro Thr Trp  Cys Trp Gly 
    1190                 1195                 1200             


Val Gly  Thr Gly Cys Thr Cys  Cys Gly Leu Asp Val  Lys Asp Leu 
    1205                 1210                 1215             


Phe Thr  Asp Tyr Met Phe Val  Lys Trp Lys Val Glu  Tyr Ile Lys 
    1220                 1225                 1230             


Thr Glu  Ala Ile Val Cys Val  Glu Leu Thr Ser Gln  Glu Arg Gln 
    1235                 1240                 1245             


Cys Ser  Leu Ile Glu Ala Gly  Thr Arg Phe Asn Leu  Gly Pro Val 
    1250                 1255                 1260             


Thr Ile  Thr Leu Ser Glu Pro  Arg Asn Ile Gln Gln  Lys Leu Pro 
    1265                 1270                 1275             


Pro Glu  Ile Val Thr Leu His  Pro Arg Ile Glu Glu  Gly Phe Phe 
    1280                 1285                 1290             


Asp Leu  Met His Val Gln Lys  Val Leu Ser Ala Ser  Thr Val Cys 
    1295                 1300                 1305             


Lys Leu  Gln Ser Cys Thr His  Gly Val Pro Gly Asp  Leu Gln Val 
    1310                 1315                 1320             


Tyr His  Ile Gly Asn Leu Leu  Lys Gly Asp Lys Val  Asn Gly His 
    1325                 1330                 1335             


Leu Ile  His Lys Val Glu Pro  His Phe Asn Thr Ser  Trp Met Ser 
    1340                 1345                 1350             


Trp Asp  Gly Cys Asp Leu Asp  Tyr Tyr Cys Asn Met  Gly Asp Trp 
    1355                 1360                 1365             


Pro Ser  Cys Thr Tyr Thr Gly  Val Thr Gln His Asn  His Ala Ala 
    1370                 1375                 1380             


Phe Val  Asn Leu Leu Asn Ile  Glu Thr Asp Tyr Thr  Lys Asn Phe 
    1385                 1390                 1395             


His Phe  His Ser Lys Arg Val  Thr Ala His Gly Asp  Thr Pro Gln 
    1400                 1405                 1410             


Leu Asp  Leu Lys Ala Arg Pro  Asn Tyr Gly Ala Gly  Glu Ile Thr 
    1415                 1420                 1425             


Val Leu  Val Glu Val Ala Asp  Met Glu Leu His Thr  Lys Lys Ile 
    1430                 1435                 1440             


Glu Ile  Ser Gly Leu Lys Phe  Ala Ser Leu Thr Cys  Thr Gly Cys 
    1445                 1450                 1455             


Tyr Ala  Cys Ser Ser Gly Ile  Ser Cys Lys Val Arg  Ile His Val 
    1460                 1465                 1470             


Asp Glu  Pro Asp Glu Leu Thr  Val His Val Lys Ser  Glu Asp Pro 
    1475                 1480                 1485             


Asp Ile  Val Ala Ala Ser Ser  Ser Leu Met Ala Arg  Lys Leu Glu 
    1490                 1495                 1500             


Phe Gly  Thr Asp Ser Thr Phe  Lys Ala Phe Ser Ala  Met Pro Lys 
    1505                 1510                 1515             


Thr Ser  Leu Cys Phe Tyr Ile  Val Glu Arg Glu Tyr  Cys Lys Ser 
    1520                 1525                 1530             


Cys Ser  Lys Glu Asp Thr Gln  Lys Cys Val Asn Ala  Lys Leu Glu 
    1535                 1540                 1545             


Arg Pro  Gln Ser Ile Leu Ile  Glu His Lys Gly Thr  Ile Ile Gly 
    1550                 1555                 1560             


Lys Gln  Asn Asp Thr Cys Thr  Ala Lys Ala Ser Cys  Trp Leu Glu 
    1565                 1570                 1575             


Ser Val  Lys Ser Phe Phe Tyr  Gly Leu Lys Asn Met  Leu Ser Gly 
    1580                 1585                 1590             


Ile Phe  Gly Asn Val Phe Ile  Gly Ile Phe Leu Phe  Leu Ala Pro 
    1595                 1600                 1605             


Phe Ile  Leu Leu Ile Leu Phe  Phe Met Phe Gly Trp  Arg Ile Leu 
    1610                 1615                 1620             


Phe Cys  Phe Lys Cys Cys Arg  Arg Thr Arg Gly Leu  Phe Lys Tyr 
    1625                 1630                 1635             


Arg His  Leu Lys Asp Asp Glu  Glu Thr Gly Tyr Arg  Lys Ile Ile 
    1640                 1645                 1650             


Glu Arg  Leu Asn Asn Lys Lys  Gly Lys Asn Lys Leu  Leu Asp Gly 
    1655                 1660                 1665             


Glu Arg  Leu Ala Asp Arg Lys  Ile Ala Glu Leu Phe  Ser Thr Lys 
    1670                 1675                 1680             


Thr His  Ile Gly 
    1685         


<210>  10
<211>  5064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
atgcccgtca atactatgca caccctgctg gtctatgctg tcttctgtct gcagctgtgg       60

agccctgggg gaacacgagg cctgagcaat gagacccagc acaacgaaac aggaatcacc      120

cgggcccccg aggggtccca gggaccttct ctgccagtgt ccacagcatc tccaatcatg      180

agtgacccct caattaccac actgtcagcc agcacttccg gcctggaagg gagcggagat      240

actacccccc ctgccattac acaggggccc actctgcctg agacaactcc cgaaccttcc      300

accacaactg gaaccaatgc ttttagtaca gctatcgcaa acgtctcaac acagactgtg      360

aaggacaccc caacacccac tgtgcagact agcccaccct ccaccccaga tgcctctaca      420

attccccagg gcacccacca tacagctagg gggctgctga gtgtgaccgt cacaaaacca      480

gaggaagtgc ctactccaac cggccccgag caggcttcca tcgaaaccaa tagctccaga      540

ctggcaactt ctaagacccc ctctcctagt ccaacagccc aggtgaccac agagaactca      600

aatccaaaca ctagcaggca gctggtcctg agcacccagc cagctacatc tagtcctgtg      660

accagcccag cacagctgaa cttcgtccag tccgctacta ccatcgcagt gcaggacgca      720

cacccatccc ctactaatcg atctaagcgg aacctggaga tggaagtgat tctgaccctg      780

tcccaggggc tgcgcaaata ctatggacga atcctgaagc tgctggacct gactctggag      840

gaagataccg agggcctgct ggaatggtgt aaacgaaatc tggggctgac ctgcgacgat      900

aacttctttc agaagcggat cgaggagttc ttcctgacag gcgaggggca ctttaacgaa      960

gtgctgcagt tcaagacacc ttctactctg agtccaactg aatcagctag cgtcggactg     1020

ccaaccgtgg agcctttcaa atcatacttt gcaaagggat tcctgtcaat tgacagcggc     1080

tactttagtg caaagtgtta tcccagagcc tccaattctg ggctgcagct gatcaacgtg     1140

acacagcata gcgcaaggat cgccgatact ccaggaccca aaattactaa tctgaagacc     1200

atcaattgca ttaacctgaa agctctggtg ttcaaggagc acagagagat cgaaattaac     1260

gtgctgctgc ctcaggtggc agtcaatctg tccaactgtc acgtccatat taagagccat     1320

gtgtgcgatt actccctgga catcgatggc accgtgagac tgcctagaat ccaccatgag     1380

ggcacattca ttccagggac ttacaagatc gtgatcgaca agaaaaataa gcagaacgat     1440

cgctgtaatc tggtcaccaa ctgcgtgatc aaaggacgag aggtccgaaa gggacagagc     1500

gtgctgcggc agtatagaac agaaatccgg attggaaagg cttcaagcgg cagtcggaga     1560

ctgctgtccg aggaatctgg agaggactgc atttcacgga cccagctgct gagaacagag     1620

actgccgaaa tccacgggga caattacggc gggccaggag ataaaatcac tatttgtaac     1680

ggctctacca ttgtggatca gaggctgggc agtgagctgg ggtgctatac catcaatcgc     1740

gtgaagagct tcaagctgtg tgaaaacagt gccaccggca agtcatgcga gattgacaac     1800

acacctgtga agtgtaaaca ggggttctgc ctgaaaatca cccaggaggg acgcggccac     1860

gtgaagctga gtcgagattc agaggtggtc ctggacgcct gtgattcctc ttgcgaaatc     1920

atgattccaa aagggacagg agacatcctg gtggattgct ccggaggcca gcagcacttc     1980

ctgaaggaca atctgatcga tctgggatgt ccaaacattc ccctgctggg caaaatggcc     2040

atctacattt gccgcatgag caaccatcct aagacaacta tggctttcct gttttggttc     2100

tcctttggct acgtcatcac ttgcattctg tgtaaagtga tcttctacct gctgattgtg     2160

gtcggcaccc tggggaagaa attcaaacag tatcgggaac tgaagcccca gacctgcaca     2220

atctgtgaga ccacacctgt gaatgctatt gacgcagaaa tgcacgatct gaattgttcc     2280

tacaacatct gcccatattg tgccagtcgg ctgacctcag acggcctggc tagacatgtg     2340

atgcagtgcc ccaagaggaa agagaagatt gaggaaacag aactgtacct gaacctggag     2400

cgaatccctt gggtggtccg gaaactgctg caggtcagtg agtcaaccgg ggtggcactg     2460

aagagaagtt catggctgat cgtcctgctg gtgctgctga cagtcagcct gtccccagtg     2520

cagtccgcac ctatcggcca cgggaaaacc attgaaacat accagactag ggagggatat     2580

acctctatct gtctgtttgt cctgggctct atcctgttca ttgtgagtca tctgatgaag     2640

ggactggtgg acagcgtggg caattccttc tttcctgggc tgtccatttg caaaacctgt     2700

agcatcggca gcatcaacgg ctttgagatc gaatcacaca agtgctactg tagcctgttc     2760

tgctgtccat attgcagaca ttgttctgcc gataaagaga tccacaagct gcatctgtca     2820

atttgcaaga aaaggaaagc cgggagcaat gtcatgctgg ctgtgtgtaa gcgaatgtgc     2880

tttcgggcaa caatggaggt gagcaataag gccctgctga tccgctcagt gattaacact     2940

accttcgtgg tctgtatcct gattctggct gtctgcgtgg tctctaccag tgcagtggag     3000

atggaaagcc tgccagcagg cacatgggag agagaggaag acctgactaa cttttgtcac     3060

caggaatgcc aagtgactga gaccgaatgc ctgtgtcctt acgaggcact ggtgctgagg     3120

aagccactgt tcctggattc catcgccaaa ggcatgaaga atctgctgaa ctcaacaagc     3180

ctggaaactt ccctgtctat cgaggctcct tggggggcaa ttaatgtcca gagcaccttt     3240

aagccaaccg tgtccacagc caacatcgct ctgtcttgga gcagcgtcga gcaccgcggc     3300

aacaagatcc tggtgagcgg ccggagcgaa tcaattatga agctggagga aaggactgga     3360

atcagctggg acctgggcgt ggaggatgct agcgaatcca agctgctgac cgtgtccgtc     3420

atggacctgt ctcagatgta cagtcccgtc ttcgagtatc tgtctggaga ccgccaggtg     3480

gaggaatggc ccaaagccac atgtactgga gattgccctg agcggtgcgg ctgtacttct     3540

agtacctgtc tgcacaagga atggccacat agcaggaatt ggcgctgtaa cccaacctgg     3600

tgctggggag tgggcacagg gtgcacttgc tgtggcctgg acgtgaagga cctgttcacc     3660

gactacatgt tcgtcaaatg gaaggtggag tatatcaaga ctgaagcaat tgtgtgtgtc     3720

gagctgacct cccaggaacg gcagtgctct ctgatcgagg ccgggaccag attcaacctg     3780

ggacctgtga ccatcacact gagcgagcca cgcaatattc agcagaagct gcctccagaa     3840

atcgtgacac tgcacccccg aattgaggaa ggcttctttg atctgatgca tgtccagaaa     3900

gtgctgtctg ccagtaccgt gtgtaagctg cagtcctgca cacacggagt ccctggcgac     3960

ctgcaggtgt accatattgg gaatctgctg aaaggagata aggtcaacgg ccacctgatc     4020

cataaggtgg agccacactt taacacctct tggatgagtt gggacggctg tgacctggat     4080

tactattgca atatggggga ttggccctct tgcacttaca ccggagtcac acagcacaac     4140

catgccgctt tcgtgaatct gctgaacatc gagaccgact acacaaagaa cttccacttt     4200

catagcaaga gagtgaccgc tcacggggac acaccccagc tggatctgaa agctaggcct     4260

aactacggag caggcgagat caccgtgctg gtcgaggtgg ccgatatgga actgcataca     4320

aagaaaatcg aaattagtgg actgaagttc gcatcactga catgcactgg gtgttatgcc     4380

tgctcaagcg gaatctcttg caaagtccgc attcacgtgg acgagcccga tgaactgacc     4440

gtccatgtga agagcgagga ccctgatatc gtggcagcct cctctagtct gatggcccgg     4500

aagctggaat ttggcactga cagcaccttc aaagcatttt ccgccatgcc aaagacatct     4560

ctgtgtttct acatcgtgga gcgcgaatat tgtaaatcat gcagcaagga ggacactcag     4620

aaatgcgtga atgccaagct ggaacggccc cagagcatcc tgattgagca caaagggacc     4680

atcattggaa agcagaacga tacctgtaca gccaaggcta gctgctggct ggagtcagtg     4740

aagagcttct tctacggact gaagaatatg ctgtccggga tttttggaaa cgtgttcatc     4800

ggcattttcc tgtttctggc cccctttatc ctgctgattc tgttctttat gttcggctgg     4860

agaatcctgt tctgctttaa atgctgtagg cgcacaagag ggctgtttaa atacaggcac     4920

ctgaaggacg atgaggaaac tggatatagg aagatcattg agcgcctgaa caataagaaa     4980

ggcaaaaaca agctgctgga cggggaaaga ctggccgata ggaaaattgc tgagctgttc     5040

tccactaaga cccatatcgg ctga                                            5064


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
atgaacaggt ggtttgaaga gtt                                               23


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
tggcactggc catctga                                                      17


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  13
tgtccaaatt gggaacactc tcgca                                             25


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
tgatgatgct gccttaggat c                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
tggagactgt taccaacaag a                                                 21


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  16
tgcagcaggt gctcagaggc taca                                              24


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
ggctgagtgt ggagcacc                                                     18


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
aacaggattt aacatacagg acatg                                             25


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  19
tcccttgttg gcaagcagtc tcca                                              24


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
atggagactg ttaccaacaa g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
tgatgatgct gccttaggat c                                                 21


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  22
tgcagcaggt gctcagaggc taca                                              24


