                         SEQUENCE LISTING

<110>  Alder Biopharmaceuticals, Inc.
 
<120>  ACUTE TREATMENT AND RAPID TREATMENT OF HEADACHE USING
       ANTI-CGRP ANTIBODIES

<130>  1143257.008601

<160>  567   

<170>  PatentIn version 3.5

<210>  1
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  1

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Ala Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  2
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  2

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Ala Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  3
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  3

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Asp Leu Ser 
            20                  25                  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  4

Ser Tyr Tyr Met Gln 
1               5   


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  5

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  6

Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  7
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  7

Arg Phe Thr Ile Ser Arg Ala Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  8
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  8

Gly Asp Ile 
1           


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  9

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  10
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  11
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggactcga cctcagtagc tactacatgc aatgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt ggtattaatg ataacacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaga gcctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagagggga catctggggc      300

ccaggcaccc tcgtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga     1320


<210>  12
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  12
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggactcga cctcagtagc tactacatgc aatgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt ggtattaatg ataacacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaga gcctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagagggga catctggggc      300

ccaggcaccc tcgtcaccgt ctcgagc                                          327


<210>  13
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  13
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggactcga cctcagt                                           87


<210>  14
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  14
agctactaca tgcaa                                                        15


<210>  15
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  15
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  16
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  16
gtcattggta ttaatgataa cacatactac gcgagctggg cgaaaggc                    48


<210>  17
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  17
cgattcacca tctccagagc ctcgtcgacc acggtggatc tgaaaatgac cagtctgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  18
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  18
ggggacatc                                                                9


<210>  19
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  19
tggggcccag gcaccctcgt caccgtctcg agc                                    33


<210>  20
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  20
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  21
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  21

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  22
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  22

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  23
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  23

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  24
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  24

Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  25

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  26

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  27
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  27

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  28

Leu Gly Ser Tyr Asp Cys Ser Ser Gly Asp Cys Phe Val 
1               5                   10              


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  29

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  30
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  30

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  31
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  31
caagtgctga cccagactgc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagag tgtttatgat aacaactacc tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacatcca ctctggcatc tggggtctca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcta ggcagttatg attgtagtag tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  32
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  32
caagtgctga cccagactgc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagag tgtttatgat aacaactacc tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacatcca ctctggcatc tggggtctca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcta ggcagttatg attgtagtag tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  33
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  33
caagtgctga cccagactgc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgc                                                                  66


<210>  34
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  34
caggccagtc agagtgttta tgataacaac tacctagcc                              39


<210>  35
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  35
tggtatcagc agaaaccagg gcagcctccc aagcaactga tctat                       45


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  36
tctacatcca ctctggcatc t                                                 21


<210>  37
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  37
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  38
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  38
ctaggcagtt atgattgtag tagtggtgat tgttttgtt                              39


<210>  39
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  39
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  40
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  40
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  41
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Asp Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  42
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Asp Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  43
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Asp Leu Ser 
            20                  25                  30  


<210>  44
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  44

Ser Tyr Tyr Met Gln 
1               5   


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  45

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  46
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  46

Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  47
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  47

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  48
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  48

Gly Asp Ile 
1           


<210>  49
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  49

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  51
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  51
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggact cgacctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatca atgataacac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  52
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  52
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggact cgacctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatca atgataacac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  53
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  53
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggact cgacctcagt                                        90


<210>  54
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  54
agctactaca tgcaa                                                        15


<210>  55
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  55
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  56
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  56
gtcattggta tcaatgataa cacatactac gcgagctggg cgaaaggc                    48


<210>  57
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  57
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  58
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  58
ggggacatc                                                                9


<210>  59
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  59
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  60
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  60
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  61
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  61

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  62
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  62

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  63
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  63

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  64
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  64

Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  65
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  65

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  66

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  67
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  67

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  68
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  68

Leu Gly Ser Tyr Asp Cys Ser Ser Gly Asp Cys Phe Val 
1               5                   10              


<210>  69
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  69

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  70
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  70

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  71
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  71
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatgat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtcta ggcagttatg attgtagtag tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  72
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  72
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatgat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtcta ggcagttatg attgtagtag tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  73
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  73
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  74
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  74
caggccagtc agagtgttta tgataacaac tacctagcc                              39


<210>  75
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  75
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  76
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  76
tctacatcca ctctggcatc t                                                 21


<210>  77
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  77
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  78
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  78
ctaggcagtt atgattgtag tagtggtgat tgttttgtt                              39


<210>  79
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  79
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  80
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  80
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  81
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Asp Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  82
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Asp Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  83
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Asp Leu Ser 
            20                  25                  30  


<210>  84
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  84

Ser Tyr Tyr Met Gln 
1               5   


<210>  85
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  85

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  86
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  86

Val Ile Gly Ile Asn Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  87
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  87

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  88
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  88

Gly Asp Ile 
1           


<210>  89
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  89

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  90

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  91
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  91
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggact cgacctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatca atgataacac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  92
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  92
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggact cgacctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatca atgataacac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  93
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  93
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggact cgacctcagt                                        90


<210>  94
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  94
agctactaca tgcaa                                                        15


<210>  95
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  95
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  96
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  96
gtcattggta tcaatgataa cacatactac gcgagctggg cgaaaggc                    48


<210>  97
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  97
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  98
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  98
ggggacatc                                                                9


<210>  99
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  99
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  100
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  100
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  101
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  101

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  102
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  102

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  103
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  103

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  104
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  104

Gln Ala Ser Gln Ser Val Tyr Asp Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  105
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  105

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  106
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  106

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  107
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  107

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  108
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  108

Leu Gly Ser Tyr Asp Cys Ser Ser Gly Asp Cys Phe Val 
1               5                   10              


<210>  109
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  109

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  110
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  110

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  111
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  111
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatgat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtcta ggcagttatg attgtagtag tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  112
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  112
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatgat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtcta ggcagttatg attgtagtag tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  113
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  113
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  114
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  114
caggccagtc agagtgttta tgataacaac tacctagcc                              39


<210>  115
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  115
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  116
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  116
tctacatcca ctctggcatc t                                                 21


<210>  117
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  117
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  118
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  118
ctaggcagtt atgattgtag tagtggtgat tgttttgtt                              39


<210>  119
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  119
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  120
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  120
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  121
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  121

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Ser Val Ser Gly Ile Asp Leu Ser Gly Tyr Tyr 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  122
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  122

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Ser Val Ser Gly Ile Asp Leu Ser Gly Tyr Tyr 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  123
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  123

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Ser Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  124
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  124

Gly Tyr Tyr Met Asn 
1               5   


<210>  125
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  125

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  126
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  126

Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  127
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  127

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  128
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  128

Gly Asp Ile 
1           


<210>  129
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  129

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  130
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  131
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  131
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgttccgtct ctggcatcga cctcagtggc tactacatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt ggtattaatg gtgccacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagagggga catctggggc      300

ccgggcaccc tcgtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga     1320


<210>  132
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  132
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgttccgtct ctggcatcga cctcagtggc tactacatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt ggtattaatg gtgccacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagagggga catctggggc      300

ccgggcaccc tcgtcaccgt ctcgagc                                          327


<210>  133
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  133
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgttccgtct ctggcatcga cctcagt                                           87


<210>  134
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  134
ggctactaca tgaac                                                        15


<210>  135
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  135
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  136
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  136
gtcattggta ttaatggtgc cacatactac gcgagctggg cgaaaggc                    48


<210>  137
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  137
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtctgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  138
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  138
ggggacatc                                                                9


<210>  139
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  139
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  140
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  140
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  141
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  141

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asn Asp Ala Ala Ala Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  142
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  142

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asn Asp Ala Ala Ala Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  143
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  143

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  144
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  144

Gln Ala Ser Gln Ser Val Tyr His Asn Thr Tyr Leu Ala 
1               5                   10              


<210>  145
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  145

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  146
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  146

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  147
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  147

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asn Asp Ala Ala Ala Tyr Tyr Cys 
            20                  25                  30          


<210>  148
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  148

Leu Gly Ser Tyr Asp Cys Thr Asn Gly Asp Cys Phe Val 
1               5                   10              


<210>  149
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  149

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  150
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  150

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  151
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  151
caagtgctga cccagactcc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagag tgtttatcat aacacctacc tggcctggta tcagcagaaa      120

ccagggcagc ctcccaaaca actgatctat gatgcatcca ctctggcgtc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag      240

tgtaacgatg ctgccgctta ctactgtctg ggcagttatg attgtactaa tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  152
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  152
caagtgctga cccagactcc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagag tgtttatcat aacacctacc tggcctggta tcagcagaaa      120

ccagggcagc ctcccaaaca actgatctat gatgcatcca ctctggcgtc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag      240

tgtaacgatg ctgccgctta ctactgtctg ggcagttatg attgtactaa tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  153
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  153
caagtgctga cccagactcc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgc                                                                  66


<210>  154
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  154
caggccagtc agagtgttta tcataacacc tacctggcc                              39


<210>  155
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  155
tggtatcagc agaaaccagg gcagcctccc aaacaactga tctat                       45


<210>  156
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  156
gatgcatcca ctctggcgtc t                                                 21


<210>  157
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  157
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtgcagt gtaacgatgc tgccgcttac tactgt                                 96


<210>  158
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  158
ctgggcagtt atgattgtac taatggtgat tgttttgtt                              39


<210>  159
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  159
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  160
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  160
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  161
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  162
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  163
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser 
            20                  25                  30  


<210>  164
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  164

Gly Tyr Tyr Met Asn 
1               5   


<210>  165
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  165

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  166
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  166

Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  167
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  167

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  168
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  168

Gly Asp Ile 
1           


<210>  169
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  169

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  170
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  170

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  171
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  171
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt ggctactaca tgaactgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatta atggtgccac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  172
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  172
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt ggctactaca tgaactgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatta atggtgccac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  173
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  173
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt                                        90


<210>  174
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  174
ggctactaca tgaac                                                        15


<210>  175
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  175
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  176
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  176
gtcattggta ttaatggtgc cacatactac gcgagctggg cgaaaggc                    48


<210>  177
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  177
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  178
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  178
ggggacatc                                                                9


<210>  179
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  179
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  180
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  180
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  181
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  181

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  182
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  182

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  183
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  183

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  184
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  184

Gln Ala Ser Gln Ser Val Tyr His Asn Thr Tyr Leu Ala 
1               5                   10              


<210>  185
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  185

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  186
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  186

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  187
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  187

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  188
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  188

Leu Gly Ser Tyr Asp Cys Thr Asn Gly Asp Cys Phe Val 
1               5                   10              


<210>  189
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  189

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  190
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  190

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  191
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  191
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatcat aacacctacc tggcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat gatgcatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtactaa tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  192
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  192
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatcat aacacctacc tggcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat gatgcatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtactaa tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  193
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  193
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  194
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  194
caggccagtc agagtgttta tcataacacc tacctggcc                              39


<210>  195
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  195
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  196
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  196
gatgcatcca ctctggcatc t                                                 21


<210>  197
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  197
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  198
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  198
ctgggcagtt atgattgtac taatggtgat tgttttgtt                              39


<210>  199
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  199
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  200
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  200
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  201
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  202
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  203
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser 
            20                  25                  30  


<210>  204
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  204

Gly Tyr Tyr Met Asn 
1               5   


<210>  205
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  205

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  206
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  206

Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  207
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  207

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  208
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  208

Gly Asp Ile 
1           


<210>  209
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  209

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  210
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  210

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  211
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  211
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt ggctactaca tgaactgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatta atggtgccac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  212
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  212
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt ggctactaca tgaactgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatta atggtgccac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  213
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  213
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt                                        90


<210>  214
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  214
ggctactaca tgaac                                                        15


<210>  215
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  215
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  216
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  216
gtcattggta ttaatggtgc cacatactac gcgagctggg cgaaaggc                    48


<210>  217
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  217
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  218
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  218
ggggacatc                                                                9


<210>  219
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  219
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  220
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  220
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  221
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  221

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  222
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  222

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  223
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  223

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  224
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  224

Gln Ala Ser Gln Ser Val Tyr His Asn Thr Tyr Leu Ala 
1               5                   10              


<210>  225
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  225

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  226
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  226

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  227
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  227

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  228
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  228

Leu Gly Ser Tyr Asp Cys Thr Asn Gly Asp Cys Phe Val 
1               5                   10              


<210>  229
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  229

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  230
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  230

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  231
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  231
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatcat aacacctacc tggcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat gatgcatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtactaa tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  232
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  232
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttatcat aacacctacc tggcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat gatgcatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtactaa tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  233
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  233
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  234
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  234
caggccagtc agagtgttta tcataacacc tacctggcc                              39


<210>  235
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  235
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  236
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  236
gatgcatcca ctctggcatc t                                                 21


<210>  237
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  237
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  238
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  238
ctgggcagtt atgattgtac taatggtgat tgttttgtt                              39


<210>  239
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  239
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  240
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  240
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  241
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  241

Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn His 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Val Gly Ile Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Met Thr Arg Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Gly Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  242
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  242

Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn His 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Val Gly Ile Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Met Thr Arg Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Gly Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  243
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  243

Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  30  


<210>  244
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  244

Asn His Tyr Met Gln 
1               5   


<210>  245
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  245

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  246
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  246

Val Val Gly Ile Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  247
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  247

Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Arg Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  248
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  248

Gly Asp Ile 
1           


<210>  249
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  249

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  250
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  250

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  251
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  251
caggagcagc tgaaggagtc cgggggtcgc ctggtcacgc ctgggacatc cctgacactc       60

acctgcaccg tctctggaat cgacctcagt aaccactaca tgcaatgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggagtc gttggtatta atggtcgcac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agaacctcgt cgaccacggt ggatctgaaa      240

atgaccaggc tgacaaccga ggacacggcc acctatttct gtgccagagg ggacatctgg      300

ggcccaggca ccctggtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacaagag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320

tga                                                                   1323


<210>  252
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  252
caggagcagc tgaaggagtc cgggggtcgc ctggtcacgc ctgggacatc cctgacactc       60

acctgcaccg tctctggaat cgacctcagt aaccactaca tgcaatgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggagtc gttggtatta atggtcgcac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agaacctcgt cgaccacggt ggatctgaaa      240

atgaccaggc tgacaaccga ggacacggcc acctatttct gtgccagagg ggacatctgg      300

ggcccaggca ccctggtcac cgtctcgagc                                       330


<210>  253
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  253
caggagcagc tgaaggagtc cgggggtcgc ctggtcacgc ctgggacatc cctgacactc       60

acctgcaccg tctctggaat cgacctcagt                                        90


<210>  254
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  254
aaccactaca tgcaa                                                        15


<210>  255
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  255
tgggtccgcc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  256
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  256
gtcgttggta ttaatggtcg cacatactac gcgagctggg cgaaaggc                    48


<210>  257
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  257
cgattcacca tctccagaac ctcgtcgacc acggtggatc tgaaaatgac caggctgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  258
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  258
ggggacatc                                                                9


<210>  259
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  259
tggggcccag gcaccctggt caccgtctcg agc                                    33


<210>  260
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  260
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  261
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  261

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Tyr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Thr Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  262
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  262

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Tyr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Thr Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  263
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  263

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  264
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  264

Gln Ala Ser Gln Ser Val Tyr Asn Tyr Asn Tyr Leu Ala 
1               5                   10              


<210>  265
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  265

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  266
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  266

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  267
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  267

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  268
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  268

Leu Gly Ser Tyr Asp Cys Ser Thr Gly Asp Cys Phe Val 
1               5                   10              


<210>  269
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  269

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  270
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  270

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  271
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  271
caagtgctga cccagactgc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagag tgtttataat tacaactacc ttgcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacatcca ctctggcatc tggggtctca      180

tcgcgattca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctgccactta ctactgtcta ggcagttatg actgtagtac tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  272
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  272
caagtgctga cccagactgc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagag tgtttataat tacaactacc ttgcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacatcca ctctggcatc tggggtctca      180

tcgcgattca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctgccactta ctactgtcta ggcagttatg actgtagtac tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  273
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  273
caagtgctga cccagactgc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgc                                                                  66


<210>  274
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  274
caggccagtc agagtgttta taattacaac taccttgcc                              39


<210>  275
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  275
tggtatcagc agaaaccagg gcagcctccc aagcaactga tctat                       45


<210>  276
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  276
tctacatcca ctctggcatc t                                                 21


<210>  277
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  277
ggggtctcat cgcgattcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  278
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  278
ctaggcagtt atgactgtag tactggtgat tgttttgtt                              39


<210>  279
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  279
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  280
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  280
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  281
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  281

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn His 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Val Gly Ile Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  282
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  282

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn His 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Val Gly Ile Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  283
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  283

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser 
            20                  25                  30  


<210>  284
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  284

Asn His Tyr Met Gln 
1               5   


<210>  285
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  285

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  286
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  286

Val Val Gly Ile Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  287
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  287

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  288
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  288

Gly Asp Ile 
1           


<210>  289
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  289

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  290
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  290

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  291
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  291
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt aaccactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc gttggtatca atggtcgcac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  292
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  292
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt aaccactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc gttggtatca atggtcgcac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  293
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  293
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt                                        90


<210>  294
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  294
aaccactaca tgcaa                                                        15


<210>  295
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  295
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  296
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  296
gtcgttggta tcaatggtcg cacatactac gcgagctggg cgaaaggc                    48


<210>  297
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  297
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  298
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  298
ggggacatc                                                                9


<210>  299
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  299
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  300
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  300
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  301
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  301

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Tyr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Thr Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  302
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  302

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Tyr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Thr Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  303
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  303

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  304
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  304

Gln Ala Ser Gln Ser Val Tyr Asn Tyr Asn Tyr Leu Ala 
1               5                   10              


<210>  305
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  305

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  306
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  306

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  307
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  307

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  308
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  308

Leu Gly Ser Tyr Asp Cys Ser Thr Gly Asp Cys Phe Val 
1               5                   10              


<210>  309
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  309

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  310
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  310

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  311
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  311
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttacaat tacaactacc ttgcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtac tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  312
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  312
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagag tgtttacaat tacaactacc ttgcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtac tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  313
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  313
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  314
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  314
caggccagtc agagtgttta caattacaac taccttgcc                              39


<210>  315
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  315
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  316
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  316
tctacatcca ctctggcatc t                                                 21


<210>  317
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  317
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  318
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  318
ctgggcagtt atgattgtag tactggtgat tgttttgtt                              39


<210>  319
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  319
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  320
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  320
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  321
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  321

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Gly Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Gln Trp Val Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Arg Met 
65                  70                  75                  80  


Ala Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  322
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  322

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Gly Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Gln Trp Val Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Arg Met 
65                  70                  75                  80  


Ala Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  323
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  323

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Gly Leu Ser 
            20                  25                  


<210>  324
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  324

Ser Tyr Tyr Met Gln 
1               5   


<210>  325
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  325

Trp Val Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  326
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  326

Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  327
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  327

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Arg Met 
1               5                   10                  15      


Ala Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg 
            20                  25                  30      


<210>  328
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  328

Gly Asp Ile 
1           


<210>  329
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  329

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  330
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  330

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  331
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  331
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcgg cctcagtagc tactacatgc agtgggtccg ccagtctcca      120

gggagggggc tggaatggat cggagtcatt ggtagtgatg gtaagacata ctacgcgacc      180

tgggcgaaag gccgattcac catctccaag acctcgtcga ccacggtgga tctgagaatg      240

gccagtctga caaccgagga cacggccacc tatttctgta ccagagggga catctggggc      300

ccggggaccc tcgtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga     1320


<210>  332
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  332
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcgg cctcagtagc tactacatgc agtgggtccg ccagtctcca      120

gggagggggc tggaatggat cggagtcatt ggtagtgatg gtaagacata ctacgcgacc      180

tgggcgaaag gccgattcac catctccaag acctcgtcga ccacggtgga tctgagaatg      240

gccagtctga caaccgagga cacggccacc tatttctgta ccagagggga catctggggc      300

ccggggaccc tcgtcaccgt ctcgagc                                          327


<210>  333
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  333
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcgg cctcagt                                           87


<210>  334
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  334
agctactaca tgcag                                                        15


<210>  335
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  335
tgggtccgcc agtctccagg gagggggctg gaatggatcg ga                          42


<210>  336
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  336
gtcattggta gtgatggtaa gacatactac gcgacctggg cgaaaggc                    48


<210>  337
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  337
cgattcacca tctccaagac ctcgtcgacc acggtggatc tgagaatggc cagtctgaca       60

accgaggaca cggccaccta tttctgtacc aga                                    93


<210>  338
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  338
ggggacatc                                                                9


<210>  339
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  339
tggggcccgg ggaccctcgt caccgtctcg agc                                    33


<210>  340
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  340
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  341
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  341

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Arg 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Arg Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  342
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  342

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Arg 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Arg Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  343
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  343

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  344
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  344

Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  345
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  345

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  346
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  346

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  347
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  347

Gly Val Ser Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  348
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  348

Leu Gly Ser Tyr Asp Cys Ser Arg Gly Asp Cys Phe Val 
1               5                   10              


<210>  349
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  349

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  350
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  350

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  351
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  351
caagtgctga cccagactcc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagaa tgtttataat aacaactacc tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacgtcca ctctggcatc tggggtctca      180

tcgcgattca gaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctgccactta ctactgtcta ggcagttatg attgtagtcg tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  352
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  352
caagtgctga cccagactcc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgccagg ccagtcagaa tgtttataat aacaactacc tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacgtcca ctctggcatc tggggtctca      180

tcgcgattca gaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctgccactta ctactgtcta ggcagttatg attgtagtcg tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  353
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  353
caagtgctga cccagactcc atcccccgtg tctgcagctg tgggaagcac agtcaccatc       60

aattgc                                                                  66


<210>  354
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  354
caggccagtc agaatgttta taataacaac tacctagcc                              39


<210>  355
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  355
tggtatcagc agaaaccagg gcagcctccc aagcaactga tctat                       45


<210>  356
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  356
tctacgtcca ctctggcatc t                                                 21


<210>  357
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  357
ggggtctcat cgcgattcag aggcagtgga tctgggacac agttcactct caccatcagc       60

gacgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  358
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  358
ctaggcagtt atgattgtag tcgtggtgat tgttttgtt                              39


<210>  359
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  359
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  360
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  360
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  361
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  361

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  362
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  362

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  363
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  363

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Leu Ser 
            20                  25                  30  


<210>  364
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  364

Ser Tyr Tyr Met Gln 
1               5   


<210>  365
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  365

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  366
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  366

Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  367
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  367

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr Arg 
            20                  25                  30          


<210>  368
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  368

Gly Asp Ile 
1           


<210>  369
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  369

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  370
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  370

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  371
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  371
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cggcctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtagtg atggtaagac atactacgcg      180

acctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtaccag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  372
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  372
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cggcctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtagtg atggtaagac atactacgcg      180

acctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtaccag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  373
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  373
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cggcctcagt                                        90


<210>  374
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  374
agctactaca tgcaa                                                        15


<210>  375
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  375
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  376
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  376
gtcattggta gtgatggtaa gacatactac gcgacctggg cgaaaggc                    48


<210>  377
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  377
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt accaga                                 96


<210>  378
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  378
ggggacatc                                                                9


<210>  379
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  379
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  380
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  380
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  381
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  381

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Arg Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  382
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  382

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Arg Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  383
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  383

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  384
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  384

Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  385
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  385

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  386
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  386

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  387
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  387

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  388
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  388

Leu Gly Ser Tyr Asp Cys Ser Arg Gly Asp Cys Phe Val 
1               5                   10              


<210>  389
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  389

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  390
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  390

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  391
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  391
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagaa tgtttacaat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtcg tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  392
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  392
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagaa tgtttacaat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtcg tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  393
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  393
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  394
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  394
caggccagtc agaatgttta caataacaac tacctagcc                              39


<210>  395
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  395
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  396
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  396
tctacatcca ctctggcatc t                                                 21


<210>  397
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  397
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  398
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  398
ctgggcagtt atgattgtag tcgtggtgat tgttttgtt                              39


<210>  399
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  399
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  400
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  400
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  401
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  401

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Val Thr Asn Tyr Tyr 
            20                  25                  30          


Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Val Asn Gly Lys Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  402
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  402

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Val Thr Asn Tyr Tyr 
            20                  25                  30          


Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Val Asn Gly Lys Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  403
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  403

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Val Thr 
            20                  25                  


<210>  404
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  404

Asn Tyr Tyr Met Gln 
1               5   


<210>  405
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  405

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  406
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  406

Val Ile Gly Val Asn Gly Lys Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  407
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  407

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  408
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  408

Gly Asp Ile 
1           


<210>  409
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  409

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  410
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  410

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  411
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  411
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg gaggatccct gacactcacc       60

tgcacagtct ctggaatcga cgtcactaac tactatatgc aatgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt ggtgtgaatg gtaagagata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagaggcga catctggggc      300

ccggggaccc tcgtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga     1320


<210>  412
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  412
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg gaggatccct gacactcacc       60

tgcacagtct ctggaatcga cgtcactaac tactatatgc aatgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt ggtgtgaatg gtaagagata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagaggcga catctggggc      300

ccggggaccc tcgtcaccgt ctcgagc                                          327


<210>  413
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  413
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg gaggatccct gacactcacc       60

tgcacagtct ctggaatcga cgtcact                                           87


<210>  414
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  414
aactactata tgcaa                                                        15


<210>  415
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  415
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  416
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  416
gtcattggtg tgaatggtaa gagatactac gcgagctggg cgaaaggc                    48


<210>  417
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  417
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtctgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  418
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  418
ggcgacatc                                                                9


<210>  419
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  419
tggggcccgg ggaccctcgt caccgtctcg agc                                    33


<210>  420
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  421
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  421

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Pro Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Tyr Tyr Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  422
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  422

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Pro Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Tyr Tyr Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  423
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  423

Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Pro Ala Val Gly Ser 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  424
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  424

Arg Ala Ser Gln Ser Val Tyr Tyr Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  425
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  425

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  426
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  426

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  427
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  427

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  428
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  428

Leu Gly Ser Tyr Asp Cys Ser Asn Gly Asp Cys Phe Val 
1               5                   10              


<210>  429
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  429

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  430
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  430

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  431
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  431
caggtgctga cccagactgc atcccccgtg tctccagctg tgggaagcac agtcaccatc       60

aattgccggg ccagtcagag tgtttattat aacaactacc tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacatcca ctctggcatc tggggtctca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctgccactta ctactgtcta ggcagttatg attgtagtaa tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  432
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  432
caggtgctga cccagactgc atcccccgtg tctccagctg tgggaagcac agtcaccatc       60

aattgccggg ccagtcagag tgtttattat aacaactacc tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat tctacatcca ctctggcatc tggggtctca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctgccactta ctactgtcta ggcagttatg attgtagtaa tggtgattgt      300

tttgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  433
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  433
caggtgctga cccagactgc atcccccgtg tctccagctg tgggaagcac agtcaccatc       60

aattgc                                                                  66


<210>  434
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  434
cgggccagtc agagtgttta ttataacaac tacctagcc                              39


<210>  435
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  435
tggtatcagc agaaaccagg gcagcctccc aagcaactga tctat                       45


<210>  436
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  436
tctacatcca ctctggcatc t                                                 21


<210>  437
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  437
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  438
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  438
ctaggcagtt atgattgtag taatggtgat tgttttgtt                              39


<210>  439
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  439
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  440
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  440
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  441
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  441

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Val Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Val Asn Gly Lys Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  442
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  442

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Val Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Val Asn Gly Lys Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  443
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  443

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Val Thr 
            20                  25                  30  


<210>  444
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  444

Asn Tyr Tyr Met Gln 
1               5   


<210>  445
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  445

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  446
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  446

Val Ile Gly Val Asn Gly Lys Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  447
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  447

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  448
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  448

Gly Asp Ile 
1           


<210>  449
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  449

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  450
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  450

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  451
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  451
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacgtcact aactactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtgtga atggtaagag atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgccag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  452
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  452
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacgtcact aactactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtgtga atggtaagag atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgccag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  453
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  453
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacgtcact                                        90


<210>  454
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  454
aactactaca tgcaa                                                        15


<210>  455
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  455
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  456
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  456
gtcattggtg tgaatggtaa gagatactac gcgagctggg cgaaaggc                    48


<210>  457
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  457
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gccaga                                 96


<210>  458
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  458
ggggacatc                                                                9


<210>  459
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  459
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  460
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  460
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  461
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  461

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Tyr Tyr Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  462
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  462

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Tyr Tyr Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  463
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  463

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  464
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  464

Arg Ala Ser Gln Ser Val Tyr Tyr Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  465
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  465

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  466

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  467
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  467

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  468
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  468

Leu Gly Ser Tyr Asp Cys Ser Asn Gly Asp Cys Phe Val 
1               5                   10              


<210>  469
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  469

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  470
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  470

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  471
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  471
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccggg ccagtcagag tgtttactat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtaa tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  472
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  472
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccggg ccagtcagag tgtttactat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtaa tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  473
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  473
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  474
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  474
cgggccagtc agagtgttta ctataacaac tacctagcc                              39


<210>  475
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  475
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  476
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  476
tctacatcca ctctggcatc t                                                 21


<210>  477
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  477
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  478
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  478
ctgggcagtt atgattgtag taatggtgat tgttttgtt                              39


<210>  479
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  479
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  480
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  480
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  481
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  481

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn Ala 
            20                  25                  30          


Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Cys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln 
65                  70                  75                  80  


Leu Asn Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Leu Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  482
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  482

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn Ala 
            20                  25                  30          


Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Cys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln 
65                  70                  75                  80  


Leu Asn Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Leu Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  483
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  483

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  


<210>  484
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  484

Ser Asn Ala Met Trp 
1               5   


<210>  485
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  485

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  486
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  486

Cys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  487
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  487

Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Leu 
1               5                   10                  15      


Asn Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30      


<210>  488
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  488

Asp Leu Asp Leu 
1               


<210>  489
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  489

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  490
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  490

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  491
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  491
cagtcggtgg aggagtccgg gggaggcctg gtccagcctg agggatccct gacactcacc       60

tgcacagcct ctggattcga cttcagtagc aatgcaatgt ggtgggtccg ccaggctcca      120

gggaaggggc tggagtggat cggatgcatt tacaatggtg atggcagcac atactacgcg      180

agctgggtga atggccgatt ctccatctcc aaaacctcgt cgaccacggt gactctgcaa      240

ctgaatagtc tgacagtcgc ggacacggcc acgtattatt gtgcgagaga tcttgacttg      300

tggggcccgg gcaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  492
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  492
cagtcggtgg aggagtccgg gggaggcctg gtccagcctg agggatccct gacactcacc       60

tgcacagcct ctggattcga cttcagtagc aatgcaatgt ggtgggtccg ccaggctcca      120

gggaaggggc tggagtggat cggatgcatt tacaatggtg atggcagcac atactacgcg      180

agctgggtga atggccgatt ctccatctcc aaaacctcgt cgaccacggt gactctgcaa      240

ctgaatagtc tgacagtcgc ggacacggcc acgtattatt gtgcgagaga tcttgacttg      300

tggggcccgg gcaccctcgt caccgtctcg agc                                   333


<210>  493
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  493
cagtcggtgg aggagtccgg gggaggcctg gtccagcctg agggatccct gacactcacc       60

tgcacagcct ctggattcga cttcagt                                           87


<210>  494
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  494
agcaatgcaa tgtgg                                                        15


<210>  495
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  495
tgggtccgcc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  496
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  496
tgcatttaca atggtgatgg cagcacatac tacgcgagct gggtgaatgg c                51


<210>  497
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  497
cgattctcca tctccaaaac ctcgtcgacc acggtgactc tgcaactgaa tagtctgaca       60

gtcgcggaca cggccacgta ttattgtgcg aga                                    93


<210>  498
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  498
gatcttgact tg                                                           12


<210>  499
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  499
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  500
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  500
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  501
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  501

Ala Ile Val Met Thr Gln Thr Pro Ser Ser Lys Ser Val Pro Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Leu Tyr Asn Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Gly Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gly Gly Tyr Arg Ser Asp 
                85                  90                  95      


Ser Val Asp Gly Val Ala Phe Ala Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  502
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  502

Ala Ile Val Met Thr Gln Thr Pro Ser Ser Lys Ser Val Pro Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Leu Tyr Asn Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Gly Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gly Gly Tyr Arg Ser Asp 
                85                  90                  95      


Ser Val Asp Gly Val Ala Phe Ala Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  503
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  503

Ala Ile Val Met Thr Gln Thr Pro Ser Ser Lys Ser Val Pro Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Asn Cys 
            20              


<210>  504
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  504

Gln Ala Ser Glu Ser Leu Tyr Asn Asn Asn Ala Leu Ala 
1               5                   10              


<210>  505
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  505

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  506
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  506

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  507
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  507

Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  508
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  508

Gly Gly Tyr Arg Ser Asp Ser Val Asp Gly Val Ala 
1               5                   10          


<210>  509
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  509

Phe Ala Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  510
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  510

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  511
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  511
gccatcgtga tgacccagac tccatcttcc aagtctgtcc ctgtgggaga cacagtcacc       60

atcaattgcc aggccagtga gagtctttat aataacaacg ccttggcctg gtttcagcag      120

aaaccagggc agcctcccaa gcgcctgatc tatgatgcat ccaaactggc atctggggtc      180

ccatcgcggt tcagtggcgg tgggtctggg acacagttca ctctcaccat cagtggcgtg      240

cagtgtgacg atgctgccac ttactactgt ggaggctaca gaagtgatag tgttgatggt      300

gttgctttcg ccggagggac cgaggtggtg gtcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  512
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  512
gccatcgtga tgacccagac tccatcttcc aagtctgtcc ctgtgggaga cacagtcacc       60

atcaattgcc aggccagtga gagtctttat aataacaacg ccttggcctg gtttcagcag      120

aaaccagggc agcctcccaa gcgcctgatc tatgatgcat ccaaactggc atctggggtc      180

ccatcgcggt tcagtggcgg tgggtctggg acacagttca ctctcaccat cagtggcgtg      240

cagtgtgacg atgctgccac ttactactgt ggaggctaca gaagtgatag tgttgatggt      300

gttgctttcg ccggagggac cgaggtggtg gtcaaacgt                             339


<210>  513
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  513
gccatcgtga tgacccagac tccatcttcc aagtctgtcc ctgtgggaga cacagtcacc       60

atcaattgc                                                               69


<210>  514
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  514
caggccagtg agagtcttta taataacaac gccttggcc                              39


<210>  515
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  515
tggtttcagc agaaaccagg gcagcctccc aagcgcctga tctat                       45


<210>  516
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  516
gatgcatcca aactggcatc t                                                 21


<210>  517
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  517
ggggtcccat cgcggttcag tggcggtggg tctgggacac agttcactct caccatcagt       60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  518
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  518
ggaggctaca gaagtgatag tgttgatggt gttgct                                 36


<210>  519
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  519
ttcgccggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  520
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  520
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  521
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  521

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  522
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  522

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  523
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  523

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Leu Ser 
            20                  25                  30  


<210>  524
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  524

Ser Tyr Tyr Met Gln 
1               5   


<210>  525
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  525

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  526
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  526

Val Ile Gly Ser Asp Gly Lys Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  527
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  527

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr Arg 
            20                  25                  30          


<210>  528
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  528

Gly Asp Ile 
1           


<210>  529
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  529

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  530
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  530

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  531
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  531
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cggcctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtagtg atggtaagac atactacgcg      180

acctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtaccag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaatga                                                                1326


<210>  532
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  532
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cggcctcagt agctactaca tgcaatgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtagtg atggtaagac atactacgcg      180

acctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtaccag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agc                                   333


<210>  533
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  533
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cggcctcagt                                        90


<210>  534
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  534
agctactaca tgcaa                                                        15


<210>  535
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  535
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  536
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  536
gtcattggta gtgatggtaa gacatactac gcgacctggg cgaaaggc                    48


<210>  537
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  537
cgattcacca tctccagaga caattccaag accacggtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt accaga                                 96


<210>  538
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  538
ggggacatc                                                                9


<210>  539
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  539
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  540
<211>  993
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  540
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  541
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  541

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Arg Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  542
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  542

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Ser 
                85                  90                  95      


Arg Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  543
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  543

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys 
            20          


<210>  544
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  544

Gln Ala Ser Gln Asn Val Tyr Asn Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  545
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  545

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  546
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  546

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  547
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  547

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  548
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  548

Leu Gly Ser Tyr Asp Cys Ser Arg Gly Asp Cys Phe Val 
1               5                   10              


<210>  549
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  549

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  550
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  550

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  551
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  551
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagaa tgtttacaat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtcg tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  552
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  552
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgccagg ccagtcagaa tgtttacaat aacaactacc tagcctggta tcagcagaaa      120

ccagggaaag ttcctaagca actgatctat tctacatcca ctctggcatc tggggtccca      180

tctcgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      240

cctgaagatg ttgcaactta ttactgtctg ggcagttatg attgtagtcg tggtgattgt      300

tttgttttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  553
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  553
caagtgctga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc       60

aattgc                                                                  66


<210>  554
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  554
caggccagtc agaatgttta caataacaac tacctagcc                              39


<210>  555
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  555
tggtatcagc agaaaccagg gaaagttcct aagcaactga tctat                       45


<210>  556
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  556
tctacatcca ctctggcatc t                                                 21


<210>  557
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  557
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agcctgcagc ctgaagatgt tgcaacttat tactgt                                 96


<210>  558
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  558
ctgggcagtt atgattgtag tcgtggtgat tgttttgtt                              39


<210>  559
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  559
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  560
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  560
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  561
<211>  37
<212>  PRT
<213>  Homo sapiens

<220>
<223> C-term amidated

<400>  561

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  562
<211>  37
<212>  PRT
<213>  Homo sapiens

<220>
<223> C-term amidated

<400>  562

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  563
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  563

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  564
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  564

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  565
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  565

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  566
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  566

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440 


<210>  567
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  Engineered antibody sequence

<400>  567
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggaat cgacctcagt ggctactaca tgaactgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggagtc attggtatta atggtgccac atactacgcg      180

agctgggcga aaggccgatt caccatctcc agagacaatt ccaagaccac ggtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag aggggacatc      300

tggggccaag ggaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

tga                                                                   1323


