                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Xu, Ziyang
       Kulp, Daniel W
       Weiner, David B
 
<120>  COMPOSITIONS COMPRISING SELF-ASSEMBLING VACCINES AND METHODS OF 
       USING THE SAME

<130>  37925.0004P1

<150>  62/784,318
<151>  2018-12-21

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader

<400>  1
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagc             54


<210>  2
<211>  462
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Self-assembling polypeptide from lumazine synthase of Aquifex 
       aeolicus

<400>  2
atgcagatct acgaaggaaa actgaccgct gagggactga ggttcggaat tgtcgcaagc       60

cgcgcgaatc acgcactggt ggataggctg gtggaaggcg ctatcgacgc aattgtccgg      120

cacggcggga gagaggaaga catcacactg gtgagagtct gcggcagctg ggagattccc      180

gtggcagctg gagaactggc tcgaaaggag gacatcgatg ccgtgatcgc tattggggtc      240

ctgtgccgag gagcaactcc cagcttcgac tacatcgcct cagaagtgag caaggggctg      300

gctgatctgt ccctggagct gaggaaacct atcacttttg gcgtgattac tgccgacacc      360

ctggaacagg caatcgaggc ggccggcacc tgccatggaa acaaaggctg ggaagcagcc      420

ctgtgcgcta ttgagatggc aaatctgttc aaatctctgc ga                         462


<210>  3
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker

<400>  3
ggaggctccg gaggatctgg agggagtgga ggctcaggag gaggc                       45


<210>  4
<211>  516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fragment of gp120

<400>  4
gacaccatca cactgccatg ccgccctgca ccacctccac attgtagctc caacatcacc       60

ggcctgattc tgacaagaca ggggggatat agtaacgata ataccgtgat tttcaggccc      120

tcaggagggg actggaggga catcgcacga tgccagattg ctggaacagt ggtctctact      180

cagctgtttc tgaacggcag tctggctgag gaagaggtgg tcatccgatc tgaagactgg      240

cgggataatg caaagtcaat ttgtgtgcag ctgaacacaa gcgtcgagat caattgcact      300

ggcgcagggc actgtaacat ttctcgggcc aaatggaaca ataccctgaa gcagatcgcc      360

agtaaactga gagagcagta cggcaataag acaatcatct tcaagccttc tagtggaggc      420

gacccagagt tcgtgaacca tagctttaat tgcgggggag agttctttta ttgtgattcc      480

acacagctgt tcaacagcac ttggtttaat tccacc                                516


<210>  5
<211>  1083
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Expressible nucleic acid sequence encoding antigen of SEQ ID NO: 
       10

<400>  5
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagcatgcag       60

atctacgaag gaaaactgac cgctgaggga ctgaggttcg gaattgtcgc aagccgcgcg      120

aatcacgcac tggtggatag gctggtggaa ggcgctatcg acgcaattgt ccggcacggc      180

gggagagagg aagacatcac actggtgaga gtctgcggca gctgggagat tcccgtggca      240

gctggagaac tggctcgaaa ggaggacatc gatgccgtga tcgctattgg ggtcctgtgc      300

cgaggagcaa ctcccagctt cgactacatc gcctcagaag tgagcaaggg gctggctgat      360

ctgtccctgg agctgaggaa acctatcact tttggcgtga ttactgccga caccctggaa      420

caggcaatcg aggcggccgg cacctgccat ggaaacaaag gctgggaagc agccctgtgc      480

gctattgaga tggcaaatct gttcaaatct ctgcgaggag gctccggagg atctggaggg      540

agtggaggct caggaggagg cgacaccatc acactgccat gccgccctgc accacctcca      600

cattgtagct ccaacatcac cggcctgatt ctgacaagac aggggggata tagtaacgat      660

aataccgtga ttttcaggcc ctcaggaggg gactggaggg acatcgcacg atgccagatt      720

gctggaacag tggtctctac tcagctgttt ctgaacggca gtctggctga ggaagaggtg      780

gtcatccgat ctgaagactg gcgggataat gcaaagtcaa tttgtgtgca gctgaacaca      840

agcgtcgaga tcaattgcac tggcgcaggg cactgtaaca tttctcgggc caaatggaac      900

aataccctga agcagatcgc cagtaaactg agagagcagt acggcaataa gacaatcatc      960

ttcaagcctt ctagtggagg cgacccagag ttcgtgaacc atagctttaa ttgcggggga     1020

gagttctttt attgtgattc cacacagctg ttcaacagca cttggtttaa ttccacctga     1080

taa                                                                   1083


<210>  6
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgE leader sequence encoded by SEQ ID NO: 1

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  7
<211>  154
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Self-assembling polypeptide encoded by SEQ ID NO:2

<400>  7

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Ala Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Cys Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Cys Arg Gly Ala Thr Pro Ser Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Ala Ala 
        115                 120                 125             


Gly Thr Cys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Cys Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker encoded by SEQ ID NO:3

<400>  8

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210>  9
<211>  172
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Viral antigen encoded by SEQ ID NO:4

<400>  9

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gln Gly Gly Tyr Ser Asn 
            20                  25                  30          


Asp Asn Thr Val Ile Phe Arg Pro Ser Gly Gly Asp Trp Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Trp 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Tyr Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Asn His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  10
<211>  359
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antigen encoded by SEQ ID NO:5

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg 
            20                  25                  30          


Phe Gly Ile Val Ala Ser Arg Ala Asn His Ala Leu Val Asp Arg Leu 
        35                  40                  45              


Val Glu Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu 
    50                  55                  60                  


Asp Ile Thr Leu Val Arg Val Cys Gly Ser Trp Glu Ile Pro Val Ala 
65                  70                  75                  80  


Ala Gly Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile 
                85                  90                  95      


Gly Val Leu Cys Arg Gly Ala Thr Pro Ser Phe Asp Tyr Ile Ala Ser 
            100                 105                 110         


Glu Val Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro 
        115                 120                 125             


Ile Thr Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu 
    130                 135                 140                 


Ala Ala Gly Thr Cys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Cys 
145                 150                 155                 160 


Ala Ile Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Asp Thr Ile Thr Leu 
            180                 185                 190         


Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser Ser Asn Ile Thr Gly 
        195                 200                 205             


Leu Ile Leu Thr Arg Gln Gly Gly Tyr Ser Asn Asp Asn Thr Val Ile 
    210                 215                 220                 


Phe Arg Pro Ser Gly Gly Asp Trp Arg Asp Ile Ala Arg Cys Gln Ile 
225                 230                 235                 240 


Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu Asn Gly Ser Leu Ala 
                245                 250                 255     


Glu Glu Glu Val Val Ile Arg Ser Glu Asp Trp Arg Asp Asn Ala Lys 
            260                 265                 270         


Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly 
        275                 280                 285             


Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys 
    290                 295                 300                 


Gln Ile Ala Ser Lys Leu Arg Glu Gln Tyr Gly Asn Lys Thr Ile Ile 
305                 310                 315                 320 


Phe Lys Pro Ser Ser Gly Gly Asp Pro Glu Phe Val Asn His Ser Phe 
                325                 330                 335     


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn 
            340                 345                 350         


Ser Thr Trp Phe Asn Ser Thr 
        355                 


<210>  11
<211>  594
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IgE-GLT1 ( IgE leader and a fragment of gp120)

<400>  11
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc cacaagggtg       60

cacagcgaca ccatcacact gccatgccgc cctgcaccac ctccacattg tagctccaac      120

atcaccggcc tgattctgac aagacagggg ggatatagta acgataatac cgtgattttc      180

aggccctcag gaggggactg gagggacatc gcacgatgcc agattgctgg aacagtggtc      240

tctactcagc tgtttctgaa cggcagtctg gctgaggaag aggtggtcat ccgatctgaa      300

gactggcggg ataatgcaaa gtcaatttgt gtgcagctga acacaagcgt cgagatcaat      360

tgcactggcg cagggcactg taacatttct cgggccaaat ggaacaatac cctgaagcag      420

atcgccagta aactgagaga gcagtacggc aataagacaa tcatcttcaa gccttctagt      480

ggaggcgacc cagagttcgt gaaccatagc tttaattgcg ggggagagtt cttttattgt      540

gattccacac agctgttcaa cagcacttgg tttaattcca cctgataact cgag            594


<210>  12
<211>  190
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgE-gp120 encoded by SEQ ID NO:11

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His 
            20                  25                  30          


Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gln Gly Gly Tyr 
        35                  40                  45              


Ser Asn Asp Asn Thr Val Ile Phe Arg Pro Ser Gly Gly Asp Trp Arg 
    50                  55                  60                  


Asp Ile Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu 
65                  70                  75                  80  


Phe Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
                85                  90                  95      


Asp Trp Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser 
            100                 105                 110         


Val Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala 
        115                 120                 125             


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
    130                 135                 140                 


Tyr Gly Asn Lys Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro 
145                 150                 155                 160 


Glu Phe Val Asn His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
                165                 170                 175     


Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
            180                 185                 190 


<210>  13
<211>  501
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Self-assembling polypeptide 3BVE

<400>  13
gggctgagta aggacattat caagctgctg aacgaacagg tgaacaaaga gatgcagtct       60

agcaacctgt acatgtccat gagctcctgg tgctataccc actctctgga cggagcaggc      120

ctgttcctgt ttgatcacgc cgccgaggag tacgagcacg ccaagaagct gatcatcttc      180

ctgaatgaga acaatgtgcc cgtgcagctg acctctatca gcgcccctga gcacaagttc      240

gagggcctga cacagatctt tcagaaggcc tacgagcacg agcagcacat ctccgagtct      300

atcaacaata tcgtggacca cgccatcaag tccaaggatc acgccacatt caactttctg      360

cagtggtacg tggccgagca gcacgaggag gaggtgctgt ttaaggacat cctggataag      420

atcgagctga tcggcaatga gaaccacggg ctgtacctgg cagatcagta tgtcaagggc      480

atcgctaagt caaggaaaag c                                                501


<210>  14
<211>  1032
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Self-assembling polypeptide RBE

<400>  14
ctgagcattg cccccacact gattaaccgg gacaaaccct acaccaaaga ggaactgatg       60

gagattctga gactggctat tatcgctgag ctggacgcca tcaacctgta cgagcagatg      120

gcccggtatt ctgaggacga gaatgtgcgc aagatcctgc tggatgtggc cagggaggag      180

aaggcacacg tgggagagtt catggccctg ctgctgaacc tggaccccga gcaggtgacc      240

gagctgaagg gcggctttga ggaggtgaag gagctgacag gcatcgaggc ccacatcaac      300

gacaataaga aggaggagag caacgtggag tatttcgaga agctgagatc cgccctgctg      360

gatggcgtga ataagggcag gagcctgctg aagcacctgc ctgtgaccag gatcgagggc      420

cagagcttca gagtggacat catcaagttt gaggatggcg tgcgcgtggt gaagcaggag      480

tacaagccca tccctctgct gaagaagaag ttctacgtgg gcatcaggga gctgaacgac      540

ggcacctacg atgtgagcat cgccacaaag gccggcgagc tgctggtgaa ggacgaggag      600

tccctggtca tccgcgagat cctgtctaca gagggcatca agaagatgaa gctgagctcc      660

tgggacaatc cagaggaggc cctgaacgat ctgatgaatg ccctgcagga ggcatctaac      720

gcaagcgccg gaccattcgg cctgatcatc aatcccaaga gatacgccaa gctgctgaag      780

atctatgaga agtccggcaa gatgctggtg gaggtgctga aggagatctt ccggggcggc      840

atcatcgtga ccctgaacat cgatgagaac aaagtgatca tctttgccaa cacccctgcc      900

gtgctggacg tggtggtggg acaggatgtg acactgcagg agctgggacc agagggcgac      960

gatgtggcct ttctggtgtc cgaggccatc ggcatcagga tcaagaatcc agaggcaatc     1020

gtggtgctgg ag                                                         1032


<210>  15
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Self-assembling polypeptide I3

<400>  15
gagaaagcag ccaaagcaga ggaagcagca cggaagatgg aagaactgtt caagaagcac       60

aagatcgtgg ccgtgctgag ggccaactcc gtggaggagg ccaagaagaa ggccctggcc      120

gtgttcctgg gcggcgtgca cctgatcgag atcaccttta cagtgcccga cgccgatacc      180

gtgatcaagg agctgtcttt cctgaaggag atgggagcaa tcatcggagc aggaaccgtg      240

acaagcgtgg agcagtgcag aaaggccgtg gagagcggcg ccgagtttat cgtgtcccct      300

cacctggacg aggagatctc tcagttctgt aaggagaagg gcgtgtttta catgccaggc      360

gtgatgaccc ccacagagct ggtgaaggcc atgaagctgg gccacacaat cctgaagctg      420

ttccctggcg aggtggtggg cccacagttt gtgaaggcca tgaagggccc cttccctaat      480

gtgaagtttg tgcccaccgg cggcgtgaac ctggataacg tgtgcgagtg gttcaaggca      540

ggcgtgctgg cagtgggcgt gggcagcgcc ctggtgaagg gcacacccgt ggaagtcgct      600

gagaaggcaa aggcattcgt ggaaaagatt agggggtgta ctgag                      645


<210>  16
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker

<400>  16
ggcggctctg gcggaagtgg cggaagtggg ggaagtggag gcggcggaag cgggggaggc       60

agcgggggag gg                                                           72


<210>  17
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker

<400>  17
ggcggaagcg gcggaagcgg cgggtct                                           27


<210>  18
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker 4QTL-115 Angstroms, single chain 3-helix bundle

<400>  18

Asn Glu Asp Asp Met Lys Lys Leu Tyr Lys Gln Met Val Gln Glu Leu 
1               5                   10                  15      


Glu Lys Ala Arg Asp Arg Met Glu Lys Leu Tyr Lys Glu Met Val Glu 
            20                  25                  30          


Leu Ile Gln Lys Ala Ile Glu Leu Met Arg Lys Ile Phe Gln Glu Val 
        35                  40                  45              


Lys Gln Glu Val Glu Lys Ala Ile Glu Glu Met Lys Lys Leu Tyr Asp 
    50                  55                  60                  


Glu Ala Lys Lys Lys Ile Glu Gln Met Ile Gln Gln Ile Lys Gln Gly 
65                  70                  75                  80  


Gly Asp Lys Gln Lys Met Glu Glu Leu Leu Lys Arg Ala Lys Glu Glu 
                85                  90                  95      


Met Lys Lys Val Lys Asp Lys Met Glu Lys Leu Leu Glu Lys Leu Lys 
            100                 105                 110         


Gln Ile Met Gln Glu Ala Lys Gln Lys Met Glu Lys Leu Leu Lys Gln 
        115                 120                 125             


Leu Lys Glu Glu Met Lys Lys Met Lys Glu Lys Met Glu Lys Leu Leu 
    130                 135                 140                 


Lys Glu Met Lys Gln Arg Met Glu Glu Val Lys Lys Lys Met Asp Gly 
145                 150                 155                 160 


Asp Asp Glu Leu Leu Glu Lys Ile Lys Lys Asn Ile Asp Asp Leu Lys 
                165                 170                 175     


Lys Ile Ala Glu Asp Leu Ile Lys Lys Ala Glu Glu Asn Ile Lys Glu 
            180                 185                 190         


Ala Lys Lys Ile Ala Glu Gln Leu Val Lys Arg Ala Lys Gln Leu Ile 
        195                 200                 205             


Glu Lys Ala Lys Gln Val Ala Glu Glu Leu Ile Lys Lys Ile Leu Gln 
    210                 215                 220                 


Leu Ile Glu Lys Ala Lys Glu Ile Ala Glu Lys Val Leu Lys Gly Leu 
225                 230                 235                 240 


Glu 
    


<210>  19
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker

<400>  19
ggcggcagcg gcggcagcgg cgggagcgga ggaagt                                 36


<210>  20
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IgE-GLT1-3BVE

<400>  20
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagcgacacc       60

atcacactgc catgccgccc tgcaccacct ccacattgta gctccaacat caccggcctg      120

attctgacaa gacagggggg atatagtaac gataataccg tgattttcag gccctcagga      180

ggggactgga gggacatcgc acgatgccag attgctggaa cagtggtctc tactcagctg      240

tttctgaacg gcagtctggc tgaggaagag gtggtcatcc gatctgaaga ctggcgggat      300

aatgcaaagt caatttgtgt gcagctgaac acaagcgtcg agatcaattg cactggcgca      360

gggcactgta acatttctcg ggccaaatgg aacaataccc tgaagcagat cgccagtaaa      420

ctgagagagc agtacggcaa taagacaatc atcttcaagc cttctagtgg aggcgaccca      480

gagttcgtga accatagctt taattgcggg ggagagttct tttattgtga ttccacacag      540

ctgttcaaca gcacttggtt taattccacc ggcggaagcg gcggaagcgg cgggtctggg      600

ctgagtaagg acattatcaa gctgctgaac gaacaggtga acaaagagat gcagtctagc      660

aacctgtaca tgtccatgag ctcctggtgc tatacccact ctctggacgg agcaggcctg      720

ttcctgtttg atcacgccgc cgaggagtac gagcacgcca agaagctgat catcttcctg      780

aatgagaaca atgtgcccgt gcagctgacc tctatcagcg cccctgagca caagttcgag      840

ggcctgacac agatctttca gaaggcctac gagcacgagc agcacatctc cgagtctatc      900

aacaatatcg tggaccacgc catcaagtcc aaggatcacg ccacattcaa ctttctgcag      960

tggtacgtgg ccgagcagca cgaggaggag gtgctgttta aggacatcct ggataagatc     1020

gagctgatcg gcaatgagaa ccacgggctg tacctggcag atcagtatgt caagggcatc     1080

gctaagtcaa ggaaaagctg ataa                                            1104


<210>  21
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgE-GLT1-3BVE

<400>  21

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His 
            20                  25                  30          


Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gln Gly Gly Tyr 
        35                  40                  45              


Ser Asn Asp Asn Thr Val Ile Phe Arg Pro Ser Gly Gly Asp Trp Arg 
    50                  55                  60                  


Asp Ile Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu 
65                  70                  75                  80  


Phe Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
                85                  90                  95      


Asp Trp Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser 
            100                 105                 110         


Val Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala 
        115                 120                 125             


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
    130                 135                 140                 


Tyr Gly Asn Lys Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro 
145                 150                 155                 160 


Glu Phe Val Asn His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
                165                 170                 175     


Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Gly Gly 
            180                 185                 190         


Ser Gly Gly Ser Gly Gly Ser Gly Leu Ser Lys Asp Ile Ile Lys Leu 
        195                 200                 205             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    210                 215                 220                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
225                 230                 235                 240 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                245                 250                 255     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            260                 265                 270         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        275                 280                 285             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    290                 295                 300                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
305                 310                 315                 320 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                325                 330                 335     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            340                 345                 350         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        355                 360                 365     


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  22

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  23
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  3BVE scaffold

<400>  23

Gly Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys 
1               5                   10                  15      


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
            20                  25                  30          


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
        35                  40                  45              


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
    50                  55                  60                  


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
65                  70                  75                  80  


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
                85                  90                  95      


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
            100                 105                 110         


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
        115                 120                 125             


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
    130                 135                 140                 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
145                 150                 155                 160 


Ile Ala Lys Ser Arg Lys Ser 
                165         


<210>  24
<211>  1257
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IgE-GLT1-I3

<400>  24
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagcgacacc       60

atcacactgc catgccgccc tgcaccacct ccacattgta gctccaacat caccggcctg      120

attctgacaa gacagggggg atatagtaac gataataccg tgattttcag gccctcagga      180

ggggactgga gggacatcgc acgatgccag attgctggaa cagtggtctc tactcagctg      240

tttctgaacg gcagtctggc tgaggaagag gtggtcatcc gatctgaaga ctggcgggat      300

aatgcaaagt caatttgtgt gcagctgaac acaagcgtcg agatcaattg cactggcgca      360

gggcactgta acatttctcg ggccaaatgg aacaataccc tgaagcagat cgccagtaaa      420

ctgagagagc agtacggcaa taagacaatc atcttcaagc cttctagtgg aggcgaccca      480

gagttcgtga accatagctt taattgcggg ggagagttct tttattgtga ttccacacag      540

ctgttcaaca gcacttggtt taattccacc ggcggcagcg gcggcagcgg cgggagcgga      600

ggaagtgaga aagcagccaa agcagaggaa gcagcacgga agatggaaga actgttcaag      660

aagcacaaga tcgtggccgt gctgagggcc aactccgtgg aggaggccaa gaagaaggcc      720

ctggccgtgt tcctgggcgg cgtgcacctg atcgagatca cctttacagt gcccgacgcc      780

gataccgtga tcaaggagct gtctttcctg aaggagatgg gagcaatcat cggagcagga      840

accgtgacaa gcgtggagca gtgcagaaag gccgtggaga gcggcgccga gtttatcgtg      900

tcccctcacc tggacgagga gatctctcag ttctgtaagg agaagggcgt gttttacatg      960

ccaggcgtga tgacccccac agagctggtg aaggccatga agctgggcca cacaatcctg     1020

aagctgttcc ctggcgaggt ggtgggccca cagtttgtga aggccatgaa gggccccttc     1080

cctaatgtga agtttgtgcc caccggcggc gtgaacctgg ataacgtgtg cgagtggttc     1140

aaggcaggcg tgctggcagt gggcgtgggc agcgccctgg tgaagggcac acccgtggaa     1200

gtcgctgaga aggcaaaggc attcgtggaa aagattaggg ggtgtactga gtgataa        1257


<210>  25
<211>  417
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgE-GLT1-I3

<400>  25

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His 
            20                  25                  30          


Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gln Gly Gly Tyr 
        35                  40                  45              


Ser Asn Asp Asn Thr Val Ile Phe Arg Pro Ser Gly Gly Asp Trp Arg 
    50                  55                  60                  


Asp Ile Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu 
65                  70                  75                  80  


Phe Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
                85                  90                  95      


Asp Trp Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser 
            100                 105                 110         


Val Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala 
        115                 120                 125             


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
    130                 135                 140                 


Tyr Gly Asn Lys Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro 
145                 150                 155                 160 


Glu Phe Val Asn His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
                165                 170                 175     


Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Gly Gly 
            180                 185                 190         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala 
        195                 200                 205             


Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile 
    210                 215                 220                 


Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Lys Lys Lys Ala 
225                 230                 235                 240 


Leu Ala Val Phe Leu Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr 
                245                 250                 255     


Val Pro Asp Ala Asp Thr Val Ile Lys Glu Leu Ser Phe Leu Lys Glu 
            260                 265                 270         


Met Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys 
        275                 280                 285             


Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu 
    290                 295                 300                 


Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met 
305                 310                 315                 320 


Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly 
                325                 330                 335     


His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe 
            340                 345                 350         


Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr 
        355                 360                 365             


Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val 
    370                 375                 380                 


Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Val Glu 
385                 390                 395                 400 


Val Ala Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr 
                405                 410                 415     


Glu 
    


<210>  26
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I3 scaffold

<400>  26

Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu 
1               5                   10                  15      


Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu 
            20                  25                  30          


Glu Ala Lys Lys Lys Ala Leu Ala Val Phe Leu Gly Gly Val His Leu 
        35                  40                  45              


Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Glu 
    50                  55                  60                  


Leu Ser Phe Leu Lys Glu Met Gly Ala Ile Ile Gly Ala Gly Thr Val 
65                  70                  75                  80  


Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe 
                85                  90                  95      


Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu 
            100                 105                 110         


Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val 
        115                 120                 125             


Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu 
    130                 135                 140                 


Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn 
145                 150                 155                 160 


Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu 
                165                 170                 175     


Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val 
            180                 185                 190         


Lys Gly Thr Pro Val Glu Val Ala Glu Lys Ala Lys Ala Phe Val Glu 
        195                 200                 205             


Lys Ile Arg Gly Cys Thr Glu 
    210                 215 


<210>  27
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  27

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  28
<211>  1674
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IgE-GLT1-RBE

<400>  28
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagcctgagc       60

attgccccca cactgattaa ccgggacaaa ccctacacca aagaggaact gatggagatt      120

ctgagactgg ctattatcgc tgagctggac gccatcaacc tgtacgagca gatggcccgg      180

tattctgagg acgagaatgt gcgcaagatc ctgctggatg tggccaggga ggagaaggca      240

cacgtgggag agttcatggc cctgctgctg aacctggacc ccgagcaggt gaccgagctg      300

aagggcggct ttgaggaggt gaaggagctg acaggcatcg aggcccacat caacgacaat      360

aagaaggagg agagcaacgt ggagtatttc gagaagctga gatccgccct gctggatggc      420

gtgaataagg gcaggagcct gctgaagcac ctgcctgtga ccaggatcga gggccagagc      480

ttcagagtgg acatcatcaa gtttgaggat ggcgtgcgcg tggtgaagca ggagtacaag      540

cccatccctc tgctgaagaa gaagttctac gtgggcatca gggagctgaa cgacggcacc      600

tacgatgtga gcatcgccac aaaggccggc gagctgctgg tgaaggacga ggagtccctg      660

gtcatccgcg agatcctgtc tacagagggc atcaagaaga tgaagctgag ctcctgggac      720

aatccagagg aggccctgaa cgatctgatg aatgccctgc aggaggcatc taacgcaagc      780

gccggaccat tcggcctgat catcaatccc aagagatacg ccaagctgct gaagatctat      840

gagaagtccg gcaagatgct ggtggaggtg ctgaaggaga tcttccgggg cggcatcatc      900

gtgaccctga acatcgatga gaacaaagtg atcatctttg ccaacacccc tgccgtgctg      960

gacgtggtgg tgggacagga tgtgacactg caggagctgg gaccagaggg cgacgatgtg     1020

gcctttctgg tgtccgaggc catcggcatc aggatcaaga atccagaggc aatcgtggtg     1080

ctggagggcg gctctggcgg aagtggcgga agtgggggaa gtggaggcgg cggaagcggg     1140

ggaggcagcg ggggagggga caccatcaca ctgccatgcc gccctgcacc acctccacat     1200

tgtagctcca acatcaccgg cctgattctg acaagacagg ggggatatag taacgataat     1260

accgtgattt tcaggccctc aggaggggac tggagggaca tcgcacgatg ccagattgct     1320

ggaacagtgg tctctactca gctgtttctg aacggcagtc tggctgagga agaggtggtc     1380

atccgatctg aagactggcg ggataatgca aagtcaattt gtgtgcagct gaacacaagc     1440

gtcgagatca attgcactgg cgcagggcac tgtaacattt ctcgggccaa atggaacaat     1500

accctgaagc agatcgccag taaactgaga gagcagtacg gcaataagac aatcatcttc     1560

aagccttcta gtggaggcga cccagagttc gtgaaccata gctttaattg cgggggagag     1620

ttcttttatt gtgattccac acagctgttc aacagcactt ggtttaattc cacc           1674


<210>  29
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker

<400>  29
ggcggctctg gcggaagtgg cggaagtggg ggaagtggag gcggcggaag cgggggaggc       60

agcgggggag gg                                                           72


<210>  30
<211>  558
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgE leader-RBE-linker-HIV antigen

<400>  30

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Leu Ser Ile Ala Pro Thr Leu Ile Asn Arg Asp Lys Pro Tyr 
            20                  25                  30          


Thr Lys Glu Glu Leu Met Glu Ile Leu Arg Leu Ala Ile Ile Ala Glu 
        35                  40                  45              


Leu Asp Ala Ile Asn Leu Tyr Glu Gln Met Ala Arg Tyr Ser Glu Asp 
    50                  55                  60                  


Glu Asn Val Arg Lys Ile Leu Leu Asp Val Ala Arg Glu Glu Lys Ala 
65                  70                  75                  80  


His Val Gly Glu Phe Met Ala Leu Leu Leu Asn Leu Asp Pro Glu Gln 
                85                  90                  95      


Val Thr Glu Leu Lys Gly Gly Phe Glu Glu Val Lys Glu Leu Thr Gly 
            100                 105                 110         


Ile Glu Ala His Ile Asn Asp Asn Lys Lys Glu Glu Ser Asn Val Glu 
        115                 120                 125             


Tyr Phe Glu Lys Leu Arg Ser Ala Leu Leu Asp Gly Val Asn Lys Gly 
    130                 135                 140                 


Arg Ser Leu Leu Lys His Leu Pro Val Thr Arg Ile Glu Gly Gln Ser 
145                 150                 155                 160 


Phe Arg Val Asp Ile Ile Lys Phe Glu Asp Gly Val Arg Val Val Lys 
                165                 170                 175     


Gln Glu Tyr Lys Pro Ile Pro Leu Leu Lys Lys Lys Phe Tyr Val Gly 
            180                 185                 190         


Ile Arg Glu Leu Asn Asp Gly Thr Tyr Asp Val Ser Ile Ala Thr Lys 
        195                 200                 205             


Ala Gly Glu Leu Leu Val Lys Asp Glu Glu Ser Leu Val Ile Arg Glu 
    210                 215                 220                 


Ile Leu Ser Thr Glu Gly Ile Lys Lys Met Lys Leu Ser Ser Trp Asp 
225                 230                 235                 240 


Asn Pro Glu Glu Ala Leu Asn Asp Leu Met Asn Ala Leu Gln Glu Ala 
                245                 250                 255     


Ser Asn Ala Ser Ala Gly Pro Phe Gly Leu Ile Ile Asn Pro Lys Arg 
            260                 265                 270         


Tyr Ala Lys Leu Leu Lys Ile Tyr Glu Lys Ser Gly Lys Met Leu Val 
        275                 280                 285             


Glu Val Leu Lys Glu Ile Phe Arg Gly Gly Ile Ile Val Thr Leu Asn 
    290                 295                 300                 


Ile Asp Glu Asn Lys Val Ile Ile Phe Ala Asn Thr Pro Ala Val Leu 
305                 310                 315                 320 


Asp Val Val Val Gly Gln Asp Val Thr Leu Gln Glu Leu Gly Pro Glu 
                325                 330                 335     


Gly Asp Asp Val Ala Phe Leu Val Ser Glu Ala Ile Gly Ile Arg Ile 
            340                 345                 350         


Lys Asn Pro Glu Ala Ile Val Val Leu Glu Gly Gly Ser Gly Gly Ser 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His 
385                 390                 395                 400 


Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gln Gly Gly Tyr 
                405                 410                 415     


Ser Asn Asp Asn Thr Val Ile Phe Arg Pro Ser Gly Gly Asp Trp Arg 
            420                 425                 430         


Asp Ile Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu 
        435                 440                 445             


Phe Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
    450                 455                 460                 


Asp Trp Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser 
465                 470                 475                 480 


Val Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala 
                485                 490                 495     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            500                 505                 510         


Tyr Gly Asn Lys Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro 
        515                 520                 525             


Glu Phe Val Asn His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
    530                 535                 540                 


Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
545                 550                 555             


<210>  31
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RBE scaffold

<400>  31

Leu Ser Ile Ala Pro Thr Leu Ile Asn Arg Asp Lys Pro Tyr Thr Lys 
1               5                   10                  15      


Glu Glu Leu Met Glu Ile Leu Arg Leu Ala Ile Ile Ala Glu Leu Asp 
            20                  25                  30          


Ala Ile Asn Leu Tyr Glu Gln Met Ala Arg Tyr Ser Glu Asp Glu Asn 
        35                  40                  45              


Val Arg Lys Ile Leu Leu Asp Val Ala Arg Glu Glu Lys Ala His Val 
    50                  55                  60                  


Gly Glu Phe Met Ala Leu Leu Leu Asn Leu Asp Pro Glu Gln Val Thr 
65                  70                  75                  80  


Glu Leu Lys Gly Gly Phe Glu Glu Val Lys Glu Leu Thr Gly Ile Glu 
                85                  90                  95      


Ala His Ile Asn Asp Asn Lys Lys Glu Glu Ser Asn Val Glu Tyr Phe 
            100                 105                 110         


Glu Lys Leu Arg Ser Ala Leu Leu Asp Gly Val Asn Lys Gly Arg Ser 
        115                 120                 125             


Leu Leu Lys His Leu Pro Val Thr Arg Ile Glu Gly Gln Ser Phe Arg 
    130                 135                 140                 


Val Asp Ile Ile Lys Phe Glu Asp Gly Val Arg Val Val Lys Gln Glu 
145                 150                 155                 160 


Tyr Lys Pro Ile Pro Leu Leu Lys Lys Lys Phe Tyr Val Gly Ile Arg 
                165                 170                 175     


Glu Leu Asn Asp Gly Thr Tyr Asp Val Ser Ile Ala Thr Lys Ala Gly 
            180                 185                 190         


Glu Leu Leu Val Lys Asp Glu Glu Ser Leu Val Ile Arg Glu Ile Leu 
        195                 200                 205             


Ser Thr Glu Gly Ile Lys Lys Met Lys Leu Ser Ser Trp Asp Asn Pro 
    210                 215                 220                 


Glu Glu Ala Leu Asn Asp Leu Met Asn Ala Leu Gln Glu Ala Ser Asn 
225                 230                 235                 240 


Ala Ser Ala Gly Pro Phe Gly Leu Ile Ile Asn Pro Lys Arg Tyr Ala 
                245                 250                 255     


Lys Leu Leu Lys Ile Tyr Glu Lys Ser Gly Lys Met Leu Val Glu Val 
            260                 265                 270         


Leu Lys Glu Ile Phe Arg Gly Gly Ile Ile Val Thr Leu Asn Ile Asp 
        275                 280                 285             


Glu Asn Lys Val Ile Ile Phe Ala Asn Thr Pro Ala Val Leu Asp Val 
    290                 295                 300                 


Val Val Gly Gln Asp Val Thr Leu Gln Glu Leu Gly Pro Glu Gly Asp 
305                 310                 315                 320 


Asp Val Ala Phe Leu Val Ser Glu Ala Ile Gly Ile Arg Ile Lys Asn 
                325                 330                 335     


Pro Glu Ala Ile Val Val Leu Glu 
            340                 


<210>  32
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  32

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gly 
            20                  


<210>  33
<211>  1254
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NivFtop_stab2_gMax_Nt_60mer

<400>  33
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagcatgcag       60

atctacgaag gaaaactgac cgctgaggga ctgaggttcg gaattgtcgc aagccgcgcg      120

aatcacgcac tggtggatag gctggtggaa ggcgctatcg acgcaattgt ccggcacggc      180

gggagagagg aagacatcac actggtgaga gtctgcggca gctgggagat tcccgtggca      240

gctggagaac tggctcgaaa ggaggacatc gatgccgtga tcgctattgg ggtcctgtgc      300

cgaggagcaa ctcccagctt cgactacatc gcctcagaag tgagcaaggg gctggctgat      360

ctgtccctgg agctgaggaa acctatcact tttggcgtga ttactgccga caccctggaa      420

caggcaatcg aggcggccgg cacctgccat ggaaacaaag gctgggaagc agccctgtgc      480

gctattgaga tggcaaatct gttcaaatct ctgcgaggag gctccggagg atctggaggg      540

agtggaggct caggaggagg cggggtcact tgtgccggac gagccatcgg aaatgctacc      600

gccgcccaga ttactgccgg agtcgccctg tatgaagcca tgaagaatgc cgacaacatc      660

aataagctga agagctccat cgagagcacc aacgaggccg tggtgaagct gcaggagaca      720

gccgagaaga cagtgtacgt gctgacagcc ctgcaggact atatcaacac caatctggtg      780

cccacaatcg ataagatcag ctgcaagcag accgaggcat ccctggacgc cgccctgtcc      840

aagtacctgt ctgatctgct gtacgtgttc ggccccaacc tgagcgaccc cgtgagcaat      900

tctatgccta tccaggccat ctctcaggcc ttcggcggca actacagcac cctgctgagg      960

acactgggct atgccccaga ggactttgac gatctgctgg agagcgattc catcacaggc     1020

cagatcatct acgtggacct gtctagctac tatatcatcg tgagagtgta ttttccaaat     1080

ggctccggcc ccctgaccaa ggatatcgtg atcaagatga tccccaacgt gtctaatatg     1140

agccagtgta caggctctgt gatggagaac tacaagacca ggctgaatgg catcctgaca     1200

cctatcaagg gcgccctgga gatctataag aataactgtc acgatggatg ataa           1254


<210>  34
<211>  693
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NivFtop_stab2_gMax

<400>  34
ggggtcactt gtgccggacg agccatcgga aatgctaccg ccgcccagat tactgccgga       60

gtcgccctgt atgaagccat gaagaatgcc gacaacatca ataagctgaa gagctccatc      120

gagagcacca acgaggccgt ggtgaagctg caggagacag ccgagaagac agtgtacgtg      180

ctgacagccc tgcaggacta tatcaacacc aatctggtgc ccacaatcga taagatcagc      240

tgcaagcaga ccgaggcatc cctggacgcc gccctgtcca agtacctgtc tgatctgctg      300

tacgtgttcg gccccaacct gagcgacccc gtgagcaatt ctatgcctat ccaggccatc      360

tctcaggcct tcggcggcaa ctacagcacc ctgctgagga cactgggcta tgccccagag      420

gactttgacg atctgctgga gagcgattcc atcacaggcc agatcatcta cgtggacctg      480

tctagctact atatcatcgt gagagtgtat tttccaaatg gctccggccc cctgaccaag      540

gatatcgtga tcaagatgat ccccaacgtg tctaatatga gccagtgtac aggctctgtg      600

atggagaact acaagaccag gctgaatggc atcctgacac ctatcaaggg cgccctggag      660

atctataaga ataactgtca cgatggatga taa                                   693


<210>  35
<211>  416
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgE-Self Assembly-Linker-Viral Antigen

<400>  35

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg 
            20                  25                  30          


Phe Gly Ile Val Ala Ser Arg Ala Asn His Ala Leu Val Asp Arg Leu 
        35                  40                  45              


Val Glu Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu 
    50                  55                  60                  


Asp Ile Thr Leu Val Arg Val Cys Gly Ser Trp Glu Ile Pro Val Ala 
65                  70                  75                  80  


Ala Gly Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile 
                85                  90                  95      


Gly Val Leu Cys Arg Gly Ala Thr Pro Ser Phe Asp Tyr Ile Ala Ser 
            100                 105                 110         


Glu Val Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro 
        115                 120                 125             


Ile Thr Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu 
    130                 135                 140                 


Ala Ala Gly Thr Cys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Cys 
145                 150                 155                 160 


Ala Ile Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Val Thr Cys Ala 
            180                 185                 190         


Gly Arg Ala Ile Gly Asn Ala Thr Ala Ala Gln Ile Thr Ala Gly Val 
        195                 200                 205             


Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile Asn Lys Leu Lys 
    210                 215                 220                 


Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys Leu Gln Glu Thr 
225                 230                 235                 240 


Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln Asp Tyr Ile Asn 
                245                 250                 255     


Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys Lys Gln Thr Glu 
            260                 265                 270         


Ala Ser Leu Asp Ala Ala Leu Ser Lys Tyr Leu Ser Asp Leu Leu Tyr 
        275                 280                 285             


Val Phe Gly Pro Asn Leu Ser Asp Pro Val Ser Asn Ser Met Pro Ile 
    290                 295                 300                 


Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Ser Thr Leu Leu Arg 
305                 310                 315                 320 


Thr Leu Gly Tyr Ala Pro Glu Asp Phe Asp Asp Leu Leu Glu Ser Asp 
                325                 330                 335     


Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser Ser Tyr Tyr Ile 
            340                 345                 350         


Ile Val Arg Val Tyr Phe Pro Asn Gly Ser Gly Pro Leu Thr Lys Asp 
        355                 360                 365             


Ile Val Ile Lys Met Ile Pro Asn Val Ser Asn Met Ser Gln Cys Thr 
    370                 375                 380                 


Gly Ser Val Met Glu Asn Tyr Lys Thr Arg Leu Asn Gly Ile Leu Thr 
385                 390                 395                 400 


Pro Ile Lys Gly Ala Leu Glu Ile Tyr Lys Asn Asn Cys His Asp Gly 
                405                 410                 415     


<210>  36
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NivFtop_stab2_gMax

<400>  36

Gly Val Thr Cys Ala Gly Arg Ala Ile Gly Asn Ala Thr Ala Ala Gln 
1               5                   10                  15      


Ile Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn 
            20                  25                  30          


Ile Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val 
        35                  40                  45              


Lys Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu 
    50                  55                  60                  


Gln Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser 
65                  70                  75                  80  


Cys Lys Gln Thr Glu Ala Ser Leu Asp Ala Ala Leu Ser Lys Tyr Leu 
                85                  90                  95      


Ser Asp Leu Leu Tyr Val Phe Gly Pro Asn Leu Ser Asp Pro Val Ser 
            100                 105                 110         


Asn Ser Met Pro Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Leu Gly Tyr Ala Pro Glu Asp Phe Asp Asp 
    130                 135                 140                 


Leu Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu 
145                 150                 155                 160 


Ser Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Asn Gly Ser Gly 
                165                 170                 175     


Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn Val Ser Asn 
            180                 185                 190         


Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys Thr Arg Leu 
        195                 200                 205             


Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile Tyr Lys Asn 
    210                 215                 220                 


Asn Cys His Asp Gly 
225                 


<210>  37
<211>  1254
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NivFtop_stab2_gMax_Ct_60mer

<400>  37
atggactgga cctggattct gttcctggtg gccgccgcca caagggtgca cagcggggtc       60

acttgtgccg gacgagccat cggaaatgct accgccgccc agattactgc cggagtcgcc      120

ctgtatgaag ccatgaagaa tgccgacaac atcaataagc tgaagagctc catcgagagc      180

accaacgagg ccgtggtgaa gctgcaggag acagccgaga agacagtgta cgtgctgaca      240

gccctgcagg actatatcaa caccaatctg gtgcccacaa tcgataagat cagctgcaag      300

cagaccgagg catccctgga cgccgccctg tccaagtacc tgtctgatct gctgtacgtg      360

ttcggcccca acctgagcga ccccgtgagc aattctatgc ctatccaggc catctctcag      420

gccttcggcg gcaactacag caccctgctg aggacactgg gctatgcccc agaggacttt      480

gacgatctgc tggagagcga ttccatcaca ggccagatca tctacgtgga cctgtctagc      540

tactatatca tcgtgagagt gtattttcca aatggctccg gccccctgac caaggatatc      600

gtgatcaaga tgatccccaa cgtgtctaat atgagccagt gtacaggctc tgtgatggag      660

aactacaaga ccaggctgaa tggcatcctg acacctatca agggcgccct ggagatctat      720

aagaataact gtcacgatgg aggaggctcc ggaggatctg gagggagtgg aggctcagga      780

ggaggcatgc agatctacga aggaaaactg accgctgagg gactgaggtt cggaattgtc      840

gcaagccgcg cgaatcacgc actggtggat aggctggtgg aaggcgctat cgacgcaatt      900

gtccggcacg gcgggagaga ggaagacatc acactggtga gagtctgcgg cagctgggag      960

attcccgtgg cagctggaga actggctcga aaggaggaca tcgatgccgt gatcgctatt     1020

ggggtcctgt gccgaggagc aactcccagc ttcgactaca tcgcctcaga agtgagcaag     1080

gggctggctg atctgtccct ggagctgagg aaacctatca cttttggcgt gattactgcc     1140

gacaccctgg aacaggcaat cgaggcggcc ggcacctgcc atggaaacaa aggctgggaa     1200

gcagccctgt gcgctattga gatggcaaat ctgttcaaat ctctgcgatg ataa           1254


<210>  38
<211>  416
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NivFtop_stab2_gMax_Ct_60mer

<400>  38

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Val Thr Cys Ala Gly Arg Ala Ile Gly Asn Ala Thr Ala 
            20                  25                  30          


Ala Gln Ile Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala 
        35                  40                  45              


Asp Asn Ile Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala 
    50                  55                  60                  


Val Val Lys Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr 
65                  70                  75                  80  


Ala Leu Gln Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys 
                85                  90                  95      


Ile Ser Cys Lys Gln Thr Glu Ala Ser Leu Asp Ala Ala Leu Ser Lys 
            100                 105                 110         


Tyr Leu Ser Asp Leu Leu Tyr Val Phe Gly Pro Asn Leu Ser Asp Pro 
        115                 120                 125             


Val Ser Asn Ser Met Pro Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly 
    130                 135                 140                 


Asn Tyr Ser Thr Leu Leu Arg Thr Leu Gly Tyr Ala Pro Glu Asp Phe 
145                 150                 155                 160 


Asp Asp Leu Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val 
                165                 170                 175     


Asp Leu Ser Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Asn Gly 
            180                 185                 190         


Ser Gly Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn Val 
        195                 200                 205             


Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys Thr 
    210                 215                 220                 


Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile Tyr 
225                 230                 235                 240 


Lys Asn Asn Cys His Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala 
            260                 265                 270         


Glu Gly Leu Arg Phe Gly Ile Val Ala Ser Arg Ala Asn His Ala Leu 
        275                 280                 285             


Val Asp Arg Leu Val Glu Gly Ala Ile Asp Ala Ile Val Arg His Gly 
    290                 295                 300                 


Gly Arg Glu Glu Asp Ile Thr Leu Val Arg Val Cys Gly Ser Trp Glu 
305                 310                 315                 320 


Ile Pro Val Ala Ala Gly Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala 
                325                 330                 335     


Val Ile Ala Ile Gly Val Leu Cys Arg Gly Ala Thr Pro Ser Phe Asp 
            340                 345                 350         


Tyr Ile Ala Ser Glu Val Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu 
        355                 360                 365             


Leu Arg Lys Pro Ile Thr Phe Gly Val Ile Thr Ala Asp Thr Leu Glu 
    370                 375                 380                 


Gln Ala Ile Glu Ala Ala Gly Thr Cys His Gly Asn Lys Gly Trp Glu 
385                 390                 395                 400 


Ala Ala Leu Cys Ala Ile Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
                405                 410                 415     


<210>  39
<211>  132
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader

<400>  39
atggactgga cctggagaat cctgttcctg gtggccgccg ccaccggcac acacgccgat       60

acacacttcc ccatctgcat cttttgctgt ggctgttgcc ataggtccaa gtgtgggatg      120

tgctgcaaaa ct                                                          132


<210>  40
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Leader

<400>  40

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  41
<211>  315
<212>  DNA
<213>  West Nile Virus

<400>  41
atgtctaaga aaccaggagg gcccggcaag agccgggctg tcaatatgct aaaacgcgga       60

atgccccgcg tgttgtcctt gattggactg aagagggcta tgttgaacct gatcgacggc      120

aaggggccaa tacgatttgt gttggctctc ttggcgttct tcaggttcac agcaattgct      180

ccgacccgag cagtgctgga tcgatggaga ggtgtgaaca aacaaacagc gatgaaacac      240

cttttgagtt ttaagaagga actagggacc ttgaccagtg ctatcaatcg gcggagctca      300

aaacaaaaga aaaga                                                       315


<210>  42
<211>  1518
<212>  DNA
<213>  Human papillomavirus

<400>  42
atgtcacttt ggcttccatc agaagctact gtttaccttc caccagttcc agtttcaaaa       60

gttgtttcaa ctgatgaata cgttgctagg actaatattt actaccatgc tggaacttca      120

aggcttcttg ctgttggaca tccatacttt ccaattaaaa aaccaaataa taataaaatt      180

cttgttccaa aagtttcagg acttcaatac agggttttta ggattcatct tccagatcca      240

aataaatttg gatttccaga tacttcattt tacaatccag atactcaaag gcttgtttgg      300

gcttgtgttg gagttgaagt tggaagggga caaccacttg gagttggaat ttcaggacat      360

ccacttctta ataaacttga tgatactgaa aatgcttcag cttacgctgc taatgctgga      420

gttgataata gggaatgtat ttcaatggat tacaaacaaa ctcaactttg tcttattgga      480

tgtaaaccac caattggaga acattgggga aaaggatcac catgtactaa tgttgctgtt      540

aatccaggag attgtccacc acttgaactt attaatactg ttattcaaga tggagatatg      600

gttgatactg gatttggagc tatggatttt actactcttc aagctaataa atcagaagtt      660

ccacttgata tctgtacttc aatttgtaaa tacccagatt acattaaaat ggtttcagaa      720

ccatacggag attcactttt tttttacctt aggagggaac aaatgtttgt taggcatctt      780

tttaataggg ctggagctgt tggagaaaat gttccagatg atctttacat taaaggatca      840

ggatcaactg ctaatcttgc ttcatcaaat tactttccaa ctccatcagg atcaatggtt      900

acttcagatg ctcaaatttt taataaacca tactggcttc aaagggctca aggacataat      960

aatggaattt gttggggaaa tcaacttttt gttactgttg ttgatactac taggtcaact     1020

aatatgtcac tttgtgctgc tatttcaact tcagaaacta cttacaaaaa tactaatttt     1080

aaagaatacc ttaggcatgg agaagaatac gatcttcaat ttatttttca actttgtaaa     1140

attactctta ctgctgatgt tatgacttac attcattcaa tgaattcaac tattcttgaa     1200

gattggaatt ttggacttca accaccacca ggaggaactc ttgaagatac ttacaggttt     1260

gttacttcac aagctattgc ttgtcaaaaa catactccac cagctccaaa agaggatcca     1320

cttaaaaaat acactttttg ggaagttaat cttaaagaaa aattttcagc agatcttgat     1380

caatttccac ttggaaggaa atttcttctt caagctggac ttaaagctaa accaaaattt     1440

actcttggaa aaaggaaagc tactccaact acttcatcaa cttcaactac tgctaaaagg     1500

aaaaaaagga aactttga                                                   1518


<210>  43
<211>  1422
<212>  DNA
<213>  Human papillomavirus

<400>  43
atgaggcaca agaggagcgc caagaggacc aagagggcca gcgccaccca gctgtacaag       60

acctgcaagc aggccggcac ctgccccccc gacatcatcc ccaaggtgga gggcaagacc      120

atcgccgacc agatcctgca gtacggcagc atgggcgtgt tcttcggcgg cctgggcatc      180

ggcaccggca gcggcaccgg cggcaggacc ggctacatcc ccctgggcac caggcccccc      240

accgccaccg acaccctggc ccccgtgagg ccccccctga ccgtggaccc cgtgggcccc      300

agcgacccca gcatcgtgag cctggtggag gagaccagct tcatcgacgc cggcgccccc      360

accagcgtgc ccagcatccc ccccgacgtg agcggcttca gcatcaccac cagcaccgac      420

accacccccg ccatcctgga catcaacaac accgtgacca ccgtgaccac ccacaacaac      480

cccaccttca ccgaccccag cgtgctgcag ccccccaccc ccgccgagac cggcggccac      540

ttcaccctga gcagcagcac catcagcacc cacaactacg aggagatccc catggacacc      600

ttcatcgtga gcaccaaccc caacaccgtg accagcagca cccccatccc cggcagcagg      660

cccgtggcca ggctgggcct gtacagcagg accacccagc aggtgaaggt ggtggacccc      720

gccttcgtga ccacccccac caagctgatc acctacgaca accccgccta cgagggcatc      780

gacgtggaca acaccctgta cttcagcagc aacgacaaca gcatcaacat cgcccccgac      840

cccgacttcc tggacatcgt ggccctgcac aggcccgccc tgaccagcag gaggaccggc      900

atcaggtaca gcaggatcgg caacaagcag accctgagga ccaggagcgg caagagcatc      960

ggcgccaagg tgcactacta ctacgacctg agcaccatcg accccgccga ggagatcgag     1020

ctgcagacca tcacccccag cacctacacc accaccagcc acgccgccag ccccaccagc     1080

atcaacaacg gcctgtacga catctacgcc gacgacttca tcaccgacac cagcaccacc     1140

cccgtgccca gcgtgcccag caccagcctg agcggctaca tccccgccaa caccaccatc     1200

cccttcggtg gcgcctacaa catccccctg gtgagcggcc ccgacatccc catcaacatc     1260

accgaccagg cccccagcct gatccccatc gtgcccggca gcccccagta caccatcatc     1320

gccgacgccg gcgacttcta cctgcacccc agctactaca tgctgaggaa gaggaggaag     1380

aggctgccct acttcttcag cgacgtgagc ctggccgcct ga                        1422


<210>  44
<211>  1725
<212>  DNA
<213>  Respiratory syncytial virus

<400>  44
gagctgccca tcctgaaaac aaacgccatc accaccatcc tggccgccgt gaccctgtgc       60

ttcgccagca gccagaacat caccgaggaa ttctaccaga gcacctgtag cgccgtgtcc      120

aagggctacc tgtctgccct gcggaccggc tggtacacca gcgtgatcac catcgagctg      180

agcaacatca aagaaaacaa gtgcaacggc accgacgcca aagtgaagct gatcaagcag      240

gaactggaca agtacaagaa cgccgtgacc gagctgcagc tgctgatgca gagcacccct      300

gccgccaaca acagagccag acgcgagctg ccccggttca tgaactacac cctgaacaac      360

accaagaaca ccaacgtgac cctgagcaag aagcggaagc ggcggttcct gggattcctg      420

ctgggcgtgg gcagcgccat tgcctctgga atcgctgtgt ctaaggtgct gcacctggaa      480

ggcgaagtga acaagatcaa gtccgccctg ctgagcacca acaaggccgt ggtgtccctg      540

agcaacggcg tgtccgtgct gaccagcaag gtgctggatc tgaagaacta catcgacaag      600

cagctgctgc ctatcgtgaa caagcagagc tgcagcatca gcaacatcga gacagtgatc      660

gagttccagc agaagaacaa ccggctgctg gaaatcaccc gcgagttcag cgtgaacgcc      720

ggcgtgacca cccccgtgtc cacctacatg ctgaccaaca gcgagctgct gagcctgatc      780

aacgacatgc ccatcaccaa cgaccagaaa aagctgatga gcaacaacgt gcagatcgtg      840

cggcagcaga gctactccat catgtccatc atcaaagaag aggtgctggc ctacgtggtg      900

cagctgcccc tgtacggcgt gatcgacacc ccctgctgga agctgcacac cagccccctg      960

tgcaccacca acaccaaaga gggcagcaac atctgcctga cccggaccga ccggggctgg     1020

tactgcgata atgccggcag cgtgtcattc tttccacagg ccgagacatg caaggtgcag     1080

agcaaccggg tgttctgcga caccatgaac agcctgaccc tgccctccga agtgaacctg     1140

tgcaacatcg acatcttcaa ccctaagtac gactgcaaga tcatgacctc caagaccgac     1200

gtgtccagct ccgtgatcac ctccctgggc gccatcgtgt cctgctacgg caagaccaag     1260

tgcaccgcca gcaacaagaa ccggggcatc atcaagacct tcagcaacgg ctgcgactac     1320

gtgtccaaca agggggtgga caccgtgtcc gtgggcaaca ccctgtacta cgtgaacaaa     1380

caggaaggca agagcctgta cgtgaagggc gagcccatca tcaacttcta cgaccccctg     1440

gtgttcccca gcgacgagtt cgacgccagc atcagccagg tgaacgagaa gatcaaccag     1500

agcctggcct tcatcagaaa gagcgacgag ctgctgcaca atgtgaatgc cggcaagagc     1560

accaccaata tcatgatcac cacaatcatc atcgtgatca ttgtgatcct gctgtccctg     1620

atcgccgtgg gcctgctgct gtactgcaag gcccggtcca cccctgtgac cctgtccaag     1680

gaccagctga gcggaatcat caacaatatc gccttctcca actga                     1725


<210>  45
<211>  479
<212>  PRT
<213>  Respiratory syncytial virus


<220>
<221>  misc_feature
<222>  (247)..(247)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (259)..(259)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (299)..(299)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
1               5                   10                  15      


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
            20                  25                  30          


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
        35                  40                  45              


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
    50                  55                  60                  


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
65                  70                  75                  80  


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
                85                  90                  95      


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
            100                 105                 110         


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
        115                 120                 125             


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
    130                 135                 140                 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
145                 150                 155                 160 


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
                165                 170                 175     


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
            180                 185                 190         


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
        195                 200                 205             


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
    210                 215                 220                 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
225                 230                 235                 240 


Thr Asp Arg Gly Trp Tyr Xaa Asp Asn Ala Gly Ser Val Ser Phe Phe 
                245                 250                 255     


Pro Gln Xaa Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
            260                 265                 270         


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile 
        275                 280                 285             


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Xaa Met Thr Ser Lys Thr 
    290                 295                 300                 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
305                 310                 315                 320 


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
                325                 330                 335     


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
            340                 345                 350         


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
        355                 360                 365             


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
    370                 375                 380                 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
385                 390                 395                 400 


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
                405                 410                 415     


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
            420                 425                 430         


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
        435                 440                 445             


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
    450                 455                 460                 


Lys Asp Gln Leu Ser Gly Ile Ile Asn Asn Ile Ala Phe Ser Asn 
465                 470                 475                 


<210>  46
<211>  897
<212>  DNA
<213>  Respiratory syncytial virus

<400>  46
atgtccaaga ataaggatca gaggaccgcg aaaacgcttg agaggacgtg ggacacgctg       60

aaccacctcc tgttcatctc ctcgtgtctc tacaagctca accttaagtc catcgcgcag      120

atcaccttga gcattctcgc catgatcatc tccaccagcc ttatcattgc cgcaatcatc      180

ttcatcgcat ccgccaacca taaggtgaca ttgactacag cgattatcca agacgctact      240

agccagatca agaataccac gccgacctat ttgacgcaaa atcctcagtt gggaattagc      300

ttctcgaatc tctcggaaac cacgtcgcag ccgactacaa ttcttgcgtc aacgactcca      360

tcggccaaat caacaccaca atcgactacc gtaaaaacga agaacacgac tacaacacag      420

attcagcctt caaagcccac gaccaaacag agacagaata agccgcccaa caagcccaac      480

aatgattttc acttcgaggt gtttaacttc gtgccctgtt cgatttgcag caataacccc      540

acgtgctggg cgatttgcaa gcgaatcccg aataagaagc ccgggaaaaa gaccacgacg      600

aaaccgacaa agaagccgac aatcaagaca acgaaaaagg atcttaaacc tcagacgaca      660

aagcctaagg aagtcttgac aacgaagcct acggaaaaac ccactatcaa tactaccaag      720

actaacatcc ggacaacact gctgacgagc aataccacgg gaaacccgga gctcacatcg      780

cagaaagaga cactccattc gacatcctcc gagggtaacc cttcgcccag ccaggtgtat      840

acgacgtcag aataccctag ccaaccctca tcgccctcaa atacgacccg gcaatga         897


<210>  47
<211>  298
<212>  PRT
<213>  Respiratory syncytial virus

<400>  47

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Arg Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Ser Asn Leu Ser Glu Thr Thr Ser Gln Pro Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Ser Ala Lys Ser Thr Pro Gln Ser 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Ile Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Ile 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Val Leu Thr Thr Lys Pro Thr Glu Lys Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Arg Thr Thr Leu Leu Thr Ser Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Glu Leu Thr Ser Gln Lys Glu Thr Leu His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Tyr Thr Thr Ser Glu Tyr Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Ser Asn Thr Thr Arg Gln 
    290                 295             


<210>  48
<211>  879
<212>  DNA
<213>  Respiratory syncytial virus


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (173)..(173)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (285)..(285)
<223>  n is a, c, g, or t

<400>  48
atgagcaaaa acaaaaacca aaggacggct cggacgnttg agaaaacatg ggacacgctt       60

aatcacctta ttgtgatctc atcgtgtttg taccggttga atctcaagag catcgcccag      120

attgcgctgt cagtcctggc catgattatc tcgacatcac tcatcatcgc agncatcatc      180

tttatcattt cagcgaatca caaggtaacg cttacaacag tcacggtgca gaccatcaag      240

aatcataccg aaaagaatat cacaacctac ctcacccaag tcagnccgga gagagtaagc      300

ccctcaaaac agcctactac gacacctccc atccacacga actcggcgac catctcaccg      360

aataccaaat cagaaacgca tcatacgacc gcacagacaa agggacgaac cactacaccc      420

acacagaaca acaaacccag caccaagccg aggccaaaga atccgcccaa gaagccgaaa      480

gatgactatc actttgaagt gttcaacttc gtaccgtgtt cgatttgcgg gaataatcag      540

ttgtgcaaat ccatttgcaa gacgatccca tccaacaaac cgaagaagaa acctaccatc      600

aagcccacaa acaagccaac gacaaaaaca acgaacaagc gcgatcccaa aacgctcgcg      660

aaaacgttga agaaggaaac gacgacaaac cctacgaaga aacccacgcc caagaccact      720

gagagagaca cctccacctc gcaatcgacg gtacttgaca cgactacgag caagcacact      780

atccagcaac agtccctgca ctcaaccacg cccgagaata caccaaactc aacacagact      840

ccgacagctt cagagccttc cacttcgaat tccacatga                             879


<210>  49
<211>  292
<212>  PRT
<213>  Respiratory syncytial virus


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Met Ser Lys Asn Lys Asn Gln Arg Thr Ala Arg Thr Xaa Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Xaa Asn His Leu Ile Val Ile Ser Ser Cys Leu Tyr Arg 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Ala Leu Ser Val Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Xaa Ile Ile Phe Ile Ile Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Val Thr Val Gln Thr Ile Lys 
65                  70                  75                  80  


Asn His Thr Glu Lys Asn Ile Thr Thr Tyr Leu Thr Gln Val Xaa Pro 
                85                  90                  95      


Glu Arg Val Ser Pro Ser Lys Gln Pro Thr Thr Thr Pro Pro Ile His 
            100                 105                 110         


Thr Asn Ser Ala Thr Ile Ser Pro Asn Thr Lys Ser Glu Thr His His 
        115                 120                 125             


Thr Thr Ala Gln Thr Lys Gly Arg Thr Thr Thr Pro Thr Gln Asn Asn 
    130                 135                 140                 


Lys Pro Ser Thr Lys Pro Arg Pro Lys Asn Pro Pro Lys Lys Pro Lys 
145                 150                 155                 160 


Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro Ser Asn 
            180                 185                 190         


Lys Pro Lys Lys Lys Pro Thr Ile Lys Pro Thr Asn Lys Pro Thr Thr 
        195                 200                 205             


Lys Thr Thr Asn Lys Arg Asp Pro Lys Thr Leu Ala Lys Thr Leu Lys 
    210                 215                 220                 


Lys Glu Thr Thr Thr Asn Pro Thr Lys Lys Pro Thr Pro Lys Thr Thr 
225                 230                 235                 240 


Glu Arg Asp Thr Ser Thr Ser Gln Ser Thr Val Leu Asp Thr Thr Thr 
                245                 250                 255     


Ser Lys His Thr Ile Gln Gln Gln Ser Leu His Ser Thr Thr Pro Glu 
            260                 265                 270         


Asn Thr Pro Asn Ser Thr Gln Thr Pro Thr Ala Ser Glu Pro Ser Thr 
        275                 280                 285             


Ser Asn Ser Thr 
    290         


<210>  50
<211>  2034
<212>  DNA
<213>  Zaire ebolavirus


<220>
<221>  misc_feature
<222>  (675)..(675)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1492)..(1492)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1752)..(1752)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1802)..(1802)
<223>  n is a, c, g, or t

<400>  50
atgggggtca ctgggattct gcagctgcct agagatcgct tcaagcgaac ctctttcttt       60

ctgtgggtca tcattctgtt ccagaggact tttagtatcc ctctgggcgt cattcacaat      120

tctaccctgc aggtgagtga cgtcgataag ctggtgtgtc gggacaaact gagctccacc      180

aaccagctga gatctgtcgg cctgaatctg gaggggaacg gagtggctac cgatgtccca      240

agtgcaacaa agagatgggg gtttcgctca ggagtgcccc ctaaagtggt caattacgag      300

gccggggaat gggctgagaa ttgctataac ctggaaatca agaaacccga cggatcagag      360

tgtctgccag ccgctcccga tgggattcgc ggattcccta gatgcagata cgtgcacaag      420

gtcagcggca ccgggccatg tgcaggagac ttcgcctttc ataaagaagg cgccttcttt      480

ctgtacgata gactggcttc caccgtgatc tataggggga ccacattcgc cgagggagtg      540

gtcgcttttc tgattctgcc tcaggccaag aaagacttct tttctagtca tcctctgcgg      600

gaaccagtga acgctaccga ggaccccagc agcggctact attccactac catcagatac      660

caggccacag gattnggcac caatgagaca gaatacctgt ttgaagtgga caacctgaca      720

tatgtccagc tggagtctag gttcactccc cagtttctgc tgcagctgaa tgaaactatc      780

tataccagtg gcaagcgctc aaatacaact gggaagctga tttggaaagt gaaccctgag      840

atcgatacca caattggcga atgggccttt tgggagacca agaaaaacct gacacggaag      900

atcagaagcg aggaactgtc cttcaccgca gtgagtaata gggccaaaaa catttcaggc      960

cagagcccag cacgaacttc ctctgacccc gggaccaata ctaccacaga agatcacaag     1020

atcatggcca gcgagaacag ttcagctatg gtgcaggtcc actcccaggg aagggaggca     1080

gccgtgtctc atctgactac cctggccaca atctctacta gtccccagag ccccacaact     1140

aagcccgggc ctgacaatag cacccataac acacctgtgt acaaactgga tatctccgaa     1200

gccacccagg tcgagcagca ccatcggaga acagacaatg attccactgc atctgacacc     1260

cctccagcaa ccacagctgc aggacccccc aaggctgaga atactaacac cagcaaaagc     1320

accgacctgc tggaccccgc aactaccaca tcaccacaga accacagcga gacagccggg     1380

aacaataaca ctcaccatca ggacaccgga gaggaatccg ccagctccgg caagctgggg     1440

ctgatcacaa atactattgc tggagtggca ggactgatca caggcgggag gngaactcga     1500

cgagaagcta ttgtgaacgc acagcccaaa tgcaatccta acctgcacta ttggactacc     1560

caggacgagg gagcagctat cggactggca tggattccat actttgggcc cgcagccgaa     1620

ggaatctata ccgagggcct gatgcataat caggatggac tgatctgtgg cctgcggcag     1680

ctggctaacg aaacaactca ggcactgcag ctgttcctgc gagctaccac agagctgcgg     1740

acctttagca tnctgaatcg caaggcaatt gacttcctgc tgcagcgatg gggaggcaca     1800

tnccacatcc tgggaccaga ctgctgtatt gagcctcatg attggacaaa gaacatcact     1860

gacaaaattg atcagatcat tcacgacttc gtggataaaa cactgccaga tcagggggac     1920

aatgataact ggtggactgg atggagacag tggattcccg ccggcattgg cgtcaccggc     1980

gtcattattg ccgtcattgc tctgttctgt atttgtaagt tcgtgttctg ataa           2034


<210>  51
<211>  676
<212>  PRT
<213>  Zaire ebolavirus


<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (498)..(498)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (584)..(584)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (601)..(601)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Xaa Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Pro Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Leu Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Xaa Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Xaa Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Xaa His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  52
<211>  2034
<212>  DNA
<213>  Sudan Ebolavirus


<220>
<221>  misc_feature
<222>  (202)..(202)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (422)..(422)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (510)..(510)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (720)..(720)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1042)..(1042)
<223>  n is a, c, g, or t

<400>  52
atggagggac tgtcactgct gcagctgcct agagataagt tcaggaaaag ctccttcttt       60

gtgtgggtca tcattctgtt ccagaaggcc ttttcaatgc ccctgggcgt ggtcactaat      120

agcaccctgg aagtgacaga gatcgatcag ctggtctgta aggaccacct ggcttcaact      180

gatcagctga aaagcgtggg gntgaacctg gagggatcag gcgtcagcac tgatattcct      240

tctgcaacca agagatgggg atttcgcagc ggagtgcccc ctaaagtggt ctcctacgaa      300

gcaggggagt gggccgaaaa ttgctataac ctggagatca agaaaccaga tggcagcgaa      360

tgtctgccac cccctccaga cggggtgcgc ggattcccca gatgcagata cgtccacaag      420

gnccagggga ccggaccttg tccaggagac tatgcctttc ataaagatgg cgctttcttt      480

ctgtacgacc gcctggctag tacagtgatn tatcgaggcg tcaatttcgc cgagggcgtg      540

atcgcttttc tgattctggc aaagccaaaa gaaaccttcc tgcagagccc tcccattagg      600

gaggccgtga actacacaga aaacacttct agttactacg ctacatccta cctggagtat      660

gaaatcgaga actttggcgc tcagcactct accacactgt tcaagattaa caataacacn      720

tttgtgctgc tggatcgccc tcatacacca cagttcctgt ttcagctgaa cgacactatc      780

cacctgcatc agcagctgag caatactacc ggaaaactga tttggacact ggacgctaat      840

atcaacgcag atattggcga gtgggccttc tgggaaaata agaaaaacct gtccgagcag      900

ctgcggggag aggaactgag ctttgaaaca ctgtccctga atgaaactga ggacgatgac      960

gccacctcaa gccgaacaac taagggccgg atctctgatc gggctaccag aaagtacagt     1020

gatctggtgc caaaagactc tnccggcatg gtgagtctgc acgtccctga aggggagacc     1080

acactgccat cccagaactc tactgagggc cggagagtgg acgtcaatac ccaggagact     1140

atcaccgaaa ctaccgcaac aatcattggc actaacggga ataacatgca gatcagcacc     1200

attggcacag ggctgtcctc tagtcagatt ctgtcaagct cccctaccat ggccccctcc     1260

cctgagacac agacttctac aacttataca cccaagctgc ctgtgatgac cacagaggaa     1320

cccactaccc cacccagaaa cagtcctggg tcaacaactg aggcacccac cctgaccaca     1380

cctgaaaata tcactaccgc cgtgaaaaca gtcctgcctc aggagtctac tagtaacgga     1440

ctgatcacca gcacagtgac tggaattctg ggcagtctgg ggctgcgcaa gcgatcaagg     1500

cgccaagtga atactcgggc taccggcaaa tgcaatccaa acctgcacta ctggaccgca     1560

caggagcagc ataacgccgc tgggatcgct tggattcctt acttcggacc aggcgcagag     1620

gggatctata ccgaaggact gatgcataat cagaacgccc tggtgtgtgg cctgagacag     1680

ctggcaaatg agacaactca ggccctgcag ctgttcctga gagcaaccac agaactgagg     1740

acctatacaa tcctgaaccg gaaggccatt gattttctgc tgcgacgatg gggcgggacc     1800

tgcagaatcc tgggaccaga ctgctgtatt gagccccacg attggaccaa gaacatcaca     1860

gacaagatca accagatcat tcatgatttc atcgacaacc cactgcccaa tcaggacaac     1920

gatgacaatt ggtggaccgg atggcgacag tggattcccg caggaattgg aatcaccgga     1980

attattattg ccattattgc tctgctgtgt gtctgtaagc tgctgtgttg ataa           2034


<210>  53
<211>  676
<212>  PRT
<213>  Sudan Ebolavirus


<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (141)..(141)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Met Glu Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Xaa Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Xaa Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Xaa Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asn Asn Asn Xaa 
225                 230                 235                 240 


Phe Val Leu Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Thr Leu Ser Leu Asn Glu Thr Glu Asp Asp Asp 
305                 310                 315                 320 


Ala Thr Ser Ser Arg Thr Thr Lys Gly Arg Ile Ser Asp Arg Ala Thr 
                325                 330                 335     


Arg Lys Tyr Ser Asp Leu Val Pro Lys Asp Ser Xaa Gly Met Val Ser 
            340                 345                 350         


Leu His Val Pro Glu Gly Glu Thr Thr Leu Pro Ser Gln Asn Ser Thr 
        355                 360                 365             


Glu Gly Arg Arg Val Asp Val Asn Thr Gln Glu Thr Ile Thr Glu Thr 
    370                 375                 380                 


Thr Ala Thr Ile Ile Gly Thr Asn Gly Asn Asn Met Gln Ile Ser Thr 
385                 390                 395                 400 


Ile Gly Thr Gly Leu Ser Ser Ser Gln Ile Leu Ser Ser Ser Pro Thr 
                405                 410                 415     


Met Ala Pro Ser Pro Glu Thr Gln Thr Ser Thr Thr Tyr Thr Pro Lys 
            420                 425                 430         


Leu Pro Val Met Thr Thr Glu Glu Pro Thr Thr Pro Pro Arg Asn Ser 
        435                 440                 445             


Pro Gly Ser Thr Thr Glu Ala Pro Thr Leu Thr Thr Pro Glu Asn Ile 
    450                 455                 460                 


Thr Thr Ala Val Lys Thr Val Leu Pro Gln Glu Ser Thr Ser Asn Gly 
465                 470                 475                 480 


Leu Ile Thr Ser Thr Val Thr Gly Ile Leu Gly Ser Leu Gly Leu Arg 
                485                 490                 495     


Lys Arg Ser Arg Arg Gln Val Asn Thr Arg Ala Thr Gly Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Gln Glu Gln His Asn Ala Ala Gly 
        515                 520                 525             


Ile Ala Trp Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Ala Leu Val Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Tyr Thr Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Arg Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Asn Pro Leu Pro Asn Gln Asp Asn 
625                 630                 635                 640 


Asp Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Ile Ile Ile Ala Ile Ile Ala Leu Leu Cys Val Cys 
            660                 665                 670         


Lys Leu Leu Cys 
        675     


<210>  54
<211>  2049
<212>  DNA
<213>  Marburgvirus


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  54
atgaaaacca cttgtctgct natctcactg attctgattc agggcgtcaa aacactgccc       60

attctggaaa ttgcctctaa catccagcca cagaacgtgg actccgtctg ttctgggacc      120

ctgcagaaga cagaggatgt gcacctgatg ggcttcaccc tgagcgggca gaaggtcgca      180

gactcacccc tggaagccag caaacgatgg gcatttcggg ccggagtgcc ccctaagaac      240

gtcgagtaca ccgaaggcga ggaagccaaa acatgctata atatctccgt gactgatcct      300

agtggcaagt cactgctgct ggacccaccc accaacatta gggattaccc taagtgtaaa      360

acaatccacc atattcaggg ccagaatcca cacgctcagg ggatcgcact gcatctgtgg      420

ggagccttct ttctgtacga caggattgct agcaccacaa tgtatcgcgg gaaagtgttc      480

accgagggaa acatcgccgc tatgattgtg aataagacag tccacaaaat gatcttttct      540

cgccagggcc aggggtaccg acatatgaac ctgaccagta caaataagta ttggaccagc      600

tccaacggca ctcagaccaa tgacactggg tgcttcggaa ccctgcagga gtacaacagt      660

actaaaaatc agacctgtgc tccatcaaag aaaccactgc cactgcctac cgcacaccca      720

gaggtgaagc tgacaagtac ttcaaccgac gccacaaaac tgaacactac cgaccccaat      780

agtgacgatg aagatctgac aactagcgga tccggctctg gggagcagga accttatacc      840

acatccgatg cagccaccaa gcagggcctg tctagtacaa tgcctccaac tccatctccc      900

cagcctagta ctccccagca gggcgggaac aataccaacc attcccaggg cgtggtcaca      960

gagccaggga agactaacac taccgcccag ccctctatgc cccctcacaa tacaactacc     1020

atctccacca acaatacatc taaacataac ctgagcacac cttccgtgcc aatccagaac     1080

gctactaact acaacactca gtctaccgca cccgagaatg aacagacttc tgcccctagt     1140

aagacaactc tgctgcccac cgagaaccct accacagcca agtcaacaaa tagcactaaa     1200

tcccctacta ccacagtgcc aaacactacc aataagtaca gtacctcacc aagccccacc     1260

cctaactcca cagcacagca cctggtctat ttccggagaa aaagaaatat cctgtggagg     1320

gagggcgaca tgttcccttt tctggatggg ctgatcaacg ctccaattga cttcgatcca     1380

gtgcccaata caaagactat ctttgacgaa tcaagctcct ctggcgcctc tgctgaggaa     1440

gatcagcacg cctcacccaa cattagcctg acactgtcct actttcctaa agtgaacgag     1500

aatactgccc atagcgggga gaacgaaaat gactgcgatg ctgagctgcg gatctggagc     1560

gtccaggaag acgatctggc tgcaggactg tcctggatcc cattctttgg acccggcatt     1620

gagggactgt ataccgccgg cctgattaag aaccagaaca acctggtgtg cagactgagg     1680

cgcctggcca atcagaccgc taaatcactg gaactgctgc tgcgggtcac aactgaggaa     1740

agaacattca gcctgatcaa ccgacatgct attgactttc tgctggcacg ctggggaggc     1800

acctgcaagg tgctgggacc agactgctgt atcggcattg aggatctgtc tcgcaatatc     1860

agtgaacaga tcgaccagat taagaaagat gagcagaagg aaggaaccgg atggggactg     1920

ggcggcaagt ggtggaccag cgattggggc gtgctgacaa acctgggaat cctgctgctg     1980

ctgtccatcg ccgtcctgat tgctctgtcc tgtatttgtc ggattttcac taagtatatt     2040

gggtgataa                                                             2049


<210>  55
<211>  681
<212>  PRT
<213>  Marburgvirus


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (200)..(200)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Met Lys Thr Thr Cys Leu Xaa Ile Ser Leu Ile Leu Ile Gln Gly Val 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Ile Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Ala Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Xaa Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Thr Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Lys Pro Leu Pro Leu Pro Thr Ala His Pro 
225                 230                 235                 240 


Glu Val Lys Leu Thr Ser Thr Ser Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Ala Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Gly Val Val Thr 
305                 310                 315                 320 


Glu Pro Gly Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Val Pro Ile Gln Asn Ala Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Pro Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Leu Pro Thr Glu Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Thr Val Pro Asn Thr Thr Asn Lys Tyr Ser Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Ser Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Asn Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Lys Val Asn Glu Asn Thr Ala His Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Ala Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  56
<211>  2999
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pVAX1 backbone sequence

<400>  56
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta      840

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca      900

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc      960

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     1020

gcaggcatgc tggggatgcg gtgggctcta tggcttctac tgggcggttt tatggacagc     1080

aagcgaaccg gaattgccag ctggggcgcc ctctggtaag gttgggaagc cctgcaaagt     1140

aaactggatg gctttctcgc cgccaaggat ctgatggcgc aggggatcaa gctctgatca     1200

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc     1260

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc     1320

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga     1380

cctgtccggt gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac     1440

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct     1500

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa     1560

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc     1620

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct     1680

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc     1740

caggctcaag gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg     1800

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct     1860

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct     1920

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca     1980

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga attattaacg cttacaattt     2040

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacaggtggc     2100

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     2160

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa     2220

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     2280

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     2340

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     2400

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     2460

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     2520

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     2580

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     2640

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     2700

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     2760

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     2820

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     2880

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     2940

agcaacgcgg cctttttacg gttcctgggc ttttgctggc cttttgctca catgttctt      2999


<210>  57
<211>  1221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NC99_60mer_pVax

<400>  57
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc cacaagggtg       60

cacagcatgc agatctacga aggaaaactg accgctgagg gactgaggtt cggaattgtc      120

gcaagccgcg cgaatcacgc actggtggat aggctggtgg aaggcgctat cgacgcaatt      180

gtccggcacg gcgggagaga ggaagacatc acactggtga gagtctgcgg cagctgggag      240

attcccgtgg cagctggaga actggctcga aaggaggaca tcgatgccgt gatcgctatt      300

ggggtcctgt gccgaggagc aactcccagc ttcgactaca tcgcctcaga agtgagcaag      360

gggctggctg atctgtccct ggagctgagg aaacctatca cttttggcgt gattactgcc      420

gacaccctgg aacaggcaat cgaggcggcc ggcacctgcc atggaaacaa aggctgggaa      480

gcagccctgt gcgctattga gatggcaaat ctgttcaaat ctctgcgagg aggctccgga      540

ggatctggag ggagtggagg ctcaggagga ggcgcccctc tgcagctggg aaactgctcc      600

gtggcaggat ggattctggg caatccagag tgtgagctgc tgatctctaa ggagtcctgg      660

tcttacatcg tggagacccc aaaccccgag aatggcacat gctttcccgg ctacttcgcc      720

gactatgagg agctgaggga gcagctgagc tccgtgtcta gcttcgagag atttgagatc      780

ttccctaagg agtcctcttg gccaaaccac accgtgacag gcgtgagcgc ctcctgttct      840

cacaacggca agagctcctt ttataggaat ctgctgtggc tgaccggcaa gaacggcctg      900

taccctaatc tgagcaagtc ctatgtgaac aataaggaga aggaggtgct ggtgctgtgg      960

ggcgtgcacc accctcccaa catcggcaat cagagggccc tgtaccacac cgagaacgcc     1020

tacgtgagcg tggtgtctag ccactacagc aggagattca cacccgagat cgccaagagg     1080

cctaaggtgc gcgaccagga gggacggatc aattactatt ggaccctgct ggagccaggc     1140

gatacaatca tctttgaggc caacggcaat ctgatcgccc cctggtatgc cttcgccctg     1200

tcccgcggct gataactcga g                                               1221


<210>  58
<211>  399
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NC99_60mer_pVax

<400>  58

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg 
            20                  25                  30          


Phe Gly Ile Val Ala Ser Arg Ala Asn His Ala Leu Val Asp Arg Leu 
        35                  40                  45              


Val Glu Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu 
    50                  55                  60                  


Asp Ile Thr Leu Val Arg Val Cys Gly Ser Trp Glu Ile Pro Val Ala 
65                  70                  75                  80  


Ala Gly Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile 
                85                  90                  95      


Gly Val Leu Cys Arg Gly Ala Thr Pro Ser Phe Asp Tyr Ile Ala Ser 
            100                 105                 110         


Glu Val Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro 
        115                 120                 125             


Ile Thr Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu 
    130                 135                 140                 


Ala Ala Gly Thr Cys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Cys 
145                 150                 155                 160 


Ala Ile Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ala Pro Leu Gln Leu 
            180                 185                 190         


Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu 
        195                 200                 205             


Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile Val Glu Thr Pro Asn 
    210                 215                 220                 


Pro Glu Asn Gly Thr Cys Phe Pro Gly Tyr Phe Ala Asp Tyr Glu Glu 
225                 230                 235                 240 


Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile 
                245                 250                 255     


Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr Val Thr Gly Val Ser 
            260                 265                 270         


Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe Tyr Arg Asn Leu Leu 
        275                 280                 285             


Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn Leu Ser Lys Ser Tyr 
    290                 295                 300                 


Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu Trp Gly Val His His 
305                 310                 315                 320 


Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr His Thr Glu Asn Ala 
                325                 330                 335     


Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg Arg Phe Thr Pro Glu 
            340                 345                 350         


Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Ile Asn Tyr 
        355                 360                 365             


Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile Ile Phe Glu Ala Asn 
    370                 375                 380                 


Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala Leu Ser Arg Gly 
385                 390                 395                 


<210>  59
<211>  1230
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NC99_g6_60mer_pVax

<400>  59
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc cacaagggtg       60

cacagcatgc agatctacga aggaaaactg accgctgagg gactgaggtt cggaattgtc      120

gcaagccgcg cgaatcacgc actggtggat aggctggtgg aaggcgctat cgacgcaatt      180

gtccggcacg gcgggagaga ggaagacatc acactggtga gagtctgcgg cagctgggag      240

attcccgtgg cagctggaga actggctcga aaggaggaca tcgatgccgt gatcgctatt      300

ggggtcctgt gccgaggagc aactcccagc ttcgactaca tcgcctcaga agtgagcaag      360

gggctggctg atctgtccct ggagctgagg aaacctatca cttttggcgt gattactgcc      420

gacaccctgg aacaggcaat cgaggcggcc ggcacctgcc atggaaacaa aggctgggaa      480

gcagccctgt gcgctattga gatggcaaat ctgttcaaat ctctgcgagg aggctccgga      540

ggatctggag ggagtggagg ctcaggagga ggcgcccctc tgcagctggg aaactgcagc      600

gtggcaggat ggattctggg caatccagag tgtgagctgc tgatctccaa ggagtcctgg      660

tcttacatcg tggagacccc aaaccccgag aatggcacat gctttcccgg caacttctct      720

gactatgagg agctgaggga gcagctgagc tccgtgtcta gcttcgagag atttgagatc      780

ttccctaagg agtcctcttg gccaaatcac accgtgacag gcgtgagcgc ctcctgttct      840

cacaacggca agagctcctt ttacaggaat ctgctgtggc tgaccggcaa gaacggcctg      900

taccctaatc tgagcaagtc ctataacaat acaaaggaga aggaggtgct ggtgctgtgg      960

ggcgtgcacc accctcccaa catcggcaat cagagggccc tgtaccacac cgagaacgcc     1020

tacgtgagcg tggtgtctag ccactactct aggagattca cacccaacat cagcaagagg     1080

cctaaggtgc gcgaccagga gggacggatc aattactatt ggaccctgct ggagccaggc     1140

gatacaatca tctttgaggc caacggcaat ctgatcgccc cctggtatgc cttcgccctg     1200

tctcgcggca acggcagctg ataactcgag                                      1230


<210>  60
<211>  402
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NC99_g6_60mer_pVax

<400>  60

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg 
            20                  25                  30          


Phe Gly Ile Val Ala Ser Arg Ala Asn His Ala Leu Val Asp Arg Leu 
        35                  40                  45              


Val Glu Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu 
    50                  55                  60                  


Asp Ile Thr Leu Val Arg Val Cys Gly Ser Trp Glu Ile Pro Val Ala 
65                  70                  75                  80  


Ala Gly Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile 
                85                  90                  95      


Gly Val Leu Cys Arg Gly Ala Thr Pro Ser Phe Asp Tyr Ile Ala Ser 
            100                 105                 110         


Glu Val Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro 
        115                 120                 125             


Ile Thr Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu 
    130                 135                 140                 


Ala Ala Gly Thr Cys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Cys 
145                 150                 155                 160 


Ala Ile Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ala Pro Leu Gln Leu 
            180                 185                 190         


Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu 
        195                 200                 205             


Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile Val Glu Thr Pro Asn 
    210                 215                 220                 


Pro Glu Asn Gly Thr Cys Phe Pro Gly Asn Phe Ser Asp Tyr Glu Glu 
225                 230                 235                 240 


Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile 
                245                 250                 255     


Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr Val Thr Gly Val Ser 
            260                 265                 270         


Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe Tyr Arg Asn Leu Leu 
        275                 280                 285             


Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn Leu Ser Lys Ser Tyr 
    290                 295                 300                 


Asn Asn Thr Lys Glu Lys Glu Val Leu Val Leu Trp Gly Val His His 
305                 310                 315                 320 


Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr His Thr Glu Asn Ala 
                325                 330                 335     


Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg Arg Phe Thr Pro Asn 
            340                 345                 350         


Ile Ser Lys Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Ile Asn Tyr 
        355                 360                 365             


Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile Ile Phe Glu Ala Asn 
    370                 375                 380                 


Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala Leu Ser Arg Gly Asn 
385                 390                 395                 400 


Gly Ser 
        


<210>  61
<211>  1227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CA09(175L)_Ferritin_pVax

<400>  61
atggactgga cttggattct gtttctggtc gccgctgcca ctcgcgtgca ttctgcccca       60

ctgcacctgg gcaagtgcaa catcgccggc tggattctgg gcaatcccga gtgtgagagc      120

ctgtccaccg ccagctcctg gagctacatc gtggagaccc cttctagcga caacggcaca      180

tgctttccag gcgacttcat cgattatgag gagctgaggg agcagctgtc ctctgtgagc      240

tccttcgaga gatttgagat cttccccaag acctctagct ggcctaacca cgattccaat      300

aagggagtga cagcagcatg tcctcacgca ggcgccaaga gcttttacaa gaacctgatc      360

tggctggtga agaagggcaa ttcctaccca aagctgtcta agagctatat caacgacaag      420

ggcaaggagg tgctggtgct gtggggcatc caccacccat ccacctctgc cgaccagcag      480

tctctgtacc agaatgccga tacatacgtg ttcgtgggct cctctcggta ctccaagaag      540

ttcaagccag agatcgccat caggcccaag gtgagagacc aggagggccg catgaattac      600

tattggacac tggtggagcc cggcgataag atcacctttg aggccacagg caacctggtg      660

gtgcctcggt atgccttcgc catggagcgc aatgcaagcg gggaaagcca ggtgcgacag      720

cagttctcca aagacatcga aaagctgctg aatgaacagg tcaacaagga aatgcagagc      780

agcaacctgt acatgtccat gagctcctgg tgctataccc actctctgga cggagcaggc      840

ctgttcctgt ttgatcacgc cgccgaggag tacgagcacg ccaagaagct gatcatcttc      900

ctgaatgaga acaatgtgcc cgtgcagctg acctctatca gcgcccctga gcacaagttc      960

gagggcctga cacagatctt tcagaaggcc tacgagcacg agcagcacat ctccgagtct     1020

atcaacaata tcgtggacca cgccatcaag tccaaggatc acgccacatt caactttctg     1080

cagtggtacg tggccgagca gcacgaggag gaggtgctgt ttaaggacat cctggataag     1140

atcgagctga tcggcaacga gaatcacggg ctgtatctgg ccgaccagta tgtgaagggc     1200

atcgctaaaa gcaggaaatc aggaagc                                         1227


<210>  62
<211>  409
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CA09(175L)_Ferritin_pVax

<400>  62

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile 
            20                  25                  30          


Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser 
        35                  40                  45              


Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Phe Pro Gly 
    50                  55                  60                  


Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser 
65                  70                  75                  80  


Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn 
                85                  90                  95      


His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala 
            100                 105                 110         


Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser 
        115                 120                 125             


Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val 
    130                 135                 140                 


Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln 
145                 150                 155                 160 


Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg 
                165                 170                 175     


Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg 
            180                 185                 190         


Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly 
        195                 200                 205             


Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr 
    210                 215                 220                 


Ala Phe Ala Met Glu Arg Asn Ala Ser Gly Glu Ser Gln Val Arg Gln 
225                 230                 235                 240 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
                245                 250                 255     


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
            260                 265                 270         


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
        275                 280                 285             


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
    290                 295                 300                 


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
305                 310                 315                 320 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
                325                 330                 335     


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
            340                 345                 350         


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
        355                 360                 365             


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
    370                 375                 380                 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
385                 390                 395                 400 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                405                 


<210>  63
<211>  2112
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H1_CA04/09_FL_HA_3BVE_pVAX

<400>  63
atggactgga cttggattct gttcctggtc gccgccgcaa cccgcgtgca ttctatgaag       60

gctattctgg tcgtgctgct gtatactttc gccaccgcca acgccgacac actgtgcatc      120

ggctaccacg ccaacaattc taccgacaca gtggataccg tgctggagaa gaatgtgacc      180

gtgacacaca gcgtgaacct gctggaggat aagcacaatg gcaagctgtg caagctgagg      240

ggagtggcac cactgcacct gggcaagtgc aacatcgccg gctggattct gggcaatccc      300

gagtgtgagt ccctgtctac agccagctcc tggtcctaca tcgtggagac accctctagc      360

gacaacggca catgctaccc tggcgacttt atcgattatg aggagctgcg ggagcagctg      420

agcagcgtga gcagcttcga gaggttcgag atcttcccca agacctctag ctggcctaac      480

cacgatagca ataagggagt gacagcagca tgtccacacg caggcgccaa gagcttctat      540

aagaacctga tctggctggt gaagaagggc aattcctacc ctaagctgag caagtcctat      600

atcaacgaca agggcaagga ggtgctggtg ctgtggggca tccaccaccc atctaccagc      660

gccgaccagc agtccctgta ccagaatgcc gatacatacg tgttcgtggg ctcctctcgg      720

tactctaaga agttcaagcc agagatcgcc atcaggccaa aggtgaggga ccaggaggga      780

cgcatgaact actattggac cctggtggag cccggcgata agatcacctt tgaggccaca      840

ggcaacctgg tggtgcctag atatgccttc gccatggaga gaaatgccgg ctccggcatc      900

atcatctctg acacccctgt gcacgattgc aacaccacat gtcagacccc aaagggcgcc      960

atcaacacat ccctgccttt tcagaatatc cacccaatca caatcggcaa gtgccctaag     1020

tacgtgaaga gcaccaagct gaggctggca acaggcctgc gcaatatccc atctatccag     1080

agcaggggcc tgtttggagc aatcgcaggc ttcatcgagg gaggatggac cggaatggtg     1140

gacggctggt acggctatca ccaccagaac gagcagggca gcggatatgc agcagacctg     1200

aagtccaccc agaatgccat cgatgagatc acaaacaagg tcaattccgt gatcgagaag     1260

atgaacaccc agtttacagc cgtgggcaag gagttcaatc acctggagaa gagaatcgag     1320

aacctgaata agaaggtgga cgatggcttc ctggacatct ggacctacaa cgccgagctg     1380

ctggtgctgc tggagaatga gaggacactg gactaccacg attccaacgt gaagaatctg     1440

tatgagaagg tgagatctca gctgaagaac aatgccaagg agatcggcaa cggctgcttc     1500

gagttttacc acaagtgcga caacacctgt atggagagcg tgaagaatgg cacatacgat     1560

tatcctaagt attccgagga ggccaagctg aaccgcgagg agatcgactc tggcggcgat     1620

atcatcaagc tgctgaacga gcaagtgaat aaggagatgc agagctccaa tctgtacatg     1680

tctatgtcta gctggtgtta tacccacagc ctggacggag caggcctgtt cctgtttgat     1740

cacgccgccg aggagtacga gcacgccaag aagctgatca tctttctgaa cgagaacaat     1800

gtgccagtgc agctgacctc catctctgcc cccgagcaca agtttgaggg cctgacacag     1860

atcttccaga aggcctacga gcacgagcag cacatcagcg agtccatcaa caatatcgtg     1920

gaccacgcca tcaagagcaa ggatcacgcc accttcaact ttctgcagtg gtacgtggcc     1980

gagcagcacg aggaggaggt gctgttcaag gacatcctgg ataagatcga gctgatcggc     2040

aacgagaatc acgggctgta cctggcagac cagtatgtca agggcatcgc aaagtcacgg     2100

aagagcggga gc                                                         2112


<210>  64
<211>  704
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H1_CA04/09_FL_HA_3BVE_pVAX

<400>  64

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr 
            20                  25                  30          


Ala Asn Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr 
        35                  40                  45              


Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
    50                  55                  60                  


Val Asn Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg 
65                  70                  75                  80  


Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile 
                85                  90                  95      


Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser 
            100                 105                 110         


Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly 
        115                 120                 125             


Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser 
    130                 135                 140                 


Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn 
145                 150                 155                 160 


His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala 
                165                 170                 175     


Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser 
            180                 185                 190         


Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val 
        195                 200                 205             


Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln 
    210                 215                 220                 


Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg 
225                 230                 235                 240 


Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg 
                245                 250                 255     


Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly 
            260                 265                 270         


Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr 
        275                 280                 285             


Ala Phe Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp 
    290                 295                 300                 


Thr Pro Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala 
305                 310                 315                 320 


Ile Asn Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly 
                325                 330                 335     


Lys Cys Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly 
            340                 345                 350         


Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr 
    370                 375                 380                 


Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser 
                405                 410                 415     


Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe 
            420                 425                 430         


Asn His Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp 
        435                 440                 445             


Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu 
    450                 455                 460                 


Glu Asn Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu 
465                 470                 475                 480 


Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu 
            500                 505                 510         


Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala 
        515                 520                 525             


Lys Leu Asn Arg Glu Glu Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu 
    530                 535                 540                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
545                 550                 555                 560 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                565                 570                 575     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            580                 585                 590         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        595                 600                 605             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    610                 615                 620                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
625                 630                 635                 640 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                645                 650                 655     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            660                 665                 670         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        675                 680                 685             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    690                 695                 700                 


<210>  65
<211>  327
<212>  PRT
<213>  Influenza A virus

<400>  65

Phe Thr Ala Thr Tyr Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn 
1               5                   10                  15      


Asn Ser Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val 
            20                  25                  30          


Thr His Ser Val Asn Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys 
        35                  40                  45              


Leu Leu Lys Gly Ile Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala 
    50                  55                  60                  


Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu 
65                  70                  75                  80  


Ser Trp Ser Tyr Ile Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys 
                85                  90                  95      


Tyr Pro Gly Tyr Phe Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser 
            100                 105                 110         


Ser Val Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser 
        115                 120                 125             


Trp Pro Asn His Thr Val Thr Gly Val Ser Ala Ser Cys Ser His Asn 
    130                 135                 140                 


Gly Lys Ser Ser Phe Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn 
145                 150                 155                 160 


Gly Leu Tyr Pro Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys 
                165                 170                 175     


Glu Val Leu Val Leu Trp Gly Val His His Pro Pro Asn Ile Gly Asn 
            180                 185                 190         


Gln Arg Ala Leu Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser 
        195                 200                 205             


Ser His Tyr Ser Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys 
    210                 215                 220                 


Val Arg Asp Gln Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu 
225                 230                 235                 240 


Pro Gly Asp Thr Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro 
                245                 250                 255     


Trp Tyr Ala Phe Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr 
            260                 265                 270         


Ser Asn Ala Pro Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln 
        275                 280                 285             


Gly Ala Ile Asn Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr 
    290                 295                 300                 


Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val 
305                 310                 315                 320 


Thr Gly Leu Arg Asn Ile His 
                325         


<210>  66
<211>  566
<212>  PRT
<213>  Influenza A virus

<400>  66

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  67
<211>  566
<212>  PRT
<213>  Influenza A virus

<400>  67

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


