                         SEQUENCE LISTING

<110>  sphingotec GmbH
 
<120>  Selenoprotein P in heart failure

<130>  S75273WO

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  381
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(381)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  1

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu 
    50                  55                  60                  


Gln Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly 
65                  70                  75                  80  


Tyr Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser 
                85                  90                  95      


Arg Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro 
            100                 105                 110         


Val Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn 
        115                 120                 125             


Gly Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val 
    130                 135                 140                 


Tyr His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu 
145                 150                 155                 160 


Glu Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser 
                165                 170                 175     


Leu Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala 
            180                 185                 190         


Thr Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu 
        195                 200                 205             


His His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser 
    210                 215                 220                 


Glu Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro 
225                 230                 235                 240 


Pro Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln Gly 
                245                 250                 255     


His Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu 
            260                 265                 270         


Gln Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys 
        275                 280                 285             


Leu Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys 
    290                 295                 300                 


Arg His Leu Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Xaa Gln Cys 
305                 310                 315                 320 


Lys Glu Asn Leu Pro Ser Leu Cys Ser Xaa Gln Gly Leu Arg Ala Glu 
                325                 330                 335     


Glu Asn Ile Thr Glu Ser Cys Gln Xaa Arg Leu Pro Pro Ala Ala Xaa 
            340                 345                 350         


Gln Ile Ser Gln Gln Leu Ile Pro Thr Glu Ala Ser Ala Ser Xaa Arg 
        355                 360                 365             


Xaa Lys Asn Gln Ala Lys Lys Xaa Glu Xaa Pro Ser Asn 
    370                 375                 380     


<210>  2
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(362)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  2

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys Arg His Leu 
        275                 280                 285             


Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Xaa Gln Cys Lys Glu Asn 
    290                 295                 300                 


Leu Pro Ser Leu Cys Ser Xaa Gln Gly Leu Arg Ala Glu Glu Asn Ile 
305                 310                 315                 320 


Thr Glu Ser Cys Gln Xaa Arg Leu Pro Pro Ala Ala Xaa Gln Ile Ser 
                325                 330                 335     


Gln Gln Leu Ile Pro Thr Glu Ala Ser Ala Ser Xaa Arg Xaa Lys Asn 
            340                 345                 350         


Gln Ala Lys Lys Xaa Glu Xaa Pro Ser Asn 
        355                 360         


<210>  3
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(327)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  3

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys Arg His Leu 
        275                 280                 285             


Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Xaa Gln Cys Lys Glu Asn 
    290                 295                 300                 


Leu Pro Ser Leu Cys Ser Xaa Gln Gly Leu Arg Ala Glu Glu Asn Ile 
305                 310                 315                 320 


Thr Glu Ser Cys Gln Xaa Arg 
                325         


<210>  4
<211>  279
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(279)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  4

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg 
        275                 


<210>  5
<211>  280
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(280)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  5

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser 
        275                 280 


<210>  6
<211>  281
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(281)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  6

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa 
        275                 280     


<210>  7
<211>  282
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(282)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  7

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys 
        275                 280         


<210>  8
<211>  283
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(283)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  8

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys 
        275                 280             


<210>  9
<211>  284
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(284)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  9

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His 
        275                 280                 


<210>  10
<211>  285
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(285)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  10

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys 
        275                 280                 285 


<210>  11
<211>  286
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(286)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  11

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys Arg 
        275                 280                 285     


<210>  12
<211>  287
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(287)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  12

Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val 
            20                  25                  30          


Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu Gln Ala Ser 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
    50                  55                  60                  


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
65                  70                  75                  80  


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
                85                  90                  95      


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
            100                 105                 110         


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
        115                 120                 125             


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
    130                 135                 140                 


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
145                 150                 155                 160 


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
                165                 170                 175     


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
            180                 185                 190         


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
        195                 200                 205             


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
    210                 215                 220                 


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
225                 230                 235                 240 


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
                245                 250                 255     


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
            260                 265                 270         


Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys Arg His 
        275                 280                 285         


<210>  13
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(235)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  13

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser Xaa Tyr Leu Cys Ile Leu 
    50                  55                  60                  


Gln Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly 
65                  70                  75                  80  


Tyr Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser 
                85                  90                  95      


Arg Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro 
            100                 105                 110         


Val Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn 
        115                 120                 125             


Gly Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val 
    130                 135                 140                 


Tyr His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu 
145                 150                 155                 160 


Glu Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser 
                165                 170                 175     


Leu Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala 
            180                 185                 190         


Thr Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu 
        195                 200                 205             


His His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser 
    210                 215                 220                 


Glu Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro 
225                 230                 235 


<210>  14
<211>  103
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(103)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  14

Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr Asp Ser Glu 
1               5                   10                  15      


Leu Ala Pro Arg Ser Xaa Cys Cys His Cys Arg His Leu Ile Phe Glu 
            20                  25                  30          


Lys Thr Gly Ser Ala Ile Thr Xaa Gln Cys Lys Glu Asn Leu Pro Ser 
        35                  40                  45              


Leu Cys Ser Xaa Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr Glu Ser 
    50                  55                  60                  


Cys Gln Xaa Arg Leu Pro Pro Ala Ala Xaa Gln Ile Ser Gln Gln Leu 
65                  70                  75                  80  


Ile Pro Thr Glu Ala Ser Ala Ser Xaa Arg Xaa Lys Asn Gln Ala Lys 
                85                  90                  95      


Lys Xaa Glu Xaa Pro Ser Asn 
            100             


<210>  15
<211>  70
<212>  PRT
<213>  Homo sapiens


<220>
<221>  UNSURE
<222>  (1)..(70)
<223>  Xaa or single letter X represents Selenocystein (U) in originally
       disclosed sequence

<400>  15

Thr Gly Ser Ala Ile Thr Xaa Gln Cys Lys Glu Asn Leu Pro Ser Leu 
1               5                   10                  15      


Cys Ser Xaa Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr Glu Ser Cys 
            20                  25                  30          


Gln Xaa Arg Leu Pro Pro Ala Ala Xaa Gln Ile Ser Gln Gln Leu Ile 
        35                  40                  45              


Pro Thr Glu Ala Ser Ala Ser Xaa Arg Xaa Lys Asn Gln Ala Lys Lys 
    50                  55                  60                  


Xaa Glu Xaa Pro Ser Asn 
65                  70  


