﻿                         SEQUENCE LISTING

<110>  Université de Poitiers
       Bioalternatives
       Institut National de la Santé et de la Recherche Medicale
 
<120>  Protéine de liaison spécifique capable de se lier spécifiquement 
       à l'oncostatine M  humaine (hOSM) et ses utilisations

<130>  WOBV18SATGOSM

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  2
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  2

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Arg Asp Arg Tyr Glu Ala Met Asp Tyr 
1               5                   10  


<210>  4
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Ser Leu Leu Ser Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  5
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  9
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  9
gaggtgcagc tgcaggagtc tggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacataagct acagtggtag cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagagatagg      300

tacgaggcta tggactattg gggtcaagga acctcagtca ccgtctcctc ag              352


<210>  10
<211>  340
<212>  DNA
<213>  Mus musculus

<400>  10
gacattgtga tgacccagac tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta agtagtggta atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tcttcggggc ttccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac                            340


<210>  11
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  11
ggctactcaa tcaccagtga ttatgcc                                           27


<210>  12
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  12
ataagctaca gtggtagcac t                                                 21


<210>  13
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  13
gcaagagata ggtacgaggc tatggactat                                        30


<210>  14
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  14
cagagtctgt taagtagtgg taatcaaaag aactac                                 36


<210>  15
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  15
ggggcttcc                                                                9


<210>  16
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  16
cagaatgatc atagttatcc gctcacg                                           27


<210>  17
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr 
1               5                   10  


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  19

Val Arg Tyr Asp Trp Phe Ala Tyr 
1               5               


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Lys Ser Val Ser Thr Ser Val Tyr Asn Tyr 
1               5                   10  


<210>  21
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  21

Leu Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  22

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  23
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  24
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Val Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  25
gaggtgcagc tgcaggagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat acctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgt ataagaagta aaagtgataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgcgt      300

tacgactggt ttgcttactg gggccaaggg actctggtca ctgtctctgc ag              352


<210>  26
<211>  334
<212>  DNA
<213>  Mus musculus

<400>  26
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctgtct ataattattt acactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaac                                  334


<210>  27
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  27
ggattcacct tcaataccta cgcc                                              24


<210>  28
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  28
ataagaagta aaagtgataa ttatgcaaca                                        30


<210>  29
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  29
gtgcgttacg actggtttgc ttac                                              24


<210>  30
<211>  29
<212>  DNA
<213>  Mus musculus

<400>  30
aaaagtgtca gtacatctgt ctataatta                                         29


<210>  31
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  31
cttgcatcc                                                                9


<210>  32
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  32
cagcacagta gggagcttcc gtggacg                                           27


<210>  33
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  33

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  34
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  34

Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr 
1               5                   10  


<210>  35
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  35

Val Arg Tyr Asp Trp Phe Val Tyr 
1               5               


<210>  36
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  36

Lys Ser Val Ser Ser Ser Val Tyr Asn Tyr 
1               5                   10  


<210>  37
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  37

Leu Ala Ser 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  38

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  39
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  39

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Asp Asp Thr Gly Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Tyr Asp Trp Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  40
<211>  101
<212>  PRT
<213>  Mus musculus

<400>  40

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Val Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr 
            100     


<210>  41
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  41
gaggtgcagc tgcaggagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat acctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtgataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc acaaaacatg      240

ctctatctgc aaatgaacaa cttgaaaact gacgacacag gcatgtatta ctgtgtgcgt      300

tacgactggt ttgtttactg gggccaaggg actctggtca ctgtctctgc ag              352


<210>  42
<211>  303
<212>  DNA
<213>  Mus musculus

<400>  42
gacattgtga tgacacagac tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcatctgtct ataattattt acactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtgg      300

acg                                                                    303


<210>  43
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  43
ggattcacct tcaataccta cgcc                                              24


<210>  44
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  44
ataagaagta aaagtgataa ttatgcaaca                                        30


<210>  45
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  45
gtgcgttacg actggtttgt ttac                                              24


<210>  46
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  46
aaaagtgtca gttcatctgt ctataattat                                        30


<210>  47
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  47
cttgcatcc                                                                9


<210>  48
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  48
cagcacagta gggagcttcc gtggacg                                           27


<210>  49
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  49

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  50
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  50

Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr 
1               5                   10  


<210>  51
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  51

Val Arg Tyr Asp Trp Phe Val Tyr 
1               5               


<210>  52
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  52

Lys Ser Val Ser Ser Ser Val Tyr Asn Tyr 
1               5                   10  


<210>  53
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  53

Leu Ala Ser 
1           


<210>  54
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  54

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  55
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  55

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Tyr Asp Trp Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  56
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  56

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Val Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly 
            100             


<210>  57
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  57
gaggtgcagc tgcaggagtc tggtggagga ttggtacagc ctaaagggtc attgaaactc       60

tcatgtgcgg cctctggatt caccttcaat acctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtgataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatttcca gagatgattc acaaagcatc      240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgcgt      300

tacgactggt ttgtttattg gggccaaggg actctggtca ctgtctctgc ag              352


<210>  58
<211>  309
<212>  DNA
<213>  Mus musculus

<400>  58
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcatctgtct ataattattt acactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga acttccgtgg      300

acgttcggt                                                              309


<210>  59
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  59
ggattcacct tcaataccta cgcc                                              24


<210>  60
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  60
ataagaagta aaagtgataa ttatgcaaca                                        30


<210>  61
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  61
gtgcgttacg actggtttgt ttat                                              24


<210>  62
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  62
aaaagtgtca gttcatctgt ctataattat                                        30


<210>  63
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  63
cttgcatcc                                                                9


<210>  64
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  64
cagcacagta gggaacttcc gtggacg                                           27


<210>  65
<211>  759
<212>  DNA
<213>  Homo sapiens

<400>  65
atgggggtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca       60

agcatggcga gcatggcggc tataggcagc tgctcgaaag agtaccgcgt gctccttggc      120

cagctccaga agcagacaga tctcatgcag gacaccagca gactcctgga cccctatata      180

cgtatccaag gcctggatgt tcctaaactg agagagcact gcagggagcg ccccggggcc      240

ttccccagtg aggagaccct gagggggctg ggcaggcggg gcttcctgca gaccctcaat      300

gccacactgg gctgcgtcct gcacagactg gccgacttag agcagcgcct ccccaaggcc      360

caggatttgg agaggtctgg gctgaacatc gaggacttgg agaagctgca gatggcgagg      420

ccgaacatcc tcgggctcag gaacaacatc tactgcatgg cccagctgct ggacaactca      480

gacacggctg agcccacgaa ggctggccgg ggggcctctc agccgcccac ccccacccct      540

gcctcggatg cttttcagcg caagctggag ggctgcaggt tcctgcatgg ctaccatcgc      600

ttcatgcact cagtggggcg ggtcttcagc aagtgggggg agagcccgaa ccggagccgg      660

agacacagcc cccaccaggc cctgaggaag ggggtgcgca ggaccagacc ctccaggaaa      720

ggcaagagac tcatgaccag gggacagctg ccccggtag                             759


