                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Ruella, Marco
       Gill, Saar
       June, Carl H.
       Posey, Avery D.
       Powell, Daniel J.
 
<120>  Use of CD2/5/7 Knock-Out Anti-CD2/5/7 Chimeric Antigen Receptor T
        cells Against T Cell Lymphomas and Leukemias

<130>  046483-7224WO1(02147)

<150>  62/782,131
<151>  2018-12-19

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507H2L-3028 CAR

<400>  1
ggatcccaag tccaactggt gcaatcaggc gcagaagtcc aacgaccggg ggccagtgtt       60

aaagtgtctt gtaaagcctc cgggtacatt tttactgagt actatatgta ctgggtcaga      120

caggccccag ggcaaggttt ggaacttgtc ggacgcatag atcccgaaga cggttctata      180

gattacgttg agaagttcaa aaagaaagtc acacttactg cggacacatc tagtagcacc      240

gcatatatgg aactgagcag tctcacctca gacgacaccg cagtgtacta ttgcgctcgc      300

ggaaagttta actataggtt cgcgtactgg ggacagggga cactggtgac tgttagcagc      360

ggtggcggag ggagcggcgg tggaggaagc ggaggcggag gttccgacgt tgtgatgacg      420

caaagtcccc cgtcactcct tgttactctc ggccagccag cgtctatctc ttgccggtca      480

agccagagct tgctccactc tagtggtaac acgtatttga actggttgct gcaaaggcct      540

ggacaatctc ctcagcccct gatctatttg gttagcaaac tggaaagtgg tgttccagac      600

agattttcag ggtctggatc aggcactgat ttcactctga agatctccgg ggtagaggcc      660

gaggacgtgg gagtctatta ctgcatgcag tttactcact atccttatac ctttggtcaa      720

gggacgaaac tggagatcaa atccgga                                          747


<210>  2
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11H2L-3029

<400>  2
ggatcccaag ttcagcttca gcaaccaggt gctgaattgg tccgccctgg aactagcgtt       60

aaactgtctt gtaaggcatc cggttatacg tttacaagtt attggatgca ctggattaag      120

caaaggcccg aacaaggcct tgaatggatt gggagaattg atccctacga tagcgagaca      180

cactacaatg aaaaatttaa agataaggcc atcctcagcg tagataagag cagttctacc      240

gcatacatac agctctcaag cctgacgtca gatgactcag ccgtttatta ttgctcaagg      300

cgggacgcta aatacgacgg ctatgcgctt gactactggg gacaaggcac cactttgaca      360

gtctccagtg gtggcggagg gagcggcggt ggaggaagcg gaggcggagg ttccgatata      420

gttatgacgc aagcagcacc ctctgtacct gtgacaccgg gtgaatccgt tagtatctca      480

tgccgctctt ctaaaaccct cttgcattct aacggcaata catatttgta ttggttcctt      540

caacgaccag gacaatcacc gcaagtgctt atttatagga tgtctaactt ggctagtggg      600

gtgccaaata ggttcagtgg gtctggatct gagacaactt tcacgttgag aataagtagg      660

gtggaagctg aagacgtcgg tatatactac tgtatgcagc atttggagta cccttacact      720

ttcgggggag gtactaagct cgaaattaaa tccgga                                756


<210>  3
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11L2H-3030 CAR

<400>  3
ggatccgata tagttatgac gcaagcagca ccctctgtac ctgtgacacc gggtgaatcc       60

gttagtatct catgccgctc ttctaaaacc ctcttgcatt ctaacggcaa tacatatttg      120

tattggttcc ttcaacgacc aggacaatca ccgcaagtgc ttatttatag gatgtctaac      180

ttggctagtg gggtgccaaa taggttcagt gggtctggat ctgagacaac tttcacgttg      240

agaataagta gggtggaagc tgaagacgtc ggtatatact actgtatgca gcatttggag      300

tacccttaca ctttcggggg aggtactaag ctcgaaatta aaggtggcgg agggagcggc      360

ggtggaggaa gcggaggcgg aggttcccaa gttcagcttc agcaaccagg tgctgaattg      420

gtccgccctg gaactagcgt taaactgtct tgtaaggcat ccggttatac gtttacaagt      480

tattggatgc actggattaa gcaaaggccc gaacaaggcc ttgaatggat tgggagaatt      540

gatccctacg atagcgagac acactacaat gaaaaattta aagataaggc catcctcagc      600

gtagataaga gcagttctac cgcatacata cagctctcaa gcctgacgtc agatgactca      660

gccgtttatt attgctcaag gcgggacgct aaatacgacg gctatgcgct tgactactgg      720

ggacaaggca ccactttgac agtctccagt tccgga                                756


<210>  4
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2-H2L-3031 CAR

<400>  4
ggatcccaag ttcaattgca gcaaccgggt gccgagttgg taaggcccgg tgcgtcagtc       60

aaacttagtt gtaaagctag tgggtacact tttactacgt tctggatgaa ttgggtgaag      120

caacgaccag gccaaggtct ggaatggatc ggcatgattg acccgtctga ctcagaagct      180

cattacaacc agatgttcaa ggacaaggcg actctgactg ttgataaaag ctcaagcacc      240

gcctacatgc agctcagtag cctcacatcc gaggattccg cagtgtacta ttgcgcgagg      300

ggacgagggt atgatgacgg cgatgcgatg gactattggg gacaggggac cagcgtaaca      360

gtcagtagtg gtggcggagg gagcggcggt ggaggaagcg gaggcggagg ttccgatata      420

gttatgaccc agtctcccgc ctctctggcc gttagcttgg gacaacgcgc taccatctct      480

taccgagcgt ctaagtccgt cagtacaagc ggttatagtt acatgcactg gaaccagcaa      540

aagcccggac aacctccgag actcctgatt tatttggtct ctaaccttga gtcaggtgtc      600

ccagccagat tctccggctc tggaagcggc actgacttta cattgaacat tcaccccgtg      660

gaggaggaag acgctgctac ctactattgc atgcaattca cgcactatcc ctacacattc      720

ggggggggca cgaaattgga aatcaaatcc gga                                   753


<210>  5
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1-H2L-3032 CAR

<400>  5
ggatccgagg ttcagcttga ggagagtggg ggaggtttgg taatgccagg tgggtctttg       60

aaactcagtt gcgcggcgtc aggcttcgca ttttcctcct acgatatgtc ctgggtcaga      120

cagacacccg agaagcggct ggaatgggtc gcttacattt ccgggggagg attcacgtac      180

tacccggata cagtaaaggg gagatttact ctgagccggg acaacgctaa gaataccctc      240

tatctccaga tgtcctcttt gaagagtgaa gacacagcga tgtattactg tgcgagacaa      300

ggggccaatt gggagctggt ttactggggc caggggacga cattgacggt ttctagcggt      360

ggcggaggga gcggcggtgg aggaagcgga ggcggaggtt ccgacattgt aatgacacaa      420

tcacctgcta cacttagcgt gactccaggt gatcgggtat tcctgagctg ccgcgcatca      480

caaagtatat ccgacttcct gcactggtat cagcagaaat ctcacgaaag tcccaggctg      540

ctgattaaat acgcttccca gagtattagt ggtatcccct cacgattttc tggcagcggg      600

agcggtagtg acttcactct ttctataaac tccgtcgagc cagaagacgt gggggtgtat      660

ctttgccaaa atggacacaa ttttccacca acctttggtg ggggcaccaa actcgaaata      720

aagtccgga                                                              729


<210>  6
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1-L2H-3033 CAR

<400>  6
ggatccgaca ttgtaatgac acaatcacct gctacactta gcgtgactcc aggtgatcgg       60

gtattcctga gctgccgcgc atcacaaagt atatccgact tcctgcactg gtatcagcag      120

aaatctcacg aaagtcccag gctgctgatt aaatacgctt cccagagtat tagtggtatc      180

ccctcacgat tttctggcag cgggagcggt agtgacttca ctctttctat aaactccgtc      240

gagccagaag acgtgggggt gtatctttgc caaaatggac acaattttcc accaaccttt      300

ggtgggggca ccaaactcga aataaagggt ggcggaggga gcggcggtgg aggaagcgga      360

ggcggaggtt ccgaggttca gcttgaggag agtgggggag gtttggtaat gccaggtggg      420

tctttgaaac tcagttgcgc ggcgtcaggc ttcgcatttt cctcctacga tatgtcctgg      480

gtcagacaga cacccgagaa gcggctggaa tgggtcgctt acatttccgg gggaggattc      540

acgtactacc cggatacagt aaaggggaga tttactctga gccgggacaa cgctaagaat      600

accctctatc tccagatgtc ctctttgaag agtgaagaca cagcgatgta ttactgtgcg      660

agacaagggg ccaattggga gctggtttac tggggccagg ggacgacatt gacggtttct      720

agctccgga                                                              729


<210>  7
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507L2H-3043 CAR

<400>  7
ggatccgacg ttgtgatgac gcaaagtccc ccgtcactcc ttgttactct cggccagcca       60

gcgtctatct cttgccggtc aagccagagc ttgctccact ctagtggtaa cacgtatttg      120

aactggttgc tgcaaaggcc tggacaatct cctcagcccc tgatctattt ggttagcaaa      180

ctggaaagtg gtgttccaga cagattttca gggtctggat caggcactga tttcactctg      240

aagatctccg gggtagaggc cgaggacgtg ggagtctatt actgcatgca gtttactcac      300

tatccttata cctttggtca agggacgaaa ctggagatca aaggtggcgg agggagcggc      360

ggtggaggaa gcggaggcgg aggttcccaa gtccaactgg tgcaatcagg cgcagaagtc      420

caacgaccgg gggccagtgt taaagtgtct tgtaaagcct ccgggtacat ttttactgag      480

tactatatgt actgggtcag acaggcccca gggcaaggtt tggaacttgt cggacgcata      540

gatcccgaag acggttctat agattacgtt gagaagttca aaaagaaagt cacacttact      600

gcggacacat ctagtagcac cgcatatatg gaactgagca gtctcacctc agacgacacc      660

gcagtgtact attgcgctcg cggaaagttt aactataggt tcgcgtactg gggacagggg      720

acactggtga ctgttagcag ctccgga                                          747


<210>  8
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD5-17L2H-3045 CAR

<400>  8
ggatccaaca ttgtactgac gcaaagcccc tcatctttgt ctgagtcact cggcggcaaa       60

gtaaccatca catgcaaggc cagtcaagac atcaataaat atattgcttg gtatcagtat      120

aaacccggca aggggccgcg actgctgatt cactacacga gtaccttgca accgggcatt      180

ccgagccgat ttagtggcag tggctcaggt cgcgattact cattctcaat aagtaatctc      240

gaaccggaag acatagctac ttattattgc ttgcagtacg ataatttgtg gaccttcggg      300

ggtggtacaa agttggaaat aaagggtggc ggagggagcg gcggtggagg aagcggaggc      360

ggaggttccg aggtccaact cgtagaatca ggtcccggat tggtgcaacc atcccagagc      420

ctctctatta catgcacggt ctctggattt agtctgacca attacgatgt gcattgggtg      480

cgccagtctc ccggcaaggg gttggaatgg cttggcgtta tatggaacta cggaaataca      540

gactataacg ccgcgtttat ctctcggctg agtatacgga aagacagtag taaatcccag      600

gtctttttta cgatgtcatc cctgcaaacg ccagataccg caatatatta ctgcgccagg      660

aaccacggtg atggttatta taattggtac ttcgatgtgt ggggtactgg cactacagtc      720

acagtatctt catctaga                                                    738


<210>  9
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD5-9H2L-3048 CAR

<400>  9
ggatcccagg tccagctgaa agaaagcggt ccagagctgg aaaaacccgg tgcgagcgtc       60

aaaatatcat gtaaagcaag cgggtattca ttcaccgcgt actctatgaa ctgggttaag      120

caaaacaacg gtatgtcctt ggagtggata gggtctatcg acccgtatta tggggacaca      180

aaatacgcgc agaaattcaa ggggaaggcc accctgaccg tagataaagc tagttctact      240

gcgtacttgc aactgaaaag cctcacttct gaggactctg ccgtctacta ctgtgctcgg      300

cgaatgataa cgacggggga ctggtatttc gatgtttggg gtacagggac tacggtgact      360

gtcagtagcg gtggcggagg gagcggcggt ggaggaagcg gaggcggagg ttcccatatc      420

gtcttgactc aatcacctag ttctttgtct gcgtcccttg gcgaccgagt caccatatct      480

tgcagagcgt cacaggacat ttcaacgtac ctcaactggt atcagcaaaa accggacggg      540

actgtcaagc tcttgatctt ctacacttcc agactccacg ccggggtgcc aagcagattt      600

agtggctctg gcagcgggac acaccatagt cttacaatca gcaatcttga gcaagaagac      660

atagccacgt atttctgcca gcaaggtaac tcacttccgt tcacgtttgg tagtggcacc      720

aaactggaga taaaatccgg a                                                741


<210>  10
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD5-9L2H-3049 CAR

<400>  10
ggatcccata tcgtcttgac tcaatcacct agttctttgt ctgcgtccct tggcgaccga       60

gtcaccatat cttgcagagc gtcacaggac atttcaacgt acctcaactg gtatcagcaa      120

aaaccggacg ggactgtcaa gctcttgatc ttctacactt ccagactcca cgccggggtg      180

ccaagcagat ttagtggctc tggcagcggg acacaccata gtcttacaat cagcaatctt      240

gagcaagaag acatagccac gtatttctgc cagcaaggta actcacttcc gttcacgttt      300

ggtagtggca ccaaactgga gataaaaggt ggcggaggga gcggcggtgg aggaagcgga      360

ggcggaggtt cccaggtcca gctgaaagaa agcggtccag agctggaaaa acccggtgcg      420

agcgtcaaaa tatcatgtaa agcaagcggg tattcattca ccgcgtactc tatgaactgg      480

gttaagcaaa acaacggtat gtccttggag tggatagggt ctatcgaccc gtattatggg      540

gacacaaaat acgcgcagaa attcaagggg aaggccaccc tgaccgtaga taaagctagt      600

tctactgcgt acttgcaact gaaaagcctc acttctgagg actctgccgt ctactactgt      660

gctcggcgaa tgataacgac gggggactgg tatttcgatg tttggggtac agggactacg      720

gtgactgtca gtagctccgg a                                                741


<210>  11
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD5-34H2L-3052 CAR

<400>  11
ggatccgagg ttaaactcgt ggagagcggt gccgaactcg tccgaagtgg tgcttccgtt       60

aaactcagtt gtgccgcgtc aggatttaac ataaaagatt actacattca ctgggtcaaa      120

cagcgcccgg agcaggggct tgaatggatc gggtggattg atcctgaaaa cgggcgcacc      180

gaatatgctc ccaagttcca gggcaaagct actatgaccg ctgacacctc tagtaacact      240

gcctacctgc agttgagctc tcttacgtct gaggataccg ctgtgtacta ctgtaataac      300

ggaaattatg tacgacacta ttacttcgac tactgggggc agggcactac tgtgactgta      360

tctagcggtg gcggagggag cggcggtgga ggaagcggag gcggaggttc cgattggctc      420

acacaatccc ctgcaatcct gagtgcatct ccaggcgaga aagtaactat gacttgcaga      480

gctataagct ctgtgtccta catgcactgg tatcagcaga agccaggttc ttccccgaag      540

ccgtggatat atgctacaag caatttggca tccggtgttc ccgcccggtt tagtggctcc      600

ggttctggga caagttactc cctcacgatc agcagggttg aagccgagga cgctgccact      660

tactattgcc aacagtggtc aagtaacccc aggactttcg ggggaggaac taaacttgaa      720

atcaaatcta ga                                                          732


<210>  12
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD5-34L2H-3053 CAR

<400>  12
ggatccgatt ggctcacaca atcccctgca atcctgagtg catctccagg cgagaaagta       60

actatgactt gcagagctat aagctctgtg tcctacatgc actggtatca gcagaagcca      120

ggttcttccc cgaagccgtg gatatatgct acaagcaatt tggcatccgg tgttcccgcc      180

cggtttagtg gctccggttc tgggacaagt tactccctca cgatcagcag ggttgaagcc      240

gaggacgctg ccacttacta ttgccaacag tggtcaagta accccaggac tttcggggga      300

ggaactaaac ttgaaatcaa aggtggcgga gggagcggcg gtggaggaag cggaggcgga      360

ggttccgagg ttaaactcgt ggagagcggt gccgaactcg tccgaagtgg tgcttccgtt      420

aaactcagtt gtgccgcgtc aggatttaac ataaaagatt actacattca ctgggtcaaa      480

cagcgcccgg agcaggggct tgaatggatc gggtggattg atcctgaaaa cgggcgcacc      540

gaatatgctc ccaagttcca gggcaaagct actatgaccg ctgacacctc tagtaacact      600

gcctacctgc agttgagctc tcttacgtct gaggataccg ctgtgtacta ctgtaataac      660

ggaaattatg tacgacacta ttacttcgac tactgggggc agggcactac tgtgactgta      720

tctagctcta ga                                                          732


<210>  13
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD5-17H2L-3054 CAR

<400>  13
ggatccgagg tccaactcgt agaatcaggt cccggattgg tgcaaccatc ccagagcctc       60

tctattacat gcacggtctc tggatttagt ctgaccaatt acgatgtgca ttgggtgcgc      120

cagtctcccg gcaaggggtt ggaatggctt ggcgttatat ggaactacgg aaatacagac      180

tataacgccg cgtttatctc tcggctgagt atacggaaag acagtagtaa atcccaggtc      240

ttttttacga tgtcatccct gcaaacgcca gataccgcaa tatattactg cgccaggaac      300

cacggtgatg gttattataa ttggtacttc gatgtgtggg gtactggcac tacagtcaca      360

gtatcttcag gtggcggagg gagcggcggt ggaggaagcg gaggcggagg ttccaacatt      420

gtactgacgc aaagcccctc atctttgtct gagtcactcg gcggcaaagt aaccatcaca      480

tgcaaggcca gtcaagacat caataaatat attgcttggt atcagtataa acccggcaag      540

gggccgcgac tgctgattca ctacacgagt accttgcaac cgggcattcc gagccgattt      600

agtggcagtg gctcaggtcg cgattactca ttctcaataa gtaatctcga accggaagac      660

atagctactt attattgctt gcagtacgat aatttgtgga ccttcggggg tggtacaaag      720

ttggaaataa agtctaga                                                    738


<210>  14
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  14
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  15

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  16
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  16
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  17
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  17

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  18
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  18
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  19
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3-zeta

<400>  19
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  20
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  20

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta

<400>  21

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  22
acagctgaca ggctcgacac                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  23
cggctcagct ggtatgaccc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  24
ggagcaggtg atgttgacgg                                                   20


<210>  25
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507H2L-3028 CAR

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Gln Arg Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Ile Phe Thr Glu Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Leu Val Gly Arg Ile Asp Pro Glu Asp Gly Ser 
65                  70                  75                  80  


Ile Asp Tyr Val Glu Lys Phe Lys Lys Lys Val Thr Leu Thr Ala Asp 
                85                  90                  95      


Thr Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Phe Asn Tyr Arg Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Pro Ser Leu Leu Val Thr Leu Gly Gln Pro Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr 
            180                 185                 190         


Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Gln Pro Leu 
        195                 200                 205             


Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Gly Val Glu 
225                 230                 235                 240 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe Thr His Tyr Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  26
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507L2H-3043 CAR

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Val Met Thr Gln Ser Pro Pro 
            20                  25                  30          


Ser Leu Leu Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr Tyr Leu Asn Trp Leu 
    50                  55                  60                  


Leu Gln Arg Pro Gly Gln Ser Pro Gln Pro Leu Ile Tyr Leu Val Ser 
65                  70                  75                  80  


Lys Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Gly Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Met Gln Phe Thr His Tyr Pro Tyr Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Gln Arg Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Ile Phe Thr Glu Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Leu Val Gly Arg Ile Asp Pro Glu Asp Gly Ser Ile 
        195                 200                 205             


Asp Tyr Val Glu Lys Phe Lys Lys Lys Val Thr Leu Thr Ala Asp Thr 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Asp Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Phe Asn Tyr Arg Phe Ala 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  27
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507H2L-3028 scFv

<400>  27

Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Gln Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr 
            20                  25                  30          


Glu Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Leu Val Gly Arg Ile Asp Pro Glu Asp Gly Ser Ile Asp Tyr Val Glu 
    50                  55                  60                  


Lys Phe Lys Lys Lys Val Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Lys Phe Asn Tyr Arg Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Pro 
    130                 135                 140                 


Ser Leu Leu Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr Tyr Leu Asn Trp Leu 
                165                 170                 175     


Leu Gln Arg Pro Gly Gln Ser Pro Gln Pro Leu Ile Tyr Leu Val Ser 
            180                 185                 190         


Lys Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Gly Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Met Gln Phe Thr His Tyr Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ser Gly 
                245                 


<210>  28
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507L2H-3043 scFv

<400>  28

Gly Ser Asp Val Val Met Thr Gln Ser Pro Pro Ser Leu Leu Val Thr 
1               5                   10                  15      


Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
            20                  25                  30          


His Ser Ser Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Pro Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
                85                  90                  95      


Gln Phe Thr His Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Gln Arg Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Glu 
145                 150                 155                 160 


Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Leu 
                165                 170                 175     


Val Gly Arg Ile Asp Pro Glu Asp Gly Ser Ile Asp Tyr Val Glu Lys 
            180                 185                 190         


Phe Lys Lys Lys Val Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Lys Phe Asn Tyr Arg Phe Ala Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ser Gly 
                245                 


<210>  29
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 VH

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Gln Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Glu Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Leu Val 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Ser Ile Asp Tyr Val Glu Lys Phe 
    50                  55                  60                  


Lys Lys Lys Val Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Phe Asn Tyr Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 VL

<400>  30

Asp Val Val Met Thr Gln Ser Pro Pro Ser Leu Leu Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Pro Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      


Thr His Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 HCDR1

<400>  31

Glu Tyr Tyr Met Tyr 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 HCDR2

<400>  32

Arg Ile Asp Pro Glu Asp Gly Ser Ile Asp Tyr Val Glu Lys Phe Lys 
1               5                   10                  15      


Lys 
    


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 HCDR3

<400>  33

Gly Lys Phe Asn Tyr Arg Phe Ala Tyr 
1               5                   


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 LCDR1

<400>  34

Arg Ser Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 LCDR2

<400>  35

Leu Val Ser Lys Leu Glu Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-MEDI507 LCDR3

<400>  36

Met Gln Phe Thr His Tyr Pro Tyr Thr 
1               5                   


<210>  37
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11H2L-3029 CAR

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
65                  70                  75                  80  


Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu Ser Val Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Asp 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys Tyr Asp Gly 
        115                 120                 125             


Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu 
                165                 170                 175     


Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu His Ser Asn 
            180                 185                 190         


Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asn 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr Phe Thr Leu Arg Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His Leu 
                245                 250                 255     


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser 
            260                 265                 270         


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  38
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11L2H-3030 CAR

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Met Thr Gln Ala Ala Pro 
            20                  25                  30          


Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Lys Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe 
    50                  55                  60                  


Leu Gln Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser 
65                  70                  75                  80  


Asn Leu Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu 
                85                  90                  95      


Thr Thr Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Ile Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
145                 150                 155                 160 


Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Glu 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr 
        195                 200                 205             


His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu Ser Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr 
                245                 250                 255     


Ala Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser 
            260                 265                 270         


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  39
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11H2L-3029 scFv

<400>  39

Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 


Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Lys Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu 
                165                 170                 175     


Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr 
            180                 185                 190         


Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Glu Thr Thr Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Val Gly Ile Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly 
                245                 250         


<210>  40
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11L2H-3030 scFv

<400>  40

Gly Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr 
1               5                   10                  15      


Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu 
            20                  25                  30          


His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly 
    50                  55                  60                  


Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr Phe Thr Leu 
65                  70                  75                  80  


Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met 
                85                  90                  95      


Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Gly 
                245                 250         


<210>  41
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 VH

<400>  41

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 VL

<400>  42

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 HCDR1

<400>  43

Ser Tyr Trp Met His 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 HCDR2

<400>  44

Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 HCDR3

<400>  45

Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr 
1               5                   10          


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 LCDR1

<400>  46

Arg Ser Ser Lys Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 LCDR2

<400>  47

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-OKT11 LCDR3

<400>  48

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  49
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2-H2L-3031 CAR

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Thr Phe Trp Met Asn Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu 
65                  70                  75                  80  


Ala His Tyr Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Arg Gly Tyr Asp Asp Gly 
        115                 120                 125             


Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
                165                 170                 175     


Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly 
            180                 185                 190         


Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        195                 200                 205             


Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
225                 230                 235                 240 


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Met Gln Phe Thr His 
                245                 250                 255     


Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  50
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2-H2L-3031 scFv

<400>  50

Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Thr Phe Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Ala His Tyr Asn Gln 
    50                  55                  60                  


Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Arg Gly Tyr Asp Asp Gly Asp Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
145                 150                 155                 160 


Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
                165                 170                 175     


Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu 
            180                 185                 190         


Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp 
    210                 215                 220                 


Ala Ala Thr Tyr Tyr Cys Met Gln Phe Thr His Tyr Pro Tyr Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly 
                245                 250     


<210>  51
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2-H2L-3031 VH

<400>  51

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Ala His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Tyr Asp Asp Gly Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  52
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2-H2L-3031 VL

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Met Gln Phe Thr 
                85                  90                  95      


His Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2 HCDR1

<400>  53

Thr Phe Trp Met Asn 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2 HCDR2

<400>  54

Met Ile Asp Pro Ser Asp Ser Glu Ala His Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2 HCDR3

<400>  55

Gly Arg Gly Tyr Asp Asp Gly Asp Ala Met Asp Tyr 
1               5                   10          


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2 LCDR1

<400>  56

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2 LCDR2

<400>  57

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-T11-2 LCDR3

<400>  58

Met Gln Phe Thr His Tyr Pro Tyr Thr 
1               5                   


<210>  59
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1-H2L-3032 CAR

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Met Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Ala Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Thr Pro 
    50                  55                  60                  


Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser Gly Gly Gly Phe Thr 
65                  70                  75                  80  


Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Gly Ala Asn Trp Glu Leu Val 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Phe Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Phe Leu His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln 
        195                 200                 205             


Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser 
    210                 215                 220                 


Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val 
225                 230                 235                 240 


Tyr Leu Cys Gln Asn Gly His Asn Phe Pro Pro Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  60
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1-L2H-3033 CAR

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Val Thr Pro Gly Asp Arg Val Phe Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Ser Asp Phe Leu His Trp Tyr Gln Gln Lys Ser His 
    50                  55                  60                  


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu 
                85                  90                  95      


Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Leu Cys Gln 
            100                 105                 110         


Asn Gly His Asn Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Met Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser 
                165                 170                 175     


Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp 
            180                 185                 190         


Val Ala Tyr Ile Ser Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Thr Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Gln Gly Ala Asn Trp Glu Leu Val Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Leu Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  61
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1-H2L-3032 scFv

<400>  61

Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Met Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30          


Ser Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
        35                  40                  45              


Trp Val Ala Tyr Ile Ser Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Thr 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Gly Ala Asn Trp Glu Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Asp Arg Val Phe Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Asp Phe Leu His Trp Tyr Gln Gln Lys Ser His Glu 
                165                 170                 175     


Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser 
        195                 200                 205             


Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Leu Cys Gln Asn 
    210                 215                 220                 


Gly His Asn Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly 
            


<210>  62
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1-L2H-3033 scFv

<400>  62

Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr 
1               5                   10                  15      


Pro Gly Asp Arg Val Phe Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Asp Phe Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 
        35                  40                  45              


Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val 
65                  70                  75                  80  


Glu Pro Glu Asp Val Gly Val Tyr Leu Cys Gln Asn Gly His Asn Phe 
                85                  90                  95      


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Glu Glu Ser Gly Gly Gly Leu Val Met Pro Gly Gly Ser Leu Lys Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr Asp Met Ser Trp 
145                 150                 155                 160 


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser 
                165                 170                 175     


Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser 
        195                 200                 205             


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Gly Ala 
    210                 215                 220                 


Asn Trp Glu Leu Val Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Ser Gly 
            


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 VH

<400>  63

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Met Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Gly Ala Asn Trp Glu Leu Val Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 VL

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Phe Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Phe 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Leu Cys Gln Asn Gly His Asn Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 HCDR1

<400>  65

Ser Tyr Asp Met Ser 
1               5   


<210>  66
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 HCDR2

<400>  66

Tyr Ile Ser Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 HCDR3

<400>  67

Gln Gly Ala Asn Trp Glu Leu Val Tyr 
1               5                   


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 LCDR1

<400>  68

Arg Ala Ser Gln Ser Ile Ser Asp Phe Leu His 
1               5                   10      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 LCDR2

<400>  69

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2-TS2-18.1.1 LCDR3

<400>  70

Gln Asn Gly His Asn Phe Pro Pro Thr 
1               5                   


<210>  71
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-17L2H-3045 CAR

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asn Ile Val Leu Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Glu Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln Tyr Lys Pro Gly 
    50                  55                  60                  


Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe 
                85                  90                  95      


Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Tyr Asp Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
                165                 170                 175     


Asp Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Asn Tyr Gly Asn Thr Asp Tyr Asn Ala Ala Phe Ile 
        195                 200                 205             


Ser Arg Leu Ser Ile Arg Lys Asp Ser Ser Lys Ser Gln Val Phe Phe 
    210                 215                 220                 


Thr Met Ser Ser Leu Gln Thr Pro Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asn His Gly Asp Gly Tyr Tyr Asn Trp Tyr Phe Asp Val Trp Gly 
                245                 250                 255     


Thr Gly Thr Thr Val Thr Val Ser Ser Ser Arg Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


His Met Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Thr Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  72
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-17H2L-3054 CAR

<400>  72

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        35                  40                  45              


Gly Phe Ser Leu Thr Asn Tyr Asp Val His Trp Val Arg Gln Ser Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Asn Tyr Gly Asn Thr 
65                  70                  75                  80  


Asp Tyr Asn Ala Ala Phe Ile Ser Arg Leu Ser Ile Arg Lys Asp Ser 
                85                  90                  95      


Ser Lys Ser Gln Val Phe Phe Thr Met Ser Ser Leu Gln Thr Pro Asp 
            100                 105                 110         


Thr Ala Ile Tyr Tyr Cys Ala Arg Asn His Gly Asp Gly Tyr Tyr Asn 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Glu Ser Leu Gly Gly 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr Ile 
            180                 185                 190         


Ala Trp Tyr Gln Tyr Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile His 
        195                 200                 205             


Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Arg Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


His Met Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Thr Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  73
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-17L2H-3045 scFv

<400>  73

Asn Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Glu Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Tyr Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr 
    130                 135                 140                 


Val Ser Gly Phe Ser Leu Thr Asn Tyr Asp Val His Trp Val Arg Gln 
145                 150                 155                 160 


Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Asn Tyr Gly 
                165                 170                 175     


Asn Thr Asp Tyr Asn Ala Ala Phe Ile Ser Arg Leu Ser Ile Arg Lys 
            180                 185                 190         


Asp Ser Ser Lys Ser Gln Val Phe Phe Thr Met Ser Ser Leu Gln Thr 
        195                 200                 205             


Pro Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Asn His Gly Asp Gly Tyr 
    210                 215                 220                 


Tyr Asn Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  74
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-17H2L-3054 scFv

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Asp Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Asn Tyr Gly Asn Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Ser Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Thr Met Ser Ser Leu Gln Thr Pro Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn His Gly Asp Gly Tyr Tyr Asn Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Glu Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln Tyr Lys Pro 
                165                 170                 175     


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
            180                 185                 190         


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
        195                 200                 205             


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Leu Gln Tyr Asp Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-17 VH

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Asp Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Asn Tyr Gly Asn Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Ser Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Thr Met Ser Ser Leu Gln Thr Pro Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn His Gly Asp Gly Tyr Tyr Asn Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-17 VL

<400>  76

Asn Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Glu Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Tyr Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  77
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9H2L-3048 CAR

<400>  77

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            20                  25                  30          


Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Ser Phe Thr Ala Tyr Ser Met Asn Trp Val Lys Gln Asn Asn 
    50                  55                  60                  


Gly Met Ser Leu Glu Trp Ile Gly Ser Ile Asp Pro Tyr Tyr Gly Asp 
65                  70                  75                  80  


Thr Lys Tyr Ala Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Lys Ala Ser Ser Thr Ala Tyr Leu Gln Leu Lys Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Met Ile Thr Thr Gly Asp 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Thr Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe 
        195                 200                 205             


Tyr Thr Ser Arg Leu His Ala Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr His His Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ser Gly Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  78
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9L2H-3049 CAR

<400>  78

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser His Ile Val Leu Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Phe Tyr Thr Ser Arg Leu His Ala Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His His Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Ser Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Glu Lys Pro Gly 
145                 150                 155                 160 


Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala 
                165                 170                 175     


Tyr Ser Met Asn Trp Val Lys Gln Asn Asn Gly Met Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Ser Ile Asp Pro Tyr Tyr Gly Asp Thr Lys Tyr Ala Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ala Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Arg Met Ile Thr Thr Gly Asp Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  79
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9H2L-3048 scFv

<400>  79

Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Glu Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Ala Tyr Ser Met Asn Trp Val Lys Gln Asn Asn Gly Met Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Asp Pro Tyr Tyr Gly Asp Thr Lys Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ala Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Met Ile Thr Thr Gly Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Asp Ile Ser Thr Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Thr Ser Arg Leu 
            180                 185                 190         


His Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His 
        195                 200                 205             


His Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Gly Asn Ser Leu Pro Phe Thr Phe Gly Ser Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Ser Gly 
                245         


<210>  80
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9L2H-3049 scFv

<400>  80

His Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu His Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His His Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu 
        115                 120                 125             


Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr Ser Met Asn Trp Val Lys 
145                 150                 155                 160 


Gln Asn Asn Gly Met Ser Leu Glu Trp Ile Gly Ser Ile Asp Pro Tyr 
                165                 170                 175     


Tyr Gly Asp Thr Lys Tyr Ala Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ala Ser Ser Thr Ala Tyr Leu Gln Leu Lys Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Met Ile Thr 
    210                 215                 220                 


Thr Gly Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  81
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 VH

<400>  81

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Asn Asn Gly Met Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Tyr Tyr Gly Asp Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ala Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Met Ile Thr Thr Gly Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 VL

<400>  82

His Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu His Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His His Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 HCDR1

<400>  83

Ala Tyr Ser Met Asn 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 HCDR2

<400>  84

Ser Ile Asp Pro Tyr Tyr Gly Asp Thr Lys Tyr Ala Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 HCDR3

<400>  85

Arg Met Ile Thr Thr Gly Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 LCDR1

<400>  86

Arg Ala Ser Gln Asp Ile Ser Thr Tyr Leu Asn 
1               5                   10      


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 LCDR2

<400>  87

Tyr Thr Ser Arg Leu His Ala 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-9 LCDR3

<400>  88

Gln Gln Gly Asn Ser Leu Pro Phe Thr 
1               5                   


<210>  89
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34H2L-3052 CAR

<400>  89

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Lys Leu Val Glu Ser Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Ser Gly Ala Ser Val Lys Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Arg 
65                  70                  75                  80  


Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp 
                85                  90                  95      


Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Asn Asn Gly Asn Tyr Val Arg His Tyr 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Trp 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
                165                 170                 175     


Thr Met Thr Cys Arg Ala Ile Ser Ser Val Ser Tyr Met His Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser 
        195                 200                 205             


Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Arg Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ser Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys His Met 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Thr Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  90
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34L2H-3053 CAR

<400>  90

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Trp Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ile 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Val Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala Ser 
145                 150                 155                 160 


Val Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr 
                165                 170                 175     


Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Trp Ile Asp Pro Glu Asn Gly Arg Thr Glu Tyr Ala Pro Lys Phe Gln 
        195                 200                 205             


Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Asn Gly Asn Tyr Val Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Thr Val Thr Val Ser Ser Ser Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys His Met 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Thr Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  91
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34H2L-3052 scFv

<400>  91

Glu Val Lys Leu Val Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Arg Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Asn Gly Asn Tyr Val Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Trp Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ile 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  92
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34L2H-3053 scFv

<400>  92

Asp Trp Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
1               5                   10                  15      


Lys Val Thr Met Thr Cys Arg Ala Ile Ser Ser Val Ser Tyr Met His 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        35                  40                  45              


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
65                  70                  75                  80  


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Arg Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly 
        115                 120                 125             


Ala Glu Leu Val Arg Ser Gly Ala Ser Val Lys Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Lys Gln Arg 
145                 150                 155                 160 


Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly 
                165                 170                 175     


Arg Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala 
            180                 185                 190         


Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Asn Gly Asn Tyr Val Arg His 
    210                 215                 220                 


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  93
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 VH

<400>  93

Glu Val Lys Leu Val Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Arg Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Asn Gly Asn Tyr Val Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  94
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 VL

<400>  94

Asp Trp Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
1               5                   10                  15      


Lys Val Thr Met Thr Cys Arg Ala Ile Ser Ser Val Ser Tyr Met His 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        35                  40                  45              


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
65                  70                  75                  80  


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Arg Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Arg 
            100                 105         


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 HCDR1

<400>  95

Asp Tyr Tyr Ile His 
1               5   


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 HCDR2

<400>  96

Trp Ile Asp Pro Glu Asn Gly Arg Thr Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 HCDR3

<400>  97

Gly Asn Tyr Val Arg His Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 LCDR1

<400>  98

Arg Ala Ile Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 LCDR2

<400>  99

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-34 LCDR3

<400>  100

Gln Gln Trp Ser Ser Asn Pro Arg Thr 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dextramer

<400>  101

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


