                               SEQUENCE LISTING

<110> ACTINIUM PHARMACEUTICALS, INC.
 
<120> METHODS FOR TREATING CANCER USING COMBINATIONS OF PARP 
      INHIBITORS AND ANTIBODY RADIOCONJUGATES 

<130> ACTINIUM-9PCT

<140> PCT/US2020/012016
<141> 2020-01-02

<150> 62/788,206
<151> 2019-01-04

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 1952
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
tctagaccac catggagaaa gacacactcc tgctatgggt cctacttctc tgggttccag       60

gttccacagg tgacattcag atgacccagt ctccgagctc tctgtccgca tcagtaggag      120

acagggtcac catcacatgc agagccagcg aaagtgtcga caattatggc attagcttta      180

tgaactggtt ccaacagaaa cccgggaagg ctcctaagct tctgatttac gctgcatcca      240

accaaggctc cggggtaccc tctcgcttct caggcagtgg atctgggaca gacttcactc      300

tcaccatttc atctctgcag cctgatgact tcgcaaccta ttactgtcag caaagtaagg      360

aggttccgtg gacgttcggt caagggacca aggtggagat caaacgtaag tagaatccaa      420

agtctagaaa ttctaaactc tgagggggtc ggatgacgtg gccattcttt gcctaaagca      480

ttgagtttac tgcaaggtca gaaaagcatg caaagccctc agaatggctg caaagagctc      540

caacaaaaca atttagaact ttattaagga atagggggaa gctaggaaga aactcaaaac      600

atcaagattt taaatacgct tcttggtctc cttgctataa ttatctggga taagcatgct      660

gttttctgtc tgtccctaac atgctctgtg attatccgca aacaacacac ccaagggcag      720

aactttgtta cttaaacacc atcctgtttg cttctttcct caggaactgt ggctgcacca      780

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg      840

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      900

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      960

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc     1020

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag     1080

tgttagaggg agaagtgccc ccacctgctc ctcagttcca gcctgacccc ctcccatcct     1140

ttggcctctg accctttttc cacaggggac ctacccctat tgcggtcctc cagctcatct     1200

ttcacctcac ccccctcctc ctccttggct ttaattatgc taatgttgga ggagaatgaa     1260

taaataaagt gaatctttgc acctgtggtt tctctctttc ctcatttaat aattattatc     1320

tgttgtttta ccaactactc aatttctctt ataagggact aaatatgtag tcatcctaag     1380

gcgcataacc atttataaaa atcatccttc attctatttt accctatcat cctctgcaag     1440

acagtcctcc ctcaaaccca caagccttct gtcctcacag tcccctgggc catggtagga     1500

gagacttgct tccttgtttt cccctcctca gcaagccctc atagtccttt ttaagggtga     1560

caggtcttac agtcatatat cctttgattc aattccctga gaatcaacca aagcaaattt     1620

ttcaaaagaa gaaacctgct ataaagagaa tcattcattg caacatgata taaaataaca     1680

acacaataaa agcaattaaa taaacaaaca atagggaaat gtttaagttc atcatggtac     1740

ttagacttaa tggaatgtca tgccttattt acatttttaa acaggtactg agggactcct     1800

gtctgccaag ggccgtattg agtactttcc acaacctaat ttaatccaca ctatactgtg     1860

agattaaaaa cattcattaa aatgttgcaa aggttctata aagctgagag acaaatatat     1920

tctataactc agcaatccca cttctaggat cc                                   1952


<210> 2
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210> 3
<211> 3246
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
tctagaccac catgggatgg agctggatct ttctcttcct cctgtcagga actgctggcg       60

tccactctca ggttcagctg gtgcagtctg gagctgaggt gaagaagcct gggagctcag      120

tgaaggtttc ctgcaaagct tctggctaca ccttcactga ctacaacatg cactgggtga      180

ggcaggctcc tggccaaggc ctggaatgga ttggatatat ttatccttac aatggtggta      240

ccggctacaa ccagaagttc aagagcaagg ccacaattac agcagacgag agtactaaca      300

cagcctacat ggaactctcc agcctgaggt ctgaggacac tgcagtctat tactgcgcaa      360

gagggcgccc cgctatggac tactggggcc aagggactct ggtcactgtc tcttcaggta      420

agaatggcct ctagaccacc atgggatgga gctttctggg gcaggccagg cctgaccttg      480

gctttggggc agggaggggg ctaaggtgag gcaggtggcg ccagccaggt gcacacccaa      540

tgcccatgag cccagacact ggacgctgaa cctcgcggac agttaagaac ccaggggcct      600

ctgcgccctg ggcccagctc tgtcccacac cgcggtcaca tggcaccacc tctcttgcag      660

cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg      720

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt      780

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag      840

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct      900

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttggtgaga      960

ggccagcaca gggagggagg gtgtctgctg gaagccaggc tcagcgctcc tgcctggacg     1020

catcccggct atgcagcccc agtccagggc agcaaggcag gccccgtctg cctcttcacc     1080

cggaggcctc tgcccgcccc actcatgctc agggagaggg tcttctggct ttttccccag     1140

gctctgggca ggcacaggct aggtgcccct aacccaggcc ctgcacacaa aggggcaggt     1200

gctgggctca gacctgccaa gagccatatc cgggaggacc ctgcccctga cctaagccca     1260

ccccaaaggc caaactctcc actccctcag ctcggacacc ttctctcctc ccagattcca     1320

gtaactccca atcttctctc tgcagagccc aaatcttgtg acaaaactca cacatgccca     1380

ccgtgcccag gtaagccagc ccaggcctcg ccctccagct caaggcggga caggtgccct     1440

agagtagcct gcatccaggg acaggcccca gccgggtgct gacacgtcca cctccatctc     1500

ttcctcagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa     1560

ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca     1620

cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa     1680

gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt     1740

cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct     1800

cccagccccc atcgagaaaa ccatctccaa agccaaaggt gggacccgtg gggtgcgagg     1860

gccacatgga cagaggccgg ctcggcccac cctctgccct gagagtgacc gctgtaccaa     1920

cctctgtccc tacagggcag ccccgagaac cacaggtgta caccctgccc ccatcccggg     1980

atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc tatcccagcg     2040

acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc     2100

ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg gacaagagca     2160

ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact     2220

acacgcagaa gagcctctcc ctgtctccgg gtaaatgagt gcgacggccg gcaagccccc     2280

gctccccggg ctctcgcggt cgcacgagga tgcttggcac gtaccccctg tacatacttc     2340

ccgggcgccc agcatggaaa taaagcaccc agcgctgccc tgggcccctg cgagactgtg     2400

atggttcttt ccacgggtca ggccgagtct gaggcctgag tggcatgagg gaggcagagc     2460

gggtcccact gtccccacac tggcccaggc tgtgcaggtg tgcctgggcc gcctagggtg     2520

gggctcagcc aggggctgcc ctcggcaggg tgggggattt gccagcgtgg ccctccctcc     2580

agcagcacct gccctgggct gggccacggg aagccctagg agcccctggg gacagacaca     2640

cagcccctgc ctctgtagga gactgtcctg ttctgtgagc gccctgtcct ccgacctcca     2700

tgcccactcg ggggcatgcc tagtccatgt gcgtagggac aggccctccc tcacccatct     2760

acccccacgg cactaacccc tggctgccct gcccagcctc gcacccgcat ggggacacaa     2820

ccgactccgg ggacatgcac tctcgggccc tgtggaggga ctggtgcaga tgcccacaca     2880

cacactcagc ccagacccgt tcaacaaacc ccgcactgag gttggccggc cacacggcca     2940

ccacacacac acgtgcacgc ctcacacacg gagcctcacc cgggcgaact gcacagcacc     3000

cagaccagag caaggtcctc gcacacgtga acactcctcg gacacaggcc cccacgagcc     3060

ccacgcggca cctcaaggcc cacgagcctc tcggcagctt ctccacatgc tgacctgctc     3120

agacaaaccc agccctcctc tcacaagggt gcccctgcag ccgccacaca cacacagggg     3180

atcacacacc acgtcacgtc cctggccctg gcccacttcc cagtgccgcc cttccctgca     3240

ggatcc                                                                3246


<210> 4
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


