                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND COMPOSITIONS FOR TREATING CANCERS AND RESISTANT 
       CANCERS

<130>  BIO16063 POUL / MS

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7-antibody (heavy and light chains) with a linker

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Tyr Gly Asp Tyr Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val 
    130                 135                 140                 


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Met Tyr Gly Arg Asn Glu Arg Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Gln Pro Glu Asp Glu Ala Asn Tyr Tyr Cys Ala Gly Trp 
    210                 215                 220                 


Asp Asp Ser Leu Thr Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of H7

<400>  2

Ser Tyr Ala Met His 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of H7

<400>  3

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of H7

<400>  4

Asp Leu Ser Gly Tyr Gly Asp Tyr Pro Asp Tyr 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of H7

<400>  5

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 of H7

<400>  6

Gly Arg Asn Glu Arg Pro Ser 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of H7

<400>  7

Ala Gly Trp Asp Asp Ser Leu Thr Gly Pro Val 
1               5                   10      


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of H7

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Tyr Gly Asp Tyr Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of H7

<400>  9

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr Gly 
        35                  40                  45              


Arg Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Glu Ala Asn Tyr Tyr Cys Ala Gly Trp Asp Asp Ser Leu Thr Gly Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F12-antibody (heavy and light chains) with a linker

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Ala Tyr Asp Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Ala Gly Glu Gly Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Asp Pro Ala 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Leu Pro Gly Thr 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
        195                 200                 205             


Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Trp Asp Asp Ser Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu Gly Ala 
                245 


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of F12

<400>  11

Thr Tyr Thr Met His 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of F12

<400>  12

Asp Ile Ala Tyr Asp Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of F12

<400>  13

Asp Ala Val Ala Gly Glu Gly Tyr Phe Asp Leu 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of F12

<400>  14

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 of F12

<400>  15

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of F12

<400>  16

Ala Ala Trp Asp Asp Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of F12

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Ala Tyr Asp Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Ala Gly Glu Gly Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of F12

<400>  18

Gln Ser Ala Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Ala 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            100                 105                 110 


<210>  19
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C32-antibody (heavy and light chains) with a linker

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Ser Ser Trp Ser His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Tyr Ile Ser Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Glu 
    210                 215                 220                 


Ser Tyr Asn Thr Pro Leu Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of C32

<400>  20

Ser Tyr Ala Met Ser 
1               5   


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of C32

<400>  21

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of C32

<400>  22

Val Ser Ser Ser Trp Ser His Phe Asp Tyr 
1               5                   10  


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of C32

<400>  23

Arg Ala Ser Gln Tyr Ile Ser Asn Trp Leu Ala 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 of C32

<400>  24

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of C32

<400>  25

Gln Glu Ser Tyr Asn Thr Pro Leu Phe Thr 
1               5                   10  


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of C32

<400>  26

Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Val Ser Ser Ser Trp Ser His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  27
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of C32

<400>  27

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Tyr Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Glu Ser Tyr Asn Thr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  28
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2-antibody (heavy and light chains) with a linker

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Phe Ser Ala Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Ala Tyr Asp Gly Asn Gln Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Met Gln Arg Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Asp Pro Ala Val 
    130                 135                 140                 


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Asp Ile 
        195                 200                 205             


Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp 
    210                 215                 220                 


Asp Asp Asn Leu Ser Gly Pro Ile Phe Gly Gly Gly Thr Lys Val Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of F2

<400>  29

Ala Ser Gly Met His 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of F2

<400>  30

Phe Ile Ala Tyr Asp Gly Asn Gln Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of F2

<400>  31

Glu Met Gln Arg Glu Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of F2

<400>  32

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 of F2

<400>  33

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of F2

<400>  34

Ala Thr Trp Asp Asp Asn Leu Ser Gly Pro Ile 
1               5                   10      


<210>  35
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of F2

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Phe Ser Ala Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Ala Tyr Asp Gly Asn Gln Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Met Gln Arg Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of F2

<400>  36

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Asn Leu Ser Gly 
                85                  90                  95      


Pro Ile Phe Gly Gly Gly Thr 
            100             


<210>  37
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H9-antibody (heavy and light chains) with a linker

<400>  37

Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Thr Ser Gly Ser Ser Ile Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Asp Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Asp Tyr Ala Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 
    130                 135                 140                 


Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 
145                 150                 155                 160 


Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser 
        195                 200                 205             


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp 
    210                 215                 220                 


Asp Asn Leu Ser Gly Pro Ile Phe Gly Gly Gly Thr Lys Val Thr Val 
225                 230                 235                 240 


Leu Gly 
        


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of H9

<400>  38

Asp Tyr Tyr Met Ser 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of H9

<400>  39

Tyr Ile Ser Thr Ser Gly Ser Ser Ile Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of H9

<400>  40

Asp Leu His Gly Asp Tyr Ala Phe Asp Ser 
1               5                   10  


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of H9

<400>  41

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 of H9

<400>  42

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of H9

<400>  43

Ala Thr Trp Asp Asp Asn Leu Ser Gly Pro Ile 
1               5                   10      


<210>  44
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of H9

<400>  44

Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Thr Ser Gly Ser Ser Ile Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Asp Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Asp Tyr Ala Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of H9

<400>  45

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Asn Leu Ser Gly Pro 
                85                  90                  95      


Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  46
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G9-antibody (heavy and light chains) with a linker

<400>  46

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile His His Asp Gly Asn Gly Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Gly Tyr Leu Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
    210                 215                 220                 


Ser Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
225                 230                 235                 240 


Gly 
    


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of G9

<400>  47

Asn Tyr Ala Ile Asn 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of G9

<400>  48

Asn Ile His His Asp Gly Asn Gly Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of G9

<400>  49

Asp Gly Tyr Gly Gly Tyr Leu Asp Leu 
1               5                   


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of G9

<400>  50

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 of G9

<400>  51

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of G9

<400>  52

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  53
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of G9

<400>  53

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile His His Asp Gly Asn Gly Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Gly Tyr Leu Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  54
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of G9

<400>  54

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


