                         SEQUENCE LISTING

<110>  Omeros Corporation
 
<120>  Methods and Compositions for Treating Cancer

<130>  OG.1.0294.PCT

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp 
1               5                   10                  15      


Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 
            20                  25                  30          


Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 
        35                  40                  45              


Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala 
    50                  55                  60                  


Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 
65                  70                  75                  80  


Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 
                85                  90                  95      


Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 
            100                 105                 110         


Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp 
        115                 120                 125             


Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile 
    130                 135                 140                 


Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp 
145                 150                 155                 160 


Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn 
                165                 170                 175     


Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile 
            180                 185                 190         


Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr 
        195                 200                 205             


Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu 
    210                 215                 220                 


Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu 
225                 230                 235                 240 


Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 
                245                 250                 255     


Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile 
            260                 265                 270         


Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 
        275                 280                 285             


Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser 
    290                 295                 300                 


Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val 
305                 310                 315                 320 


Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys 
                325                 330             


<210>  2
<211>  1258
<212>  DNA
<213>  Homo sapiens

<400>  2
caccattagg caaagatagt ttctctagag agaatcatgc ctgctaatta cacgtgtacc       60

aggccagatg gagacaatac agattttcga tactttattt atgcagtgac atacactgtc      120

attcttgtgc caggtctcat agggaatata ttagccctgt gggtattcta tggttatatg      180

aaagaaacaa aacgagctgt gatatttatg ataaacttag ccattgctga cttactacaa      240

gttctttcct tgccactgag gatcttctac tacttgaatc atgactggcc atttgggcct      300

ggtctctgca tgttctgttt ctacctgaag tatgtcaaca tgtatgcaag catctacttc      360

ttggtctgca tcagtgtgcg acgattttgg tttctcatgt acccctttcg cttccatgac      420

tgcaaacaga aatatgacct gtacatcagc attgctggct ggctgatcat ctgccttgcc      480

tgtgtactct ttccactcct cagaaccagt gatgatacct ctggcaatag gaccaaatgc      540

tttgtggatc ttcctaccag gaatgtcaac ctggcccagt ccgttgttat gatgaccatt      600

ggcgagttga ttgggtttgt aactccgctt ctgattgtcc tatattgtac ctggaagacg      660

gttttatcac tgcaagataa atatcccatg gcccaagatc ttggagagaa acagaaagcc      720

ttgaagatga ttctaacctg tgcaggggta ttcctaattt gctttgcacc ttatcatttc      780

agttttcctt tagatttcct ggtgaagtcc aatgaaatta aaagctgcct agccagaagg      840

gtgattctaa tatttcattc tgtggcattg tgtcttgcta gtctgaattc atgtcttgac      900

ccagtcatat actacttttc cactaatgag ttccgaagac ggctttcaag acaagatttg      960

catgacagca tccaactcca tgcaaaatcc tttgtgagta accatacagc ttccaccatg     1020

acacctgaat tatgctaaaa caaaaaacca aactgaatgt gacctgaaat gcaagtacat     1080

cagaacatat ctgcaatacc caagccacag ggaagaactt gcaaaacaac acagcttttc     1140

agttctgctc tatcttactg ctatggggaa ttcacttctt caaagcagga cctatttgga     1200

gcattacgat ccacgattat tgatgttgac atgtccatgt agtaattttt cttcaagt       1258


<210>  3
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  3

Met Thr Asp Asn Phe Thr Cys Asn Lys Thr Asp Gly Asp Asn Thr Asp 
1               5                   10                  15      


Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 
            20                  25                  30          


Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 
        35                  40                  45              


Lys Glu Thr Lys Arg Ala Val Val Phe Met Ile Asn Leu Ala Ile Ala 
    50                  55                  60                  


Asp Leu Leu Gln Ile Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 
65                  70                  75                  80  


Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 
                85                  90                  95      


Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 
            100                 105                 110         


Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe Asn Asp 
        115                 120                 125             


Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ile Gly Trp Leu Ile 
    130                 135                 140                 


Ile Cys Leu Ala Cys Leu Leu Phe Pro Leu Leu Arg Thr Asn Asp Asp 
145                 150                 155                 160 


Thr Pro Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Ile Arg Asn 
                165                 170                 175     


Val Asn Leu Ala Gln Ser Val Ala Met Ile Thr Ile Gly Glu Val Val 
            180                 185                 190         


Gly Phe Val Thr Pro Leu Met Ile Val Leu Tyr Cys Thr Trp Lys Thr 
        195                 200                 205             


Ala Leu Ser Leu Gln Asn Lys Tyr Pro Ile Ser Gln His Leu Gly Glu 
    210                 215                 220                 


Lys Lys Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu 
225                 230                 235                 240 


Val Cys Phe Val Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 
                245                 250                 255     


Lys Ser Asn Glu Ile Lys Ser Cys Phe Ala Arg Arg Val Ile Leu Ile 
            260                 265                 270         


Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 
        275                 280                 285             


Pro Val Ile Tyr Tyr Phe Thr Thr Asn Glu Phe Arg Arg Arg Leu Ser 
    290                 295                 300                 


Arg Gln Asp Leu Pro Asp Asn Ile Gln Leu His Thr Lys Ser Tyr Lys 
305                 310                 315                 320 


Ile Ala Ser Asn His Ala Thr Ser Thr Val Ala Ala Glu Leu Cys 
                325                 330                 335 


<210>  4
<211>  335
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Thr Asp Asn Phe Thr Cys Asn Lys Thr Asp Gly Asp Asn Thr Asp 
1               5                   10                  15      


Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 
            20                  25                  30          


Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 
        35                  40                  45              


Lys Glu Thr Lys Arg Ala Val Val Phe Met Ile Asn Leu Ala Ile Ala 
    50                  55                  60                  


Asp Leu Leu Gln Ile Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 
65                  70                  75                  80  


Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 
                85                  90                  95      


Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 
            100                 105                 110         


Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe Asn Asp 
        115                 120                 125             


Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Val Gly Trp Leu Ile 
    130                 135                 140                 


Ile Cys Leu Ala Cys Leu Leu Phe Pro Leu Leu Arg Thr Asn Asp Asp 
145                 150                 155                 160 


Thr Pro Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Ile Arg Asn 
                165                 170                 175     


Val Asn Leu Ala Gln Ser Val Ala Met Ile Thr Ile Gly Glu Val Val 
            180                 185                 190         


Gly Phe Ile Thr Pro Leu Met Ile Val Leu Tyr Cys Thr Trp Lys Thr 
        195                 200                 205             


Ala Leu Ser Leu Gln Asn Lys Tyr Pro Ile Ser Gln His Leu Gly Glu 
    210                 215                 220                 


Lys Lys Lys Ala Leu Arg Met Ile Leu Thr Cys Ala Ala Val Phe Leu 
225                 230                 235                 240 


Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 
                245                 250                 255     


Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile 
            260                 265                 270         


Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 
        275                 280                 285             


Pro Val Ile Tyr Tyr Phe Thr Thr Asn Glu Phe Arg Arg Arg Leu Ser 
    290                 295                 300                 


Arg Gln Glu Leu Pro Asp Ser Ile Gln Leu Gln Thr Lys Ser Tyr Lys 
305                 310                 315                 320 


Ile Val Asn Asn His Gly Ala Ser Pro Thr Ala Ala Glu Leu Cys 
                325                 330                 335 


<210>  5
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Ala Ser Asn Glu Asn Met Glu Thr Met 
1               5                   


