﻿                         序列表

<110>  神州细胞工程有限公司

<120>  人源化抗PD-1抗体及其用途

<130>  FP1180486P

<141>  2018-12-21

<160>  35

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  167
<212>  PRT
<213>  智人(Homo sapiens)

<400>  1
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln 
                165         

<210>  2
<211>  54
<212>  DNA
<213>  小家鼠(Mus musculus)

<400>  2
tctagtggtg gcggtggttc gggcggtggt ggaggtggta gttctagatc ttcc              54

<210>  3
<211>  741
<212>  DNA
<213>  小家鼠(Mus musculus)

<400>  3
gatattgtgc taactcaatc tccagcttct ttggctgtgt ctctagggca gagggccacc        60
atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac       120
cagcagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc       180
ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat       240
cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg       300
acgttcggtg gaggcaccaa gctggaaatc aaatctagtg gtggcggtgg ttcgggcggt       360
ggtggaggtg gtagttctag atcttccgag gtgcaactgg tggaatctgg gggaggctta       420
gtgaagcctg gagggtccct gaaactctcc tgtgcagcct ctggattcac tttcagttcc       480
tatggcatgt cttgggttcg tcagactccg gagaagaggc tggagtgggt cgcgaccatt       540
agtggtggtg gtcgtgacac ctactattca gacagtgtga aggggcggtt caccgtctcc       600
agagacaatg ccaagaacaa cctgttcctg caaatgagca gtctgaggtc tgaagacacg       660
gccttgtatt attgttcacg tcaatatggt acggtctggt tttttaactg gggccagggg       720
actctggtca ctgtctctgc a                                                 741

<210>  4
<211>  354
<212>  DNA
<213>  小家鼠(Mus musculus)

<400>  4
gaggtgcaac tggtggaatc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc        60
tcctgtgcag cctctggatt cactttcagt tcctatggca tgtcttgggt tcgtcagact       120
ccggagaaga ggctggagtg ggtcgcgacc attagtggtg gtggtcgtga cacctactat       180
tcagacagtg tgaaggggcg gttcaccgtc tccagagaca atgccaagaa caacctgttc       240
ctgcaaatga gcagtctgag gtctgaagac acggccttgt attattgttc acgtcaatat       300
ggtacggtct ggttttttaa ctggggccag gggactctgg tcactgtctc tgca             354

<210>  5
<211>  333
<212>  DNA
<213>  小家鼠(Mus musculus)

<400>  5
gatattgtgc taactcaatc tccagcttct ttggctgtgt ctctagggca gagggccacc        60
atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac       120
cagcagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc       180
ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat       240
cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg       300
acgttcggtg gaggcaccaa gctggaaatc aaa                                    333

<210>  6
<211>  972
<212>  DNA
<213>  小家鼠(Mus musculus)

<400>  6
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac        60
tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc       120
tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac       180
ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc       240
acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg       300
gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc       360
cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg       420
gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag       480
gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc       540
agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc       600
aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg       660
aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc       720
agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg       780
aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct       840
tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc       900
acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac       960
tctcctggta aa                                                           972

<210>  7
<211>  321
<212>  DNA
<213>  小家鼠(Mus musculus)

<400>  7
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct        60
ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag       120
tggaagattg atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac       180
agcaaagaca gcacctacag catgagcagc accctcacgt tgaccaagga cgagtatgaa       240
cgacataaca gctatacctg tgaggccact cacaagacat caacttcacc cattgtcaag       300
agcttcaaca ggaatgagtg t                                                 321

<210>  8
<211>  118
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Asn Leu Phe 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Gln Tyr Gly Thr Val Trp Phe Phe Asn Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             

<210>  9
<211>  111
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  9
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  10
<211>  12
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  10
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10          

<210>  11
<211>  11
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  11
Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
1               5                   10      

<210>  12
<211>  9
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  12
Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   

<210>  13
<211>  10
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  13
Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  

<210>  14
<211>  19
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  14
Val Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      
Val Lys Gly 
            

<210>  15
<211>  11
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  15
Ser Arg Gln Tyr Gly Thr Val Trp Phe Phe Asn 
1               5                   10      

<210>  16
<211>  445
<212>  PRT
<213>  智人(Homo sapiens)

<400>  16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Gln Tyr Gly Thr Val Trp Phe Phe Asn Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 

<210>  17
<211>  218
<212>  PRT
<213>  智人(Homo sapiens)

<400>  17
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210>  18
<211>  464
<212>  PRT
<213>  智人(Homo sapiens)

<400>  18
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ser 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      
Asn Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ser Arg Gln Tyr Gly Thr Val Trp Phe Phe Asn Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
225                 230                 235                 240 
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
                245                 250                 255     
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        275                 280                 285             
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            340                 345                 350         
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            420                 425                 430         
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460                 

<210>  19
<211>  237
<212>  PRT
<213>  智人(Homo sapiens)

<400>  19
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              
Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  
Gln Pro Pro Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
65                  70                  75                  80  
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      
Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Phe Cys Gln 
            100                 105                 110         
Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         

<210>  20
<211>  19
<212>  PRT
<213>  智人(Homo sapiens)

<400>  20
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser 
            

<210>  21
<211>  19
<212>  PRT
<213>  智人(Homo sapiens)

<400>  21
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210>  22
<211>  118
<212>  PRT
<213>  智人(Homo sapiens)

<400>  22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Gln Tyr Gly Thr Val Trp Phe Phe Asn Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  23
<211>  111
<212>  PRT
<213>  智人(Homo sapiens)

<400>  23
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210>  24
<211>  327
<212>  PRT
<213>  智人(Homo sapiens)

<400>  24
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210>  25
<211>  107
<212>  PRT
<213>  智人(Homo sapiens)

<400>  25
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  26
<211>  1395
<212>  DNA
<213>  智人(Homo sapiens)

<400>  26
atgggctggt ccctgattct gctgttcctg gtggctgtgg ctaccagggt gctgtctgag        60
gtccaacttg tggagtctgg aggaggactg gtgaagcctg gaggctccct gagactgtcc       120
tgtgctgcct ctggcttcac cttctcctcc tatgggatga gttgggtgag acaggctcct       180
gggaagagat tggagtgggt ggctaccatc tctggaggag gcagggacac ctactactct       240
gactctgtga agggcaggtt cacaatcagc agggacaatg ccaagaacaa cctgtacctc       300
caaatgaact ccctgagggc tgaggacaca gcagtctact actgtagcag acaatatggc       360
acagtgtggt tcttcaactg gggacaaggc accctggtga cagtgtcctc tgctagcacc       420
aagggcccat cggtcttccc gctggcgccc tgctccagga gcacctccga gagcacagcc       480
gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca       540
ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac       600
tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc       660
aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt       720
cccccatgcc caccctgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc       780
cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg       840
gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag       900
gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc       960
agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      1020
tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc      1080
cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc      1140
agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggaaagc      1200
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc      1260
ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc      1320
tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg      1380
tctctgggta aataa                                                       1395

<210>  27
<211>  714
<212>  DNA
<213>  智人(Homo sapiens)

<400>  27
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcattctgag        60
attgtgctga cccagagccc tgccaccctg tccctgagcc ctggagagag ggctaccctg       120
tcctgtaggg catctgagtc tgtggactcc tatggcaact cctttatgca ctggtatcaa       180
cagaagcctg gacaaccacc aagactgctg atttatgctg ccagcaacca gggctctgga       240
gtgcctgcca ggttctctgg ctctggctct ggcacagact tcaccctgac catctcctcc       300
ttggaacctg aggactttgc tatgtacttc tgtcaacaga gcaaggaggt gccatggacc       360
tttggacaag gcaccaaggt ggagattaag cgtacggtgg ctgcaccatc tgtcttcatc       420
ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat       480
aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt       540
aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc       600
accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc       660
catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag             714

<210>  28
<211>  57
<212>  DNA
<213>  智人(Homo sapiens)

<400>  28
atgggctggt ccctgattct gctgttcctg gtggctgtgg ctaccagggt gctgtct           57

<210>  29
<211>  57
<212>  DNA
<213>  智人(Homo sapiens)

<400>  29
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcattct           57

<210>  30
<211>  354
<212>  DNA
<213>  智人(Homo sapiens)

<400>  30
gaggtccaac ttgtggagtc tggaggagga ctggtgaagc ctggaggctc cctgagactg        60
tcctgtgctg cctctggctt caccttctcc tcctatggga tgagttgggt gagacaggct       120
cctgggaaga gattggagtg ggtggctacc atctctggag gaggcaggga cacctactac       180
tctgactctg tgaagggcag gttcacaatc agcagggaca atgccaagaa caacctgtac       240
ctccaaatga actccctgag ggctgaggac acagcagtct actactgtag cagacaatat       300
ggcacagtgt ggttcttcaa ctggggacaa ggcaccctgg tgacagtgtc ctct             354

<210>  31
<211>  333
<212>  DNA
<213>  智人(Homo sapiens)

<400>  31
gagattgtgc tgacccagag ccctgccacc ctgtccctga gccctggaga gagggctacc        60
ctgtcctgta gggcatctga gtctgtggac tcctatggca actcctttat gcactggtat       120
caacagaagc ctggacaacc accaagactg ctgatttatg ctgccagcaa ccagggctct       180
ggagtgcctg ccaggttctc tggctctggc tctggcacag acttcaccct gaccatctcc       240
tccttggaac ctgaggactt tgctatgtac ttctgtcaac agagcaagga ggtgccatgg       300
acctttggac aaggcaccaa ggtggagatt aag                                    333

<210>  32
<211>  984
<212>  DNA
<213>  智人(Homo sapiens)

<400>  32
gctagcacca agggcccatc ggtcttcccg ctggcgccct gctccaggag cacctccgag        60
agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc       240
tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc       300
aaatatggtc ccccatgccc accctgccca gcacctgagt tcctgggggg accatcagtc       360
ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg       420
tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat       480
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac       540
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag       600
tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa       660
gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag       720
aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag       780
tgggaaagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc       840
gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg       900
aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc       960
ctctccctgt ctctgggtaa ataa                                              984

<210>  33
<211>  324
<212>  DNA
<213>  智人(Homo sapiens)

<400>  33
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct        60
ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag       120
tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac       180
agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag       240
aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag       300
agcttcaaca ggggagagtg ttag                                              324

<210>  34
<211>  247
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  34
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser 
            100                 105                 110         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser Arg Ser 
        115                 120                 125             
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly 
    130                 135                 140                 
Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
145                 150                 155                 160 
Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp 
                165                 170                 175     
Val Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ser Asp Ser 
            180                 185                 190         
Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Asn Leu 
        195                 200                 205             
Phe Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr 
    210                 215                 220                 
Cys Ser Arg Gln Tyr Gly Thr Val Trp Phe Phe Asn Trp Gly Gln Gly 
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ala 
                245         

<210>  35
<211>  18
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  35
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser Arg 
1               5                   10                  15      
Ser Ser 
        

