                         SEQUENCE LISTING

<110>  Breitenbronn-Consulting GbR
 
<120>  Composition for administering and releasing oligonucleotides

<130>  B 3847WO

<150>  EP 19 153 663.0
<151>  2019-01-25

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gapmer oliguncleotide with a central single stranded DNA 
       oligonucleotide sequence flanked on both ends by single stranded 
       2'-O-methyl RNA oligonucleotide sequences and having 
       phosphorothioate-modified internucleotide phosphates


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-methyladenosine, um, 2'-O-methyl-5-methylcytidine, 
       2'-O-methyladenosine

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate-modified internucleotide phosphates

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-5-methylcytidine

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-5-methylcytidine, 2'-deoxy-5-methylcytidine

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  2'-O-methyladenosine, gm, um, gm

<400>  1
ancagatgcg tggcctannn                                                   20


