                         SEQUENCE LISTING

<110>  ŵ˼＼ɷ޹˾
 
<120>  ˸ϸͻ弰Ӧ

<130>  IEC180227PCT

<150>  201910010091.X
<151>  2019-01-07

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
    450                 455                 460                 


Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 
465                 470                 475                 480 


Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
                485                 490                 495     


Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 
            500                 505                 510         


Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu 
        515                 520                 525             


Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu 
    530                 535                 540                 


Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 
545                 550                 555                 560 


Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 
                565                 570                 575     


Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 
            580                 585                 590         


Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 
        595                 600                 605             


Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 
    610                 615                 620                 


Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 
625                 630                 635                 640 


Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val 
                645                 650                 655     


Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 
            660                 665                 670         


Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 
        675                 680                 685             


Ile Leu Thr Tyr Lys Val Pro Gln Ser 
    690                 695         


<210>  2
<211>  697
<212>  PRT
<213>  artificial

<220>
<223>  130Arg-hHGFİ

<400>  2

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His Arg Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
    450                 455                 460                 


Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 
465                 470                 475                 480 


Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
                485                 490                 495     


Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 
            500                 505                 510         


Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu 
        515                 520                 525             


Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu 
    530                 535                 540                 


Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 
545                 550                 555                 560 


Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 
                565                 570                 575     


Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 
            580                 585                 590         


Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 
        595                 600                 605             


Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 
    610                 615                 620                 


Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 
625                 630                 635                 640 


Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val 
                645                 650                 655     


Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 
            660                 665                 670         


Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 
        675                 680                 685             


Ile Leu Thr Tyr Lys Val Pro Gln Ser 
    690                 695         


<210>  3
<211>  697
<212>  PRT
<213>  artificial

<220>
<223>  130His-hHGFİ

<400>  3

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His His Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
    450                 455                 460                 


Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 
465                 470                 475                 480 


Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
                485                 490                 495     


Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 
            500                 505                 510         


Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu 
        515                 520                 525             


Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu 
    530                 535                 540                 


Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 
545                 550                 555                 560 


Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 
                565                 570                 575     


Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 
            580                 585                 590         


Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 
        595                 600                 605             


Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 
    610                 615                 620                 


Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 
625                 630                 635                 640 


Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val 
                645                 650                 655     


Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 
            660                 665                 670         


Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 
        675                 680                 685             


Ile Leu Thr Tyr Lys Val Pro Gln Ser 
    690                 695         


<210>  4
<211>  697
<212>  PRT
<213>  artificial

<220>
<223>  130Lys-hHGFİ

<400>  4

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His Lys Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
    450                 455                 460                 


Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 
465                 470                 475                 480 


Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
                485                 490                 495     


Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 
            500                 505                 510         


Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu 
        515                 520                 525             


Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu 
    530                 535                 540                 


Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 
545                 550                 555                 560 


Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 
                565                 570                 575     


Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 
            580                 585                 590         


Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 
        595                 600                 605             


Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 
    610                 615                 620                 


Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 
625                 630                 635                 640 


Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val 
                645                 650                 655     


Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 
            660                 665                 670         


Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 
        675                 680                 685             


Ile Leu Thr Tyr Lys Val Pro Gln Ser 
    690                 695         


<210>  5
<211>  2094
<212>  DNA
<213>  Homo sapiens

<400>  5
caaaggaaaa gaagaaatac aattcatgaa ttcaaaaaat cagcaaagac taccctaatc       60

aaaatagatc cagcactgaa gataaaaacc aaaaaagtga atactgcaga ccaatgtgct      120

aatagatgta ctaggaataa aggacttcca ttcacttgca aggcttttgt ttttgataaa      180

gcaagaaaac aatgcctctg gttccccttc aatagcatgt caagtggagt gaaaaaagaa      240

tttggccatg aatttgacct ctatgaaaac aaagactaca ttagaaactg catcattggt      300

aaaggacgca gctacaaggg aacagtatct atcactaaga gtggcatcaa atgtcagccc      360

tggagttcca tgataccaca cgaacacagc tttttgcctt cgagctatcg gggtaaagac      420

ctacaggaaa actactgtcg aaatcctcga ggggaagaag ggggaccctg gtgtttcaca      480

agcaatccag aggtacgcta cgaagtctgt gacattcctc agtgttcaga agttgaatgc      540

atgacctgca atggggagag ttatcgaggt ctcatggatc atacagaatc aggcaagatt      600

tgtcagcgct gggatcatca gacaccacac cggcacaaat tcttgcctga aagatatccc      660

gacaagggct ttgatgataa ttattgccgc aatcccgatg gccagccgag gccatggtgc      720

tatactcttg accctcacac ccgctgggag tactgtgcaa ttaaaacatg cgctgacaat      780

actatgaatg acactgatgt tcctttggaa acaactgaat gcatccaagg tcaaggagaa      840

ggctacaggg gcactgtcaa taccatttgg aatggaattc catgtcagcg ttgggattct      900

cagtatcctc acgagcatga catgactcct gaaaatttca agtgcaagga cctacgagaa      960

aattactgcc gaaatccaga tgggtctgaa tcaccctggt gttttaccac tgatccaaac     1020

atccgagttg gctactgctc ccaaattcca aactgtgata tgtcacatgg acaagattgt     1080

tatcgtggga atggcaaaaa ttatatgggc aacttatccc aaacaagatc tggactaaca     1140

tgttcaatgt gggacaagaa catggaagac ttacatcgtc atatcttctg ggaaccagat     1200

gcaagtaagc tgaatgagaa ttactgccga aatccagatg atgatgctca tggaccctgg     1260

tgctacacgg gaaatccact cattccttgg gattattgcc ctatttctcg ttgtgaaggt     1320

gataccacac ctacaatagt caatttagac catcccgtaa tatcttgtgc caaaacgaaa     1380

caattgcgag ttgtaaatgg gattccaaca cgaacaaaca taggatggat ggttagtttg     1440

agatacagaa ataaacatat ctgcggagga tcattgataa aggagagttg ggttcttact     1500

gcacgacagt gtttcccttc tcgagacttg aaagattatg aagcttggct tggaattcat     1560

gatgtccacg gaagaggaga tgagaaatgc aaacaggttc tcaatgtttc ccagctggta     1620

tatggccctg aaggatcaga tctggtttta atgaagcttg ccaggcctgc tgtcctggat     1680

gattttgtta gtacgattga tttacctaat tatggatgca caattcctga aaagaccagt     1740

tgcagtgttt atggctgggg ctacactgga ttgatcaact atgatggcct attacgagtg     1800

gcacatctct atataatggg aaatgagaaa tgcagccagc atcatcgagg gaaggtgact     1860

ctgaatgagt ctgaaatatg tgctggggct gaaaagattg gatcaggacc atgtgagggg     1920

gattatggtg gcccacttgt ttgtgagcaa cataaaatga gaatggttct tggtgtcatt     1980

gttcctggtc gtggatgtgc cattccaaat cgtcctggta tttttgtccg agtagcatat     2040

tatgcaaaat ggatacacaa aattatttta acatataagg taccacagtc atag           2094


<210>  6
<211>  2094
<212>  DNA
<213>  artificial

<220>
<223>  130Arg-hHGFĺ

<400>  6
caaaggaaaa gaagaaatac aattcatgaa ttcaaaaaat cagcaaagac taccctaatc       60

aaaatagatc cagcactgaa gataaaaacc aaaaaagtga atactgcaga ccaatgtgct      120

aatagatgta ctaggaataa aggacttcca ttcacttgca aggcttttgt ttttgataaa      180

gcaagaaaac aatgcctctg gttccccttc aatagcatgt caagtggagt gaaaaaagaa      240

tttggccatg aatttgacct ctatgaaaac aaagactaca ttagaaactg catcattggt      300

aaaggacgca gctacaaggg aacagtatct atcactaaga gtggcatcaa atgtcagccc      360

tggagttcca tgataccaca cgaacacaga tttttgcctt cgagctatcg gggtaaagac      420

ctacaggaaa actactgtcg aaatcctcga ggggaagaag ggggaccctg gtgtttcaca      480

agcaatccag aggtacgcta cgaagtctgt gacattcctc agtgttcaga agttgaatgc      540

atgacctgca atggggagag ttatcgaggt ctcatggatc atacagaatc aggcaagatt      600

tgtcagcgct gggatcatca gacaccacac cggcacaaat tcttgcctga aagatatccc      660

gacaagggct ttgatgataa ttattgccgc aatcccgatg gccagccgag gccatggtgc      720

tatactcttg accctcacac ccgctgggag tactgtgcaa ttaaaacatg cgctgacaat      780

actatgaatg acactgatgt tcctttggaa acaactgaat gcatccaagg tcaaggagaa      840

ggctacaggg gcactgtcaa taccatttgg aatggaattc catgtcagcg ttgggattct      900

cagtatcctc acgagcatga catgactcct gaaaatttca agtgcaagga cctacgagaa      960

aattactgcc gaaatccaga tgggtctgaa tcaccctggt gttttaccac tgatccaaac     1020

atccgagttg gctactgctc ccaaattcca aactgtgata tgtcacatgg acaagattgt     1080

tatcgtggga atggcaaaaa ttatatgggc aacttatccc aaacaagatc tggactaaca     1140

tgttcaatgt gggacaagaa catggaagac ttacatcgtc atatcttctg ggaaccagat     1200

gcaagtaagc tgaatgagaa ttactgccga aatccagatg atgatgctca tggaccctgg     1260

tgctacacgg gaaatccact cattccttgg gattattgcc ctatttctcg ttgtgaaggt     1320

gataccacac ctacaatagt caatttagac catcccgtaa tatcttgtgc caaaacgaaa     1380

caattgcgag ttgtaaatgg gattccaaca cgaacaaaca taggatggat ggttagtttg     1440

agatacagaa ataaacatat ctgcggagga tcattgataa aggagagttg ggttcttact     1500

gcacgacagt gtttcccttc tcgagacttg aaagattatg aagcttggct tggaattcat     1560

gatgtccacg gaagaggaga tgagaaatgc aaacaggttc tcaatgtttc ccagctggta     1620

tatggccctg aaggatcaga tctggtttta atgaagcttg ccaggcctgc tgtcctggat     1680

gattttgtta gtacgattga tttacctaat tatggatgca caattcctga aaagaccagt     1740

tgcagtgttt atggctgggg ctacactgga ttgatcaact atgatggcct attacgagtg     1800

gcacatctct atataatggg aaatgagaaa tgcagccagc atcatcgagg gaaggtgact     1860

ctgaatgagt ctgaaatatg tgctggggct gaaaagattg gatcaggacc atgtgagggg     1920

gattatggtg gcccacttgt ttgtgagcaa cataaaatga gaatggttct tggtgtcatt     1980

gttcctggtc gtggatgtgc cattccaaat cgtcctggta tttttgtccg agtagcatat     2040

tatgcaaaat ggatacacaa aattatttta acatataagg taccacagtc atag           2094


<210>  7
<211>  2094
<212>  DNA
<213>  artificial

<220>
<223>  130His-hHGFĺ

<400>  7
caaaggaaaa gaagaaatac aattcatgaa ttcaaaaaat cagcaaagac taccctaatc       60

aaaatagatc cagcactgaa gataaaaacc aaaaaagtga atactgcaga ccaatgtgct      120

aatagatgta ctaggaataa aggacttcca ttcacttgca aggcttttgt ttttgataaa      180

gcaagaaaac aatgcctctg gttccccttc aatagcatgt caagtggagt gaaaaaagaa      240

tttggccatg aatttgacct ctatgaaaac aaagactaca ttagaaactg catcattggt      300

aaaggacgca gctacaaggg aacagtatct atcactaaga gtggcatcaa atgtcagccc      360

tggagttcca tgataccaca cgaacaccac tttttgcctt cgagctatcg gggtaaagac      420

ctacaggaaa actactgtcg aaatcctcga ggggaagaag ggggaccctg gtgtttcaca      480

agcaatccag aggtacgcta cgaagtctgt gacattcctc agtgttcaga agttgaatgc      540

atgacctgca atggggagag ttatcgaggt ctcatggatc atacagaatc aggcaagatt      600

tgtcagcgct gggatcatca gacaccacac cggcacaaat tcttgcctga aagatatccc      660

gacaagggct ttgatgataa ttattgccgc aatcccgatg gccagccgag gccatggtgc      720

tatactcttg accctcacac ccgctgggag tactgtgcaa ttaaaacatg cgctgacaat      780

actatgaatg acactgatgt tcctttggaa acaactgaat gcatccaagg tcaaggagaa      840

ggctacaggg gcactgtcaa taccatttgg aatggaattc catgtcagcg ttgggattct      900

cagtatcctc acgagcatga catgactcct gaaaatttca agtgcaagga cctacgagaa      960

aattactgcc gaaatccaga tgggtctgaa tcaccctggt gttttaccac tgatccaaac     1020

atccgagttg gctactgctc ccaaattcca aactgtgata tgtcacatgg acaagattgt     1080

tatcgtggga atggcaaaaa ttatatgggc aacttatccc aaacaagatc tggactaaca     1140

tgttcaatgt gggacaagaa catggaagac ttacatcgtc atatcttctg ggaaccagat     1200

gcaagtaagc tgaatgagaa ttactgccga aatccagatg atgatgctca tggaccctgg     1260

tgctacacgg gaaatccact cattccttgg gattattgcc ctatttctcg ttgtgaaggt     1320

gataccacac ctacaatagt caatttagac catcccgtaa tatcttgtgc caaaacgaaa     1380

caattgcgag ttgtaaatgg gattccaaca cgaacaaaca taggatggat ggttagtttg     1440

agatacagaa ataaacatat ctgcggagga tcattgataa aggagagttg ggttcttact     1500

gcacgacagt gtttcccttc tcgagacttg aaagattatg aagcttggct tggaattcat     1560

gatgtccacg gaagaggaga tgagaaatgc aaacaggttc tcaatgtttc ccagctggta     1620

tatggccctg aaggatcaga tctggtttta atgaagcttg ccaggcctgc tgtcctggat     1680

gattttgtta gtacgattga tttacctaat tatggatgca caattcctga aaagaccagt     1740

tgcagtgttt atggctgggg ctacactgga ttgatcaact atgatggcct attacgagtg     1800

gcacatctct atataatggg aaatgagaaa tgcagccagc atcatcgagg gaaggtgact     1860

ctgaatgagt ctgaaatatg tgctggggct gaaaagattg gatcaggacc atgtgagggg     1920

gattatggtg gcccacttgt ttgtgagcaa cataaaatga gaatggttct tggtgtcatt     1980

gttcctggtc gtggatgtgc cattccaaat cgtcctggta tttttgtccg agtagcatat     2040

tatgcaaaat ggatacacaa aattatttta acatataagg taccacagtc atag           2094


<210>  8
<211>  2094
<212>  DNA
<213>  artificial

<220>
<223>  130Lys-hHGFĺ

<400>  8
caaaggaaaa gaagaaatac aattcatgaa ttcaaaaaat cagcaaagac taccctaatc       60

aaaatagatc cagcactgaa gataaaaacc aaaaaagtga atactgcaga ccaatgtgct      120

aatagatgta ctaggaataa aggacttcca ttcacttgca aggcttttgt ttttgataaa      180

gcaagaaaac aatgcctctg gttccccttc aatagcatgt caagtggagt gaaaaaagaa      240

tttggccatg aatttgacct ctatgaaaac aaagactaca ttagaaactg catcattggt      300

aaaggacgca gctacaaggg aacagtatct atcactaaga gtggcatcaa atgtcagccc      360

tggagttcca tgataccaca cgaacacaag tttttgcctt cgagctatcg gggtaaagac      420

ctacaggaaa actactgtcg aaatcctcga ggggaagaag ggggaccctg gtgtttcaca      480

agcaatccag aggtacgcta cgaagtctgt gacattcctc agtgttcaga agttgaatgc      540

atgacctgca atggggagag ttatcgaggt ctcatggatc atacagaatc aggcaagatt      600

tgtcagcgct gggatcatca gacaccacac cggcacaaat tcttgcctga aagatatccc      660

gacaagggct ttgatgataa ttattgccgc aatcccgatg gccagccgag gccatggtgc      720

tatactcttg accctcacac ccgctgggag tactgtgcaa ttaaaacatg cgctgacaat      780

actatgaatg acactgatgt tcctttggaa acaactgaat gcatccaagg tcaaggagaa      840

ggctacaggg gcactgtcaa taccatttgg aatggaattc catgtcagcg ttgggattct      900

cagtatcctc acgagcatga catgactcct gaaaatttca agtgcaagga cctacgagaa      960

aattactgcc gaaatccaga tgggtctgaa tcaccctggt gttttaccac tgatccaaac     1020

atccgagttg gctactgctc ccaaattcca aactgtgata tgtcacatgg acaagattgt     1080

tatcgtggga atggcaaaaa ttatatgggc aacttatccc aaacaagatc tggactaaca     1140

tgttcaatgt gggacaagaa catggaagac ttacatcgtc atatcttctg ggaaccagat     1200

gcaagtaagc tgaatgagaa ttactgccga aatccagatg atgatgctca tggaccctgg     1260

tgctacacgg gaaatccact cattccttgg gattattgcc ctatttctcg ttgtgaaggt     1320

gataccacac ctacaatagt caatttagac catcccgtaa tatcttgtgc caaaacgaaa     1380

caattgcgag ttgtaaatgg gattccaaca cgaacaaaca taggatggat ggttagtttg     1440

agatacagaa ataaacatat ctgcggagga tcattgataa aggagagttg ggttcttact     1500

gcacgacagt gtttcccttc tcgagacttg aaagattatg aagcttggct tggaattcat     1560

gatgtccacg gaagaggaga tgagaaatgc aaacaggttc tcaatgtttc ccagctggta     1620

tatggccctg aaggatcaga tctggtttta atgaagcttg ccaggcctgc tgtcctggat     1680

gattttgtta gtacgattga tttacctaat tatggatgca caattcctga aaagaccagt     1740

tgcagtgttt atggctgggg ctacactgga ttgatcaact atgatggcct attacgagtg     1800

gcacatctct atataatggg aaatgagaaa tgcagccagc atcatcgagg gaaggtgact     1860

ctgaatgagt ctgaaatatg tgctggggct gaaaagattg gatcaggacc atgtgagggg     1920

gattatggtg gcccacttgt ttgtgagcaa cataaaatga gaatggttct tggtgtcatt     1980

gttcctggtc gtggatgtgc cattccaaat cgtcctggta tttttgtccg agtagcatat     2040

tatgcaaaat ggatacacaa aattatttta acatataagg taccacagtc atag           2094


<210>  9
<211>  2889
<212>  DNA
<213>  artificial

<220>
<223>  pSNĺ

<400>  9
gcgcagcacc atggcctgaa ataacctctg aaagaggaac ttggttaggt accttctgag       60

gcggaaagaa ccagctgtgg aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc      120

cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg tgtggaaagt      180

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca      240

tagtcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc      300

cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg      360

agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc aaaaagcttg      420

ctagccaccg cggccgcaac ttgtttattg cagcttataa tggttacaaa taaagcaata      480

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca      540

aactcatcaa tgtatcttat catgtctgga tccaggataa tatatggtag ggttcatagc      600

cagagtaacc ttttttttta atttttattt tattttattt tgagctgcag gcatgcaagc      660

tggcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta      720

atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg      780

atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcctgatg cggtattttc      840

tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct      900

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac      960

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     1020

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     1080

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     1140

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     1200

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     1260

tgctggggag tcgaaattca gaagaactcg tcaagaaggc gatagaaggc gatgcgctgc     1320

gaatcgggag cggcgatacc gtaaagcacg aggaagcggt cagcccattc gccgccaagc     1380

tcttcagcaa tatcacgggt agccaacgct atgtcctgat agcggtccgc cacacccagc     1440

cggccacagt cgatgaatcc agaaaagcgg ccattttcca ccatgatatt cggcaagcag     1500

gcatcgccat gggtcacgac gagatcctcg ccgtcgggca tgctcgcctt gagcctggcg     1560

aacagttcgg ctggcgcgag cccctgatgc tcttcgtcca gatcatcctg atcgacaaga     1620

ccggcttcca tccgagtacg tgctcgctcg atgcgatgtt tcgcttggtg gtcgaatggg     1680

caggtagccg gatcaagcgt atgcagccgc cgcattgcat cagccatgat ggatactttc     1740

tcggcaggag caaggtgaga tgacaggaga tcctgccccg gcacttcgcc caatagcagc     1800

cagtcccttc ccgcttcagt gacaacgtcg agcacagctg cgcaaggaac gcccgtcgtg     1860

gccagccacg atagccgcgc tgcctcgtct tgcagttcat tcagggcacc ggacaggtcg     1920

gtcttgacaa aaagaaccgg gcgcccctgc gctgacagcc ggaacacggc ggcatcagag     1980

cagccgattg tctgttgtgc ccagtcatag ccgaatagcc tctccaccca agcggccgga     2040

gaacctgcgt gcaatccatc ttgttcaatc atgcgaaacg atcctcatcc tgtctcttga     2100

tcagatcttg atccctgtca gaccaagttt actcatatat actttagatt gatttaaaac     2160

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa     2220

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     2280

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     2340

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     2400

gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc     2460

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     2520

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     2580

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     2640

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     2700

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     2760

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     2820

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     2880

gcaacgcgg                                                             2889


