                         SEQUENCE LISTING

<110>  QVQ Holding B.V.
       Leibniz Institute for Natural Product Research and 
       Infection Biology, Hans Knoell Institute
 
<120>  Antibodies for preventing or treating Candidiasis

<130>  P120272PC00

<140>  PCT/NL2019/050875
<141>  2019-12-23

<150>  NL 2022281
<151>  2018-12-21

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-gene hall mark sequence

<400>  2

Lys Gln Arg Glu Leu 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-gene hall mark sequence

<400>  3

Lys Glu Arg Glu Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-gene hall mark sequence

<400>  4

Lys Gly Leu Glu Trp 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-gene hall mark sequence

<400>  5

Lys Glu Arg Glu Phe 
1               5   


<210>  6
<211>  434
<212>  PRT
<213>  Candida albicans

<400>  6

Met Ser Pro Arg Ser Ile Ile Leu Ser Val Val Ala Thr Ala Ala Val 
1               5                   10                  15      


Thr Ile Gly Leu Val Glu Ala Phe His Cys Tyr Glu Arg Lys Lys Ile 
            20                  25                  30          


His Pro Gln Pro Pro Lys Glu Thr Pro Ala Lys Arg Asp His Ser Glu 
        35                  40                  45              


Glu Leu Ile Arg Glu Gln Leu Ala Arg Asn Tyr Ala Phe Leu Thr Glu 
    50                  55                  60                  


Asp Gly Met Asp Lys Val Arg Lys Gln Arg Val Val Val Val Gly Ala 
65                  70                  75                  80  


Gly Gly Val Gly Ser Trp Val Ala Thr Met Leu Ala Arg Ser Gly Val 
                85                  90                  95      


Glu Ser Leu Arg Ile Ile Asp Phe Asp Gln Val Ser Leu Ser Ser Leu 
            100                 105                 110         


Asn Arg His Ala Val Ala Thr Leu Lys Asp Val Gly Ile Pro Lys Val 
        115                 120                 125             


Glu Cys Ile Lys Asn His Leu Leu Glu Ile Ala Pro Trp Ile Glu Ile 
    130                 135                 140                 


Asp Thr Arg Asn Gln Leu Trp Asn Leu Glu Ser Ala Glu Glu Leu Ile 
145                 150                 155                 160 


Tyr Gly Asp Asp Phe Gln Pro Thr Phe Ile Val Asp Cys Ile Asp Asn 
                165                 170                 175     


Leu Asp Thr Lys Cys Asp Leu Leu Ala Tyr Cys His Glu Lys Lys Leu 
            180                 185                 190         


Pro Ile Val Ser Ser Gly Gly Ala Ala Thr Lys Ser Asp Pro Thr Arg 
        195                 200                 205             


Ile Asn Leu Ala Asp Ile Ser Lys Thr Glu Glu Asp Pro Leu Met Lys 
    210                 215                 220                 


Lys Ile Arg Val Val Leu Lys Lys Arg Gly Ile Ile Asn Gly Ile Pro 
225                 230                 235                 240 


Val Val Phe Ser Ala Glu Lys Pro Asp Pro Arg Lys Ala Lys Leu Leu 
                245                 250                 255     


Pro Leu Pro Asp Asp Glu Phe Thr Lys Gly Asn Val Asp Gln Leu Ser 
            260                 265                 270         


Ala Leu Lys Asp Phe Arg Val Arg Ile Leu Pro Val Leu Gly Thr Met 
        275                 280                 285             


Pro Gly Ile Phe Gly Leu Ala Ile Ala Thr Tyr Ile Leu Ser Thr Val 
    290                 295                 300                 


Ala Gly Tyr Pro Met Glu Pro Val Glu Gly Lys Asn Arg Tyr Lys Ile 
305                 310                 315                 320 


Tyr Asp Asp Leu Leu Gln Ser Leu Ala Gly Gln Gln Thr Arg Ile Gly 
                325                 330                 335     


Lys Thr Asp Gln Arg Val Gln Ile Ala Met His Glu Val Asn Tyr Ile 
            340                 345                 350         


Leu Glu Glu Val Phe Arg Gly Lys Ser Pro Ile Ser Asn Tyr Ser Thr 
        355                 360                 365             


Arg Leu Thr Leu Ser Arg Trp Asp Pro Ser Lys Glu Ile Ser Leu Gln 
    370                 375                 380                 


Asn Val Val Val Met Thr Lys Asp Glu Gln Arg Asn His Glu Lys Arg 
385                 390                 395                 400 


Val Leu Asn Gly Gly Glu Lys Ile Glu Asp Val Tyr Ser Lys Glu Val 
                405                 410                 415     


Val Asp Leu Val Lys Ser Arg Phe Glu Asp Glu Lys Tyr Phe Ser Gln 
            420                 425                 430         


Phe Arg 
        


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-P5a

<400>  7

Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly Ala Asn Asp Asp Val Ala 
1               5                   10                  15      


Asn Ala Val Val Arg Leu Pro Glu Ile Val Ala 
            20                  25          


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P5a-FLAG

<400>  8

Asp Gly Ala Asn Asp Asp Val Ala Asn Ala Val Val Arg Leu Pro Glu 
1               5                   10                  15      


Ile Val Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25          


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-P5b

<400>  9

Asp Tyr Lys Asp Asp Asp Asp Lys Val Ala Thr Gly Val Gln Gln Ser 
1               5                   10                  15      


Ile Glu Asn Ala Lys 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P5b-FLAG

<400>  10

Val Ala Thr Gly Val Gln Gln Ser Ile Glu Asn Ala Lys Asp Tyr Lys 
1               5                   10                  15      


Asp Asp Asp Asp Lys 
            20      


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-P6a

<400>  11

Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly Val Pro Asp Val Gly Leu 
1               5                   10                  15      


Asn Leu Val Ala Asn Ala Pro Arg 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P6a-FLAG

<400>  12

Asp Gly Val Pro Asp Val Gly Leu Asn Leu Val Ala Asn Ala Pro Arg 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-P6b

<400>  13

Asp Tyr Lys Asp Asp Asp Asp Lys Leu Ile Ser Asn Val Phe Asp Gly 
1               5                   10                  15      


Val Ser Glu Thr Val Gln Gln Ala Lys 
            20                  25  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P6b-FLAG

<400>  14

Leu Ile Ser Asn Val Phe Asp Gly Val Ser Glu Thr Val Gln Gln Ala 
1               5                   10                  15      


Lys Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25  


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-P7a

<400>  15

Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly Leu Glu Asp Phe Leu Asp 
1               5                   10                  15      


Glu Leu Leu Gln Arg Leu Pro Gln Leu Ile Thr 
            20                  25          


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P7a-FLAG

<400>  16

Asp Gly Leu Glu Asp Phe Leu Asp Glu Leu Leu Gln Arg Leu Pro Gln 
1               5                   10                  15      


Leu Ile Thr Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25          


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-P7b

<400>  17

Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala Glu Ser Ala Leu Lys Asp 
1               5                   10                  15      


Ser Gln Pro Val 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P7b-FLAG

<400>  18

Ser Ala Glu Ser Ala Leu Lys Asp Ser Gln Pro Val Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys 
            20  


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extended C-terminus VHH

<400>  19

Ala Cys Ala Ala 
1               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH C-terminus

<400>  20

Val Thr Val Ser Ser 
1               5   


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc tag

<400>  21

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hexahistidine tag

<400>  22

His His His His His His 
1               5       


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  23

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  24
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  24
gtaaaacgac ggccag                                                       16


<210>  25
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primers

<400>  25
caggaaacag ctatgac                                                      17


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding to adhesion protein Als3


<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  may also be Ala or Ser

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  may also be Gly

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  may also be Ala or Ser

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  may also be Lys or His

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  may also be Val

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  may also be Ala

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Tyr Ser Gly Ser Ala Ile Phe Asp Val 
            20                  25                  30          


Ala Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Thr Ile Thr Val Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Asp Pro Arg Trp Gly Asn Thr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer M13rev-for

<400>  27
gagcggataa caatttcaca cagg                                              24


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer plus F1-CDR3-rev

<400>  28
tgaccccacg aagcatacat cg                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F1-CDR3-for

<400>  29
cgatgtatgc ttcgtggggt ca                                                22


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer plus MPE25-rev

<400>  30
tttctgtatg gggttttgct a                                                 21


<210>  31
<211>  548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pamy-SSamy VHH

<400>  31
aagcttccag atcctggcgg atcaaatcga attgttgccg agaaatatcg ctttggtaat       60

gatgactaaa atgttgcata tgatcaccaa cttttttgac agtagtttat caaattactt      120

ggtcaaaatc aaagatacta aacagcttct aaaaaagcca ataaccacac gcctttggcg      180

tgattatcag ctttcaagtt tcagttacta aaactaatac tgactataaa acagaagcaa      240

aaaaattttc gatttttatg aaaacggttg caaagaagtt agcaaaaata tataatttct      300

tttgaaattg ttcacttggc caagctgcag tttcaatatt ttaataaagg gggcagtaaa      360

aagtgaaaaa aaagaaaagt ttctggcttg tttctttttt agttatagta gctagtgttt      420

tctttatatc ttttggattt agcaatcatt ctaaacaagt tgctcaagcg gctagtgata      480

cgacatcaac tgatcactca agcaatgata cagctgattc tgttagcgac ggtgttattt      540

tgcatgcg                                                               548


<210>  32
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid E-tag

<400>  32
ggtgcgccgg tgccgtatcc ggatccgctg gaacc                                  35


<210>  33
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pamy - SSamy VHH

<400>  33

Met Lys Lys Lys Lys Ser Phe Trp Leu Val Ser Phe Leu Val Ile Val 
1               5                   10                  15      


Ala Ser Val Phe Phe Ile Ser Phe Gly Phe Ser Asn His Ser Lys Gln 
            20                  25                  30          


Val Ala Gln Ala Ala Ser Asp Thr Thr Ser Thr Asp His Ser Ser Asn 
        35                  40                  45              


Asp Thr Ala Asp Ser Val Ser Asp Gly Val Ile Leu His Ala 
    50                  55                  60          


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-tag

<400>  34

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu 
1               5                   10      


<210>  35
<211>  31
<212>  PRT
<213>  Candida albicans

<400>  35

Met Lys Phe Ser Lys Ile Ala Cys Ala Thr Val Phe Ala Leu Ser Ser 
1               5                   10                  15      


Gln Ala Ala Ile Ile His His Ala Pro Glu Phe Asn Met Lys Arg 
            20                  25                  30      


<210>  36
<211>  30
<212>  PRT
<213>  Candida albicans

<400>  36

Asp Val Ala Pro Ala Ala Pro Ala Ala Pro Ala Asp Gln Ala Pro Thr 
1               5                   10                  15      


Val Pro Ala Pro Gln Glu Phe Asn Thr Ala Ile Thr Lys Arg 
            20                  25                  30  


<210>  37
<211>  61
<212>  PRT
<213>  Candida albicans

<400>  37

Asp Val Ala Pro Ala Ala Pro Ala Ala Pro Ala Asp Gln Ala Pro Thr 
1               5                   10                  15      


Val Pro Ala Pro Gln Glu Phe Asn Thr Ala Ile Thr Lys Arg Ser Ile 
            20                  25                  30          


Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val Ile Gln 
        35                  40                  45              


Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn Lys 
    50                  55                  60      


<210>  38
<211>  32
<212>  PRT
<213>  Candida albicans

<400>  38

Ser Ile Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val 
1               5                   10                  15      


Ile Gln Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn Lys Arg 
            20                  25                  30          


<210>  39
<211>  31
<212>  PRT
<213>  Candida albicans

<400>  39

Ser Ile Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val 
1               5                   10                  15      


Ile Gln Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn Lys 
            20                  25                  30      


<210>  40
<211>  30
<212>  PRT
<213>  Candida albicans

<400>  40

Ser Ile Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val 
1               5                   10                  15      


Ile Gln Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn 
            20                  25                  30  


<210>  41
<211>  33
<212>  PRT
<213>  Candida albicans

<400>  41

Glu Asp Ile Asp Ser Val Val Ala Gly Ile Ile Ala Asp Met Pro Phe 
1               5                   10                  15      


Val Val Arg Ala Val Asp Thr Ala Met Thr Ser Val Ala Ser Thr Lys 
            20                  25                  30          


Arg 
    


<210>  42
<211>  34
<212>  PRT
<213>  Candida albicans

<400>  42

Asp Gly Ala Asn Asp Asp Val Ala Asn Ala Val Val Arg Leu Pro Glu 
1               5                   10                  15      


Ile Val Ala Arg Val Ala Thr Gly Val Gln Gln Ser Ile Glu Asn Ala 
            20                  25                  30          


Lys Arg 
        


<210>  43
<211>  19
<212>  PRT
<213>  Candida albicans

<400>  43

Asp Gly Ala Asn Asp Asp Val Ala Asn Ala Val Val Arg Leu Pro Glu 
1               5                   10                  15      


Ile Val Ala 
            


<210>  44
<211>  34
<212>  PRT
<213>  Candida albicans

<400>  44

Asp Gly Val Pro Asp Val Gly Leu Asn Leu Val Ala Asn Ala Pro Arg 
1               5                   10                  15      


Leu Ile Ser Asn Val Phe Asp Gly Val Ser Glu Thr Val Gln Gln Ala 
            20                  25                  30          


Lys Arg 
        


<210>  45
<211>  16
<212>  PRT
<213>  Candida albicans

<400>  45

Asp Gly Val Pro Asp Val Gly Leu Asn Leu Val Ala Asn Ala Pro Arg 
1               5                   10                  15      


<210>  46
<211>  34
<212>  PRT
<213>  Candida albicans

<400>  46

Asp Gly Leu Glu Asp Phe Leu Asp Glu Leu Leu Gln Arg Leu Pro Gln 
1               5                   10                  15      


Leu Ile Thr Arg Ser Ala Glu Ser Ala Leu Lys Asp Ser Gln Pro Val 
            20                  25                  30          


Lys Arg 
        


<210>  47
<211>  12
<212>  PRT
<213>  Candida albicans

<400>  47

Ser Ala Glu Ser Ala Leu Lys Asp Ser Gln Pro Val 
1               5                   10          


<210>  48
<211>  19
<212>  PRT
<213>  Candida albicans

<400>  48

Asp Gly Leu Glu Asp Phe Leu Asp Glu Leu Leu Gln Arg Leu Pro Gln 
1               5                   10                  15      


Leu Ile Thr 
            


<210>  49
<211>  43
<212>  PRT
<213>  Candida albicans

<400>  49

Asp Ala Gly Ser Val Ala Leu Ser Asn Leu Ile Lys Lys Ser Ile Glu 
1               5                   10                  15      


Thr Val Gly Ile Glu Asn Ala Ala Gln Ile Val Ser Glu Arg Asp Ile 
            20                  25                  30          


Ser Ser Leu Ile Glu Glu Tyr Phe Gly Lys Ala 
        35                  40              


<210>  50
<211>  13
<212>  PRT
<213>  Candida albicans

<400>  50

Asp Ile Ser Ser Leu Ile Glu Glu Tyr Phe Gly Lys Ala 
1               5                   10              


<210>  51
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-tagged candidalysin peptide

<400>  51

Ser Ile Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val 
1               5                   10                  15      


Ile Gln Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn Lys 
            20                  25                  30      


<210>  52
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-tagged candidalysin peptide

<400>  52

Ser Ile Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val 
1               5                   10                  15      


Ile Gln Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn Lys Arg 
            20                  25                  30          


<210>  53
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-tagged candidalysin peptide

<400>  53

Ser Ile Ile Gly Ile Ile Met Gly Ile Leu Gly Asn Ile Pro Gln Val 
1               5                   10                  15      


Ile Gln Ile Ile Met Ser Ile Val Lys Ala Phe Lys Gly Asn Lys Asp 
            20                  25                  30          


Tyr Lys Asp Asp Asp Asp Lys 
        35                  


<210>  54
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-tagged candidalysin peptide

<400>  54

Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ile Ile Gly Ile Ile Met Gly 
1               5                   10                  15      


Ile Leu Gly Asn Ile Pro Gln Val Ile Gln Ile Ile Met Ser Ile Val 
            20                  25                  30          


Lys Ala Phe Lys Gly Asn Lys 
        35                  


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  55

Gly Thr Ile Phe Ser Leu Asn 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  56

Thr Ile Thr Glu Thr Thr Gly 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  57

Tyr Asn Asp Tyr Ser Met Tyr Ala Ser 
1               5                   


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  58

Gly Ser Ile Phe Ser Leu Asn 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  59

Thr Leu Thr Glu Thr Thr Gly 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  60

Tyr Asn Asp Tyr Ser Leu Tyr Ala Ser 
1               5                   


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  61

Gly Thr Ile Phe Ser Ile Asn 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  62

Thr Ile Thr Glu Ser Thr Gly 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  63

Tyr Asn Asp Tyr Ser Leu Tyr Ser Ser 
1               5                   


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  64

Gly Ser Leu Phe Ser Ile Asn 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  65

Thr Ile Thr Glu Thr Ser Gly 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  66

Tyr Asn Glu Phe Ser Met Tyr Ala Ser 
1               5                   


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  67

Gly Met Ile Phe Ser Leu Asn 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  68

Thr Ile Thr Asp Thr Thr Gly 
1               5           


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  69

Tyr Asn Glu Tyr Ser Met Phe Ala Ser 
1               5                   


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  70

Thr Leu Thr Asp Thr Thr Gly 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  71

Tyr Asn Glu Tyr Ser Leu Tyr Ala Ser 
1               5                   


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  72

Thr Leu Thr Asp Thr Ser Gly 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  73

Ser Gly Phe Thr Leu Asp Tyr 
1               5           


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  74

Ser Gly Phe Thr Leu Asp Tyr Tyr 
1               5               


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  75

Asp Met Val Tyr Leu Cys Leu Gly Pro Ser Phe Tyr Asp Tyr 
1               5                   10                  


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  76

Ser Gly Tyr Thr Leu Asp Tyr 
1               5           


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  77

Ser Gly Phe Ser Leu Asp Tyr Tyr 
1               5               


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  78

Asp Met Val Leu Cys Gly Ile Ala Pro Ser Phe Tyr Asp Tyr 
1               5                   10                  


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  79

Ser Gly Phe Thr Leu Asp Tyr 
1               5           


<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  80

Asp Met Val Leu Cys Gly Leu Gly Pro Ser Glu Tyr Asp Tyr 
1               5                   10                  


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  81

Ser Gly Tyr Thr Leu Asn Tyr 
1               5           


<210>  82
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  82

Asp Met Val Leu Cys Gly Ala Ala Pro Ser Glu Tyr Asp Tyr 
1               5                   10                  


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  83

Ser Gly Phe Ser Leu Asp Tyr 
1               5           


<210>  84
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  84

Asp Met Val Ile Cys Gly Leu Gly Pro Ser Phe Tyr Asp Tyr 
1               5                   10                  


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  85

Ser Gly Phe Ser Leu Asn Tyr 
1               5           


<210>  86
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  86

Asp Met Val Ile Cys Gly Ala Gly Pro Ser Phe Tyr Asp Tyr 
1               5                   10                  


<210>  87
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  87

Asp Met Val Tyr Leu Cys Leu Gly Pro Ser Tyr Tyr Asp Tyr 
1               5                   10                  


<210>  88
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F1 KQREL subfamily of anti Ece1p and candidalysin VHH


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  may also be Asp

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  may also be Met

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  may also be Gly

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  may also be Tyr

<220>
<221>  VARIANT
<222>  (86)..(86)
<223>  may also be Lys or Asn

<220>
<221>  VARIANT
<222>  (103)..(103)
<223>  may also be Leu

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Thr Ile Phe Ser Leu Asn 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Ile Thr Glu Thr Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Gly Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Tyr Tyr Asn Asp Tyr Ser Met Tyr Ala Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  89
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1 KQREL subfamily of anti Ece1p and candidalysin VHH


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  may also be Asp

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  may also be Gly

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  may also be Trp

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  may also be Ser

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  may also be Thr

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Met Val Leu Cys Gly Leu Gly Pro Ser Phe Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  90
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti ALS3


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  may also be Asp

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  may also be Lys

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  may also be Ala

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Tyr Ser Gly Ser Ala Ile Phe Asp Val 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Val Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Arg Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ser Asp Pro Arg Gly Asn Thr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  91
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti ALS4


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  may also be Lys

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  may also be Phe

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  may also be Pro

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  may also be Ala

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  may also be Leu

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Asn Tyr 
            20                  25                  30          


Gly Gly Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Tyr Ile Ser Ala Ser Gly Lys Thr Thr His Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Thr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Arg Phe Tyr Gly Ser Asn Trp Tyr Ser Ser Asn Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gly-ser linker

<400>  92

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly-ser linker

<400>  93

Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser 
1               5                   10                  15  


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  purification tag

<400>  94

Glu Pro Glu Ala 
1               


