                         SEQUENCE LISTING

<110>  Wisconsin Alumni Research Foundation
       Shusta, Eric V.
       Umlauf, Benjamin J.
       Herrin, Brantley
       Clark, Paul
       Kuo, John
 
<120>  VARIABLE LYMPHOCYTE RECEPTORS THAT TARGET THE BRAIN EXTRACELLULAR
        MATRIX AND METHODS OF USE

<130>  960296.03973

<150>  62/783,475
<151>  2018-12-21

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR clone P1C10

<400>  1

Ala Cys Pro Ser Gln Cys Ser Cys Asp Gln Thr Thr Val Lys Cys His 
1               5                   10                  15      


Ser Arg Arg Leu Thr Ser Val Pro Ala Gly Ile Pro Thr Thr Thr Lys 
            20                  25                  30          


Ile Leu Arg Leu Tyr Ser Asn Gln Ile Thr Lys Leu Glu Pro Gly Val 
        35                  40                  45              


Phe Asp His Leu Val Asn Leu Glu Lys Leu Tyr Ile Ser Trp Asn Gln 
    50                  55                  60                  


Leu Ser Ala Leu Pro Val Gly Val Phe Asp Lys Leu Thr Lys Leu Thr 
65                  70                  75                  80  


His Leu Ser Leu Gly Tyr Asn Gln Leu Lys Ser Val Pro Arg Gly Ala 
                85                  90                  95      


Phe Asp Asn Leu Lys Ser Leu Thr His Ile Trp Leu Leu Asn Asn Pro 
            100                 105                 110         


Trp Asp Cys Glu Cys Ser Asp Ile Leu Tyr Leu Lys Asn Trp Ile Val 
        115                 120                 125             


Gln His Ala Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp Asn 
    130                 135                 140                 


Val Lys Cys Ser Gly Thr Asn Thr Pro Val Arg Ala Val Thr Glu Ala 
145                 150                 155                 160 


Ser Thr Ser Pro Ser Lys Cys Pro 
                165             


<210>  2
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR clone P3A8

<400>  2

Ala Cys Pro Ser Gln Cys Ser Cys Ser Gly Thr Gln Val Asn Cys His 
1               5                   10                  15      


Glu Arg Arg Leu Ala Ser Val Pro Ala Gly Ile Pro Thr Thr Thr Arg 
            20                  25                  30          


Asp Leu Tyr Leu His Asp Asn Gln Ile Thr Lys Leu Glu Pro Gly Val 
        35                  40                  45              


Phe Asp Ser Leu Ala Asn Leu Arg Glu Leu His Leu Trp Gly Asn Gln 
    50                  55                  60                  


Leu Val Ser Leu Pro Pro Gly Val Phe Asp Lys Leu Thr Lys Leu Thr 
65                  70                  75                  80  


His Leu Tyr Leu Gly Tyr Asn Gln Leu Lys Ser Val Pro Arg Gly Ala 
                85                  90                  95      


Phe Asp Asn Leu Lys Ser Leu Thr His Ile Tyr Leu Phe Asn Asn Pro 
            100                 105                 110         


Trp Asp Cys Glu Cys Ser Asp Ile Leu Tyr Leu Lys Asn Trp Ile Val 
        115                 120                 125             


Gln His Ala Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp Asn 
    130                 135                 140                 


Val Lys Cys Ser Gly Thr Asn Thr Pro Val Arg Ala Val Thr Glu Ala 
145                 150                 155                 160 


Ser Thr Ser Pro Ser Lys Cys Pro 
                165             


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic-VLR antigen binding region from clone P1C10


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Thr Xaa Lys Xaa His Ser 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Ile Xaa Arg Xaa Tyr Ser 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Lys Xaa Tyr Xaa Ser Trp 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

His Xaa Ser Xaa Gly Tyr 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

His Xaa Trp Xaa Leu Asn 
1               5       


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR tail region from clone P1C10

<400>  8

Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp 
1               5                   10          


<210>  9
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- generic VLR based on clone P1C10


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (144)..(168)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Lys Xaa His 
1               5                   10                  15      


Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Ile Xaa Arg Xaa Tyr Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Tyr Xaa Ser Trp Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


His Xaa Ser Xaa Gly Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Trp Xaa Leu Asn Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165             


<210>  10
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- generic VLR based on clone P1C10


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (144)..(168)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Val Lys Cys His 
1               5                   10                  15      


Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Ile Leu Arg Leu Tyr Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Leu Tyr Ile Ser Trp Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


His Leu Ser Leu Gly Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Trp Leu Leu Asn Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165             


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10

<400>  11

Thr Val Lys Cys His Ser 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10

<400>  12

Ile Leu Arg Leu Tyr Ser 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10

<400>  13

Lys Leu Tyr Ile Ser Trp 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10

<400>  14

His Leu Ser Leu Gly Tyr 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P1C10

<400>  15

His Ile Trp Leu Leu Asn 
1               5       


<210>  16
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- portion of VLR clone P1C10 comprising antigen binding 
       regions

<400>  16

Thr Val Lys Cys His Ser Arg Arg Leu Thr Ser Val Pro Ala Gly Ile 
1               5                   10                  15      


Pro Thr Thr Thr Lys Ile Leu Arg Leu Tyr Ser Asn Gln Ile Thr Lys 
            20                  25                  30          


Leu Glu Pro Gly Val Phe Asp His Leu Val Asn Leu Glu Lys Leu Tyr 
        35                  40                  45              


Ile Ser Trp Asn Gln Leu Ser Ala Leu Pro Val Gly Val Phe Asp Lys 
    50                  55                  60                  


Leu Thr Lys Leu Thr His Leu Ser Leu Gly Tyr Asn Gln Leu Lys Ser 
65                  70                  75                  80  


Val Pro Arg Gly Ala Phe Asp Asn Leu Lys Ser Leu Thr His Ile Trp 
                85                  90                  95      


Leu Leu Asn Asn Pro Trp Asp Cys Glu Cys Ser Asp Ile Leu Tyr Leu 
            100                 105                 110         


Lys Asn Trp Ile Val Gln His Ala Ser Ile Val Asn Leu Gln Gly His 
        115                 120                 125             


Gly Gly Val Asp 
    130         


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Gln Xaa Asn Xaa His Glu 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Asp Xaa Tyr Xaa His Asp 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Glu Xaa His Xaa Trp Gly 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

His Xaa Tyr Xaa Gly Tyr 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

His Xaa Tyr Xaa Phe Asn 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8

<400>  22

Gln Val Asn Cys His Glu 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8

<400>  23

Asp Leu Tyr Leu His Asp 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8

<400>  24

Glu Leu His Leu Trp Gly 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8

<400>  25

His Leu Tyr Leu Gly Tyr 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VLR antigen binding region from clone P3A8

<400>  26

His Ile Tyr Leu Phe Asn 
1               5       


<210>  27
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- generic VLR based on clone P3A8


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (145)..(168)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Asn Xaa His 
1               5                   10                  15      


Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Asp Xaa Tyr Xaa His Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa His Xaa Trp Gly Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


His Xaa Tyr Xaa Gly Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Tyr Xaa Phe Asn Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp Asn 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165             


<210>  28
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- generic VLR based on clone P3A8


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (145)..(168)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Val Asn Cys His 
1               5                   10                  15      


Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Asp Leu Tyr Leu His Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Leu His Leu Trp Gly Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


His Leu Tyr Leu Gly Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Tyr Leu Phe Asn Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Ser Ile Val Asn Leu Gln Gly His Gly Gly Val Asp Asn 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165             


