                         SEQUENCE LISTING

<110>  NEURACLE SCIENCE CO., LTD.
       SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
 
<120>  ANTI-FAMILY WITH SEQUENCE SIMILARITY 19, MEMBER A5 ANTIBODIES AND
       METHOD OF USE THEREOF

<130>  3763.016PC02/C-K/DKC

<150>  US 62/787,711
<151>  2019-01-02

<150>  US 62/838,190
<151>  2019-04-24

<160>  137   

<170>  PatentIn version 3.5

<210>  1
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Ser Pro Arg Thr Gly Ser Arg Gln Asp Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ser Met Ser Ser Thr Phe Trp Ala Phe Met Ile Leu Ala Ser Leu 
            20                  25                  30          


Leu Ile Ala Tyr Cys Ser Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
        35                  40                  45              


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
    50                  55                  60                  


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
                85                  90                  95      


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
            100                 105                 110         


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
        115                 120                 125             


Thr Thr Val Ser 
    130         


<210>  2
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Leu Leu Lys Ala Leu Trp Ala Leu Ala Gly Ala Ala Leu Cys 
1               5                   10                  15      


Cys Phe Leu Val Leu Val Ile His Ala Gln Phe Leu Lys Glu Gly Gln 
            20                  25                  30          


Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu Asp Arg Asp Ser Ser 
        35                  40                  45              


Gln Pro Arg Arg Thr Ile Ala Arg Gln Thr Ala Arg Cys Ala Cys Arg 
    50                  55                  60                  


Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala Cys Val Asp 
65                  70                  75                  80  


Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu Pro Cys Leu 
                85                  90                  95      


Glu Gly Glu Gly Cys Asp Leu Leu Ile Asn Arg Ser Gly Trp Thr Cys 
            100                 105                 110         


Thr Gln Pro Gly Gly Arg Ile Lys Thr Thr Thr Val Ser 
        115                 120                 125 


<210>  3
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Tyr His His Arg Glu Trp Pro Ala Arg Ile Ile Lys Thr Lys Gln 
1               5                   10                  15      


Trp Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu 
            20                  25                  30          


Ile Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys 
        35                  40                  45              


Thr Thr Thr Val Ser 
    50              


<210>  4
<211>  1501
<212>  DNA
<213>  Homo sapiens

<400>  4
ggcggcggag gatggcgcgc gcggggcccg cacgtggagg ccggcgcggg ggcgcgggca       60

gggccggctg ctgagacgcg ctgctgcccc ccgcgcgggc gccgcggctt caatggcgcc      120

atcgcccagg accggcagcc ggcaagatgc gaccgccctg cccagcatgt cctcaacttt      180

ctgggcgttc atgatcctgg ccagcctgct catcgcctac tgcagtcagc tggccgccgg      240

cacctgtgag attgtgacct tggaccggga cagcagccag cctcggagga cgatcgcccg      300

gcagaccgcc cgctgtgcgt gtagaaaggg gcagatcgcc ggcaccacga gagcccggcc      360

cgcctgtgtg gacgcaagaa tcatcaagac caagcagtgg tgtgacatgc ttccgtgtct      420

ggagggggaa ggctgcgact tgttaatcaa ccggtcaggc tggacgtgca cgcagcccgg      480

cgggaggata aagaccacca cggtctcctg acaaacacag cccctgaggg ggccccggga      540

gtggccttgg ctccctggag agcccacgtc tcagccacag ttctccactc gcctcggact      600

tcacccgttc tctgccgccc gcccactccg tttccctgtg gtccgtgaag gacggcctca      660

ggccttggca tcctgagctt cggtctgtcc agccgacccg aggaggccgg actcagacac      720

ataggcgggg ggcggcacct ggcatcagca atacgcagtc tgtgggagcc cggccgcgcc      780

cagcccccgc cgaccgtggc gttggccctg ctgtcctcag aggaggagga ggaggaggca      840

gctccggcag ccacagaagg ctgcagccca gcccgcctga gacacgacgc ctgccccagg      900

ggactgtcag gcacagaagc ggcctcctcc cgtgccccag actgtccgaa ttgcttttat      960

tttcttatac tttcagtata ctccatagac caaagagcaa aatctatctg aacctggacg     1020

caccctcact gtcagggtcc ctggggtcgc ttgtgcgggc gggagggcaa tggtggcaga     1080

gacatgctgg tggccccggc ggagcggaga gggcggccgt ggtggaggcc tccaccccag     1140

gagcaccccg cacaccctcg gaggacgggc ttcggctgcg cggaggccgt ggcacacctg     1200

cgggaggcag cgacggcccc cacgcagacg ccgggaacgc aggccgcttt attcctctgt     1260

acttagatca acttgaccgt actaaaatcc ctttctgttt taaccagtta aacatgcctc     1320

ttctacagct ccatttttga tagttggata atccagtatc tgccaagagc atgttgggtc     1380

tcccgtgact gctgcctcat cgatacccca tttagctcca gaaagcaaag aaaactcgag     1440

taacacttgt ttgaaagaga tcattaaatg tattttgcaa agcccaaaaa aaaaaaaaaa     1500

a                                                                     1501


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1  - 3-2; 1-7A-IT Abs

<400>  5

Gly Phe Thr Phe Ser Ser Phe Asn Met Phe 
1               5                   10  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 - 3-2 Ab

<400>  6

Gln Ile Ser Ser Ser Gly Ser Ser Thr Asn Tyr Ala Pro Ala Val Arg 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3 - 3-2; 1-7A-IT; Low-PI; 1-30; 1-17; 1-32; 4-11; 
       6-10 Abs

<400>  7

Ser Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser 
1               5                   10                  15      


Ala Gly Glu Ile Asp Ala 
            20          


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 - 3-2; 1-7A-IT; 1-17; 1-32; 4-11; 6-10 Abs

<400>  8

Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly 
1               5                   10              


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 3-2 Ab

<400>  9

Glu Ser Asn Lys Arg Pro Ser 
1               5           


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 - 3-2; 1-7A-IT Abs

<400>  10

Gly Ser Trp Asp Ser Ser Asn Gly Gly Ile 
1               5                   10  


<210>  11
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH - 3-2 Ab

<400>  11

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gln Ile Ser Ser Ser Gly Ser Ser Thr Asn Tyr Ala Pro Ala Val 
    50                  55                  60                  


Arg Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Pro Gly Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val 
            100                 105                 110         


Asp Ser Ala Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 3-2 Ab

<400>  12

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 
        35                  40                  45              


Tyr Glu Ser Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Ile Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Asn Gly 
                85                  90                  95      


Gly Ile Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105             


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 - 1-7A-IT Ab

<400>  13

Gln Ile Ser Ser Ser Gly Ser Ser Thr Asn Tyr Ala Pro Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 - Low-PI; 1-30; 1-17; 1-32; 4-11; 6-10 Abs

<400>  14

Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 - Low-PI; 1-30; 1-17; 1-32; 4-11; 6-10 Abs

<400>  15

Gln Ile Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 - 2-13; 2-13D Abs

<400>  16

Gly Phe Thr Phe Ser Ser His Gly Met Phe 
1               5                   10  


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 - 2-13; 2-13D; 2-13D-37 Abs

<400>  17

Glu Ile Thr Asn Asp Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3 - 2-13;  2-13D; 2-13D-37 Abs

<400>  18

Ser Thr Tyr Glu Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly 
1               5                   10                  15      


Gln Ile Asp Ala 
            20  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 - 2-13D-37 Ab

<400>  19

Gly Phe Asp Phe Ser Ser His Gly Met Phe 
1               5                   10  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 1-7A-IT

<400>  20

Glu Asn Asn Lys Arg Pro Ser 
1               5           


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 - Low-PI; 1-30 Abs

<400>  21

Ser Gly Gly Gly Ser Glu Glu Glu Gln Tyr Tyr Tyr Gly 
1               5                   10              


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - Low-PI Ab

<400>  22

Glu Asp Glu Glu Arg Pro Ser 
1               5           


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 - Low-PI; 1-30; 1-17; 1-32 Abs

<400>  23

Gly Ser Trp Asp Ser Glu Asp Glu Asp His 
1               5                   10  


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 1-30; 1-32 Abs

<400>  24

Gln Asp Glu Glu Arg Pro Ser 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 1-17 Ab

<400>  25

Glu Asp Glu Gln Arg Pro Ser 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 4-11 Ab

<400>  26

Glu Asp His Glu Arg Pro Ser 
1               5           


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 - 4-11 Ab

<400>  27

Gly Ser Trp Asp Ser Ser Asp Glu Asp His 
1               5                   10  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 6-10 Ab

<400>  28

Gln Asp Leu Leu Arg Pro Ser 
1               5           


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 - 6-10 Ab

<400>  29

Gly Ser Trp Asp Ser Leu Ser Ser Ser His 
1               5                   10  


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 - 2-13 Ab

<400>  30

Ser Gly Gly Ser Tyr Ser Tyr Gly 
1               5               


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 - 2-13; 2-13D; 2-13D-37 Abs

<400>  31

Trp Asp Asp Glu Arg Pro Ser 
1               5           


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 - 2-13; 2-13D; 2-13D-37 Abs

<400>  32

Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val 
1               5                   10      


<210>  33
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH - 1-7A-IT Ab

<400>  33

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gln Ile Ser Ser Ser Gly Ser Ser Thr Asn Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val 
            100                 105                 110         


Asp Ser Ala Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  34
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH - Low-PI; 1-30; 1-17; 1-32; 4-11; 6-10 Abs

<400>  34

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gln Ile Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val 
            100                 105                 110         


Asp Ser Ala Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  35
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH - 2-13 Ab

<400>  35

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Glu Ile Thr Asn Asp Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Glu Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp 
            100                 105                 110         


Thr Gly Gln Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
        115                 120                 125             


Ser 
    


<210>  36
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH - 2-13D Ab

<400>  36

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Glu Ile Thr Asn Asp Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Glu Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp 
            100                 105                 110         


Thr Gly Gln Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
        115                 120                 125             


Ser 
    


<210>  37
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH - 2-13D-37 Ab

<400>  37

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Ser Ser His 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Glu Ile Thr Asn Asp Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Glu Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp 
            100                 105                 110         


Thr Gly Gln Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
        115                 120                 125             


Ser 
    


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 1-7A-IT Ab

<400>  38

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Asn Gly Gly 
                85                  90                  95      


Ile Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - Low-PI Ab

<400>  39

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Glu Glu Glu Gln Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asp Glu Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 1-30 Ab

<400>  40

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Glu Glu Glu Gln Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Gln Asp Glu Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 1-17 Ab

<400>  41

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asp Glu Gln Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 1-32 Ab

<400>  42

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Gln Asp Glu Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 4-11 Ab

<400>  43

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asp His Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 6-10 Ab

<400>  44

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Gln Asp Leu Leu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Leu Ser Ser Ser 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  45
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 2-13 Ab

<400>  45

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser 
    50                  55                  60                  


Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  46
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL - 2-13D; 2-13D-37 Abs

<400>  46

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu Arg 
        35                  40                  45              


Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser Thr 
    50                  55                  60                  


Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  47
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 3-2 Ab

<400>  47

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 
        35                  40                  45              


Tyr Glu Ser Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Ile Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Asn Gly 
                85                  90                  95      


Gly Ile Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser 
            100                 105                 110         


Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val 
        115                 120                 125             


Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu 
    130                 135                 140                 


Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Phe Asn Met 
145                 150                 155                 160 


Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ala Gln 
                165                 170                 175     


Ile Ser Ser Ser Gly Ser Ser Thr Asn Tyr Ala Pro Ala Val Arg Gly 
            180                 185                 190         


Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu Gln 
        195                 200                 205             


Leu Asn Asn Pro Gly Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Ser Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser 
225                 230                 235                 240 


Ala Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
                245                 250                 255     


Ser 
    


<210>  48
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFV - 1-7A-IT Ab

<400>  48

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Asn Gly Gly 
                85                  90                  95      


Ile Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Gly Ser Ser Thr Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  49
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - Low-PI Ab

<400>  49

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Glu Glu Glu Gln Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asp Glu Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  50
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 1-30 Ab

<400>  50

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Glu Glu Glu Gln Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Gln Asp Glu Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  51
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 1-17 Ab

<400>  51

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asp Glu Gln Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  52
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 1-32 Ab

<400>  52

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Gln Asp Glu Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Glu Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  53
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 4-11 Ab

<400>  53

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Glu Asp His Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Ser Asp Glu Asp 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  54
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 6-10 Ab

<400>  54

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr 
        35                  40                  45              


Gln Asp Leu Leu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ser Leu Ser Ser Ser 
                85                  90                  95      


His Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr 
        115                 120                 125             


Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Glu Ser Phe Asn Met Phe 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Gln Ile 
                165                 170                 175     


Ser Ser Ser Glu Glu Asp Glu Asn Tyr Ala Pro Ala Val Lys Gly Arg 
            180                 185                 190         


Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Ala Lys Ser 
    210                 215                 220                 


Ser Tyr Asp Cys Pro Tyr Gly His Cys Ser Ser Gly Val Asp Ser Ala 
225                 230                 235                 240 


Gly Glu Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250                 255     


<210>  55
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 2-13 Ab

<400>  55

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser 
    50                  55                  60                  


Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Ser Leu Val Cys 
    130                 135                 140                 


Lys Ala Ser Gly Phe Thr Phe Ser Ser His Gly Met Phe Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Gly Lys Gly Leu Glu Tyr Val Ala Glu Ile Thr Asn Asp 
                165                 170                 175     


Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val Lys Gly Arg Ala Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Gly Gln Ser Thr Val Arg Leu Gln Leu Asn Asn Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala Arg Ser Thr Tyr Glu 
    210                 215                 220                 


Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly Gln Ile Asp Ala 
225                 230                 235                 240 


Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250     


<210>  56
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 2-13D Ab

<400>  56

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu Arg 
        35                  40                  45              


Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser Thr 
    50                  55                  60                  


Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg Leu Ser Cys Ser 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Ser His Gly Met Phe Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Glu Ile Thr Asn Asp Gly 
                165                 170                 175     


Ser Gly Thr Asn Tyr Gly Ser Ala Val Lys Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala Arg Ser Thr Tyr Glu Cys 
    210                 215                 220                 


Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly Gln Ile Asp Ala Trp 
225                 230                 235                 240 


Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250 


<210>  57
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 2-13D-37 Ab

<400>  57

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu Arg 
        35                  40                  45              


Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser Thr 
    50                  55                  60                  


Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg Leu Ser Cys Ser 
    130                 135                 140                 


Ala Ser Gly Phe Asp Phe Ser Ser His Gly Met Phe Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Glu Ile Thr Asn Asp Gly 
                165                 170                 175     


Ser Gly Thr Asn Tyr Gly Ser Ala Val Lys Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala Arg Ser Thr Tyr Glu Cys 
    210                 215                 220                 


Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly Gln Ile Asp Ala Trp 
225                 230                 235                 240 


Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250 


<210>  58
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH -3-2 Ab

<400>  58
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctcagcctc       60

gtctgcaagg cctccgggtt caccttcagc agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtcgctcaa attagcagca gtggtagtag cacaaactac      180

gcacccgcgg tgaggggccg tgccaccatc tcgagggaca acgggcagag cacagtgagg      240

ctgcagctga acaaccccgg ggctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  59
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 1-7A-IT Ab

<400>  59
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctgggtt caccttcagc agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtggtagtag cacaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  60
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - Low-PI Ab

<400>  60
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctgggtt caccttcagc agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtggtagtag cacaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  61
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 1-30 Ab

<400>  61
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctggctt tgattttgaa agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtgaagaaga tgaaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  62
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 1-17 Ab

<400>  62
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctggctt tgattttgaa agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtgaagaaga tgaaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  63
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 1-32 Ab

<400>  63
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctggctt tgattttgaa agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtgaagaaga tgaaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  64
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 4-11 Ab

<400>  64
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctggctt tgattttgaa agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtgaagaaga tgaaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  65
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 6-10 Ab

<400>  65
gccgtgacgt tggatgaatc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

agctgcaagg cctctggctt tgattttgaa agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaata cgtctcgcag attagcagca gtgaagaaga tgaaaactac      180

gcacccgcgg tgaaaggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctgcg cgctgaagac accggcacct actactgcgc caaaagtagt      300

tatgactgtc cttacggtca ttgtagtagt ggtgttgata gtgctggtga gatcgacgca      360

tggggccacg ggaccgaagt catcgtctcc tcc                                   393


<210>  66
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 2-13 Ab

<400>  66
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctcagcctc       60

gtctgcaagg cctccgggtt caccttcagc agccatggca tgttctgggt gcgacagacg      120

cccggcaagg ggttggaata tgtcgctgaa attaccaatg atggtagtgg cacaaactac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacagtgagg      240

ctgcagctga acaacctcag ggctgaggac accggcacct acttctgcgc cagatctact      300

tatgaatgtc ctggtggttt tagttgttgg ggtgatactg gtcaaataga cgcatggggc      360

cacgggaccg aagtcatcgt ctcctcc                                          387


<210>  67
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 2-13D Ab

<400>  67
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctccgcctt       60

agctgcagcg cctccgggtt caccttcagc agccatggca tgttctgggt gcgacaggcg      120

cccggcaagg ggttggaata tgtctcggag attaccaatg atggtagtgg cacaaactac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctcag ggctgaggac accggcacct acttctgcgc cagatctact      300

tatgaatgtc ctggtggttt tagttgttgg ggtgatactg gtcaaataga cgcatggggc      360

cacgggaccg aagtcatcgt ctcctcc                                          387


<210>  68
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH - 2-13D-37 Ab

<400>  68
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctccgcctt       60

agctgcagcg cctccgggtt cgatttcagc agccatggca tgttctgggt gcgacaggcg      120

cccggcaagg ggttggaata tgtctcggag attaccaatg atggtagtgg cacaaactac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctcag ggctgaggac accggcacct acttctgcgc cagatctact      300

tatgaatgtc ctggtggttt tagttgttgg ggtgatactg gtcaaataga cgcatggggc      360

cacgggaccg aagtcatcgt ctcctcc                                          387


<210>  69
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL - 3-2 Ab

<400>  69
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtaccagca gaaggcacct      120

ggcagtgccc ctgtcactct gatctatgaa agcaacaaga gaccctcgga catcccttca      180

cgattctccg gttccacatc tggctccaca gccacactaa ccatcactgg ggtccaagcc      240

gatgacgagg ctatctatta ctgtgggagc tgggacagta gcaatggtgg tatatttggg      300

gccgggacaa ccctgaccgt ccta                                             324


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL - 1-7A-IT Ab

<400>  70
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatgaaaac aacaagagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtagca atggtggtat atttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  71
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL - Low-PI Ab

<400>  71
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatgaaaac aacaagagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtagca atggtggtat atttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  72
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL - 1-30 Ab

<400>  72
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagcgaaga agaacagtac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatcaggat gaagaaagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtgaag atgaagatca ttttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  73
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 1-17 Ab

<400>  73
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatgaagat gaacagagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtgaag atgaagatca ttttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  74
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 1-32 Ab

<400>  74
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatcaggat gaagaaagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtgaag atgaagatca ttttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  75
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 4-11 Ab

<400>  75
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatgaagac cacgagagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtagcg atgaagatca ttttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  76
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 6-10 Ab

<400>  76
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gcagctatgc tggaagttac tattatggct ggtatcagca gaagcctggc      120

agtgcccctg tcactctgat ctatcaggat ctgctgagac cctcggacat cccttcacga      180

ttctccggtt ccacatctgg ctccacagcc acactaacca tcactggggt ccaagccggc      240

gacgaggctg attattactg tgggagctgg gacagtctga gcagcagcca ttttggggcc      300

gggacaaccc tgaccgtcct a                                                321


<210>  77
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 2-13 Ab

<400>  77
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gataacctgc       60

tccgggggta gctatagcta tggctggttc cagcagaagt ctcctggcag tgcccttgtc      120

actgtgatct actgggatga tgagagaccc tcggacatcc cttcacgatt ctccggtgcc      180

ctatccggct ccacaaacac attaaccatc actggggtcc aagccgacga cgaggctgtc      240

tatttctgtg ggactgaaga catcagcggc actgctggtg tatttggggc cgggacaacc      300

ctgaccgtcc tg                                                          312


<210>  78
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 2-13D Ab

<400>  78
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgcgaa gataacctgc       60

tccgggggtg tgtatagcta tggctggttc cagcagaagc ctggcagtgc ccttgtcact      120

gtgatctact gggatgatga gagaccctcg gacatccctt cacgattctc cggtgcccta      180

tccggctcca caaacacatt aaccatcact ggggtccaag ccgaagacga ggctgattat      240

tattgtggga ctgaagacat cagcggcact gctggtgtat ttggggccgg gacaaccctg      300

accgtcctg                                                              309


<210>  79
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL 2-13D-37 Ab

<400>  79
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgcgaa gataacctgc       60

tccgggggtg tgtatagcta tggctggttc cagcagaagc ctggcagtgc ccttgtcact      120

gtgatctact gggatgatga gagaccctcg gacatccctt cacgattctc cggtgcccta      180

tccggctcca caaacacatt aaccatcact ggggtccaag ccgaagacga ggctgattat      240

tattgtggga ctgaagacat cagcggcact gctggtgtat ttggggccgg gacaaccctg      300

accgtcctg                                                              309


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 - 2-13D; 2-13D-37 Abs

<400>  80

Ser Gly Gly Val Tyr Ser Tyr Gly 
1               5               


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP1 Epitope

<400>  81

Ile Val Thr Leu Asp 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP2 Epitope

<400>  82

Asp Ser Ser Gln Pro 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP3 Epitope

<400>  83

Arg Thr Ile Ala Arg 
1               5   


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP4 Epitope

<400>  84

Ala Arg Cys Ala Cys Arg Lys 
1               5           


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP5 Epitope

<400>  85

Ala Arg Pro Ala 
1               


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP6 Epitope

<400>  86

Lys Thr Lys Gln Trp Cys Asp Met Leu 
1               5                   


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP7 Epitope

<400>  87

Gly Cys Asp Leu Leu Ile Asn Arg 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP8 Epitope

<400>  88

Thr Cys Thr Gln Pro Gly Gly Arg 
1               5               


<210>  89
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F1

<400>  89

Gln Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu Asp Arg 
1               5                   10                  


<210>  90
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F2

<400>  90

Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
1               5                   10                  15      


Thr Ala Arg Cys 
            20  


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F3

<400>  91

Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
1               5                   10                  15      


Ala Arg Pro Ala 
            20  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F4

<400>  92

Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
1               5                   10                  15      


Cys Asp Met Leu 
            20  


<210>  93
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F5

<400>  93

Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
1               5                   10                  15      


Asn Arg Ser Gly 
            20  


<210>  94
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F6

<400>  94

Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
1               5                   10                  15      


Thr Thr Val Ser 
            20  


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  95

Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  96
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-13 binding epitope 1

<400>  96

Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg 
1               5                   10              


<210>  97
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-13 binding epitope 2

<400>  97

Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
1               5                   10                  


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding epitope


<220>
<221>  BINDING
<222>  (1)..(2)
<223>  Antibody specifically binds to respective residue

<220>
<221>  BINDING
<222>  (6)..(8)
<223>  Antibody specifically binds to respective residue

<400>  98

Arg Asp Ser Ser Gln Pro Arg Arg 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding epitope


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  Antibody Specifically binds to respective residue

<220>
<221>  BINDING
<222>  (6)..(8)
<223>  Antibody Specifically binds to respective residue

<400>  99

Arg Asp Ser Ser Gln Pro Arg Arg 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding epitope


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  Antibody Specifically binds to respective residue

<220>
<221>  BINDING
<222>  (7)..(8)
<223>  Antibody Specifically binds to respective residue

<400>  100

Arg Asp Ser Ser Gln Pro Arg Arg 
1               5               


<210>  101
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature Human FAM19A5 Isoform 2

<400>  101

Gln Phe Leu Lys Glu Gly Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
1               5                   10                  15      


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
            20                  25                  30          


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
        35                  40                  45              


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
    50                  55                  60                  


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
65                  70                  75                  80  


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
                85                  90                  95      


Thr Thr Val Ser 
            100 


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #1 (residues 2-8 of SEQ ID NO: 101)

<400>  102

Phe Leu Lys Glu Gly Gln Leu 
1               5           


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #2 (residues 2-14 of SEQ ID NO: 101)

<400>  103

Phe Leu Lys Glu Gly Gln Leu Ala Ala Gly Thr Cys Glu 
1               5                   10              


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #3 (residues 3-11 of SEQ ID NO: 101)

<400>  104

Leu Lys Glu Gly Gln Leu Ala Ala Gly 
1               5                   


<210>  105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #4 (residues 3-15 of SEQ ID NO: 101)

<400>  105

Leu Lys Glu Gly Gln Leu Ala Ala Gly Thr Cys Glu Ile 
1               5                   10              


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #5 (residues 3-18 of SEQ ID NO: 101)

<400>  106

Leu Lys Glu Gly Gln Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu 
1               5                   10                  15      


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #6 (residues 9-15 of SEQ ID NO: 101)

<400>  107

Ala Ala Gly Thr Cys Glu Ile 
1               5           


<210>  108
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #7 (residues 20-38 of SEQ ID NO: 101)

<400>  108

Arg Asp Ser Ser Gln Pro Pro Arg Thr Ile Ala Arg Gln Thr Ala Arg 
1               5                   10                  15      


Cys Ala Cys 
            


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #8 (residues 24-34 of SEQ ID NO: 101)

<400>  109

Gln Pro Pro Arg Thr Ile Ala Arg Gln Thr Ala 
1               5                   10      


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #9 (residues 37-53 of SEQ ID NO: 101)

<400>  110

Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala 
1               5                   10                  15      


Cys 
    


<210>  111
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #10 (residues 37-55 of SEQ ID NO: 101)

<400>  111

Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala 
1               5                   10                  15      


Cys Val Asp 
            


<210>  112
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #12 (residues 56-65 of SEQ ID NO: 101)

<400>  112

Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala 
1               5                   10                  15      


Cys Val Asp Ala 
            20  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #12 (residues 56-65 of SEQ ID NO: 101)

<400>  113

Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys 
1               5                   10  


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #13 (residues 56-67 of SEQ ID NO: 101)

<400>  114

Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met 
1               5                   10          


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #14 (residues 56-68 of SEQ ID NO: 101)

<400>  115

Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu 
1               5                   10              


<210>  116
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #15 (residues 56-71 of SEQ ID NO: 101)

<400>  116

Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu Pro Cys Leu 
1               5                   10                  15      


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #16 (residues 57-67 of SEQ ID NO: 101)

<400>  117

Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met 
1               5                   10      


<210>  118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #17 (residues 57-68 of SEQ ID NO: 101)

<400>  118

Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu 
1               5                   10          


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #18 (residues 64-71 of SEQ ID NO: 101)

<400>  119

Trp Cys Asp Met Leu Pro Cys Leu 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #19 (residues 68-75 of SEQ ID NO: 101)

<400>  120

Leu Pro Cys Leu Glu Gly Glu Gly 
1               5               


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #20 (residues 69-75 of SEQ ID NO: 101)

<400>  121

Pro Cys Leu Glu Gly Glu Gly 
1               5           


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #21 (residues 69-77 of SEQ ID NO: 101)

<400>  122

Pro Cys Leu Glu Gly Glu Gly Cys Asp 
1               5                   


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #22 (residues 69-78 of SEQ ID NO: 101)

<400>  123

Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu 
1               5                   10  


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #23 (residues 72-78 of SEQ ID NO: 101)

<400>  124

Glu Gly Glu Gly Cys Asp Leu 
1               5           


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #24 (residues 72-79 of SEQ ID NO: 101)

<400>  125

Glu Gly Glu Gly Cys Asp Leu Leu 
1               5               


<210>  126
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #25 (residues 78-98 of SEQ ID NO: 101)

<400>  126

Leu Leu Ile Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg 
1               5                   10                  15      


Ile Lys Thr Thr Thr 
            20      


<210>  127
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Sequence #26 (residues 79-98 of SEQ ID NO: 101)

<400>  127

Leu Ile Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile 
1               5                   10                  15      


Lys Thr Thr Thr 
            20  


<210>  128
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-13D-37-1.5W-41 Ab VH-CDR3

<400>  128

Ser Ser Tyr Val Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly 
1               5                   10                  15      


Gln Ile Asp Ala 
            20  


<210>  129
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-13D-37-3W-16 Ab VH-CDR3

<400>  129

Ser Asn Tyr Ala Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly 
1               5                   10                  15      


Gln Ile Asp Ala 
            20  


<210>  130
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-13D-37-1.5W-41 Ab VH

<400>  130

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Ser Ser His 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Glu Ile Thr Asn Asp Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Tyr Val Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp 
            100                 105                 110         


Thr Gly Gln Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
        115                 120                 125             


Ser 
    


<210>  131
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-13D-37-3W-16 Ab VH

<400>  131

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Ser Ser His 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Glu Ile Thr Asn Asp Gly Ser Gly Thr Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Ala Cys Pro Gly Gly Phe Ser Cys Trp Gly Asp 
            100                 105                 110         


Thr Gly Gln Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
        115                 120                 125             


Ser 
    


<210>  132
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 2-13D-37-1.5W-41 Ab

<400>  132

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu Arg 
        35                  40                  45              


Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser Thr 
    50                  55                  60                  


Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg Leu Ser Cys Ser 
    130                 135                 140                 


Ala Ser Gly Phe Asp Phe Ser Ser His Gly Met Phe Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Glu Ile Thr Asn Asp Gly 
                165                 170                 175     


Ser Gly Thr Asn Tyr Gly Ser Ala Val Lys Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala Arg Ser Ser Tyr Val Cys 
    210                 215                 220                 


Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly Gln Ile Asp Ala Trp 
225                 230                 235                 240 


Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250 


<210>  133
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv - 2-13D-37-3W-16 Ab

<400>  133

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Trp Asp Asp Glu Arg 
        35                  40                  45              


Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ala Leu Ser Gly Ser Thr 
    50                  55                  60                  


Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gly Thr Glu Asp Ile Ser Gly Thr Ala Gly Val Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu Gly Gln Ser Ser Arg Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala Val Thr Leu Asp Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala Leu Arg Leu Ser Cys Ser 
    130                 135                 140                 


Ala Ser Gly Phe Asp Phe Ser Ser His Gly Met Phe Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Glu Ile Thr Asn Asp Gly 
                165                 170                 175     


Ser Gly Thr Asn Tyr Gly Ser Ala Val Lys Gly Arg Ala Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Gly Thr Tyr Phe Cys Ala Arg Ser Asn Tyr Ala Cys 
    210                 215                 220                 


Pro Gly Gly Phe Ser Cys Trp Gly Asp Thr Gly Gln Ile Asp Ala Trp 
225                 230                 235                 240 


Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250 


<210>  134
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-13D-37-1.5W-41 Ab VH

<400>  134
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctccgcctt       60

agctgcagcg cctccgggtt cgatttcagc agccatggca tgttctgggt gcgacaggcg      120

cccggcaagg ggttggaata tgtctcggag attaccaatg atggtagtgg cacaaactac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctcag ggctgaggac accggcacct acttctgcgc cagatcttct      300

tatgtttgtc ctggtggttt tagttgttgg ggtgatactg gtcaaataga cgcatggggc      360

cacgggaccg aagtcatcgt ctcctcc                                          387


<210>  135
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-13D-37-3W-16 Ab VH

<400>  135
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctccgcctt       60

agctgcagcg cctccgggtt cgatttcagc agccatggca tgttctgggt gcgacaggcg      120

cccggcaagg ggttggaata tgtctcggag attaccaatg atggtagtgg cacaaactac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtat      240

ctgcagatga acagcctcag ggctgaggac accggcacct acttctgcgc cagatctaat      300

tatgcttgtc ctggtggttt tagttgttgg ggtgatactg gtcaaataga cgcatggggc      360

cacgggaccg aagtcatcgt ctcctcc                                          387


<210>  136
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-13D-37-1.5W-41 Ab VL

<400>  136
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgcgaa gataacctgc       60

tccgggggtg tgtatagcta tggctggttc cagcagaagc ctggcagtgc ccttgtcact      120

gtgatctact gggatgatga gagaccctcg gacatccctt cacgattctc cggtgcccta      180

tccggctcca caaacacatt aaccatcact ggggtccaag ccgaagacga ggctgattat      240

tattgtggga ctgaagacat cagcggcact gctggtgtat ttggggccgg gacaaccctg      300

accgtcctg                                                              309


<210>  137
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-13D-37-3W-16 Ab VL

<400>  137
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgcgaa gataacctgc       60

tccgggggtg tgtatagcta tggctggttc cagcagaagc ctggcagtgc ccttgtcact      120

gtgatctact gggatgatga gagaccctcg gacatccctt cacgattctc cggtgcccta      180

tccggctcca caaacacatt aaccatcact ggggtccaag ccgaagacga ggctgattat      240

tattgtggga ctgaagacat cagcggcact gctggtgtat ttggggccgg gacaaccctg      300

accgtcctg                                                              309


