                         SEQUENCE LISTING

<110>  Mosaiques Diagnostics und Therapeutics AG
 
<120>  Use of arachidonyl trifluoromethyl ketone

<130>  M 10139 PCT

<150>  EP 19 150 606.2
<151>  2019-01-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  749
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Isoform 1 of cytoplasmic PLA2

<400>  1

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                645                 650                 655     


Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala 
            740                 745                 


<210>  2
<211>  689
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Isoform 2 of cytoplasmic PLA2

<400>  2

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Pro 
        115                 120                 125             


Val Val Ala Ile Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly 
    130                 135                 140                 


Phe Ser Gly Val Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys 
145                 150                 155                 160 


Ala Thr Tyr Val Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr 
                165                 170                 175     


Leu Tyr Ser His Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn 
            180                 185                 190         


Glu Glu Leu Met Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr 
        195                 200                 205             


Pro Gln Lys Val Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser 
    210                 215                 220                 


Ser Gly Gln Pro Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly 
225                 230                 235                 240 


Glu Thr Leu Ile His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys 
                245                 250                 255     


Glu Lys Val Asn Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu 
            260                 265                 270         


His Val Lys Pro Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu 
        275                 280                 285             


Phe Ser Pro Tyr Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala 
    290                 295                 300                 


Pro Asp Leu Phe Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys 
305                 310                 315                 320 


Tyr Glu Glu Asn Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala 
                325                 330                 335     


Phe Ser Ile Leu Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser 
            340                 345                 350         


Arg Gly Ser Thr Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His 
        355                 360                 365             


Ile Val Ser Asn Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro 
    370                 375                 380                 


Lys Gly Thr Glu Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn 
385                 390                 395                 400 


Gln Ala Ser Trp Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser 
                405                 410                 415     


Ala Leu Phe Asn Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe 
            420                 425                 430         


Met Leu Gly Leu Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser 
        435                 440                 445             


Asp Phe Ala Thr Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala 
    450                 455                 460                 


Val Ala Asp Pro Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val 
465                 470                 475                 480 


Lys Ser Lys Lys Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu 
                485                 490                 495     


Pro Tyr Pro Leu Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile 
            500                 505                 510         


Ser Phe Asp Phe Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys 
        515                 520                 525             


Glu Leu Leu Leu Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe 
    530                 535                 540                 


Pro Lys Ile Asp Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys 
545                 550                 555                 560 


Tyr Val Phe Lys Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr 
                565                 570                 575     


Ile Ile His Phe Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala 
            580                 585                 590         


Pro Gly Val Pro Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe 
        595                 600                 605             


Asp Ile Phe Asp Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln 
    610                 615                 620                 


Tyr Pro Asn Gln Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn 
625                 630                 635                 640 


Thr Leu Asn Asn Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile 
                645                 650                 655     


Glu Tyr Arg Arg Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn 
            660                 665                 670         


Val Glu Ala Arg Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys 
        675                 680                 685             


Ala 
    


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Deoxyribonucleotide

<400>  3
uguauugaga uucaagccca g                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Deoxyribonucleotide

<400>  4
gggcuugaau cucaauacat t                                                 21


